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CN110139667A - 一种使胰高血糖素、胰岛素恢复正常平衡的方法 - Google Patents

一种使胰高血糖素、胰岛素恢复正常平衡的方法 Download PDF

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Publication number
CN110139667A
CN110139667A CN201780078124.3A CN201780078124A CN110139667A CN 110139667 A CN110139667 A CN 110139667A CN 201780078124 A CN201780078124 A CN 201780078124A CN 110139667 A CN110139667 A CN 110139667A
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Prior art keywords
plasminogen
group
insulin
expression
subject
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李季男
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Talengen Institute of Life Sciences Co Ltd
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Talengen Institute of Life Sciences Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

本发明涉及一种使胰高血糖素、胰岛素恢复正常平衡的方法，包括给药受试者有效量的纤溶酶原，同时本发明涉及用于使胰高血糖素、胰岛素恢复正常平衡的药物。

Description

PCT国内申请，说明书已公开。

Claims (48)

  1. PCT国内申请，权利要求书已公开。
CN201780078124.3A 2016-12-15 2017-06-19 一种使胰高血糖素、胰岛素恢复正常平衡的方法 Pending CN110139667A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/110171 2016-12-15
CNPCT/CN2016/110171 2016-12-15
PCT/CN2017/089066 WO2018107706A1 (zh) 2016-12-15 2017-06-19 一种使胰高血糖素、胰岛素恢复正常平衡的方法

Publications (1)

Publication Number Publication Date
CN110139667A true CN110139667A (zh) 2019-08-16

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
CN201780078124.3A Pending CN110139667A (zh) 2016-12-15 2017-06-19 一种使胰高血糖素、胰岛素恢复正常平衡的方法
CN201780078168.6A Pending CN110198732A (zh) 2016-12-15 2017-06-19 一种促进胰岛素受体底物-2表达的方法
CN201780078122.4A Pending CN110366426A (zh) 2016-12-15 2017-06-19 一种促进胰岛素分泌的方法
CN201780078131.3A Pending CN110121357A (zh) 2016-12-15 2017-06-19 一种治疗糖尿病的新方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN201780078168.6A Pending CN110198732A (zh) 2016-12-15 2017-06-19 一种促进胰岛素受体底物-2表达的方法
CN201780078122.4A Pending CN110366426A (zh) 2016-12-15 2017-06-19 一种促进胰岛素分泌的方法
CN201780078131.3A Pending CN110121357A (zh) 2016-12-15 2017-06-19 一种治疗糖尿病的新方法

Country Status (9)

Country Link
US (4) US20190314464A1 (zh)
EP (4) EP3556390B1 (zh)
JP (6) JP7554557B2 (zh)
CN (4) CN110139667A (zh)
CA (4) CA3047176C (zh)
DK (1) DK3556383T5 (zh)
ES (1) ES2981141T3 (zh)
TW (7) TW201822803A (zh)
WO (7) WO2018107701A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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JP2019500426A (ja) 2015-12-18 2019-01-10 タレンゲン インターナショナル リミティッドＴａｌｅｎｇｅｎ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ 糖尿病網膜症を予防または治療するための方法
ES2982294T3 (es) 2015-12-18 2024-10-15 Talengen Int Ltd Plasminógeno para su uso en el tratamiento o prevención de lesiones nerviosas por diabetes mellitus
CN108778307A (zh) 2015-12-18 2018-11-09 泰伦基国际有限公司 一种预防和治疗糖尿病肾病的方法
DK3391902T5 (da) 2015-12-18 2024-09-23 Talengen Int Ltd Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati
WO2018107694A1 (zh) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种预防和治疗皮肤纤维化的方法
CN110139667A (zh) * 2016-12-15 2019-08-16 泰伦基国际有限公司 一种使胰高血糖素、胰岛素恢复正常平衡的方法
US11938172B2 (en) 2017-06-19 2024-03-26 Talengen International Limited Method for regulating and controlling GLP-1/GLP-1R and drug
CN111411072B (zh) * 2020-03-09 2022-10-11 同济大学 SLC30A8基因表达下调的抗糖尿病胰岛β细胞及其应用

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JP2020502150A (ja) 2020-01-23
US11311607B2 (en) 2022-04-26
US20190314463A1 (en) 2019-10-17
TW201822801A (zh) 2018-07-01
WO2018107702A1 (zh) 2018-06-21
DK3556383T3 (da) 2024-05-13
CA3047173A1 (en) 2018-06-21
JP2020510628A (ja) 2020-04-09
WO2018107704A1 (zh) 2018-06-21
JP2022166028A (ja) 2022-11-01
TW201822808A (zh) 2018-07-01
EP3556390A1 (en) 2019-10-23
EP3556384B1 (en) 2024-04-10
TW201822802A (zh) 2018-07-01
WO2018107706A1 (zh) 2018-06-21
WO2018107701A1 (zh) 2018-06-21
CN110198732A (zh) 2019-09-03
US20190307861A1 (en) 2019-10-10
EP3556384A1 (en) 2019-10-23
TWI644682B (zh) 2018-12-21
WO2018107703A1 (zh) 2018-06-21
TWI669130B (zh) 2019-08-21
EP3556392A1 (en) 2019-10-23
CA3047176A1 (en) 2018-06-21
TWI763681B (zh) 2022-05-11
JP7175270B2 (ja) 2022-11-18
DK3556383T5 (da) 2024-09-02
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