CN110090219A - A kind of quick treatment is had a toothache with the drug of oral inflammation and preparation method thereof - Google Patents
A kind of quick treatment is had a toothache with the drug of oral inflammation and preparation method thereof Download PDFInfo
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- CN110090219A CN110090219A CN201910376137.XA CN201910376137A CN110090219A CN 110090219 A CN110090219 A CN 110090219A CN 201910376137 A CN201910376137 A CN 201910376137A CN 110090219 A CN110090219 A CN 110090219A
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- drug
- toothache
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- oral inflammation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Life Sciences & Earth Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
The present invention relates to the anti-inflammatory drugs that relieves the pain, have a toothache more particularly to a kind of quickly treatment with the drug of oral inflammation and preparation method thereof, the drug contains the anti-inflammatory component that relieves the pain, penetrating agent and solvent, the penetrating agent is one of benzyl alcohol, acetone, azone, Phenoxyethanol, polypropylene carbonate or a variety of, in proportion crushes each ingredient when preparation and mixes.Present invention realization is quickly non-narcotic to relieve the pain, and relieves pain within 5 to 20 seconds；Realize it is long-acting relieve the pain, relieve the pain duration 4-8 hour；Exterior-applied plant is anti-inflammatory, avoids the drug resistance of oral antibiotic, the side effects such as gastrointestinal reaction.
Description
Technical field
The present invention relates to the anti-inflammatory drugs that relieves the pain, and in particular to one kind quickly treats the drug and its system having a toothache with oral inflammation
Preparation Method.
Background technique
Periodontitis, the oral inflammations such as gingivitis have become the high kinds of Diseases of oral cavity disease incidence, according to national health number
According to display: disease incidence 44.7%.
Have a toothache caused by treatment a variety of causes at present and common are two kinds of methods, first, local use anesthetic such as: benefit
Cacaine, procaine, the anesthetic such as Bupivacaine, but this anesthetic is not due to removing the essential reason having a toothache so can only be temporary
When relieve pain.Second, oral ibuprofen relieves the pain, while cooperating oral antibiotic anti-inflammatory, and disadvantage action generally requires 3-4 slowly very much
A hour.Therefore, only having a toothache safely and fast, green are anti-inflammatory (i.e. using the anti-inflammatory drug resistance for avoiding oral antibiotic of plant react)
It is the thing with great social effect.
The product of anti-drug resistance reaction common at present is based on mouthwash: main component is the antibacterial chlorhexidine of disinfection,
It is anti-inflammatory that essence remains antibiotic, and defect is also to destroy oral cavity inner ring while killing various bacillus and S. aureus L-forms in oral cavity
Border is difficult to accomplish to solve primary pain problem according to its basic principle, specifically include:
1, compound chlorine oneself antivirus bacteriostatic agent or plant extracts antibacterial agent is widely used.
2, internal environment of oral cavity i.e. normal oral pH value is had ignored: between 6.5-7.1, slight slant acidity.
3, do not focus on restoring environment in normal oral, the lysozyme for allowing internal environment of oral cavity reply that can be conducive to saliva of buccal cavity is molten
It solves bacterium and accelerates local inflammation decline.
4, internal environment of oral cavity can be destroyed by, which being used for a long time, causes inflammation to recur.
5, it quick and complete cannot permeate and the satisfied antiphlogistic effects that relieve the pain are not achieved.
Summary of the invention
The purpose of the present invention is overcoming drawbacks described above, one kind is provided and quickly treats the drug and its system having a toothache with oral inflammation
Preparation Method.
Technical solution of the present invention: one kind quickly treating the drug having a toothache with oral inflammation, containing the anti-inflammatory component that relieves the pain, promotees
Penetration enhancer and solvent,
The penetrating agent is one of benzyl alcohol, acetone, azone, Phenoxyethanol, polypropylene carbonate or a variety of.
Menthol and menthones can be relieved the pain with fast cooling physics, and salicylic acid anti-inflammatory can relieve the pain, sialic acid, nerol,
Citral has anti-inflammatory effect.
Further, by weight percentage, solvent 50-99%, the anti-inflammatory component that relieves the pain are 0.004-40%, and penetrating agent is
0.001-5%.
Further, by weight percentage, further include the sialic acid of 0.01-0.3%, 0.01-0.1% lyase,
The potassium sodium calcium salt of 0.01-1% and the neutral thickener of 0.005-1%.
Further, the anti-inflammatory component that relieves the pain is one of salicylic acid, menthol, menthones, nerol, citral
Or it is a variety of；The solvent is one of water, vegetable oil or mineral oil or a variety of.
Further, the pH of the drug is 6.6-6.7.
Further, external application similar drug is made in the drug.
It further, by weight percentage, further include the preservative of 0.001-5%, the preservative is benzoic acid, dehydrogenation
Acetic acid or sorbic acid.
It further, by weight percentage, further include the stabilizer of 0.001-5%, the stabilizer is EDTA or poly- horse
Tired acid anhydrides.
It further, by weight percentage, further include the antioxidant of 0.001-2%, the antioxidant is vitamin C
Or vitamin E.
It further, by weight percentage, further include the edible pigment of 0.001-1%.
Further, by weight percentage, when pulvis is made, the hypertensor of 0.001-70% is added, the hypertensor is
Butane or nitrogen.
The present invention also provides a kind of methods for preparing mentioned-above quick treatment and having a toothache with the drug of oral inflammation, in nothing
Under the dry environment of water, each ingredient is weighed in proportion, and be milled into the powder of D < 0.1mm, be heated to 75 after solvent and water is added
Degree Celsius, it stirs evenly, hybrid package.
The present invention compared with prior art the utility model has the advantages that the present invention realize quickly it is non-narcotic relieve the pain, alleviations in 5 to 20 seconds ache
Bitterly；Realize it is long-acting relieve the pain, relieve the pain duration 4-8 hour；Exterior-applied plant is anti-inflammatory, avoids the drug resistance of oral antibiotic, gastrointestinal tract
The side effects such as reaction.
1, environment in Mouthsimulator, by the adjustment of solvent ratios and concentration make drug pH value control 6.6-6.7 it
Between.
2, the organic principles such as sialic acid, lyase are added.
3, cooperate sodium salt, calcium salt, sylvite inorganic salts.
4, using neutral thickener, such as Acritamer 940 or macromolecular Sodium Hyaluronate, viscosity is controlled as 0.69CP.
5, from inorganic constituents, organic biological active ingredient, viscosity, the ingredient simulation of pH value realization artificial saliva.
6, using mint extract, rose extract, Ilex extract realize orientation it is anti-inflammatory avoid killing it is prebiotic in oral cavity
Bacterium.
7, it allows effective component to infiltrate into diseased region completely by the improvement of bleeding agent and realizes the anti-inflammatory effect of quick pain relief.
Specific embodiment
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention
Rather than it limits the scope of the invention.In addition, it should also be understood that, after reading the content taught by the present invention, those skilled in the art
Member can various modifications may be made or change, such equivalent forms equally fall within the application the appended claims and limited to the present invention
Range.
Embodiment 1:
The present embodiment is made 3 kinds using different ratio and quickly treats the drug having a toothache with oral inflammation, carries out pharmacodynamic test,
It is as follows respectively:
Drug A, proportion are as follows: water 99g, salicylic acid 0.2g, menthol 0.3g, sialic acid 0.01g, sodium salt 0.01g, sylvite
0.01g, calcium salt 0.015g, lyase 0.01g, menthones 0.177g, benzyl alcohol 0.001g, benzoic acid 0.2g, EDTA0.01g,
Vitamin C 0.01g, pigment 0.002g, hypertensor butane 0.04g, neutral thickener (1,200,000 molecular weight Sodium Hyaluronate)
0.005g。
In the environment of dried over anhydrous, weigh each ingredient in proportion, and be milled into the powder of D < 0.1mm, be added solvent and
It is heated to 75 degrees Celsius after water, stirs evenly, pulvis is made in hybrid package, and the spray bottle with respective nozzle is cooperated to use.
Drug B, proportion are as follows: water 76g, vegetable oil 17g, sialic acid 0.1g, sylvite 0.1g, calcium salt 0.2g, sodium salt 0.2g are molten
Enzyme 0.05g, menthones 2.05g, acetone 0.3g are solved, azone 0.2g, dehydroactic acid 1g, EDTA2g, vitamin C 0.5g eat color
Plain 0.2g, neutral thickener (1,200,000 molecular weight Sodium Hyaluronate) 0.1g.
In the environment of dried over anhydrous, weigh each ingredient in proportion, and be milled into the powder of D < 0.1mm, be added solvent and
It is heated to 75 degrees Celsius after water, stirs evenly, spraying aqua is made in hybrid package.
Drug C, proportion are as follows: water 55g, mineral oil 5g, sialic acid 0.3g, sylvite 0.3g, calcium salt 0.4g, sodium salt 0.3g are molten
Solve enzyme 0.1g, menthones 5g, nerol 8g, citral 6.6g, Phenoxyethanol 3g, polypropylene carbonate 2g, sorbic acid 5g, poly- horse
Tired acid anhydrides 5g, vitamin E2 g, edible pigment 1g, neutral thickener (1,200,000 molecular weight Sodium Hyaluronate) 1g.
In the environment of dried over anhydrous, weigh each ingredient in proportion, and be milled into the powder of D < 0.1mm, be added solvent and
It is heated to 75 degrees Celsius after water, stirs evenly, spraying finish is made in hybrid package.
After the completion of above-mentioned 3 parts of medicine preparations, in Pucheng County, the second department of stomatology, Hospital chooses 30 ages had at 10-70 years old
The patient of gingivitis, the common orals such as periodontitis inflammation and pain is randomly divided into 3 groups as test object, every group of 10 people, and three groups
Patient uses drug A, drug B, drug C respectively.After liniment, the treatment condition of 30 patients is recorded, as the result is shown: using
10 people of drug A, averagely pain starts to alleviate after 22 seconds, and drug effect continues 6 hours；Using 10 people of drug B, ache after 13 seconds average
Pain starts to alleviate, and drug effect continues 8 hours；Using 10 people of drug C, averagely pain starts to alleviate after 15 seconds, and it is small that drug effect continues 5
When.
Embodiment 2:
Usually, since the mucous membrane of gingival surface has buffer action, quick pain relief and anti-inflammatory substance are difficult to permeate, go forward side by side
Enter the blood circulation system of human body.The present invention tested nearly hundred kinds of penetrating agents, and having found can help drug ingedient effectively to permeate
Method.And very satisfied effect is obtained in a series of human test.
Test cases citing: 120 ages there is into gingivitis between 10 years old to 70 years old, the common orals such as periodontitis are scorching
The patient of disease and pain is divided into two groups as test object, I group and II group each 60.
Make spraying (1 drug A of example) A and spraying (1 drug B of example) B.
It tests the first round: respectively to I group using spraying A, spraying B being used to II group.Position is sprayed in pain gum part
100mg or so.The results show that there is 9 people to indicate obvious pain relief in 60 testers of I group after 60 seconds.15 people indicate one
It is fixed to improve.36 people indicate no any improvement.There are 49 people to indicate that pain is relieved in 60 testers of II group.10 people indicate
It is certain to improve.1 people indicates no any improvement.
The second wheel of test: two groups of conversation tests after 4 hours use spraying A to II group respectively to I group using spraying B.Spray
Position is spilt in pain gum part 100mg or so.The results show that there is 51 people to indicate pain in 60 testers of I group after 60 seconds
It is relieved.9 people indicate certain improvement.0 people indicates no any improvement.There are 10 people to indicate pain in 60 testers of II group
It is obviously improved.12 people indicate certain improvement.38 people indicate no any improvement.
From test result analysis, the addition of benzyl alcohol, hence it is evident that the function and effect of drug ingedient are improved, so that passing through originally
External application can be absorbed almost without the drug ingedient of effect by skin, play the anti-inflammatory work that significantly relieves the pain to gum portion pain
With.
Embodiment 3:
Comparative test selected for 80 name ages between 10 years old to 70 years old in the second the People's Hospital of Pucheng County department of stomatology
Have a gingivitis, the patient of the common orals such as periodontitis inflammation and pain is divided into 4 groups, every group of 20 people as subjects.To
One group, the drug A prepared using embodiment 1；To second group, the drug B that is prepared using embodiment 1；To third group, implementation is used
Drug C prepared by example 1；To the 4th group, the drug oral brufen (Xi'an Yang Sen) bought on the market is used.
As the result is shown: after 60 seconds, 15 people indicate that pain is relieved in first group of 20 patients, and 4 people indicate certain
Improve, 1 people does not have any improvement.16 people indicate that pain is relieved in second group of 20 patients, and 4 people indicate centainly to change
It is kind.14 people indicate that pain is relieved in 20 patients of third group, and 5 people indicate certain improvement, and 1 people does not have any improvement.
2 people indicate that pain is relieved in 4th group of 20 patients, and 3 people indicate certain improvement, and 15 people do not have any improvement.
From test result analysis, 1, the adjustment of drug pH value；2, by adding saliva physiological ingredient；3, penetrating agent adds
Enter, hence it is evident that the function and effect for improving drug ingedient allow and led to originally by being applied with almost without the drug ingedient of effect
Skin absorption is crossed, the anti-inflammatory effect that significantly relieves the pain is played to gum portion pain.Conclusion is had been found through experimentation that, by formula
Adjustment and improvement drug absorptivity in use and bioavailability is greatly improved.
Claims (10)
1. one kind quickly treats the drug having a toothache with oral inflammation, which is characterized in that contain the anti-inflammatory component that relieves the pain, penetrating agent and molten
Agent,
The penetrating agent is one of benzyl alcohol, acetone, azone, Phenoxyethanol, polypropylene carbonate or a variety of.
2. the drug that quick treatment according to claim 1 is had a toothache with oral inflammation, which is characterized in that percentage by weight
Than solvent 50-99%, the anti-inflammatory component that relieves the pain is 0.004-40%, penetrating agent 0.01-5%.
3. the drug that quick treatment according to claim 1 is had a toothache with oral inflammation, which is characterized in that percentage by weight
Than further including the potassium sodium calcium salt and 0.005-1% of the sialic acid of 0.01-0.3%, the lyase of 0.01-0.1%, 0.01-1%
Neutral thickener.
4. the drug that quick treatment according to claim 1 is had a toothache with oral inflammation, which is characterized in that it is described relieve the pain it is anti-inflammatory
Ingredient is one of salicylic acid, menthol, menthones, nerol, citral or a variety of；The solvent be water, vegetable oil or
One of mineral oil is a variety of.
5. the drug that quick treatment according to claim 1 is had a toothache with oral inflammation, which is characterized in that the pH of the drug
For 6.6-6.7.
6. the drug that quick treatment according to claim 1 is had a toothache with oral inflammation, which is characterized in that the drug is made
It is applied with similar drug.
7. the drug that quick treatment according to claim 1 is had a toothache with oral inflammation, which is characterized in that percentage by weight
Than further including the preservative of 0.001-5%, the preservative is benzoic acid, dehydroactic acid or sorbic acid.
8. the drug that quick treatment according to claim 1 is had a toothache with oral inflammation, which is characterized in that percentage by weight
Than further including the stabilizer of 0.001-5%, the stabilizer is EDTA or poly- Male acid anhydrides.
9. the drug that quick treatment according to claim 1 is had a toothache with oral inflammation, which is characterized in that percentage by weight
Than further including the antioxidant of 0.001-2%, the antioxidant is vitamin C or vitamin E.
10. a kind of method for preparing the described in any item quick treatments of claim 1-9 and having a toothache with the drug of oral inflammation, special
Sign is, in the environment of dried over anhydrous, weighs each ingredient in proportion, and be milled into the powder of D < 0.1mm, and solvent and water is added
After be heated to 75 degrees Celsius, stir evenly, hybrid package.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910376137.XA CN110090219A (en) | 2019-05-07 | 2019-05-07 | A kind of quick treatment is had a toothache with the drug of oral inflammation and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910376137.XA CN110090219A (en) | 2019-05-07 | 2019-05-07 | A kind of quick treatment is had a toothache with the drug of oral inflammation and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116059128A (en) * | 2021-11-01 | 2023-05-05 | 嘉必优生物技术（武汉）股份有限公司 | Anti-inflammatory compositions |
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| CN1500477A (en) * | 2002-11-13 | 2004-06-02 | 丛繁滋 | Quick result aerosol with plant aroma and its preparation |
| CN105267104A (en) * | 2015-11-23 | 2016-01-27 | 云南七丹药业股份有限公司 | Natural herbal toothpaste with function of periodontitis treatment and preparation method of natural herbal toothpaste |
| CN105687186A (en) * | 2015-12-31 | 2016-06-22 | 卢秋妤 | Sleeping medicinal preparation for external use and preparation method thereof |
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2019
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| CN1500477A (en) * | 2002-11-13 | 2004-06-02 | 丛繁滋 | Quick result aerosol with plant aroma and its preparation |
| CN105267104A (en) * | 2015-11-23 | 2016-01-27 | 云南七丹药业股份有限公司 | Natural herbal toothpaste with function of periodontitis treatment and preparation method of natural herbal toothpaste |
| CN105687186A (en) * | 2015-12-31 | 2016-06-22 | 卢秋妤 | Sleeping medicinal preparation for external use and preparation method thereof |
| CN109394903A (en) * | 2018-12-28 | 2019-03-01 | 海南海药本草生物科技有限公司 | A kind of with borneol cinnamomum camphora is the oral care composition of monarch |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116059128A (en) * | 2021-11-01 | 2023-05-05 | 嘉必优生物技术（武汉）股份有限公司 | Anti-inflammatory compositions |
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Application publication date: 20190806 |