CN110025818A - A kind of chitosan piezoelectric membrane and the preparation method and application thereof - Google Patents
A kind of chitosan piezoelectric membrane and the preparation method and application thereof Download PDFInfo
- Publication number
- CN110025818A CN110025818A CN201910181096.9A CN201910181096A CN110025818A CN 110025818 A CN110025818 A CN 110025818A CN 201910181096 A CN201910181096 A CN 201910181096A CN 110025818 A CN110025818 A CN 110025818A
- Authority
- CN
- China
- Prior art keywords
- chitosan
- piezoelectric membrane
- piezoelectric
- preparation
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention provides a kind of preparation method of chitosan piezoelectric membrane, which, which includes the following steps: to dissolve chitosan in, forms chitosan solution in hexafluoroisopropanol, obtains chitosan piezoelectric membrane after solvent volatilization completely.The chitosan piezoelectric membrane has good biocompatibility and tensile property, when being applied to wound repair, accelerates the healing of the surface of a wound.
Description
Technical field
The invention belongs to biomedicine field, in particular to a kind of chitosan piezoelectric membrane and the preparation method and application thereof.
Background technique
Wound healing is since its popularity is largely studied, and wherein Wound dressing is largely used.According to deposited
The material difference of material can be divided into traditional dressing, artificial synthesized dressing Oh, biological dressing and growth factor dressing etc..These surface of a wound apply
Material is during utilization, because of the characteristic of its material, plays different biological functions, such as creates the hypoxemia ring of the surface of a wound
Border, promotes the regeneration of epidermis, blood vessel, to achieve the effect that wound healing, reduces the workload of medical treatment and the demand of patient.
In recent years, chitosan (Chitosan) is due to itself nontoxic, biodegradable, good biocompatibility,
There is good mechanical performance, anticoagulation and anti-corrosive antibacterial with good film forming, and after having the function of film forming, in biology
Medical aspect is concerned.108034087 A of CN is different to be formed according to the different proportion of different chitosan and glycerol
Chitosan film.Hydrogel is made in chitosan and other macromolecules and applies to the form of wound repair also in extensive utilization.
Piezoelectric material (Piezoelectric materials) is a kind of material with piezoelectric effect, when material by
Inside generates polarization phenomena when the extruding of external force or bending deformation itself, and two apparent surfaces of material occur positive and negative opposite
Charge, to be generated with small Current Voltage.Piezoelectric material be divided into it is organic with inorganic two kinds, inorganic piezoelectric material is divided into pressure
Transistor and two kinds of piezoelectric ceramics, this piezoelectric material usually applies to mechanically.108134538 A researcher of CN uses it
Design scheme, the piezoelectric patches being used in equipment generate deformation, and then generate alternating current and be powered to equipment.In addition, micro- electricity
Stream has applied in the drug delivery of skin.106998889 A researcher of CN promotes its institute with the generation of micro-current
It states being delivered to skin of skin benefit agent and directly affects treatment.Also, existing document first-hand report, micro-current are cured the surface of a wound
The facilitation of conjunction.Present most of piezoelectric materials are all metal materials, and a large amount of physiological-toxicity can be generated by applying on human body;
And the fabulous biocompatibility and good tensile property of chitosan itself apply to human body to piezoelectric material and provide the foundation.
Summary of the invention
Of the invention provides a kind of preparation method of chitosan piezoelectric membrane, which includes the following steps: shell
Glycan, which is dissolved in hexafluoroisopropanol, forms chitosan solution, obtains chitosan piezoelectric membrane after solvent volatilization completely.
Based on method made above, the present invention provides a kind of chitosan piezoelectric membrane that can generate piezoelectric effect, the shell
Glycan piezoelectric membrane has good biocompatibility and tensile property, when being applied to wound repair, accelerates the surface of a wound
Healing;In addition, piezoelectric membrane provided by the invention can solve wound repair in the simple application of daily life
Problem, such as, patient with diabetic feet can directly contact trouble using insole or sole etc. made of this chitosan piezoelectric membrane
It when the product of person's foot, is equivalent to give during its daily walking and squeezes, generate electric current, promote to repair.It is other
Wound at buttocks or back can sit or lie in daily life can effective solution squeeze generate electric current
Promote the effect repaired.
In some preferred embodiments of the present invention, in the chitosan solution mass fraction of chitosan be 0.1%~
5%, due to the slightly solubility of chitosan, form the piezoelectric membrane uniform ground the most that 1% chitosan solution is formed.
In some preferred embodiments of the present invention, chitosan solution is poured into container, is placed in 20 DEG C~50 DEG C
Solvent is volatilized;In some specific embodiments of the present invention, using 37 DEG C or direct room temperature volatilization can obtain shell and gather
Sugared piezoelectric membrane.
Since numerous diseases or other factors will affect the action of patient, such as osteoarthritis, various uncomfortable, old
People and baby etc. can influence the activity performance of body;And in normal human body use process, if being applied without continuous disturbances
Add, what some positions still can not continue gives external pressure to generate electric current.
Magnetic is added in the chitosan solution in some preferred embodiments of the present invention based on the above technical problem
Property substance;It is highly preferred that the magnetisable material is ferriferrous oxide particles.
By adding magnetisable material, a kind of chitosan piezoelectric membrane containing magnetisable material is obtained, by introducing magnetic field hair
Raw device makes it the attraction of particle can squeeze to generate piezoelectricity to chitosan piezoelectric membrane close to the inner portion in the presence of a magnetic field
Effect (referring to Fig. 1) is implemented without and itself gives its external force and can achieve the effect that the same piezoelectric effect and promote to repair.
Based on this, the present invention also provides a kind of medical component, which includes the chitosan piezoelectric membrane and magnetic
Field generator, the magnetic field generator act on magnetisable material, so that chitosan piezoelectric membrane persistently generates piezoelectric effect;It is preferred that
Ground, the magnetic field generator are magnet.
Above-mentioned chitosan piezoelectric membrane and medical component are used for wound repair by the present inventor.
In some preferred embodiments of the present invention, wound repair is made in chitosan piezoelectric membrane by the present inventor
Product.
In some preferred embodiments of the present invention, medical component provided by the invention is used for wound repair equipment.
Compared with prior art, the invention has the following advantages:
1. chitosan piezoelectric membrane provided by the invention has many advantages, such as good biocompatibility, biodegradable, make
It is in wound healing or repairs field with vast prospect, and can sit or lie in daily life can effectively squeeze production
Raw electric current promotes the effect repaired.
2. further, magnetic-particle is added in the present invention in piezoelectric membrane, make its energy in the presence of a magnetic field
By to generate the effect squeezed to film to attracting for magnetic-particle, so that it is not needed itself to give its external force can reach the same
Piezoelectric effect and promote repair effect.Piezoelectric effect is persistently generated in the case where being magnetic and attracting generates micro-current promotion
Wound healing, the position moved or organ or patient are inconvenient on human body has other diseases can not normal activity
In the case of utilization have vast prospect.
Detailed description of the invention
Fig. 1 is the status diagram that the medical component that embodiment 3 provides is used to treat foot's wound healing;
Fig. 2 is the saturating of the piezoelectric membrane of the piezoelectric membrane that embodiment 1 provides and the addition magnetisable material that embodiment 2 provides
Light schematic diagram;
Fig. 3 is the piezoelectric membrane that A4 paper, A4 paper and embodiment 1 provide and the addition magnetisable material that embodiment 2 provides
Piezoelectric membrane light transmittance curve;
Fig. 4 is the piezoelectric membrane that embodiment 1 provided by the invention provides and the addition magnetisable material that embodiment 2 provides
The white light and polarised light schematic diagram of piezoelectric membrane;
Fig. 5 and Fig. 6 is respectively the pressure of the piezoelectric membrane that embodiment 1 provides and the addition magnetisable material that embodiment 2 provides
The column schematic diagram of conductive film tensile stress and elongation strain;
Fig. 7 is the piezoelectric membrane voltage/time curve graph that embodiment 1 obtains;
Fig. 8 is healing state of the mouse wound after with piezoelectric membrane;
Fig. 9 is wounds in mice size statistical chart.
Specific embodiment
The present invention is described in detail with reference to the accompanying drawing.
The preparation method of chitosan piezoelectric membrane
Embodiment 1
200mg Chitosan powder is dissolved in the solution of the hexafluoroisopropanol of 20ml and forms chitosan solution, by chitosan
Solution is poured into the ware of 10cm diameter, degassing, solvent is volatilized under the conditions of being placed in 37 DEG C, it is to be evaporated completely after uniformly put down
The chitosan piezoelectric membrane that whole thickness is about 1mm;It is appreciated that the thickness of chitosan piezoelectric membrane can be according to the bottom surface of container
Long-pending size (size of ware) controls.
Embodiment 2
The ferroso-ferric oxide of 200mg Chitosan powder and 40mg is dissolved in the solution of the hexafluoroisopropanol of 20ml and forms shell
Chitosan solution is poured into big ware by glycan solution, degassing, solvent is volatilized under the conditions of being placed in 37 DEG C, it is to be evaporated completely after
Obtain the chitosan piezoelectric membrane containing ferriferrous oxide particles of uniform ground.
The characterization of chitosan piezoelectric membrane
Embodiment 3
As shown in Fig. 2, being cut into wide 1mm size for what embodiment 1 and embodiment 2 obtained, it is carried out with common A4 paper
Comparison, is all placed in physiological saline and tests its light transmittance at 200nm-800nm.
As a result as shown in figure 3, common A4 paper light transmittance is almost nil, and the light transmittance of simple physiological saline is 100,
And the chitosan piezoelectric membrane that embodiment 1 obtains has good light transmittance, and the piezoelectric membrane that embodiment 2 obtains has well
Light transmittance;Facilitate the visualization for being able to carry out wound in clinical utilization, observes wound healing situation in time.
Embodiment 4
As shown in figure 4, the piezoelectricity for the addition magnetisable material that piezoelectric membrane and embodiment 2 that Example 1 provides provide
Film, under polarised light camera lens, the piezoelectric membrane that embodiment 1 and embodiment 2 obtain can see motley film (five face
Six chromatic graphs, which show, to be not shown), and transparent membrane is presented in the piezoelectric membrane that embodiment 1 and embodiment 2 obtain under white light, it was demonstrated that shell is poly-
Sugared piezoelectric membrane is the film formed by chitosan monomer by Hydrogenbond, fibrosis, illustrates this film by each cellulose
It is formed by connecting, forms good mechanical property.
Embodiment 5
Actual wound utilization in, it is existing in various dressing, such as: gauze, hydrogel etc., sometimes by
It is bad in mechanical property, when treatment of wounds, it is particularly easy to breakage occur and tear to have remnants, meanwhile, patient's
In daily life, since various move causes the destruction of dressing, or fragment is formed in wound not easy-clear, cause secondary damage
Wound.The piezoelectric membrane that embodiment 1 and embodiment 2 are obtained carries out the stretching of mechanical property;Mechanical experimental results are shown such as
Shown in Fig. 5 and Fig. 6, the piezoelectric membrane that embodiment 1 and embodiment 2 obtain is able to maintain preferable tensile property;Specifically handling
It is easy to take down when wound, clears up wound;Secondly, patient not will cause the damage of film in daily life campaign;In addition, this film
With piezoelectric effect, if because piezoelectric effect can be weakened after the bad breakage of mechanical property.
Embodiment 6
The piezoelectric membrane that embodiment 1 obtains is placed on PDMS film and is tested, can be conducive to film can be by
Uniform power generates piezoelectric effect;
Test as the result is shown as shown in Figure 7: when film is bent, has a constant voltage and generate, or not into
Voltage is 0 when row bending.
Chitosan piezoelectric membrane is used for wound healing
Embodiment 7
Piezoelectric membrane applies to animals interview and tests:
Step 1: taking six groups of C57BL/6 mouse, is descended at two on its backside and get the wound that diameter is 12mm with punch
Mouthful;
Step 2: first group of mouse wound is covered with business 3M breathable films as a control group, second group of mouse web portion is placed
There is magnet, third group mouse wound is covered with the piezoelectric membrane that embodiment 1 obtains, and the 4th group of mouse wound is covered with embodiment 1 and obtains
Piezoelectric membrane and its abdomen be placed with magnet, the 5th group of mouse wound is covered with the piezoelectric membrane that embodiment 2 obtains, the 6th group small
Mouse wound is covered with the piezoelectric membrane that embodiment 2 obtains and its abdomen is placed with magnet;In above-mentioned apply pressure conductive film outside it
Portion adds one layer of business 3M breathable films, and is coated the wound of six groups of mouse using bandage finally, prevent mouse it
Between destruction for wound;
Mouse wound healing situation referring to Fig. 8, wound area when to 0 to 20 day counts, as a result such as Fig. 9 institute
Show, * is indicated, P < 0.05;* expression, P < 0.01;* * expression, P < 0.001;6th group with the 5th group of comparison, N > 6.In conjunction with figure
Shown in 8 and Fig. 9,1 chitosan piezoelectric membrane of embodiment has the function of wound healing;If the shell that embodiment 2 obtains is gathered
Sugared piezoelectric membrane applies to wound healing and cooperation magnetic field suction, piezoelectric membrane persistently generate micro-current, to persistently promote wound
The wound healing of mouth.
Embodiment 8
As shown in Figure 1, the chitosan piezoelectric membrane that embodiment 2 obtains is used for instep wound, and it is placed in its sole
On magnet, the quick healing of instep wound is realized.
Above-described is only some embodiments of the present invention.For those of ordinary skill in the art, not
Under the premise of being detached from the invention design, various modifications and improvements can be made, these belong to protection model of the invention
It encloses.
Claims (9)
1. a kind of preparation method of chitosan piezoelectric membrane, it is characterised in that: the preparation method includes the following steps: chitosan
It is dissolved in hexafluoroisopropanol and forms chitosan solution, obtain chitosan piezoelectric membrane after solvent volatilization completely.
2. the preparation method of chitosan piezoelectric membrane according to claim 1, it is characterised in that: in the chitosan solution
Middle addition magnetisable material;Preferably, the magnetisable material is ferriferrous oxide particles.
3. the preparation method of chitosan piezoelectric membrane according to claim 1, it is characterised in that: in the chitosan solution
The mass fraction of chitosan is 0.1%~5%, preferably 1%.
4. the preparation method of chitosan piezoelectric membrane according to claim 1, it is characterised in that: pour into chitosan solution
Into container, it is placed in 20 DEG C~50 DEG C and solvent is volatilized.
5. the chitosan piezoelectric membrane that the method according to claim 3 or 4 is prepared.
6. the chitosan piezoelectric membrane that the method according to claim 11 is prepared.
7. a kind of medical component, it is characterised in that: the component includes chitosan piezoelectric membrane as claimed in claim 6 and magnetic field
Generator, the magnetic field generator act on magnetisable material, so that chitosan piezoelectric membrane persistently generates piezoelectric effect;It is preferred that
Ground, the magnetic field generator are magnet.
8. application of the chitosan piezoelectric membrane according to claim 5 or 6 in preparation wound repair product.
9. application of the medical component in wound repair equipment according to claim 7.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910181096.9A CN110025818A (en) | 2019-03-11 | 2019-03-11 | A kind of chitosan piezoelectric membrane and the preparation method and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910181096.9A CN110025818A (en) | 2019-03-11 | 2019-03-11 | A kind of chitosan piezoelectric membrane and the preparation method and application thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110025818A true CN110025818A (en) | 2019-07-19 |
Family
ID=67235182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910181096.9A Pending CN110025818A (en) | 2019-03-11 | 2019-03-11 | A kind of chitosan piezoelectric membrane and the preparation method and application thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110025818A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110665043A (en) * | 2019-09-24 | 2020-01-10 | 西安理工大学 | Medical dressing and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1730523A (en) * | 2005-08-26 | 2006-02-08 | 浙江大学 | Method for preparing ordered ferriferrous oxide/chitosan nanometre composite material |
CN106075592A (en) * | 2015-05-29 | 2016-11-09 | 杭州弘复医疗科技有限公司 | Multi-functional skin or wound surface combine dressing as reproducibility Graftskin |
CN106380756A (en) * | 2016-10-06 | 2017-02-08 | 常州市鼎升环保科技有限公司 | Preparation method of macromolecule piezoelectric material |
CN108565048A (en) * | 2018-04-18 | 2018-09-21 | 天津大学 | Conformal biodegradable implanted flexibility energy supply device and preparation method thereof |
CN109400931A (en) * | 2018-11-22 | 2019-03-01 | 武汉纺织大学 | It is a kind of to be orientated porous polyunsymfluorethylepiezoelectric piezoelectric film and preparation method thereof |
-
2019
- 2019-03-11 CN CN201910181096.9A patent/CN110025818A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1730523A (en) * | 2005-08-26 | 2006-02-08 | 浙江大学 | Method for preparing ordered ferriferrous oxide/chitosan nanometre composite material |
CN106075592A (en) * | 2015-05-29 | 2016-11-09 | 杭州弘复医疗科技有限公司 | Multi-functional skin or wound surface combine dressing as reproducibility Graftskin |
CN106380756A (en) * | 2016-10-06 | 2017-02-08 | 常州市鼎升环保科技有限公司 | Preparation method of macromolecule piezoelectric material |
CN108565048A (en) * | 2018-04-18 | 2018-09-21 | 天津大学 | Conformal biodegradable implanted flexibility energy supply device and preparation method thereof |
CN109400931A (en) * | 2018-11-22 | 2019-03-01 | 武汉纺织大学 | It is a kind of to be orientated porous polyunsymfluorethylepiezoelectric piezoelectric film and preparation method thereof |
Non-Patent Citations (2)
Title |
---|
HANNINEN, ALEKSI等: "Nanocellulose and chitosan based films as low cost, green piezoelectric materials", 《CARBOHYDRATE POLYMERS》 * |
金征宇等: "《基因与纳米探针-医学分子成像理论与实践 上》", 30 November 2017, 天津科学技术出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110665043A (en) * | 2019-09-24 | 2020-01-10 | 西安理工大学 | Medical dressing and preparation method thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Zhang et al. | Electroactive electrospun nanofibers for tissue engineering | |
Wang et al. | Self-adhesive, stretchable, biocompatible, and conductive nonvolatile eutectogels as wearable conformal strain and pressure sensors and biopotential electrodes for precise health monitoring | |
Niu et al. | Biodegradable silk fibroin-based bio-piezoelectric/triboelectric nanogenerators as self-powered electronic devices | |
Wan et al. | Human body-based self-powered wearable electronics for promoting wound healing driven by biomechanical motions | |
Kao et al. | Self-assisted wound healing using piezoelectric and triboelectric nanogenerators | |
AU2016262720B2 (en) | Expandable wound dressings | |
Wang et al. | Triboelectric nanogenerators-based therapeutic electrical stimulation on skin: from fundamentals to advanced applications | |
CN111744023A (en) | Self-adhesive hydrogel patch with spontaneous electrical property and preparation method and application thereof | |
US20120231063A1 (en) | Dressing comprising active components of centella asiatica and use of the same | |
JP2007522887A (en) | Batteries and their production and use | |
Xia et al. | Electrical stimulation enabled via electrospun piezoelectric polymeric nanofibers for tissue regeneration | |
Ye et al. | A fully biodegradable and biocompatible ionotronic skin for transient electronics | |
Zhang et al. | A conductive multifunctional hydrogel dressing with the synergistic effect of ROS-scavenging and electroactivity for the treatment and sensing of chronic diabetic wounds | |
CN113520721A (en) | Integrated drug-loaded triboelectric nanogenerator paster, and preparation and application thereof | |
Fu et al. | A Self-Powered Hydrogel/Nanogenerator System Accelerates Wound Healing by Electricity-Triggered On-Demand Phosphatase and Tensin Homologue (PTEN) Inhibition | |
Ma et al. | Biophysical sensors based on triboelectric nanogenerators | |
CN110025818A (en) | A kind of chitosan piezoelectric membrane and the preparation method and application thereof | |
Yu et al. | Self-powered biodegradable and antibacterial MoS2-based triboelectric nanogenerators for the acceleration of wound healing in diabetes | |
Li et al. | Kirigami triboelectric spider fibroin microneedle patches for comprehensive joint management | |
Xu et al. | Piezoelectric film promotes skin wound healing with enhanced collagen deposition and vessels regeneration via upregulation of PI3K/AKT | |
Kim et al. | Inhibiting scar formation via wearable multilayer stacked electret patch: self‐creation of persistent and customizable DC electric field for fibrogenic activity restriction | |
Sun et al. | Accelerating wound healing with flexible zinc ion microbatteries coupled with endogenous electrical fields | |
CN110420344B (en) | Wound dressing and preparation method and application thereof | |
CN105461856A (en) | Hydrogel for photon therapy and preparation method of hydrogel | |
CN107929810B (en) | Layer-by-layer self-assembled film and preparation method and application thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190719 |