[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CN110025818A - A kind of chitosan piezoelectric membrane and the preparation method and application thereof - Google Patents

A kind of chitosan piezoelectric membrane and the preparation method and application thereof Download PDF

Info

Publication number
CN110025818A
CN110025818A CN201910181096.9A CN201910181096A CN110025818A CN 110025818 A CN110025818 A CN 110025818A CN 201910181096 A CN201910181096 A CN 201910181096A CN 110025818 A CN110025818 A CN 110025818A
Authority
CN
China
Prior art keywords
chitosan
piezoelectric membrane
piezoelectric
preparation
wound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910181096.9A
Other languages
Chinese (zh)
Inventor
何华成
吴疆
程超群
安颖
朱虹
朱俊逸
胡锦瑜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wenzhou University
Original Assignee
Wenzhou University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wenzhou University filed Critical Wenzhou University
Priority to CN201910181096.9A priority Critical patent/CN110025818A/en
Publication of CN110025818A publication Critical patent/CN110025818A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28Polysaccharides or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/62Compostable, hydrosoluble or hydrodegradable materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention provides a kind of preparation method of chitosan piezoelectric membrane, which, which includes the following steps: to dissolve chitosan in, forms chitosan solution in hexafluoroisopropanol, obtains chitosan piezoelectric membrane after solvent volatilization completely.The chitosan piezoelectric membrane has good biocompatibility and tensile property, when being applied to wound repair, accelerates the healing of the surface of a wound.

Description

A kind of chitosan piezoelectric membrane and the preparation method and application thereof
Technical field
The invention belongs to biomedicine field, in particular to a kind of chitosan piezoelectric membrane and the preparation method and application thereof.
Background technique
Wound healing is since its popularity is largely studied, and wherein Wound dressing is largely used.According to deposited The material difference of material can be divided into traditional dressing, artificial synthesized dressing Oh, biological dressing and growth factor dressing etc..These surface of a wound apply Material is during utilization, because of the characteristic of its material, plays different biological functions, such as creates the hypoxemia ring of the surface of a wound Border, promotes the regeneration of epidermis, blood vessel, to achieve the effect that wound healing, reduces the workload of medical treatment and the demand of patient.
In recent years, chitosan (Chitosan) is due to itself nontoxic, biodegradable, good biocompatibility, There is good mechanical performance, anticoagulation and anti-corrosive antibacterial with good film forming, and after having the function of film forming, in biology Medical aspect is concerned.108034087 A of CN is different to be formed according to the different proportion of different chitosan and glycerol Chitosan film.Hydrogel is made in chitosan and other macromolecules and applies to the form of wound repair also in extensive utilization.
Piezoelectric material (Piezoelectric materials) is a kind of material with piezoelectric effect, when material by Inside generates polarization phenomena when the extruding of external force or bending deformation itself, and two apparent surfaces of material occur positive and negative opposite Charge, to be generated with small Current Voltage.Piezoelectric material be divided into it is organic with inorganic two kinds, inorganic piezoelectric material is divided into pressure Transistor and two kinds of piezoelectric ceramics, this piezoelectric material usually applies to mechanically.108134538 A researcher of CN uses it Design scheme, the piezoelectric patches being used in equipment generate deformation, and then generate alternating current and be powered to equipment.In addition, micro- electricity Stream has applied in the drug delivery of skin.106998889 A researcher of CN promotes its institute with the generation of micro-current It states being delivered to skin of skin benefit agent and directly affects treatment.Also, existing document first-hand report, micro-current are cured the surface of a wound The facilitation of conjunction.Present most of piezoelectric materials are all metal materials, and a large amount of physiological-toxicity can be generated by applying on human body; And the fabulous biocompatibility and good tensile property of chitosan itself apply to human body to piezoelectric material and provide the foundation.
Summary of the invention
Of the invention provides a kind of preparation method of chitosan piezoelectric membrane, which includes the following steps: shell Glycan, which is dissolved in hexafluoroisopropanol, forms chitosan solution, obtains chitosan piezoelectric membrane after solvent volatilization completely.
Based on method made above, the present invention provides a kind of chitosan piezoelectric membrane that can generate piezoelectric effect, the shell Glycan piezoelectric membrane has good biocompatibility and tensile property, when being applied to wound repair, accelerates the surface of a wound Healing;In addition, piezoelectric membrane provided by the invention can solve wound repair in the simple application of daily life Problem, such as, patient with diabetic feet can directly contact trouble using insole or sole etc. made of this chitosan piezoelectric membrane It when the product of person's foot, is equivalent to give during its daily walking and squeezes, generate electric current, promote to repair.It is other Wound at buttocks or back can sit or lie in daily life can effective solution squeeze generate electric current Promote the effect repaired.
In some preferred embodiments of the present invention, in the chitosan solution mass fraction of chitosan be 0.1%~ 5%, due to the slightly solubility of chitosan, form the piezoelectric membrane uniform ground the most that 1% chitosan solution is formed.
In some preferred embodiments of the present invention, chitosan solution is poured into container, is placed in 20 DEG C~50 DEG C Solvent is volatilized;In some specific embodiments of the present invention, using 37 DEG C or direct room temperature volatilization can obtain shell and gather Sugared piezoelectric membrane.
Since numerous diseases or other factors will affect the action of patient, such as osteoarthritis, various uncomfortable, old People and baby etc. can influence the activity performance of body;And in normal human body use process, if being applied without continuous disturbances Add, what some positions still can not continue gives external pressure to generate electric current.
Magnetic is added in the chitosan solution in some preferred embodiments of the present invention based on the above technical problem Property substance;It is highly preferred that the magnetisable material is ferriferrous oxide particles.
By adding magnetisable material, a kind of chitosan piezoelectric membrane containing magnetisable material is obtained, by introducing magnetic field hair Raw device makes it the attraction of particle can squeeze to generate piezoelectricity to chitosan piezoelectric membrane close to the inner portion in the presence of a magnetic field Effect (referring to Fig. 1) is implemented without and itself gives its external force and can achieve the effect that the same piezoelectric effect and promote to repair.
Based on this, the present invention also provides a kind of medical component, which includes the chitosan piezoelectric membrane and magnetic Field generator, the magnetic field generator act on magnetisable material, so that chitosan piezoelectric membrane persistently generates piezoelectric effect;It is preferred that Ground, the magnetic field generator are magnet.
Above-mentioned chitosan piezoelectric membrane and medical component are used for wound repair by the present inventor.
In some preferred embodiments of the present invention, wound repair is made in chitosan piezoelectric membrane by the present inventor Product.
In some preferred embodiments of the present invention, medical component provided by the invention is used for wound repair equipment.
Compared with prior art, the invention has the following advantages:
1. chitosan piezoelectric membrane provided by the invention has many advantages, such as good biocompatibility, biodegradable, make It is in wound healing or repairs field with vast prospect, and can sit or lie in daily life can effectively squeeze production Raw electric current promotes the effect repaired.
2. further, magnetic-particle is added in the present invention in piezoelectric membrane, make its energy in the presence of a magnetic field By to generate the effect squeezed to film to attracting for magnetic-particle, so that it is not needed itself to give its external force can reach the same Piezoelectric effect and promote repair effect.Piezoelectric effect is persistently generated in the case where being magnetic and attracting generates micro-current promotion Wound healing, the position moved or organ or patient are inconvenient on human body has other diseases can not normal activity In the case of utilization have vast prospect.
Detailed description of the invention
Fig. 1 is the status diagram that the medical component that embodiment 3 provides is used to treat foot's wound healing;
Fig. 2 is the saturating of the piezoelectric membrane of the piezoelectric membrane that embodiment 1 provides and the addition magnetisable material that embodiment 2 provides Light schematic diagram;
Fig. 3 is the piezoelectric membrane that A4 paper, A4 paper and embodiment 1 provide and the addition magnetisable material that embodiment 2 provides Piezoelectric membrane light transmittance curve;
Fig. 4 is the piezoelectric membrane that embodiment 1 provided by the invention provides and the addition magnetisable material that embodiment 2 provides The white light and polarised light schematic diagram of piezoelectric membrane;
Fig. 5 and Fig. 6 is respectively the pressure of the piezoelectric membrane that embodiment 1 provides and the addition magnetisable material that embodiment 2 provides The column schematic diagram of conductive film tensile stress and elongation strain;
Fig. 7 is the piezoelectric membrane voltage/time curve graph that embodiment 1 obtains;
Fig. 8 is healing state of the mouse wound after with piezoelectric membrane;
Fig. 9 is wounds in mice size statistical chart.
Specific embodiment
The present invention is described in detail with reference to the accompanying drawing.
The preparation method of chitosan piezoelectric membrane
Embodiment 1
200mg Chitosan powder is dissolved in the solution of the hexafluoroisopropanol of 20ml and forms chitosan solution, by chitosan Solution is poured into the ware of 10cm diameter, degassing, solvent is volatilized under the conditions of being placed in 37 DEG C, it is to be evaporated completely after uniformly put down The chitosan piezoelectric membrane that whole thickness is about 1mm;It is appreciated that the thickness of chitosan piezoelectric membrane can be according to the bottom surface of container Long-pending size (size of ware) controls.
Embodiment 2
The ferroso-ferric oxide of 200mg Chitosan powder and 40mg is dissolved in the solution of the hexafluoroisopropanol of 20ml and forms shell Chitosan solution is poured into big ware by glycan solution, degassing, solvent is volatilized under the conditions of being placed in 37 DEG C, it is to be evaporated completely after Obtain the chitosan piezoelectric membrane containing ferriferrous oxide particles of uniform ground.
The characterization of chitosan piezoelectric membrane
Embodiment 3
As shown in Fig. 2, being cut into wide 1mm size for what embodiment 1 and embodiment 2 obtained, it is carried out with common A4 paper Comparison, is all placed in physiological saline and tests its light transmittance at 200nm-800nm.
As a result as shown in figure 3, common A4 paper light transmittance is almost nil, and the light transmittance of simple physiological saline is 100, And the chitosan piezoelectric membrane that embodiment 1 obtains has good light transmittance, and the piezoelectric membrane that embodiment 2 obtains has well Light transmittance;Facilitate the visualization for being able to carry out wound in clinical utilization, observes wound healing situation in time.
Embodiment 4
As shown in figure 4, the piezoelectricity for the addition magnetisable material that piezoelectric membrane and embodiment 2 that Example 1 provides provide Film, under polarised light camera lens, the piezoelectric membrane that embodiment 1 and embodiment 2 obtain can see motley film (five face Six chromatic graphs, which show, to be not shown), and transparent membrane is presented in the piezoelectric membrane that embodiment 1 and embodiment 2 obtain under white light, it was demonstrated that shell is poly- Sugared piezoelectric membrane is the film formed by chitosan monomer by Hydrogenbond, fibrosis, illustrates this film by each cellulose It is formed by connecting, forms good mechanical property.
Embodiment 5
Actual wound utilization in, it is existing in various dressing, such as: gauze, hydrogel etc., sometimes by It is bad in mechanical property, when treatment of wounds, it is particularly easy to breakage occur and tear to have remnants, meanwhile, patient's In daily life, since various move causes the destruction of dressing, or fragment is formed in wound not easy-clear, cause secondary damage Wound.The piezoelectric membrane that embodiment 1 and embodiment 2 are obtained carries out the stretching of mechanical property;Mechanical experimental results are shown such as Shown in Fig. 5 and Fig. 6, the piezoelectric membrane that embodiment 1 and embodiment 2 obtain is able to maintain preferable tensile property;Specifically handling It is easy to take down when wound, clears up wound;Secondly, patient not will cause the damage of film in daily life campaign;In addition, this film With piezoelectric effect, if because piezoelectric effect can be weakened after the bad breakage of mechanical property.
Embodiment 6
The piezoelectric membrane that embodiment 1 obtains is placed on PDMS film and is tested, can be conducive to film can be by Uniform power generates piezoelectric effect;
Test as the result is shown as shown in Figure 7: when film is bent, has a constant voltage and generate, or not into Voltage is 0 when row bending.
Chitosan piezoelectric membrane is used for wound healing
Embodiment 7
Piezoelectric membrane applies to animals interview and tests:
Step 1: taking six groups of C57BL/6 mouse, is descended at two on its backside and get the wound that diameter is 12mm with punch Mouthful;
Step 2: first group of mouse wound is covered with business 3M breathable films as a control group, second group of mouse web portion is placed There is magnet, third group mouse wound is covered with the piezoelectric membrane that embodiment 1 obtains, and the 4th group of mouse wound is covered with embodiment 1 and obtains Piezoelectric membrane and its abdomen be placed with magnet, the 5th group of mouse wound is covered with the piezoelectric membrane that embodiment 2 obtains, the 6th group small Mouse wound is covered with the piezoelectric membrane that embodiment 2 obtains and its abdomen is placed with magnet;In above-mentioned apply pressure conductive film outside it Portion adds one layer of business 3M breathable films, and is coated the wound of six groups of mouse using bandage finally, prevent mouse it Between destruction for wound;
Mouse wound healing situation referring to Fig. 8, wound area when to 0 to 20 day counts, as a result such as Fig. 9 institute Show, * is indicated, P < 0.05;* expression, P < 0.01;* * expression, P < 0.001;6th group with the 5th group of comparison, N > 6.In conjunction with figure Shown in 8 and Fig. 9,1 chitosan piezoelectric membrane of embodiment has the function of wound healing;If the shell that embodiment 2 obtains is gathered Sugared piezoelectric membrane applies to wound healing and cooperation magnetic field suction, piezoelectric membrane persistently generate micro-current, to persistently promote wound The wound healing of mouth.
Embodiment 8
As shown in Figure 1, the chitosan piezoelectric membrane that embodiment 2 obtains is used for instep wound, and it is placed in its sole On magnet, the quick healing of instep wound is realized.
Above-described is only some embodiments of the present invention.For those of ordinary skill in the art, not Under the premise of being detached from the invention design, various modifications and improvements can be made, these belong to protection model of the invention It encloses.

Claims (9)

1. a kind of preparation method of chitosan piezoelectric membrane, it is characterised in that: the preparation method includes the following steps: chitosan It is dissolved in hexafluoroisopropanol and forms chitosan solution, obtain chitosan piezoelectric membrane after solvent volatilization completely.
2. the preparation method of chitosan piezoelectric membrane according to claim 1, it is characterised in that: in the chitosan solution Middle addition magnetisable material;Preferably, the magnetisable material is ferriferrous oxide particles.
3. the preparation method of chitosan piezoelectric membrane according to claim 1, it is characterised in that: in the chitosan solution The mass fraction of chitosan is 0.1%~5%, preferably 1%.
4. the preparation method of chitosan piezoelectric membrane according to claim 1, it is characterised in that: pour into chitosan solution Into container, it is placed in 20 DEG C~50 DEG C and solvent is volatilized.
5. the chitosan piezoelectric membrane that the method according to claim 3 or 4 is prepared.
6. the chitosan piezoelectric membrane that the method according to claim 11 is prepared.
7. a kind of medical component, it is characterised in that: the component includes chitosan piezoelectric membrane as claimed in claim 6 and magnetic field Generator, the magnetic field generator act on magnetisable material, so that chitosan piezoelectric membrane persistently generates piezoelectric effect;It is preferred that Ground, the magnetic field generator are magnet.
8. application of the chitosan piezoelectric membrane according to claim 5 or 6 in preparation wound repair product.
9. application of the medical component in wound repair equipment according to claim 7.
CN201910181096.9A 2019-03-11 2019-03-11 A kind of chitosan piezoelectric membrane and the preparation method and application thereof Pending CN110025818A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910181096.9A CN110025818A (en) 2019-03-11 2019-03-11 A kind of chitosan piezoelectric membrane and the preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910181096.9A CN110025818A (en) 2019-03-11 2019-03-11 A kind of chitosan piezoelectric membrane and the preparation method and application thereof

Publications (1)

Publication Number Publication Date
CN110025818A true CN110025818A (en) 2019-07-19

Family

ID=67235182

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910181096.9A Pending CN110025818A (en) 2019-03-11 2019-03-11 A kind of chitosan piezoelectric membrane and the preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN110025818A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110665043A (en) * 2019-09-24 2020-01-10 西安理工大学 Medical dressing and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1730523A (en) * 2005-08-26 2006-02-08 浙江大学 Method for preparing ordered ferriferrous oxide/chitosan nanometre composite material
CN106075592A (en) * 2015-05-29 2016-11-09 杭州弘复医疗科技有限公司 Multi-functional skin or wound surface combine dressing as reproducibility Graftskin
CN106380756A (en) * 2016-10-06 2017-02-08 常州市鼎升环保科技有限公司 Preparation method of macromolecule piezoelectric material
CN108565048A (en) * 2018-04-18 2018-09-21 天津大学 Conformal biodegradable implanted flexibility energy supply device and preparation method thereof
CN109400931A (en) * 2018-11-22 2019-03-01 武汉纺织大学 It is a kind of to be orientated porous polyunsymfluorethylepiezoelectric piezoelectric film and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1730523A (en) * 2005-08-26 2006-02-08 浙江大学 Method for preparing ordered ferriferrous oxide/chitosan nanometre composite material
CN106075592A (en) * 2015-05-29 2016-11-09 杭州弘复医疗科技有限公司 Multi-functional skin or wound surface combine dressing as reproducibility Graftskin
CN106380756A (en) * 2016-10-06 2017-02-08 常州市鼎升环保科技有限公司 Preparation method of macromolecule piezoelectric material
CN108565048A (en) * 2018-04-18 2018-09-21 天津大学 Conformal biodegradable implanted flexibility energy supply device and preparation method thereof
CN109400931A (en) * 2018-11-22 2019-03-01 武汉纺织大学 It is a kind of to be orientated porous polyunsymfluorethylepiezoelectric piezoelectric film and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HANNINEN, ALEKSI等: "Nanocellulose and chitosan based films as low cost, green piezoelectric materials", 《CARBOHYDRATE POLYMERS》 *
金征宇等: "《基因与纳米探针-医学分子成像理论与实践 上》", 30 November 2017, 天津科学技术出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110665043A (en) * 2019-09-24 2020-01-10 西安理工大学 Medical dressing and preparation method thereof

Similar Documents

Publication Publication Date Title
Zhang et al. Electroactive electrospun nanofibers for tissue engineering
Wang et al. Self-adhesive, stretchable, biocompatible, and conductive nonvolatile eutectogels as wearable conformal strain and pressure sensors and biopotential electrodes for precise health monitoring
Niu et al. Biodegradable silk fibroin-based bio-piezoelectric/triboelectric nanogenerators as self-powered electronic devices
Wan et al. Human body-based self-powered wearable electronics for promoting wound healing driven by biomechanical motions
Kao et al. Self-assisted wound healing using piezoelectric and triboelectric nanogenerators
AU2016262720B2 (en) Expandable wound dressings
Wang et al. Triboelectric nanogenerators-based therapeutic electrical stimulation on skin: from fundamentals to advanced applications
CN111744023A (en) Self-adhesive hydrogel patch with spontaneous electrical property and preparation method and application thereof
US20120231063A1 (en) Dressing comprising active components of centella asiatica and use of the same
JP2007522887A (en) Batteries and their production and use
Xia et al. Electrical stimulation enabled via electrospun piezoelectric polymeric nanofibers for tissue regeneration
Ye et al. A fully biodegradable and biocompatible ionotronic skin for transient electronics
Zhang et al. A conductive multifunctional hydrogel dressing with the synergistic effect of ROS-scavenging and electroactivity for the treatment and sensing of chronic diabetic wounds
CN113520721A (en) Integrated drug-loaded triboelectric nanogenerator paster, and preparation and application thereof
Fu et al. A Self-Powered Hydrogel/Nanogenerator System Accelerates Wound Healing by Electricity-Triggered On-Demand Phosphatase and Tensin Homologue (PTEN) Inhibition
Ma et al. Biophysical sensors based on triboelectric nanogenerators
CN110025818A (en) A kind of chitosan piezoelectric membrane and the preparation method and application thereof
Yu et al. Self-powered biodegradable and antibacterial MoS2-based triboelectric nanogenerators for the acceleration of wound healing in diabetes
Li et al. Kirigami triboelectric spider fibroin microneedle patches for comprehensive joint management
Xu et al. Piezoelectric film promotes skin wound healing with enhanced collagen deposition and vessels regeneration via upregulation of PI3K/AKT
Kim et al. Inhibiting scar formation via wearable multilayer stacked electret patch: self‐creation of persistent and customizable DC electric field for fibrogenic activity restriction
Sun et al. Accelerating wound healing with flexible zinc ion microbatteries coupled with endogenous electrical fields
CN110420344B (en) Wound dressing and preparation method and application thereof
CN105461856A (en) Hydrogel for photon therapy and preparation method of hydrogel
CN107929810B (en) Layer-by-layer self-assembled film and preparation method and application thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20190719