CN118924274A - A display system and method for intracranial pressure data - Google Patents
A display system and method for intracranial pressure data Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/03—Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure ; Measuring pressure in body tissues or organs
- A61B5/031—Intracranial pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6868—Brain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
- A61B5/7445—Display arrangements, e.g. multiple display units
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Abstract
The application provides a display system and a method for intracranial pressure data, which relate to the technical field of medical appliances, and comprise the following steps: the implanted intracranial pressure monitoring sensor comprises an implanted intracranial pressure monitoring sensor probe, a catheter, a cover plate, a battery, an implanted flexible circuit board and a shell, and can be completely implanted into brain tissue with the catheter to ensure the accuracy of pressure monitoring. The cover plate and the shell which are packaged with the battery and the implanted flexible circuit board are fixed between the scalp and the skull, so that the internal circuit and the battery are protected from external pollution and interference. The implanted flexible circuit board is provided with a wireless communication module, and the battery is connected with the implanted flexible circuit board; the wireless communication module is in communication connection with the extracorporeal monitor in a wireless communication mode. The wireless communication is adopted, and the battery is used for supplying power, so that potential safety hazards are reduced, and the real-time performance and accuracy of data transmission are improved.
Description
Technical Field
The application relates to the technical field of medical equipment, in particular to a system and a method for displaying intracranial pressure data.
Background
With the continued advancement of medical technology, the importance of intracranial pressure data in the medical field is increasingly prominent. The intracranial pressure data not only directly reflects the intracranial pressure state, but also provides a critical basis for a clinician in treating serious diseases such as craniocerebral trauma and the like by the objectivity and quantification characteristics of the intracranial pressure data.
Currently, intracranial pressure data display systems rely on physical media such as optical fibers, wires, and the like to connect intracranial sensors to an external detection device to display intracranial pressure data.
But the physical medium connected with the outside breaks the natural barrier in the cranium, so that microorganisms such as bacteria have invasive channels, the risk of intracranial infection is increased, and the potential safety hazard is increased. And in the intracranial pressure data transmission process, the intracranial pressure data transmission process can be influenced by factors such as wire quality, connection stability and the like, so that the real-time performance and accuracy of the data transmission are poor.
Disclosure of Invention
In view of the above problems, the present application provides a system and a method for displaying intracranial pressure data, which are used for reducing the potential safety hazard of displaying intracranial pressure data and improving the real-time performance and accuracy of data transmission. The specific scheme is as follows:
A first aspect of the present application provides a display system for intracranial pressure data, comprising: the device comprises an implanted intracranial pressure monitoring sensor and an external monitor, wherein the implanted intracranial pressure monitoring sensor comprises an implanted intracranial pressure monitoring sensor probe, a catheter, a cover plate, a battery, an implanted flexible circuit board and a shell, the implanted flexible circuit board is provided with a wireless communication module, and the external monitor is provided with a display screen;
The implanted intracranial pressure monitoring sensor probe is provided with a signal transmission line, and the signal transmission line is connected with the implanted flexible circuit board after sequentially passing through the catheter and the cover plate;
the battery and the implanted flexible circuit board are both arranged in the shell, the cover plate can be combined with the shell to form a closed cavity, and the battery is connected with the implanted flexible circuit board;
the wireless communication module is in communication connection with the extracorporeal monitor in a wireless communication mode.
In one possible implementation, the implanted intracranial pressure monitoring sensor probe comprises a probe plug and at least one acquisition unit, wherein the acquisition units are sequentially arranged along the catheter, and each acquisition unit comprises a pressure sensor chip, a chip coating, a signal transmission line and a metal protection frame;
the probe plug is arranged at the head of the implanted intracranial pressure monitoring sensor probe;
The pressure sensor chip, the chip coating and the signal transmission line are all arranged in the metal protection frame, the chip coating covers the pressure sensor chip, and the pressure sensor chip is connected with the signal transmission line;
The metal protection frame is connected with the catheter.
In one possible implementation, the pressure sensor chip includes a pressure sensitive membrane, a piezoresistor and an electrode, the piezoresistor is connected with the electrode, and the pressure sensitive membrane is square;
When the pressure sensor chip is a full-bridge chip, the pressure sensor chip comprises four piezoresistors and four electrodes, and each piezoresistor is respectively arranged at the midpoint of each side of the pressure sensitive film;
When the pressure sensor chip is a half-bridge chip, the pressure sensor chip comprises two piezoresistors and three electrodes, and each piezoresistor is respectively arranged at the middle points of two adjacent sides of the pressure sensitive film.
In one possible implementation, the metal protection frame is in a circular tube shape, and a metal frame through hole and a metal frame window are arranged on the side wall of the metal protection frame;
the pressure sensor chip, the chip coating and the signal transmission line are all arranged in the metal protection frame;
The metal frame window is arranged right above the pressure sensitive film, and the area of the metal frame window is not smaller than the area of the pressure sensitive film.
In one possible implementation, the implantable flexible circuit board includes a plurality of device solder plates, each of the device solder plates being connected by a connecting strap.
In one possible implementation, the device welding plate includes a power management module, a full bridge module, an amplifying module, a filtering module, a single chip microcomputer, and a wireless communication module;
The battery is connected with the power management module;
the pressure sensor chip is respectively connected with the power management module and the full-bridge module;
The full-bridge module is connected with the amplifying module;
the amplifying module is connected with the filtering module;
the filtering module is connected with the singlechip;
The singlechip is connected with the wireless communication module.
In one possible implementation, when the pressure sensor chip is a half-bridge chip, the full-bridge module includes two fixed-value resistors.
In one possible implementation, each of the acquisition units further comprises a temperature sensor chip, which is connected to the amplifying module.
A second aspect of the present application provides a method for displaying intracranial pressure data, applied to any one of the above intracranial pressure data display systems, the method comprising:
The in-vitro monitor sends a sampling instruction to the wireless communication module of the implanted flexible circuit board, wherein the sampling instruction is used for indicating the sampling frequency;
the wireless communication module of the implanted flexible circuit board sends the sampling instruction to the implanted intracranial pressure monitoring sensor probe through the signal transmission line;
The implanted intracranial pressure monitoring sensor probe collects intracranial pressure data based on the sampling instruction and sends the intracranial pressure data to the wireless communication module of the implanted flexible circuit board through the signal transmission line;
the implanted flexible circuit board sends the received intracranial pressure data to the display screen of the extracorporeal monitor for display through the wireless communication module.
In one possible implementation, the device welding plate includes a power management module, a full bridge module, an amplifying module, a filtering module, a single chip microcomputer, and a wireless communication module; the battery is connected with the power management module; the pressure sensor chip is respectively connected with the power management module and the full bridge module; the full-bridge module is connected with the amplifying module; the amplifying module is connected with the filtering module; the filtering module is connected with the singlechip; the singlechip is connected with the wireless communication module;
The wireless communication module of the implanted intracranial pressure monitoring sensor probe for transmitting the intracranial pressure data to the implanted flexible circuit board via the signal transmission line, comprising:
The implanted intracranial pressure monitoring sensor probe sends the intracranial pressure data to the full bridge module of the implanted flexible circuit board through the signal transmission line;
The full bridge module converts the voltage signal of the intracranial pressure data and sends the intracranial pressure data converted by the voltage signal to the amplifying module;
The amplifying module amplifies the converted intracranial pressure data and sends the amplified intracranial pressure data to the filtering module;
The filtering module filters the amplified intracranial pressure data and sends the filtered intracranial pressure data to the singlechip;
And the singlechip performs digital signal conversion on the filtered intracranial pressure data. And transmitting the intracranial pressure data after digital signal conversion to the wireless communication module of the implanted flexible circuit board.
By means of the technical scheme, the intracranial pressure data display system and method provided by the application comprise the following steps: the implanted intracranial pressure monitoring sensor comprises an implanted intracranial pressure monitoring sensor probe, a catheter, a cover plate, a battery, an implanted flexible circuit board and a shell, and can be completely implanted into brain tissue with the catheter, so that the intracranial pressure monitoring accuracy is ensured. The implanted flexible circuit board is provided with a wireless communication module, and the extracorporeal monitor is provided with a display screen; the implanted intracranial pressure monitoring sensor probe is provided with a signal transmission line, and the signal transmission line is connected with the implanted flexible circuit board after sequentially passing through the guide pipe and the cover plate; the battery and the implanted flexible circuit board are arranged in the shell, the cover plate and the shell can be combined to form a closed cavity, the cover plate and the shell which are packaged with the battery and the implanted flexible circuit board are fixed between the scalp and the skull, the internal circuit and the battery are protected from external pollution and interference, and the infection risk is reduced. The battery is connected with the implanted flexible circuit board; the wireless communication module is in communication connection with the extracorporeal monitor in a wireless communication mode. The wireless communication is adopted, so that the physical connection with the outside is completely removed, the complication risk caused by the existence of a lead is greatly reduced, the battery is used for supplying power, the real-time continuous transmission of data can be realized, the external interference is not easy to occur in the transmission process, and the real-time performance and the accuracy of the data transmission are improved.
Drawings
The above and other features, advantages, and aspects of embodiments of the present disclosure will become more apparent by reference to the following detailed description when taken in conjunction with the accompanying drawings. The same or similar reference numbers will be used throughout the drawings to refer to the same or like elements. It should be understood that the figures are schematic and that elements and components are not necessarily drawn to scale.
FIG. 1 is a schematic diagram of a display system for intracranial pressure data according to an embodiment of the present application;
FIG. 2 is a schematic diagram of an implantable intracranial pressure monitoring sensor according to an embodiment of the present application;
FIG. 3 is a schematic diagram of an exploded view of an implantable intracranial pressure monitoring sensor probe according to an embodiment of the present application;
FIG. 4 is a schematic diagram of an implantable intracranial pressure monitoring sensor probe according to an embodiment of the present application;
FIG. 5 is a schematic diagram of a pressure sensor chip according to an embodiment of the present application;
FIG. 6 is a schematic diagram of another pressure sensor chip according to an embodiment of the present application;
fig. 7 is a schematic structural diagram of a metal protection frame according to an embodiment of the present application;
fig. 8 is a schematic structural diagram of an implantable flexible circuit board according to an embodiment of the present application;
FIG. 9 is a schematic structural view of a device bonding board according to an embodiment of the present application;
fig. 10 is a flowchart of a method for displaying intracranial pressure data according to an embodiment of the present application.
Reference numerals:
100-an implanted intracranial pressure monitoring sensor; 101-an implanted intracranial pressure monitoring sensor probe; 1011-probe plug; 1012-an acquisition unit; 10121-a pressure sensor chip; 101211-pressure sensitive membranes; 101212 piezoresistors; 101213 electrodes; 10122-chip coating; 10123-signal transmission line; 10124-a metal protective frame; 101241-metal frame through holes; 101242-metal frame windowing; 10125-a temperature sensor chip; 102-a catheter; 103-cover plate; 104-a battery; 105-an implantable flexible circuit board; 1051—device solder plate; 10511-power management module; 10512-a wireless communication module; 10513-full bridge module; 10514-amplification module; 10515-a filtering module; 10516-a single chip microcomputer; 1052-connecting straps; 106-a housing; 200-an in vitro monitor; 201-display screen.
Detailed Description
Embodiments of the present application will be described below with reference to the accompanying drawings in the embodiments of the present application. The terminology used in the description of the embodiments of the application herein is for the purpose of describing particular embodiments of the application only and is not intended to be limiting of the application.
Embodiments of the present application are described below with reference to the accompanying drawings. As one of ordinary skill in the art can know, with the development of technology and the appearance of new scenes, the technical scheme provided by the embodiment of the application is also applicable to similar technical problems.
The terms first, second and the like in the description and in the claims and in the above-described figures, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the terms so used are interchangeable under appropriate circumstances and are merely illustrative of the manner in which embodiments of the application have been described in connection with the description of the objects having the same attributes. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of elements is not necessarily limited to those elements, but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
In order to reduce the potential safety hazard of displaying intracranial pressure data, the real-time performance and the accuracy of data transmission are improved. The application provides a display system of intracranial pressure data, and the display system of intracranial pressure data provided by the application is further described in detail below with reference to the accompanying drawings and the detailed description.
Referring to fig. 1, fig. 1 is a schematic structural diagram of a display system for intracranial pressure data according to an embodiment of the present application, the system includes: the implanted intracranial pressure monitoring sensor 100 and the external monitor 200, wherein the implanted intracranial pressure monitoring sensor 100 comprises an implanted intracranial pressure monitoring sensor probe 101, a catheter 102, a cover plate 103, a battery 104, an implanted flexible circuit board 105 and a shell 106, the implanted flexible circuit board 105 is provided with a wireless communication module 10512, and the external monitor 200 is provided with a display screen 201. The battery 104 and the implanted flexible circuit board 105 are arranged in the shell 106, the cover plate 103 and the shell 106 are combined to form a closed cavity battery 104 and the implanted flexible circuit board 105 is arranged in the shell 106, and the cover plate 103 and the shell 106 are combined to form a closed cavity. The battery 104 is connected to an implanted flexible circuit board 105, and for ease of understanding, reference may be made specifically to fig. 2, where fig. 2 is a schematic structural diagram of an implanted intracranial pressure monitoring sensor according to an embodiment of the present application.
In the present application, the implanted intracranial pressure monitoring sensor 100 can measure intracranial pressure data in a patient. The extracorporeal monitor 200 is used in combination with the implanted intracranial pressure monitoring sensor 100, and can receive, process and display intracranial pressure data, provide important clinical information for doctors, and help to diagnose and treat related diseases in time.
Wherein the implanted intracranial pressure monitoring sensor probe 101 senses changes in intracranial pressure. The implanted intracranial pressure monitoring sensor probe 101 can be fully implanted in brain tissue.
The catheter 102 is an elongated tubular structure, and may be made of a biocompatible, insulating, and flexible material such as nylon or polyurethane. Catheter 102 may provide a protective path for signal transmission line 10123, and may also serve as a guide tool to aid in accurate placement of the sensor probe at a designated location within the cranium, the length of catheter 102 being the depth of implantation within the cranium. The catheter 102 may be fully implanted into brain tissue.
The cover plate 103 and the housing 106 may be made of ceramic material with good biocompatibility or polyether-ether-ketone material, and a closed cavity is formed by welding, gluing, screwing and other modes, so as to protect the electronic components inside from external environment (such as body fluid and bacteria), and enable the embedded flexible circuit board 105 and the battery 104 inside to work in a stable and safe environment. The cavity can be cylindrical with round corners, so that the cavity can be conveniently fixed between the skull and the scalp.
The implanted flex circuit board 105 is an integrated circuit system of the implanted intracranial pressure monitoring sensor 100, and the flexible design facilitates packaging in the cover plate 103 and housing 106.
The wireless communication module 10512 in the implanted flexible circuit board 105 generally employs low power consumption, long distance wireless communication technology (e.g., bluetooth low energy, dedicated medical grade wireless protocol), so that the implanted intracranial pressure monitoring sensor 100 can communicate wirelessly with the extracorporeal monitor 200 without a physical connection, facilitating data transmission and remote monitoring.
The battery 104 may be miniature to facilitate reduced trauma to the patient by minimally invasive surgical implantation while requiring sufficient capacity and long life to provide electrical support for the implanted flexible circuit board 105.
The power management module 10511 steps up, steps down, and stabilizes the voltage provided by the battery 104 to provide an input voltage and a reference voltage.
The display 201 of the extracorporeal monitor 200 generally has an easy-to-read interface and clear image, and can process, analyze and store the received intracranial pressure data, and display information such as intracranial pressure data, a waveform chart, a trend chart and the like, so that a medical staff can conveniently and quickly know the intracranial pressure condition of a patient. Further, the extracorporeal monitor 200 may also be provided with a user interface, which includes keys, a touch screen, and an indicator light, so that medical staff can conveniently set monitoring parameters, check monitoring results, adjust alarm thresholds, etc., to realize accurate monitoring and management of intracranial pressure conditions of patients.
The implanted intracranial pressure monitoring sensor probe 101 has a signal transmission line 10123, the signal transmission line 10123 being connected to an implanted flexible circuit board 105 after passing sequentially through the catheter 102, the cover 103.
In the application, the implanted intracranial pressure monitoring sensor probe 101 comprises a probe plug 1011 and at least one acquisition unit 1012, wherein the acquisition units 1012 are sequentially arranged along the catheter 102, and each acquisition unit 1012 comprises a pressure sensor chip 10121, a chip coating 10122, a signal transmission line 10123 and a metal protection frame 10124. The probe plug 1011 is disposed on the head of the implanted intracranial pressure monitoring sensor probe 101. The pressure sensor chip 10121, the chip coating 10122 and the signal transmission line 10123 are all arranged inside the metal protection frame 10124, the chip coating 10122 covers the pressure sensor chip 10121, and the pressure sensor chip 10121 is connected with the signal transmission line 10123. A metal protective frame 10124 is coupled to the conduit 102. For ease of understanding, reference may be made specifically to fig. 3, where fig. 3 is a schematic diagram illustrating an exploded structure of an implanted intracranial pressure monitoring sensor probe according to an embodiment of the present application.
The probe plug 1011 can be made of an epoxy resin material with harder texture and higher biocompatibility, is hemispherical, is convenient for closing and protecting the inlet of the probe, prevents intracranial tissues or liquid from entering the inside of the probe, and simultaneously avoids invasion of external pollutants.
The implanted intracranial pressure monitoring sensor probe 101 can be configured in a multi-chip manner, i.e. one probe plug 1011 can carry two or more acquisition units 1012, and the acquisition units 1012 are sequentially arranged along the catheter 102, for example: the probe plug 1011, the acquisition unit 1012, the catheter 102, the acquisition unit 1012 and the catheter 102 are fixedly connected in order to acquire the pressure at different positions of the extending direction of the catheter 102. For ease of understanding, reference may be made specifically to fig. 4, where fig. 4 is a schematic structural diagram of an implanted intracranial pressure monitoring sensor probe according to an embodiment of the present application.
The pressure sensor chip 10121 is a silicon-based piezoresistive pressure sensor chip 10121, and can be a full-bridge chip or a half-bridge chip, which is responsible for sensing intracranial pressure change and converting the intracranial pressure change into a measurable electrical signal. The pressure sensor die 10121 includes a pressure sensitive membrane 101211, a piezo-resistor 101212, and an electrode 101213, the piezo-resistor 101212 being connected to the electrode 101213, the pressure sensitive membrane 101211 being square.
Specifically, the pressure sensitive membrane 101211 directly contacts the brain tissue, and when the brain tissue pressure changes, the pressure sensitive membrane 101211 undergoes a slight deformation. The piezoresistor 101212 is embedded in or in intimate contact with the pressure sensitive membrane 101211. The resistance of the varistor 101212 will vary with the pressure applied. The electrode 101213 connects the varistor 101212 to an external circuit to read the change in resistance and convert it into a measurable electrical signal.
In the case where the pressure sensor die 10121 is a full bridge die, the pressure sensor die 10121 includes four piezoresistors 101212 and four electrodes 101213, each of the piezoresistors 101212 being disposed at a midpoint of each side of the pressure sensitive film 101211. At this time, the four piezoresistors 101212 and the corresponding electrodes 101213 form a wheatstone full bridge, and when the pressure sensitive film 101211 is subjected to pressure, the resistance of the four piezoresistors 101212 changes in a specific manner due to the piezoresistive effect of the semiconductor, causing the bridge to output an electrical signal proportional to the pressure. The configuration has the advantages that the influence of environmental factors such as temperature on the measurement result can be eliminated, and the measurement accuracy and stability are improved. For easy understanding, reference may be made specifically to fig. 5, and fig. 5 is a schematic structural diagram of a pressure sensor chip according to an embodiment of the present application.
In the case where the pressure sensor die 10121 is a half-bridge die, the pressure sensor die 10121 includes two piezoresistors 101212 and three electrodes 101213, each piezoresistor 101212 being disposed at a midpoint of two adjacent sides of the pressure sensitive film 101211, respectively. At this time, the two piezoresistors 101212 and the corresponding electrodes 101213 form a wheatstone half bridge, and when the pressure sensitive film 101211 is subjected to pressure, the resistance of the two piezoresistors 101212 changes in a specific manner due to the piezoresistive effect of the semiconductor, causing the bridge to output an electrical signal proportional to the pressure. This configuration, while not as effective as a full bridge chip in eliminating environmental interference, is still able to sense pressure changes and convert them to electrical signals, often for applications where there are stringent cost or space requirements. For easy understanding, reference may be made specifically to fig. 6, and fig. 6 is a schematic structural diagram of a pressure sensor chip according to an embodiment of the present application.
The chip coating 10122 can be made of silicon rubber material with high biocompatibility, compactness, insulation and high elasticity, and is covered on the pressure sensor chip 10121 to play a role in protecting the pressure sensor chip 10121 from corrosion and abrasion in the intracranial environment.
The signal transmission line 10123 needs to have anti-interference capability, and is responsible for transmitting the electric signals sensed by the pressure sensor chip 10121 in the implanted intracranial pressure monitoring sensor probe 101 to the implanted flexible circuit board 105 through the guide tube 102 and the cover plate 103, so as to ensure the stability and accuracy of transmission. The number of signal transmission lines 10123 is multiple, and the number of signal transmission lines 10123 can be determined according to the number of the pressure sensor chips 10121 and the number of the corresponding electrodes 101213.
The metal protection frame 10124 can be made of titanium, titanium alloy, stainless steel and other materials with high biocompatibility, hard texture and corrosion resistance, is in a circular tube shape, is connected with the catheter 102, ensures the stable position of the acquisition unit 1012 in the cranium, protects the pressure sensor chip 10121, the chip coating 10122 and the signal transmission line 10123 from body fluid, tissues or other external factors, and reduces the influence of external electromagnetic interference on signal transmission. The side wall of the metal protection frame 10124 is provided with a metal frame through hole 101241 and a metal frame opening 101242. The pressure sensor chip 10121, the chip coating 10122, and the signal transmission line 10123 are all disposed inside the metal protective frame 10124. The metal framed window 101242 is disposed directly above the pressure sensitive film 101211, and the area of the metal framed window 101242 is not less than the area of the pressure sensitive film 101211. For easy understanding, reference may be made specifically to fig. 7, and fig. 7 is a schematic structural diagram of a metal protection frame according to an embodiment of the present application.
Specifically, the metal frame through holes 101241 are small holes designed on the side wall of the metal protection frame 10124, and the number of glue filling inlets which can be adhered to the guide tube 102 is at least 1. The metal bezel window 101242 is one particular opening in the sidewall of the metal protective bezel 10124 that is designed to be directly associated with the pressure sensitive membrane 101211 in the pressure sensor die 10121. A metal frame window 101242 may be provided directly over the pressure sensitive membrane 101211 to ensure that the pressure sensitive membrane 101211 is able to directly sense external pressure changes, also in an amount of at least 1. The area of the metal frame fenestration 101242 is not less than the area of the pressure sensitive membrane 101211 in order to ensure that the pressure sensitive membrane 101211 is able to receive uniform pressure from all directions, avoiding inaccurate or distorted pressure measurements due to too small fenestration area.
The implantable flexible circuit board 105 includes a plurality of device solder plates 1051, each device solder plate 1051 being connected by a strap 1052.
The device bonding pads 1051 may be circular in shape, each having specific electronic devices bonded thereto, and the devices cooperate to perform a variety of functions.
The connection strap 1052 is used to connect the individual device bonding plates 1051 to ensure smooth transmission of electrical signals therebetween, and the design of the connection strap 1052 also requires flexibility to accommodate bending and twisting of the circuit board.
In the present application, the number of device bonding pads 1051 and straps 1052 in the implantable flexible circuit board 105 is determined by the actual device size and number. May be comprised of four device bonding plates 1051 and three straps 1052, in a "T" shape, with the battery 104 anchor positioned on the uppermost device bonding plate 1051. Miniaturization can be achieved by folding a plurality of straps 1052, first folding the straps 1052 on both sides in opposite directions, and finally folding the middle strap 1052 to secure the battery 104 card in the outermost side of the implantable flexible circuit board 105. For easy understanding, reference may be made specifically to fig. 8, and fig. 8 is a schematic structural diagram of an implantable flexible circuit board according to an embodiment of the present application.
The device bonding board 1051 includes a power management module 10511, a full bridge module 10513, an amplification module 10514, a filtering module 10515, a single chip microcomputer 10516, and a wireless communication module 10512. The battery 104 is connected to a power management module 10511. The pressure sensor chip 10121 is connected to the power management module 10511 and the full bridge module 10513, respectively. The full bridge module 10513 is connected to an amplifying module 10514. When the pressure sensor die 10121 is a half-bridge die, the full-bridge module 10513 includes two fixed-value resistors. The amplification module 10514 is connected to a filtering module 10515. Each acquisition unit 1012 also includes a temperature sensor chip 10125, the temperature sensor chip 10125 being connected to the amplification module 10514. The filtering module 10515 is connected with the single chip microcomputer 10516. The single chip microcomputer 10516 is connected with the wireless communication module 10512. For easy understanding, reference may be made specifically to fig. 9, and fig. 9 is a schematic structural diagram of a device bonding board according to an embodiment of the present application.
In the present application, device bonding plate 1051 enables accurate measurement, processing and wireless transmission of intracranial pressure data through the cooperation of the various modules.
The power management module 10511 can boost, buck, stabilize the voltage provided by the battery 104 and provide an input voltage and a reference voltage, and can provide positive and negative power for the pressure sensor chip 10121 in the implanted intracranial pressure monitoring sensor probe 101.
The full bridge module 10513 is an output circuit of the pressure sensor chip 10121. When the pressure sensor chip 10121 is a half-bridge chip, the full-bridge module 10513 further includes two fixed resistors, and the two fixed resistors, the two piezoresistors 101212 on the pressure sensor chip 10121, and the corresponding electrodes 101213 form a wheatstone full bridge.
The amplification module 10514 receives the weak voltage signal sent by the full bridge module 10513 and can amplify it to a level suitable for subsequent processing (e.g., filtering conversion) by an amplification circuit. In addition, if each acquisition unit 1012 further includes a temperature sensor chip 10125, the temperature signal output by the temperature sensor chip may also be directly connected to the amplifying module 10514 for amplifying.
The temperature sensor chip 10125 may measure an ambient temperature and convert it into an electrical signal. The signal is processed by the amplifying module 10514 and can be read by the singlechip 10516 for temperature compensation or environmental monitoring. The location of the temperature sensor die 10125 may be located in the vicinity of the pressure sensor die 10121. The temperature compensation is to correct the pressure measured by the pressure sensor according to the temperature. This is because the resistance and the piezoresistive coefficient of the piezo-resistor 101212 all change with temperature, and the thermal expansion coefficient difference between the different materials that constitute the pressure sensor chip 10121 also generates thermal stress that is related to temperature, thereby affecting the output of the pressure sensor chip 10121.
The filtering module 10515 is a low-pass filter, which can remove noise and interference in the amplified voltage signal, and improve the signal-to-noise ratio of the signal.
The singlechip 10516 receives the amplified voltage signal sent by the filtering module 10515, and can perform analog-to-digital conversion, serial asynchronous communication, digital clock setting up, power filtering and other configuration circuits, and convert the amplified voltage signal into a digital signal for output.
The wireless communication module 10512 may wirelessly (e.g., by bluetooth) transmit the digital signal converted intracranial pressure data to the extracorporeal monitor 200.
The wireless communication module 10512 is communicatively coupled to the extracorporeal monitor 200 via wireless communication.
The extracorporeal monitor 200 is a medical apparatus having a wireless communication function and capable of continuously monitoring vital signs of a patient, such as intracranial pressure data, heart rate, blood pressure, blood oxygen saturation, respiratory rate, body temperature, etc.
The wireless communication module 10512 establishes connection with the extracorporeal monitor 200 in a wireless communication manner, and is not limited by cables, so that the mobility and comfort of patients are improved, and the risk of cross infection in a hospital environment is reduced. Medical staff can also view patient's vital sign data in real time in different places, even carry out remote medical consultation.
In summary, the present application provides a system for displaying intracranial pressure data, the system comprising: the implanted intracranial pressure monitoring sensor comprises an implanted intracranial pressure monitoring sensor probe, a catheter, a cover plate, a battery, an implanted flexible circuit board and a shell, and can be completely implanted into brain tissue with the catheter, so that an external interface and a potential infection source are reduced. The implanted flexible circuit board is provided with a wireless communication module, and the extracorporeal monitor is provided with a display screen; the implanted intracranial pressure monitoring sensor probe is provided with a signal transmission line, and the signal transmission line is connected with the implanted flexible circuit board after sequentially passing through the guide pipe and the cover plate; the battery and the implanted flexible circuit board are arranged in the shell, the cover plate and the shell can be combined to form a closed cavity, the cover plate and the shell which are packaged with the battery and the implanted flexible circuit board are fixed between the scalp and the skull, the internal circuit and the battery are protected from external pollution and interference, and the infection risk is further reduced. The battery is connected with the implanted flexible circuit board; the wireless communication module is in communication connection with the extracorporeal monitor in a wireless communication mode. The wireless communication is adopted, so that the physical connection with the outside is completely removed, the complication risk caused by the existence of a lead is greatly reduced, the battery is used for supplying power, the real-time continuous transmission of data can be realized, the external interference is not easy to occur in the transmission process, and the real-time performance and the accuracy of the data transmission are improved.
The above-described embodiments of the present application describe in detail the intracranial pressure data display system, and various methods can be applied to the intracranial pressure data display system of the present application, so the method for displaying intracranial pressure data provided by the present application will be described in further detail with reference to the drawings and the detailed description.
Referring to fig. 10, fig. 10 is a flowchart of a method for displaying intracranial pressure data according to an embodiment of the application. The method is applied to the intracranial pressure data display system, and can comprise the following steps:
Step S101: the in-vitro monitor sends a sampling instruction to the wireless communication module of the implanted flexible circuit board, wherein the sampling instruction is used for indicating the sampling frequency.
In the application, the external monitor sends a sampling instruction to the wireless communication module on the implanted flexible circuit board through the wireless communication function of the external monitor, and the sampling instruction contains specific information about the sampling frequency, namely telling the implanted flexible circuit board how fast to collect intracranial pressure data.
Step S102: the wireless communication module of the implanted flexible circuit board sends a sampling instruction to the implanted intracranial pressure monitoring sensor probe through a signal transmission line.
In the application, after the wireless communication module receives the sampling instruction sent by the external monitor, the sampling instruction is forwarded to the intracranial pressure monitoring sensor probe through the signal transmission line inside the implanted flexible circuit board, so that the sampling instruction can be accurately transmitted to the intracranial pressure monitoring sensor probe, and the intracranial pressure data can be collected according to the sampling instruction, thereby avoiding unnecessary data redundancy or insufficient data.
Step S103: the implanted intracranial pressure monitoring sensor probe collects intracranial pressure data based on the sampling instruction and sends the intracranial pressure data to the wireless communication module of the implanted flexible circuit board through the signal transmission line.
In the application, the device welding plate comprises a power management module, a full bridge module, an amplifying module, a filtering module, a singlechip and a wireless communication module. The battery is connected with the power management module. The pressure sensor chip is respectively connected with the power management module and the full bridge module. The full bridge module is connected with the amplifying module. The amplifying module is connected with the filtering module. The filtering module is connected with the singlechip. The singlechip is connected with the wireless communication module. The implanted intracranial pressure monitoring sensor probe transmits intracranial pressure data to the full bridge module of the implanted flexible circuit board through a signal transmission line. The full bridge module converts voltage signals of the intracranial pressure data and sends the intracranial pressure data after the voltage signals are converted to the amplifying module. The amplifying module amplifies the converted intracranial pressure data and sends the amplified intracranial pressure data to the filtering module. The filtering module filters the amplified intracranial pressure data and sends the filtered intracranial pressure data to the singlechip. And the singlechip performs digital signal conversion on the filtered intracranial pressure data. And transmitting the intracranial pressure data after the digital signal conversion to a wireless communication module of the implanted flexible circuit board.
In particular, an implanted intracranial pressure monitoring sensor probe can directly sense changes in intracranial pressure and generate a resistance signal corresponding to the intracranial pressure data. These resistance signals may be sent to the full bridge module of the implantable flex circuit board via signal transmission lines. The full bridge module may receive analog signals from the implanted intracranial pressure monitoring sensor probe and perform voltage signal conversion, which is typically used to improve the stability and linearity of the signals. And sends the converted voltage signal to an amplifying module. The amplifying module receives the weak voltage signal from the full bridge module and amplifies the weak voltage signal so as to improve the signal to noise ratio of the signal and the accuracy of subsequent processing. And sends the amplified voltage signal to a filtering module. And a filtering module: and receiving the amplified voltage signal from the amplifying module, and performing filtering processing to remove noise and interference components in the signal and improve the quality of the signal. And sending the filtered voltage signal to the singlechip. The singlechip receives the voltage signal from the filtering module, performs analog-to-digital conversion, and converts the analog signal into a digital signal. Then, the singlechip can carry out analog-to-digital conversion and serial asynchronous communication to digitally build a clock, power supply filtering and other configuration circuits, and the amplified voltage signals are converted into digital signals and output to the wireless communication module.
Step S104: the implanted flexible circuit board sends the received intracranial pressure data to a display screen of the extracorporeal monitor for display through the wireless communication module.
In the application, the wireless communication module transmits the intracranial pressure data converted by the digital signal to the external monitor in a wireless mode. After receiving the intracranial pressure data converted by the digital signal, the external monitor displays the intracranial pressure data in a digital form through a display screen.
The in vitro monitor may also graphically display intracranial pressure data. Common graphical displays include line graphs, bar graphs, wave graphs, and the like. The patterns can intuitively reflect the change trend of intracranial pressure data and help medical staff to better judge the intracranial pressure condition of a patient. For example, the waveform diagram can display the change of intracranial pressure with time in real time, and medical staff can judge whether the intracranial pressure of a patient is stable or abnormal fluctuation exists by observing the fluctuation and the frequency of the waveform.
Embodiments of the present application also provide a computer program product including computer readable instructions, which when executed on an electronic device, cause the electronic device to implement any of the methods for displaying intracranial pressure data provided by the embodiments of the present application.
The embodiment of the application also provides a computer readable storage medium, which carries one or more computer programs, and when the one or more computer programs are executed by the electronic equipment, the electronic equipment can realize any intracranial pressure data display method provided by the embodiment of the application.
It should be further noted that the above-described apparatus embodiments are merely illustrative, and that the units described as separate units may or may not be physically separate, and that units shown as units may or may not be physical units, may be located in one place, or may be distributed over a plurality of network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the solution of this embodiment. In addition, in the drawings of the embodiment of the device provided by the application, the connection relation between the modules represents that the modules have communication connection, and can be specifically implemented as one or more communication buses or signal lines.
From the above description of the embodiments, it will be apparent to those skilled in the art that the present application may be implemented by means of software plus necessary general purpose hardware, or of course by means of special purpose hardware including application specific integrated circuits, special purpose CPUs, special purpose memories, special purpose components, etc. Generally, functions performed by computer programs can be easily implemented by corresponding hardware, and specific hardware structures for implementing the same functions can be varied, such as analog circuits, digital circuits, or dedicated circuits. But a software program implementation is a preferred embodiment for many more of the cases of the present application. Based on such understanding, the technical solution of the present application may be embodied essentially or in a part contributing to the prior art in the form of a software product stored in a readable storage medium, such as a floppy disk, a usb disk, a removable hard disk, a ROM, a RAM, a magnetic disk or an optical disk of a computer, etc., comprising several instructions for causing a computer device (which may be a personal computer, a training device, a network device, etc.) to perform the method according to the embodiments of the present application.
In the above embodiments, it may be implemented in whole or in part by software, hardware, firmware, or any combination thereof. When implemented in software, may be implemented in whole or in part in the form of a computer program product.
The computer program product includes one or more computer instructions. When loaded and executed on a computer, produces a flow or function in accordance with embodiments of the present application, in whole or in part. The computer may be a general purpose computer, a special purpose computer, a computer network, or other programmable apparatus. The computer instructions may be stored in a computer-readable storage medium or transmitted from one computer-readable storage medium to another computer-readable storage medium, for example, the computer instructions may be transmitted from one website, computer, training device, or data center to another website, computer, training device, or data center via a wired (e.g., coaxial cable, optical fiber, digital Subscriber Line (DSL)) or wireless (e.g., infrared, wireless, microwave, etc.). The computer readable storage medium may be any available medium that can be stored by a computer or a data storage device such as a training device, a data center, or the like that contains an integration of one or more available media. The usable medium may be a magnetic medium (e.g., floppy disk, hard disk, tape), an optical medium (e.g., DVD), or a semiconductor medium (e.g., solid state disk (Solid STATE DISK, SSD)), etc.
Claims (10)
1. A display system for intracranial pressure data, comprising: the device comprises an implanted intracranial pressure monitoring sensor and an external monitor, wherein the implanted intracranial pressure monitoring sensor comprises an implanted intracranial pressure monitoring sensor probe, a catheter, a cover plate, a battery, an implanted flexible circuit board and a shell, the implanted flexible circuit board is provided with a wireless communication module, and the external monitor is provided with a display screen;
The implanted intracranial pressure monitoring sensor probe is provided with a signal transmission line, and the signal transmission line is connected with the implanted flexible circuit board after sequentially passing through the catheter and the cover plate;
The battery and the implanted flexible circuit board are both arranged in the shell, the cover plate and the shell are combined to form a closed cavity, and the battery is connected with the implanted flexible circuit board;
the wireless communication module is in communication connection with the extracorporeal monitor in a wireless communication mode.
2. The intracranial pressure data display system as recited in claim 1, wherein the implantable intracranial pressure monitoring sensor probe comprises a probe plug and at least one acquisition unit, each acquisition unit being arranged in sequence along the catheter, each acquisition unit comprising a pressure sensor chip, a chip coating, a signal transmission line, and a metal protective frame;
the probe plug is arranged at the head of the implanted intracranial pressure monitoring sensor probe;
The pressure sensor chip, the chip coating and the signal transmission line are all arranged in the metal protection frame, the chip coating covers the pressure sensor chip, and the pressure sensor chip is connected with the signal transmission line;
The metal protection frame is connected with the catheter.
3. The intracranial pressure data display system as recited in claim 2, wherein the pressure sensor chip comprises a pressure sensitive membrane, a piezo-resistor and an electrode, the piezo-resistor being connected to the electrode, the pressure sensitive membrane being square;
When the pressure sensor chip is a full-bridge chip, the pressure sensor chip comprises four piezoresistors and four electrodes, and each piezoresistor is respectively arranged at the midpoint of each side of the pressure sensitive film;
When the pressure sensor chip is a half-bridge chip, the pressure sensor chip comprises two piezoresistors and three electrodes, and each piezoresistor is respectively arranged at the middle points of two adjacent sides of the pressure sensitive film.
4. The intracranial pressure data display system as recited in claim 3, wherein the metal protective frame is tubular, and a metal frame through hole and a metal frame window are arranged on the side wall of the metal protective frame;
the pressure sensor chip, the chip coating and the signal transmission line are all arranged in the metal protection frame;
The metal frame window is arranged right above the pressure sensitive film, and the area of the metal frame window is not smaller than the area of the pressure sensitive film.
5. The intracranial pressure data display system as recited in claim 3, wherein the implantable flexible circuit board comprises a plurality of device-solder plates, each of the device-solder plates being connected by a connecting strap.
6. The intracranial pressure data display system as recited in claim 5, wherein the device welding plate comprises a power management module, a full bridge module, an amplifying module, a filtering module, a single chip microcomputer, and a wireless communication module;
The battery is connected with the power management module;
the pressure sensor chip is respectively connected with the power management module and the full-bridge module;
The full-bridge module is connected with the amplifying module;
the amplifying module is connected with the filtering module;
the filtering module is connected with the singlechip;
The singlechip is connected with the wireless communication module.
7. The intracranial pressure data display system as recited in claim 6, wherein the full bridge module comprises two fixed value resistors when the pressure sensor chip is a half bridge chip.
8. The intracranial pressure data display system as recited in claim 6, wherein each acquisition unit further comprises a temperature sensor chip coupled to the amplification module.
9. A method of displaying intracranial pressure data, applied to the display system of intracranial pressure data as recited in any one of claims 1 to 8, the method comprising:
The in-vitro monitor sends a sampling instruction to the wireless communication module of the implanted flexible circuit board, wherein the sampling instruction is used for indicating the sampling frequency;
the wireless communication module of the implanted flexible circuit board sends the sampling instruction to the implanted intracranial pressure monitoring sensor probe through the signal transmission line;
The implanted intracranial pressure monitoring sensor probe collects intracranial pressure data based on the sampling instruction and sends the intracranial pressure data to the wireless communication module of the implanted flexible circuit board through the signal transmission line;
the implanted flexible circuit board sends the received intracranial pressure data to the display screen of the extracorporeal monitor for display through the wireless communication module.
10. The method of claim 9, wherein the device welding plate comprises a power management module, a full bridge module, an amplifying module, a filtering module, a single chip microcomputer, and a wireless communication module; the battery is connected with the power management module; the pressure sensor chip is respectively connected with the power management module and the full bridge module; the full-bridge module is connected with the amplifying module; the amplifying module is connected with the filtering module; the filtering module is connected with the singlechip; the singlechip is connected with the wireless communication module;
The wireless communication module of the implanted intracranial pressure monitoring sensor probe for transmitting the intracranial pressure data to the implanted flexible circuit board via the signal transmission line, comprising:
The implanted intracranial pressure monitoring sensor probe sends the intracranial pressure data to the full bridge module of the implanted flexible circuit board through the signal transmission line;
The full bridge module converts the voltage signal of the intracranial pressure data and sends the intracranial pressure data converted by the voltage signal to the amplifying module;
The amplifying module amplifies the converted intracranial pressure data and sends the amplified intracranial pressure data to the filtering module;
The filtering module filters the amplified intracranial pressure data and sends the filtered intracranial pressure data to the singlechip;
and the singlechip performs digital signal conversion on the filtered intracranial pressure data and sends the intracranial pressure data after digital signal conversion to the wireless communication module of the implanted flexible circuit board.
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| CN202411296247.2A CN118924274A (en) | 2024-09-14 | 2024-09-14 | A display system and method for intracranial pressure data |
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| CN202411296247.2A CN118924274A (en) | 2024-09-14 | 2024-09-14 | A display system and method for intracranial pressure data |
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