CN118845985A

CN118845985A - Composition for improving male sexual function and relieving fatigue and application thereof

Info

Publication number: CN118845985A
Application number: CN202410877408.0A
Authority: CN
Inventors: 邓洪英; 史权; 王小兰
Original assignee: Shanghai Dongli Great Health Research Institute Co ltd
Current assignee: Shanghai Dongli Great Health Research Institute Co ltd
Priority date: 2024-07-02
Filing date: 2024-07-02
Publication date: 2024-10-29

Abstract

The invention provides a composition for improving male sexual function and relieving fatigue and application thereof, wherein the composition for improving male sexual function and relieving fatigue comprises the following raw materials in parts by weight: 5-12 parts of oyster peptide, 1-5 parts of eucommia male flowers, 0.2-0.7 part of tomato seed oil, 0.75-3 parts of pumpkin seed oil, 10-20 parts of ginseng and wolfberry ferment and 3-9 parts of broccoli seed water extract. The composition mainly takes oyster peptide, tomato seed oil, eucommia male flowers, ginseng and wolfberry ferment, pumpkin seed oil and broccoli seed water extract as raw materials, combines according to a certain proportion by virtue of monarch, minister, assistant and guide theory, and performs synergistic interaction on the basis of respective efficacy, and starts from various factors possibly causing sexual function reduction, thereby achieving the effects of improving male sexual function and relieving fatigue.

Description

Composition for improving male sexual function and relieving fatigue and application thereof

Technical Field

The invention relates to the field of health care, in particular to a composition for improving male sexual function and relieving fatigue and application thereof.

Background

The clinical manifestations of male sexual dysfunction are lack of libido, difficulty in erection, premature ejaculation and pain in intercourse, etc., and severe cases can lead to high psychological stress, produce mental depression, and affect life and work.

Traditional Chinese medicine considers that sexual function has close relation with kidney, and kidney is the source of congenital origin and life. If kidney qi is deficient, kidney essence is deficient, sexual function may be decreased. Secondly, the prostate is also involved in sexual function. The position of the prostate is deep in the penis, an important male sexual organ, and if the prostate is inflamed, the symptoms of reduced sexual function are more easily induced at the time of erection of the penis. Furthermore, sexual dysfunction is also associated with immunity. The sexual life process is also the physical overdraft process, and the nutritional ingredients are timely supplemented, so that the deficiency of the body can be made up, the physical strength is enhanced, the fatigue is relieved, and the sexual intercourse time is prolonged. Finally, sex life and emotional stress are also closely related. If the stress is high and the emotion is low, the sexual desire is severely reduced. Conversely, the emotion is positive, the state is full, the sexual desire can be improved, and the morale for fighting and coursing can be generated.

At present, western medicines and traditional Chinese medicines are generally used for conditioning in the market, and the western medicines have quick effect, but can not only generate drug resistance, but also hurt the liver and kidney after long-term administration, so that the male sexual function is further reduced; the traditional Chinese medicine mainly regulates kidney, little attention is paid to regulation of prostate and emotion, and the conditioning period is overlong, so that the compliance of patients is not high.

Therefore, there is a need to develop a product which can improve male sexual function, relieve fatigue, and has high patient compliance without damaging the kidney.

Disclosure of Invention

Aiming at the problems existing in the prior art, the invention provides a composition for improving male sexual function and relieving fatigue and application thereof.

In a first aspect, the invention provides a composition for improving male sexual function and relieving fatigue, which comprises the following raw materials in parts by weight: 5-12 parts of oyster peptide, 1-5 parts of eucommia male flowers, 0.2-0.7 part of tomato seed oil, 0.75-3 parts of pumpkin seed oil, 10-20 parts of ginseng and wolfberry ferment and 3-9 parts of broccoli seed water extract.

Preferably, the composition for improving male sexual function and relieving fatigue comprises the following raw materials in parts by weight: 7-10 parts of oyster peptide, 2-4 parts of eucommia male flowers, 0.3-0.5 part of tomato seed oil, 1.5-2.25 parts of pumpkin seed oil, 15-18 parts of ginseng and wolfberry ferment and 5-8 parts of broccoli seed water extract.

The oyster peptide is small molecular active peptide prepared by taking oyster meat as a raw material and adopting an enzymolysis technology, and active ingredients such as taurine, polysaccharide, mineral matters and the like in the oyster are reserved to the greatest extent. Oyster is called as "milk in sea", "holy fish" and "root source". The description of Ben Cao gang mu: oyster for treating deficiency, strengthening yang, removing toxic substance, invigorating qi and blood, caring skin, and preventing aging. "the components contained in the composition are all helpful for improving male sexual function, for example, arginine is the main component for producing sperm, and promoting reproductive function; taurine can improve the reproductive and nervous functions of human body and has the efficacy of keeping the vitality of the body; zinc has important effects on sexual development, sexual function and generation of germ cells. Oyster peptide is regarded as a monarch drug in the invention.

Eucommia ulmoides male flowers are Du Zhongshu male flowers, contain natural plant components, a large amount of pinoresinol diglucoside and geniposide, have good effects of preventing sexual hyposexuality, and the patients with kidney-yang deficiency mostly have adrenal hypofunction, and eucommia ulmoides has good effects of exciting pituitary-adrenal cortex system and enhancing adrenal cortex function. Can be used in combination with oyster peptide to enhance male sexual function.

Tomato seed oil is refined natural high-quality edible oil extracted from tomato seeds, contains lycopene and various oil-soluble vitamins, can regulate physiological functions and development of men, and can prevent prostate diseases.

Pumpkin seed oil is vegetable oil extracted from pumpkin seeds, and has various health care effects on men, so that the pumpkin seed oil is praised as the guard of men, and is the most commonly used male health care formula in Europe and America at present. The plant sterols, amino acids and the like contained in the pumpkin seed oil are helpful for relieving prostatitis/swelling, frequent urination, urgent urination and the like.

Although the tomato seed oil and the pumpkin seed oil have different substances and action mechanisms, the combination of the tomato seed oil and the pumpkin seed oil can effectively relieve the problem of the prostate, and then improve the male sexual function, and is regarded as an adjuvant.

The ginseng and wolfberry ferment contains ginseng, wolfberry and probiotics, and can tonify qi and blood, improve immunity and relieve fatigue. In addition, the ginseng and wolfberry ferment contains probiotics, and other medicinal and edible components are easier to absorb and can more effectively exert the efficacy under the synergistic effect of the probiotics.

The water extract of broccoli seed is one kind of natural component extracted from broccoli seed and includes hot water extraction, solid-liquid separation, concentration, spray drying and other steps. The aqueous extract of broccoli seeds is usually white to yellowish brown powder and mainly contains active substances such as sulforaphane (sulforaphane) and glucoraphanin (glucoraphanin). The sulforaphane is a powerful antioxidant, and can activate NRF2 signal channel and prevent the nervous system from oxidative damage, thereby improving the emotion of people.

The ginseng and wolfberry ferment can increase physical strength and can enhance the confidence of sexual intercourse; the broccoli seed water extract can improve emotion and increase sexual pleasure of sexual intercourse. The two are combined, so that the sexual function of the male is boosted together by more confidence and pleasure of sexual intercourse, and physical fatigue is relieved, and the male is regarded as an adjuvant.

The composition is prepared from the aspects of tonifying kidney, relieving fatigue, protecting prostate, increasing nutrition, improving emotion and the like, is combined according to a certain proportion, and has the effects of improving male sexual function and relieving fatigue through animal and human body experiments.

According to the composition for improving male sexual function and relieving fatigue provided by the invention, the average relative molecular weight of the oyster peptide is 400-600 Da, the protein content is 95-99%, the zinc content is 0.1-0.2%, and the taurine content is 1.5-2%.

According to the composition for improving male sexual function and relieving fatigue provided by the invention, the ginseng and wolfberry ferment contains ginseng, wolfberry and probiotics, wherein the content of the ginseng and the wolfberry is 12-15%, the content of the wolfberry is 6-8%, and the content of the probiotics is 1-3%.

According to the composition for improving male sexual function and relieving fatigue provided by the invention, the tomato seed oil adopts bulk drugs in the form of tomato seed oil microcapsule powder;

the pumpkin seed oil adopts bulk drugs in the form of pumpkin seed oil microcapsule powder.

According to the composition for improving male sexual function and relieving fatigue provided by the invention, the content of the sulforaphane in the broccoli seed water extract is 4-7%, and the content of the sulforaphane is 16-20%.

In a second aspect, the invention provides the use of the composition for improving male sexual function and relieving fatigue in the preparation of a medicament, health product or food for improving male sexual function and/or relieving fatigue.

Medicaments are generally defined as substances used for preventing, treating, diagnosing diseases or regulating physiological functions of the human body. The composition for improving male sexual function and relieving fatigue can be used for preparing medicines for improving male sexual function and/or relieving fatigue, and can be understood to contain other active ingredients capable of improving male sexual function and/or relieving fatigue related functions and pharmaceutically acceptable auxiliary materials.

Health products, also known as functional foods or dietary supplements, are products intended to supplement or enhance nutrition, promote health, prevent disease, and improve physiological function. Health products generally do not include drugs for treating diseases. That is, the health care product aims at supplementing nutrition, maintaining or enhancing physical health, preventing diseases, but is not used for treating diseases, and the health care product cannot replace balanced diet and healthy life style.

Food is generally defined as any substance that is consumed to meet the nutritional needs of the human body. It includes various natural or processed products intended to provide the human body with the necessary nutrients to support growth, maintain health and perform daily activities such as carbohydrates, fats, proteins, vitamins, minerals and water. Food products are of a wide variety including fruits, vegetables, grains, meats, fish, dairy products, legumes, nuts, and the like. The food may be unprocessed or may be processed to various extents, such as cooking, drying, freezing, canning, etc. In the present invention, the composition for improving male sexual function and relieving fatigue is contained, and therefore, it is necessary to process the composition. The food of the present invention can be classified as a functional food because it has specific effects of improving male sexual function and relieving fatigue.

In the specific embodiment of the invention, a health care product for improving male sexual function and relieving fatigue is provided, which comprises the composition for improving male sexual function and relieving fatigue and auxiliary materials.

Wherein, the auxiliary materials refer to excipients and other additional materials used in the production of health care products. These adjuvants act as auxiliary agents in health products, such as helping to improve the appearance, mouthfeel, stability, etc. of the product, but they do not generally provide the main functional components of the health product themselves.

The health care product is in the dosage forms of tablets, capsules, granules, solid beverages or oral liquid.

Preferably, the health care product of the invention is solid beverage, and the preparation method comprises the following steps: weighing the raw materials according to the formula proportion, uniformly mixing, adding the sweetener and the sour agent, uniformly mixing, packaging, and checking.

Further preferably, the preparation method of the solid beverage comprises the following steps:

1) Weighing the raw materials according to the proportion of the formula, uniformly mixing, and adding 0.4 part of stevioside serving as a sweetener and 0.8 part of lemon juice powder serving as an acidulant.

2) After being mixed evenly, the mixture is packaged by a packaging machine, each bag is 5g, and the solid beverage for improving male sexual function and resisting fatigue is obtained after inspection.

The invention provides a composition for improving male sexual function and relieving fatigue and application thereof, wherein the composition mainly takes oyster peptide, tomato seed oil, eucommia male flowers, ginseng and wolfberry ferment, pumpkin seed oil and broccoli seed water extracts as raw materials, combines according to a certain proportion by virtue of monarch, minister, assistant and guide theory, and performs synergistic interaction on the basis of respective effects, and starts from various factors possibly causing sexual function reduction, thereby achieving the effects of improving male sexual function and relieving fatigue.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

Unless specifically indicated, the technical means used in the embodiments of the present invention are conventional means well known to those skilled in the art. Materials and reagents used in the examples of the present invention are available from regular commercial sources unless otherwise specified.

In the following examples, unless otherwise specified, the parts referred to are parts by weight.

In the following examples, the tomato seed oil content of the tomato seed oil microcapsule powder used was 10%; the pumpkin seed oil microcapsule powder has pumpkin seed oil content of 75%.

The oyster peptide has average relative molecular weight of 500Da, protein content of 95%, zinc content of 0.15% and taurine content of 1.7%.

The contents of probiotics in ginseng and wolfberry fruit in the ginseng and wolfberry fruit ferment are 13%, 7% and 2% respectively.

The content of the sulforaphane in the broccoli seed water extract is 5%, and the content of the sulforaphane is 18%.

Example 1

The embodiment provides a composition for improving male sexual function and relieving fatigue, which comprises the following raw materials in parts by weight: 10 parts of oyster peptide, 4 parts of eucommia male flowers, 5 parts of tomato seed oil microcapsule powder (which is converted into 0.5 part of pure tomato seed oil), 3 parts of pumpkin seed oil microcapsule powder (which is converted into 2.25 parts of pure pumpkin seed oil), 17 parts of ginseng and wolfberry ferment and 6 parts of broccoli seed water extract.

The embodiment also provides a solid beverage containing the composition, and the preparation method of the solid beverage comprises the following steps:

Example 2

The embodiment provides a composition for improving male sexual function and relieving fatigue, which comprises the following raw materials in parts by weight: 7 parts of oyster peptide, 2 parts of eucommia male flowers, 5 parts of tomato seed oil microcapsule powder (which is converted into 0.5 part of pure tomato seed oil), 3 parts of pumpkin seed oil microcapsule powder (which is converted into 2.25 parts of pure pumpkin seed oil), 18 parts of ginseng and wolfberry ferment and 6 parts of broccoli seed water extract.

A solid beverage for improving male sexual function and relieving fatigue was provided in the same manner as in example 1.

Example 3

The embodiment provides a composition for improving male sexual function and relieving fatigue, which comprises the following raw materials in parts by weight: 8 parts of oyster peptide, 4 parts of eucommia male flowers, 3 parts of tomato seed oil microcapsule powder (which is converted into 0.3 part of pure tomato seed oil), 3 parts of pumpkin seed oil microcapsule powder (which is converted into 2.25 parts of pure pumpkin seed oil), 18 parts of ginseng and wolfberry ferment and 8 parts of broccoli seed water extract.

Example 4

The embodiment provides a composition for improving male sexual function and relieving fatigue, which comprises the following raw materials in parts by weight: 10 parts of oyster peptide, 4 parts of eucommia male flowers, 3 parts of tomato seed oil microcapsule powder (which is converted into 0.3 part of pure tomato seed oil), 2 parts of pumpkin seed oil microcapsule powder (which is converted into 1.5 parts of pure pumpkin seed oil), 15 parts of ginseng and wolfberry ferment and 5 parts of broccoli seed water extract.

Comparative example 1

The comparative example provides a composition, which comprises the following raw material medicaments in part by weight: ginseng 0.26 parts, matrimony vine 0.13 parts, eucommia staminate flower 0.13 parts, deer collagen peptide 0.04 parts and oyster peptide 0.04 parts.

Comparative example 2

The comparative example provides a composition, which comprises the following raw material medicaments in part by weight: 150 parts of eucommia male flowers, 150 parts of cordyceps militaris, 120 parts of rhizoma polygonati, 60 parts of ginseng, 50 parts of saussurea involucrata culture and 30 parts of oyster peptides.

Comparative example 3

This comparative example provides a composition which differs from example 1 in that oyster peptide is replaced with an equivalent amount of silkworm chrysalis protein peptide.

Comparative example 4

This comparative example provides a composition which differs from example 1 in that the broccoli seed aqueous extract is replaced with an equivalent amount of cabbage powder.

Comparative example 5

This comparative example provides a composition which differs from example 1 in that ginseng and wolfberry enzymes are replaced with ginseng powder and wolfberry powder.

Comparative example 6

This comparative example provides a composition which is different from example 1 in that the eucommia male flowers are replaced with the mulberry powder in the same amount.

The compositions of comparative examples 1 to 6 were prepared into solid beverages of 5g per bag in the same manner as in example 1.

Test for improving sexual function

A. Test for improving premature ejaculation

(1) Volunteer enrollment criteria

A. men aged 18-50 years; b. has a stabilizing partner; c. the time from insertion of the penis into the vagina to ejaculation is too short or the sexual desire is poor.

(2) Treatment regimen

100 Patients meeting the above criteria were selected, and the average was divided into 10 groups of 10 persons each, and the solid beverages prepared from the compositions of examples 1 to 4 and comparative examples 1 to 6 were taken respectively. The administration method comprises taking the medicine 2 times a day, one bag each time, adding 200ml warm water, and taking for 4 weeks.

(3) Therapeutic effects

The therapeutic effect is shown in Table 1.

TABLE 1

As can be seen from the data in Table 1, examples 1-4 and comparative examples 1-6 showed a significant increase in ejaculation latency and a significant difference in front and back, P < 0.05, after administration of the solid beverage. In summary, the composition of the present invention can improve premature ejaculation and the composition of example 1 has the best effect.

B. Improving erectile dysfunction

1. Experimental objects

130 Male rats of SPF grade Wistar seeds are selected, the weight is about 230g, the male rats are adaptively kept for 1 week and then undergo castration operation, 1ml/kg of 3.5% chloral hydrate is injected into the abdominal cavity to anesthetize the rats, scrotum skin is disinfected, bilateral testes of each group of animals are removed except a blank control group, and penicillin is injected into the animals after operation in an intravenous way to prevent infection. After 1 week post-surgery, rats were randomly divided into 13 groups, a blank control group (normal group), a model group, a positive control group (model group administered undecanotestosterone), examples 1-4, and comparative examples 1-6. Examples 1-4 groups were fed with the compositions of examples 1-4 of the present invention and comparative examples 1-6 groups were fed with the compositions of comparative examples 1-6 of the present invention. When the feed amount is 4.2g/kg.bw (3 times of the recommended amount of human body), the composition samples of the examples 1-4 and the comparative examples 1-6 are respectively taken for 4.2g when the test solution is prepared, distilled water is added for dissolution and the test solution is naturally up to 200ml, the blank control group and the model group are fed with equal volumes of distilled water, and the positive control group is fed with 0.02g/kg.bw of undecanotestosterone every day. The rats to be tested were respectively subjected to intragastric administration, 1 time per day, 2ml/100g.bw, and continuous intragastric administration for 4 weeks.

2. Test method and result analysis

1) Penis erection latency determination

1H after the last gastric lavage, the experimental animal is anesthetized, and the root of the penis of the rat is moistened by using a cotton swab dipped with normal saline so as to enhance the conductivity of the animal. The stimulation electrode of the BT87-2 type electro-stimulation thrombotic instrument was placed on the root of the rat penis, and local electro-stimulation (current intensity of 4 mA) was given, and the time from the start of stimulation to penis erection (erection latency) was recorded with a stopwatch. The data are shown in Table 2.

TABLE 2

As can be seen from the data in Table 2, the model group showed significantly prolonged electrical stimulation erection latency (P < 0.01) compared to the blank group, indicating successful modeling. The examples 1-4 and comparative examples 1-6 significantly improved the excitability of the penis of the castrated rats to the external stimulus, the difference was extremely remarkable (P < 0.01), and the effect of example 1 was most remarkable, and the penile erection latency time was close to that of the positive control group.

2) Serum preparation and index detection

The abdominal cavity is injected with 1ml/kg of chloral hydrate with concentration of 3.5%, the abdominal aorta is used for taking blood, the blood is centrifugated for 15min at 3000r/min after solidification, serum is separated, and the blood is preserved at a low temperature of minus 70 ℃ for standby. Detecting NO according to the instruction of Nanjing established technology Co., ltd, and detecting serum testosterone (T) by a radioimmunoassay, wherein the data are shown in Table 3; the animals were dissected, called prepuce gland, prostate + seminal vesicle and levator ani muscle, and the index of the rat sexual organ was calculated and the data are shown in table 4.

TABLE 3 Table 3

As can be seen from Table 3, the serum testosterone level (T) and the NO content in the serum were significantly lower in the model group than in the control group (P < 0.01), indicating that the modeling was successful. Compared with the model, the composition can obviously improve the serum testosterone level (P is less than 0.01), which proves that the composition has the effect of promoting the serum testosterone secretion. The measurement result of the NO content in serum shows that the content of the serum NO in the composition is obviously increased (P is less than 0.01), and the composition is higher than that of a model group and a control group (P is less than 0.01), so that the composition has the effects of promoting the increase of the serum NO and promoting vasodilation. Of these, example 1 works best in promoting serum testosterone secretion and serum NO elevation.

TABLE 4 Table 4

After castration, the rats have reduced sex hormone secretion, and the major sexual organs of the rats are blocked in penis, levator ani, prostate and seminal vesicle gland development and the quality is reduced.

As can be seen from the data in Table 4, the index of the sex organs such as prepuce gland, prostate gland, seminal vesicle and levator ani muscle is obviously reduced (P is less than 0.01) compared with the control group, which indicates that the modeling is successful. Examples 1-4 and comparative examples 1-6 showed significantly higher indices of sex organs (P < 0.01) such as prepuce gland, prostate + seminal vesicle, levator ani muscle, etc., compared with the model group. It is demonstrated that the composition of the present invention has a remarkable effect of improving the index of rat sexual organs, and the composition of example 1 has the most remarkable effect of improving the index.

C. Fatigue relief test

1. Subjects and methods of administration

220 Healthy male mice of Kunming species were selected and weighed 17+ -1 g. The mice were randomized prior to the experiment into 3 large groups, the first of which (used only to determine the time to swim of the mice) was the control, examples 1-4, and comparative examples 1-6, each of which was 10. The second group (for collecting weight data of mice, anti-fatigue and anti-oxidation data) was a control group, examples 1-4, comparative examples 1-6, 10 each. The control and experimental groups were each gavaged 1 time per day. Examples 1-4 groups were fed 3.57g/kg.bw (equivalent to 3 times the recommended amount for humans) of the compositions of examples 1-4, and comparative examples 1-6 groups were fed 3.57g/kg.bw (equivalent to 3 times the recommended amount for humans) of the compositions of comparative examples 1-6. When the test solutions were prepared, 3.57g of each of the composition samples of examples 1 to 4 and comparative examples 1 to 6 was taken, and distilled water was added to dissolve and the mixture was allowed to reach 200ml, and the control group was fed with an equal volume of distilled water. The mice were each given a gavage, 1 time per day, 2ml/100g.bw, and 4 weeks continuously. Each group of mice was free to drink and eat during gavage feeding.

2. Determination and analysis of anti-fatigue function index

2.1 Weight bearing swimming time

After the first group last time had filled the mice with stomach for 30min, the roots of the mice were loaded with 5% weight lead wires, placed in a swimming box at 30℃with a water depth of 40cm, and the time from the start of the swimming of the mice to exhaustion (10 s after the sinking of the mice still not being able to float on the water surface) was recorded as its exhaustion swimming time with a stopwatch. The results are shown in Table 5.

TABLE 5

The weight-bearing swimming time reflects the degree of exercise fatigue, and in the experiment, the first group of mice are taken as a study object, and the weight-bearing swimming experiment is carried out after 4 weeks of continuous gastric lavage of the composition. The data in Table 5 shows that mice taking the compositions of the present invention can have longer life (P < 0.01) compared to the blank, with the example 1 group being the most effective. The mice weight-bearing swimming time data show that the composition can obviously improve the exercise endurance of the mice and has the anti-fatigue effect.

2.2 Second group of mouse Experimental data

2.2.1 Effect of the inventive compositions on mouse body weight

After 4 weeks of administration, the mice of each group were active, in a good mental state, smooth in coat, and free from any adverse reaction, and the results of the effect on the body weight of the mice of the second group are shown in Table 6. The weight difference of mice in each group from the beginning to the end of the experiment has no statistical significance (P is more than 0.05) compared with the blank control group, which shows that the composition has no obvious influence on the weight increase of the mice, and the fatigue resistance effect is not achieved by increasing the weight.

TABLE 6

2.2.2 Biochemical index detection

After the second group of mice are subjected to stomach filling for 30min at last time, the roots of the mice are loaded with lead wires with the weight of 2 percent, the mice are put into a swimming box at 30 ℃ for swimming for 30min, sweat is immediately taken out, eyesocket blood taking is carried out, centrifugation is carried out for 15 min at 3000 revolutions per minute at 4 ℃, supernatant serum is taken out, and the products are preserved at-80 ℃ for measuring the contents of blood sugar, urea nitrogen and lactic acid; the obtained mice are killed by dislocation of vertebra, and liver is immediately taken out and stored at-80deg.C for detecting liver glycogen content. The detection results are shown in Table 7.

TABLE 7

The table data show that 1) compared with a control group, the composition of the invention improves blood sugar in swimming mice to different degrees, has variability (P is less than 0.01), and shows that the composition of the invention can improve and slow down the consumption of blood sugar in the swimming process and increase the adaptability to organisms; 2) Examples 1-4, comparative examples 1-6, mice had significantly lower levels of lactic acid and serum urea nitrogen in the blood than the control (P < 0.01), demonstrating that the compositions of the invention reduced serum lactic acid production, reduced lactic acid accumulation and reduced urea nitrogen in the serum. 3) The liver glycogen content of the composition examples 1-4 and the liver glycogen content of the composition examples 1-6 are obviously higher than that of the control group (P is less than 0.01), which shows that the composition can reduce the liver glycogen consumption of mice.

The above data show that the compositions of the present invention have good anti-fatigue effects and that the group of examples 1 has the best effect.

From a combination of tables 5, 6 and 7, it can be seen that the composition of the present invention was safe and harmless to experimental mice. After the composition of the invention is fed to experimental mice, the time for loading swimming of the mice can be obviously increased, the content of serum urea nitrogen and lactic acid after exercise can be reduced, and the liver glycogen storage quantity can be increased, so that the anti-fatigue effect is achieved, wherein the anti-fatigue effect of the embodiment 1 is the best. According to the specification of the technical specification of health food inspection and evaluation (2023 edition), if more than one endurance exercise experiment (including weight-bearing swimming and pole climbing) and more than two biochemical markers (including two) are positive (blood lactic acid, serum urea nitrogen, myoglycogen/liver glycogen, etc.), the method is a judging standard with the anti-fatigue effect. Therefore, experiments prove that the composition has the effects of improving male sexual functions and relieving fatigue, and the group 1 of the embodiment has the best effect.

It should be noted that endpoints and any values of the ranges disclosed herein are not limited to the precise range or value, and that such range or value should be understood to include values approaching such range or value. For numerical ranges, one or more new numerical ranges may be found between the endpoints of each range, between the endpoint of each range and the individual point value, and between the individual point value, in combination with each other, and are to be considered as specifically disclosed herein.

In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "detailed description," or "some embodiments," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the embodiments. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A composition for improving male sexual function and relieving fatigue is characterized by comprising the following raw materials in parts by weight: 5-12 parts of oyster peptide, 1-5 parts of eucommia male flowers, 0.2-0.7 part of tomato seed oil, 0.75-3 parts of pumpkin seed oil, 10-20 parts of ginseng and wolfberry ferment and 3-9 parts of broccoli seed water extract.

2. The composition for improving male sexual function and relieving fatigue according to claim 1, wherein the bulk drug comprises, in parts by weight: 7-10 parts of oyster peptide, 2-4 parts of eucommia male flowers, 0.3-0.5 part of tomato seed oil, 1.5-2.25 parts of pumpkin seed oil, 15-18 parts of ginseng and wolfberry ferment and 5-8 parts of broccoli seed water extract.

3. The composition for improving male sexual function and relieving fatigue according to claim 1 or 2, wherein the oyster peptide has an average relative molecular weight of 400-600 Da, a protein content of 95% -99%, a zinc content of 0.1-0.2% and a taurine content of 1.5-2%.

4. The composition for improving male sexual function and relieving fatigue according to claim 1 or 2, wherein the ginseng and wolfberry ferment contains ginseng, wolfberry and probiotics, wherein the content of ginseng and wolfberry is 12-15%, 6-8% and the content of probiotics is 1-3% respectively.

5. The composition for improving male sexual function and relieving fatigue according to claim 1 or2, wherein the tomato seed oil is a raw material medicine in the form of tomato seed oil microcapsule powder;

6. The composition for improving male sexual function and relieving fatigue according to claim 1 or 2, wherein the content of sulforaphane in the broccoli seed aqueous extract is 4-7% and the content of sulforaphane is 16-20%.

7. Use of a composition for improving male sexual function and alleviating fatigue according to any of claims 1-6 for the preparation of a medicament, health product or food for improving male sexual function and/or alleviating fatigue.

8. A health product for improving male sexual function and relieving fatigue, which is characterized by comprising the composition for improving male sexual function and relieving fatigue according to any one of claims 1-6 and auxiliary materials.

9. The health product for improving male sexual function and relieving fatigue according to claim 8, wherein the dosage form of the health product is a tablet, a capsule, a solid beverage, a granule or an oral liquid.

10. The health product for improving male sexual function and relieving fatigue according to claim 9, wherein the formulation of the health product is a solid beverage, and the preparation method comprises:

weighing the raw materials according to the formula proportion, uniformly mixing, adding the sweetener and the sour agent, uniformly mixing, packaging, and checking.