CN118526617A - Control method of VHP vaporizing device and sterilizing equipment - Google Patents
Control method of VHP vaporizing device and sterilizing equipment Download PDFInfo
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- CN118526617A CN118526617A CN202411013889.7A CN202411013889A CN118526617A CN 118526617 A CN118526617 A CN 118526617A CN 202411013889 A CN202411013889 A CN 202411013889A CN 118526617 A CN118526617 A CN 118526617A
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- 230000001954 sterilising effect Effects 0.000 title claims abstract description 187
- 230000008016 vaporization Effects 0.000 title claims abstract description 110
- 238000000034 method Methods 0.000 title claims abstract description 46
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 375
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 163
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 67
- 239000007789 gas Substances 0.000 claims abstract description 54
- 239000012159 carrier gas Substances 0.000 claims abstract description 30
- 239000007788 liquid Substances 0.000 claims abstract description 30
- 239000006200 vaporizer Substances 0.000 claims description 54
- 238000001514 detection method Methods 0.000 claims description 29
- 238000009834 vaporization Methods 0.000 claims description 29
- 230000002596 correlated effect Effects 0.000 claims description 19
- 238000000354 decomposition reaction Methods 0.000 claims description 16
- 238000011084 recovery Methods 0.000 claims description 16
- 238000005259 measurement Methods 0.000 claims description 8
- 230000001276 controlling effect Effects 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 3
- 230000000875 corresponding effect Effects 0.000 claims description 2
- 238000007664 blowing Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 12
- 238000012360 testing method Methods 0.000 description 12
- 238000009833 condensation Methods 0.000 description 6
- 230000005494 condensation Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 4
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/208—Hydrogen peroxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/14—Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention provides a control method of a VHP vaporizing device and sterilizing equipment, wherein the control method comprises the following steps: the concentration of gaseous hydrogen peroxide and the concentration of gaseous water within the sterilization chamber are detected to obtain a relative saturation and/or dew point temperature within the sterilization chamber. Adjusting at least one of a plurality of setting parameters of the VHP vaporizing device according to the obtained relative saturation and/or dew point temperature in the sterilization chamber to obtain a relatively stable relative saturation output; controlling the actual temperature in the sterilization chamber according to the calculated dew point temperature in the sterilization chamber; the plurality of setting parameters of the VHP vaporizing device comprise the dosing speed of adding the hydrogen peroxide liquid to the VHP vaporizing device, the concentration of the hydrogen peroxide in the hydrogen peroxide liquid added to the VHP vaporizing device, the temperature and humidity of the carrier gas for blowing the sterilizing gas formed by the VHP vaporizing device out of the VHP vaporizing device and the carrier gas flow rate.
Description
Technical Field
The invention relates to the technical field of VHP vaporization, in particular to a control method of a VHP vaporization device and sterilization equipment.
Background
In a sterilization apparatus with VHP vaporizing means, if there is a place below the dew point temperature in the sterilization chamber, the sterilization effect will be affected; if the relative saturation in the sterilization chamber is not stable, the sterilization effect is also affected.
However, it is difficult to obtain a relatively stable relative saturation output and to control the actual temperature within the sterilization chamber with existing sterilization equipment.
Disclosure of Invention
The main purpose of the invention is to provide a control method and a sterilization device of a VHP vaporization device, so as to obtain relatively stable relative saturation output; and controlling the actual temperature in the sterilization chamber according to the obtained dew point temperature in the sterilization chamber.
In order to achieve the above object, according to one aspect of the present invention, there is provided a control method of a VHP vaporizer, an air outlet of the VHP vaporizer being adapted to communicate with a sterilization chamber to deliver a sterilization gas into the sterilization chamber, the sterilization gas comprising gaseous hydrogen peroxide and gaseous water; the control method comprises the following steps: detecting the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water in the sterilization chamber to obtain the relative saturation and/or dew point temperature in the sterilization chamber; adjusting at least one of a plurality of setting parameters of the VHP vaporizing device according to the obtained relative saturation and/or dew point temperature in the sterilization chamber; the plurality of setting parameters of the VHP vaporizing device comprise the dosing speed of adding the hydrogen peroxide liquid to the VHP vaporizing device, the hydrogen peroxide concentration in the hydrogen peroxide liquid added to the VHP vaporizing device, the temperature and humidity of the carrier gas for blowing the sterilizing gas formed by the VHP vaporizing device out of the VHP vaporizing device and the carrier gas flow rate.
Further, the dosing rate of hydrogen peroxide liquid to the VHP vaporizer is positively correlated to the relative saturation level within the sterilization chamber.
Further, the concentration of hydrogen peroxide in the hydrogen peroxide liquid added to the VHP vaporizer is positively correlated with the relative saturation level within the sterilization chamber.
Further, the temperature and humidity of the carrier gas is positively correlated with the relative saturation in the sterilization chamber.
Further, the carrier gas flow rate is inversely related to the relative saturation in the sterilization chamber.
Further, the dosing rate of the hydrogen peroxide liquid to the VHP vaporizer is positively correlated to the dew point temperature within the sterilization chamber.
Further, the hydrogen peroxide concentration in the hydrogen peroxide liquid added to the VHP vaporizer is positively correlated to the dew point temperature within the sterilization chamber.
Further, the temperature and humidity of the carrier gas is positively correlated with the dew point temperature within the sterilization chamber.
Further, the carrier gas flow rate is inversely related to the dew point temperature within the sterilization chamber.
Further, the air outlet of the VHP vaporizing device is communicated with the sterilization chamber through a connecting pipeline; the control method further comprises the following steps: and adjusting the chamber temperature of the sterilization chamber and/or the lumen temperature of the connecting pipeline according to the obtained relative saturation and/or dew point temperature of the hydrogen peroxide in the sterilization chamber.
Further, the chamber temperature of the sterilization chamber is inversely related to the relative saturation within the sterilization chamber.
Further, the lumen temperature of the connecting line is inversely related to the relative saturation in the sterilization chamber.
Further, the temperature of the chamber everywhere in the sterilization chamber is higher than the dew point temperature in the sterilization chamber.
Further, the temperature of the lumen of each part of the connecting pipeline is higher than the dew point temperature in the sterilizing chamber.
Further, the control method further includes: detecting the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water at the gas outlet of the VHP vaporizing device to obtain an actual measurement value of the concentration of the gaseous hydrogen peroxide output by the VHP vaporizing device and an actual measurement value of the concentration of the gaseous water output by the VHP vaporizing device; according to the concentration of the hydrogen peroxide liquid added into the VHP vaporizing device, calculating to obtain a theoretical value of the concentration of the gaseous hydrogen peroxide and a theoretical value of the concentration of the gaseous water which are output by the VHP vaporizing device; according to the measured value and the theoretical value of the concentration of the gaseous hydrogen peroxide and the measured value and the theoretical value of the concentration of the gaseous water, calculating to obtain the decomposition rate of the hydrogen peroxide and/or the vaporization efficiency of the hydrogen peroxide and/or the recovery rate of the hydrogen peroxide; the VHP vaporizing device is evaluated based on the calculated decomposition rate of hydrogen peroxide, and/or vaporization efficiency of hydrogen peroxide, and/or recovery rate of hydrogen peroxide.
Further, the decomposition rate of hydrogen peroxide= (measured value of gaseous water concentration-theoretical value of gaseous water concentration)/theoretical value of gaseous hydrogen peroxide concentration.
Further, the vaporization efficiency of hydrogen peroxide= (measured value of the concentration of gaseous hydrogen peroxide+decomposition value of hydrogen peroxide)/theoretical value of the concentration of gaseous hydrogen peroxide.
Further, recovery of hydrogen peroxide = measured value of gaseous hydrogen peroxide concentration/theoretical value of gaseous hydrogen peroxide concentration.
Further, the control method further includes: the VHP vaporizer was evaluated by adding hydrogen peroxide liquid to the VHP vaporizer at a plurality of different dosing rates, respectively, to obtain a hydrogen peroxide decomposition rate, a hydrogen peroxide vaporization efficiency, and a hydrogen peroxide recovery rate for each dosing rate.
Further, the air outlet of the VHP vaporizing device is communicated with the sterilization chamber through a connecting pipeline; the first end of the connecting pipeline is used for being connected with the air outlet of the VHP vaporizing device; a first detection position is arranged on the connecting pipeline; the first detection position is arranged close to the first end of the connecting pipeline; the control method further comprises the following steps: the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water in the lumen at the first detection position of the connecting pipeline are detected to obtain the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water at the air outlet of the VHP vaporizing device. Or the VHP vaporizing device is provided with an air outlet channel, and the outer port of the air outlet channel is an air outlet of the VHP vaporizing device; a second detection position close to the outer port of the air outlet channel is arranged in the air outlet channel; the control method further comprises the following steps: and detecting the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water at a second detection position in the air outlet channel to obtain the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water at the air outlet of the VHP vaporizing device.
According to another aspect of the present invention, there is provided a sterilization apparatus comprising a VHP vaporizer, a sterilization chamber, and a second gas concentration analyzer, an outlet of the VHP vaporizer being in communication with the sterilization chamber; at least part of the second gas concentration analyzer is arranged in the sterilizing chamber to detect the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water in the sterilizing chamber; the sterilization apparatus is suitable for the control method described above.
Further, the sterilization device further comprises a first gas concentration analyzer, at least part of which is arranged in the pipe cavity at the first detection position of the connecting pipeline, so as to detect the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water in the pipe cavity at the first detection position; or at least part of the first gas concentration analyzer is arranged at a second detection position in the gas outlet channel of the VHP vaporizing device so as to detect the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water in the pipe cavity at the second detection position.
By applying the technical scheme of the invention, the air outlet of the VHP vaporizing device is used for communicating with the sterilizing chamber so as to convey sterilizing gas into the sterilizing chamber, and the sterilizing gas comprises gaseous hydrogen peroxide and gaseous water. The control method comprises the following steps: the concentration of gaseous hydrogen peroxide and the concentration of gaseous water within the sterilization chamber are detected to obtain a relative saturation and/or dew point temperature within the sterilization chamber. Adjusting at least one of a plurality of setting parameters of the VHP vaporizing device according to the obtained relative saturation and/or dew point temperature in the sterilization chamber to obtain a relatively stable relative saturation output; in addition, according to the calculated dew point temperature in the sterilization chamber, the actual temperature in the sterilization chamber is controlled, so that the temperature in the sterilization chamber is prevented from being lower than the dew point temperature; the plurality of setting parameters of the VHP vaporizing device comprise the dosing speed of adding the hydrogen peroxide liquid to the VHP vaporizing device, the hydrogen peroxide concentration in the hydrogen peroxide liquid added to the VHP vaporizing device, the temperature and humidity of the carrier gas for blowing the sterilizing gas formed by the VHP vaporizing device out of the VHP vaporizing device and the carrier gas flow rate.
Drawings
The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this specification, illustrate embodiments of the application and together with the description serve to explain the application. In the drawings:
Fig. 1 shows a schematic structural view of an embodiment of a sterilization apparatus according to the present invention;
fig. 2 shows the trend of sterilization time with gaseous light peroxide concentration;
FIG. 3 shows the relative saturation and the gaseous hydrogen peroxide concentration as a function of test time;
Fig. 4 shows the relative saturation and the trend of the gaseous hydrogen peroxide concentration over the test time.
Wherein the above figures include the following reference numerals:
10. A VHP vaporization apparatus; 20. a sterilization chamber; 30. a connecting pipeline; 40. a first gas concentration analyzer; 50. a second gas concentration analyzer.
Detailed Description
It should be noted that, without conflict, the embodiments of the present application and features of the embodiments may be combined with each other. The application will be described in detail below with reference to the drawings in connection with embodiments.
It should be noted that the following detailed description is illustrative and is intended to provide further explanation of the application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present application. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.
The present invention provides a control method of a VHP vaporizer, referring to fig. 1, an air outlet of the VHP vaporizer 10 is used to communicate with a sterilization chamber 20 to deliver a sterilization gas into the sterilization chamber 20, wherein the sterilization gas includes gaseous hydrogen peroxide and gaseous water.
The control method comprises the following steps: the concentration of gaseous hydrogen peroxide and the concentration of gaseous water within sterilization chamber 20 are detected to obtain a relative saturation and/or dew point temperature within sterilization chamber 20. Adjusting at least one of a plurality of setting parameters of VHP vaporization apparatus 10 to obtain a relatively stable relative saturation output based on the resulting relative saturation and/or dew point temperature within sterilization chamber 20; in addition, according to the calculated dew point temperature in the sterilization chamber 20, the actual temperature in the sterilization chamber 20 is controlled, so that the temperature in the sterilization chamber 20 is prevented from being lower than the dew point temperature; the plurality of setting parameters of VHP vaporizer 10 include a dosing speed of adding hydrogen peroxide liquid to VHP vaporizer 10, a hydrogen peroxide concentration in the hydrogen peroxide liquid added to VHP vaporizer 10, a temperature and humidity of a carrier gas that blows sterilizing gas formed by VHP vaporizer 10 out of VHP vaporizer 10, and a carrier gas flow rate.
It should be noted that, since the sterilizing gas includes gaseous hydrogen peroxide and gaseous water, and the hydrogen peroxide and the water have similar molecular structures, both of which affect the condensation point of the air in the sterilizing chamber 20, the relative saturation degree in the sterilizing chamber 20 indicates the contents of the gaseous hydrogen peroxide and the gaseous water in the air in the sterilizing chamber 20. The dew point temperature within sterilization chamber 20 refers to the temperature at which saturation and condensation of gaseous hydrogen peroxide and gaseous water occurs.
Specifically, the dosing rate of hydrogen peroxide liquid to VHP vaporizer 10 is positively correlated with the relative saturation level within sterilization chamber 20; the concentration of hydrogen peroxide in the hydrogen peroxide liquid fed to VHP vaporizer 10 is positively correlated with the relative saturation level within sterilization chamber 20; the temperature and humidity of the carrier gas is positively correlated with the relative saturation level within sterilization chamber 20; the carrier gas flow rate is inversely related to the relative saturation within sterilization chamber 20.
Specifically, the dosing rate of hydrogen peroxide liquid to VHP vaporizer 10 is positively correlated to the dew point temperature within sterilization chamber 20; the hydrogen peroxide concentration in the hydrogen peroxide liquid fed to VHP vaporizer 10 is positively correlated to the dew point temperature within sterilization chamber 20; the temperature and humidity of the carrier gas is positively correlated with the dew point temperature within the sterilization chamber 20; the carrier gas flow rate is inversely related to the dew point temperature within sterilization chamber 20.
Specifically, the dew point temperature within sterilization chamber 20 is positively correlated to both the concentration of gaseous hydrogen peroxide and the concentration of gaseous water within sterilization chamber 20.
In this embodiment, the air outlet of the VHP vaporizer 10 is connected to the sterilization chamber 20 via a connection pipe 30; the control method further comprises the following steps: based on the obtained relative saturation and/or dew point temperature of the hydrogen peroxide within the sterilization chamber 20, the chamber temperature of the sterilization chamber 20 and/or the lumen temperature of the connecting line 30 are adjusted to avoid that the chamber temperature of the sterilization chamber 20 and the lumen temperature of the connecting line 30 are below the dew point temperature. If the lumen temperature of the connecting line 30 and the chamber temperature of the sterilization chamber 20 are lower than the dew point temperature, the gaseous hydrogen peroxide and the gaseous water will condense, so that it is necessary to ensure that the lumen temperature of the connecting line 30 and the chamber temperature of the sterilization chamber 20 are higher than the dew point temperature in the sterilization chamber 20 to avoid condensation of the system.
Specifically, the chamber temperature of sterilization chamber 20 is inversely related to the relative saturation within sterilization chamber 20. The lumen temperature of connecting line 30 is inversely related to the relative saturation within sterilization chamber 20.
Specifically, the connection pipeline 30 is subjected to heat preservation or heat tracing, so that the temperature of all the pipe cavities of the connection pipeline 30 is higher than the dew point temperature in the sterilization chamber 20, and the condensation of the gaseous hydrogen peroxide and the gaseous water in the pipe cavities of the connection pipeline 30 is avoided, so that the concentration of the gaseous hydrogen peroxide is influenced.
Optionally, when the gas outlet of the VHP vaporizer 10 communicates with the plurality of sterilization chambers 20 to deliver a sterilization gas into the plurality of sterilization chambers 20, the concentration of gaseous hydrogen peroxide and the concentration of gaseous water within at least one sterilization chamber 20 are detected to adjust at least one of the plurality of set parameters of the VHP vaporizer 10.
Further, when the air outlet of the VHP vaporizer 10 is communicated with the plurality of sterilization chambers 20, the plurality of connection pipelines 30 are provided, the plurality of connection pipelines 30 are arranged in one-to-one correspondence with the plurality of sterilization chambers 20, and the air outlet of the VHP vaporizer 10 is communicated with each sterilization chamber 20 through the corresponding connection pipeline 30.
In this embodiment, the control method further includes: detecting the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water at the gas outlet of the VHP vaporizing device 10 to obtain an actual measurement value of the concentration of the gaseous hydrogen peroxide output by the VHP vaporizing device 10 and an actual measurement value of the concentration of the gaseous water output by the VHP vaporizing device 10; calculating a theoretical value of the concentration of the gaseous hydrogen peroxide and a theoretical value of the concentration of the gaseous water which should be output by the VHP vaporizing device 10 according to the concentration of the hydrogen peroxide liquid added to the VHP vaporizing device 10; according to the measured value and the theoretical value of the concentration of the gaseous hydrogen peroxide and the measured value and the theoretical value of the concentration of the gaseous water, calculating to obtain the decomposition rate of the hydrogen peroxide and/or the vaporization efficiency of the hydrogen peroxide and/or the recovery rate of the hydrogen peroxide; the VHP vaporizing device 10 is evaluated based on the calculated hydrogen peroxide decomposition rate, and/or hydrogen peroxide vaporization efficiency, and/or hydrogen peroxide recovery rate.
Specifically, the decomposition rate of hydrogen peroxide= ((actual measured value of gaseous water concentration-theoretical value of gaseous water concentration)/theoretical value of gaseous hydrogen peroxide concentration) ×100%.
Specifically, the vaporization efficiency of hydrogen peroxide= ((measured value of the concentration of hydrogen peroxide in the gaseous state+decomposition value of hydrogen peroxide)/theoretical value of the concentration of hydrogen peroxide in the gaseous state) ×100%.
Specifically, the recovery rate of hydrogen peroxide= (actual measurement value of the concentration of gaseous hydrogen peroxide/theoretical value of the concentration of gaseous hydrogen peroxide) ×100%.
Specifically, the smaller the decomposition rate of hydrogen peroxide, the higher the vaporization efficiency of hydrogen peroxide and the higher the recovery rate of hydrogen peroxide, the better the performance of VHP vaporization apparatus 10.
In this embodiment, the control method further includes: the VHP vaporizing device 10 was evaluated by adding hydrogen peroxide liquid to the VHP vaporizing device 10 at a plurality of different dosing speeds, respectively, to obtain a decomposition rate of hydrogen peroxide, a vaporization efficiency of hydrogen peroxide, and a recovery rate of hydrogen peroxide for each dosing speed. Wherein, the dosing speed is the only variable, and the other parameters are kept unchanged.
In this embodiment, the first way to detect the concentration of gaseous hydrogen peroxide and the concentration of gaseous water at the outlet of VHP vaporizing device 10 is: a first end of the connecting line 30 is used for connecting with an air outlet of the VHP vaporizer 10; the connecting pipeline 30 is provided with a first detection position; the first detection position is arranged near the first end of the connecting pipeline 30; the control method further comprises the following steps: the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water in the lumen at the first detection position of the connecting line 30 are detected to obtain the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water at the outlet of the VHP vaporizing device 10.
In this embodiment, the second way to detect the concentration of gaseous hydrogen peroxide and the concentration of gaseous water at the outlet of VHP vaporizing device 10 is: the VHP vaporizing device 10 is provided with an air outlet channel, and the outer port of the air outlet channel is an air outlet of the VHP vaporizing device 10; a second detection position close to the outer port of the air outlet channel is arranged in the air outlet channel; the control method further comprises the following steps: the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water at the second detection position in the gas outlet channel are detected to obtain the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water at the gas outlet of the VHP vaporizing device 10.
The invention also provides a sterilization device comprising a VHP vaporizing device 10, a sterilization chamber 20 and a second gas concentration analyzer 50, wherein the gas outlet of the VHP vaporizing device 10 is communicated with the sterilization chamber 20; at least a portion of the second gas concentration analyzer 50 is disposed within the sterilization chamber 20 to detect the concentration of gaseous hydrogen peroxide and the concentration of gaseous water within the sterilization chamber 20; the sterilization device is suitable for the control method.
Optionally, the sterilization apparatus includes a plurality of sterilization chambers 20, and the air outlet of vhp vaporizer 10 is in communication with the plurality of sterilization chambers 20. At least a portion of the second gas concentration analyzer 50 is disposed within one of the sterilization chambers 20 to detect the concentration of gaseous hydrogen peroxide and the concentration of gaseous water within that sterilization chamber 20.
In this embodiment, the sterilization apparatus further includes a first gas concentration analyzer 40.
Optionally, the first gas concentration analyzer 40 is arranged in a first manner: as shown in fig. 1, at least part of the first gas concentration analyzer 40 is disposed within the lumen at the first detection location of the connecting line 30 to detect the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water within the lumen at the first detection location.
Optionally, the second arrangement of the first gas concentration analyzer 40 is: at least part of the first gas concentration analyzer 40 is disposed at a second detection location within the gas outlet channel of the VHP vaporization apparatus 10 to detect the concentration of gaseous hydrogen peroxide and the concentration of gaseous water within the lumen at the second detection location.
Alternatively, both the first gas concentration analyzer 40 and the second gas concentration analyzer 50 employ the gas concentration analyzer mentioned in patent CN106645024 a.
The following experiments are each exemplified by a sterilization chamber 20.
For example: the temperature of the lumen of each part provided with the connecting pipeline 30 is 60 degrees; the flow rate of the carrier gas is 100L/min; the carrier gas pressure is normal pressure. Enabling the VHP vaporization device to start running; after the lumen temperature of the connecting pipeline 30 and the chamber temperature of the sterilization chamber 20 are stable, respectively adding 0.5g/min to 3.6g/min of 35% H 2O2 standard solution into the VHP vaporizing device, and directly reading the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water at the gas outlet of the VHP vaporizing device, and the concentration change trend of the gaseous hydrogen peroxide and the concentration change trend of the gaseous water through the data output port of the first gas concentration analyzer 40; each dosing rate was continued for half an hour and the concentration of gaseous hydrogen peroxide and the concentration of gaseous water at the outlet of the VHP vaporizing device were recorded.
At the time of recording, the average concentration for each dosing rate over a period of 10 minutes to 20 minutes may be selected. Stabilization for 10 minutes is to ensure stability of measurement to ensure that concentration fluctuations are stable.
The specific implementation operation flow is as follows: 1. powering up for checking; 2. preheating a system; 3. adding medicine and testing; 4. recording data; 5. removing residues and purging; 6. and (5) powering off and shutting down.
Tables one to four are some experimental data. As can be seen from the combination of tables one to three, under the same test conditions, the hydrogen peroxide recovery rates of different VHP vaporizer were different, and the higher the hydrogen peroxide recovery rate, the better the hydrogen peroxide vaporization effect of the VHP vaporizer was, the less hydrogen peroxide was decomposed, and the better the performance of the VHP vaporizer was.
List one
Watch II
Watch III
Table four
From the combination of Table IV, it can be seen that VHP vaporization devices with better quality can be selected according to hydrogen peroxide recovery rate and vaporization efficiency of three different VHP vaporization devices. Meanwhile, the quality of each index of the VHP vaporizing device can be clearly and intuitively known, and the VHP vaporizing device has an important effect on performance evaluation of the VHP vaporizing device. Solves the problem that the production and use quality of the VHP vaporizing device cannot be judged at present.
The dew point temperature and the relative saturation can be accurately calculated through the concentration detection of the gaseous hydrogen peroxide and the gaseous water; under the conditions that the temperature and the pressure in the sterilization chamber 20 and the connecting pipeline 30 are constant and the flow rate of the sterilization gas is also constant, the relative saturation and the dew point temperature are constant; if the added hydrogen peroxide is supersaturated, and excessive hydrogen peroxide is added, the phenomenon of condensation of gaseous hydrogen peroxide can occur, so that the concentration of the gaseous hydrogen peroxide is rapidly reduced, and the sterilization effect cannot be improved; the optimal dosage of hydrogen peroxide can be calculated through the measured concentrations of the gaseous hydrogen peroxide and the gaseous water, so that the best sterilization effect is achieved, and the problems of low vaporization efficiency, insufficient dosing or incomplete sterilization caused by condensation phenomenon caused by excessive dosing are avoided.
For example: combining the experimental data in the fifth table, under the condition that the temperature and the pressure in the sterilizing chamber 20 and the connecting pipeline 30 are both certain, carrying the vaporized gaseous hydrogen peroxide into the sterilizing chamber 20 by carrier gas for sterilizing test; if the dosage of 35% hydrogen peroxide is 5ml/min, the dew point temperature is about 59.6 ℃ at this time, and the temperature distribution in the connecting pipeline 30 and the sterilizing chamber 20 has certain uniformity deviation, if a certain position in the scene is lower than the dew point temperature, the gaseous hydrogen peroxide is condensed in the interior, so that the sterilizing effect is affected; meanwhile, the concentration of the gaseous water is controlled, and the data can be greatly influenced; if the amount of the additive is further increased, the saturation exceeds 100%, and the sterilization effect becomes worse with the increase of the amount of the additive. Therefore, detection of the concentration of gaseous hydrogen peroxide is highly necessary.
The sterilization effect test data for different concentrations of gaseous hydrogen peroxide and different relative saturations of the sterilization chamber 20 are shown in tables five and six, and in combination with fig. 2 to 4, show that the concentrations of gaseous hydrogen peroxide are exponentially related to the sterilization time D value for the same chamber temperature and the same relative saturation; the higher the concentration of the gaseous hydrogen peroxide is, the smaller the D value is, and the better the sterilization effect is; the higher the relative saturation, the smaller the D value, and the better the sterilization effect; therefore, the method is an effective method for improving the sterilization effect by keeping high relative saturation at a certain concentration of the gaseous hydrogen peroxide.
Note that RS represents relative saturation. The horizontal axis in fig. 2 represents the concentration of gaseous hydrogen peroxide, and fig. 2 is a test performed at a chamber temperature of 25 degrees in sterilization chamber 20. The horizontal axis coordinates in fig. 3 and 4 are test time in min; the left vertical axis coordinate is relative saturation; the vertical axis coordinate on the right side is the concentration of gaseous hydrogen peroxide in ppm; 500ppm in fig. 3 and 4 is the expected value of the concentration of gaseous hydrogen peroxide, 90% rs in fig. 3 and 4 is the expected value of the relative saturation, and fig. 3 and 4 are both tests performed at a chamber temperature of 25 degrees in sterilization chamber 20. Fig. 3 is a graph showing the relative saturation and the trend of the gaseous hydrogen peroxide concentration with the test time, which are obtained from the experimental data of the same experiment. Fig. 4 is a graph showing the relative saturation and the trend of the gaseous hydrogen peroxide concentration with the test time, which are obtained from the experimental data of the same experiment. Fig. 3 and 4 are two experiments performed under the same test conditions.
It should be noted that the fitting formula of the uppermost curve in fig. 2 isAnd R 2 = 0.879285; the fit formula for the middle curve in FIG. 2 isAnd R 2 = 0.986557; the fitting formula of the lowermost curve in FIG. 2 isAnd R 2 = 0.875869.
TABLE five
TABLE six
From the above description, it can be seen that the above embodiments of the present invention achieve the following technical effects:
In the control method of the VHP vaporizer provided by the invention, the air outlet of the VHP vaporizer 10 is used for communicating with the sterilization chamber 20 to convey the sterilization gas into the sterilization chamber 20, wherein the sterilization gas comprises gaseous hydrogen peroxide and gaseous water. The control method comprises the following steps: the concentration of gaseous hydrogen peroxide and the concentration of gaseous water within sterilization chamber 20 are detected to obtain a relative saturation and/or dew point temperature within sterilization chamber 20. Adjusting at least one of a plurality of setting parameters of VHP vaporization apparatus 10 to obtain a relatively stable relative saturation output based on the resulting relative saturation and/or dew point temperature within sterilization chamber 20; in addition, according to the calculated dew point temperature in the sterilization chamber 20, the actual temperature in the sterilization chamber 20 is controlled, so that the temperature in the sterilization chamber 20 is prevented from being lower than the dew point temperature; the plurality of setting parameters of VHP vaporizer 10 include a dosing speed of adding hydrogen peroxide liquid to VHP vaporizer 10, a hydrogen peroxide concentration in the hydrogen peroxide liquid added to VHP vaporizer 10, a temperature and humidity of a carrier gas that blows sterilizing gas formed by VHP vaporizer 10 out of VHP vaporizer 10, and a carrier gas flow rate.
It should be noted that the terms "first," "second," and the like in the description and the claims of the present application and the above figures are used for distinguishing between similar objects and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used may be interchanged where appropriate such that embodiments of the application described herein may be capable of being practiced otherwise than as specifically illustrated and described. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
Spatially relative terms, such as "above … …," "above … …," "upper surface on … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial location relative to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "above" or "over" other devices or structures would then be oriented "below" or "beneath" the other devices or structures. Thus, the exemplary term "above … …" may include both orientations "above … …" and "below … …". The device may also be positioned in other different ways (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A method of controlling a VHP vaporizer, the gas outlet of the VHP vaporizer being adapted to communicate with a sterilization chamber (20) for delivering a sterilization gas into the sterilization chamber (20), the sterilization gas comprising gaseous hydrogen peroxide and gaseous water; the control method is characterized by comprising the following steps:
Detecting the concentration of gaseous hydrogen peroxide and the concentration of gaseous water within the sterilization chamber (20) to obtain a relative saturation and/or dew point temperature within the sterilization chamber (20);
Adjusting at least one of a plurality of setting parameters of said VHP vaporizing device according to the obtained relative saturation and/or dew point temperature within said sterilization chamber (20); the VHP vaporizer comprises a VHP vaporizer body, a VHP vaporizer, a carrier gas, a temperature and humidity and a carrier gas flow rate, wherein the VHP vaporizer body is provided with a plurality of setting parameters including a dosing speed of adding hydrogen peroxide liquid to the VHP vaporizer body, a hydrogen peroxide concentration in the hydrogen peroxide liquid added to the VHP vaporizer body, and a carrier gas blowing-out temperature and a carrier gas flow rate of the carrier gas of the VHP vaporizer body.
2. The method for controlling a VHP vaporizing device according to claim 1, wherein,
The dosing rate of hydrogen peroxide liquid to the VHP vaporizer is positively correlated with the relative saturation level within the sterilization chamber (20); and/or
The concentration of hydrogen peroxide in the hydrogen peroxide liquid fed to the VHP vaporizing device is positively correlated with the relative saturation level within the sterilization chamber (20); and/or
The temperature and humidity of the carrier gas is positively correlated with the relative saturation in the sterilization chamber (20); and/or
-Said carrier gas flow rate is inversely related to the relative saturation in said sterilization chamber (20); and/or
The dosing rate of hydrogen peroxide liquid to the VHP vaporizer is positively correlated with the dew point temperature within the sterilization chamber (20); and/or
The hydrogen peroxide concentration in the hydrogen peroxide liquid fed to the VHP vaporizing device is positively correlated with the dew point temperature within the sterilization chamber (20); and/or
The temperature and humidity of the carrier gas is positively correlated with the dew point temperature in the sterilization chamber (20); and/or
The carrier gas flow rate is inversely related to the dew point temperature within the sterilization chamber (20).
3. The control method of a VHP vaporizer according to claim 1, characterized in that the gas outlet of the VHP vaporizer is connected to the sterilization chamber (20) by means of a connecting line (30); the control method further includes:
Adjusting the chamber temperature of the sterilization chamber (20) and/or the lumen temperature of the connecting line (30) according to the obtained relative saturation and/or dew point temperature of the hydrogen peroxide in the sterilization chamber (20).
4. The method for controlling a VHP vaporizing device of claim 3,
-The chamber temperature of the sterilization chamber (20) is inversely related to the relative saturation within the sterilization chamber (20); and/or
The lumen temperature of the connecting line (30) is inversely related to the relative saturation in the sterilization chamber (20); and/or
-The temperature of the chambers in the sterilization chamber (20) is higher than the dew point temperature in the sterilization chamber (20); and/or
The temperature of the lumen of the connecting pipeline (30) is higher than the dew point temperature in the sterilization chamber (20).
5. The control method of a VHP vaporization apparatus according to claim 1, characterized in that the control method further comprises:
detecting the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water at the gas outlet of the VHP vaporizing device to obtain an actual measurement value of the concentration of the gaseous hydrogen peroxide output by the VHP vaporizing device and an actual measurement value of the concentration of the gaseous water output by the VHP vaporizing device;
According to the concentration of the hydrogen peroxide liquid added into the VHP vaporizing device, calculating to obtain a theoretical value of the concentration of the gaseous hydrogen peroxide and a theoretical value of the concentration of the gaseous water which are output by the VHP vaporizing device;
according to the measured value and the theoretical value of the concentration of the gaseous hydrogen peroxide and the measured value and the theoretical value of the concentration of the gaseous water, calculating to obtain the decomposition rate of the hydrogen peroxide and/or the vaporization efficiency of the hydrogen peroxide and/or the recovery rate of the hydrogen peroxide;
The VHP vaporizing device is evaluated based on the calculated decomposition rate of hydrogen peroxide, and/or vaporization efficiency of hydrogen peroxide, and/or recovery rate of hydrogen peroxide.
6. The method for controlling a VHP vaporizing device of claim 5,
Decomposition rate of hydrogen peroxide= (measured value of gaseous water concentration-theoretical value of gaseous water concentration)/theoretical value of gaseous hydrogen peroxide concentration; and/or
Vaporization efficiency of hydrogen peroxide= (measured value of gaseous hydrogen peroxide concentration+decomposition value of hydrogen peroxide)/theoretical value of gaseous hydrogen peroxide concentration; and/or
Recovery of hydrogen peroxide = measured value of gaseous hydrogen peroxide concentration/theoretical value of gaseous hydrogen peroxide concentration.
7. The control method of the VHP vaporization apparatus according to claim 5, characterized in that the control method further comprises:
And respectively adding hydrogen peroxide liquid into the VHP vaporizing device at a plurality of different dosing speeds to obtain the decomposition rate of hydrogen peroxide, the vaporization efficiency of hydrogen peroxide and the recovery rate of hydrogen peroxide corresponding to each dosing speed, so as to evaluate the VHP vaporizing device.
8. The method for controlling a VHP vaporizing device of claim 5,
The air outlet of the VHP vaporizing device is communicated with the sterilization chamber (20) through a connecting pipeline (30); the first end of the connecting pipeline (30) is used for being connected with the air outlet of the VHP vaporizing device; a first detection position is arranged on the connecting pipeline (30); the first detection position is arranged close to the first end of the connecting pipeline (30); the control method further includes: detecting the concentration of gaseous hydrogen peroxide and the concentration of gaseous water in the lumen at a first detection position of the connecting pipeline (30) to obtain the concentration of gaseous hydrogen peroxide and the concentration of gaseous water at the gas outlet of the VHP vaporizing device; or alternatively
The VHP vaporizing device is provided with an air outlet channel, and the outer port of the air outlet channel is an air outlet of the VHP vaporizing device; a second detection position close to the outer port of the air outlet channel is arranged in the air outlet channel; the control method further includes: and detecting the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water at a second detection position in the air outlet channel to obtain the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water at the air outlet of the VHP vaporizing device.
9. A sterilization apparatus characterized by comprising a VHP vaporizer, a sterilization chamber (20), and a second gas concentration analyzer (50), an outlet of the VHP vaporizer being in communication with the sterilization chamber (20); at least part of the second gas concentration analyzer (50) is disposed within the sterilization chamber (20) to detect the concentration of gaseous hydrogen peroxide and the concentration of gaseous water within the sterilization chamber (20); the sterilization apparatus is adapted for use in the control method of any one of claims 1 to 8.
10. Sterilization apparatus according to claim 9, characterized in that it further comprises a first gas concentration analyzer (40),
At least part of the first gas concentration analyzer (40) is arranged in a lumen of the connecting pipeline (30) at a first detection position so as to detect the concentration of the gaseous hydrogen peroxide and the concentration of the gaseous water in the lumen at the first detection position; or alternatively
At least part of the first gas concentration analyzer (40) is disposed at a second detection location within the outlet channel of the VHP vaporizer to detect the concentration of gaseous hydrogen peroxide and the concentration of gaseous water within the lumen at the second detection location.
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