CN118083892B - Low-temperature filling device - Google Patents
Low-temperature filling device Download PDFInfo
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- CN118083892B CN118083892B CN202410524630.2A CN202410524630A CN118083892B CN 118083892 B CN118083892 B CN 118083892B CN 202410524630 A CN202410524630 A CN 202410524630A CN 118083892 B CN118083892 B CN 118083892B
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- temperature
- bottle
- cooling
- filling
- cooling circulation
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- 238000001816 cooling Methods 0.000 claims abstract description 145
- 239000007788 liquid Substances 0.000 claims abstract description 100
- 239000003814 drug Substances 0.000 claims abstract description 81
- 238000001125 extrusion Methods 0.000 claims abstract description 18
- 238000004321 preservation Methods 0.000 claims abstract description 11
- 239000002826 coolant Substances 0.000 claims description 55
- 238000007664 blowing Methods 0.000 claims description 21
- 239000000523 sample Substances 0.000 claims description 18
- 239000000110 cooling liquid Substances 0.000 claims description 15
- 238000007789 sealing Methods 0.000 claims description 10
- 238000012544 monitoring process Methods 0.000 claims description 9
- 239000007789 gas Substances 0.000 claims description 4
- 238000009413 insulation Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 239000000112 cooling gas Substances 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 abstract description 8
- 108090000623 proteins and genes Proteins 0.000 abstract description 7
- 102000004169 proteins and genes Human genes 0.000 abstract description 7
- 239000000047 product Substances 0.000 description 8
- 238000000465 moulding Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 101100314150 Caenorhabditis elegans tank-1 gene Proteins 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000012809 cooling fluid Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
- B67C3/26—Filling-heads; Means for engaging filling-heads with bottle necks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/007—Applications of control, warning or safety devices in filling machinery
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
- B67C2003/226—Additional process steps or apparatuses related to filling with hot liquids, e.g. after-treatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
- B67C2003/227—Additional apparatus related to blow-moulding of the containers, e.g. a complete production line forming filled containers from preforms
Landscapes
- Moulds For Moulding Plastics Or The Like (AREA)
Abstract
The invention discloses a low-temperature filling device, which is applied to the technical field of filling equipment and comprises: the buffer tank is used for storing the liquid medicine and is connected with a cooling circulation pipeline of the buffer tank; the liquid medicine inlet pipeline is a heat preservation pipe and is connected with a liquid inlet of the buffer tank; the liquid medicine outlet pipeline is a heat preservation pipe and is connected with the liquid outlet of the buffer tank; the filling valve plate is communicated with the liquid medicine outlet pipeline and is connected with a cooling circulation pipeline of the filling valve plate; the filling needle is communicated with the filling valve plate and is connected with a cooling circulation pipeline of the filling needle; an extrusion die for extruding the tube blank; the forming die is used for forming the pipe blank so as to enable the filling needle to fill filling liquid into the formed bottle, and is connected with a die cooling circulation pipeline; and the output cooling profiling clamp is connected with a clamp cooling circulation pipeline and is arranged in the bottle outlet direction, and after the forming die is opened to enable the filled bottle to be output along the bottle outlet direction, the bottle is contacted with the periphery of the bottle in a fitting way so as to cool the bottle. Is suitable for filling heat-sensitive liquid such as proteins, vaccines and the like.
Description
Technical Field
The invention relates to the technical field of filling equipment, in particular to a low-temperature filling device.
Background
BFS (Blow/Fill/Seal) equipment is used as one of aseptic preparation filling equipment, and three steps of bottle making, filling and sealing are integrated into a whole by adopting a three-in-one technology, so that the BFS (Blow/Fill/Seal) equipment is widely applied in various industries.
However, the BFS device in the prior art only meets the requirements of bottle making, filling and sealing of products, because of the production specificity, for example, after the BFS device forms the bottle body by using the mold by using the parison extruded by hot melting, the filling of the liquid product needs to be performed immediately, and the temperature of the bottle body is still very high in the past, generally greater than 60 ℃, i.e. the temperature in the working process of the BFS device in the prior art is higher, therefore, the BFS device is not suitable for filling heat-sensitive liquids such as proteins, vaccines and the like, the requirement of the heat-sensitive liquids on low temperature is higher, the temperature is generally required to be lower than 30 ℃, and the temperature of the existing BFS device is far higher than the temperature tolerance limit of the heat-sensitive liquids, so that the content of effective substances is reduced after filling, even the heat-sensitive liquids are completely ineffective, and therefore, the existing BFS device cannot be used for filling the heat-sensitive liquids.
The production process of products such as proteins, vaccines and the like has high requirements on sterility, and the process characteristics are very suitable for the filling production of BFS equipment, so that if the problem of the influence of temperature on heat-sensitive medicines can be solved, the application of the BFS equipment can be expanded.
In summary, how to provide a low-temperature filling device is a problem to be solved by those skilled in the art.
Disclosure of Invention
In view of the above, the present invention aims to provide a low-temperature filling device capable of filling heat-sensitive liquids such as proteins and vaccines.
In order to achieve the above object, the present invention provides the following technical solutions:
A low temperature filling device comprising:
The buffer tank is used for storing the liquid medicine to be filled and is connected with a buffer tank cooling circulation pipeline;
the liquid medicine inlet pipeline is a heat preservation pipe and is connected with the liquid inlet of the buffer tank;
the liquid medicine outlet pipeline is a heat preservation pipe and is connected with the liquid outlet of the buffer tank;
The filling valve plate is communicated with the liquid medicine outlet pipeline and is connected with a filling valve plate cooling circulation pipeline;
The filling needle is communicated with the filling valve plate and is connected with a filling needle cooling circulation pipeline;
an extrusion die for extruding the tube blank;
The forming die is used for forming the tube blank so as to enable the filling needle to fill the liquid medicine into the formed bottle, and is connected with a die cooling circulation pipeline;
And the output cooling profiling clamp is connected with a clamp cooling circulation pipeline and is arranged in the bottle outlet direction, and after the forming die is opened to enable the filled bottle to be output along the bottle outlet direction, the bottle is contacted with the periphery of the bottle in a fitting way so as to cool the bottle.
Optionally, the mold cooling circulation line includes:
The main mold lower part cooling circulation pipeline comprises a main mold lower part cooling channel, and a first cooling medium is communicated with the part corresponding to the contact part of the bottle and the liquid medicine;
The main mold upper cooling circulation pipeline comprises a main mold upper cooling channel, a second cooling medium is introduced corresponding to the part of the bottle which is not contacted with the liquid medicine, and the temperature of the first cooling medium is lower than that of the second cooling medium;
the lower cooling circulation pipeline of the head die comprises a lower cooling channel of the head die, and a third cooling medium is introduced corresponding to the lower part of the bottle mouth of the bottle;
The upper cooling circulation pipeline of the head mould comprises an upper cooling channel of the head mould, and a fourth cooling medium is introduced corresponding to the upper part of the bottle mouth of the bottle; the temperature of the third cooling medium is higher than the temperature of the fourth cooling medium.
Optionally, the mold seal of the main mold of the molding mold is a heat insulation part.
Optionally, a jacket is arranged outside the buffer tank, and the buffer tank cooling circulation pipeline is used for introducing cooling medium into a sealing channel formed between the jacket and the buffer tank.
Optionally, the buffer tank cooling circulation pipeline, the filling valve plate cooling circulation pipeline, the filling needle cooling circulation pipeline, the mold cooling circulation pipeline and the cooling liquid outlet pipeline of the clamp cooling circulation pipeline are all provided with flow thermometers for feedback control of the temperature and flow of the corresponding cooling circulation pipeline.
Optionally, the bottle further comprises a blowing medium temperature control pipeline for cooling gas flowing through the blowing medium temperature control pipeline, wherein the gas is used for blowing the tube blank clamped by the die clamping of the forming die so as to form the bottle.
Optionally, the liquid medicine outlet pipeline is provided with a first temperature probe for monitoring the temperature of the liquid medicine in the liquid medicine outlet pipeline in real time.
Optionally, a second temperature probe is arranged in the extrusion die head and is used for detecting the actual temperature of the tube blank in the extrusion die head in real time so as to perform feedback control on the temperature of the tube blank, so that the temperature of the tube blank is at the minimum value of the allowable temperature.
Optionally, a third temperature probe is integrated at the end of the filling needle and is used for monitoring the ambient temperature in the bottle before filling, the temperature of the liquid medicine flowing in the filling needle and the temperature change of the liquid medicine before sealing after filling in real time.
Optionally, a fourth temperature probe is arranged in the forming die and is used for monitoring the temperature change of the outer wall of the bottle body before the bottle is formed, after the bottle is filled and before the forming die is opened after being cooled.
According to the low-temperature filling device provided by the invention, in the process of filling liquid medicine, the temperature of the liquid medicine in the buffer tank is controlled by adopting the buffer tank cooling circulation pipeline so as to control the temperature of the liquid medicine in the buffer tube to be at a preset low-temperature level; and the process pipelines contacted with the liquid medicine, such as a liquid medicine inlet pipeline and a liquid medicine outlet pipeline, adopt heat preservation pipes, so that the influence of the external environment temperature on the liquid medicine temperature is avoided; in addition, the liquid medicine flowing through the filling valve plate is cooled by utilizing the filling valve plate cooling circulation pipeline, so that the low-temperature level of the liquid medicine before filling is effectively controlled; the filling needle is cooled by using a filling needle cooling circulation pipeline, so that the temperature of the liquid medicine flowing through the filling needle is isolated from being influenced by the temperature of the extrusion die head; further, the mold cooling circulation pipeline cools the molded bottle so as to ensure that the temperature of the bottle body of the bottle reaches a preset low temperature level before filling; and the clamp cooling circulation pipeline is utilized to cool the output cooling profiling clamp, and meanwhile, the output cooling profiling clamp is profiled according to the shape of the bottle and is in fit contact with the periphery of the bottle, so that the contact area between the output cooling profiling clamp and the bottle is increased, and the temperature of a region, possibly contacted with liquid medicine, on a product chain is further reduced to be lower than the liquid medicine tolerance temperature.
Therefore, the low-temperature filling device keeps warm for the liquid medicine conveying pipeline, cools the buffer tank, cools the filling valve plate, cools the filling needle, cools the forming die, cools the output cooling profiling clamp, and is equivalent to carrying out temperature control treatment on all the liquid medicine filling contact flow related pipelines, containers and the like, and through a series of heat preservation and cooling measures, the accurate control on the liquid medicine temperature is realized, and the requirement of low-temperature filling is met, so that the low-temperature filling device can be suitable for the filling of heat-sensitive liquids such as proteins, vaccines and the like, and can be applied to the production of low-temperature filling products, so that the application field of the low-temperature filling device is wider.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only embodiments of the present invention, and that other drawings may be obtained according to the provided drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a low temperature filling device according to an embodiment of the present invention;
FIG. 2 is an enlarged view of a portion of FIG. 1A;
FIG. 3 is an enlarged view of a portion of B in FIG. 1;
FIG. 4 is an enlarged view of a portion of C in FIG. 1;
FIG. 5 is an enlarged view of a portion of E in FIG. 4;
fig. 6 is a partial enlarged view of D in fig. 1.
Reference numerals:
1-a buffer tank; 11-a buffer tank cooling circulation pipeline; 111-a buffer tank cooling liquid inlet pipeline; 112-buffer tank cooling liquid outlet pipe; 12-jacket; 2-a liquid medicine inlet pipeline; 3-a liquid medicine outlet pipeline; 31-a first temperature probe; 4-filling the valve plate; 41-filling a valve plate cooling circulation pipeline; 411-filling a valve plate cooling liquid inlet pipeline; 412-filling a valve plate cooling liquid outlet pipeline; 5-filling needles; 51-a filling needle cooling circulation pipeline; 511-filling needle coolant inlet pipe; 512-cooling liquid outlet pipeline of filling needle; 52-a third temperature probe; 6-an extrusion die; 61-pipe blank; 62-a second temperature probe; 7-forming a mold; 71-a mold cooling circulation line; 711-a main mold lower cooling circulation pipeline; 712-main mold upper cooling circulation line; 713-a cooling circulation line in the lower part of the head mold; 714—a head mold upper cooling circulation line; 72-sealing the mold; 73-fourth temperature probe; 8-outputting a cooling profiling clamp; 81-clamp cooling circulation line; 811-clamp cooling fluid inlet pipe; 812-clamp coolant outlet pipe; 9-flow thermometer; 10-a blowing medium temperature control pipeline; 101-blowing medium into a pipeline; 102-blowing medium out of the pipe.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The core of the invention is to provide a low-temperature filling device which can meet the filling of heat-sensitive liquids such as proteins, vaccines and the like.
Referring to fig. 1, an embodiment of the present invention provides a low temperature filling device, which includes a buffer tank 1, a liquid medicine inlet pipe 2, a liquid medicine outlet pipe 3, a filling valve plate 4, a filling needle 5, an extrusion die head 6, a forming die 7 and an output cooling profiling fixture 8, wherein the buffer tank 1 is used for storing liquid medicine to be filled, and is connected with a buffer tank cooling circulation pipe 11, a liquid inlet of the buffer tank 1 is connected with the liquid medicine inlet pipe 2, a liquid outlet of the buffer tank 1 is connected with the liquid medicine outlet pipe 3, and both the liquid medicine inlet pipe 2 and the liquid medicine outlet pipe 3 are heat preservation pipes; the other end of the liquid medicine outlet pipeline 3 is communicated with a filling valve plate 4, and the filling valve plate 4 is connected with a filling valve plate cooling circulation pipeline 41; the filling needle 5 is communicated with the filling valve plate 4 and is connected with a filling needle cooling circulation pipeline 51; the extrusion die 6 is used for extruding a tube blank 61; the forming die 7 is used for forming the tube blank 61 so that the filling needle 5 fills filling liquid into the formed bottle, and the forming die 7 is connected with a die cooling circulation pipeline 71; the output cooling profiling clamp 8 is connected with a clamp cooling circulation pipeline 81, the output cooling profiling clamp 8 is arranged in the bottle outlet direction, and after the forming die 7 is opened to enable the filled bottle to be output along the bottle outlet direction, the output cooling profiling clamp 8 is in contact with the periphery of the bottle in a fitting manner so as to cool the bottle.
That is, in the low-temperature filling device provided by the embodiment of the invention, the buffer tank cooling circulation pipeline 11 is adopted to control the temperature of the liquid medicine in the buffer tank 1 in the liquid medicine filling process so as to control the temperature of the liquid medicine in the buffer tube at a preset low-temperature level; and the flow pipelines contacted with the liquid medicine, such as the liquid medicine inlet pipeline 2 and the liquid medicine outlet pipeline 3, adopt heat preservation pipes, so as to avoid the influence of the external environment temperature on the liquid medicine temperature; in addition, the liquid medicine flowing through the filling valve plate 4 is cooled by the filling valve plate cooling circulation pipeline 41, so that the low-temperature level of the liquid medicine before filling is effectively controlled; the filling needle cooling circulation pipeline 51 is utilized to cool the filling needle 5, so that the temperature of the liquid medicine flowing through the filling needle 5 is isolated from being influenced by the temperature of the extrusion die head 6; further, the mold cooling circulation line 71 cools the molded bottle to ensure that the body temperature of the bottle reaches a predetermined low temperature level before filling; and the output cooling profiling clamp 8 is cooled by the clamp cooling circulation pipeline 81, and meanwhile, the output cooling profiling clamp 8 is profiled according to the shape of the bottle and is in contact with the periphery of the bottle, so that the contact area between the output cooling profiling clamp 8 and the bottle is increased, and the temperature of a region possibly contacted with liquid medicine on a product chain is further reduced to be lower than the liquid medicine tolerance temperature.
Therefore, the low-temperature filling device keeps warm for the liquid medicine conveying pipeline, cools the buffer tank 1, cools the filling valve plate 4, cools the filling needle 5, cools the forming die 7 and cools the output cooling profiling clamp 8, is equivalent to carrying out temperature control treatment on the whole liquid medicine filling contact flow related pipeline, container and the like, realizes accurate control on the liquid medicine temperature through a series of heat preservation cooling measures, meets the requirement of low-temperature filling, and is suitable for filling thermosensitive liquids such as proteins, vaccines and the like, so that the low-temperature filling device can be applied to the production of low-temperature filling products, and the application field of the low-temperature filling device is wider.
It will be appreciated that the buffer tank cooling circulation line 11 includes a buffer tank coolant inlet pipe 111 and a buffer tank coolant outlet pipe 112, as shown in fig. 2; the filling valve plate cooling circulation line 41 includes a filling valve plate cooling liquid inlet pipe 411 and a filling valve plate cooling liquid outlet pipe 412, as shown in fig. 3; the filling needle cooling circulation line 51 includes a filling needle cooling liquid inlet pipe 511 and a filling needle cooling liquid outlet pipe 512, as shown in fig. 3; the mold cooling circulation line 71 includes a mold cooling liquid inlet pipe and a mold cooling liquid outlet pipe; the jig cooling circulation line 81 includes a jig coolant inlet pipe 811 and a jig coolant outlet pipe 812 as shown in fig. 6.
Further, in order to enhance the cooling effect on the molding die 7 such that the temperature of the bottle before filling is at a low temperature level, referring to fig. 4 and 5, in some embodiments, the die cooling circulation line 71 includes a main die lower cooling circulation line 711, a main die upper cooling circulation line 712, a head die lower cooling circulation line 713, and a head die upper cooling circulation line 714, the main die lower cooling circulation line 711 includes a main die lower cooling passage provided to the main die of the molding die 7 corresponding to a portion of the bottle in contact with the liquid medicine, the main die lower cooling circulation line 711 being filled with the first cooling medium; the main mold upper cooling circulation line 712 includes a main mold upper cooling passage provided in the main mold of the molding mold 7, corresponding to a portion of the bottle not in contact with the liquid medicine, the main mold upper cooling circulation line 712 being fed with a second cooling medium, the temperature of the first cooling medium being lower than that of the second cooling medium; the head mold lower cooling circulation pipeline 713 comprises a head mold lower cooling channel, the head mold lower cooling channel is arranged on the head mold of the forming mold 7 and corresponds to the lower part of the bottle mouth of the bottle, and the head mold lower cooling circulation pipeline 713 is communicated with a third cooling medium; the upper cooling circulation pipeline 714 of the head mould comprises an upper cooling channel of the head mould, the upper cooling channel of the head mould is arranged on the head mould of the forming mould 7, and a fourth cooling medium is communicated with the upper cooling circulation pipeline 714 of the head mould corresponding to the upper part of the bottle mouth of the bottle; the temperature of the third cooling medium is higher than the temperature of the fourth cooling medium.
That is, compared with the prior art, the present embodiment adds a main mold upper cooling circulation line 712 and a head mold lower cooling circulation line 713 to the forming mold 7, that is, two cooling passages are provided in the main mold and the head mold, respectively, that is, the main mold is provided with a main mold lower cooling passage and a main mold upper cooling passage, and the head mold is provided with a head mold lower cooling passage and a head mold upper cooling passage, since the temperature of the first cooling medium is lower than that of the second cooling medium, that is, the main mold lower cooling passage is an ultralow temperature medium passage for controlling the wall temperature of the bottle just formed within a preset temperature of low temperature filling, for example, within 30 ℃, and the main mold upper cooling passage is a general cooling medium passage for controlling the wall temperature of the bottle which is not in contact with the medicine above a temperature capable of guaranteeing the sealing quality; likewise, the temperature of the third cooling medium is higher than that of the fourth cooling medium, namely, the lower cooling channel of the head die is a common cooling channel for ensuring the sealing quality of the bottle, and the upper cooling channel of the head die is an ultralow temperature medium channel, so that the temperature of the bottle can be quickly reduced to be within a preset temperature, for example, controlled to be within 30 ℃. That is, the mold cooling circulation line 71 in the present embodiment is provided with an ultralow temperature cooling medium passage inside the molding die 7, so that it is possible to ensure that the body temperature reaches a predetermined low temperature level before filling.
The first cooling medium, the second cooling medium, the third cooling medium, and the fourth cooling medium are not particularly limited as long as the temperature of the first cooling medium is lower than the temperature of the second cooling medium and the temperature of the third cooling medium is higher than the temperature of the fourth cooling medium. In some embodiments, the first cooling medium and the fourth cooling medium are cooling media such as ethylene glycol, so as to improve the temperature difference of heat exchange; the second cooling medium and the third cooling medium are conventional cooling medium with a certain temperature.
Further, in some embodiments, the mold seal 72 of the main mold of the forming mold 7 is an insulation. That is, the present embodiment designs the mold seal 72 of the main mold as a heat insulating part, so that the influence of the ambient temperature on the temperature of the molded bottle can be isolated, and the temperature of the bottle body can be further ensured to reach a predetermined low temperature level before filling.
In addition, to further enhance the cooling effect of the molding die 7, in some embodiments, the cooling channels of the main die and the head die are both disposed at the innermost side of the die to enhance the heat exchange efficiency of the die itself.
In addition, in order to enhance the cooling effect on the buffer tank1, as shown in fig. 2, in some embodiments, a jacket 12 is provided outside the buffer tank1, and a buffer tank cooling circulation line 11 is used to introduce a cooling medium into a sealed passage formed between the jacket and the buffer tank 1. That is, in the present embodiment, the buffer tank1 has a jacket 12 type structure, and the entire housing of the buffer tank1 is cooled by introducing a cooling medium into the jacket 12 to control the temperature of the chemical liquid in the buffer tank1 to a predetermined low temperature level.
In addition, in order to ensure the cooling effect of each cooling circulation line, as shown in fig. 1, in some embodiments, the cooling liquid outlet pipes of the buffer tank cooling circulation line 11, the filling valve plate cooling circulation line 41, the filling needle cooling circulation line 51, the mold cooling circulation line 71, and the jig cooling circulation line 81 are provided with flow thermometers 9 for feedback control of the temperature and flow rate of the corresponding cooling circulation line. That is, the temperature and flow rate of the cooling medium in the cooling liquid outlet pipe of each cooling circulation pipe are detected in real time by the flow thermometer 9, so as to perform feedback control on the temperature and flow rate of the cooling medium of each cooling circulation pipe, thereby realizing control on the temperature and flow rate of the liquid medicine in the buffer tank 1, the filling valve plate 4 and the filling needle 5, controlling the molding temperature of the bottle, controlling the temperature and flow rate of the liquid medicine after the bottle is output after filling, and ensuring that the liquid medicine is in a low-temperature state in the whole production chain.
In addition, with continued reference to fig. 1, in some embodiments, the apparatus further includes a blowing medium temperature control pipe 10, where the blowing medium temperature control pipe 10 is used to cool a gas flowing through the blowing medium temperature control pipe 10, and the gas is used to blow the tube blank 61 clamped by the forming die 7 to form a bottle. That is, the air source of the air blowing is cooled during the circulation process, and the air blowing medium temperature control pipeline 10 has a cooling function, for example, in a jacket 12 circulation mode, when the air flows through the air blowing medium temperature control pipeline 10, the air blowing medium temperature control pipeline 10 is utilized to cool the air, so that the temperature in the cavity of the bottle is as low as possible.
Further, as shown in fig. 3, in some embodiments, the blowing medium temperature control line 10 includes a blowing medium inlet line 101 and a blowing medium outlet line 102, and the blowing medium outlet line 102 is provided with a flow thermometer 9 to control the temperature of the gaseous medium within the blowing medium temperature control line 10.
In addition, as shown in fig. 2, in some embodiments, the medical fluid outlet pipe 3 is provided with a first temperature probe 31 for monitoring the temperature of the medical fluid in the medical fluid outlet pipe 3 in real time. That is, the first temperature probe 31 is utilized to feed back the temperature of the liquid medicine in the liquid medicine outlet pipe 3 in real time, so as to ensure that the temperature of the liquid medicine in the liquid medicine outlet pipe 3 meets the requirement.
In addition, as shown in fig. 3, in some embodiments, a second temperature probe 62 is provided inside the extrusion die 6 for detecting the actual temperature of the tube blank 61 inside the extrusion die 6 in real time to feedback-control the temperature of the tube blank 61 so that the temperature of the tube blank 61 is at the minimum allowable temperature. That is, in this embodiment, by providing the second temperature probe 62, the real temperature of the extruded raw pipe 61 inside the extrusion die 6 is reflected in real time, and the temperature of the raw pipe 61 exiting from the extrusion die 6 can be feedback-controlled by the real temperature, so that the temperature of the raw pipe 61 exiting from the extrusion die 6 is the minimum value of the allowable temperature, which is advantageous for reducing the heat content required to be cooled as a whole. It will be appreciated that by knowing the temperature of use of each of the different materials, the temperature of the tube blank 61 before it exits the extrusion die 6 can be controlled to a minimum allowable temperature.
In addition, as shown in fig. 5, in some embodiments, a third temperature probe 52 is integrated at the end of the filling needle 5 for monitoring in real time the ambient temperature in the bottle before filling, the temperature of the liquid medicine flowing in the filling needle 5, and the temperature change of the liquid medicine before sealing after filling. The temperature change can better monitor the operation reliability of the whole low-temperature filling device.
In addition, as shown in fig. 5, in some embodiments, a fourth temperature probe 73 is provided in the forming mold 7, for monitoring the temperature change of the outer wall of the bottle body before forming, after filling, and before opening the forming mold 7 after cooling, so as to further better monitor the operation reliability of the whole low-temperature filling device.
In addition, the bottle type bottle can be further optimized in terms of bottle type design, filling volume, wall thickness of the bottle body, material quality of the container and the like, so that low-temperature level can be guaranteed. For example, the smaller the body area above the seal, the better. The closer the filled volume is to the empty bottle, the better. Under the condition of meeting the plumpness of the bottle shape, the wall thickness of the bottle shape needs to be as thin as possible, but the wall thickness needs to be met at the same time for various products, such as the eye drop bottle shape needs to meet the requirements of flat fracture, the cap can be inserted back, and the vaccine products need to be conveniently twisted off and the syringe is convenient to take medicine. In addition, the material selected by the low-temperature filling device requires the heat content of the tube blank 61 as small as possible, that is, the low-temperature filling device should be careful to use a material which is easy to cool when selecting the material of the packing material.
It should also be noted that in this specification, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions.
In this specification, each embodiment is described in a progressive manner, and each embodiment is mainly described by a difference from other embodiments, and identical and similar parts between the embodiments are referred to each other.
The low-temperature filling device provided by the invention is described in detail above. The principles and embodiments of the present invention have been described herein with reference to specific examples, the description of which is intended only to facilitate an understanding of the method of the present invention and its core ideas. It should be noted that it will be apparent to those skilled in the art that the present invention may be modified and practiced without departing from the spirit of the present invention.
Claims (4)
1. A low temperature filling apparatus, comprising:
the buffer tank (1) is used for storing liquid medicine to be filled and is connected with a buffer tank cooling circulation pipeline (11);
the liquid medicine inlet pipeline (2) is a heat preservation pipe and is connected with the liquid inlet of the buffer tank (1);
The liquid medicine outlet pipeline (3) is a heat preservation pipe and is connected with the liquid outlet of the buffer tank (1);
The filling valve plate (4) is communicated with the liquid medicine outlet pipeline (3) and is connected with a filling valve plate cooling circulation pipeline (41);
a filling needle (5) communicated with the filling valve plate (4) and connected with a filling needle cooling circulation pipeline (51);
an extrusion die (6) for extruding a tube blank (61);
a forming die (7) for forming the tube blank (61) so that the filling needle (5) fills the liquid medicine into the formed bottle, wherein the forming die (7) is connected with a die cooling circulation pipeline (71);
Outputting a cooling profiling clamp (8), connecting a clamp cooling circulation pipeline (81), and setting the clamp cooling circulation pipeline in a bottle outputting direction, and after the forming die (7) is opened to enable the filled bottle to be output along the bottle outputting direction, enabling the bottle to be in contact with the periphery of the bottle so as to cool the bottle;
The buffer tank cooling circulation pipeline (11), the filling valve plate cooling circulation pipeline (41), the filling needle cooling circulation pipeline (51), the mold cooling circulation pipeline (71) and the cooling liquid outlet pipeline of the clamp cooling circulation pipeline (81) are all provided with flow thermometers (9) for feedback control of the temperature and flow of the corresponding cooling circulation pipeline;
the bottle forming device further comprises a blowing medium temperature control pipeline (10) for cooling gas flowing through the blowing medium temperature control pipeline (10), wherein the gas is used for blowing the tube blank (61) clamped by the die assembly of the forming die (7) so as to form the bottle;
The liquid medicine outlet pipeline (3) is provided with a first temperature probe (31) for monitoring the temperature of the liquid medicine in the liquid medicine outlet pipeline (3) in real time;
a second temperature probe (62) is arranged in the extrusion die head (6) and is used for detecting the actual temperature of the tube blank (61) in the extrusion die head (6) in real time so as to perform feedback control on the temperature of the tube blank (61) and enable the temperature of the tube blank (61) to be at the minimum value of the allowable temperature;
a third temperature probe (52) is integrated at the end part of the filling needle (5) and is used for monitoring the ambient temperature in the bottle before filling, the temperature of the liquid medicine flowing in the filling needle (5) and the temperature change of the liquid medicine before sealing after filling in real time;
A fourth temperature probe (73) is arranged in the forming die (7) and is used for monitoring the temperature change of the outer wall of the bottle body before the bottle is formed, after the bottle is filled and before the forming die (7) is cooled and then opened.
2. The cold filling device according to claim 1, wherein the mold cooling circulation line (71) comprises:
A main mold lower cooling circulation line (711) including a main mold lower cooling passage through which a first cooling medium is introduced in correspondence to a portion of the bottle in contact with the chemical liquid;
a main mold upper cooling circulation line (712) including a main mold upper cooling passage through which a second cooling medium is introduced in correspondence with a portion of the bottle not in contact with the liquid medicine, the temperature of the first cooling medium being lower than the temperature of the second cooling medium;
a cooling circulation pipeline (713) at the lower part of the head mould, which comprises a cooling channel at the lower part of the head mould and is communicated with a third cooling medium corresponding to the lower part of the bottle mouth of the bottle;
A cooling circulation pipeline (714) at the upper part of the head mould, which comprises a cooling channel at the upper part of the head mould and is communicated with a fourth cooling medium corresponding to the upper part of the bottle mouth of the bottle; the temperature of the third cooling medium is higher than the temperature of the fourth cooling medium.
3. The low-temperature filling device according to claim 1, characterized in that the mold seal (72) of the main mold of the forming mold (7) is a heat insulation.
4. The low-temperature filling device according to claim 1, wherein a jacket (12) is arranged outside the buffer tank (1), and the buffer tank cooling circulation pipeline (11) is used for introducing a cooling medium into a sealing channel formed between the jacket (12) and the buffer tank (1).
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| CN202410524630.2A CN118083892B (en) | 2024-04-29 | 2024-04-29 | Low-temperature filling device |
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| CN202410524630.2A CN118083892B (en) | 2024-04-29 | 2024-04-29 | Low-temperature filling device |
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| CN118083892B true CN118083892B (en) | 2024-06-21 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE8815682U1 (en) * | 1988-12-17 | 1990-04-12 | Holstein Und Kappert Ag, 4600 Dortmund | Filling machine for filling liquids into containers |
| CN117509507A (en) * | 2022-07-29 | 2024-02-06 | 楚天科技股份有限公司 | Blowing, filling and sealing integrated machine and operation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8460733B2 (en) * | 2005-05-06 | 2013-06-11 | The Quaker Oats Company | Hot-fill beverage production with flavor injection |
| US7708035B2 (en) * | 2005-11-21 | 2010-05-04 | David Mitchell Windmiller | Bottom fillable bottles and systems for charging the same |
| CN201692146U (en) * | 2010-07-05 | 2011-01-05 | 西安好博士医疗科技有限公司 | Disposable body-cavity thermal-cold circulating pipeline |
| CN114413364B (en) * | 2022-01-25 | 2022-11-22 | 大连理工大学 | Internal circulation type clathrate hydrate cold accumulation system and method |
| CN220723564U (en) * | 2023-09-13 | 2024-04-05 | 内蒙古伊利实业集团股份有限公司 | Sterile canning system for preparing heat-sensitive materials |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE8815682U1 (en) * | 1988-12-17 | 1990-04-12 | Holstein Und Kappert Ag, 4600 Dortmund | Filling machine for filling liquids into containers |
| CN117509507A (en) * | 2022-07-29 | 2024-02-06 | 楚天科技股份有限公司 | Blowing, filling and sealing integrated machine and operation method thereof |
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