CN117882736A - Compound disinfectant and preparation method thereof - Google Patents
Compound disinfectant and preparation method thereof Download PDFInfo
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- CN117882736A CN117882736A CN202311678840.9A CN202311678840A CN117882736A CN 117882736 A CN117882736 A CN 117882736A CN 202311678840 A CN202311678840 A CN 202311678840A CN 117882736 A CN117882736 A CN 117882736A
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- compound disinfectant
- antifungal agent
- quaternary ammonium
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- ammonium salt
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 60
- 150000001875 compounds Chemical class 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 229940121375 antifungal agent Drugs 0.000 claims abstract description 42
- 239000003429 antifungal agent Substances 0.000 claims abstract description 41
- 229920001661 Chitosan Polymers 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 32
- 239000002105 nanoparticle Substances 0.000 claims abstract description 31
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 11
- 239000011833 salt mixture Substances 0.000 claims abstract description 11
- 239000003906 humectant Substances 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 60
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 37
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 35
- 239000004408 titanium dioxide Substances 0.000 claims description 30
- 238000003756 stirring Methods 0.000 claims description 26
- YUWBVKYVJWNVLE-UHFFFAOYSA-N [N].[P] Chemical compound [N].[P] YUWBVKYVJWNVLE-UHFFFAOYSA-N 0.000 claims description 24
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 14
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 claims description 14
- 239000011259 mixed solution Substances 0.000 claims description 14
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical group CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 claims description 13
- 229940073499 decyl glucoside Drugs 0.000 claims description 13
- SCXCDVTWABNWLW-UHFFFAOYSA-M decyl-dimethyl-octylazanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCC SCXCDVTWABNWLW-UHFFFAOYSA-M 0.000 claims description 13
- 235000011187 glycerol Nutrition 0.000 claims description 13
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 12
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical group C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims description 12
- 229960004884 fluconazole Drugs 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 10
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 claims description 10
- 238000001354 calcination Methods 0.000 claims description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 5
- 235000010299 hexamethylene tetramine Nutrition 0.000 claims description 5
- 239000004312 hexamethylene tetramine Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 3
- JMHWNJGXUIJPKG-UHFFFAOYSA-N CC(=O)O[SiH](CC=C)OC(C)=O Chemical compound CC(=O)O[SiH](CC=C)OC(C)=O JMHWNJGXUIJPKG-UHFFFAOYSA-N 0.000 claims description 2
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims description 2
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 21
- 230000001954 sterilising effect Effects 0.000 abstract description 16
- 230000000694 effects Effects 0.000 abstract description 11
- 230000007797 corrosion Effects 0.000 abstract description 7
- 238000005260 corrosion Methods 0.000 abstract description 7
- 241000222122 Candida albicans Species 0.000 abstract description 4
- 241000588724 Escherichia coli Species 0.000 abstract description 4
- 241000282414 Homo sapiens Species 0.000 abstract description 4
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 4
- 229940095731 candida albicans Drugs 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 abstract description 4
- 239000006260 foam Substances 0.000 abstract description 3
- 230000007794 irritation Effects 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 description 10
- 238000001035 drying Methods 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 244000005700 microbiome Species 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- -1 compound quaternary ammonium salt Chemical class 0.000 description 6
- 230000000249 desinfective effect Effects 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- YHWCPXVTRSHPNY-UHFFFAOYSA-N butan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCC[O-].CCCC[O-].CCCC[O-].CCCC[O-] YHWCPXVTRSHPNY-UHFFFAOYSA-N 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 4
- 229910000975 Carbon steel Inorganic materials 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 239000010962 carbon steel Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000001699 photocatalysis Effects 0.000 description 3
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 230000003641 microbiacidal effect Effects 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical class [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229920002413 Polyhexanide Polymers 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 238000007146 photocatalysis Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- JMXKSZRRTHPKDL-UHFFFAOYSA-N titanium ethoxide Chemical compound [Ti+4].CC[O-].CC[O-].CC[O-].CC[O-] JMXKSZRRTHPKDL-UHFFFAOYSA-N 0.000 description 1
- VXUYXOFXAQZZMF-UHFFFAOYSA-N titanium(IV) isopropoxide Chemical compound CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C VXUYXOFXAQZZMF-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Inorganic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a compound disinfectant and a preparation method thereof, wherein the compound disinfectant comprises the following raw materials in percentage by mass: 0.1-0.5% of quaternary ammonium salt mixture, 0.02-0.05% of nonionic surfactant, 0.02-0.05% of antifungal agent and chitosan modified nano particles, 0.1-0.3% of humectant and the balance of water. The quaternary ammonium salt mixture in the compound disinfectant system has good sterilization performance, the antifungal agent and the chitosan modified nano particles can reduce the foam influence and improve the sterilization activity, and the presence of the nonionic surfactant enables the sterilization to be faster and the quaternary ammonium salt mixture to be more stable. The compound disinfection liquid can kill escherichia coli, staphylococcus aureus and candida albicans, has small irritation and corrosion, and is suitable for the surface disinfection of common objects such as human body contact and the disinfection of public places.
Description
Technical Field
The invention relates to the technical field of disinfectant, in particular to a compound disinfectant and a preparation method thereof.
Background
Disinfection is a treatment method for eliminating pathogenic microorganisms in various external environments based on physical, chemical or biological means and controlling other microorganisms causing economic loss so as to achieve harmlessness, and medicines with disinfection effect are called disinfectants. With the increasing of the resistance of microorganisms to the existing disinfection products and the increasing of the knowledge of human beings on health and environmental protection, the development of a new type of high-efficiency low-toxicity disinfectant is more and more in line with the current trend.
At present, the widely used disinfectant comprises chlorine disinfectant, alcohol disinfectant, peroxide disinfectant, aldehyde disinfectant, quaternary ammonium salt disinfectant, iodine disinfectant, phenol disinfectant and guanidine disinfectant. Among them, quaternary ammonium salts and guanidine disinfectant have low corrosiveness to metals, low toxic and side effects and low influence on ecological environment, and have attracted extensive attention. Some prior art also provides compound quaternary ammonium disinfectant with better performance, for example, CN113383775A discloses a compound quaternary ammonium salt low-temperature disinfectant, and the mixture of single-chain quaternary ammonium salt, double-chain quaternary ammonium salt and heterocyclic quaternary ammonium salt is used to greatly improve the antibacterial effect. CN112088879a discloses a quaternary ammonium salt compound disinfectant, which comprises the following components: 0.1% of benzalkonium chloride, 0.02% of polyhexamethylene biguanide, 0.2% of coconut fatty acid diethanolamide, 0.2% of glycerol and the balance of deionized water, and the quaternary ammonium salt compound disinfectant has the advantages of easily purchased raw materials, easy preparation process, low production cost, no corrosion to the surfaces of people and objects, no odor, no toxicity, environmental protection and convenient use.
The existing compound quaternary ammonium salt disinfectant is mainly prepared by compounding quaternary ammonium salt or other sterilizing components to improve sterilizing performance, some nano materials are low-toxic or nontoxic and have better sterilizing performance, and the compound disinfectant with excellent performance is expected to be prepared by compounding the quaternary ammonium salt and the nano materials with sterilizing performance.
Disclosure of Invention
In order to solve the technical problems in the prior art, the invention provides a compound disinfectant, which comprises the following raw materials in percentage by mass:
0.1-0.5% of quaternary ammonium salt mixture, 0.02-0.05% of nonionic surfactant, 0.02-0.05% of antifungal agent and chitosan modified nano particles, 0.1-0.3% of humectant and the balance of water.
The disinfectant mainly comprises quaternary ammonium salt bactericides and other assistants. Typically the quaternary ammonium salt itself is not just a biocide, but is also a surfactant quaternary ammonium salt. The sterilization mechanism of the quaternary ammonium salt is as follows: the water is hydrolyzed and then is positively charged, and the water is adsorbed on the surface of microorganisms to form ionic micro-groups which gradually permeate into lipid layers and protein layers of cytoplasm, so that the permeability of cell membranes is changed, cell contents are extravasated to cause cell death, and meanwhile, cell proteins are coagulated to denature enzymes and structural proteins thereof, so that metabolism of the microorganisms and plasma proteins and cell membranes are damaged and the microorganisms are killed. The quaternary ammonium salt bactericide can effectively sterilize at low concentration, has extremely low toxicity, is safe, colorless, odorless, nonirritating and stable, and is an ideal bactericide. The nonionic surfactant in the system has no loss effect on the quaternary ammonium salt, and the nonionic surfactant can effectively reduce the surface tension, so that the quaternary ammonium salt can be more quickly and uniformly distributed on the surface of a contact object, and the sterilization performance of the quaternary ammonium salt is enhanced. The antifungal agent and the chitosan modified nano particles are provided with antifungal components, the surfactant has certain foamability, the non-uniformity of the edges of the nano particles can be helpful for defoaming, and the sterilization and disinfection performance of the compound disinfectant can be further enhanced. The existence of the humectant can reduce the influence when the compound disinfectant is applied to human bodies or other animals.
Further, the preparation method of the antifungal agent and chitosan modified nanoparticle comprises the following steps of, in parts by mass,
mixing 0.1-0.5 part of antifungal agent, 2-5 parts of nitrogen-phosphorus co-doped titanium dioxide and 100-200 parts of ethanol under stirring to obtain antifungal agent modified nitrogen-phosphorus co-doped titanium dioxide;
and mixing 2-5 parts of antifungal agent modified nitrogen-phosphorus co-doped titanium dioxide, 0.5-1 part of carboxymethyl chitosan and 100-200 parts of water by stirring to obtain the antifungal agent and chitosan modified nano particles.
Titanium dioxide has good antimicrobial properties and has been shown to kill a wide variety of bacteria, fungi and viruses. This is because titanium dioxide has a high specific surface area and a strong physical adsorption capacity, and can be effectively adsorbed and fixed on the surface of microorganisms, thereby achieving the aim of killing. The nitrogen-phosphorus co-doped titanium dioxide can effectively promote the reaction sites on the surface so as to promote the antibacterial performance. However, titanium dioxide can also show good photocatalytic performance in the presence of ultraviolet light, and the generated superoxide radical has strong oxidizing property, and has strong sterilization effect, but based on application scenes, the photocatalytic sterilization is extremely unstable, and can cause decomposition of antifungal agents and quaternary ammonium salts, so that certain side effects are brought.
Carboxymethyl chitosan is an important water-soluble chitosan derivative, has antibacterial and anti-infection properties, and also has good biocompatibility and biodegradability. The carboxymethyl chitosan is used for carrying out surface modification on the nitrogen-phosphorus co-doped titanium dioxide, so that the decomposition effect of the nitrogen-phosphorus co-doped titanium dioxide on the antifungal agent can be reduced.
Further, the stirring and mixing are continued for 5-10 hours at 500-1000 rpm.
Further, the antifungal agent is fluconazole.
Fluconazole is an antifungal drug for the treatment of deep and superficial fungal diseases in various tissues. Compared with other antifungal medicines, fluconazole has the advantage of small side effects.
Further, the preparation method of the nitrogen-phosphorus co-doped titanium dioxide comprises the following steps of, by mass,
5-10 parts of titanate, 0.5-1 part of hexamethylenetetramine, 0.2-0.5 part of phosphoric acid, 20-30 parts of water and 70-80 parts of ethanol are stirred and mixed to obtain gel, and the gel is calcined to obtain the nitrogen-phosphorus co-doped titanium dioxide.
The titanate of the present invention is not limited to a specific one, and may be at least one of ethyl titanate, n-propyl titanate, isopropyl titanate, and tetrabutyl titanate.
Further, the calcination is maintained at 300-400 ℃ for 1-2 hours.
Further, the quaternary ammonium salt mixture comprises at least one of didecyl dimethyl ammonium chloride, dioctyl dimethyl ammonium chloride, octyl decyl dimethyl ammonium chloride and benzalkonium chloride.
Further, the nonionic surfactant is decyl glucoside.
Further, the humectant is glycerin.
The invention also provides a preparation method of the compound disinfectant, which is characterized by comprising the following steps of,
mixing water, nonionic surfactant, antifungal agent, chitosan modified nano-particles and humectant to obtain a mixed solution;
and adding the quaternary ammonium salt mixture into the mixed solution, and stirring and mixing to obtain the compound disinfectant.
Compared with the prior art, the invention has the following beneficial effects:
the quaternary ammonium salt mixture in the compound disinfectant system has good sterilization performance, the antifungal agent and the chitosan modified nano particles can reduce the foam influence and improve the sterilization activity, and the presence of the nonionic surfactant enables the sterilization to be faster and the quaternary ammonium salt mixture to be more stable. The compound disinfection liquid can kill escherichia coli, staphylococcus aureus and candida albicans, has small irritation and corrosion, and is suitable for the surface disinfection of common objects such as human body contact and the disinfection of public places.
Detailed Description
The endpoints of the ranges and any values disclosed in the present invention are not limited to the precise range or value, and the range or value should be understood to include values close to the range or value. For numerical ranges, one or more new numerical ranges may be obtained in combination with each other between the endpoints of each range, between the endpoint of each range and the individual point value, and between the individual point values, and are to be considered as specifically disclosed in the present invention.
Some raw materials used in the embodiments of the present invention are described:
octyl decyl dimethyl ammonium chloride, model CY-D2, available from Shandong Chang Yao New Material Co., ltd;
benzalkonium chloride, model LA-6Q, available from shandong new materials technologies limited;
decyl glucoside, model ZH54549-25-6, available from neutralization chemistry (Shandong) Co., ltd;
fluconazole, cat No. DF0057, purchased from chengdoumeitian medical science and technology limited;
carboxymethyl chitosan, model C-87, available from Qingdao Bozhi Hui biological technology Co., ltd.
Other raw materials not mentioned are common raw materials, the above is only to help illustrate the present invention, and should not be construed as a strict limitation of the present invention, and those skilled in the art can directly purchase or prepare the same/similar raw materials by themselves.
The following description of the embodiments of the present invention will clearly and fully describe the technical solutions of the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
A preparation method of the compound disinfectant comprises the following steps:
s1, weighing 0.1% of octyl decyl dimethyl ammonium chloride, 0.2% of benzalkonium chloride, 0.03% of decyl glucoside, 0.02% of antifungal agent and chitosan modified nano particles, 0.2% of glycerol and the balance of water according to the mass percentage of the product;
s2, stirring water, decyl glucoside, an antifungal agent, chitosan modified nano particles and glycerol at 300rpm for 30min to obtain a mixed solution;
s3, adding octyl decyl dimethyl ammonium chloride and benzalkonium chloride into the mixed solution, and stirring at 500rpm for 30min to obtain the compound disinfectant.
Wherein, the preparation method of the antifungal agent and chitosan modified nano-particles comprises the following steps of,
t1, stirring 6g of tetrabutyl titanate, 1g of hexamethylenetetramine, 0.5g of phosphoric acid (mass fraction is 85%), 20g of water and 80g of ethanol at 650rpm for 6 hours to obtain gel, drying the gel in a constant-temperature oven at 120 ℃ for 12 hours, and then transferring the gel to a muffle furnace at 350 ℃ for calcining for 1 hour in an air atmosphere to obtain nitrogen-phosphorus co-doped titanium dioxide;
t2, stirring 0.3g of fluconazole and 5g of nitrogen-phosphorus co-doped titanium dioxide 200g of ethanol at 800rpm for 6 hours, then filtering and collecting insoluble substances, washing three times with water and ethanol respectively, and drying in a constant temperature oven at 80 ℃ for 12 hours to obtain the antifungal agent modified nitrogen-phosphorus co-doped titanium dioxide;
and T3, mixing 5g of antifungal agent modified nitrogen-phosphorus co-doped titanium dioxide, 1g of carboxymethyl chitosan and 200g of water at 500rpm for 5 hours, filtering and collecting insoluble substances, washing three times with water and ethanol respectively, and drying in a constant-temperature oven at 80 ℃ for 12 hours to obtain the antifungal agent and chitosan modified nano particles.
Example 2 to example 6
Referring to the formulation components in table 1 and the preparation method of example 1, the compound disinfectant of examples 2 to 6 was prepared.
Table 1 formulation components
Comparative example 1
A preparation method of the compound disinfectant comprises the following steps:
s1, weighing 0.1% of octyl decyl dimethyl ammonium chloride, 0.2% of benzalkonium chloride, 0.03% of decyl glucoside, 0.03% of chitosan modified nano particles, 0.2% of glycerol and the balance of water according to the mass percentage of the product;
s2, stirring water, decyl glucoside, chitosan modified nano particles and glycerol at 300rpm for 30min to obtain a mixed solution;
s3, adding octyl decyl dimethyl ammonium chloride and benzalkonium chloride into the mixed solution, and stirring at 500rpm for 30min to obtain the compound disinfectant.
Wherein the preparation method of the chitosan modified nano-particles comprises the following steps of,
t1, stirring 6g of tetrabutyl titanate, 1g of hexamethylenetetramine, 0.5g of phosphoric acid (mass fraction is 85%), 20g of water and 80g of ethanol at 650rpm for 6 hours to obtain gel, drying the gel in a constant-temperature oven at 120 ℃ for 12 hours, and then transferring the gel to a muffle furnace at 350 ℃ for calcining for 1 hour in an air atmosphere to obtain nitrogen-phosphorus co-doped titanium dioxide;
t2, 5g of nitrogen-phosphorus co-doped titanium dioxide, 1g of carboxymethyl chitosan and 200g of water are stirred at 800rpm for 6 hours, insoluble substances are collected by filtration, washed three times by water and ethanol respectively, and dried in a constant temperature oven at 80 ℃ for 12 hours, so that chitosan modified nano particles are obtained.
Comparative example 2
A preparation method of the compound disinfectant comprises the following steps:
s1, weighing 0.1% of octyl decyl dimethyl ammonium chloride, 0.2% of benzalkonium chloride, 0.03% of decyl glucoside, 0.03% of antifungal agent modified nano particles, 0.2% of glycerol and the balance of water according to the mass percentage of the product;
s2, stirring water, decyl glucoside, antifungal agent modified nano particles and glycerol at 300rpm for 30min to obtain a mixed solution;
s3, adding octyl decyl dimethyl ammonium chloride and benzalkonium chloride into the mixed solution, and stirring at 500rpm for 30min to obtain the compound disinfectant.
Wherein, the preparation method of the antifungal agent modified nano-particles comprises the following steps of,
t1, stirring 6g of tetrabutyl titanate, 1g of hexamethylenetetramine, 0.5g of phosphoric acid (mass fraction is 85%), 20g of water and 80g of ethanol at 650rpm for 6 hours to obtain gel, drying the gel in a constant-temperature oven at 120 ℃ for 12 hours, and then transferring the gel to a muffle furnace at 350 ℃ for calcining for 1 hour in an air atmosphere to obtain nitrogen-phosphorus co-doped titanium dioxide;
and T2, stirring 0.3g of fluconazole, 5g of nitrogen-phosphorus co-doped titanium dioxide and 200g of ethanol at 800rpm for 6 hours, filtering and collecting insoluble substances, washing three times with water and ethanol respectively, and drying in a constant temperature oven at 80 ℃ for 12 hours to obtain the antifungal agent modified nano-particles.
Comparative example 3
A preparation method of the compound disinfectant comprises the following steps:
s1, weighing 0.1% of octyl decyl dimethyl ammonium chloride, 0.2% of benzalkonium chloride, 0.03% of decyl glucoside, 0.03% of antifungal agent and chitosan modified nano particles, 0.2% of glycerol and the balance of water according to the mass percentage of the product;
s2, stirring water, decyl glucoside, an antifungal agent, chitosan modified nano particles and glycerol at 300rpm for 30min to obtain a mixed solution;
s3, adding octyl decyl dimethyl ammonium chloride and benzalkonium chloride into the mixed solution, and stirring at 500rpm for 30min to obtain the compound disinfectant.
Wherein, the preparation method of the antifungal agent and chitosan modified nano-particles comprises the following steps of,
t1, stirring 6g of tetrabutyl titanate, 20g of water and 80g of ethanol at 650rpm for 6 hours to obtain gel, drying the gel in a constant temperature oven at 120 ℃ for 12 hours, and then transferring to a muffle furnace at 350 ℃ for calcining for 1 hour in an air atmosphere to obtain titanium dioxide;
t2, stirring 0.3g of fluconazole, 5g of titanium dioxide and 200g of ethanol at 800rpm for 6 hours, then filtering and collecting insoluble matters, washing with water and ethanol for three times respectively, and drying in a constant temperature oven at 80 ℃ for 12 hours to obtain antifungal agent modified titanium dioxide;
and T3, stirring 5g of antifungal agent modified titanium dioxide, 1g of carboxymethyl chitosan and 200g of water at 500rpm for 5 hours, filtering and collecting insoluble substances, washing three times with water and ethanol respectively, and drying in a constant-temperature oven at 80 ℃ for 12 hours to obtain the antifungal agent and chitosan modified nano particles.
Comparative example 4
A preparation method of the compound disinfectant comprises the following steps:
s1, weighing 0.02% of fluconazole, 0.01% of carboxymethyl chitosan, 0.1% of octyl decyl dimethyl ammonium chloride, 0.2% of benzalkonium chloride, 0.03% of decyl glucoside, 0.2% of glycerol and the balance of water according to the mass percentage of the product;
s2, stirring carboxymethyl chitosan, water, decyl glucoside and glycerol for 30min at 300rpm to obtain a mixed solution;
s3, adding octyl decyl dimethyl ammonium chloride, benzalkonium chloride and fluconazole into the mixed solution, and stirring at 500rpm for 30min to obtain the compound disinfectant.
Test case
The sterilizing solutions of the examples and comparative examples were subjected to a microbiocidal test and a skin irritation test by referring to the quantitative method of suspensions in the national standard GB 15979-2002 hygienic Standard for Disposable sanitary articles. The results of the microbial killing test are shown in Table 2.
TABLE 2 results of microbiocidal test
From the test results in table 2, it can be seen that the invention has more excellent disinfection effect in examples 1-4, can effectively disinfect in a shorter time, the comparative examples 1 and 2 have a killing logarithmic value of >5.0 for escherichia coli, staphylococcus aureus and candida albicans after 150s, and the quaternary ammonium salt disinfecting components in examples 1-4 and comparative examples 1-2 are the same, which indicates that the quaternary ammonium salt disinfecting components selected in the invention have better disinfecting performance, meanwhile, the antifungal agent and chitosan modified nano particles enhance the disinfecting effect, the fluconazole and carboxymethyl chitosan are modified on the surface of nitrogen-phosphorus co-doped titanium dioxide, the dispersion stability is improved, the foam influence of the disinfecting liquid is reduced, and the nitrogen-phosphorus co-doped titanium dioxide can also effectively adsorb and fix on the surface of microorganisms, so that the disinfecting liquid has faster generating effect. Wherein example 2 has a killing log value of >5.0 for escherichia coli, staphylococcus aureus and candida albicans only at 30s, which is probably due to the fact that the larger ratio of antifungal agent to chitosan modified nano particles produces partial agglomeration, and the sterilizing effect is reduced.
Skin irritation tests show that the compound disinfectant prepared by the embodiment and the comparative example has no irritation to the skin.
The retention of quaternary ammonium salt was tested after 12 months of equivalent storage time according to the storage conditions in the accelerated test in GB/T38499-2020 method for evaluation of disinfectant stability, and the results are shown in Table 3.
TABLE 3 retention of quaternary ammonium salts
From the test results in table 3, the retention rate of the quaternary ammonium salt in the disinfectant of the embodiment 2 of the present invention is as high as 93.5%, which indicates that the use of fluconazole and carboxymethyl chitosan to modify nitrogen-phosphorus co-doped titanium dioxide can effectively inhibit the degradation of the quaternary ammonium salt by the titanium dioxide under the potential photocatalysis.
The corrosion performance of the compound disinfectant on carbon steel was also tested with reference to the national standard GB/T38498-2020 method for evaluating corrosiveness of disinfectant metals, and the results are shown in Table 4, wherein the corrosion rate R <0.0100mm/a is considered to be substantially non-corrosive.
TABLE 4 corrosion performance results for carbon steel
From the test results of Table 4, it can be seen that the disinfectant of example 2 of the present invention has a minimum corrosion rate to carbon steel.
Finally, it should be noted that: the foregoing description is only illustrative of the preferred embodiments of the present invention, and although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements or changes may be made without departing from the spirit and principles of the present invention.
Claims (10)
1. The compound disinfectant is characterized by comprising the following raw materials in percentage by mass:
0.1-0.5% of quaternary ammonium salt mixture, 0.02-0.05% of nonionic surfactant, 0.02-0.05% of antifungal agent and chitosan modified nano particles, 0.1-0.3% of humectant and the balance of water.
2. The compound disinfectant as set forth in claim 1, wherein the preparation method of the antifungal agent and the chitosan-modified nanoparticle comprises the following steps in parts by mass,
mixing 0.1-0.5 part of antifungal agent, 2-5 parts of nitrogen-phosphorus co-doped titanium dioxide and 100-200 parts of ethanol under stirring to obtain antifungal agent modified nitrogen-phosphorus co-doped titanium dioxide;
and mixing 2-5 parts of antifungal agent modified nitrogen-phosphorus co-doped titanium dioxide, 0.5-1 part of carboxymethyl chitosan and 100-200 parts of water by stirring to obtain the antifungal agent and chitosan modified nano particles.
3. The compound disinfectant according to claim 2, wherein the stirring and mixing are continued for 5-10 hours at 500-1000 rpm.
4. The compound disinfectant as set forth in claim 2, wherein the antifungal agent is fluconazole.
5. The compound disinfectant as set forth in claim 2, wherein the preparation method of the nitrogen-phosphorus co-doped titanium dioxide comprises the following steps in parts by mass,
5-10 parts of titanate, 0.5-1 part of hexamethylenetetramine, 0.2-0.5 part of phosphoric acid, 20-30 parts of water and 70-80 parts of ethanol are stirred and mixed to obtain gel, and the gel is calcined to obtain the nitrogen-phosphorus co-doped titanium dioxide.
6. The compound disinfectant as set forth in claim 5, wherein the calcination is maintained at 300-400 ℃ for 1-2 hours.
7. The compound disinfectant as set forth in claim 1, wherein the quaternary ammonium salt mixture includes at least one of didecyldimethyl ammonium chloride, dioctyl dimethyl ammonium chloride, octyldecyl dimethyl ammonium chloride, and benzalkonium chloride.
8. The compound disinfectant as set forth in claim 1, wherein the nonionic surfactant is decyl glucoside.
9. The compound disinfectant as set forth in claim 1, wherein the humectant is glycerin.
10. A method for preparing the compound disinfectant as set forth in any one of claims 1 to 9, which is characterized by comprising the steps of,
mixing water, nonionic surfactant, antifungal agent, chitosan modified nano-particles and humectant to obtain a mixed solution;
and adding the quaternary ammonium salt mixture into the mixed solution, and stirring and mixing to obtain the compound disinfectant.
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