CN117717325A

CN117717325A - Left ventricle pressure determining system and method based on ventricular catheter pump

Info

Publication number: CN117717325A
Application number: CN202410180984.XA
Authority: CN
Inventors: 葛柳婷; 洪锦
Original assignee: Anhui Tongling Bionic Technology Co Ltd
Current assignee: Anhui Tongling Bionic Technology Co Ltd
Priority date: 2024-02-18
Filing date: 2024-02-18
Publication date: 2024-03-19
Anticipated expiration: 2044-02-18
Also published as: CN117717325B

Abstract

The embodiment of the application provides a left ventricle pressure determining system and method based on a ventricular catheter pump, relates to the technical field of medical equipment, and comprises an information acquisition module, an interference determining module and a pressure determining module, wherein: the information acquisition module is used for acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in the current cardiac cycle; the interference determination module is used for determining association characteristics representing association characteristics between the left ventricle pressure and the aortic pressure, and determining target interference characteristics representing interference characteristics of interference suffered by the optical fiber pressure sensor based on the association characteristics; the pressure determination module is configured to determine a target compensated pressure for left ventricular pressure based on the target disturbance characteristic. By applying the scheme provided by the embodiment, the real-time accurate detection of the left ventricular pressure can be realized.

Description

Left ventricle pressure determining system and method based on ventricular catheter pump

Technical Field

The application relates to the technical field of medical equipment, in particular to a left ventricular pressure determining system and method based on a ventricular catheter pump.

Background

Ventricular catheter pumps are devices that provide support or assist functions for patients suffering from heart related diseases, such as heart failure, to assist the heart in pumping blood to other parts of the body.

When the ventricular catheter pump operates, the left ventricular pressure of the heart of the patient needs to be accurately detected in real time, and various data needed by the detection of the detected left ventricular pressure are detected so as to accurately evaluate the current condition of the patient.

Disclosure of Invention

An object of an embodiment of the present application is to provide a system and a method for determining left ventricular pressure based on a ventricular catheter pump, so as to accurately detect left ventricular pressure in real time. The specific technical scheme is as follows:

in a first aspect, embodiments of the present application provide a left ventricular pressure determination system based on a ventricular catheter pump, the system comprising: a ventricular catheter pump, a controller, a pressure sensor, the ventricular catheter pump comprising: the device comprises a driving assembly, a pumping assembly, a blood inlet cage, a blood outlet cage and an optical fiber pressure sensor; wherein:

when the ventricular catheter pump is implanted into the heart to run, the driving assembly drives the pumping assembly to rotate, blood in the left ventricle is pumped from a blood inlet cage positioned in the left ventricle to a blood outlet cage positioned in the aorta, and the blood outlet cage is arranged in the main artery, and the optical fiber pressure sensor is integrated on the side of the blood inlet cage and is used for detecting the pressure of the left ventricle of a patient;

The pressure sensor is arranged outside the patient and is used for detecting the aortic pressure of the patient;

the controller comprises an information acquisition module, an interference determination module and a pressure determination module, wherein:

the information acquisition module is used for acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in the current cardiac cycle;

a disturbance determining module for determining a correlation characteristic characterizing a correlation characteristic between left ventricular pressure and aortic pressure, and determining a target disturbance characteristic characterizing a disturbance characteristic to which the optical fiber pressure sensor is disturbed based on the correlation characteristic;

and the pressure determining module is used for determining target compensation pressure of the left ventricle pressure based on the target interference characteristic, adopting the target compensation pressure to compensate the left ventricle pressure, and determining the compensated left ventricle pressure as the final left ventricle pressure of the current cardiac cycle.

In one embodiment of the present application, the interference determining module includes:

the first characteristic determining submodule is used for determining the association characteristic representing the association characteristic between the left ventricular pressure and the aortic pressure, determining target phases representing different movement conditions of the heart contained in the current cardiac cycle, and determining the target characteristic representing the phase characteristic of each target phase based on the corresponding relation between the pre-constructed heart movement phases and the movement phase characteristic;

A second feature determining sub-module, configured to calculate, for each target stage, a degree of matching between target features corresponding to the target stage, from among features included in the associated feature, and determine, based on the calculated degree of matching, a feature for the target stage, from among the associated features, as a first feature;

and the interference determination submodule is used for determining a fluctuation characteristic of the first characteristic corresponding to each target stage compared with the target characteristic corresponding to the target stage as a target interference characteristic representing the interference characteristic of the optical fiber pressure sensor in each target stage.

In an embodiment of the present application, the above-mentioned interference determining module further includes a third feature determining sub-module:

the third feature determining submodule is configured to calculate, for each target stage, a matching degree between a target feature corresponding to the target stage and a target feature corresponding to another target stage, and determine, as a second feature corresponding to the target stage, a first feature corresponding to the other target stage with the highest matching degree, before the interference determining submodule;

the interference determination submodule is specifically configured to, for each target stage, fuse a first feature and a second feature corresponding to the target stage to obtain a fused feature, determine a fluctuation feature of the fused feature corresponding to the target stage compared with a target feature corresponding to the target stage, and use the fluctuation feature as a target interference feature for representing interference characteristics of the optical fiber pressure sensor in each target stage.

In an embodiment of the present application, the interference determination submodule is specifically configured to determine an intersection feature between the first feature and the second feature, determine a set feature between the first feature and the second feature, update the set feature based on the intersection feature, and determine the updated set feature as the fusion feature.

In a second aspect, an embodiment of the present application provides a method for determining a left ventricular pressure based on a ventricular catheter pump, which is applied to a controller in a left ventricular pressure determining system, where the left ventricular pressure determining system further includes a ventricular catheter pump and a pressure sensor; the optical fiber pressure sensor is integrated on the blood inlet cage side; a pressure sensor, disposed outside the patient, for detecting aortic pressure of the patient; the method comprises the following steps:

acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle;

determining an associated feature characterizing an associated characteristic between left ventricular pressure and aortic pressure, determining a target interference feature characterizing an interference characteristic of interference suffered by the fiber optic pressure sensor based on the associated feature;

and determining a target compensation pressure of the left ventricular pressure based on the target interference characteristic, adopting the target compensation pressure to compensate the left ventricular pressure, and determining the compensated left ventricular pressure as the final left ventricular pressure of the current cardiac cycle.

In one embodiment of the present application, determining the target interference characteristic that characterizes the interference characteristic of the interference suffered by the optical fiber pressure sensor based on the correlation characteristic includes:

determining target phases which are contained in the current cardiac cycle and represent different movement conditions of the heart, and determining target features representing phase characteristics of each target phase based on a corresponding relation between a pre-constructed heart movement phase and movement phase characteristic features;

for each target stage, calculating the matching degree between target features corresponding to the target stage in the features contained in the associated features, and determining the features for the target stage in the associated features as first features based on the calculated matching degree;

for each target stage, determining a fluctuation characteristic of a first characteristic corresponding to the target stage compared with a target characteristic corresponding to the target stage as a target interference characteristic representing the interference characteristic of the interference suffered by the optical fiber pressure sensor in each target stage.

In an embodiment of the present application, before determining, for each target stage, a fluctuation characteristic of the first characteristic corresponding to the target stage compared to the target characteristic corresponding to the target stage as the target interference characteristic representing the interference characteristic of the interference suffered by the optical fiber pressure sensor in each target stage, the method further includes:

For each target stage, calculating the matching degree between the target feature corresponding to the target stage and the target features corresponding to other target stages, and determining the first features corresponding to other target stages with the highest matching degree as the second features corresponding to the target stage;

for each target stage, determining the fluctuation characteristic of the first characteristic corresponding to the target stage compared with the target characteristic corresponding to the target stage as a target interference characteristic representing the interference characteristic of the interference suffered by the optical fiber pressure sensor in each target stage comprises the following steps:

and aiming at each target stage, fusing the first characteristic and the second characteristic corresponding to the target stage to obtain a fused characteristic, and determining the fluctuation characteristic of the fused characteristic corresponding to the target stage compared with the target characteristic corresponding to the target stage as a target interference characteristic for representing the interference characteristic of the optical fiber pressure sensor in each target stage.

In an embodiment of the present application, for each target stage, fusing a first feature and a second feature corresponding to the target stage to obtain a fused feature includes:

for each target stage, determining an intersection characteristic between a first characteristic corresponding to the target stage and a second characteristic corresponding to the target stage, and fusing the updated first characteristic and second characteristic based on the first characteristic and the second characteristic corresponding to the intersection characteristic respectively to serve as fusion characteristics.

In a third aspect, embodiments of the present application provide a ventricular catheter pump comprising a drive assembly, a pumping assembly, a blood inlet cage, a blood outlet cage, and an optical fiber pressure sensor; when the ventricular catheter pump is implanted into the heart to run, the driving assembly drives the pumping assembly to rotate, blood in the left ventricle is pumped from a blood inlet cage positioned in the left ventricle to a blood outlet cage positioned in the aorta, and the blood outlet cage is arranged in the main artery, and the optical fiber pressure sensor is integrated on the side of the blood inlet cage and is used for detecting the pressure of the left ventricle of a patient.

From the above, it can be seen that, by applying the system provided by the embodiment, on one hand, the optical fiber pressure sensor is integrated on the blood inlet cage side of the ventricular catheter pump, and when the ventricular catheter pump starts to operate after being implanted into the heart of the patient, the blood inlet cage is positioned in the left ventricle of the patient, so that the optical fiber pressure sensor can detect the pressure of the left ventricle of the patient in real time. On the other hand, the controller included in the system determines the interference characteristic of the interference of the optical fiber pressure sensor by using the correlation characteristic of the correlation characteristic between the left ventricular pressure and the aortic pressure, and further determines the compensation pressure of the left ventricular pressure based on the interference characteristic, thereby compensating the left ventricular pressure. Because the correlation characteristic between the left ventricular pressure and the aortic pressure is related to the left ventricular pressure, the characteristic of the interference characteristic interfered by the optical fiber pressure sensor can be accurately determined based on the correlation characteristic, so that the target compensation pressure of the left ventricular pressure can be accurately determined, the left ventricular pressure is compensated based on the target compensation pressure, the accuracy of the determination of the left ventricular pressure is improved, and the accurate detection of the left ventricular pressure of a patient is realized. In combination with the two aspects, the real-time accurate detection of the left ventricular pressure of the patient is realized.

Of course, not all of the above-described advantages need be achieved simultaneously in practicing any one of the products or methods of the present application.

Drawings

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following description will briefly introduce the drawings that are required to be used in the embodiments or the description of the prior art, and it is obvious that the drawings in the following description are only some embodiments of the present application, and other embodiments may also be obtained according to these drawings to those skilled in the art.

Fig. 1 is a schematic structural diagram of a left ventricular pressure determining system based on a ventricular catheter pump according to an embodiment of the present application;

FIG. 2 is a schematic diagram of a pump for a ventricular catheter according to an embodiment of the present disclosure;

fig. 3 is a schematic structural diagram of a first controller according to an embodiment of the present application;

fig. 4 is a schematic structural diagram of a second controller according to an embodiment of the present application;

fig. 5 is a schematic structural diagram of a third controller according to an embodiment of the present application;

FIG. 6 is a flow chart of a first method for determining left ventricular pressure based on a ventricular catheter pump according to an embodiment of the present application;

FIG. 7 is a flow chart of a second method for determining left ventricular pressure based on a ventricular catheter pump according to an embodiment of the present application;

Fig. 8 is a flowchart of a third method for determining a left ventricular pressure based on a ventricular catheter pump according to an embodiment of the present application.

Detailed Description

The following description of the embodiments of the present application will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all, of the embodiments of the present application. Based on the embodiments herein, a person of ordinary skill in the art would be able to obtain all other embodiments based on the disclosure herein, which are within the scope of the disclosure herein.

The application provides a left ventricle pressure determining system based on a ventricular catheter pump, as shown in fig. 1, the system comprises a ventricular catheter pump 101, a controller 102 and a pressure sensor 103, and the system structure shown in fig. 1 is a sketch.

Wherein the ventricular catheter pump 101 is used to assist the heart in pumping blood. The ventricular catheter pump 101 may be an axial flow pump, and the ventricular catheter pump 101 may be attached to the apex of the left ventricle, the right ventricle, or both ventricles of the heart.

The pressure sensor 103 is placed outside the patient's body for detecting the aortic pressure of the patient. The pressure sensor 103 may be an invasive pressure sensor or a non-invasive pressure sensor;

The controller 102 is connected to the ventricular catheter pump 101 and the pressure sensor 103. The controller 102 is used to detect parameter data of the ventricular catheter pump/patient and to control the operation of the ventricular catheter pump 101.

Fig. 2 shows a schematic diagram of a ventricular catheter pump, comprising a drive assembly 201, a pumping assembly 202, a blood inlet cage 203, a blood outlet cage 204, and an optical fiber pressure sensor 205, which are connected in sequence, and the structure of the ventricular catheter pump shown in fig. 2 is a schematic diagram.

After the ventricular catheter pump is implanted at a preset position of the heart, the blood inlet cage 203 is positioned in the left ventricle, the blood outlet cage 204 is positioned in the aorta, and the driving assembly 201 and the pumping assembly 202 are also positioned in the aorta.

When the ventricular catheter pump is implanted in the heart, the drive assembly 201 drives the pumping assembly 202 in rotation, such that blood is drawn from the blood inlet cage 203 and pumped up to the blood outlet cage 204, through the blood outlet cage 204 and into the aorta. Due to the function of the ventricular catheter pump, the auxiliary cardiac pumping is realized, and the left ventricular load is unloaded.

In the ventricular catheter pump provided herein, a fiber optic pressure sensor 205 is also integrated. The fiber optic pressure sensor 205 is integrated into the blood inlet cage 203 side of the ventricular catheter pump. After the ventricular catheter pump is implanted at a preset position of the heart, the blood inlet cage 203 is positioned in the left ventricle, and the optical fiber pressure sensor 205 detects the pressure of the left ventricle.

In the configuration shown in fig. 2, the drive assembly is positioned within the heart when the ventricular catheter pump is placed in the patient. In addition to this configuration, the drive assembly may be coupled to the pumping assembly via a flexible drive shaft such that the drive assembly may be located outside the patient when the ventricular catheter pump device is placed in the patient.

Fig. 3 shows a schematic diagram of a structure of a controller, in which the controller shown in fig. 3 includes an information acquisition module 301, an interference determination module 302, and a pressure determination module 303. The above modules are specifically described below.

The information acquisition module 301 is configured to acquire left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle.

The left ventricular pressure and the aortic pressure may be obtained by the controller from the two sensors in real time, or the two sensors may store pressure information of each detected cardiac cycle into a memory, and the controller may read the left ventricular pressure and the aortic pressure of the current cardiac cycle from the memory.

The disturbance determination module 302 is configured to determine a correlation characteristic that characterizes a correlation characteristic between the left ventricular pressure and the aortic pressure, and determine a target disturbance characteristic that characterizes a disturbance characteristic to which the fiber pressure sensor is subjected based on the correlation characteristic.

The above-mentioned correlation features are used to characterize the correlation between left ventricular pressure and aortic pressure. The correlation between the left ventricular pressure and the aortic pressure can be represented by various dimensional data, such as the correlation between the pressure change directions of the left ventricular pressure and the aortic pressure, the time sequence pressure difference between the left ventricular pressure and the aortic pressure, and the like.

In determining the correlation characteristic, in one embodiment, the pressure characteristics of the left ventricle pressure and the aortic pressure can be extracted respectively, and a preset characteristic correlation analysis algorithm is adopted to perform characteristic correlation analysis on the left ventricle pressure characteristic and the aortic pressure characteristic, so as to obtain the correlation characteristic.

The target disturbance characteristic is used to characterize the disturbance characteristics of the disturbance experienced by the fiber optic pressure sensor.

Fiber optic pressure sensors are susceptible to a variety of factors within the blood environment, such as pressure changes within the left ventricle, blood within the left ventricle, and the like. These factors can severely impact the accuracy of the fiber optic pressure sensor, resulting in greater ingress and egress of the measured left ventricular pressure from the fiber optic pressure sensor to the actual value.

The pressure sensor for measuring the aortic pressure is arranged outside the body, and the optical fiber pressure sensor is arranged in the body, so that the complexity of the environment in the body is far higher than that in the external environment. Therefore, the pressure sensor arranged outside the body is disturbed far less than the optical fiber sensor arranged in the left ventricle, and then the pressure value detected by the pressure sensor is close to the actual value, and the detection precision is far higher than that of the optical fiber sensor. This conclusion was also verified in a number of simulation test experiments and animal test experiments.

Because the correlation characteristic between the left ventricular pressure and the aortic pressure is related to the left ventricular pressure, the characteristic of the interference suffered by the optical fiber pressure sensor can be accurately determined based on the correlation characteristic.

When determining the target interference feature, in one embodiment, an interference prediction model may be trained in advance, and the relevant feature is input into the interference prediction model to obtain the interference feature output by the interference prediction model as the target interference feature. The interference prediction model can be obtained by training an initial neural network model by taking a sample correlation characteristic as a training sample and taking a sample interference characteristic representing interference characteristics of interference suffered by the sample optical fiber pressure sensor as a training reference, and is used for predicting the interference characteristics of the interference suffered by the optical fiber pressure sensor. The sample association features are as follows: the characteristic of the correlation between the left ventricular pressure detected by the optical fiber pressure sensor integrated with the sample ventricular catheter pump and the aortic pressure detected by the pressure sensor placed outside the sample patient.

In determining the target interference characteristic, in another embodiment, the target interference characteristic may be calculated according to the following expression:

；

Wherein t represents the moment corresponding to the currently calculated feature,for a first preset time threshold, +.>For a second preset time threshold, +.>Representing the associated feature->Representing aortic pressure +.>Indicating left ventricular pressure, +.>Representing the pressure difference between aortic pressure and left ventricular pressure, < >>、/>、/>、/>、/>、/>All represent preset coefficients.

The pressure determining module 303 is configured to determine a target compensation pressure of the left ventricle pressure based on the target disturbance characteristic, compensate the left ventricle pressure with the target compensation pressure, and determine the compensated left ventricle pressure as a final left ventricle pressure of the current cardiac cycle.

The target disturbance characteristic is used for reflecting the disturbance characteristic of the disturbance suffered by the optical fiber pressure sensor, and the disturbance characteristic influences the accuracy of the pressure measurement value of the optical fiber pressure sensor, so that the compensation pressure of the left ventricle pressure detected by the optical fiber pressure sensor can be accurately determined based on the target disturbance characteristic.

In determining the target compensation pressure, in one embodiment, the target interference feature may be converted into an interference degree by using a first corresponding relationship constructed in advance, where each preset interference feature and a corresponding interference degree are stored in the first corresponding relationship, and the interference degree is an interference degree that reflects interference suffered by the optical fiber pressure sensor in a quantization manner. And after the interference degree is obtained, converting the interference degree into target compensation pressure by utilizing a second corresponding relation which is constructed in advance, wherein the interference degree and the corresponding compensation pressure are stored in the second corresponding relation.

In another embodiment, the target interference characteristic may be input into a pre-trained compensation pressure prediction model, so as to obtain the compensation pressure output by the compensation pressure prediction model, and the compensation pressure is used as the target compensation pressure.

The compensation pressure prediction model adopts a sample interference characteristic as a training sample, and uses the actual compensation pressure of the sample left ventricle pressure as a training reference, so as to obtain the compensation pressure for predicting the left ventricle pressure by training the initial neural network model.

The sample interference characteristic is a target interference characteristic of interference suffered by a sample optical fiber pressure sensor integrated in the sample ventricular catheter pump; the sample left ventricular pressure is the left ventricular pressure detected by the sample optical fiber pressure sensor, and the actual compensation pressure of the sample left ventricular pressure is as follows: the pressure difference between the left ventricular pressure detected by the sample optical fiber pressure sensor and the actual left ventricular pressure.

After the target compensation pressure is obtained, a sum value between the target compensation pressure and the left ventricular pressure can be calculated, and the calculated sum value is used as the compensated left ventricular pressure.

Referring to fig. 4, fig. 4 is a schematic structural diagram of a second controller according to an embodiment of the present application. The interference determination module 302 may include the following feature determination sub-module 402 and the interference determination sub-module 403, based on the embodiment corresponding to fig. 3.

The information acquisition module 401 is configured to acquire left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle.

The information obtaining module 401 is the same as the information obtaining module 301 in the embodiment corresponding to fig. 3, and will not be described herein.

A first feature determining sub-module 402, configured to determine a correlation feature that characterizes a correlation between the left ventricular pressure and the aortic pressure, determine target phases that characterize different motion situations of the heart and are included in a current cardiac cycle, and determine target features that characterize phase characteristics of each target phase based on a correspondence between pre-constructed cardiac motion phases and motion phase feature features.

The above-described target phases are used to characterize different operating conditions of the heart. Within a cardiac cycle, there are phases of systole and diastole, wherein the phases of systole and diastole can be subdivided into different phases, such as isovolumetric contraction, fast ejection, slow ejection, isovolumetric diastole and filling. The heart movement conditions in each stage are different, such as the left ventricle is fast tightened in the systole until the left ventricle pressure is higher than the aortic pressure, the aortic valve is opened, the left ventricle starts to shoot, the early-stage shooting speed is fast, and the later-stage shooting speed is gradually slowed down; when the aortic valve closes, the heart enters diastole until the next systole begins.

In determining the target phase, in one embodiment, a differential pressure between the left ventricular pressure and the aortic pressure may be calculated, and the target phase included in the current cardiac cycle may be determined based on the differential pressure change feature, the corresponding relationship between the time sequence information corresponding to each differential pressure and the cardiac motion phase, which are constructed in advance, and the calculated differential pressure and the time sequence information corresponding to each differential pressure.

In determining the target phase, in another embodiment, the current cardiac cycle may be divided according to each preset duration and the sequence of each preset duration, and the phase obtained by the division is determined as the target phase, where each preset duration corresponds to a different phase.

The target features are used to characterize the phase characteristics of each target phase, which reflect the uniqueness of each target phase. Since the heart motion reflected by each phase is different, each phase is unique from the other phases.

The phase characteristic may be a pressure difference between the left ventricular pressure and the aortic pressure and/or a pressure difference time sequence variation, a correlation between the left ventricular pressure time sequence variation and the aortic pressure time sequence variation, a correlation between the left ventricular pressure time sequence variation and the pressure difference time sequence variation, and a correlation between the aortic pressure time sequence variation and the pressure difference time sequence variation.

When the target characteristics of each target stage are determined based on a pre-established corresponding relationship, the corresponding relationship is a corresponding relationship between the heart motion stage and the motion stage characteristic characteristics, and the motion stage characteristic characteristics corresponding to each heart motion stage reflect the stage characteristics of the motion stage.

The second feature determining submodule 403 is configured to calculate, for each target stage, a degree of matching between target features corresponding to the target stage among features included in the associated features, and determine, as the first feature, a feature for the target stage among the associated features based on the calculated degree of matching.

The matching degree reflects the matching relation between each feature in the associated features and the corresponding target feature of each target stage; the higher the degree of matching, the more matching between the two features is indicated. Because the associated features comprise features with multiple dimensions, and the target features reflect unique stage characteristics of each target stage, the features most suitable for the target stages can be screened and obtained by utilizing the matching relation between each feature contained in the associated features and the target features corresponding to the target stages, and the interference information corresponding to each stage can be determined more specifically.

When calculating the matching degree, the correlation degree between each feature in the correlation features and the target feature corresponding to the target stage can be calculated according to a preset correlation degree algorithm, and the calculated correlation degree is determined to be the matching degree.

When determining the first feature, the feature with the highest matching degree may be determined as the first feature, or the feature with the matching degree larger than the preset matching degree threshold may be determined as the first feature.

The interference determination submodule 404 is configured to determine, for each target stage, a fluctuation characteristic of a first characteristic corresponding to the target stage compared to a fluctuation characteristic of a target characteristic corresponding to the target stage, as a target interference characteristic representing an interference characteristic of the optical fiber pressure sensor in each target stage.

Since the target feature reflects the feature of the stage characteristic of the target stage, the target feature reflects the characteristic of the stage from the own characteristic of the target stage; the first characteristic is a phase characteristic reflecting a target phase based on a relation between the detected left ventricular pressure and the aortic pressure, and the determined fluctuation characteristic is a fluctuation condition reflecting the first characteristic with respect to the target characteristic. Thus, the determined fluctuation feature can accurately reflect the disturbed characteristic in the pressure detection process.

In determining the fluctuation feature, in one embodiment, with the target feature as the reference feature, a feature difference between the first feature and the reference feature may be determined, and the feature difference may be determined as the fluctuation feature.

The pressure determining module 405 is configured to determine a target compensated pressure of the left ventricle pressure based on the target disturbance characteristic, compensate the left ventricle pressure with the target compensated pressure, and determine the compensated left ventricle pressure as a final left ventricle pressure of the current cardiac cycle.

As can be seen from the above, in the present embodiment, since the target feature reflects the feature of the stage characteristic of the target stage, the target feature reflects the characteristic of the stage from the own characteristic of the target stage; the first characteristic is a phase characteristic reflecting a target phase based on a relation between the detected left ventricular pressure and the aortic pressure, and the determined fluctuation characteristic is a fluctuation condition reflecting the first characteristic with respect to the target characteristic. Thus, the determined fluctuation feature can accurately reflect the disturbed characteristic in the pressure detection process.

In the foregoing embodiment corresponding to fig. 4, a third feature determination submodule may be further included before the interference determination submodule. Based on this, referring to fig. 5, fig. 5 is a schematic structural diagram of a third controller according to an embodiment of the present application. The controller includes:

The information acquisition module 501 is configured to acquire left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle;

a first feature determining sub-module 502, configured to determine a correlation feature that characterizes a correlation characteristic between the left ventricular pressure and the aortic pressure, determine target phases that characterize different motion situations of the heart and are included in a current cardiac cycle, and determine target features that characterize phase characteristics of each target phase based on a correspondence between pre-constructed cardiac motion phases and motion phase feature features.

A second feature determining sub-module 503, configured to calculate, for each target stage, a degree of matching between target features corresponding to the target stage, among features included in the associated features, and determine, as the first feature, a feature for the target stage, among the associated features, based on the calculated degree of matching.

The above 501-503 are the same as 401-403 in the corresponding embodiment of fig. 4, and will not be described again here.

The third feature determining sub-module 504 is configured to calculate, for each target stage, a matching degree between a target feature corresponding to the target stage and a target feature corresponding to another target stage, and determine a first feature corresponding to the other target stage with the highest matching degree as a second feature corresponding to the target stage.

The other target phases mentioned above refer to target phases other than the target phase currently targeted among the determined target phases.

The matching degree reflects the association relation between the target stages, and when the matching degree is highest, the relationship between the two stages is the closest. When calculating the matching degree, the correlation degree between the two features can be calculated according to a preset correlation degree algorithm, and the calculated correlation degree is determined as the matching degree.

The interference determination submodule 505 is specifically configured to, for each target stage, fuse the first feature and the second feature corresponding to the target stage to obtain a fused feature, determine a fluctuation feature of the fused feature corresponding to the target stage compared with the target feature corresponding to the target stage, and use the fluctuation feature as a target interference feature for characterizing an interference characteristic of interference suffered by the optical fiber pressure sensor in each target stage.

Because the target interference feature is determined based on the fused feature in comparison to the fluctuating feature of the target feature, the fused feature fuses the first feature and the second feature corresponding to the target stage, the first feature being for the target stage and the second feature being for the other target stage that is the closest match to the target stage. Therefore, in the application, the features corresponding to the current target stage and the other target stages which are matched with the current target stage are combined, so that the determined fusion feature can reflect the pressure change condition from the overall continuity of the heart motion, and the target interference feature can be further accurately determined based on the fusion feature.

When the first feature and the second feature are fused, feature stitching can be performed on the first feature and the second feature to serve as fusion features;

when the first feature and the second feature are fused, an intersection feature between the first feature and the second feature can be determined, the first feature and the second feature are updated respectively based on the intersection feature, and the updated first feature and the updated second feature are fused to obtain a fusion feature.

The intersection feature reflects a feature in which a coincidence occurs between the first feature and the second feature. The intersection characteristic can more accurately reflect the detection characteristic of the current target stage because the intersection characteristic is the characteristic appearing between the first characteristic and the second characteristic. And updating the first characteristic and the second characteristic by using the intersection characteristic, so that the accuracy of the updated first characteristic and second characteristic is higher.

The pressure determining module 506 is configured to determine a target compensated pressure of the left ventricular pressure based on the target disturbance feature, compensate the left ventricular pressure with the target compensated pressure, and determine the compensated left ventricular pressure as a final left ventricular pressure of the current cardiac cycle.

The 506 is identical to 404 of the embodiment corresponding to fig. 4, and will not be described again.

As can be seen from the above, in the present embodiment, since the target interference feature is determined based on the fluctuation feature of the fusion feature compared with the target feature, the fusion feature fuses the first feature and the second feature corresponding to the target stage, the first feature being for the target stage, and the second feature being for the other target stage that is the best match of the target stage. Therefore, in the application, the features corresponding to the current target stage and the other target stages which are matched with the current target stage are combined, so that the determined fusion feature can reflect the pressure change condition from the overall continuity of the heart motion, and the target interference feature can be further accurately determined based on the fusion feature.

Corresponding to the left ventricular pressure determining system based on the ventricular catheter pump, the embodiment of the application also provides a left ventricular pressure determining method based on the ventricular catheter pump.

Referring to fig. 6, fig. 6 is a flowchart of a first method for determining a left ventricular pressure based on a ventricular catheter pump according to an embodiment of the present application, where the method includes following steps S601-S603.

The method provided by the embodiment is applied to a controller in a left ventricular pressure determining system, and the left ventricular pressure determining system further comprises a ventricular catheter pump and a pressure sensor; the optical fiber pressure sensor is integrated on the blood inlet cage side; and the pressure sensor is arranged outside the patient and is used for detecting the aortic pressure of the patient.

Step S601: acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle;

step S602: determining an associated feature characterizing an associated characteristic between left ventricular pressure and aortic pressure, determining a target interference feature characterizing an interference characteristic of interference suffered by the fiber optic pressure sensor based on the associated feature;

step S603: and determining a target compensation pressure of the left ventricular pressure based on the target interference characteristic, adopting the target compensation pressure to compensate the left ventricular pressure, and determining the compensated left ventricular pressure as the final left ventricular pressure of the current cardiac cycle.

Referring to fig. 7, fig. 7 is a flow chart of a second method for determining a left ventricular pressure based on a ventricular catheter pump according to an embodiment of the present application, where the method includes the following steps S701 to S705.

Step S701: acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle;

step S702: determining the association characteristic representing the association characteristic between the left ventricular pressure and the aortic pressure, determining the target phases representing different motion conditions of the heart contained in the current cardiac cycle, and determining the target characteristic representing the phase characteristic of each target phase based on the corresponding relation between the pre-constructed cardiac motion phases and the motion phase characteristic;

step S703: for each target stage, calculating the matching degree between target features corresponding to the target stage in the features contained in the associated features, and determining the features for the target stage in the associated features as first features based on the calculated matching degree;

step S704: for each target stage, determining a fluctuation characteristic of a first characteristic corresponding to the target stage compared with a target characteristic corresponding to the target stage as a target interference characteristic representing the interference characteristic of the interference suffered by the optical fiber pressure sensor in each target stage.

Step S705: and determining a target compensation pressure of the left ventricular pressure based on the target interference characteristic, adopting the target compensation pressure to compensate the left ventricular pressure, and determining the compensated left ventricular pressure as the final left ventricular pressure of the current cardiac cycle.

Referring to fig. 8, fig. 8 is a flowchart of a third method for determining a left ventricular pressure based on a ventricular catheter pump according to an embodiment of the present application, where the method includes the following steps S801 to S806.

Step S801: acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle;

Step S802: determining the association characteristic representing the association characteristic between the left ventricular pressure and the aortic pressure, determining the target phases representing different motion conditions of the heart contained in the current cardiac cycle, and determining the target characteristic representing the phase characteristic of each target phase based on the corresponding relation between the pre-constructed cardiac motion phases and the motion phase characteristic;

step S803: for each target stage, calculating the matching degree between target features corresponding to the target stage in the features contained in the associated features, and determining the features for the target stage in the associated features as first features based on the calculated matching degree;

step S804: for each target stage, calculating the matching degree between the target feature corresponding to the target stage and the target features corresponding to other target stages, and determining the first features corresponding to other target stages with the highest matching degree as the second features corresponding to the target stage;

step S805: and aiming at each target stage, fusing the first characteristic and the second characteristic corresponding to the target stage to obtain a fused characteristic, and determining the fluctuation characteristic of the fused characteristic corresponding to the target stage compared with the target characteristic corresponding to the target stage as a target interference characteristic for representing the interference characteristic of the optical fiber pressure sensor in each target stage.

Step S806: and determining a target compensation pressure of the left ventricular pressure based on the target interference characteristic, adopting the target compensation pressure to compensate the left ventricular pressure, and determining the compensated left ventricular pressure as the final left ventricular pressure of the current cardiac cycle.

Corresponding to the left ventricle pressure determining system based on the ventricular catheter pump, the embodiment of the application also provides the ventricular catheter pump.

The ventricular catheter pump comprises a driving assembly, a pumping assembly, a blood inlet cage, a blood outlet cage and an optical fiber pressure sensor; when the ventricular catheter pump is implanted into the heart to run, the driving assembly drives the pumping assembly to rotate, blood in the left ventricle is pumped from a blood inlet cage positioned in the left ventricle to a blood outlet cage positioned in the aorta, and the blood outlet cage is arranged in the main artery, and the optical fiber pressure sensor is integrated on the side of the blood inlet cage and is used for detecting the pressure of the left ventricle of a patient.

In yet another embodiment provided herein, there is also provided a computer readable storage medium having stored therein a computer program which, when executed by a processor, implements the functions of the functional modules described in the left ventricular pressure determination system provided herein.

In yet another embodiment provided herein, there is also provided a computer program product containing instructions that, when run on a computer, cause the computer to perform the functions of the functional modules described in the ventricular pressure determination system provided in the embodiments of the present application.

In the above embodiments, it may be implemented in whole or in part by software, hardware, firmware, or any combination thereof. When implemented in software, may be implemented in whole or in part in the form of a computer program product. The computer program product includes one or more computer instructions. When loaded and executed on a computer, produces a flow or function in accordance with embodiments of the present application, in whole or in part. The computer may be a general purpose computer, a special purpose computer, a computer network, or other programmable apparatus. The computer instructions may be stored in or transmitted from one computer-readable storage medium to another, for example, by wired (e.g., coaxial cable, optical fiber, digital Subscriber Line (DSL)), or wireless (e.g., infrared, wireless, microwave, etc.). The computer readable storage medium may be any available medium that can be accessed by a computer or a data storage device such as a server, data center, etc. that contains an integration of one or more available media. The usable medium may be a magnetic medium (e.g., floppy Disk, hard Disk, magnetic tape), an optical medium (e.g., DVD), or a semiconductor medium (e.g., solid State Disk (SSD)), etc.

It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.

In this specification, each embodiment is described in a related manner, and identical and similar parts of each embodiment are all referred to each other, and each embodiment mainly describes differences from other embodiments. In particular, for apparatus, electronic devices, computer readable storage medium embodiments, since they are substantially similar to method embodiments, the description is relatively simple, and relevant references are made to the partial description of method embodiments.

The foregoing description is only of the preferred embodiments of the present application and is not intended to limit the scope of the present application. Any modifications, equivalent substitutions, improvements, etc. that are within the spirit and principles of the present application are intended to be included within the scope of the present application.

Claims

1. A left ventricular pressure determination system based on a ventricular catheter pump, the system comprising: a ventricular catheter pump, a controller, a pressure sensor, the ventricular catheter pump comprising: the device comprises a driving assembly, a pumping assembly, a blood inlet cage, a blood outlet cage and an optical fiber pressure sensor; wherein:

2. The system of claim 1, wherein the interference determination module comprises:

3. The system of claim 2, wherein the system further comprises a controller configured to control the controller,

the interference determination module further includes a third feature determination sub-module:

4. A system according to claim 3, characterized in that the interference determination submodule is configured to determine an intersection feature between the first feature and the second feature, and to determine a collection feature between the first feature and the second feature, update the collection feature based on the intersection feature, and determine the updated collection feature as a fusion feature.

5. A method for determining left ventricular pressure based on a ventricular catheter pump is characterized by being applied to a controller in a left ventricular pressure determining system, wherein the left ventricular pressure determining system further comprises the ventricular catheter pump and a pressure sensor; the optical fiber pressure sensor is integrated on the blood inlet cage side; a pressure sensor, disposed outside the patient, for detecting aortic pressure of the patient; the method comprises the following steps:

6. The method of claim 5, wherein determining a target disturbance characteristic that characterizes a disturbance characteristic of a disturbance experienced by the fiber optic pressure sensor based on the correlation characteristic comprises:

7. The method of claim 6, wherein the step of providing the first layer comprises,

before determining, for each target stage, the fluctuation characteristic of the first characteristic corresponding to the target stage compared with the target characteristic corresponding to the target stage as the target interference characteristic representing the interference characteristic of the interference suffered by the optical fiber pressure sensor in each target stage, the method further includes:

8. The method of claim 7, wherein for each target stage, fusing the first feature and the second feature corresponding to the target stage to obtain a fused feature, comprising:

9. The ventricular catheter pump is characterized by comprising a driving assembly, a pumping assembly, a blood inlet cage, a blood outlet cage and an optical fiber pressure sensor; when the ventricular catheter pump is implanted into the heart to run, the driving assembly drives the pumping assembly to rotate, blood in the left ventricle is pumped from a blood inlet cage positioned in the left ventricle to a blood outlet cage positioned in the aorta, and the blood outlet cage is arranged in the main artery, and the optical fiber pressure sensor is integrated on the side of the blood inlet cage and is used for detecting the pressure of the left ventricle of a patient.