CN117224171A - Sampling capsule, sampling capsule system and control method - Google Patents
Sampling capsule, sampling capsule system and control method Download PDFInfo
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- CN117224171A CN117224171A CN202311441629.5A CN202311441629A CN117224171A CN 117224171 A CN117224171 A CN 117224171A CN 202311441629 A CN202311441629 A CN 202311441629A CN 117224171 A CN117224171 A CN 117224171A
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- 238000005070 sampling Methods 0.000 title claims abstract description 267
- 239000002775 capsule Substances 0.000 title claims abstract description 80
- 238000000034 method Methods 0.000 title claims abstract description 22
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract description 53
- 238000005192 partition Methods 0.000 claims abstract description 41
- 238000012545 processing Methods 0.000 claims description 32
- 230000005540 biological transmission Effects 0.000 claims description 23
- 238000004891 communication Methods 0.000 claims description 22
- 230000001079 digestive effect Effects 0.000 claims description 20
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 20
- 238000000926 separation method Methods 0.000 claims description 19
- 230000008569 process Effects 0.000 claims description 8
- 230000033001 locomotion Effects 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 5
- 231100000915 pathological change Toxicity 0.000 claims description 4
- 230000036285 pathological change Effects 0.000 claims description 4
- 238000002347 injection Methods 0.000 abstract description 14
- 239000007924 injection Substances 0.000 abstract description 14
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 36
- 238000011084 recovery Methods 0.000 description 8
- 230000006872 improvement Effects 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 238000009434 installation Methods 0.000 description 4
- 238000001816 cooling Methods 0.000 description 3
- 238000006073 displacement reaction Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000010827 pathological analysis Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001808 coupling effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Radiology & Medical Imaging (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
A sampling capsule, a sampling capsule system and a control method. The sampling capsule comprises a shell, a partition wall arranged in the shell, a sampling pool formed by the partition wall and the shell arranged on the first side of the partition wall in a surrounding manner, an inner sample inlet arranged on the partition wall, an outer sample inlet arranged on the shell and on the second side of the partition wall, a sampling channel communicated with the outer sample inlet and the inner sample inlet, and a switch assembly for opening or closing the sampling channel. When the sampling capsule reaches the digestive tract part to be detected, the sampling channel is opened through the switch assembly, so that sample injection is realized; after the sample injection is finished, closing the sampling channel to prevent the sample from leaking or being polluted; and the sampling amount can be precisely controlled by controlling the opening time of the sampling channel. In addition, the switch component actively controls the opening or closing of the sampling channel, so that the sampling device can be used for any digestive tract part and has high universality.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to a sampling capsule, a sampling capsule system and a control method, wherein the sampling capsule has high universality, can accurately control sampling time and sampling amount, and can prevent samples from being leaked or polluted after sampling.
Background
The sampling capsule is an intelligent capsule which enters the digestive tract to sample digestive juice. In general, the sampling capsule comprises a sampling cavity, a sampling port communicated with the sampling cavity and a sampling port; after reaching a specific digestive tract part, the sampling port is opened, and digestive juice enters the sampling cavity; after the sampling capsule is removed from the body, the digestive juice is taken out from the sampling port for pathological analysis.
In the existing sampling capsule, a material which can be degraded under the environment of a specific digestive tract part is adopted as a sampling port, and when the sampling capsule reaches the corresponding digestive tract part, the material is degraded to form a sampling hole, so that digestive juice enters the sampling capsule under the internal and external pressure difference. However, such sampling capsules, on the one hand, have poor versatility due to the different environments within the different digestive tracts; on the other hand, the sampling amount is uncontrollable, and after the sampling is finished, the sampling hole cannot be closed again, and the sample is easy to leak or be polluted by other liquids.
In view of the foregoing, there is a need for an improved sampling capsule and sampling capsule system, control method, to address the above-mentioned problems.
Disclosure of Invention
The application aims to provide a sampling capsule, a sampling capsule system and a control method, which have high universality, can accurately control sampling time and sampling amount and can prevent samples from being leaked or polluted after sampling.
In order to achieve the above object, the present application provides a sampling capsule, comprising a housing, a partition wall arranged in the housing, and a sampling pool formed by enclosing the partition wall and the housing positioned on a first side of the partition wall; characterized in that the sampling capsule further comprises: the sampling device comprises an inner sample inlet arranged on the partition wall, an outer sample inlet arranged on the shell at the second side of the partition wall, a sampling channel for communicating the outer sample inlet with the inner sample inlet, and a switch assembly for opening or closing the sampling channel;
the wall surrounding the sampling channel comprises a first wall and a second wall which are oppositely arranged, and at least part of the first wall is an elastic wall; the switch component applies force to the elastic wall to adjust the interval distance between the elastic wall and the second wall, so that the elastic wall is attached to the second wall to close the sampling channel or open the sampling channel away from the second wall;
the switch assembly comprises a driving unit for driving the elastic wall to be close to the second wall and a control unit in communication connection with the driving unit; the driving unit comprises a micro motor in communication connection with the control unit and a top block in threaded connection with a rotor of the micro motor; when the rotor rotates, the rotor is converted into linear motion of the top block through threaded fit, so that force is applied to the elastic wall.
As a further development of the application, the top piece is not connected to the elastic wall; or the top block is connected with the elastic wall.
As a further improvement of the application, the switch assembly further comprises a sliding rail arranged on the inner wall of the housing to limit the linear movement of the top block.
As a further development of the application, the micro-motor is a motor or a stepper motor, which is located on the side of the top piece facing away from the elastic wall.
As a further improvement of the present application, the switch assembly further includes:
the sensor is in communication connection with the control unit and is used for acquiring physiological parameters and/or image information in the digestive tract; the sensor is at least one of an image sensor, a pH sensor and an ultrasonic sensor; when the sensor comprises an image sensor, part of the shell is transparent; when the sensor comprises a pH sensor, a window is formed in the shell, and the pH sensor is contacted with the digestive tract liquid through the window;
the storage module is in communication connection with the control unit and is used for storing normal physiological parameters and/or image information of different parts in the digestive tract and physiological parameters and/or image information during possible pathological changes;
and the wireless transmission module is used for being in communication connection with the external processing terminal.
As a further improvement of the present application, the partition wall is provided integrally with the housing on the first side of the partition wall; or the separation wall and the shell positioned on the first side of the separation wall are arranged in a split mode, and the tightness of the joint of the separation wall and the shell is ensured to ensure that the sampling tank can keep the required vacuum degree of-90 kPa to-80 kPa.
As a further improvement of the application, the second wall is arranged close to the partition wall, the first wall is arranged on one side of the sampling channel away from the partition wall, and the outer sample inlet is arranged between the first wall and the second wall;
or the separation wall forms the second wall, the first wall is an elastic wall which is arranged at intervals with the separation wall, the outer sample inlet is arranged between the separation wall and the elastic wall, and the sampling channel is formed between the elastic wall and the separation wall;
or, the first wall and the second wall are elastic walls, the first wall and the second wall are integrally arranged, the sampling channel is a multi-way pipe, part of pipe orifices are connected with the inner sample inlet, and the other part of pipe orifices are connected with the outer sample inlet.
The application also provides a sampling capsule system, which comprises the sampling capsule and an external processing terminal in communication connection with the switch component.
The application also provides a control method based on the sampling capsule, which comprises the following steps: judging whether sampling is needed, if so, opening the sampling channel by the switch component; after sampling is finished, the switch component closes the sampling channel.
As a further improvement of the present application, the switch assembly further includes: the sensor is in communication connection with the control unit and is used for acquiring physiological parameters and/or image information in the digestive tract; the storage module is in communication connection with the control unit and is used for storing normal physiological parameters and/or image information of different parts in the digestive tract and physiological parameters and/or image information during possible pathological changes; the wireless transmission module is used for being in communication connection with an external processing terminal; wherein,
the sensor is an image sensor, and part of the shell is transparent; the method comprises the steps that an external digestive tract image is obtained through the image sensor, the wireless transmission module transmits the obtained image to an external processing terminal, the external processing terminal processes the obtained image, the digestive tract part where the sampling capsule is located is identified, whether a focus exists or not, and whether sampling is carried out or not is determined according to the information of the digestive tract part and whether the focus exists or not;
or, the sensor is a pH sensor, a window is arranged on the shell, and the pH sensor is contacted with the digestive tract liquid through the window; the method comprises the steps of obtaining the pH value of digestive juice in the digestive tract through a pH sensor, transmitting the obtained pH value to an external processing terminal through the wireless transmission module, processing the obtained pH value to determine the position of the sampling capsule, and determining whether to sample according to the digestive tract part;
or, the sensor is an ultrasonic sensor; and the wireless transmission module transmits the acquired image to an external processing terminal, and the external processing terminal processes the acquired image, identifies the digestive tract part where the sampling capsule is positioned and whether a focus exists, and decides whether to sample according to the information of the digestive tract part and whether the focus exists.
Compared with the prior art, the application has the beneficial effects that: when the sampling capsule reaches the digestive tract part to be detected, the sampling channel is opened, and digestive juice enters the sampling pool through the outer sampling port, the sampling channel and the inner sampling port, so that sampling is realized; after the sample injection is finished, closing the sampling channel to prevent the sample from leaking or being polluted; and the sampling amount can be precisely controlled by controlling the opening time of the sampling channel. In addition, the switch component actively controls the sampling channel to be opened or closed, is not influenced by the environment of the digestive tract part, can be universally used for any digestive tract part, and has higher universality.
Drawings
FIG. 1 is a schematic view of a sampling capsule according to a preferred embodiment of the present application when a sampling channel is closed;
FIG. 2 is a schematic view of the sampling capsule shown in FIG. 1 with a sampling channel open;
FIG. 3 is a schematic cross-sectional view of a multi-way pipe according to a preferred embodiment of the present application;
FIG. 4 is a schematic cross-sectional view of a multi-way pipe according to another preferred embodiment of the present application;
FIG. 5 is a schematic view of a sampling capsule according to another embodiment of the present application when a sampling channel is opened;
FIG. 6 is a schematic view of the sampling capsule shown in FIG. 5 with the sampling channel closed;
FIG. 7 is a schematic view of a sampling capsule according to another embodiment of the present application when a sampling channel is opened;
fig. 8 is a schematic view of the sampling capsule shown in fig. 7 when the sampling channel is closed.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The present application will be described in detail below with reference to specific embodiments shown in the drawings. These embodiments are not intended to limit the application and structural, methodological, or functional modifications of these embodiments that may be made by one of ordinary skill in the art are included within the scope of the application.
In the various illustrations of the application, certain dimensions of structures or portions may be exaggerated relative to other structures or portions for convenience of illustration, and thus serve only to illustrate the basic structure of the inventive subject matter.
In addition, terms such as "upper", "above", "lower", "below", and the like, used herein to denote spatially relative positions are used for convenience of description to describe one element or feature relative to another element or feature as illustrated in the figures. The term spatially relative position may be intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "below" or "beneath" other elements or features would then be oriented "above" the other elements or features. Thus, the exemplary term "below" can encompass both an orientation of above and below. The device may be otherwise oriented (rotated 90 degrees or other orientations) and the spatially relative descriptors used herein interpreted accordingly.
Referring to fig. 1 to 8, a sampling capsule 100 and its internal structure according to a preferred embodiment of the present application are shown.
Referring to fig. 1-2 and 5-8, the sampling capsule 100 includes a housing 1, a partition wall 2 disposed in the housing 1, a sampling pool 3 formed by the partition wall 2 and the housing 1 disposed on a first side of the partition wall 2, an inner sample inlet 41 disposed on the partition wall 2, an outer sample inlet 42 disposed on the housing 1 disposed on a second side of the partition wall 2, a sampling channel 43 communicating the outer sample inlet 42 and the inner sample inlet 41, and a switch assembly 5 for opening or closing the sampling channel 43.
In general, when the sampling capsule 100 is positioned at a digestive tract portion to be inspected or reaches a digestive tract portion having a lesion, sampling is required. When the sampling capsule 100 reaches the digestive tract part to be sampled, the sampling channel 43 is opened through the switch component 5, and digestive juice enters the sampling pool 3 through the outer sampling port 42, the sampling channel 43 and the inner sampling port 41 to realize sampling; after the sample injection is finished, the sampling channel 43 is closed to prevent the sample from leaking or being polluted; and by controlling the opening time of the sampling channel 43, the sample injection amount can be precisely controlled. In addition, the switch assembly 5 actively controls the sampling channel 43 to be opened or closed, so that the sampling channel is not influenced by the special environment of the digestive tract part, can be commonly used for any digestive tract part, and has high universality.
After the sampling capsule 100 is removed from the body, the protocols for removing digestive juice include, but are not limited to: the sampling channel 43 is opened, so that the digestive juice flows out through the inner sample inlet 41, the sampling channel 43 and the outer sample inlet 42 for pathological analysis. Alternatively, the sampling capsule 100 further includes a sampling port 6 disposed on the housing 1 on the first side of the partition wall 2 and in communication with the sampling tank 3, where the sampling port 6 is made of a soft material such as rubber, and the sampling port 6 is pierced with a syringe or the like to sample the sampling tank 3.
Specifically, the shell 1 is made of any material which is harmless to human body and is not corroded by digestive juice, and the length is within 30mm, such as 27mm; diameter is within 12mm, such as 11.6mm; sampling is performed so that the sample can well enter any part in the digestive tract. And, shell 1 is formed by at least two parts concatenation, the setting installation of the inner structure of being convenient for. For example, as shown in fig. 1, the casing 1 is composed of a first casing 11, a second casing 12 and a third casing 13 which are distributed along the length direction of the sampling capsule 100, and the three parts are connected by threads, adhesive, etc.
The separation wall 2 is integrally arranged with the shell 1 positioned on the first side of the separation wall 2, so that the formed sampling pool 3 has good tightness; or the partition wall 2 is arranged separately from the housing 1 on the first side of the partition wall 2, and the tightness of the joint of the partition wall 2 and the housing is required to ensure that the sampling tank 3 can maintain the required vacuum degree.
The sampling pool 3 is a vacuum cavity with the volume being more than 0.3mL, such as 0.4 mL-0.7 mL; the vacuum degree can be between-90 kPa and-80 kPa, and the volume of the collectable digestive juice is ensured to be more than 0.3mL. Before use, the sampling channel 43 is opened, air in the sampling tank 3 is pumped by a vacuum device, and after the required vacuum degree is achieved, the sampling channel 43 is closed, so that the sampling tank 3 maintains the required vacuum degree. When the sampling capsule 100 reaches the needed digestive tract part in use, the sampling channel 43 is opened, and the digestive juice enters the sampling pool 3 under the action of internal and external pressure difference, so as to finish sampling.
Preferably, the sampling tank 3 is located at one end of the casing 1 in the length direction, the sampling tank 3, the sampling channel 43 and the switch assembly 5 are sequentially arranged along the length direction of the casing 1, so that the space utilization rate is high, and the installation is convenient.
In the present application, the number of the inner sample inlets 41 and the outer sample inlets 42 is not limited. Those skilled in the art will appreciate that: by "closing the sampling channels" is meant cutting off all channels between the inner sample inlet 41 and the outer sample inlet 42.
When the number of the outer sample inlets 42 is at least two, the at least two outer sample inlets 42 are uniformly distributed on the housing 1 along the circumferential direction of the housing 1, and the digestive juice around the sampling capsule 100 can enter the sampling pool 3, so that sampling failure caused by temporary lack of digestive juice or insufficient digestive juice in a specific part of the digestive tract can be avoided. Of course, at least two of the outer sample inlets 42 may be randomly distributed on the housing 1 along the circumferential direction of the housing 1.
When the number of the inner sample inlets 41 is at least two, at least two inner sample inlets 41 are uniformly distributed on the partition wall 2; the sample injection speed is high, and the digestive juice entering the sampling tank 3 is uniformly distributed, so that the sample injection cannot be influenced by the stacking of local digestive juice. Of course, at least two of the inner sample inlets 41 may be randomly distributed on the partition wall 2.
When the number of the inner sample inlets 41 is one and the number of the outer sample inlets 42 is at least two, the inner sample inlets 41 and all the outer sample inlets 42 are simultaneously communicated through one sampling channel 43. Specifically, the sampling channel 43 includes a plurality of ports that are in one-to-one communication with the inner sample inlet 41 and the outer sample inlet 42, and the middle is connected through a communicating pipe. Taking the example of having one inner sample inlet 41 and two outer sample inlets 42, the sampling channel 43 is T-shaped as shown in fig. 3.
When the number of the inner sample inlets 41 is at least two and the number of the outer sample inlets 42 is at least two, all the inner sample inlets 41 and all the outer sample inlets 42 may be simultaneously connected through one sample channel 43. Specifically, the sampling channels 43 are connected with the inner sample inlets 41 and the outer sample inlets 42 one by one, and the middle is connected through a communicating pipe. Taking two inner sample inlets 41 and two outer sample inlets 42 as an example, the sampling channel 43 connects the two inner sample inlets 41 and the two outer sample inlets 42 at the same time, and the sampling channel 43 is shown in fig. 4.
When the number of the inner sample inlets 41 is at least two and the number of the outer sample inlets 42 is at least two, all the inner sample inlets 41 and all the outer sample inlets 42 may be connected through a plurality of the sampling channels 43, and each of the sampling channels 43 communicates with at least one of the inner sample inlets 41 and at least one of the outer sample inlets 42. Taking two inner sample inlets 41 and two outer sample inlets 42 as an example, the connection can be achieved through two independent sampling channels 43, one end of each sampling channel 43 is communicated with one inner sample inlet 41, and the other end is communicated with one outer sample inlet 42. When the number of the inner sample inlets 41 and the number of the outer sample inlets 42 are inconsistent, the structure of the plurality of independent sample channels 43 is modified correspondingly according to the number of the inner sample inlets 41 and the number of the outer sample inlets 42 connected with each other, and the specific structure may refer to the above embodiment and will not be described herein.
In addition, the wall surrounding the sampling channel 43 includes a first wall 431 and a second wall 432 disposed opposite to each other, at least a part of the first wall 431 is an elastic wall; the switch assembly 5 applies a force to the elastic wall to adjust the distance between the elastic wall and the second wall 432, so that the elastic wall is attached to the second wall 432 to close the sampling channel 43 or open the sampling channel 43 away from the second wall 432. Those skilled in the art will appreciate that: "the switch assembly 5 applies force to the elastic wall to adjust the separation distance between the elastic wall and the second wall 432" includes the following two cases: the elastic wall adjusts the distance between the elastic wall and the second wall 432 entirely under the active control of the switch assembly 5; or in view of the elastic force of the elastic wall itself, the elastic wall jointly adjusts the distance between the elastic wall and the second wall 432 under the control of the switch assembly 5 and the action of the elastic force.
As will be appreciated by those skilled in the art, part of the first wall 431 is a flexible wall, or all of the first wall is a flexible wall, and the switch assembly 5 closes the sampling channel 43 when the flexible wall is attached to the second wall 432; when the switch assembly 5 does not act on the elastic wall, the elastic wall is restored under the self elastic force, and leaves the second wall 432 to open the sampling channel 43; or the switch assembly 5 directly drives the elastic wall away from the second wall 432, opening the sampling channel 43.
As shown in fig. 1 to 4, the first wall 431 and the second wall 432 are both elastic walls, the first wall 431 and the second wall 432 are integrally provided, the sampling channel 43 is a multi-way pipe, a part of pipe orifices are connected with the inner sample inlet 41, and another part of pipe orifices are connected with the outer sample inlet 42, so that the digestive juice does not corrode other structures during entering. For example, as shown in fig. 3, when the sampling capsule 100 is provided with one inner sample inlet 41 and two outer sample inlets 42, the multi-way pipe is T-shaped, one pipe orifice is connected with the inner sample inlet 41, and the other two pipe orifices are connected with the two outer sample inlets 42.
Preferably, the second wall 432 is disposed near the partition wall 2, the first wall 431 is disposed on a side of the sampling channel 43 away from the partition wall 2, the switch assembly 5 is disposed on a side of the first wall 431 away from the partition wall 2, and a distance between the first wall 431 and the housing 1 is relatively large, so that the switch assembly 5 is disposed and installed.
In this embodiment, the first housing 11 and the second housing 12 are separated at the outer sampling port 42, and the portion where the sampling port 42 is not provided is connected by interference fit, screw connection or adhesive. The first wall 431 is fixed to the second housing 12, and the second wall 432 is fixed to the first housing 11, so that the multi-way pipe is convenient to install.
Alternatively, as shown in fig. 5 and 6, the second wall 432 is the partition wall 2, the first wall 431 is the elastic wall spaced from the partition wall 2, the outer sample inlet 42 is disposed between the partition wall 2 and the elastic wall, and the sampling channel 43 is formed between the elastic wall and the partition wall 2. When the switch assembly 5 drives the elastic wall to be attached to the partition wall 2, the sampling channel 43 can be closed, preferably, a part of the elastic wall corresponding to the inner sample inlet 41 is attached to the partition wall 2, and the inner sample inlet 41 can be shielded at the same time, so that the sampling tank 3 is ensured to be a sealed cavity. In this embodiment, the first housing 11 and the second housing 12 may be integrally disposed, and the embodiment shown in fig. 1 or fig. 2 is disposed at the outer sampling port 42 separately, so as to facilitate the installation of the first wall 431.
Referring to fig. 1-2 and fig. 5-6, the switch assembly 5 includes a driving unit 51 for driving the elastic wall to approach the second wall 432, and a control unit 52 communicatively connected to the driving unit 51, where the control unit 52 is used for controlling the working state of the switch assembly 5.
The driving unit 51 comprises a micro motor 511 in communication connection with the control unit 52, and a top block 513 in threaded connection with a rotor 512 of the micro motor 511; when the rotor 512 rotates, the linear motion of the top block 513 is converted by the screw engagement, so that the elastic wall is forced.
The micro motor 511 has smaller load and displacement, reduces the requirements on the performance of the micro motor, ensures that the whole system has a complete, compact and concise structure and is easy to seal and sample. The micro-motor 511 includes, but is not limited to, a general motor or a stepping motor, and is capable of actively opening or closing the sampling passage 43.
In the embodiment in which the top block 513 is not connected to the elastic wall, when the rotor 512 rotates forward, the top block 513 is moved along the length direction of the sampling capsule 100 and towards the second wall 432 by screw engagement, and pushes the elastic wall to be attached to the second wall 432, so as to close the sampling channel 43; when the rotor 512 rotates reversely, the top block 513 moves away from the second wall 432, the elastic wall returns to its original state under its own elastic force, leaves the second wall 432, and opens the sampling channel 43, so that sample injection can be achieved.
Those skilled in the art will appreciate that: the amount of conduction of the sampling channel 43 can be controlled by controlling the displacement of the top block 513 along the length direction, so as to control the sampling flow rate; meanwhile, the sampling time length can be controlled through the displacement of the top block 513, so that the sample injection quantity can be accurately controlled.
Whereas in the embodiment where the top block 513 is connected to the elastic wall, the difference between the two is only that: when the rotor 512 rotates forward, the top block 513 is moved along the length direction of the sampling capsule 100 and towards the second wall 432 by screw engagement, and pushes the elastic wall to be attached to the second wall 432, so as to close the sampling channel 43; when the rotor 512 rotates reversely, the top block 513 moves away from the second wall 432, and actively pulls the elastic wall away from the second wall 432, so as to open the sampling channel 43; therefore, the distance between the elastic wall and the second wall 432 and the opening time statistics of the sampling channel 43 are more accurate, so that the sample injection amount can be controlled more accurately.
Further, the switch assembly 5 further includes a sliding rail 514 disposed on the inner wall of the housing 1 to limit the linear movement of the top block 513, so as to prevent the top block 513 from rotating with the rotor 512.
In another class of embodiments, please refer to fig. 7 and 8, which mainly differ from the embodiments shown in fig. 1-6 in that the driving unit 51 is different, and like numerals indicate like structures.
Specifically, the driving unit 51 includes a moving block 51a for driving the elastic wall to move toward or away from the second wall 432, and a driving mechanism for driving the moving block 51a to move, wherein the driving mechanism includes a shape memory alloy 51b having one end connected to the moving block 51a and the other end connected to the fixed block 51d, and a temperature control element 51c communicatively connected to the control unit 52 for controlling the temperature of the shape memory alloy 51 b. The control unit 52 is further configured to control the operating state of the switch assembly 5 by controlling the temperature control element 51c.
As will be appreciated by those skilled in the art, the position of the fixed block 51d in the sampling capsule is fixed, the position of the elastic wall being adjusted by the movement of the moving block 51 a; the moving block 51a may be connected to the elastic wall or separate from the elastic wall, and the manner in which the moving block 51a applies force to the elastic wall to move the elastic wall is the same as the manner in which the top block 513 applies force to the elastic wall to move the elastic wall, which is not described herein.
The moving block 51a and the fixed block 51d used in cooperation with each other are referred to as a set of moving block 51a and fixed block 51d. A set of moving blocks 51a and fixed blocks 51d corresponding to a shape memory alloy 51 b; or the plurality of groups of moving blocks 51a and fixed blocks 51d correspond to one shape memory alloy 51b, i.e. one shape memory alloy 51b can drive the plurality of groups of moving blocks 51a and fixed blocks 51d simultaneously; of course, it is also possible that a plurality of moving blocks 51a corresponds to one fixed block 51d, or that one moving block 51a corresponds to a plurality of fixed blocks 51d, and that the number and arrangement positions of the shape memory alloys 51b are adaptively adjusted according to the arrangement of the moving blocks 51 a.
One shape memory alloy 51b corresponds to one temperature control element 51c, or a plurality of shape memory alloys 51b corresponds to one temperature control element 51c, i.e., the temperature change of a plurality of shape memory alloys 51b is controlled by one temperature control element 51c. The number and arrangement of the temperature control elements 51c are adaptively adjusted according to the arrangement of the plurality of shape memory alloys 51 b.
The two ends of the shape memory alloy 51b are connected to the moving block 51a and the fixed block 51d, respectively, including but not limited to: the shape memory alloy 51b is disposed between the moving block 51a and the fixed block 51d, and both ends of the shape memory alloy 51b are respectively connected to both sides of the moving block 51a and the fixed block 51d. Or the shape memory alloy 51b is arranged on the same side of the moving block 51a and the fixed block 51d, and two ends of the shape memory alloy 51b are respectively connected with one side of the moving block 51a and one side of the fixed block 51d facing the shape memory alloy 51 b. Or the shape memory alloy 51b is arranged on the same side of the movable block 51a and the fixed block 51d, and two ends of the shape memory alloy 51b are respectively connected with two opposite sides of the movable block 51a and the fixed block 51d through connecting pieces. Thus, when the length of the shape memory alloy 51b is changed, the moving block 51a can be driven to move toward or away from the fixed block 51d.
When the temperature is lower than the shape recovery threshold, the shape memory alloy 51b has a first shape state, and the distance between the connection of the moving block 51a and the fixed block 51d is a first distance; when the temperature is higher than the shape recovery threshold, the shape memory alloy 51b has a second shape state, the distance between the connection of the moving block 51a and the fixed block 51d is a second distance, and the first distance is smaller than or larger than the second distance; and the greater of the first distance and the second distance is configured such that the moving block 51a applies a force to the elastic wall such that the elastic wall is fitted to the second wall 432, closing the sampling passage 43; the smaller of the first distance and the second distance is configured such that the elastic wall is separated from the second wall 432 by the driving of the moving block 51a or by self elastic force, and opens the sampling channel 43.
In one class of embodiments, the temperature control element 51c is a heating element, and the first distance is greater than the second distance. When the temperature is lower than the shape recovery threshold value, the shape memory alloy 51b is in an elongated first shape state, the moving block 51a is far away from the fixed block 51d, the moving block 51a applies force to the elastic wall to enable the elastic wall to be attached to the second wall 432, and the sampling channel 43 is in a closed state; when the heating element is turned on to heat the shape memory alloy 51b, so that after the temperature of the shape memory alloy 51b rises above a shape recovery threshold, the shape memory alloy 51b recovers a compressed, or bent, or wavy second shape state, and drives the moving block 51a to move towards the fixed block 51d, the distance between the two is reduced, the elastic wall is separated from the second wall 432 under the driving of the moving block 51a or the action of self elasticity, and the sampling channel 43 is opened, so that sample injection can be realized; when the heating element is turned off, the temperature of the shape memory alloy 51b is reduced below the shape recovery threshold temperature, and the shape memory alloy 51b is restored to the first shape state due to the double-pass effect of the shape memory alloy 51b, so that the moving block 51a is driven to move away from the fixed block 51d, and the elastic wall is pushed to be attached to the second wall 432, so that the sampling channel 43 is closed, and the sample is sealed.
In another class of embodiments, the temperature control element 51c is a cooling element, and the first distance is smaller than the second distance. When the temperature is higher than the shape recovery threshold, the shape memory alloy 51b is in an elongated second shape state, the moving block 51a is far away from the fixed block 51d, the moving block 51a applies force to the elastic wall to enable the elastic wall to be attached to the second wall 432, and the sampling channel 43 is in a closed state; when the cooling element is opened to cool the shape memory alloy 51b, so that the temperature of the shape memory alloy 51b is reduced below a shape recovery threshold, the shape memory alloy 51b recovers a compressed, or bent, or wavy first shape state, and drives the moving block 51a to move towards the fixed block 51d, the distance between the two is reduced, the elastic wall is separated from the second wall 432 under the driving of the moving block 51a or the action of self elasticity, and the sampling channel 43 is opened, so that sample injection can be realized; when the temperature of the shape memory alloy 51b rises above the shape recovery threshold after the cooling element is closed, the shape memory alloy 51b returns to the second shape state due to the double-pass effect of the shape memory alloy 51b, the moving block 51a is driven to move away from the fixed block 51d, and the elastic wall is pushed to be attached to the second wall 432, so that the sampling channel 43 is closed, and the sample is sealed.
Further, the switch assembly 5 further includes an auxiliary block 56 provided on the inner wall of the housing 1 to limit the movement of the moving block 51a in a straight line, so as to prevent the moving block 51a from being deviated. At the same time, the auxiliary block 56 may also serve to assist in the installation of other structural members.
Not limited to the embodiment shown in fig. 7 and 8, the drive unit 51 having the shape memory alloy 51b is also applicable to the sampling channel 43 shown in fig. 5 and 6.
In addition, referring to fig. 1-2 and 5-8, the switch assembly 5 further includes a sensor 53, a storage module 54, etc. communicatively connected to the control unit 52. The sensor 53 is used to collect physiological parameters and/or image information within the alimentary tract, and the information collected can be used for systematic localization to determine where the sampling capsule 100 is located and whether sampling is needed. The storage module 54 is configured to store normal physiological parameters and/or image information of different parts in the alimentary canal, and physiological parameters and/or image information of possible lesions, and the control unit 52 may compare the information obtained by the sensor 53 with the stored physiological parameters and/or image information, so as to determine the location of the sampling capsule 100 and whether the sampling needs to be performed.
The sensor 53 is at least one of an image sensor, a pH sensor, and an ultrasonic sensor; with the plurality of sensors 53, the judgment is more accurate.
Specifically, when the sensor 53 includes an image sensor, a part of the housing 1 is transparent, and the image sensor can obtain an external digestive tract image.
Or the sensor 53 comprises an ultrasonic sensor, the physiological parameters of the digestive tract are obtained by ultrasonic waves, and the housing 1 is used as an acoustic medium between the ultrasonic sensor and the object to be imaged, such as the inner wall of the digestive tract, so that the acoustic performance of the acoustic medium can provide good acoustic coupling effect, and the ultrasonic imaging quality is improved.
Or the sensor 53 comprises a pH sensor, the housing 1 has a window therein through which the pH sensor is in contact with the digestive tract fluid. As will be appreciated by those skilled in the art, the window is configured to: the digestive tract fluid can only contact the detection site of the pH sensor but cannot contact other components.
Further, the sampling capsule 100 further includes a wireless transmission module 55 for communication connection with an external processing terminal, and the wireless transmission module 55 transmits the information collected by the sensor 53 to the external processing terminal, and the external processing terminal processes the data information, so that it can more accurately determine the position where the sampling capsule 100 is located and whether the sampling needs to be performed; or the external processing terminal updates the information of the memory and the controller through the wireless transmission module 55. In addition, the information obtained by the sensor 53 is also displayed in real time by a display instrument, so as to be checked by a doctor, and the doctor can actively send a sampling instruction to sample.
In this embodiment, the storage module 54 is further configured to store information transmitted from an external processing terminal.
In the following, an embodiment with a wireless transmission module 55 will be taken as an example, how the operation state of the sampling capsule 100 is controlled with the aid of the respective sensors 53.
When the sensor 53 is an image sensor, the obtained image is transmitted to an external processing terminal through the wireless transmission module 55, the external processing terminal processes the obtained image, and the digestive tract part where the sampling capsule 100 is located is identified through human eyes and a computer vision algorithm. In addition, the doctor or algorithm can determine whether a sample is needed by determining the presence or absence of some lesions from the image. If sampling is needed, the external processing terminal transmits the information to be sampled to the control unit 52 through the wireless transmission module 55, and the control unit 52 controls the switch assembly 5 to open the sampling channel 43 for sampling. Specifically, when a specific image is identified or other specific comprehensive information appears, i.e. the sampling requirement is met, the external processing terminal may send a prompt message to the doctor to wait for the doctor to confirm, or directly send a sampling instruction to the sampling capsule 100 through the wireless transmission module 55 to start sampling.
When the sensor 53 is an ultrasonic sensor, the process is similar to that of the image sensor, and the difference is that the image is a B-ultrasonic image, which is not described herein.
When the sensor 53 is a pH sensor, the obtained pH value is transmitted to an external processing terminal through the wireless transmission module 55, so as to process the obtained pH value to determine the position of the sampling capsule 100, thereby determining whether to sample. If sampling is needed, the external processing terminal transmits the information to be sampled to the control unit 52 through the wireless transmission module 55, and the control unit 52 controls the switch assembly 5 to open the sampling channel 43 for sampling. Specifically, when a special pH value and a special pH value curve fluctuate, that is, a sampling requirement is met, the external processing terminal may send a prompt message to a doctor to wait for the doctor to confirm, or directly send a sampling instruction to the sampling capsule 100 through the wireless transmission module 55, and start sampling.
The sampling capsule 100 further includes a battery (not shown) for supplying power to the respective structures of the switching assembly 5 to ensure the normal operation of the control unit 52, the driving unit 51, the wireless transmission module 55, the storage module 54, and the sensor 53.
The application also provides a sampling capsule system, which comprises any one of the sampling capsules 100 and an external processing terminal in communication connection with the switch assembly 5. Specifically, the switch assembly 5 at least includes a control unit 52 for controlling the working state of the switch assembly 5, and a wireless transmission module 55 communicatively connected to the control unit 52, where the external processing terminal is communicatively connected to the control unit 52 through the wireless transmission module 55, so as to control the working state of the sampling capsule 100; other structures are the same as described above and are not repeated here.
The application also provides a control method based on the sampling capsule 100, which comprises the following steps: judging whether sampling is needed, if so, the switch assembly 5 opens the sampling channel 43; after the sampling is completed, the switch assembly 5 closes the sampling channel 43. Whether sampling is required or not can be determined by any of the above description modes, and will not be described in detail herein. The way in which the switch assembly 5 opens or closes the sampling channel 43 is any of the above, and will not be described herein.
In summary, when the sampling capsule 100 reaches the digestive tract to be detected, the sampling channel 43 is opened by the switch assembly 5, and the digestive juice enters the sampling tank 3 through the outer sampling port 42, the sampling channel 43 and the inner sampling port 41, so as to realize sampling; after the sample injection is finished, the sampling channel 43 is closed to prevent the sample from leaking or being polluted; and by controlling the opening time of the sampling channel 43, the sample injection amount can be precisely controlled. In addition, the switch assembly 5 actively controls the sampling channel 43 to be opened or closed, so that the sampling channel is not influenced by the environment of the digestive tract part, can be commonly used for any digestive tract part, and has high universality.
It should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is for clarity only, and that the skilled artisan should recognize that the embodiments may be combined as appropriate to form other embodiments that will be understood by those skilled in the art.
The above list of detailed descriptions is only specific to practical embodiments of the present application, and they are not intended to limit the scope of the present application, and all equivalent embodiments or modifications that do not depart from the spirit of the present application should be included in the scope of the present application.
Claims (10)
1. A sampling capsule comprises a shell, a partition wall arranged in the shell, and a sampling pool formed by enclosing the partition wall and the shell positioned on the first side of the partition wall; characterized in that the sampling capsule further comprises: the sampling device comprises an inner sample inlet arranged on the partition wall, an outer sample inlet arranged on the shell at the second side of the partition wall, a sampling channel for communicating the outer sample inlet with the inner sample inlet, and a switch assembly for opening or closing the sampling channel;
the wall surrounding the sampling channel comprises a first wall and a second wall which are oppositely arranged, and at least part of the first wall is an elastic wall; the switch component applies force to the elastic wall to adjust the interval distance between the elastic wall and the second wall, so that the elastic wall is attached to the second wall to close the sampling channel or open the sampling channel away from the second wall;
the switch assembly comprises a driving unit for driving the elastic wall to be close to the second wall and a control unit in communication connection with the driving unit; the driving unit comprises a micro motor in communication connection with the control unit and a top block in threaded connection with a rotor of the micro motor; when the rotor rotates, the rotor is converted into linear motion of the top block through threaded fit, so that force is applied to the elastic wall.
2. The sampling capsule of claim 1, wherein: the top block is not connected with the elastic wall; or the top block is connected with the elastic wall.
3. The sampling capsule of claim 1, wherein: the switch assembly further comprises a sliding rail arranged on the inner wall of the shell to limit the top block to move along the straight line.
4. The sampling capsule of claim 1, wherein: the micro motor is a motor or a stepping motor, and is positioned on one side of the top block, which is opposite to the elastic wall.
5. The sampling capsule of claim 1, wherein: the switch assembly further includes:
the sensor is in communication connection with the control unit and is used for acquiring physiological parameters and/or image information in the digestive tract; the sensor is at least one of an image sensor, a pH sensor and an ultrasonic sensor; when the sensor comprises an image sensor, part of the shell is transparent; when the sensor comprises a pH sensor, a window is formed in the shell, and the pH sensor is contacted with the digestive tract liquid through the window;
the storage module is in communication connection with the control unit and is used for storing normal physiological parameters and/or image information of different parts in the digestive tract and physiological parameters and/or image information during possible pathological changes;
and the wireless transmission module is used for being in communication connection with the external processing terminal.
6. The sampling capsule according to any one of claims 1 to 5, wherein: the partition wall is integrally provided with the housing at a first side of the partition wall; or the separation wall and the shell positioned on the first side of the separation wall are arranged in a split mode, and the tightness of the joint of the separation wall and the shell is ensured to ensure that the sampling tank can keep the required vacuum degree of-90 kPa to-80 kPa.
7. The sampling capsule according to any one of claims 1 to 5, wherein: the second wall is arranged close to the separation wall, the first wall is arranged on one side of the sampling channel, which is away from the separation wall, and the outer sample inlet is arranged between the first wall and the second wall;
or the separation wall forms the second wall, the first wall is an elastic wall which is arranged at intervals with the separation wall, the outer sample inlet is arranged between the separation wall and the elastic wall, and the sampling channel is formed between the elastic wall and the separation wall;
or, the first wall and the second wall are elastic walls, the first wall and the second wall are integrally arranged, the sampling channel is a multi-way pipe, part of pipe orifices are connected with the inner sample inlet, and the other part of pipe orifices are connected with the outer sample inlet.
8. A sampling capsule system comprising the sampling capsule of any one of claims 1-7, and an external processing terminal communicatively coupled to the switch assembly.
9. A control method based on the sampling capsule according to any one of claims 1 to 7, characterized by comprising the steps of: judging whether sampling is needed, if so, opening the sampling channel by the switch component; after sampling is finished, the switch component closes the sampling channel.
10. The control method according to claim 9, characterized in that: the switch assembly further includes: the sensor is in communication connection with the control unit and is used for acquiring physiological parameters and/or image information in the digestive tract; the storage module is in communication connection with the control unit and is used for storing normal physiological parameters and/or image information of different parts in the digestive tract and physiological parameters and/or image information during possible pathological changes; the wireless transmission module is used for being in communication connection with an external processing terminal; wherein,
the sensor is an image sensor, and part of the shell is transparent; the method comprises the steps that an external digestive tract image is obtained through the image sensor, the wireless transmission module transmits the obtained image to an external processing terminal, the external processing terminal processes the obtained image, the digestive tract part where the sampling capsule is located is identified, whether a focus exists or not, and whether sampling is carried out or not is determined according to the information of the digestive tract part and whether the focus exists or not;
or, the sensor is a pH sensor, a window is arranged on the shell, and the pH sensor is contacted with the digestive tract liquid through the window; the method comprises the steps of obtaining the pH value of digestive juice in the digestive tract through a pH sensor, transmitting the obtained pH value to an external processing terminal through the wireless transmission module, processing the obtained pH value to determine the position of the sampling capsule, and determining whether to sample according to the digestive tract part;
or, the sensor is an ultrasonic sensor; and the wireless transmission module transmits the acquired image to an external processing terminal, and the external processing terminal processes the acquired image, identifies the digestive tract part where the sampling capsule is positioned and whether a focus exists, and decides whether to sample according to the information of the digestive tract part and whether the focus exists.
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| CN202311441629.5A CN117224171A (en) | 2018-10-19 | 2018-10-19 | Sampling capsule, sampling capsule system and control method |
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| CN201811219926.4A CN109009246B (en) | 2018-10-19 | 2018-10-19 | Sampling capsule and sampling capsule system |
| CN202311441629.5A CN117224171A (en) | 2018-10-19 | 2018-10-19 | Sampling capsule, sampling capsule system and control method |
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| CN109497917A (en) * | 2019-01-11 | 2019-03-22 | 安翰科技(武汉)股份有限公司 | Alimentary canal sampling capsule |
| CN110169750A (en) * | 2019-05-21 | 2019-08-27 | 安徽协同创新设计研究院有限公司 | A kind of medical inspection device |
| CN110638412A (en) * | 2019-11-14 | 2020-01-03 | 江苏欧曼电子设备有限公司 | Capsule endoscope with body fluid sampling function |
| CN113545733A (en) * | 2020-04-24 | 2021-10-26 | 深圳馥和医疗科技有限责任公司 | Suction type selective sampling capsule and sampling system |
| CN111419293A (en) * | 2020-04-30 | 2020-07-17 | 安翰科技(武汉)股份有限公司 | Sampling/drug delivery capsule |
| CN111528924B (en) * | 2020-05-13 | 2022-05-17 | 安翰科技(武汉)股份有限公司 | Sampling capsule auxiliary tool |
| CN113331872B (en) * | 2021-05-25 | 2023-03-14 | 上海交通大学 | Miniature suction type alimentary canal multi-position liquid biopsy sampling device |
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| US5170801A (en) * | 1990-10-02 | 1992-12-15 | Glaxo Inc. | Medical capsule device actuated by radio-frequency (rf) signal |
| WO2005044094A1 (en) * | 2003-11-11 | 2005-05-19 | Olympus Corporation | Capsule type medical device system and capsule type medical device |
| JP2006061399A (en) * | 2004-08-26 | 2006-03-09 | Hitachi Ltd | Examination capsule and examination system |
| JP4593211B2 (en) * | 2004-09-08 | 2010-12-08 | オリンパス株式会社 | Capsule medical device |
| CN1631323A (en) * | 2004-11-19 | 2005-06-29 | 华南理工大学 | Remote control electromagnetic imbibition type gastrointestinal tract sampling microcapsule |
| CN101208039A (en) * | 2005-01-18 | 2008-06-25 | 皇家飞利浦电子股份有限公司 | Electronically controlled ingestible capsule for sampling fluids in alimentary tract |
| EP1861158A2 (en) * | 2005-01-18 | 2007-12-05 | Koninklijke Philips Electronics N.V. | System for controlling traversal of an ingested capsule |
| CN1820798A (en) * | 2006-01-28 | 2006-08-23 | 重庆大学 | Capsule type digestive tract medicine releasing and sampling device |
| CN101011234A (en) * | 2007-01-24 | 2007-08-08 | 重庆特奥科技有限公司 | Regulating and controlling technique of capsule endoscope |
| CN201719266U (en) * | 2010-06-08 | 2011-01-26 | 重庆金山科技（集团）有限公司 | Mini device for sampling liquid of alimentary canal |
| CN108451488B (en) * | 2018-05-04 | 2020-02-14 | 哈尔滨工业大学深圳研究生院 | Intestinal micro-capsule robot with multi-direction in-vivo sampling function |
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