CN1171927A - Ultramicroproduction method for shark cartilage - Google Patents

Abstract

The present invention relates to an ultra-microproduction method of shark bone meal. Its production process includes the following steps: cleaning shark bone, proteinase treatment, sterilizing, pulverizing, drying, disinfecting and adiabatic expansion pulverizing in cold air-flow pulverizer so as to obtain the invented shark bone meal whose grain size is up to 2 micrometers, and at the same time said invented process doesn't damage the protein of the shark bone. Said invention is simple in preparation process. easy to implement, and can provide a medicine which is non-toxic and free from side-effect for patient with carcinomatosis.

Description

Ultramicroproductionmethod method for shark cartilage

The present invention relates to the ultramicrotechnique field, exactly it is a kind of ultra micro production method of shark cartilage.

Cancer is the illness of serious threat human health.For many years, in, Western medicine all to power in conquer cancer and the development specific drug, ask the chemotherapy or the radiotherapy that can break through the general doctor trained in Western medicine of present situation singly not to kill and wound cancerous cell, simultaneously also the cell killing of health, patient's immunity is weakened in treatment, often make therapeutic process have to interrupt, and never reach satisfactory therapeutic effects.Therefore people wish to have a kind of cancer of can treating not only can suppress the generation of cancer and take for a long time but also treatment medicine that nontoxic nothing is paid the pure natural of effect creates.In recent years, anti-endotheli ocytosis therapy has caused people's very big interest, suppresses angiogenesis, cuts off the nutrition supply and the route of metastasis of tumor, can suppress growth of tumor and transfer.People have sought and have obtained polytype Angiostatin, and major part is all owing to toxicity is restricted too greatly.Animal cartilage contains the various active composition, the not long blood vessel of cartilage itself.Tumor cell seldom soaks into cartilaginous tissue, and present medical research has proved and contained the tumor cell inhibitive factor in the cartilage.And shark cartilage not only can suppress the growth of kinds of tumor cells and fresh tumor tissues culture, but also has what poison to pay effect to people's body examination." shark cartilage preparation Antitumor Effects " this piece article on the 16th the 4th phase of volume of " Chinese biochemical drug magazine " nineteen ninety-five has reported that INM is to shark cartilage preparation Antitumor Effects, experimental result proves that the shark cartilage preparation has the effect of the activity and the human body immunity improving function of stronger inhibition tumor growth.Not having obviously, the research of states such as the poison pair effect U.S., Cuba, Czech has proved that also shark cartilage mainly is that " Gu shape cancer " had stronger inhibitory action to the treatment for cancer effect.In recent years, it is the shark cartilage powder that raw material makes with the shark cartilage that states such as the U.S. produce some, and cancer is treated in combined with chemotherapy and radiotherapy, and effect is better.Healthy people takes and also can strengthen its human body resistance, reduces the generation of cancer.As " sending western Fick " shark cartilage of selling on the present market.Mainly neovascularity is outgrowth to be used for suppressing cancer to shark cartilage to suppress, and this function is mainly from its special protein.For preserving this proteinic effectiveness, protein can not heat, and also cannot be decomposed by ferment.Promptly must the (medicine) being taken before meal shark cartilage powder.Will grind shark cartilage trickle more well more exactly in addition, atomic thin particle even meet with ferment, also can just have been absorbed by enterocyte earlier before being decomposed.That is to say that the cartilage that microgranule is fine more is absorbed soon more, its effectiveness is also maximum.

The production method that the purpose of this invention is to provide a kind of shark cartilage superfine powder, it not only can produce the shark cartilage ultra micro atomic thin grain end, does not also destroy the special protein of shark cartilage.Production technology is simple simultaneously, and cost is low, realizes easily.

The objective of the invention is to be achieved by the following scheme, it is to pass through fleshing, technical processs such as cleaning, sterilization, drying, pulverizing realize, it is characterized in that: (1) washes meat on the shark bone and impurity earlier, it is 100% shark bone that the reuse hydrolysising protease removes that the remaining flesh of fish and fat back clean with clear water, and operative temperature is not higher than 45 ℃; (2) ethanol of reuse 75% is to the whole atrophic debility of bones poison of shark bone; (3) shark bone is pulverized or is cut into little determining less than 5 millimeters; (4) under aseptic condition, adopt convection current or natural drying to moisture below 15%, temperature is not more than 40 ℃, the reuse vacuum drying is to water content below 3%, baking temperature is also less than 40 ℃; Also can be dried to water content below 3% under aseptic condition in vacuum drier, temperature is less than 40 ℃; (5) dried shark bone is carried out bacterioscopy, should carry out ultraviolet sterilization if any antibacterial, reach aseptic require standard after, just can carry out next procedure; (6) drying is good shark bone is put into the cold airflow pulverizer, thicker granule through the air-flow band of high speed and high pressure enters in the pulverizing chamber by nozzle, pressure drops to atmospheric pressure generation adiabatic expansion from high pressure, make by broken particle temperature and drop to the following temperature of room temperature, this moment, fishbone was pulverized or ultra-micro powder, the shark bone powder reaches 2 microns, after check packing to dispatch from the factory.The pulverizing chamber inner high voltage is 50～110 newton/square centimeters.

Advantage of the present invention is, technology is simple, realizes that ultra micro is effective easily, and shark bone meal can reach about 2 microns, and production process is not destroyed the protein of shark bone.Keep shark cartilage to the outgrowth inhibition ability of neovascularity.But the present invention is other food of ultra micro and feedstuff also.

Below in conjunction with embodiment the present invention is done further detailed description

1, gets 100 kilograms of pure sharks, shark should not go bad, with the flesh of fish and the impurity manually removed as much as possible on the bone, to remove the remaining flesh of fish and fat back reuse clear water with hydrolysising protease then and clean and become 100% shark bone, the aforesaid operations temperature should not be higher than 45 ℃; With 75% medical alcohol to shark bone, put in order the atrophic debility of bones poison and handle; 3, shark bone is stirred skeletonization beans or the manual fritter that is cut into less than 5 millimeters with machinery, said process all should be handled under aseptic condition, can not pollution be arranged to sclerotin in carrying out said process, and operative temperature is forbidden to be higher than 40 ℃; 4, under gnotobasis, adopt convection current or natural drying to make shark bone moisture below 15%, temperature is not more than 40 ℃, and the reuse vacuum drier is dried to water content below 3%, and baking temperature is also less than 40 ℃; 5, dried shark bone is carried out bacterioscopy, should carry out ultraviolet sterilization, reach aseptic the requirement and just can carry out next procedure after the standard if any antibacterial; 6, drying is good shark bone is put into the air-flow of cold airflow pulverizer through normal temperature high voltage, enter by nozzle with thicker granule that pressure drops to atmospheric pressure from high pressure 50～110 newton/square centimeters (high pressure also can suitably be adjusted as required) at once in the pulverizing chamber, adiabatic expansion takes place, make pulverized particle temperature drop to the following temperature of room temperature, reach ultramicro powder because this variation is pulverized granule in pulverizing chamber.Owing to pulverize the low and room temperature of temperature, can reach subzeroly sometimes, so the protein component of fishbone is not destroyed, whole process is that successive powder all is to carry with air force, the equipment critical piece is made by rustless steel, and is pollution-free to shark bone in the process.Used shark bone feed particles granularity will be at-8 orders～-4 orders, and the big more powder of air-flow is thin more when producing micropowder like this, and the shark bone meal that makes can reach below 2 microns.At last the shark bone meal of pulverizing is carried out bacteriologic test, the granularity check, composition can carry out packing after the assay was approved, also can shark bone meal be made micelle according to user's situation, powdery is packed, and tablet is deposited under aseptic, dry, cryogenic condition, should charge into inert gas in case of necessity, become and the antibacterial immersion to prevent enzyme as carbon dioxide, nitrogen etc.

Claims (2)

1, Ultramicroproductionmethod method for shark cartilage, it is realized by technical processs such as fleshing, cleaning, sterilization, drying, pulverizing, it is characterized in that: (1) washes meat on the shark bone and impurity earlier, it is 100% shark bone that the reuse hydrolysising protease removes that the remaining flesh of fish and fat back clean with clear water, and operative temperature is not higher than 45 ℃; (2) ethanol of reuse 75% is to the whole atrophic debility of bones poison of shark bone; (3) shark bone is pulverized or is cut into fritter less than 5 millimeters; (4) under aseptic condition, adopt the convection type natural drying to moisture below 15%, temperature is not more than 40 ℃, the reuse vacuum drying is to water content below 3%, baking temperature is also less than 40 ℃; Also can in vacuum drier, under aseptic condition, be dried to water content 3% with, temperature is less than 40 ℃; (5) dried shark bone is carried out bacterioscopy, should carry out ultraviolet sterilization if any antibacterial, reach aseptic require standard after, just can carry out next procedure; (6) drying is good shark bone is put into the cold airflow pulverizer, thicker granule through the air-flow band of high speed and high pressure enters in the pulverizing chamber by nozzle, pressure drops to atmospheric pressure generation adiabatic expansion from high pressure, make by broken particle temperature and drop to the following temperature of room temperature, this moment, fishbone was ground into ultra-micro powder, the shark bone powder reaches 2 microns, after check packing to dispatch from the factory.

2, Ultramicroproductionmethod method for shark cartilage according to claim 1 is characterized in that: the pulverizing chamber inner high voltage is 50～110 newton/square centimeters