CN117181064A

CN117181064A - Homogenizing cup, homogenizing equipment and homogenizing process

Info

Publication number: CN117181064A
Application number: CN202311476767.7A
Authority: CN
Inventors: 李成国; 冷钢; 王世强; 马永浩
Original assignee: Youwe Zhuhai Biotechnology Co ltd
Current assignee: Youwe Zhuhai Biotechnology Co ltd
Priority date: 2023-11-08
Filing date: 2023-11-08
Publication date: 2023-12-08

Abstract

The invention belongs to the technical field of homogenization treatment, and particularly relates to a homogenization cup, homogenization equipment and a homogenization process, wherein the homogenization cup comprises a cup body, a plurality of raised strips which are circumferentially arranged at intervals are arranged on the inner side wall of the cup body, and the raised strips protrude from the inner side wall of the cup body to the central axis of the cup body; the convex strips comprise a first side surface and a second side surface which are enclosed with the inner side wall of the cup body to form a convex structure, and the first side surface and the second side surface are both smooth curved surface structures; the first side surface is a curved surface which is curved towards the outer side wall of the cup body, and the second side surface is a curved surface which is curved towards the outer side wall of the cup body; when the homogenizing cup is stirred, the central axis of the cup body and the vertical surface form an included angle. According to the homogenizing cup provided by the invention, the bulges with the smooth curved surface structures are added on the inner side wall of the cup body, so that the speed change of liquid is faster, and larger impact can be brought to the liquid in a short time, so that the macromolecular raw materials or solid particles are more fully dissolved.

Description

Homogenizing cup, homogenizing equipment and homogenizing process

Technical Field

The invention belongs to the technical field of homogenization treatment, and particularly relates to a homogenization cup, homogenization equipment and a homogenization process.

Background

In the preparation of the microneedle preparation, it is necessary to achieve the ultra-fine requirements of the liquid substance or solid particles using the liquid substance as a carrier, and therefore, it is necessary to sufficiently dissolve the polymer raw material or the material having a large particle diameter. The conventional dissolution method is to homogenize the raw material. The method is characterized in that the raw materials are placed in a tank body or a container, and shearing, impact and cavitation actions are generated on the raw materials in the tank body by means of high-speed centrifugal rotation of the tank body, so that the liquid materials or solid particles taking the liquid materials as carriers are ultra-micronized.

However, due to the fact that the homogenizing treatment period of part of materials is long, the conventional common stirring cup is used, multiple homogenizing treatments are needed, along with the multiple homogenizing treatments, the temperature of the liquid materials rises and is in a negative pressure state, water loss in the materials is increased, stability and activity of the materials are difficult to ensure, and the quality of products is finally affected due to the fact that the proportion of the materials to water is disordered, and the production process of the subsequent procedures is difficult to control. Accordingly, there has been a growing optimization of stirring cups, such as adding protrusions to the inner wall of the stirring cup to increase the shearing action on the liquid. For example, a homogenizing cup for processing a solid sample disclosed in prior art CN206823679U comprises a cup body, the cup body has a large diameter and a small diameter, the circumferential inner wall of the cup body is provided with ribs, the inner bottom of the cup body is provided with a hemispherical concave portion and is provided with a plurality of convex groove portions, and the homogenizing processing effect is improved.

However, the ribs or the protrusions are simply added, and when negative effects such as excessive temperature rise of the solution and water evaporation are generated in the homogenizing process due to friction stir of the ribs and the protrusions, a large number of bubbles are easily generated, so that the bubbles are further required to be eliminated, or else, the subsequent microneedle preparation cannot be performed, so that the prior art is complex in treatment process and limited in homogenizing treatment period.

Disclosure of Invention

In order to solve the technical problems in the prior art, the invention provides a homogenizing cup, homogenizing equipment and homogenizing process, which can effectively shorten the homogenizing treatment period and avoid overlarge temperature rise of liquid and generation of bubbles.

In order to achieve the above purpose, the technical scheme of the invention is as follows:

a homogenizing cup comprises a cup body, wherein a plurality of raised strips are arranged on the inner side wall of the cup body at intervals in the circumferential direction, and the raised strips protrude from the inner side wall of the cup body to the central axis of the cup body; the convex strips comprise a first side surface and a second side surface which are enclosed with the inner side wall of the cup body to form a convex structure, and the first side surface and the second side surface are both smooth curved surface structures; the first side surface is a curved surface which is curved towards the outer side wall of the cup body, and the second side surface is a curved surface which is curved towards the outer side wall of the cup body;

when the homogenizing cup is stirred, the central axis of the cup body and the vertical surface form an included angle.

Further, along the length extending direction of the raised strips, all the raised strips extend from the opening of the cup body towards the bottom of the cup body, and a plurality of raised strips extend and intersect at the bottom of the cup body.

Further, the cross section aspect ratio of the raised strips is 1:5-1:8.

further, the cross-sectional aspect ratio of the raised strips is 1:6.

further, the ratio of the height of the cross section of the raised strip to the diameter of the inner wall of the cup body is 1:15-1:25.

further, the ratio of the height of the cross section of the raised strip to the diameter of the inner wall of the cup body is 1:20.

further, the radians of the first side face and the second side face are 40-75 degrees.

Further, the first side surface and the second side surface are tangential to the inner side wall of the cup body.

Further, the number of the raised strips is 2 or 3.

Further, a clamping groove is vertically formed in the side wall of the outer periphery of the cup body, and the clamping groove is embedded with the homogenizing equipment; the periphery lateral wall of cup sets up the button hand of circumference extension.

The invention also provides homogenizing equipment, which comprises a revolution mechanism, a rotation mechanism and a homogenizing cup, wherein the rotation mechanism is arranged on one side of the revolution mechanism and driven by the revolution mechanism to perform revolution motion, and the homogenizing cup is arranged on the rotation mechanism and driven by the rotation mechanism to perform rotation motion; the homogenizing cup adopts the homogenizing cup of any one of the above.

The invention also provides a homogenizing process, which adopts the homogenizing equipment, wherein the revolution speed of the homogenizing cup sequentially runs according to 5 speed grades, and the 5 speed grades are set as、/>、/>、/>、/>And->，/>The method comprises the steps of carrying out a first treatment on the surface of the Wherein (1)>，/>The stirring time period for each speed stage is 1-10 minutes.

Further, at a speed ofThird speed of (2)After the stirring of the degree grade, the revolution mechanism and the rotation mechanism are stopped, and the rotation is continued by the inertia of the homogenizing equipment, wherein the stopping time is 10s-60s.

Further, the rotation speed of the homogenizing cup and the revolution speed are correspondingly set to 5 speed grades, and the rotation speed of each grade is 75% -95% of the revolution speed of the corresponding grade.

Compared with the prior art, the invention has the following beneficial effects:

according to the homogenizing cup provided by the invention, the bulges with the smooth curved surface structures are added on the inner side wall of the cup body, so that the speed change of liquid is faster, and larger impact can be brought to the liquid in a short time, so that the macromolecular raw materials or solid particles are more fully dissolved.

The homogenizing cup provided by the invention limits the height-width ratio of the cross section of the bulge, limits the ratio of the height of the cross section of the bulge to the diameter of the inner side wall of the cup body, ensures that the liquid generates sufficient vortex effect in the stirring process and does not cause excessive centrifugal force, further can promote the homogenizing process, shortens the homogenizing treatment period and avoids excessive temperature rise of the liquid.

According to the homogenizing cup provided by the invention, the first side surface and the second side surface are connected through the round corners, and the first side surface and the second side surface are tangent to the inner side wall of the cup body, so that excessive collision and friction between liquid in the cup body and the cup body in the stirring process are avoided, and the solution stability is influenced.

According to the homogenizing process provided by the invention, the stirring processes of rising and falling are adopted, and by combining the homogenizing cup provided by the invention, the stirring processes of different heights and different levels in the radial direction of the cup body can be realized under different rotating speeds, the uniform stirring of the whole solution is realized, and the problems that the solution cannot be completely dissolved due to low-speed stirring or the liquid temperature rise is too high and the water loss is serious due to high-speed stirring are avoided.

Drawings

Fig. 1 is a schematic structural view of the homogenizing cup of the present invention.

FIG. 2 is a schematic view of another angular configuration of the homogenizing cup of the present invention.

FIG. 3 is a schematic cross-sectional view of the internal protrusion of the homogenizing cup of the present invention.

FIG. 4 is a graph showing the variation of liquid velocity for a homogenizing cup of the present invention at the same stirring speed as in the prior art.

Fig. 5 is a schematic structural view of the homogenizing apparatus of the present invention.

FIG. 6 is a schematic representation of the homogenization process of the present invention showing the dissolution of a liquid after agitation.

FIG. 7 is a schematic representation of the homogenization process of the present invention showing the dissolution of a liquid after agitation.

FIG. 8 is a schematic representation of the homogenization process of the present invention showing the dissolution of a liquid after agitation in example 10.

FIG. 9 is a view showing the dissolution of the liquid after stirring in comparative example 1 of the homogenizing process of the present invention.

FIG. 10 is a view showing the dissolution of the liquid after stirring in comparative example 2 of the homogenizing process of the present invention.

FIG. 11 is a view showing the dissolution of the liquid after stirring in comparative example 3 of the homogenizing process of the present invention.

FIG. 12 is a view showing the dissolution of the liquid after stirring in comparative example 4 of the homogenization process of the present invention.

FIG. 13 is a view showing the dissolution of the liquid after stirring in comparative example 5 of the homogenizing process of the present invention.

Reference numerals illustrate:

1. the cup body comprises a cup body, 2, convex strips, 201, a first side surface, 202, a second side surface, 3, a clamping groove, 4, a buckle, 5, a revolution mechanism, 6 and a rotation mechanism.

Detailed Description

The technical solutions of the present invention will be clearly described below with reference to the accompanying drawings, and it is obvious that the described embodiments are not all embodiments of the present invention, and all other embodiments obtained by a person skilled in the art without making any inventive effort are within the scope of protection of the present invention.

It should be noted that the relative arrangement of the components and steps, numerical expressions and numerical values set forth in these embodiments should not be construed as limiting the scope of the present invention unless it is specifically stated otherwise. Furthermore, it should be understood that the dimensions of the various elements shown in the figures are not necessarily drawn to actual scale, e.g., the thickness, width, length, or distance of some elements may be exaggerated relative to other structures for ease of description.

The following description of the exemplary embodiment(s) is merely illustrative, and is in no way intended to limit the invention, its application, or uses. Techniques, methods, and apparatus known to one of ordinary skill in the relevant art may not be discussed in detail herein, but where applicable, should be considered part of the present specification.

First aspect: homogenizing cup

Example 1

As shown in fig. 1 and 3, the present embodiment provides a homogenizing cup, which comprises a cup body 1, wherein a plurality of raised strips 2 are circumferentially arranged on the inner side wall of the cup body 1 at intervals, and the raised strips 2 protrude from the inner side wall of the cup body to the central axis of the cup body; the convex strips comprise a first side surface 201 and a second side surface 202 which are surrounded by the inner side wall of the cup body to form a convex structure, and the first side surface 201 and the second side surface 202 are both smooth curved surface structures. The raised strips 2 can extend parallel to the central axis of the cup body, and can also have a small range of inclination angles; during stirring, the homogenizing cup is obliquely arranged, specifically, the central axis of the homogenizing cup is arranged at an included angle with the vertical plane, and the internal convex strip structure is driven to stir and homogenize the solution through the rotation of the cup body 1.

The first side 201 and the second side 202 are disposed at an included angle, the first side 201 is a curved surface curved toward the outer sidewall of the cup body 1, and the second side 202 is a curved surface curved toward the outer sidewall of the cup body, that is, a concave curved portion is disposed between the first side 201 and the second side 202 and on the inner sidewall of the cup body 1. During stirring, the solution flows on the inner side wall of the cup body 1, and the first side surface 201 or the second side surface 202 of the convex strip structure shears and stirs the solution, and because the first side surface 201 and the second side surface 202 are arc-shaped curved surface structures, the adjacent convex strip structures travel U-shaped guide walls, so that the liquid does wave wrapping motion from the axis of the cup body in the guide walls. Curved surface-free raised strips in the prior art cannot realize curved wave wrapping, only can realize disturbance, and the vortex wrapping effect appears in the crossing department of this embodiment under the curved surface structure drive in first side 201 and second side 202 to continue to rotate stirring through the another side, continue to stir the solution through the guide wall of U type, make the solution realize twice (or many times) shearing stirring effect on single raised strip structure, and then realize the homogeneity processing to macromolecular material. Meanwhile, the material body after liquid preparation is prevented from being too high in temperature under high rotation, meanwhile, the running load of equipment can be reduced, and the service life of the equipment is prolonged; after the homogenization treatment is finished, the subsequent material pouring process is also facilitated, and tools such as a material spoon and the like are used for cleaning and scraping the material body on the outer side wall of the cup body and the convex strip structure.

As shown in fig. 3, the liquid makes a uniform motion in the cup body, so that the velocity direction is along the tangential direction of the inner wall. When running at constant speed, the liquid encounters the wave wrapping motion, and the speed direction can be changed, so that when encountering the bulges with the arc-shaped curved surface structure, the liquid can locally form countless small vortex and can locally perform variable-speed circular motion. In particular analysis, as liquid enters the first side 201 from the inner wall, the force is split into centripetal force directed towards the center of the circle and other forces F _t ，F _t The tangential acceleration provided is opposite to the speed of the cup body, so that the cup body does deceleration movement; f when liquid enters the first side surface up to the middle inflection point of the first side surface _t The reverse acceleration provided becomes larger gradually, so the speed becomes smaller, the change speed is faster, and the acceleration is still reversed when the curve inflection point reaches the highest position of the convex strip 2, but along with F _t The acceleration provided decreases as well, so the speed continues to decrease, but the rate of change of speed is slow. Similarly, after passing the highest point of the ridge 2, it enters the second side 202, F _t The acceleration is the same as the original speed, and F is from the highest position of the convex strip 2 to the curve inflection point of the second side 202 _t The acceleration provided is gradually increased, the speed is increased, and the speed change is rapid; f at the inflection point of the curve of the second side 202 to the final position near the inner wall _t Gradually decreasing, the acceleration provided gradually decreases, the speed becomes greater, the velocityThe change is slow. Until the whole convex strip 2 passes, the uniform circular motion is continuously carried out along the inner wall.

Therefore, after the convex strip structure of the arc-shaped curved surface is added, when the material body at the inner wall of the cup body passes through the convex strip 2, the acceleration change is caused by friction, so that the speed is rapidly changed after the speed is reduced, and the material body is fully dissolved.

Fig. 4 is a graph of the velocity change of the material body according to the present embodiment and the prior art, wherein the cross section of the convex strip is triangular. In fig. 4, the wave impeller represents the structure of the homogenizing cup provided in this embodiment, and the common impeller represents the structure of the homogenizing cup with triangular section of the convex strip in the prior art. The comparison conditions are: the cup body has the same diameter and performs the same uniform circular motion. As can be seen from fig. 4, the homogenizing cup of the present embodiment can make the speed change of the solution faster, and the impact is larger in a short time, so as to ensure more sufficient dissolution.

Example 2

This embodiment differs from embodiment 1 in that: the height-width ratio of the cross section of the convex strip 2 is 1:5-1:8, wherein the height of the cross section of the convex strip 2 is h as shown in fig. 3, and the width of the cross section of the convex strip 2 is w as shown in the figure; when the aspect ratio is too large, the circumferential widths of the first side 201 and the second side 202 are too small, so that the solution cannot be fully in flow contact with the first side 201 and the second side 202 in the stirring process, the turbulent stirring effect cannot be realized, and the homogeneity degree of the solution is affected; when the aspect ratio is too small, the circumferential widths of the first side 201 and the second side 202 are too large, so that the arc curvatures of the first side 201 and the second side 202 are affected, the radian between the first side 201 and the second side 202 is too straight, and the solution cannot be sufficiently guided, so that a vortex effect is generated. The preferable ratio of the height to width ratio of the cross section of the raised strips 2 is 1:6.

example 3

This embodiment differs from embodiment 1 or embodiment 2 in that: the ratio of the height of the cross section of the raised strips 2 to the diameter of the inner wall of the cup body 1 is 1:15-1:25. when the ratio of the height of the cross section of the raised line 2 to the diameter of the inner wall of the cup body 1 is too large, the height of the cross section of the raised line structure is too large, so that the internal volume of the cup body 1 is excessively large, vortex generated in the stirring process is relatively complex, the center of gravity of the cup body is greatly changed, the equipment stability of the homogenizing process is easily affected, meanwhile, the raised line structure with too large height causes larger resistance and impact to the raised line in the stirring process, and the damage risk of the raised line structure is increased. When the ratio of the height of the cross section of the raised strips to the diameter of the inner wall of the cup body is too small, the height of the raised strips 2 is small, and the stirring effect is poor. The ratio of the height of the cross section of the raised strip 2 to the diameter of the inner wall of the cup body 1 is preferably 1:20.

example 4

This embodiment differs from embodiment 1 in that: the radian of the first side 201 and the second side 202 is 40 ° -75 °, and the greater the radian, the greater the degree of recession of the first side 201 and the second side 202. When the radian exceeds 75 degrees, the centrifugal vortex formed by the whole feed liquid in a small range changes in the homogenizing and stirring process, and the whole tank body is not easy to maintain a relative balance state during centrifugation, so that the problems of abnormal sound of equipment and the like are caused; and when the feed liquid volume is larger than the volume of the cup body 1, the risk of easily sprinkling feed liquid exists. When the radian is smaller than 40 degrees, the whole curve is relatively gentle and approaches to a straight line state, at the moment, vortex is not easy to form locally, the change of shearing force is extremely low, and large impact is not easy to be caused by feeding liquid.

Preferably, the bending curvature of the first side 201 and the second side 202 is set to be 50 degrees, the speed change process is performed in the feed liquid homogenizing process, and the friction force is changed differently, so that the feed liquid is dissolved more fully, and the damage risk of equipment is not easy to occur.

Wherein the radians of the first side surface 201 and the second side surface 202 are the same, the radian of the first side surface is denoted as alpha, the cross section width of the convex strip is denoted as w, the inner diameter of the cup body is denoted as d, and 4 is satisfied，0.01<k<0.15 for the width of sand grip 2, the diameter of cup 1 and the radian collocation of first side 201 are suitable, so, can make the sand grip structure satisfy the stirring of whole solution even simultaneously, avoid low-speed stirring to lead to the solution unable complete dissolution or high-speed stirring to lead to sand grip structure and liquid friction contact to lead to the temperature rise too high and moisture lossSevere.

Under the same rotating speed condition, when the ratio of the inner diameter d to the width w is fixed, and the radian alpha is 40 degrees, the friction force change amplitude is relatively smaller when the liquid passes through the cross section of the raised strips 2, and the time for complete stirring is longer; when the radian alpha is 70 degrees, the friction force variation amplitude is larger, so that the liquid solubility is better, but the temperature is higher during stirring, and the water loss is relatively more; when the radian alpha is 50 degrees, the change range trend of the obvious friction force from small to large and from large to small is provided, the radian is relatively gentle, and the solution temperature rise is not affected excessively while the stirring is uniform.

When the radian is smaller than 40 degrees, for example, 25 degrees, the change of the radian mutation is very small, the radian of the convex strip 2 is almost consistent with that of the cup body 1, the trend of friction force variation basically does not exist, obvious vortex shearing can not be caused in a part, and the movement trend of the feed liquid is the same as that in a circular cup body without the convex strip. When the radian is greater than 75, for example 85, because the radian that sets up is great, the change of frictional force is sharp obvious, and the liquid dissolves more fully, but the temperature rise is more obvious, and the water loss increases, simultaneously because the radian is great, can cause the sand grip to protrude the position comparatively thinly, increases the risk of damaging the sand grip in the stirring process.

The connecting line between the first side 201 and the second side 202 adopts a round corner connection, and the radian of the whole round corner curve is 130-140 degrees. Through fillet connection's sand grip structure, better realization stirring in-process solution is from the transition of first side 201 towards the another side to reduce the inside sharp-pointed part of cup 1, reduce sand grip 2 wearing and tearing.

Example 5

This embodiment differs from embodiment 4 in that: the horizontal interface of the inner side wall of the cup body 1 is circular, and the first side surface 201 and the second side surface 202 are tangential to the inner side wall of the cup body 1. The solution can flow from the inner wall of the cup body to the first side surface 201 or the second side surface 202 better, so that the solution flow is more stable, and excessive collision and friction between the solution and the cup body 1 are avoided.

Example 6

This embodiment differs from embodiment 1 in that: the number of the protrusions 2 is 3, and in other embodiments, the number of the protrusions 2 may be set to 2 or more. In this embodiment, 3 protruding strips 2 extend along the inner side wall of the cup body towards the bottom of the cup body 1, and continue to extend horizontally until intersecting after extending to the bottom of the cup body 1, and the intersecting point is located at the center of the bottom of the cup body 1. Further improving stirring turbulent flow effect and improving homogenizing treatment efficiency.

Example 7

This embodiment differs from embodiment 1 in that: as shown in fig. 2, a clamping groove 3 is vertically arranged on the peripheral side wall of the cup body 1, and the clamping groove 3 is embedded with homogenizing equipment; the periphery lateral wall of cup 1 sets up the button 4 of circumference extension, conveniently holds the homogeneity cup through button 4 operating personnel.

Second aspect: homogenizing equipment

As shown in fig. 5, the homogenizing apparatus provided in the present embodiment includes a revolution mechanism 5, rotation mechanisms 6, and a homogenizing cup, the rotation mechanisms 6 are disposed on one side of the revolution mechanism 5 and are driven by the revolution mechanism 5 to perform revolution motion, in the present embodiment, two rotation mechanisms 6 are disposed, and the two rotation mechanisms 6 are disposed on both sides of the revolution mechanism 5, respectively. The homogenizing cup is arranged on the autorotation mechanism 6 and is driven by the autorotation mechanism 6 to perform autorotation motion; the homogenizing cup adopts the homogenizing cup of any one of the above embodiments 1-7. And, after the homogenizing cup is placed in the rotation mechanism 6, the axis of the cup body has a certain included angle with the vertical direction, and the preferable included angle is 40 degrees.

In the stirring process, the revolution mechanism 5 drives the two rotation mechanisms 6 to revolve around the center of the revolution mechanism, the homogenizing cup synchronously revolves, and simultaneously, the homogenizing cup rotates around the axis of the homogenizing cup under the driving of the rotation mechanism 6, so that the liquid in the homogenizing cup is caused to generate vortex motion, and the homogenizing treatment effect is achieved.

Third aspect: homogenizing process

The embodiment provides a homogenizing process, and adopts the homogenizing equipment provided by the invention, wherein the revolution speed of the homogenizing cup sequentially runs according to 5 speed grades, and the 5 speed grades are set as、/>、/>、/>、/>And->，The method comprises the steps of carrying out a first treatment on the surface of the Wherein (1)>，/>The stirring time period for each speed stage is 1-10 minutes.

At a speed ofAfter stirring at the third speed level, stopping the revolution mechanism and the rotation mechanism, and continuing to rotate by means of self inertia of the homogenizing equipment, wherein the stopping time is 10s-60s.

The rotation speed of the homogenizing cup corresponds to the revolution speed by setting 5 speed grades, and the rotation speed of each grade is 75% -95% of the revolution speed of the corresponding grade.

Through the speed up-shifting and the speed down-shifting change that divide into the multistage with rotation speed, combine the wave parcel motion that sand grip structure and solution stirring formed, under different rotational speeds, through the change of centrifugal force for the radial distance size of the wave that sand grip structure stirring formed and cup inner wall is different, consequently can realize the radial different high different under-height stirring misce bene of cup, make the even stirring of whole solution, avoid the solution can't dissolve completely under the continuous low rotational speed, or the solution is high friction for a long time with the jar body under the continuous high rotational speed and is led to the liquid to heat up and appear the condition of loss moisture.

Example 8

In the embodiment, the homogenizing equipment provided by the invention is adopted, the height-width ratio of the cross section of the bulge 2 is 1:6, the ratio of the height of the cross section of the bulge 2 to the diameter of the inner side wall of the cup body is 1:20, and the number of the bulges 2 is 3. The homogenized raw materials are 5kg, and the raw materials comprise 70% pure water and 30% sodium hyaluronate by mass ratio; the revolution speed, rotation speed and stirring time data are shown in table 1.

Table 1 homogenization process data in example 8

Example 9

In the embodiment, the homogenizing equipment provided by the invention is adopted, the height-width ratio of the cross section of the bulge 2 is 1:6, the ratio of the height of the cross section of the bulge 2 to the diameter of the inner side wall of the cup body is 1:20, and the number of the bulges 2 is 3. The homogenized raw materials are 5kg, and the raw materials comprise 70% pure water and 30% sodium hyaluronate by mass ratio; the revolution speed, rotation speed and stirring time data are shown in table 2.

Table 2 homogenization process data in example 9

Example 10

In the embodiment, the homogenizing equipment provided by the invention is adopted, the height-width ratio of the cross section of the bulge 2 is 1:6, the ratio of the height of the cross section of the bulge 2 to the diameter of the inner side wall of the cup body is 1:20, and the number of the bulges 2 is 3. The homogenized raw materials are 5kg, and the raw materials comprise 70% pure water and 30% sodium hyaluronate by mass ratio; the revolution speed, rotation speed and stirring time data are shown in table 3.

Table 3 homogenization process data in example 10

Comparative example 1

The difference between this comparative example and example 8 is that the revolution speed and the rotation speed are different, and the same homogenizing cup as in example 8 is used as the homogenizing cup in this comparative example, and the homogenized raw material is the same as in example 8. The revolution speed, rotation speed and stirring time data in comparative example 1 are shown in table 4.

Table 4 homogenization process data in comparative example 1

Comparative example 2

The homogenizing cup in this comparative example was a smooth cup body without a convex strip structure, the inner diameter of the cup body was the same as that of the homogenizing cup used in example 8, and the homogenized raw material was the same as in example 8. The revolution speed, rotation speed and stirring time in comparative example 2 were the same as those in example 8.

Comparative example 3

The homogenizing cup in this comparative example was a smooth cup body without a convex strip structure, the inner diameter of the cup body was the same as that of the homogenizing cup used in example 9, and the homogenized raw material was the same as in example 9. The revolution speed, rotation speed and stirring time in comparative example 3 were the same as those in example 9.

Comparative example 4

The difference between this comparative example and example 8 is that the revolution speed and the rotation speed are different, and the same homogenizing cup as in example 8 is used as the homogenizing cup in this comparative example, and the homogenized raw material is the same as in example 8. The revolution speed, rotation speed and stirring time data in comparative example 4 are shown in Table 5

Table 5 homogenization process data in comparative example 4

Comparative example 5

The difference between this comparative example and example 8 is that the revolution speed and the rotation speed are different, and the same homogenizing cup as in example 8 is used as the homogenizing cup in this comparative example, and the homogenized raw material is the same as in example 8. The revolution speed, rotation speed and stirring time data in comparative example 5 are shown in Table 6

Table 6 homogenization process data in comparative example 5

After the homogenization was completed, the dissolution of the liquid was observed by naked eyes as shown in fig. 6 to 13, and the temperature of the dissolved liquid was measured by an infrared thermometer, and the weight (discharge amount) of the dissolved liquid was measured by a weighing instrument, and the specific measurement results are shown in table 7.

Table 7 comparison of dissolution results for examples and comparative examples

According to the dissolution results of the embodiment and the comparative example, the homogenization process provided by the invention is combined with the homogenization cup provided by the invention, and the arc-shaped raised strip structure is combined by adopting the multi-step lifting rotating speed setting, so that the material can be fully dissolved under the condition of lower overall rotating speed, the problems of overhigh temperature rise and serious water loss in the liquid stirring process can be avoided, and the macromolecular raw material is fully and stably dissolved.

The above embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to examples, it should be understood by those skilled in the art that modifications and equivalents may be made thereto without departing from the scope of the technical solution of the present invention, which is intended to be covered by the claims of the present invention.

Claims

1. The homogenizing cup comprises a cup body and is characterized in that a plurality of raised strips which are arranged at intervals in the circumferential direction are arranged on the inner side wall of the cup body, and the raised strips protrude from the inner side wall of the cup body to the central axis of the cup body; the convex strips comprise a first side surface and a second side surface which are enclosed with the inner side wall of the cup body to form a convex structure, and the first side surface and the second side surface are both smooth curved surface structures; the first side surface is a curved surface which is curved towards the outer side wall of the cup body, and the second side surface is a curved surface which is curved towards the outer side wall of the cup body;

2. The homogenizing cup of claim 1, wherein the first side and the second side each have an arc of 40 ° to 70 °.

3. The homogenizing cup of claim 2 wherein the first side and the second side have the same curvature, wherein the curvature of the first side is denoted as α, wherein the cross-sectional width of the rib is denoted as w, wherein the inner diameter of the cup is denoted as d, and wherein 4 is satisfied，0.01<k<0.15。

4. A homogenizing cup according to claim 3, wherein the ribs have a cross-sectional aspect ratio of 1:5-1:8.

5. a homogenizing cup according to claim 3, wherein the ratio of the height of the cross section of the rib to the diameter of the inner wall of the cup is 1:15-1:25.

6. the homogenizing cup of claim 1 wherein the ribs extend along their length from the opening of the cup toward the bottom of the cup, and wherein a plurality of the ribs intersect at the bottom of the cup.

7. The homogenizing equipment comprises a revolution mechanism, a rotation mechanism and a homogenizing cup, and is characterized in that the rotation mechanism is arranged on one side of the revolution mechanism and driven by the revolution mechanism to perform revolution motion, and the homogenizing cup is arranged on the rotation mechanism and driven by the rotation mechanism to perform rotation motion; the homogenizing cup of any one of claims 1-6.

8. A homogenizing process wherein the revolution speed of the homogenizing cup is sequentially operated in 5 speed stages, 5 speed stages being set as、/>、/>、/>、/>And->，/>The method comprises the steps of carrying out a first treatment on the surface of the Wherein (1)>，/>The stirring time period for each speed stage is 1-10 minutes.

9. The homogenizing process of claim 8, wherein the speed isAfter stirring at the third speed level, stopping the revolution mechanism and the rotation mechanism, and continuing to rotate by means of self inertia of the homogenizing equipment, wherein the stopping time is 10s-60s.

10. The homogenizing process of claim 8, wherein the rotation speed of the homogenizing cup corresponds to the revolution speed by 5 speed steps, and the rotation speed of each step is 75% -95% of the revolution speed of the corresponding step.