CN116636544A - Synergistic additive and indoxacarb lufenuron liquid preparation - Google Patents
Synergistic additive and indoxacarb lufenuron liquid preparation Download PDFInfo
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- CN116636544A CN116636544A CN202310420079.2A CN202310420079A CN116636544A CN 116636544 A CN116636544 A CN 116636544A CN 202310420079 A CN202310420079 A CN 202310420079A CN 116636544 A CN116636544 A CN 116636544A
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- indoxacarb
- lufenuron
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- 239000005912 Lufenuron Substances 0.000 title claims abstract description 67
- 229960000521 lufenuron Drugs 0.000 title claims abstract description 67
- 239000005907 Indoxacarb Substances 0.000 title claims abstract description 63
- VBCVPMMZEGZULK-NRFANRHFSA-N indoxacarb Chemical compound C([C@@]1(OC2)C(=O)OC)C3=CC(Cl)=CC=C3C1=NN2C(=O)N(C(=O)OC)C1=CC=C(OC(F)(F)F)C=C1 VBCVPMMZEGZULK-NRFANRHFSA-N 0.000 title claims abstract description 63
- PWPJGUXAGUPAHP-UHFFFAOYSA-N lufenuron Chemical compound C1=C(Cl)C(OC(F)(F)C(C(F)(F)F)F)=CC(Cl)=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F PWPJGUXAGUPAHP-UHFFFAOYSA-N 0.000 title claims abstract description 61
- 239000007788 liquid Substances 0.000 title claims abstract description 44
- 230000002195 synergetic effect Effects 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 239000000654 additive Substances 0.000 title 1
- 230000000996 additive effect Effects 0.000 title 1
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 41
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229940051841 polyoxyethylene ether Drugs 0.000 claims abstract description 32
- 229920000056 polyoxyethylene ether Polymers 0.000 claims abstract description 32
- 239000010632 citronella oil Substances 0.000 claims abstract description 22
- 239000002480 mineral oil Substances 0.000 claims abstract description 22
- 235000010446 mineral oil Nutrition 0.000 claims abstract description 22
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 29
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- 239000002270 dispersing agent Substances 0.000 claims description 18
- 239000000080 wetting agent Substances 0.000 claims description 18
- 239000002518 antifoaming agent Substances 0.000 claims description 17
- 239000003995 emulsifying agent Substances 0.000 claims description 15
- 239000002562 thickening agent Substances 0.000 claims description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000230 xanthan gum Substances 0.000 claims description 12
- 229920001285 xanthan gum Polymers 0.000 claims description 12
- 229940082509 xanthan gum Drugs 0.000 claims description 12
- 235000010493 xanthan gum Nutrition 0.000 claims description 12
- 239000006229 carbon black Substances 0.000 claims description 11
- 239000000725 suspension Substances 0.000 claims description 10
- -1 polysiloxane Polymers 0.000 claims description 6
- 239000012669 liquid formulation Substances 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 125000000129 anionic group Chemical group 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 125000003827 glycol group Chemical group 0.000 claims description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 2
- 239000004530 micro-emulsion Substances 0.000 claims description 2
- 239000002736 nonionic surfactant Substances 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 229920005646 polycarboxylate Polymers 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 229920001451 polypropylene glycol Polymers 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 35
- 230000035699 permeability Effects 0.000 abstract description 20
- 239000000575 pesticide Substances 0.000 abstract description 17
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 37
- 241000238631 Hexapoda Species 0.000 description 23
- 230000000694 effects Effects 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 239000000375 suspending agent Substances 0.000 description 14
- 238000012360 testing method Methods 0.000 description 12
- 238000009736 wetting Methods 0.000 description 11
- 239000008367 deionised water Substances 0.000 description 10
- 229910021641 deionized water Inorganic materials 0.000 description 10
- 230000009467 reduction Effects 0.000 description 10
- CWFOCCVIPCEQCK-UHFFFAOYSA-N chlorfenapyr Chemical compound BrC1=C(C(F)(F)F)N(COCC)C(C=2C=CC(Cl)=CC=2)=C1C#N CWFOCCVIPCEQCK-UHFFFAOYSA-N 0.000 description 9
- 239000012747 synergistic agent Substances 0.000 description 9
- 241000607479 Yersinia pestis Species 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 241000255967 Helicoverpa zea Species 0.000 description 6
- 240000007124 Brassica oleracea Species 0.000 description 4
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 4
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 4
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 4
- 206010059866 Drug resistance Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 241000256247 Spodoptera exigua Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 230000000749 insecticidal effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000000361 pesticidal effect Effects 0.000 description 3
- 244000003416 Asparagus officinalis Species 0.000 description 2
- 235000005340 Asparagus officinalis Nutrition 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000219146 Gossypium Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241000255993 Trichoplusia ni Species 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000035558 fertility Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- QMEQBOSUJUOXMX-UHFFFAOYSA-N 2h-oxadiazine Chemical compound N1OC=CC=N1 QMEQBOSUJUOXMX-UHFFFAOYSA-N 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 239000005893 Diflubenzuron Substances 0.000 description 1
- 240000002024 Gossypium herbaceum Species 0.000 description 1
- 235000004341 Gossypium herbaceum Nutrition 0.000 description 1
- HRYILSDLIGTCOP-UHFFFAOYSA-N N-benzoylurea Chemical compound NC(=O)NC(=O)C1=CC=CC=C1 HRYILSDLIGTCOP-UHFFFAOYSA-N 0.000 description 1
- 241000255969 Pieris brassicae Species 0.000 description 1
- 108010052164 Sodium Channels Proteins 0.000 description 1
- 102000018674 Sodium Channels Human genes 0.000 description 1
- WWBXZKQQXUFSED-UHFFFAOYSA-N [Na].O=C.C1=CC=C2C(S(=O)(=O)OC)=CC=CC2=C1 Chemical compound [Na].O=C.C1=CC=C2C(S(=O)(=O)OC)=CC=CC2=C1 WWBXZKQQXUFSED-UHFFFAOYSA-N 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- QQQYTWIFVNKMRW-UHFFFAOYSA-N diflubenzuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC=C(Cl)C=C1 QQQYTWIFVNKMRW-UHFFFAOYSA-N 0.000 description 1
- 229940019503 diflubenzuron Drugs 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 102220042174 rs141655687 Human genes 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/44—Poaceae or Gramineae [Grass family], e.g. bamboo, lemon grass or citronella grass
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Insects & Arthropods (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticides, and in particular relates to a synergistic auxiliary agent and indoxacarb and lufenuron liquid preparation, wherein the synergistic auxiliary agent comprises citronella oil, mineral oil and isomeric alcohol polyoxyethylene ether, and the weight ratio of the citronella oil to the mineral oil to the isomeric alcohol polyoxyethylene ether is (2-6): 6-10:3-8, the synergistic auxiliary agent is used in indoxacarb and lufenuron liquid preparation, which can obviously reduce the surface tension of the medicament and increase the permeability and the adhesive force of the medicament, thereby playing a synergistic role.
Description
Technical Field
The invention belongs to the technical field of pesticides, and particularly relates to a synergistic auxiliary agent and indoxacarb and lufenuron liquid preparation.
Background
In the process of planting crops, the pesticide is basically separated, the chemical pesticide has quick effect, the occurrence of plant diseases and insect pests can be quickly controlled, and the high yield of crops is ensured. Indoxacarb belongs to oxadiazine pesticides, has a unique action mechanism, and irreversibly blocks sodium channels after being rapidly converted into N-demethoxycarbonyl metabolites in insect bodies, so that insecticidal activity is exerted, and the indoxacarb starts to be registered and used in 1998. Lufenuron belongs to benzoyl urea pesticides, is a chitin synthesis inhibitor, and is first marketed in France in 1993.
The patent CN101485329B applies for the insecticidal pesticide composition of indoxacarb and lufenuron in 2009, and compared with a single agent, the insecticidal pesticide composition has the advantages of improving the control effect, reducing the dosage and expanding the control spectrum. The drug resistance is a problem faced by any pesticide after use, namely indoxacarb and lufenuron are not exceptional, and as indoxacarb and lufenuron are used scientifically for a long time, a plurality of pests generate different degrees of drug resistance to the indoxacarb and lufenuron, so that the pesticide consumption is increased at will to achieve the ideal control effect, the cost of the pesticide is increased, and the environment is polluted. The conventional indoxacarb and lufenuron pesticide has the defects that the pesticide liquid is lost more due to the fact that the surface tension of the pesticide liquid is large and fog drops cannot be effectively wetted, spread and attached on the target leaf surfaces when the conventional indoxacarb and lufenuron pesticide is used, and the pesticide effect is poor.
Disclosure of Invention
In order to improve the control effect of the indoxacarb and lufenuron liquid preparation, delay the drug resistance, reduce the dosage and protect the ecological environment, the invention provides a synergistic auxiliary agent and the indoxacarb and lufenuron liquid preparation, and the synergistic auxiliary agent of the indoxacarb and lufenuron liquid preparation is obtained by compounding citronella oil, mineral oil and isomeric alcohol polyoxyethylene ether, so that the surface tension of the indoxacarb and lufenuron liquid preparation can be obviously reduced, the permeability of the drug is increased, and the drug can be quickly penetrated through insects, thereby playing a synergistic role.
The technical scheme of the invention is as follows:
the indoxacarb lufenuron liquid preparation synergistic auxiliary comprises citronella oil, mineral oil and isomeric alcohol polyoxyethylene ether, wherein the weight ratio of the citronella oil to the mineral oil to the isomeric alcohol polyoxyethylene ether is 2-6:6-10:3-8.
As a specific embodiment, the number of carbon atoms of the isomeric alcohol in the isomeric alcohol polyoxyethylene ether is C9-C12, and the number of EO is 6-8.
Because the length of alkyl chain and EO polymerization degree in the isomeric alcohol polyoxyethylene ether can influence the capability of reducing surface tension of the isomeric alcohol polyoxyethylene ether, the number of carbon atoms of the isomeric alcohol in the isomeric alcohol polyoxyethylene ether is C9-C12, and the number of EO is 6-8.
The indoxacarb lufenuron liquid preparation comprises effective components and auxiliary agents, wherein the auxiliary agents comprise one or more of dispersing agents, wetting agents, emulsifying agents, antifreezing agents, thickening agents and defoaming agents, and the auxiliary agents comprise citronella oil, mineral oil, isomeric alcohol polyoxyethylene ether, and the weight ratio of the citronella oil to the mineral oil to the isomeric alcohol polyoxyethylene ether is (2-6): 6-10:3-8.
The indoxacarb lufenuron liquid preparation comprises effective components and auxiliary agents, wherein the auxiliary agents comprise one or more of dispersing agents, wetting agents, emulsifying agents, antifreezing agents, thickening agents and defoaming agents, and the auxiliary agents comprise citronella oil, mineral oil and isomeric alcohol polyoxyethylene ether, and the weight ratio of the citronella oil to the mineral oil to the isomeric alcohol polyoxyethylene ether is (2-6): 6-10:3-8; the number of carbon atoms of the isomeric alcohol in the isomeric alcohol polyoxyethylene ether is C9-C12, and the number of EO is 6-8.
As a specific embodiment, the content of the synergistic agent is 5-8%.
As a specific embodiment, the content of the effective components indoxacarb and lufenuron is 12-22%.
As a specific embodiment, the liquid formulation is a suspension or microemulsion.
As a specific embodiment, the dispersing agent is one or more of polycarboxylate dispersing agent and macromolecular amphiphilic anionic nonionic surfactant.
As a specific embodiment, the wetting agent is a modified alkylphenol ethoxylate type wetting agent.
As a specific embodiment, the antifoaming agent is a polysiloxane-based antifoaming agent; the thickener is one or two of xanthan gum and white carbon black, and the antifreezing agent is glycol.
As a specific embodiment, the emulsifier is one or more of fatty alcohol polyoxyethylene ether phosphate and polyoxypropylene polyoxyethylene block polymers
The indoxacarb and the lufenuron have the effects of touch killing and stomach poisoning, and the pests can be effectively prevented and controlled only by reducing the surface tension of the medicament, reducing the loss of the medicament, reducing the surface tension of the indoxacarb and lufenuron liquid medicament and improving the permeability of the medicament, so that the medicament is in quick contact with the pests and enters the body. The inventor finally obtains a synergistic auxiliary agent suitable for indoxacarb and lufenuron liquid preparation through repeated experiments, wherein mineral oil can improve the permeability of the preparation, isomeric alcohol polyoxyethylene ether can reduce the surface tension of the preparation, and citronella oil can dissolve the wall of a pest so that the preparation can quickly enter the insect body; the synergistic auxiliary agent combination of three different action mechanisms can obviously reduce the surface tension of the medicament, improve the permeability of the medicament, quickly penetrate through the insect body wall and improve the control effect of the medicament.
The synergistic auxiliary agent is added into the indoxacarb-lufenuron liquid preparation, so that the wetting permeability and the dissolving capacity of the indoxacarb-lufenuron liquid preparation to pest body walls can be increased, the surface tension of the liquid medicine can be reduced, the control effect of the indoxacarb-lufenuron liquid preparation can be obviously improved, the dosage of the medicament can be reduced, and the life cycle of the medicament can be prolonged.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The experimental methods used in the following examples and comparative examples are conventional methods, and the following percentages are weight percentages unless otherwise specified.
Materials, reagents and the like used in the following examples and comparative examples are commercially available unless otherwise specified.
SP-27001 and SP-SC29 used in the following examples and comparative examples were purchased from Jiangsu Optimus chemical engineering Co., ltd; GY-D07 was purchased from Beijing Guangdong Yinong chemical Co., ltd; 860P is purchased from SOLVAY; sag 1522 was purchased from the Michaelsen advanced New Material group; other raw materials are all readily available products on the market.
Example 1:12% indoxacarb lufenuron suspending agent
Indoxacarb, 8%; lufenuron, 4%; dispersant SP-SC29,2%; GY-D07,3%; wetting agent 860P,1%; emulsifying agent, AEO-7P,2%, 1601,4%; defoaming agent Sag 1522,0.3%; ethylene glycol as an antifreezing agent, 4%; thickener xanthan gum, 0.1 percent, white carbon black, 1.5 percent; synergistic auxiliary agent: 1% of citronella oil, 3% of mineral oil and 3% of isomeric alcohol polyoxyethylene ether (C9\EO 8); 63.1 percent of deionized water.
Example 2:12% indoxacarb lufenuron suspending agent
Indoxacarb, 8%; lufenuron, 4%; dispersant SP-SC29,2%, GY-D07,3%; wetting agent 860P,1%; emulsifying agent, AEO-7P,2%, 1601,4%; defoaming agent Sag 1522,0.3%; ethylene glycol as an antifreezing agent, 4%; thickener xanthan gum, 0.1 percent, white carbon black, 1.5 percent; synergistic auxiliary agent: 1% of citronella oil, 4% of mineral oil and 3% of isomeric alcohol polyoxyethylene ether (C11\EO 7); 62.1% of deionized water.
Example 3:12% indoxacarb lufenuron suspending agent
Indoxacarb, 8%; lufenuron, 4%; dispersant SP-SC29,2%, SP-27001,3%; wetting agent 860P,1%; emulsifying agent, AEO-7P,4%, 1601,2%; defoaming agent Sag 1522,0.3%; ethylene glycol as an antifreezing agent, 4%; thickener xanthan gum, 0.1 percent, white carbon black, 1.5 percent; synergistic auxiliary agent: 1.5% of citronella oil, 4.5% of mineral oil and 2% of isomeric alcohol polyoxyethylene ether (C8\EO 6); deionized water, 62.1%.
The preparation method of the 12% indoxacarb-lufenuron suspending agent in the above examples 1-3 specifically comprises the following steps:
(1) Adding water, a dispersing agent, a wetting agent, an emulsifying agent, a synergistic auxiliary agent, a defoaming agent and an antifreezing agent into a reaction kettle according to a proportion, and stirring to uniformly mix the components;
(2) Adding the indoxacarb technical, the lufenuron technical and the thickener into a reaction kettle according to the proportion, stirring and shearing to uniformly mix the materials, thereby obtaining a mixed solution;
(3) And (3) adding the mixed solution obtained in the step (2) into a sand mill for grinding until the particle size D90=5um, and obtaining the 12% indoxacarb and lufenuron suspending agent after finishing grinding.
Comparative example 1:12% indoxacarb lufenuron suspending agent
Indoxacarb, 8%; lufenuron, 4%; dispersant SP-SC29,2%; GY-D07,3%; wetting agent 860P,1%; emulsifying agent, AEO-7P,2%, 1601,4%; defoaming agent Sag 1522,0.3%; ethylene glycol as an antifreezing agent, 4%; thickener xanthan gum, 0.1 percent, white carbon black, 1.5 percent; 70.1% of deionized water.
In comparison with example 1, citronella oil, mineral oil, and isomeric alcohol polyoxyethylene ether were not added in comparative example 1. Comparative example 2:12% indoxacarb lufenuron suspending agent
Comparative example 2 a 12% indoxacarb lufenuron suspension was formulated according to the method provided in patent CN101485329B, the specific formulation being as follows:
indoxacarb, 8%; lufenuron, 4%; sodium methyl naphthalene sulfonate formaldehyde condensate, 10%; xanthan gum, 1%; bentonite, 1%; glycerol, 5%; deionized water, 71%.
The active ingredients, the dispersing agent, the wetting agent, the water and other components are uniformly mixed according to the formula proportion, and the 12% indoxacarb and lufenuron suspending agent is obtained after grinding.
Compared with the example 1, the comparative example 2 is not added with citronella oil, mineral oil and isomeric alcohol polyoxyethylene ether synergistic auxiliary agent, and the auxiliary agent is different.
Comparative example 3:12% indoxacarb lufenuron suspending agent
Indoxacarb, 8%; lufenuron, 4%; dispersant SP-SC29,2%, GY-D07,3%; wetting agent 860P,1%; emulsifying agent, AEO-7P,2%, 1601,4%; defoaming agent Sag 1522,0.3%; ethylene glycol as an antifreezing agent, 4%; thickener xanthan gum, 0.1 percent, white carbon black, 1.5 percent; 1% of synergistic auxiliary agent citronella oil and 3% of mineral oil; 66.1% of deionized water.
In comparison with example 1, comparative example 3 was free of isomeric alcohol polyoxyethylene ether.
Comparative example 4:12% indoxacarb lufenuron suspending agent
Indoxacarb, 8%; lufenuron, 4%; dispersant SP-SC29,2%, GY-D07,3%; wetting agent 860P,1%; emulsifying agent, AEO-7P,2%, 1601,4%; defoaming agent Sag 1522,0.3%; ethylene glycol as an antifreezing agent, 4%; thickener xanthan gum, 0.1 percent, white carbon black, 1.5 percent; 1% of synergistic auxiliary agent citronella oil and 3% of isomeric alcohol polyoxyethylene ether (C9\EO 8); 66.1% of deionized water.
In comparison with example 1, comparative example 4 was free of mineral oil.
Comparative example 5:12% indoxacarb lufenuron suspending agent
Indoxacarb, 8%; lufenuron, 4%; dispersant SP-SC29,2%, GY-D07,3%; wetting agent 860P,1%; emulsifying agent, AEO-7P,2%, 1601,4%; defoaming agent Sag 1522,0.3%; ethylene glycol as an antifreezing agent, 4%; thickener xanthan gum, 0.1 percent, white carbon black, 1.5 percent; 3% of synergistic auxiliary agent mineral oil and 3% of isomeric alcohol polyoxyethylene ether (C9\EO 8); deionized water 64.1%.
In comparison with example 1, comparative example 5 was free of citronella oil.
Comparative example 6:12% chlorfenapyr suspending agent
Chlorfenapyr, 12%; dispersant SP-SC29,2%, GY-D07,3%; wetting agent 860P,1%; emulsifying agent, AEO-7P,2%, 1601,4%; defoaming agent Sag 1522,0.3%; ethylene glycol as an antifreezing agent, 4%; thickener xanthan gum, 0.1 percent, white carbon black, 1.5 percent; 1% of synergistic auxiliary agent citronella oil, 3% of mineral oil and 3% of isomeric alcohol polyoxyethylene ether (C9\EO 8); deionized water, 63.1%.
Comparative example 6 is a different active ingredient chlorfenapyr suspension agent compared with example 1.
Comparative example 7:12% chlorfenapyr suspending agent
Chlorfenapyr, 12%; dispersant SP-SC29,2%, GY-D07,3%; wetting agent 860P,1%; emulsifying agent, AEO-7P,2%, 1601,4%; defoaming agent Sag 1522,0.3%; ethylene glycol as an antifreezing agent, 4%; thickener xanthan gum, 0.1 percent, white carbon black, 1.5 percent; 70.1% of deionized water.
In comparison with example 1, comparative example 6 is a different active ingredient chlorfenapyr suspension and no builder is added.
The pesticidal pesticide compositions of the above comparative example 1 and comparative examples 3 to 7 were prepared according to the preparation methods of the examples to obtain the corresponding dosage forms.
Test
The samples prepared in the examples 1-3 and the comparative examples 1-7 are placed for cold storage at 0+/-2 ℃ for 14 days, hot storage at 54 ℃ for 14 days, the fluidity of the samples is normal, no bottom coagulation or flocculation is caused, and the stability is qualified.
Measuring the interface characteristics of the liquid medicine: surface tension and wet permeability measurements.
The permeability is measured by adopting a pure cotton canvas sheet wetting sedimentation method: (1) 150ml of medicament with the use concentration is prepared in a 200ml beaker, and the mixture is stirred uniformly and the temperature is regulated to be (25+/-1); (2) placing a canvas sheet on a cleaned iron wire ring, carefully displacing the canvas sheet on the leaf surface of a beaker, starting a stopwatch to count the time until the canvas ring is wetted, continuing until the canvas ring just continuously subsides, and counting the time; (3) 3 times of parallel measurement are carried out on each concentration of the sample; the surface tension is measured by a surface tension meter, and is corrected by clear water, and specific data are as follows:
table 1 parameters for measuring the interface of each drug
From the above examples and comparative examples, it can be seen that:
(1) The lower surface tension of examples 1,2, 3, 4, 5 and 6 and the higher surface tension of comparative examples 1,3 and 7 also demonstrate that the addition of the isomeric polyoxyethylene ether can significantly reduce the surface tension of the liquid medicine.
(2) From the results of the surface tension and the wetting permeability of the liquid medicine in the example 1 and the comparative example 1, the synergistic auxiliary agent of the invention is added into the indoxacarb and diflubenzuron preparation, so that the surface tension of the liquid medicine is obviously reduced, and the wetting permeability of the liquid medicine is obviously enhanced.
(3) From the results of the surface tension and the wetting permeability of the liquid medicine in the example 1 and the comparative example 3, the surface tension is obviously reduced and the wetting permeability is also obviously reduced by adding the isomeric alcohol polyoxyethylene ether in the synergistic agent, which also verifies that the surface tension of the liquid medicine has obvious influence on the wetting permeability performance.
(4) From the results of the surface tension and the wetting permeability of the liquid medicine of the example 1 and the comparative example 4, it is known that the mineral oil is added in the synergistic agent of the invention, the permeability of the liquid medicine is obviously enhanced, and the surface tension is reduced to a certain extent.
(5) From the results of the surface tension and the wetting permeability of the liquid medicine in the example 1 and the comparative example 5, the synergistic agent of the invention can increase the permeability of the liquid medicine to a certain extent by adding citronella oil, and reduce the surface tension.
(6) As can be seen from the results of the surface tension and the wetting permeability of the liquid medicine in the comparative examples 6 and 7, the synergistic auxiliary agent of the invention is added into the chlorfenapyr preparation, so that the surface tension of the liquid medicine is obviously reduced, and the wetting permeability of the liquid medicine is obviously enhanced.
Field test
Efficacy test for preventing and controlling cotton bollworms
Test agent: examples 1-3, comparative examples 1-7 and clear water.
The test method comprises the following steps: the test was carried out in a farm in Xinjiang 7 months, the soil texture of the test land was sandy loam, the fertility was moderate, and the test was carried out in the period from the peak incubation period of the cotton bollworm eggs to the initial flourishing period of the low-age larvae. Area of each experimental cell 50m 2 Each treatment was repeated 4 times; the number of larvae on 25 cotton plants is investigated at fixed points per cell by a fixed-point fixed-plant investigation method. The number of insect population was investigated before application, the number of living insects remaining on cotton was investigated after 7d and 15d, and the control effect of each treatment was calculated as the rate of reduction of insect population.
The calculation formula is as follows:
rate of reduction of insect population = (predrug resistance number-postdrug insect resistance number)/(predrug resistance number x 100%)
Correction control = (rate of reduction of insect population in treated group-rate of reduction of insect population in control group)/(rate of reduction of insect population in 1-control group) ×100%
Table 2 results of different examples in field control of bollworms
As can be seen from Table 2, the indoxacarb and lufenuron of examples 1-3 have a control effect on cotton bollworms of 94% or more at 15 days, and the efficacy of examples 1-3 with the synergistic agent is better than that of comparative examples 1-7 under the same mu dosage. From example 1 and comparative example 1, the synergistic agent of the present invention significantly increases the control effect of indoxacarb lufenuron on cotton bollworms. As can be seen from comparative examples 6 and 7, the synergistic agent of the present invention can also significantly increase the efficacy of chlorfenapyr against cotton bollworms. The synergistic auxiliary agent has more obvious synergy on indoxacarb lufenuron.
Field test for preventing cabbage beet armyworm
Test agent: examples 1-3, comparative examples 1-7 and clear water.
The test method comprises the following steps: the test is carried out on vegetable bases in Boxing county of Shandong province, the soil texture of the test is loam, the fertility is medium, the pesticide spraying is carried out in the initial stage of cabbage beet armyworms, and the area of each experimental district is 20m 2 Each treatment was repeated 4 times. Marking cabbage with beet armyworms, investigating 5 points in each district, investigating 2 plants in each point, and recording the number of living insects; the number of the insect population was investigated before the application, the number of living insects remaining on the test was investigated for 7d and 15d after the application, and the control effect of each treatment was calculated as the rate of reduction of the insect population.
The calculation formula is as follows:
rate of reduction of insect population = (predrug resistance number-postdrug insect resistance number)/(predrug resistance number x 100%)
Correction control = (rate of reduction of insect population in treated group-rate of reduction of insect population in control group)/(rate of reduction of insect population in 1-control group) ×100%
TABLE 3 results of field control of asparagus caterpillar for different examples
As can be seen from Table 3, the indoxacarb and lufenuron of examples 1-3 have a control effect on cabbage looper of over 95% at 15 days, and the control effect of the examples is obviously improved compared with that of the comparative examples; under the condition of the same dosage per mu, the pesticide effect of the examples 1-3 added with the synergistic auxiliary agent is better than that of the comparative examples 1-7 on cabbage asparagus caterpillar. From example 1 and comparative example 1, the synergistic agent of the present invention greatly increases the imitation of cabbage looper by indoxacarb lufenuron. As can be seen from comparative examples 6 and 7, the synergistic agent of the present invention can also significantly increase the imitation of cabbage caterpillar by chlorfenapyr. The synergistic auxiliary agent has more obvious synergy on the indoxacarb and the lufenuron.
In conclusion, the synergistic auxiliary agent and the indoxacarb-lufenuron liquid preparation provided by the invention adopt the synergistic auxiliary agent combination of three different action mechanisms, so that the surface tension of the medicament can be obviously reduced, the permeability of the medicament is improved, and the medicament control effect is effectively improved; after the synergistic auxiliary agent is added into the indoxacarb and lufenuron liquid preparation, the control effect of the indoxacarb and lufenuron liquid preparation is obviously improved, the synergistic auxiliary agent can effectively reduce the dosage and the times of field application, reduce the risk of drug resistance of diseases and insect pests caused by long-term application of the drug, and has important significance for field comprehensive control.
Claims (10)
1. The indoxacarb lufenuron liquid preparation synergistic auxiliary agent is characterized by comprising citronella oil, mineral oil, isomeric alcohol polyoxyethylene ether, wherein the weight ratio of the citronella oil to the mineral oil to the isomeric alcohol polyoxyethylene ether is 2-6:6-10:3-8.
2. The indoxacarb lufenuron liquid preparation synergistic assistant according to claim 1, wherein the number of carbon atoms of the isomeric alcohol in the isomeric alcohol polyoxyethylene ether is C9-C12, and the number of EO is 6-8.
3. The indoxacarb lufenuron liquid preparation comprises an effective component and an auxiliary agent, wherein the auxiliary agent comprises one or more of a dispersing agent, a wetting agent, an emulsifying agent, an antifreezing agent, a thickening agent and a defoaming agent, and is characterized by further comprising a synergistic auxiliary agent, and the synergistic auxiliary agent is the synergistic auxiliary agent described in claim 1 or 2.
4. The indoxacarb lufenuron liquid formulation according to claim 3, wherein the content of the co-agent is 5-8%.
5. The indoxacarb-lufenuron suspension liquid preparation according to claim 3, wherein the content of the active ingredients indoxacarb and lufenuron is 12-22%.
6. A indoxacarb lufenuron suspension liquid formulation according to claim 3, characterized in that the liquid formulation is a suspension or a microemulsion.
7. The indoxacarb lufenuron suspension liquid preparation according to claim 3, wherein the dispersing agent is one or more of polycarboxylate dispersing agents and macromolecular amphiphilic anionic nonionic surfactants.
8. The indoxacarb lufenuron suspension liquid preparation according to claim 3, wherein the wetting agent is a modified alkylphenol polyoxyethylene ether type wetting agent.
9. The indoxacarb lufenuron suspension liquid formulation according to claim 3, wherein the antifoaming agent is a polysiloxane-based antifoaming agent; the thickener is one or two of xanthan gum and white carbon black, and the antifreezing agent is glycol.
10. The indoxacarb lufenuron suspension liquid preparation according to claim 3, wherein the emulsifier is one or more of fatty alcohol polyoxyethylene ether phosphate and polyoxypropylene polyoxyethylene block polymers.
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| WO2024178357A1 (en) * | 2023-02-23 | 2024-08-29 | Control Solutions, Inc. | Pour-on formulation for controlling pests in animals |
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