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CN115845009A - Navel moxibustion medicine powder for treating spleen deficiency diarrhea and application and use method thereof - Google Patents

Navel moxibustion medicine powder for treating spleen deficiency diarrhea and application and use method thereof Download PDF

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Publication number
CN115845009A
CN115845009A CN202211007911.8A CN202211007911A CN115845009A CN 115845009 A CN115845009 A CN 115845009A CN 202211007911 A CN202211007911 A CN 202211007911A CN 115845009 A CN115845009 A CN 115845009A
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parts
powder
navel
diarrhea
spleen
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CN115845009B (en
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李素云
王明航
谢洋
梁国玲
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First Affiliated Hospital of Henan University of TCM
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First Affiliated Hospital of Henan University of TCM
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Abstract

The invention provides navel moxibustion medicine powder for treating spleen deficiency diarrhea, which comprises the following raw materials in parts by weight: 10-14 parts of astragalus membranaceus, 6-10 parts of codonopsis pilosula, 10-14 parts of bighead atractylodes rhizome, 4-8 parts of poria cocos, 2-6 parts of Chinese yam, 2-6 parts of honey-fried licorice root, 4-8 parts of pinellia ternate, 2-6 parts of dried orange peel, 4-8 parts of rhizoma cyperi, 1-3 parts of elecampane, 2-6 parts of coptis chinensis, 2-6 parts of fructus evodiae, 2-6 parts of fructus amomi, 4-8 parts of angelica sinensis and 4-8 parts of radix paeoniae alba. The prescription provided by the invention is reasonable and balanced in preparation, all raw materials are synergistic to play a role, qi is tonified, spleen is strengthened, and the traditional Chinese medicine has the effects of regulating the middle warmer and stopping dysentery, has no toxic or side effect, has the advantages of good curative effect, quick response, high cure rate, relapse prevention and the like in the aspect of treating diarrhea due to spleen deficiency, and is wider in application range, quick in medicine absorption and more remarkable in curative effect compared with the traditional oral or injection treatment method.

Description

Navel moxibustion medicine powder for treating spleen deficiency diarrhea and application and use method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to navel moxibustion medicine powder for treating spleen deficiency diarrhea and an application and a using method thereof.
Background
Diarrhea due to spleen deficiency is a common digestive tract disease. Diarrhea with loose stool, protracted and repeated diarrhea, indigestion, reduced diet, discomfort in the epigastrium after eating, increased frequency of stool after eating a little greasy food, scanty urine, sallow complexion, heavy body, fullness in the chest, mental fatigue, lassitude, pale tongue with white coating, and thready and weak pulse. Diarrhea due to spleen deficiency refers to diarrhea caused by spleen qi deficiency, cold or cool food after illness, improper diet, or spleen injury due to overstrain. The cause mechanism of diarrhea due to spleen deficiency is caused by water dampness blocking in stomach and intestine, spleen deficiency failing to transport and water failing to produce and dampness entering intestinal tract. The infantile spleen deficiency diarrhea is usually caused by weakness of body or deficiency of primordial qi due to chronic disease, and is caused by deficiency of spleen-stomach qi, weakness of transportation and transformation, morning diarrhea due to spleen-kidney yang deficiency, and chronic disease and kidney. If the treatment is not carried out in time, not only the physical and psychological health of the patient is seriously affected, but also the trouble is brought to the life, the work and the study of the patient. At present, the modern medicine clinically treats the diarrhea due to spleen deficiency by adopting antidiarrheal drugs, spasmolytic analgesics, intestinal probiotics, antibiotics and other drugs, has quick response, but is easy to cause the dependence of patients on the drugs, also has side effects on the body health of the patients, and the illness state is easy to repeat after the drugs are stopped.
Disclosure of Invention
In view of the above, the technical problem to be solved by the invention is to provide navel moxibustion powder for treating spleen deficiency diarrhea, and application and a use method thereof.
The invention provides navel moxibustion medicine powder for treating spleen deficiency diarrhea, which comprises the following raw materials in parts by weight: 10-14 parts of astragalus membranaceus, 6-10 parts of codonopsis pilosula, 10-14 parts of bighead atractylodes rhizome, 4-8 parts of poria cocos, 2-6 parts of Chinese yam, 2-6 parts of honey-fried licorice root, 4-8 parts of pinellia ternate, 2-6 parts of dried orange peel, 4-8 parts of rhizoma cyperi, 1-3 parts of elecampane, 2-6 parts of coptis chinensis, 2-6 parts of fructus evodiae, 2-6 parts of round cardamon seed, 4-8 parts of angelica sinensis and 4-8 parts of white peony root.
Preferably, the raw materials comprise the following components in parts by weight:
10 parts of astragalus membranaceus, 6 parts of codonopsis pilosula, 10 parts of bighead atractylodes rhizome, 4 parts of poria cocos, 2 parts of Chinese yam, 2 parts of honey-fried licorice root, 4 parts of pinellia ternate, 2 parts of pericarpium citri reticulatae, 4 parts of rhizoma cyperi, 1 part of elecampane, 2 parts of coptis chinensis, 2 parts of fructus evodiae, 2 parts of fructus amomi, 4 parts of angelica sinensis and 4 parts of radix paeoniae alba.
Preferably, the raw materials comprise the following components in parts by weight:
12 parts of astragalus membranaceus, 8 parts of codonopsis pilosula, 12 parts of bighead atractylodes rhizome, 6 parts of poria cocos, 4 parts of Chinese yam, 4 parts of honey-fried licorice root, 6 parts of pinellia ternate, 4 parts of pericarpium citri reticulatae, 6 parts of rhizoma cyperi, 2 parts of elecampane, 4 parts of coptis chinensis, 4 parts of fructus evodiae, 4 parts of fructus amomi, 6 parts of angelica sinensis and 6 parts of radix paeoniae alba.
Preferably, the raw materials comprise the following components in parts by weight:
14 parts of astragalus membranaceus, 10 parts of codonopsis pilosula, 14 parts of bighead atractylodes rhizome, 8 parts of poria cocos, 6 parts of Chinese yam, 6 parts of honey-fried licorice root, 8 parts of pinellia ternate, 6 parts of pericarpium citri reticulatae, 8 parts of rhizoma cyperi, 3 parts of elecampane, 6 parts of coptis chinensis, 6 parts of fructus evodiae, 6 parts of fructus amomi, 8 parts of angelica sinensis and 8 parts of radix paeoniae alba.
The invention also provides application of the navel moxibustion medicine powder in preparing a medicine for treating diarrhea due to spleen deficiency.
Preferably, the medicament is in a dosage form selected from navel moxibustion powder.
Preferably, the preparation method of the navel moxibustion powder comprises the following steps:
mixing radix astragali, radix Codonopsis, atractylodis rhizoma, poria, rhizoma Dioscoreae, radix Glycyrrhizae Preparata, rhizoma Pinelliae, pericarpium Citri Tangerinae, rhizoma Cyperi, radix aucklandiae, coptidis rhizoma, fructus evodiae, fructus Amomi rotundus, radix Angelicae sinensis and radix Paeoniae alba, drying, and grinding into powder to obtain navel moxibustion medicinal powder.
The invention also provides a use method of the navel moxibustion powder, which comprises the following steps:
sticking the punctured ginger slices on the navel part of a human body, standing, spreading the navel moxibustion medicine powder on the ginger slices, igniting the navel moxibustion medicine powder, timely taking down the ginger slices when the navel part feels burning pain, and repeating the operation for 4-5 times after the burning pain disappears.
Preferably, the thickness of the ginger slices is 4-5mm, and the number of the pricked holes on the ginger slices is 8-10;
the punctured ginger slices are stuck to the navel part of a human body and are kept standing for 8-10 min.
Preferably, the mass of the navel moxibustion medicine powder which is evenly spread on the ginger slices is 8-10 g of navel moxibustion medicine powder per 4 square centimeters of ginger slices.
Compared with the prior art, the invention provides navel moxibustion medicine powder for treating spleen deficiency diarrhea, which comprises the following raw materials in parts by weight: 10-14 parts of astragalus membranaceus, 6-10 parts of codonopsis pilosula, 10-14 parts of bighead atractylodes rhizome, 4-8 parts of poria cocos, 2-6 parts of Chinese yam, 2-6 parts of honey-fried licorice root, 4-8 parts of pinellia ternate, 2-6 parts of dried orange peel, 4-8 parts of rhizoma cyperi, 1-3 parts of elecampane, 2-6 parts of coptis chinensis, 2-6 parts of fructus evodiae, 2-6 parts of fructus amomi, 4-8 parts of angelica sinensis and 4-8 parts of radix paeoniae alba.
The prescription provided by the invention is reasonable and balanced in preparation, all raw materials play a role in a synergistic manner, the qi is tonified, the spleen is strengthened, the stomach is harmonized, the dysentery is stopped, no toxic or side effect exists, and the traditional Chinese medicine has the advantages of good curative effect, quick response, high cure rate, relapse prevention and the like in the aspect of treating the diarrhea due to spleen deficiency.
Detailed Description
The invention provides navel moxibustion medicine powder for treating spleen deficiency diarrhea, which comprises the following raw materials in parts by weight: 10-14 parts of astragalus membranaceus, 6-10 parts of codonopsis pilosula, 10-14 parts of bighead atractylodes rhizome, 4-8 parts of poria cocos, 2-6 parts of Chinese yam, 2-6 parts of honey-fried licorice root, 4-8 parts of pinellia ternate, 2-6 parts of dried orange peel, 4-8 parts of rhizoma cyperi, 1-3 parts of elecampane, 2-6 parts of coptis chinensis, 2-6 parts of fructus evodiae, 2-6 parts of fructus amomi, 4-8 parts of angelica sinensis and 4-8 parts of radix paeoniae alba.
The navel moxibustion medicinal powder for treating spleen deficiency diarrhea provided by the invention comprises 10-14 parts of astragalus, preferably 10, 11, 12, 13 and 14, or any value between 10-14 parts. In the present invention, astragalus: sweet in nature and taste, slightly warm. Meridian tropism means lung, spleen, liver and kidney meridians entered. The functions are mainly used for tonifying qi, consolidating exterior, promoting urination, expelling toxin, expelling pus, healing sore and promoting granulation. Can be used for treating deficiency of qi, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, metrorrhagia, exterior deficiency, spontaneous perspiration, qi deficiency, edema, carbuncle, cellulitis, intractable ulcer, blood deficiency, debility with yellowish complexion, internal heat, and diabetes.
The navel moxibustion medicine powder for treating spleen deficiency and diarrhea provided by the invention further comprises 6-10 parts of codonopsis pilosula, preferably 6, 7, 8, 9 and 10, or any value between 6 and 10. In the present invention, codonopsis pilosula: sweet in nature and taste, mild in nature. It enters spleen and lung meridians. Tonify middle warmer, replenish qi, and promote fluid production. It can be used for treating weakness of spleen and stomach, deficiency of both qi and blood, asthenia, anorexia, thirst, and chronic diarrhea.
The navel moxibustion medicinal powder for treating spleen deficiency diarrhea provided by the invention also comprises 10-14 parts of bighead atractylodes rhizome, preferably 10, 11, 12, 13 and 14, or any value between 10-14 parts. In the present invention, the white atractylodes rhizome: bitter and sweet in property and warm in nature. It enters spleen and stomach meridians. The functions are mainly to strengthen the spleen and replenish qi, eliminate dampness and promote diuresis and stop sweating. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, and spontaneous perspiration.
The navel moxibustion medicinal powder for treating spleen deficiency diarrhea provided by the invention also comprises 4-8 parts of poria cocos, preferably 4, 5, 6, 7, 8, or any value between 4-8 parts. In the present invention, poria: sweet, bland and mild in nature and taste. It enters heart, lung, spleen and kidney meridians. The functions are mainly used for promoting diuresis and excreting dampness, strengthening spleen and calming heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
The navel moxibustion medicine powder for treating spleen deficiency and diarrhea provided by the invention also comprises 2-6 parts of Chinese yam, preferably 2, 3, 4, 5, 6, or any value between 2-6 parts. In the present invention, yam: sweet in nature and taste, mild. It enters spleen, lung and kidney meridians. The functions are mainly used for tonifying spleen and nourishing stomach, promoting the production of body fluid and benefiting lung, and tonifying kidney and arresting seminal emission. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, spermatorrhea, leukorrhagia, frequent micturition, and diabetes due to deficiency heat.
The navel moxibustion medicine powder for treating spleen deficiency and diarrhea provided by the invention further comprises 2-6 parts of honey-fried licorice root, preferably 2, 3, 4, 5, 6, or any value between 2-6 parts. In the invention, honey-fried licorice root: sweet in nature and taste and mild in nature. It enters heart, lung, spleen and stomach meridians. The functions are mainly used for tonifying spleen and stomach, and tonifying qi and recovering pulse. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, and intermittent pulse.
The navel moxibustion medicinal powder for treating spleen deficiency diarrhea provided by the invention also comprises 4-8 parts of pinellia ternate, preferably 4, 5, 6, 7, 8, or any value between 4-8 parts. In the present invention, pinellia ternate: pungent, warm and toxic in nature and flavor. Enter spleen and stomach meridians. The functional indications are as follows: dry dampness and resolve phlegm, check adverse rise of qi and arrest vomiting, relieve stuffiness and dissipate nodulation. Can be used for treating cough with asthma due to excessive phlegm, dizziness and palpitation due to phlegm and fluid retention, dizziness due to wind-phlegm, headache due to phlegm syncope, emesis, regurgitation, chest and gastric fullness, and globus hystericus; unprocessed for treating abscess and phlegm nodule.
The navel moxibustion medicine powder for treating spleen deficiency and diarrhea provided by the invention further comprises 2-6 parts of dried orange peel, preferably 2, 3, 4, 5, 6 or any value between 2-6 parts. In the present invention, dried orange peel: warm in nature, pungent and bitter in flavor. Entering lung and spleen meridians; has effects of warming stomach, dispelling cold, regulating qi-flowing and invigorating spleen.
The navel moxibustion medicinal powder for treating spleen deficiency and diarrhea also comprises 4-8 parts of rhizoma cyperi, preferably 4, 5, 6, 7 and 8 or any value between 4 and 8 parts. In the present invention, cyperus rotundus: the nature and taste of Xin Weigu are sweet and neutral. Enter liver and triple energizer meridians. The functions are mainly used for regulating qi, resolving stagnation, relieving pain and regulating menstruation. It is indicated for incoordination between liver and stomach, qi stagnation, distending pain in chest, abdomen, hypochondrium, phlegm and fluid.
The navel moxibustion medicine powder for treating spleen deficiency and diarrhea provided by the invention further comprises 1-3 parts of elecampane, preferably 1, 1.5, 2, 2.5 and 3, or any value between 1-3 parts. In the present invention, aucklandia root: pungent, bitter and warm in nature. It enters spleen, stomach, large intestine, triple energizer and gallbladder meridians. The functions are mainly to promote the circulation of qi, relieve pain, invigorate the spleen and promote digestion. Can be used for treating chest and abdominal distention and pain, dysentery, tenesmus, dyspepsia, and anorexia.
The navel moxibustion medicine powder for treating spleen deficiency and diarrhea provided by the invention also comprises 2-6 parts of coptis chinensis, preferably 2, 3, 4, 5, 6 or any value between 2-6 parts. In the present invention, coptis: it is bitter and cold in nature and enters heart, liver, stomach and large intestine meridians. Has the effects of clearing heat, eliminating dampness, purging pathogenic fire and removing toxic substances; can be used for treating gastrointestinal damp-heat dysentery emesis.
The navel moxibustion medicine powder for treating spleen deficiency and diarrhea also comprises 2-6 parts of fructus evodiae, preferably 2, 3, 4, 5, 6 or any value between 2-6 parts. In the present invention, evodia: pungent, bitter and hot in nature. It enters liver, spleen, stomach and kidney meridians. The functions are mainly used for dispelling cold and relieving pain, lowering adverse qi and arresting vomiting, and supporting yang and stopping diarrhea. Can be used for treating syncope headache, hernia of cold, abdominal pain, tinea pedis due to cold dampness, abdominal pain during menstruation, abdominal pain, emesis, acid regurgitation, and diarrhea before dawn.
The navel moxibustion medicine powder for treating spleen deficiency and diarrhea provided by the invention also comprises 2-6 parts of round cardamom seed, preferably 2, 3, 4, 5, 6 or any value between 2-6 parts. In the present invention, cardamon seed: pungent and warm in nature and flavor. Enter lung and spleen meridians. The functions are mainly to promote the circulation of qi, warm the stomach, promote digestion and relieve the epigastric distention. It is used to treat qi stagnation, food stagnation, chest distress, abdominal distention, belching, dysphagia, vomiting, regurgitation, and malaria.
The navel moxibustion medicinal powder for treating spleen deficiency diarrhea provided by the invention also comprises 4-8 parts of angelica, preferably 4, 5, 6, 7, 8, or any value between 4-8 parts. In the present invention, angelica: sweet, pungent and warm in nature. It enters liver, heart and spleen meridians. The functions of the medicine are mainly replenishing blood and activating blood, regulating menstruation and relieving pain, and relaxing bowel. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease.
The navel moxibustion medicinal powder for treating spleen deficiency diarrhea provided by the invention also comprises 4-8 parts of white paeony root, preferably 4, 5, 6, 7, 8 or any value between 4-8 parts. In the present invention, white peony root: bitter and sour in nature and slightly cold in nature. It enters liver and spleen meridians. The functions are mainly used for calming the liver, relieving pain, nourishing blood, regulating menstruation, astringing yin and arresting sweating. Can be used for treating headache, vertigo, hypochondriac pain, abdominal pain, limb spasm and pain, blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, and night sweat.
In some embodiments of the invention, the navel moxibustion medicine powder for treating spleen deficiency diarrhea comprises the following raw materials in parts by weight:
10 parts of astragalus membranaceus, 6 parts of codonopsis pilosula, 10 parts of bighead atractylodes rhizome, 4 parts of poria cocos, 2 parts of Chinese yam, 2 parts of honey-fried licorice root, 4 parts of pinellia ternate, 2 parts of pericarpium citri reticulatae, 4 parts of rhizoma cyperi, 1 part of elecampane, 2 parts of coptis chinensis, 2 parts of fructus evodiae, 2 parts of fructus amomi, 4 parts of angelica sinensis and 4 parts of radix paeoniae alba.
In some embodiments of the invention, the navel moxibustion medicine powder for treating spleen deficiency diarrhea comprises the following raw materials in parts by weight:
12 parts of astragalus membranaceus, 8 parts of codonopsis pilosula, 12 parts of bighead atractylodes rhizome, 6 parts of poria cocos, 4 parts of Chinese yam, 4 parts of honey-fried licorice root, 6 parts of pinellia ternate, 4 parts of pericarpium citri reticulatae, 6 parts of rhizoma cyperi, 2 parts of elecampane, 4 parts of coptis chinensis, 4 parts of fructus evodiae, 4 parts of fructus amomi, 6 parts of angelica sinensis and 6 parts of radix paeoniae alba.
In some embodiments of the invention, the navel moxibustion medicine powder for treating spleen deficiency diarrhea comprises the following raw materials in parts by weight:
14 parts of astragalus membranaceus, 10 parts of codonopsis pilosula, 14 parts of bighead atractylodes rhizome, 8 parts of poria cocos, 6 parts of Chinese yam, 6 parts of honey-fried licorice root, 8 parts of pinellia ternate, 6 parts of pericarpium citri reticulatae, 8 parts of rhizoma cyperi, 3 parts of elecampane, 6 parts of coptis chinensis, 6 parts of fructus evodiae, 6 parts of fructus amomi, 8 parts of angelica sinensis and 8 parts of radix paeoniae alba.
The invention also provides application of the navel moxibustion medicine powder in preparing a medicine for treating diarrhea due to spleen deficiency. Wherein the medicament is in a dosage form selected from navel moxibustion powder.
In the invention, the preparation method of the navel moxibustion powder comprises the following steps:
mixing radix astragali, radix Codonopsis, atractylodis rhizoma, poria, rhizoma Dioscoreae, radix Glycyrrhizae Preparata, rhizoma Pinelliae, pericarpium Citri Tangerinae, rhizoma Cyperi, radix aucklandiae, coptidis rhizoma, fructus evodiae, fructus Amomi rotundus, radix Angelicae sinensis and radix Paeoniae alba, drying, and grinding into powder to obtain navel moxibustion powder.
Wherein the above Chinese medicinal materials can be respectively dried, pulverized and mixed, or mixed, dried, and ground into powder. Wherein, after being crushed, the traditional Chinese medicine powder is sieved by a sieve with 80 to 100 meshes to obtain the navel moxibustion medicine powder.
The invention also provides a using method of the navel moxibustion medicine powder, which comprises the following steps:
sticking the punctured ginger slices on the navel part of a human body, standing, spreading the navel moxibustion medicine powder on the ginger slices, igniting the navel moxibustion medicine powder, timely taking down the ginger slices when the navel part feels burning pain, and repeating the operation for 4-5 times after the burning pain disappears.
Wherein the thickness of the ginger slices is 4-5mm, and the number of the pricked holes on the ginger slices is 8-10;
the punctured ginger slices are stuck to the navel part of a human body and are kept standing for 8-10 min.
The mass of the navel moxibustion medicine powder which is evenly spread on the ginger slices is 8-10 g of navel moxibustion medicine powder per 4 square centimeters of ginger slices.
Before umbilical moxibustion, the navel is cleaned by using 75% of medical alcohol or 0.5% -1% of iodophor cotton balls according to a conventional disinfection method for disinfection.
In the medicinal powder formula, large doses of astragalus and bighead atractylodes rhizome are used as monarch drugs, the astragalus is slightly warm in smell, sweet and nontoxic in taste, and has the natural and peaceful local flavor, and enters the foot Taiyin spleen channel Ben Cao Jing Jie (materia Medica); wang Haogu, which: huang Qi is a Chinese medicine for tonifying spleen and stomach, so it is specially designed for tonifying spleen qi. Bighead atractylodes rhizome, bitter in taste, sweet and warm in flavor, bitter in flavor and dampness eliminating, is recorded in Huangdi's classic of medicine, plain questions: the spleen is bitter and damp, and if it is eaten in an urgent way, it will be bitter and dry, sweet and tonify spleen, mild and middle energizer, so it is the key herb of spleen's Lei Gong processing Yao xing Jie (explanation of Lei Gong processing Yao Shi); changsha Yao Jie (medicine for relieving Changsha) means that it can raise the clear yang and dispel food, so it can be used by doctors to discharge; for diarrhea, the pill and powder is superior to the decoction in Ben Cao Bei Yao (the preparation of materia Medica). Both of them can tonify qi and invigorate spleen, and they are not compatible with other herbs. The codonopsis pilosula, the poria cocos and the Chinese yam are ministerial drugs, wherein the codonopsis pilosula is capable of tonifying middle-jiao, benefiting qi and promoting the production of body fluid, treating chronic diarrhea in the traditional Chinese medicine dictionary, and is called to be capable of treating gastrointestinal intercooling through ceramic, long-flowing and landscape; poria cocos, sweet and warm in flavor, has the effects of tonifying spleen and yang, removing dampness by inducing diuresis to promote defecation, and Huang Yuanyu is a god product for stranguria, urination and diuresis; yam, sweet and warm in flavor, can strengthen spleen qi, stop enuresis and purge, and remove dysentery (Lei Gong processing Yao Ji Yi Xue Jie); the three components are combined together, and the main effects are to assist the monarch drug to treat spleen deficiency and to strengthen and protect middle-jiao to move spleen qi. The pinellia tuber, the dried orange peel, the nutgrass galingale rhizome, the costustoot, the round cardamom seed and the evodia rutaecarpa are mutually reinforced and matched as adjuvant medicaments to regulate qi movement and assist prevention and obtain good effects of monarch medicaments and minister medicaments. Wherein the tangerine peel is pungent, bitter and warm in taste and can remove qi stagnation to purge Yu Man, the tonic astringent can be used for assisting the tangerine peel to promote qi, the pinellia tuber with pungent and warm properties can be used for removing dampness and reducing phlegm, and the spleen and stomach can be greatly harmonized with the Lei Gong processing Yao Jie (materia medica Medica); the compatibility of the ingredients is that the accessory flavor is mild in smell, pungent in flavor, capable of dispersing, slightly bitter in flavor and slightly sweet in flavor, can be used for treating cholera, vomiting and diarrhea, can be used for treating new diseases caused by aging, and all books are cloudy and can tonify qi; matching with pungent and bitter radix aucklandiae to sooth liver, harmonize spleen and dredge stagnation of large intestine; cardamom seed, pungent in flavor and warm in nature, is used together with Wu Zhu Yu to warm the middle-jiao and lower-jiao to treat cold syndrome. Coptis root, rhizoma Coptidis, as an adjuvant drug, is bitter and cold in taste, and has the combining action of tonifying the intestines and stomach to prevent the pungent and warm properties of other drugs from being too excessive and slightly decreasing the qi. The angelica and the white peony root are guiding drugs, and are compatible with each other, so as to achieve the effects of regulating blood and qi, tonifying yin and blood, and assisting spleen to circulate and control blood, and the white peony root is sour in taste and can be collected as a channel-moving drug for foot taiyin, and can be used for treating abdominal pain due to spleen deficiency after diarrhea and dysentery; prepared licorice root, radix Glycyrrhizae Praeparata, is used as a guiding drug, and is used in this formula to regulate the effects of the other drugs in the recipe, and to tonify deficiency of the middle-jiao and spleen. The prescription has reasonable and balanced configuration, all raw materials play a role in synergy, the qi is tonified, the spleen is strengthened, the diarrhea is neutralized and stopped, no toxic or side effect exists, the traditional Chinese medicine has the advantages of good curative effect, quick response, high cure rate, relapse prevention and the like in the aspect of treating the diarrhea due to spleen deficiency, and compared with the traditional oral or injection treatment method, the navel moxibustion therapy adopted by the invention has wider application range, quick medicine absorption and more obvious curative effect.
For further understanding of the present invention, the umbilical moxibustion powder for treating diarrhea due to spleen deficiency and the application and usage thereof provided by the present invention are described below with reference to the following examples, and the scope of the present invention is not limited by the following examples.
Example 1:
in the specific implementation of the invention, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 10 parts of astragalus membranaceus, 6 parts of codonopsis pilosula, 10 parts of bighead atractylodes rhizome, 4 parts of poria cocos, 2 parts of Chinese yam, 2 parts of honey-fried licorice root, 4 parts of pinellia ternate, 2 parts of pericarpium citri reticulatae, 4 parts of rhizoma cyperi, 1 part of elecampane, 2 parts of coptis chinensis, 2 parts of fructus evodiae, 2 parts of fructus amomi, 4 parts of angelica sinensis and 4 parts of radix paeoniae alba
Example 2:
in the specific implementation of the invention, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 12 parts of astragalus membranaceus, 8 parts of codonopsis pilosula, 12 parts of bighead atractylodes rhizome, 6 parts of poria cocos, 4 parts of Chinese yam, 4 parts of honey-fried licorice root, 6 parts of pinellia ternate, 4 parts of pericarpium citri reticulatae, 6 parts of rhizoma cyperi, 2 parts of elecampane, 4 parts of coptis chinensis, 4 parts of fructus evodiae, 4 parts of fructus amomi rotundus, 6 parts of angelica sinensis and 6 parts of radix paeoniae alba
Example 3:
in the specific implementation of the invention, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 14 parts of astragalus, 10 parts of codonopsis pilosula, 14 parts of bighead atractylodes rhizome, 8 parts of poria cocos, 6 parts of Chinese yam, 6 parts of honey-fried licorice root, 8 parts of pinellia ternate, 6 parts of dried orange peel, 8 parts of rhizoma cyperi, 3 parts of elecampane, 6 parts of coptis chinensis, 6 parts of fructus evodiae, 6 parts of fructus amomi, 8 parts of angelica sinensis and 8 parts of radix paeoniae alba
Comparative example 1:
weighing raw material medicines of 20 parts of codonopsis pilosula, 20 parts of bighead atractylodes rhizome, 15 parts of maize, 15 parts of lotus seed, 10 parts of coix seed, 30 parts of astragalus, 15 parts of dried orange peel, 15 parts of honey-fried licorice root, 20 parts of dark plum and 20 parts of myrobalan, respectively preparing decoction pieces, carrying out stewing sterilization for 30-60 minutes by using an autoclave, and airing to obtain sterile raw materials; adding crystal sugar, and mixing to obtain the final product.
Comparative example 2:
the dosage of the Chinese angelica, the white paeony root, the costustoot and the nutgrass galingale rhizome is reduced by half, and the Chinese medicinal preparation is specifically as follows: 12 parts of astragalus membranaceus, 8 parts of codonopsis pilosula, 12 parts of bighead atractylodes rhizome, 6 parts of poria cocos, 4 parts of Chinese yam, 4 parts of honey-fried licorice root, 6 parts of pinellia ternate, 4 parts of pericarpium citri reticulatae, 3 parts of rhizoma cyperi, 1 part of elecampane, 4 parts of coptis chinensis, 4 parts of fructus evodiae and 4 parts of fructus amomi.
Preparation methods of examples 1 to 3 and comparative example 2:
preparing powder: taking the traditional Chinese medicines in parts by weight; drying the obtained medicinal materials, mixing uniformly, grinding into powder, and sieving with 80-100 mesh sieve to obtain traditional Chinese medicine powder.
The usage and dosage are as follows: (1) cutting rhizoma Zingiberis recens into slices with thickness of 4-5mm, and binding the slices with 8-10 small holes; (2) wiping and cleaning the navel part by using 75% of medical alcohol or 0.5% -1% of iodophor cotton balls according to a conventional disinfection method, and then sticking the punctured ginger slices on the navel of a human body for standing for 8-10min; (3) spreading the medicinal powder on rhizoma Zingiberis recens slice at a dosage of 9g navel moxibustion powder/4 cm square rhizoma Zingiberis recens slice, igniting, taking down timely when the body feels burning pain, and repeating the operation for 4-5 times after the burning pain disappears.
Safety evaluation
Monitoring the adverse reaction condition of the patient in the medication process, and immediately stopping the medication process if more than three serious adverse reactions occur.
It was observed that 500 patients did not develop severe adverse events during the administration period, and the incidence of tertiary adverse events was 0 in each example and comparative example. The statistical results are shown in the following table.
TABLE 1 evaluation of safety
Figure RE-GDA0003996080560000081
Toxicity test
20 adult female mice and adult male mice with equivalent body weights are selected and divided into a control group and an administration group, 20 mice in each group are fed with the medicines for 1 time every day, the physical conditions, food intake, water intake and body weight of each mouse are recorded every day, the experiment lasts for six months, compared with the control group, the physical conditions, food intake, water intake and body weight increase of the mice in the administration group are normal, and the mice do not suffer from diseases or die. The medicine powder has good safety and no toxic or side effect.
Test examples
The invention has obvious effect on the aspect of treating the spleen deficiency diarrhea, and in order to verify the beneficial effect, the invention is further explained by combining clinical tests carried out by the first subsidiary hospital of the university of traditional Chinese medicine in Henan, wherein the specific experimental method and the results are as follows:
1. case selection: the selected cases are all patients with spleen deficiency diarrhea of the first subsidiary hospital of the university of traditional Chinese medicine in Henan, and 500 patients with spleen deficiency diarrhea are selected. Example 1: the number of the patients is 100, 45 men and 55 women, the course of disease is 20 days to 18 months, the number of the patients with mild diarrhea is 67, and the number of the patients with severe diarrhea is 33; example 2: the number of the patients is 100, 42 men and 58 women, the course of disease is 20 days to 18 months, the number of the patients with mild diarrhea is 66, and the number of the patients with severe diarrhea is 34; example 3: 44 men, 56 women, 20 days to 18 months in course of disease, 69 cases of mild diarrhea and 31 cases of severe diarrhea; comparative example 1: the number of the patients is 100, 44 men and 56 women, the course of disease is 20 days to 18 months, 68 cases of mild diarrhea and 32 cases of severe diarrhea; comparative example 2: total 100 cases, 43 cases for men and 57 cases for women, 20 days to 18 months for the course of disease, 65 cases for mild diarrhea and 35 cases for severe diarrhea
2. Diagnostic criteria: according to the Chinese medicine administration, the diagnosis and treatment effect standard of the traditional Chinese medicine disease, the diagnosis is confirmed according to the clinical symptoms and signs of the patient and the physicochemical examination of the western medicine diseases related to the diarrhea (such as routine excrement, excrement culture, X-ray barium enema, fiberscope enteroscopy, intestinal tract CT and the like).
3. The treatment method comprises the following steps: the navel moxibustion is carried out according to the use method of the invention, every other day is 1 time, 1 month is 1 treatment course, generally 3 treatment courses are carried out until clinical symptoms and physical signs disappear, and after physical and chemical examination of western medicine diseases related to diarrhea is normal, the treatment is carried out for 1 treatment course, and follow-up is carried out for 3 months.
4. The evaluation standard of the curative effect is as follows:
(1) The clinical cure is as follows: the times, the amount and the characters of the excrement are recovered to be normal, the symptoms and the physical signs disappear, and the physical and chemical examination of the western medicine diseases related to the diarrhea is normal.
(2) The effect is shown: the times of defecation are 2-3 times per day, the approximate forming is realized, or the loose stool is only 1 time per day, the total integral of accompanying symptoms and physical signs is reduced by more than or equal to 70 percent compared with the total integral before treatment, and the physical and chemical examination and the reexamination of the western medicine diseases related to the diarrhea are obviously improved;
(3) The frequency and the quality of the excrement are improved, the total integral of accompanying symptoms and physical signs is reduced by more than or equal to 35 percent and less than 70 percent compared with the total integral before treatment, and the physical and chemical examination and reexamination of the western medicine diseases related to the diarrhea are improved;
(4) Invalid, one not meeting the valid standard
5. The observation indexes of the curative effect are as follows: total integral of symptom signs: according to the main symptom sign scoring table, the common symptoms of the patients, such as enlarged tongue, tooth marks on the side, abdominal pain, diarrhea, appetite, sleeping conditions and the like, are observed and inquired, and are recorded in detail, the total score is the sum of the symptoms and sign scores of the patients, and the higher the score is, the more serious the symptoms and signs are.
6. The treatment effect is as follows: the invention is applied to 100 clinical cases of patients with spleen deficiency diarrhea for 3 courses of treatment, and the treatment effect evaluation is carried out by applying the treatment effect evaluation standard: 70 cases are cured, and the cure rate is about 70%; 26 cases of improvement, accounting for about 26 percent; the number of the cases is about 4% of the cases without cure. The total effective rate is about 96%. The therapeutic effects are shown in tables 2 and 3.
6.1 comparison of clinical efficacy
As shown in table 2, the clinical effective rates of inventive examples 1 to 3 were 92%, 96%, and 91%, which were higher than those of the comparative example group.
TABLE 2 comparison of the clinical efficacy of the groups after treatment
Figure RE-GDA0003996080560000101
6.2 Total integral comparison of symptom signs
As shown in Table 3, inventive examples 1-3 were able to reduce the total integral of signs of symptoms, with statistical significance, compared to pre-treatment and examples and comparative examples.
TABLE 3 Total integral comparison of symptom signs in each group before and after treatment
Figure RE-GDA0003996080560000102
Note: * P is less than 0.05 in the group compared with before treatment
Typical cases
1. Li A certain woman is 48 years old, mainly complains about the dysfunction of the spleen and the stomach, habitual diarrhea and abdominal pain, the medicine can not be radically cured after diagnosis and taking for a plurality of times in 5 years, the body is thin and weak, the face is pale yellow and anemia, the powder navel moxibustion provided by the embodiment 2 is utilized later, the excrement starts to change after 1 treatment course, the shape is a bit, after taking 2 treatment courses, the excrement is formed, after 3 treatment courses, the excrement disappears from 2-3 times a day before to 1 time a day at present, the symptoms of diarrhea and abdominal pain disappear, various foods can be used, the body weight is recovered to be normal, then the medicine is continuously treated for 3 treatment courses for consolidation, and the disease does not recur until the follow-up visit.
2. After 2 months of treatment, the diarrhea is relieved, the stool frequency is reduced, and then the treatment is continued for 4 months, the symptoms of the diarrhea and the abdominal pain disappear, and the follow-up visit is not repeated till now.
3. Yang Mou, female, age 42, zheng Zhou City of Henan province. The patient in 3 months in 2019 goes to the Beijing tumor hospital for intestinal fistula repair (not detailed), abdominal pain and diarrhea can occur when the patient goes carelessly to eat after the operation, the excrement is in a dilute water sample and is taken 5-6 times a day, the patient goes to the clinic of the traditional Chinese medicine in Zhengzhou city, and the examination of the abdomen is shown as CT: intestinal obstruction is treated in the first subsidiary hospital of Zhengzhou university, and the condition is improved after the symptomatic treatment of water and nutrient fluid infusion is forbidden. The patient is interrupted to have symptoms of abdominal pain and diarrhea, which gradually aggravate, seriously affect diet and sleep, and have symptoms of hypodynamia, perspiration and cold intolerance, so far, in order to further treat the disease with Chinese and western medicines, the disease is treated in the first subsidiary hospital of Henan university of traditional Chinese medicine, and the disease is seen: abdominal pain, loose stool, yellow color, food residue, 5-6 times daily, asthenia, aversion to cold, sweating, obvious after activity, normal urination, pale tongue, thin coating, swollen and large tongue with tooth marks, and soft pulse. The traditional Chinese medicine diagnosis is as follows: diarrhea. The syndrome differentiation is as follows: the pattern of weakness of the spleen and stomach. After hospitalization, the medicinal powder provided in example 2 was subjected to umbilical moxibustion, and after 1 week, stools began to change and had a little shape; after 2 weeks of treatment according to the umbilical moxibustion method, the abdominal pain symptom is relieved, and the symptoms such as stool forming, hypodynamia, cold intolerance, sweating and the like are better improved: after 1 month of treatment, the stool character, quantity and frequency are recovered to be normal, the symptoms such as abdominal pain, hypodynamia, cold intolerance, sweating and the like disappear, and then treatment is continued for 1 treatment course for consolidation, and the follow-up does not relapse until now.
4. Liu Mou, female, age 51, of the sui county, city, county, province, henan. In 2019, a patient in 6 months has diarrhea symptoms due to eating a large amount of watermelons, and the diarrhea is loose 3-4 times a day, so that the patient is not regarded as serious and treated. After the traditional Chinese medicine is eaten, the diarrhea symptom appears after people eat greasy food and cold food, the traditional Chinese medicine and the traditional Chinese medicine suppository are taken for treatment in sui county, and the treatment is improved. The later patients are not on outpatient service of the first subsidiary hospital of Henan university of traditional Chinese medicine, and the disease condition is good or bad. The patient suffers from diarrhea symptom again after catching a cold in 6-5 days in 2020, the diarrhea symptom is 3-4 times a day, the patient is accompanied with hypodynamia and sleepiness, the abdominal pain affects eating and sleeping at night, the symptom is not improved after the patient takes the norfloxacin capsule by self, and the patient is subjected to hospitalization in the first affiliated hospital of the university of traditional Chinese medicine in Henan in order to obtain further systemic treatment, and the hospitalization symptom is shown as follows: mental retardation, abdominal pain and diarrhea, fatigue, lassitude, anorexia and uneasiness to fall asleep after 3-4 times a day. The traditional Chinese medicine diagnosis is as follows: the syndrome differentiation of the diarrhea is as follows: spleen-kidney yang deficiency syndrome. After the patient is hospitalized, the medicinal powder provided in the example 2 is used for umbilical moxibustion treatment, and the patient can be cured after continuous treatment for 2 months, so that the stool has normal properties, quantity and frequency, good spirit, no fatigue, normal diet and good sleep. Then the treatment is continued for 1 course of treatment to consolidate, and the follow-up is not relapsed until now.
5. Qiao Mou, male, 35 years old, zhongmuui county, zhengzhou, henan province. The patients in 7 months in 2019 have abdominal pain and diarrhea after eating cold drinks or catching a cold, loose stool and occasional abdominal distension, and the patients get better after taking the medicine in local hospitals (details are not shown). The cold food is eaten in 2019, 9 and 21 days, and then symptoms of abdominal pain and diarrhea, watery stool, abdominal distension, nausea and vomiting appear again after the cold food is eaten for 4-5 times every day. The patient is treated in the first subsidiary hospital of the university of traditional Chinese medicine in Henan, for the purpose of systemic treatment. Admission symptoms are as follows: listlessness, abdominal pain, diarrhea, watery stool 4-5 times/day, nausea, vomiting, poor sleep and scanty urine. The traditional Chinese medicine diagnosis is as follows: the diarrhea is distinguished by the following symptoms: syndrome of deficiency-cold of spleen and stomach. After the patient is hospitalized, the umbilical moxibustion therapy is carried out by adopting the medicinal powder provided by the embodiment 2, the patient is cured after continuous treatment for 40 days, the mental performance, the stool property, the stool quantity and the stool frequency of the patient are recovered to be normal, and the patient does not have abdominal pain, nausea and vomiting and can take a sleep. Then the treatment is continued for 1 course of treatment to consolidate, and the follow-up is not relapsed until now.
7. Evaluation of safety
Through revisiting, during the period that the patients take the preparation, the patients who take the preparation of the embodiment of the application do not have side effects of abdominal skin itch, skin red and swollen, dry stool and the like, only 1 patient has slight scald condition, and other patients do not have obvious edema phenomena. When the relapse condition of the patient after stopping taking the preparation of the embodiment of the invention is tracked and investigated, the result shows that the patient does not have the repeated attack phenomenon of the spleen deficiency diarrhea within one year after taking the preparation of the embodiment of the invention, and the statistical result is shown in table 4. In conclusion, the preparation has the advantages of quick response, strong drug effect, difficult relapse and no toxic or side effect.
TABLE 4 number of adverse reactions occurring during dosing and relapse within one year after drug withdrawal
Figure RE-GDA0003996080560000121
Figure RE-GDA0003996080560000131
Note: relapse rate = (number of relapses)/(total number) х% 100%
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims (10)

1. An umbilical moxibustion medicinal powder for treating spleen deficiency diarrhea is characterized by comprising the following raw materials in parts by weight: 10-14 parts of astragalus membranaceus, 6-10 parts of codonopsis pilosula, 10-14 parts of bighead atractylodes rhizome, 4-8 parts of poria cocos, 2-6 parts of Chinese yam, 2-6 parts of honey-fried licorice root, 4-8 parts of pinellia ternate, 2-6 parts of dried orange peel, 4-8 parts of rhizoma cyperi, 1-3 parts of elecampane, 2-6 parts of coptis chinensis, 2-6 parts of fructus evodiae, 2-6 parts of round cardamon seed, 4-8 parts of angelica sinensis and 4-8 parts of white peony root.
2. The navel moxibustion powder of claim 1, wherein the raw materials comprise, in parts by weight:
10 parts of astragalus membranaceus, 6 parts of codonopsis pilosula, 10 parts of bighead atractylodes rhizome, 4 parts of poria cocos, 2 parts of Chinese yam, 2 parts of honey-fried licorice root, 4 parts of pinellia ternate, 2 parts of pericarpium citri reticulatae, 4 parts of rhizoma cyperi, 1 part of elecampane, 2 parts of coptis chinensis, 2 parts of fructus evodiae, 2 parts of fructus amomi, 4 parts of angelica sinensis and 4 parts of radix paeoniae alba.
3. The navel moxibustion powder of claim 1, wherein the raw materials comprise, in parts by weight:
12 parts of astragalus membranaceus, 8 parts of codonopsis pilosula, 12 parts of bighead atractylodes rhizome, 6 parts of poria cocos, 4 parts of Chinese yam, 4 parts of honey-fried licorice root, 6 parts of pinellia ternate, 4 parts of pericarpium citri reticulatae, 6 parts of rhizoma cyperi, 2 parts of elecampane, 4 parts of coptis chinensis, 4 parts of fructus evodiae, 4 parts of fructus amomi, 6 parts of angelica sinensis and 6 parts of radix paeoniae alba.
4. The navel moxibustion powder of claim 1, wherein the raw materials comprise, in parts by weight:
14 parts of astragalus membranaceus, 10 parts of codonopsis pilosula, 14 parts of bighead atractylodes rhizome, 8 parts of poria cocos, 6 parts of Chinese yam, 6 parts of honey-fried licorice root, 8 parts of pinellia ternate, 6 parts of pericarpium citri reticulatae, 8 parts of rhizoma cyperi, 3 parts of elecampane, 6 parts of coptis chinensis, 6 parts of fructus evodiae, 6 parts of fructus amomi, 8 parts of angelica sinensis and 8 parts of radix paeoniae alba.
5. Use of the navel moxibustion powder of any one of claims 1 to 4 in the preparation of a medicament for treating diarrhea due to spleen deficiency.
6. The use of claim 5, wherein the medicament is in a dosage form selected from the group consisting of umbilicus moxibustion powders.
7. The use of claim 6, wherein the preparation method of the navel moxibustion powder comprises the following steps:
mixing radix astragali, radix Codonopsis, atractylodis rhizoma, poria, rhizoma Dioscoreae, radix Glycyrrhizae Preparata, rhizoma Pinelliae, pericarpium Citri Tangerinae, rhizoma Cyperi, radix aucklandiae, coptidis rhizoma, fructus evodiae, fructus Amomi rotundus, radix Angelicae sinensis and radix Paeoniae alba, drying, and grinding into powder to obtain navel moxibustion powder.
8. A method of using the umbilical moxibustion powder of any one of claims 1 to 4, comprising the steps of:
sticking the punctured ginger slices on the navel part of a human body, standing, spreading the navel moxibustion medicine powder on the ginger slices, igniting the navel moxibustion medicine powder, timely taking down the ginger slices when the navel part feels burning pain, and repeating the operation for 4-5 times after the burning pain disappears.
9. The use method of claim 8, wherein the thickness of the ginger slices is 4-5mm, and the number of the pricking holes on the ginger slices is 8-10;
the punctured ginger slices are stuck to the navel part of a human body and are kept standing for 8-10 min.
10. The use method as claimed in claim 8, wherein the mass of the navel moxibustion medicine powder evenly spread on the ginger slices is 8-10 g of navel moxibustion medicine powder per 4 square centimeters of ginger slices.
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