CN115844352A - Micro-pressure real-time dynamic continuous blood pressure measuring device - Google Patents
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- 206010020772 Hypertension Diseases 0.000 description 3
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Abstract
The invention discloses a micro-pressure real-time dynamic continuous blood pressure measuring device, which comprises: the cuff module is a blood pressure cuff and is used for measuring the blood pressure of a user by an oscillometric method and real-time pulse waves under the state of 100mmHg micropressure; the acquisition module is used for acquiring PPG data and user electrocardiogram data at the front end and the rear end of the cuff module; the micro-processing module is used for processing the acquired data, controlling the cuff module to pressurize and release pressure, and sending the processed data to the receiving end; the receiving end is used for receiving the processed data and performing operation; the lithium battery module is used for providing direct current power supply for the equipment. The ECG, the PPG and the cuff pressure (micro pressure (< 100 mmHg)) of a patient are simultaneously extracted, and the waveform time sequence and the waveform characteristics of the ECG, the PPG and the cuff pressure pulse wave are analyzed in real time to estimate the real-time continuous dynamic blood pressure of the patient and realize the micro-pressure real-time continuous dynamic blood pressure measurement.
Description
Technical Field
The invention relates to the technical field of blood pressure measurement of patients with hypertension diseases, in particular to a micro-pressure real-time dynamic continuous blood pressure measuring device.
Background
At present, the real-time dynamic continuous blood pressure measurement mainly comprises the following three methods which have respective obvious defects:
1 invasive real-time dynamic continuous blood pressure measurement method:
the method needs to be carried out by a doctor to cut on the blood vessel of a patient, and the invasive blood pressure monitoring sensor is directly connected with the blood vessel of the patient through a hose, so that the real-time blood pressure data of the patient can be measured in real time.
The disadvantages of this method are: (1) The blood vessel needs to be cut open by operation, the requirement on an operator is high, the implementation difficulty is high, and meanwhile, the infection risk is high, so that the blood vessel monitoring instrument is usually only suitable for monitoring in critical or surgical operations. (2) In the use process, the limbs of the patient can not move in a large range, and meanwhile, the patient feels painful, and the experience of the patient is not good.
2 non-invasive time-sharing measurement method
The technical principle of the method is based on the traditional oscillometric blood pressure measurement method. Pseudo-continuous dynamic measurements are achieved by shortening the test interval for a patient during a hospital stay, measuring multiple times per day (greater than 10).
The disadvantages of this method are: the blood pressure monitoring device is pseudo-real-time, pseudo-continuous, large in measurement interval, incapable of capturing rapid changes of the blood pressure of a patient in a short time and possible to delay treatment time.
3, a blood pressure measuring method based on a PTT blood pressure measuring model:
the method takes the electrical cardiac signal (ECG) as the start point of PTT and the PPG signal recorded elsewhere in the body (e.g., earlobe, fingertip) as the end point of PTT. By identifying the main peaks of the ECG signal and the PGG signal, the time interval PTT of the two main peaks can be obtained. PTT and contraction pressure SBP are in linear correlation, and a linear regression equation is used for establishing a correction coefficient, so that the SBP can be accurately calculated.
The disadvantages of this method are: 1. from the principle perspective, PTT is closely related to systolic pressure in a linear mode, but is relatively poor in relation to diastolic pressure, so that the estimation of diastolic pressure by using the method alone is often not accurate enough; 2. the overall errors measured by the method are large, the method cannot meet medical clinical application, and the method can only be used on civil equipment, and the inventor provides a micro-pressure real-time dynamic continuous blood pressure measuring device for solving the problems.
Disclosure of Invention
The problem of real-time dynamic continuous blood pressure measurement of patients with hypertension is solved; the invention aims to provide a micro-pressure real-time dynamic continuous blood pressure measuring device.
In order to solve the technical problems, the invention adopts the following technical scheme: a micro-pressure real-time dynamic continuous blood pressure measuring device, comprising:
a cuff module which is a blood pressure cuff and is used for measuring the blood pressure of a user by an oscillometric method and real-time pulse waves in a micro-pressure state of <100 mmHg;
the acquisition module is used for acquiring PPG data and user electrocardio data at the front end and the rear end of the cuff module;
the micro-processing module is used for processing the acquired data, controlling the cuff module to pressurize and release pressure, and meanwhile sending the processed data to the receiving end;
the receiving end is used for receiving the processed data and performing operation;
the lithium battery module is used for providing direct current power supply for the equipment.
In a preferred embodiment, the acquisition module comprises a PPG sensor 1, a PPG sensor 2 and an ECG sensor, the PPG sensor 1, the PPG sensor 2 and the ECG sensor are all electrically connected to the micro-processing module, the PPG sensor 1 is a cuff front end sensor and acquires PPG data of the front end of a blood pressure cuff of a user, namely the proximal limb end; the PPG sensor 2 is a cuff rear end sensor and is used for acquiring PPG data of the rear end of a blood pressure cuff of a user, namely the proximal end; the ECG sensor is used for acquiring electrocardiogram data of a user.
Preferably, the micro processing module comprises an MCU, and the MCU is electrically connected with a PPG1 filtering and amplifying circuit, a PPG2 filtering and amplifying circuit, an ECG filtering and amplifying circuit, a miniature air pump, a proportional solenoid valve and a sleeve belt pressure sensor to realize AC-DC separation, filtering, amplifying circuit, a serial port chip and a lithium battery management circuit.
In an embodiment of the present invention, the MCU is configured to sort and pack data collected by the PPG sensor, the ECG sensor, and the cuff pressure sensor, and send the data to the receiving end, and control the actions of the inflation pump, the deflation valve, and the sensor.
In a preferred embodiment, the PPG1 filtering and amplifying circuit, the PPG2 filtering and amplifying circuit and the ECG filtering and amplifying circuit are respectively electrically connected to the PPG sensor 1, the PPG sensor 2 and the ECG sensor, the PPG1 filtering and amplifying circuit is used for filtering, denoising and amplifying data acquired by the PPG1 sensor, the PPG2 filtering and amplifying circuit is used for filtering, denoising and amplifying data acquired by the PPG2 sensor, and the ECG filtering and amplifying circuit is used for filtering, denoising and amplifying electrocardiographic data of a patient.
In an embodiment of the present invention, the micro air pump is used for pressurizing the cuff module according to the instruction of the MCU, the proportional solenoid valve is used for decompressing the cuff module according to the instruction of the MCU, and the cuff pressure sensor, the ac-dc separation circuit, the filtering circuit, and the amplifying circuit are used for collecting the cuff pressure waveform of the user, performing the ac-dc separation and filtering, denoising, amplifying, and then transmitting to the MCU.
In a preferred embodiment, the receiving end comprises an upper computer and a remote server, the upper computer and the measuring device are integrally installed, the serial port chip is used for transmitting data packaged and packaged by the MCU to the upper computer for operation and display, and a WIFI module or a 5G module is further arranged at the serial port chip and electrically connected with the MCU for transmitting the data packaged and packaged by the MCU to the remote server through remote communication for networking storage and operation of data of a plurality of devices; the lithium battery management circuit is used for performing charging management and overvoltage/overcurrent protection on the lithium battery.
In a preferred embodiment, the measuring process of the micro-pressure real-time dynamic continuous blood pressure measuring device comprises the following steps:
s1, starting measurement;
s2, inflating the cuff after each wearing, acquiring the blood pressure of a user once by an oscillography, and taking the blood pressure as a basic blood pressure value of the patient, and performing blood pressure calibration on the user once by the oscillography at least every 6 hours, wherein the cuff is always kept in a state of the micro pressure of less than 100mmHg after each measurement or calibration;
s3, the PPG1 sensor starts to acquire PPG data of the front end of the blood pressure cuff of the user, namely the proximal limb end in real time, and transmits the PPG data to the MCU in real time;
s4, the PPG2 sensor starts to acquire PPG data at the rear end of the blood pressure cuff of the user, namely the proximal end in real time, and transmits the PPG data to the MCU in real time;
s5, the ECG sensor starts to collect the electrocardiogram data of the user in real time and transmits the electrocardiogram data to the MCU in real time;
s6, the cuff pressure sensor starts to collect the cuff pressure of the user in real time, and the cuff pressure is subjected to alternating-current and direct-current separation, filtering, denoising and amplification and then transmitted to the MCU;
s7, the MCU starts to sort and pack data collected by the PPG sensor, the ECG sensor, the cuff pressure sensor and the like, and transmits the data to the upper computer through the serial port chip or the 5G module and the WIFI module, and simultaneously controls the inflator pump and the deflation valve;
s8, the upper computer unpacks and calculates the data transmitted by the MCU, the result is displayed, and the remote server receives the data and stores the data in a networking manner;
and S9, ending.
In a preferred embodiment, steps S3 to S6 are all real-time synchronization steps, and the time difference between them should be less than ten thousandth of a second.
Compared with the prior art, the invention has the beneficial effects that:
1. the method comprises the steps of simultaneously extracting ECG, PPG and cuff pressure (micro pressure (< 100 mmHg)) of a patient, and analyzing waveform time sequence and waveform characteristics of ECG, PPG and cuff pressure pulse waves in real time to estimate real-time continuous dynamic blood pressure of the patient, and a noninvasive measurement mode is adopted to solve the problem that the operation difficulty of cutting open blood vessels in an operation is high in invasive blood pressure monitoring; invasive monitoring of infection risk is high; the patient feels painful, and the measurement experience is poor;
2. real-time dynamic measurement (second level) is adopted, so that the problems of pseudo real-time, pseudo continuous and large measurement interval in a non-invasive time-sharing measurement method, incapability of capturing rapid change of blood pressure of a patient in a short time, possibility of delaying treatment time and the like are solved;
3. the cuff pressure and ECG and PPG are extracted simultaneously, data obtained by calculation of a PTT method are corrected in real time based on pulse waveforms of the cuff pressure, the ECG waveforms and the PPG waveforms are analyzed in real time, data of systolic pressure and particularly diastolic pressure are corrected, measurement accuracy is greatly improved, real-time dynamic continuous noninvasive blood pressure measurement which is applicable to medical use is achieved, and the problems that a blood pressure measurement method based on a PTT blood pressure measurement model is low in data measurement accuracy and cannot be applicable to medical scenes are solved.
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In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a schematic structural diagram of a module of a micro-pressure real-time dynamic continuous blood pressure measuring device provided by the invention.
Fig. 2 is a schematic connection diagram of a micro-pressure real-time dynamic continuous blood pressure measuring device unit provided by the invention.
Fig. 3 is a schematic view of a flow chart of a micro-pressure real-time dynamic continuous blood pressure measuring device provided by the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example (b): as shown in fig. 1 to 3, in order to solve the problem of real-time dynamic continuous blood pressure measurement of patients with hypertension disease, the present invention provides a micro-pressure real-time dynamic continuous blood pressure measurement device, which realizes real-time dynamic continuous blood pressure measurement conforming to clinical use by acquiring and calculating PPG, ECG and cuff pressure pulse waves of a user and correcting the cuff micro-pressure (< 100 mmHg), and the present invention provides a micro-pressure real-time dynamic continuous blood pressure measurement device, comprising:
the cuff module is a blood pressure cuff and is used for measuring the blood pressure of a user by an oscillometric method and real-time pulse waves under the state of 100mmHg micro-pressure;
the acquisition module is used for acquiring PPG data and user electrocardio data at the front end and the rear end of the cuff module;
the micro-processing module is used for processing the acquired data, controlling the cuff module to pressurize and release pressure and sending the processed data to the receiving end;
the receiving end is used for receiving the processed data and carrying out operation;
the lithium battery module is used for providing direct current power supply for the equipment.
Further, the acquisition module comprises a PPG sensor 1, a PPG sensor 2 and an ECG sensor, the PPG sensor 1, the PPG sensor 2 and the ECG sensor are all electrically connected with the micro-processing module, the PPG sensor 1 is a cuff front end sensor and is used for acquiring PPG data of the front end of a blood pressure cuff of a user, namely the proximal limb end; the PPG sensor 2 is a cuff rear end sensor and is used for acquiring PPG data of the rear end of the blood pressure cuff of the user, namely the proximal end; the ECG sensor is used to collect electrocardiographic data of the user.
Further, the microprocessing module includes MCU, and MCU electricity connects PPG1 filtering amplification circuit, PPG2 filtering amplification circuit, ECG filtering amplification circuit, miniature air pump, proportion solenoid valve, sleeve area pressure sensor with the separation of alternating current and direct, filtering, amplifier circuit, serial chips and lithium battery management circuit.
Further, the MCU is used for sorting and packaging data collected by the PPG sensor, the ECG sensor and the cuff pressure sensor, sending the data to a receiving end, and controlling the actions of devices for starting and stopping the inflator pump, the air release valve and the sensor.
Furthermore, the PPG1 filtering and amplifying circuit, the PPG2 filtering and amplifying circuit and the ECG filtering and amplifying circuit are respectively and electrically connected with the PPG sensor 1, the PPG sensor 2 and the ECG sensor, the PPG1 filtering and amplifying circuit is used for filtering, denoising and amplifying data collected by the PPG1 sensor, the PPG2 filtering and amplifying circuit is used for filtering, denoising and amplifying data collected by the PPG2 sensor, and the ECG filtering and amplifying circuit is used for filtering, denoising and amplifying electrocardiogram data of a patient.
Furthermore, the miniature air pump is used for pressurizing the cuff module according to the instruction of the MCU, the proportional solenoid valve is used for decompressing the cuff module according to the instruction of the MCU, the cuff pressure sensor and the AC-DC separation and filtering circuit are used for collecting the cuff pressure waveform of a user, and the AC-DC separation and filtering are carried out, so that the noise is removed, the amplification is carried out, and then the cuff pressure waveform is transmitted to the MCU.
Further, the receiving end comprises an upper computer and a remote server, the upper computer and the measuring device are integrally installed, the serial port chip is used for transmitting data packaged and packaged by the MCU to the upper computer for operation and display, and a WIFI module or a 5G module is further arranged at the serial port chip and electrically connected with the MCU for transmitting the data packaged and packaged by the MCU to the remote server through remote communication for data networking storage and operation of multiple devices; the lithium battery management circuit is used for performing charging management and overvoltage/overcurrent protection on the lithium battery.
Further, the measuring process of the micro-pressure real-time dynamic continuous blood pressure measuring device comprises the following steps:
s1, starting measurement;
s2, inflating the cuff after each wearing, acquiring the blood pressure of a user once by an oscillography, and taking the blood pressure as a basic blood pressure value of the patient, and performing blood pressure calibration on the user once by the oscillography at least every 6 hours, wherein the cuff is always kept in a state of the micro pressure of less than 100mmHg after each measurement or calibration;
s3, the PPG1 sensor starts to acquire PPG data of the front end of the blood pressure cuff of the user, namely the proximal limb end in real time, and transmits the PPG data to the MCU in real time;
s4, the PPG2 sensor starts to acquire PPG data at the rear end of the blood pressure cuff of the user, namely the proximal end in real time, and transmits the PPG data to the MCU in real time;
s5, the ECG sensor starts to collect the electrocardiogram data of the user in real time and transmits the electrocardiogram data to the MCU in real time;
s6, the cuff pressure sensor starts to collect the cuff pressure of the user in real time, and the cuff pressure is subjected to alternating-current and direct-current separation, filtering, denoising and amplification and then transmitted to the MCU;
s7, the MCU starts to sort and pack data collected by the PPG sensor, the ECG sensor, the cuff pressure sensor and the like, and transmits the data to the upper computer through the serial port chip or the 5G module and the WIFI module, and simultaneously controls the inflator pump and the deflation valve;
s8, the upper computer unpacks and calculates the data transmitted by the MCU, the result is displayed, and the remote server receives the data and stores the data in a networking manner;
and S9, ending.
Further, steps S3 to S6 are full real-time synchronization steps, and the time difference therebetween should be less than ten thousandth of a second.
In conclusion, the ECG, the PPG and the cuff pressure (micro pressure (< 100 mmHg)) of the patient are simultaneously extracted, and the waveform time sequence and the waveform characteristics of the ECG, the PPG and the cuff pressure pulse waves are analyzed in real time to estimate the real-time continuous dynamic blood pressure of the patient, and a noninvasive measurement mode is adopted, so that the problem that the operation of dissecting blood vessels by an operation is difficult in invasive blood pressure monitoring is solved; invasive monitoring of infection risk is high; the patient feels painful, and the measurement experience is poor; the real-time dynamic measurement (second level) is adopted, so that the problems of pseudo real-time, pseudo-continuity, large measurement interval, incapability of capturing rapid change of blood pressure of a patient in a short time, possibility of delaying treatment time and the like in a noninvasive time-sharing measurement method are solved; the cuff pressure and ECG and PPG are extracted simultaneously, data obtained by calculation of a PTT method are corrected in real time based on pulse waveforms of the cuff pressure, the ECG waveforms and the PPG waveforms are analyzed in real time, data of systolic pressure and particularly diastolic pressure are corrected, measurement accuracy is greatly improved, real-time dynamic continuous noninvasive blood pressure measurement which is applicable to medical use is achieved, and the problems that a blood pressure measurement method based on a PTT blood pressure measurement model is low in data measurement accuracy and cannot be applicable to medical scenes are solved.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (9)
1. A micro-pressure real-time dynamic continuous blood pressure measuring device is characterized by comprising:
a cuff module which is a blood pressure cuff and is used for measuring the blood pressure of a user by an oscillometric method and real-time pulse waves in a micro-pressure state of <100 mmHg;
the acquisition module is used for acquiring PPG data and user electrocardio data at the front end and the rear end of the cuff module;
the micro-processing module is used for processing the acquired data, controlling the cuff module to pressurize and release pressure, and meanwhile sending the processed data to the receiving end;
the receiving end is used for receiving the processed data and carrying out operation;
the lithium battery module is used for providing direct current power supply for the equipment.
2. The micro-pressure real-time dynamic continuous blood pressure measuring device as claimed in claim 1, wherein the acquisition module comprises a PPG sensor 1, a PPG sensor 2 and an ECG sensor, the PPG sensor 1, the PPG sensor 2 and the ECG sensor are all electrically connected with the micro-processing module, the PPG sensor 1 is a cuff front end sensor, and acquires PPG data of the front end of a blood pressure cuff of the user, namely the proximal limb end; the PPG sensor 2 is a cuff rear end sensor and is used for acquiring PPG data of the rear end of a blood pressure cuff of a user, namely the proximal end; the ECG sensor is used for acquiring electrocardiogram data of a user.
3. The micro-pressure real-time dynamic continuous blood pressure measuring device as claimed in claim 2, wherein the micro-processing module comprises an MCU, the MCU is electrically connected with a PPG1 filter amplifying circuit, a PPG2 filter amplifying circuit, an ECG filter amplifying circuit, a micro air pump, a proportional solenoid valve, a cuff pressure sensor to separate AC and DC, a filter, an amplifying circuit, a serial port chip and a lithium battery management circuit.
4. The micro-pressure real-time dynamic continuous blood pressure measuring device according to claim 3, wherein the MCU is used for sorting and packing the data collected by the PPG sensor, the ECG sensor and the cuff pressure sensor, sending the data to the receiving end, and controlling the actions of the devices for starting and stopping the inflator pump, the deflation valve and the sensor.
5. The micro-pressure real-time dynamic continuous blood pressure measuring device as claimed in claim 3, wherein the PPG1 filter amplifier circuit, the PPG2 filter amplifier circuit and the ECG filter amplifier circuit are respectively electrically connected to the PPG sensor 1, the PPG sensor 2 and the ECG sensor, the PPG1 filter amplifier circuit is used for filtering, de-noising and amplifying data collected by the PPG1 sensor, the PPG2 filter amplifier circuit is used for filtering, de-noising and amplifying data collected by the PPG2 sensor, and the ECG filter amplifier circuit is used for filtering, de-noising and amplifying electrocardiographic data of a patient.
6. The micro-pressure real-time dynamic continuous blood pressure measuring device as claimed in claim 3, wherein the micro air pump is used for pressurizing the cuff module according to the instruction of the MCU, the proportional solenoid valve is used for decompressing the cuff module according to the instruction of the MCU, the cuff pressure sensor and the AC-DC separation, filtering, amplifying circuit is used for collecting the cuff pressure waveform of the user, and performing the AC-DC separation and filtering, denoising, amplifying, and then transmitting to the MCU.
7. The micro-pressure real-time dynamic continuous blood pressure measuring device as claimed in claim 3, wherein the receiving end comprises an upper computer and a remote server, the upper computer and the measuring device are integrally installed, the serial port chip is used for transmitting the data packaged and packaged by the MCU to the upper computer for operation and display at the same time, and a WIFI module or a 5G module is further arranged at the serial port chip and electrically connected with the MCU for transmitting the data packaged and packaged by the MCU to the remote server through remote communication for networking, storing and operating data of a plurality of devices; the lithium battery management circuit is used for performing charging management and overvoltage/overcurrent protection on the lithium battery.
8. The micro-pressure rtd apparatus according to claim 7, wherein the measurement process of the micro-pressure rtd apparatus comprises the following steps:
s1, starting measurement;
s2, inflating the cuff after each wearing, acquiring the blood pressure of a user once by an oscillography, and taking the blood pressure as a basic blood pressure value of the patient, and performing blood pressure calibration on the user once by the oscillography at least every 6 hours, wherein the cuff is always kept in a state of the micro pressure of less than 100mmHg after each measurement or calibration;
s3, the PPG1 sensor starts to acquire PPG data of the front end of the blood pressure cuff of the user, namely the proximal limb end in real time, and transmits the PPG data to the MCU in real time;
s4, the PPG2 sensor starts to acquire PPG data at the rear end of the blood pressure cuff of the user, namely the proximal end in real time, and transmits the PPG data to the MCU in real time;
s5, the ECG sensor starts to acquire the electrocardiogram data of the user in real time and transmits the electrocardiogram data to the MCU in real time;
s6, the cuff pressure sensor starts to acquire the cuff pressure of a user in real time, and the cuff pressure is subjected to alternating-current and direct-current separation, filtering, denoising and amplification and then transmitted to the MCU;
s7, the MCU starts to sort and pack data collected by the PPG sensor, the ECG sensor, the cuff pressure sensor and the like, and transmits the data to the upper computer through the serial port chip or the 5G module and the WIFI module, and simultaneously controls the inflator pump and the deflation valve;
s8, the upper computer unpacks and calculates the data transmitted by the MCU, the result is displayed, and the remote server receives the data and stores the data in a networking manner;
and S9, ending.
9. The device as claimed in claim 8, wherein the steps S3 to S6 are completely real-time synchronous steps, and the time difference between the steps S3 and S6 is less than ten thousandth of a second.
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| CN104042200A (en) * | 2014-06-24 | 2014-09-17 | 北京航空航天大学 | Non-invasive monitoring device and method for beat-to-beat arterial blood pressure |
| CN109512410A (en) * | 2018-12-26 | 2019-03-26 | 东南大学 | A kind of more physiological signal Fusion Features without cuff continuous BP measurement method |
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- 2022-11-08 CN CN202211391615.2A patent/CN115844352A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060074322A1 (en) * | 2004-09-30 | 2006-04-06 | Jerusalem College Of Technology | Measuring systolic blood pressure by photoplethysmography |
| CN102178518A (en) * | 2011-05-31 | 2011-09-14 | 北京新兴阳升科技有限公司 | Individualized correction method and device used for continuous measurement and estimation of arterial blood pressure by pulse wave |
| CN202335858U (en) * | 2011-11-03 | 2012-07-18 | 吴锋 | Beat-to-beat blood pressure detection device |
| CN104042200A (en) * | 2014-06-24 | 2014-09-17 | 北京航空航天大学 | Non-invasive monitoring device and method for beat-to-beat arterial blood pressure |
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