CN115605485A - 大环化合物的固体形式及其制备和用途 - Google Patents
大环化合物的固体形式及其制备和用途 Download PDFInfo
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Abstract
本发明涉及式(A)化合物(化合物A)的游离碱或其药学上可接受盐的结晶形式，其制备方法，以及所述化合物在制备用于治疗和/或预防与ALK激酶及其突变体介导的疾病，例如细胞增殖性疾病、炎症、感染、免疫性疾病、器官移植、病毒性疾病、心血管疾病或代谢性疾病中的用途。
Description
PCT国内申请，说明书已公开。
Claims (126)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010421308 | 2020-05-18 | ||
| CN2020104213089 | 2020-05-18 | ||
| PCT/CN2021/094362 WO2021233296A1 (zh) | 2020-05-18 | 2021-05-18 | 大环化合物的固体形式及其制备和用途 |
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| MX2024003738A (es) | 2021-10-01 | 2024-06-19 | Nuvalent Inc | Formas solidas, composiciones farmaceuticas y preparacion de compuestos de eter macrociclico heteroaromatico. |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104169286A (zh) * | 2012-03-06 | 2014-11-26 | 辉瑞大药厂 | 用于治疗增殖性疾病的大环衍生物 |
| CN109152738A (zh) * | 2016-03-31 | 2019-01-04 | 韦斯夸尔德有限公司 | 组合物 |
| CN110407856A (zh) * | 2016-03-03 | 2019-11-05 | 深圳市塔吉瑞生物医药有限公司 | 一种大环化合物及包含该化合物的组合物 |
| CN111233833A (zh) * | 2018-11-28 | 2020-06-05 | 深圳市塔吉瑞生物医药有限公司 | 一种氘代大环化合物的制备方法 |
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- 2021-05-18 US US17/925,173 patent/US20230174554A1/en active Pending
- 2021-05-18 CN CN202180034182.2A patent/CN115605485A/zh active Pending
- 2021-05-18 EP EP21809732.7A patent/EP4137495A4/en active Pending
- 2021-05-18 JP JP2022570340A patent/JP2023529068A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104169286A (zh) * | 2012-03-06 | 2014-11-26 | 辉瑞大药厂 | 用于治疗增殖性疾病的大环衍生物 |
| CN110407856A (zh) * | 2016-03-03 | 2019-11-05 | 深圳市塔吉瑞生物医药有限公司 | 一种大环化合物及包含该化合物的组合物 |
| CN109152738A (zh) * | 2016-03-31 | 2019-01-04 | 韦斯夸尔德有限公司 | 组合物 |
| CN111233833A (zh) * | 2018-11-28 | 2020-06-05 | 深圳市塔吉瑞生物医药有限公司 | 一种氘代大环化合物的制备方法 |
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| WO2021233296A1 (zh) | 2021-11-25 |
| EP4137495A4 (en) | 2023-09-20 |
| JP2023529068A (ja) | 2023-07-07 |
| EP4137495A1 (en) | 2023-02-22 |
| US20230174554A1 (en) | 2023-06-08 |
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