CN115279405A - 一种抗pd-1抗体在制备治疗肢端黑色素瘤的药物中的用途 - Google Patents
一种抗pd-1抗体在制备治疗肢端黑色素瘤的药物中的用途 Download PDFInfo
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- CN115279405A CN115279405A CN202180019855.7A CN202180019855A CN115279405A CN 115279405 A CN115279405 A CN 115279405A CN 202180019855 A CN202180019855 A CN 202180019855A CN 115279405 A CN115279405 A CN 115279405A
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Abstract
提供一种抗PD‑1抗体与阿帕替尼在制备治疗肢端黑色素瘤的药物中的用途，该方案对肢端黑色素瘤疾病控制率达72.2％，对疾病客观缓解率为22.2％。还提供了一种抗PD‑1抗体、阿帕替尼和替莫唑胺在制备治疗黑色素瘤的药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (20)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020102781504 | 2020-04-10 | ||
| CN202010278150 | 2020-04-10 | ||
| PCT/CN2021/000069 WO2021203769A1 (zh) | 2020-04-10 | 2021-04-09 | 一种抗pd-1抗体在制备治疗肢端黑色素瘤的药物中的用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115279405A true CN115279405A (zh) | 2022-11-01 |
Family
ID=78023849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180019855.7A Pending CN115279405A (zh) | 2020-04-10 | 2021-04-09 | 一种抗pd-1抗体在制备治疗肢端黑色素瘤的药物中的用途 |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN115279405A (zh) |
| TW (1) | TW202144007A (zh) |
| WO (1) | WO2021203769A1 (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108601831A (zh) * | 2016-10-10 | 2018-09-28 | 苏州盛迪亚生物医药有限公司 | 一种抗pd-1抗体和vegfr抑制剂联合在制备治疗癌症的药物中的用途 |
| CN109893654A (zh) * | 2017-12-11 | 2019-06-18 | 江苏恒瑞医药股份有限公司 | Vegfr抑制剂治疗肿瘤的方法 |
| CN110882385A (zh) * | 2018-09-07 | 2020-03-17 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗肿瘤中的用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101676267B (zh) * | 2008-09-16 | 2012-12-26 | 江苏恒瑞医药股份有限公司 | N-[4-(1-氰基环戊基)苯基]-2-(4-吡啶甲基)氨基-3-吡啶甲酰胺的盐 |
| UA119659C2 (uk) * | 2013-12-12 | 2019-07-25 | Шанхай Хенжуй Фармасьютикал Ко., Лтд. | Антитіло до pd-1, його антигензв'язуючий фрагмент та їхнє медичне застосування |
| UA124259C2 (uk) * | 2015-09-28 | 2021-08-18 | Сужоу Санкадіа Байофармасьютікалз Ко., Лтд. | Фармацевтичне одержання стабільного анти-pd-1 антитіла та його застосування в медицині |
| CN108079292A (zh) * | 2016-11-23 | 2018-05-29 | 苏州盛迪亚生物医药有限公司 | 一种抗pd-1抗体在制备治疗肝癌的药物中的用途 |
| CN106963948A (zh) * | 2017-05-12 | 2017-07-21 | 顾艳宏 | 阿帕替尼与Anti‑PD‑1抗体联用在制备结肠癌药物中的应用 |
-
2021
- 2021-04-09 WO PCT/CN2021/000069 patent/WO2021203769A1/zh active Application Filing
- 2021-04-09 TW TW110112949A patent/TW202144007A/zh unknown
- 2021-04-09 CN CN202180019855.7A patent/CN115279405A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108601831A (zh) * | 2016-10-10 | 2018-09-28 | 苏州盛迪亚生物医药有限公司 | 一种抗pd-1抗体和vegfr抑制剂联合在制备治疗癌症的药物中的用途 |
| CN109893654A (zh) * | 2017-12-11 | 2019-06-18 | 江苏恒瑞医药股份有限公司 | Vegfr抑制剂治疗肿瘤的方法 |
| CN110882385A (zh) * | 2018-09-07 | 2020-03-17 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗肿瘤中的用途 |
Non-Patent Citations (4)
| Title |
|---|
| ALEXANDER N. SHOUSHTARI等: "Efficacy of Anti-PD-1 Agents in Acral and Mucosal Melanoma", 《CANCER》, vol. 122, no. 21, 17 August 2016 (2016-08-17), pages 3354, XP071097357, DOI: 10.1002/cncr.30259 * |
| DI WU: "Neoadjuvant SHR-1210 Plus Apatinib for Resectable Stage III-IV Acral Melanoma", 《CLINICAL TRAILS》, 31 March 2020 (2020-03-31), pages 1 - 10 * |
| XUAN WANG等: "Apatinib combined with camrelizumab in advanced acral melanoma patients: An open-label, single-arm phase 2 trial", 《EUR J CANCER》, vol. 182, 12 January 2023 (2023-01-12), pages 57 - 65, XP087275196, DOI: 10.1016/j.ejca.2022.12.027 * |
| 崔传亮等: "阿帕替尼联合替莫唑胺治疗常规治疗失败的晚期黑色素瘤的疗效分析", 《临床肿瘤学杂志》, vol. 22, no. 6, 15 June 2017 (2017-06-15), pages 548 - 552 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021203769A1 (zh) | 2021-10-14 |
| TW202144007A (zh) | 2021-12-01 |
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