CN115262223A - Polyester/chitosan gel composite fiber membrane and preparation method thereof - Google Patents
Polyester/chitosan gel composite fiber membrane and preparation method thereof Download PDFInfo
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- CN115262223A CN115262223A CN202211011134.4A CN202211011134A CN115262223A CN 115262223 A CN115262223 A CN 115262223A CN 202211011134 A CN202211011134 A CN 202211011134A CN 115262223 A CN115262223 A CN 115262223A
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- polyester
- chitosan
- fiber membrane
- composite fiber
- gel composite
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- 229920001661 Chitosan Polymers 0.000 title claims abstract description 78
- 239000000835 fiber Substances 0.000 title claims abstract description 67
- 229920000728 polyester Polymers 0.000 title claims abstract description 62
- 239000012528 membrane Substances 0.000 title claims abstract description 45
- 239000002131 composite material Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 27
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000001263 FEMA 3042 Substances 0.000 claims abstract description 20
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 claims abstract description 20
- 229920002258 tannic acid Polymers 0.000 claims abstract description 20
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 claims abstract description 20
- 229940033123 tannic acid Drugs 0.000 claims abstract description 20
- 235000015523 tannic acid Nutrition 0.000 claims abstract description 20
- RHQDFWAXVIIEBN-UHFFFAOYSA-N Trifluoroethanol Chemical compound OCC(F)(F)F RHQDFWAXVIIEBN-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000001523 electrospinning Methods 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000012046 mixed solvent Substances 0.000 claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 238000009987 spinning Methods 0.000 claims description 7
- 229920001610 polycaprolactone Polymers 0.000 claims description 6
- 239000004632 polycaprolactone Substances 0.000 claims description 6
- 230000006196 deacetylation Effects 0.000 claims description 3
- 238000003381 deacetylation reaction Methods 0.000 claims description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 2
- 229920000954 Polyglycolide Polymers 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 230000001678 irradiating effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 7
- 239000000499 gel Substances 0.000 description 24
- 229920001864 tannin Polymers 0.000 description 8
- 235000018553 tannin Nutrition 0.000 description 8
- 239000001648 tannin Substances 0.000 description 8
- 230000008901 benefit Effects 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 229920001410 Microfiber Polymers 0.000 description 2
- 239000003431 cross linking reagent Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- AZKVWQKMDGGDSV-BCMRRPTOSA-N Genipin Chemical compound COC(=O)C1=CO[C@@H](O)[C@@H]2C(CO)=CC[C@H]12 AZKVWQKMDGGDSV-BCMRRPTOSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010041 electrostatic spinning Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- AZKVWQKMDGGDSV-UHFFFAOYSA-N genipin Natural products COC(=O)C1=COC(O)C2C(CO)=CCC12 AZKVWQKMDGGDSV-UHFFFAOYSA-N 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- -1 methacryloyl Chemical group 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002062 molecular scaffold Substances 0.000 description 1
- 239000002121 nanofiber Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- D—TEXTILES; PAPER
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- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/224—Esters of carboxylic acids; Esters of carbonic acid
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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-
- A—HUMAN NECESSITIES
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
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- D01D5/34—Core-skin structure; Spinnerette packs therefor
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- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4382—Stretched reticular film fibres; Composite fibres; Mixed fibres; Ultrafine fibres; Fibres for artificial leather
- D04H1/43825—Composite fibres
- D04H1/43828—Composite fibres sheath-core
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- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
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- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
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- D06M10/00—Physical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents, or magnetic fields; Physical treatment combined with treatment with chemical compounds or elements
- D06M10/001—Treatment with visible light, infrared or ultraviolet, X-rays
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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- D06M2101/16—Synthetic fibres, other than mineral fibres
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Abstract
The invention belongs to the technical field of composite fiber membranes, and particularly relates to a polyester/chitosan gel composite fiber membrane and a preparation method thereof, wherein the thickness of the polyester/chitosan gel composite fiber membrane is 100-800 mu m, and the polyester/chitosan gel composite fiber membrane is composed of superfine fibers with the diameter of 300-800nm, and the preparation method of the polyester/chitosan gel composite fiber membrane is characterized in that a coaxial electrospinning and photocrosslinking method is adopted, and a core solution formed by dissolving polyester in trifluoroethanol and an outer layer solution formed by dissolving chitosan in a mixed solvent composed of trifluoroethanol and acetic acid with the mass percentage concentration of 2% according to the volume ratio of 1; the preparation method is simple and easy in process, the tensile strength of the prepared polyester/chitosan gel composite fiber membrane loaded with the tannic acid is greater than or equal to 5.4Mpa, the antibacterial rate is greater than or equal to 72%, and the polyester/chitosan gel composite fiber membrane has good biocompatibility, degradability, antibacterial property and mechanical property and can be applied to the technical field of wound dressing.
Description
The technical field is as follows:
the invention belongs to the technical field of composite fiber membranes, and particularly relates to a polyester/chitosan gel composite fiber membrane and a preparation method thereof, which can entrap and release drugs.
The background art comprises the following steps:
the chitosan nano fiber scaffold prepared by the electrostatic spinning technology has the advantages of high specific surface area and simulation of extracellular matrix, and is widely concerned in the field of medical tissue engineering. The chitosan fiber is prepared by deacetylation through concentrated alkali treatment, and has the effects of degradability, good biocompatibility, antibiosis, hemostasis and the like. In order to improve the wet stability and mechanical property of chitosan fiber, covalent cross-linking agents (glutaraldehyde, genipin, acrylamide and the like) are required to participate in a cross-linking reaction when chitosan gel is constructed, but the chemical agents are not environment-friendly and have higher price. Wherein the introduction of the aldehyde cross-linking agent also increases the cytotoxicity of the nanofiber membrane and reduces the biocompatibility of the material (LanGQ, luBT, wangtY, wangLJ, chenJH, yuK, liuJW, daiFYandWuDY. Chitosan/gelatin compatibility and available surfactant. Colloid and surface B-Biointerfaces,2015, 136.
Tannic acid generally refers to tannic acid, is a tannin obtained from gallnut, has wide sources, can sterilize bacteria, and has the advantages of environmental protection, low cost and the like. Meanwhile, the tannin can form hydrogen bonds with hydroxyl and amino of the chitosan to play a role in crosslinking. However, the mechanical properties of chitosan fibers loaded with tannic acid in the prior art are low (KiechelMA, schauercl. Non-covalent cross fibers. Carbohydratepolymers.2013, 95. Therefore, the polyester/chitosan gel composite fiber membrane and the preparation method thereof are researched and designed, and the polyester/chitosan gel composite fiber membrane has economic and social benefits.
The invention content is as follows:
the invention aims to overcome the defects in the prior art, and develops and designs a polyester/chitosan gel composite fiber membrane loaded with tannic acid and having higher mechanical property, antibacterial property and biocompatibility and simple preparation method process and a preparation method thereof.
In order to achieve the above object, the present invention relates to a polyester/chitosan gel composite fiber film having a thickness of 100 to 800 μm and composed of ultrafine fibers having a diameter of 300 to 800nm, wherein the ultrafine fibers are composed of chitosan and polyester in a ratio of 1: (2-5) the content of tannic acid per mg of the microfine fiber is 50-400. Mu.g.
The chitosan related to the invention comprises methacryloylated chitosan, the weight average molecular weight of the chitosan is 150-400kDa, the deacetylation degree is more than 80 percent, and the grafting ratio of the methacryloyl molecules is 20-80 percent; the polyester is degradable polyester, including polycaprolactone, polylactide, polyglycolide and copolymers thereof.
The preparation method of the polyester/chitosan gel composite fiber membrane comprises the following process steps:
1) Dissolving polyester in trifluoroethanol to prepare an inner core solution with the concentration of 100-200 mg/mL;
2) Dissolving chitosan in a mixed solvent to prepare an outer layer solution with the concentration of 20-50 mg/mL;
the mixed solvent is a mixture consisting of trifluoroethanol and 2% acetic acid in a volume ratio of 1;
3) Carrying out electric spinning on the outer layer solution and the inner core solution to obtain a polyester/chitosan fiber membrane with the thickness of 100-800 mu m;
the electrospinning conditions are as follows: the flow rate of the inner core solution is 0.3-0.8mL/h, the flow rate of the outer layer solution is 0.4-1.0mL/h, the spinning voltage is 10-20kV, and the receiving distance is 10-25cm;
4) Immersing the polyester/chitosan fiber film in an ethanol solution containing 1-5% of tannic acid and 1% of 2959 photoinitiator for 1-10min, and irradiating under ultraviolet light (100-200 w) for 1-2min to obtain the tannic acid-loaded polyester/chitosan gel composite fiber film.
Compared with the prior art, the tannin-loaded polyester/chitosan gel composite fiber membrane is obtained by using a coaxial electrospinning and photocrosslinking method and dissolving polyester in trifluoroethanol to form an inner core solution and dissolving chitosan in a mixed solvent of trifluoroethanol and 2% acetic acid in a volume ratio of 1; the preparation method is simple and easy in process, the tensile strength of the prepared polyester/chitosan gel composite fiber membrane loaded with the tannin is more than or equal to 5.4Mpa, the antibacterial rate is more than or equal to 72%, and the polyester/chitosan gel composite fiber membrane has good biocompatibility, degradability, antibacterial property and mechanical property and can be applied to the technical field of wound dressing.
The specific implementation method comprises the following steps:
the present invention will be further described below by way of specific embodiments.
Example 1:
the preparation method of the polyester/chitosan gel composite fiber membrane related to the embodiment comprises the following steps:
dissolving 200mg of polycaprolactone in 1mL of trifluoroethanol to be used as an inner core solution;
dissolving 50mg of methacrylated chitosan in 1mL of a mixed solvent composed of trifluoroethanol and 2% by mass of acetic acid according to a volume ratio of 1;
carrying out electrospinning by a coaxial electrospinning device under the conditions that the flow rate of the inner core solution is 0.4mL/h, the flow rate of the outer shell solution is 0.6mL/h, the spinning voltage is 12kV and the receiving distance is 15cm, collecting superfine fibers with the diameters of 200-800nm, and accumulating to obtain the polyester/chitosan fiber membrane;
the polyester/chitosan fiber membrane was immersed in an ethanol solution containing 1% by weight of 2959 photoinitiator and 3% of tannic acid for 10min, and then irradiated with ultraviolet light (200 w) for 1min to obtain a tannic acid-supported polyester/chitosan gel composite fiber membrane.
As a comparative group:
dissolving 120mg of polycaprolactone in 1mL of trifluoroethanol to be used as an inner core solution;
dissolving 20mg of chitosan (200 kDa) in a mixed solvent of 1mL of trifluoroethanol and 2% by mass of acetic acid according to a volume ratio of 1;
carrying out electrospinning by a coaxial electrospinning device under the conditions that the flow rate of the inner core solution is 0.4mL/h, the flow rate of the outer shell solution is 0.6mL/h, the spinning voltage is 12kV and the receiving distance is 15cm, collecting superfine fibers with the diameters of 200-800nm, and accumulating to obtain the polyester/chitosan composite fiber membrane;
tests prove that the tensile strength of the polyester/chitosan gel composite fiber membrane loaded with the tannin is 6.5Mpa, and the bacteriostasis rate is 80%;
the tensile strength of the polyester/chitosan composite fiber membrane is 4.0Mpa, and the bacteriostatic rate is only 40%;
the mechanical property and the antibacterial property of the polyester/chitosan gel composite fiber membrane loaded with the tannic acid are superior to those of a comparison group;
this advantage is caused by, on the one hand, the modification and photo-crosslinking process of chitosan, which makes the crosslinked network structure of chitosan formed in the fiber, increase the tensile strength of the tannin-loaded polyester/chitosan gel composite fiber membrane, and on the other hand, tannin is combined with chitosan by the action of hydrogen bonds and the like, giving the tannin-loaded polyester/chitosan gel composite fiber membrane more excellent antibacterial properties.
Example 2:
the preparation method of the polyester/chitosan gel composite fiber membrane related to the embodiment comprises the following steps:
dissolving 120mg of polycaprolactone in 1mL of trifluoroethanol to be used as an inner core solution;
dissolving 20mg of methacrylated chitosan (200 kDa) in 1mL of a mixed solvent composed of trifluoroethanol and 2% by mass of acetic acid according to a volume ratio of 1;
carrying out electrospinning by a coaxial electrospinning device under the conditions that the flow rate of the inner core solution is 0.4mL/h, the flow rate of the outer shell solution is 0.6mL/h, the spinning voltage is 12kV and the receiving distance is 15cm, collecting superfine fibers with the diameters of 200-800nm, and accumulating to obtain the polyester/chitosan fiber membrane;
the polyester/chitosan fiber film was immersed in an ethanol solution containing 1% of 2959 photoinitiator and 5% of tannic acid for 5min, and then irradiated under ultraviolet light (200 w) for 1min to obtain a tannic acid-loaded polyester/chitosan gel composite fiber film, and it was confirmed through experiments that the tensile strength of the tannic acid-loaded polyester/chitosan gel composite fiber film was 6.5Mpa and the bacteriostatic ratio was 80%.
Example 3:
the preparation method of the polyester/chitosan gel composite fiber membrane related to the embodiment comprises the following steps:
dissolving 120mg of polycaprolactone in 1mL of trifluoroethanol to be used as an inner core solution;
dissolving 20mg of methacrylated chitosan (200 kDa) in 1mL of a mixed solvent consisting of trifluoroethanol and 2% by mass of acetic acid according to a volume ratio of 1;
carrying out electrospinning by a coaxial electrospinning device under the conditions that the flow rate of the inner core solution is 0.4mL/h, the flow rate of the outer shell solution is 0.6mL/h, the spinning voltage is 12kV and the receiving distance is 15cm, collecting superfine fibers with the diameters of 200-800nm, and accumulating to obtain the polyester/chitosan fiber membrane;
the polyester/chitosan fiber film was immersed in an ethanol solution containing 1% of 2959 photoinitiator and 1% of tannic acid for 1min, and then irradiated under ultraviolet light (100 w) for 2min to obtain a tannic acid-loaded polyester/chitosan gel composite fiber film, and it was confirmed through experiments that the tensile strength of the tannic acid-loaded polyester/chitosan gel composite fiber film was 5.4Mpa and the bacteriostatic ratio was 72%.
Claims (8)
1. A polyester/chitosan gel composite fiber membrane with the thickness of 100-800 μm and the diameter of 300-800nm is characterized in that the superfine fiber is formed by chitosan and polyester according to the ratio of 1: (2-5) the content of tannic acid per mg of the microfine fiber is 50-400. Mu.g.
2. The polyester/chitosan gel composite fiber membrane according to claim 1, wherein the chitosan comprises methacrylated chitosan, the weight average molecular weight of the chitosan is 150-400kDa, the degree of deacetylation is greater than 80%, and the grafting ratio of methacrylated molecules is 20-80%.
3. The polyester/chitosan gel composite fiber membrane according to claim 1 or 2, wherein the polyester is a degradable polyester, including polycaprolactone, polylactide, polyglycolide, and copolymers thereof.
4. A preparation method of a polyester/chitosan gel composite fiber membrane is characterized by comprising the following process steps:
1) Dissolving polyester in trifluoroethanol to prepare an inner core solution;
2) Dissolving chitosan in a mixed solvent to prepare an outer layer solution;
the mixed solvent is a mixture of trifluoroethanol and acetic acid;
3) Carrying out electrospinning on the outer layer solution and the inner core solution to obtain a polyester/chitosan fiber membrane;
4) And (2) immersing the polyester/chitosan fiber membrane into an ethanol solution containing tannic acid and 2959 photoinitiator for 1-10min, and radiating under ultraviolet light to obtain the tannic acid-loaded polyester/chitosan gel composite fiber membrane.
5. The method for preparing a polyester/chitosan gel composite fiber membrane according to claim 4, wherein the concentration of the inner core solution involved in the step 1) is 100-200mg/mL.
6. The preparation method of the polyester/chitosan gel composite fiber membrane according to claim 4, wherein the volume ratio of the trifluoroethanol to the acetic acid in the mixed solvent involved in the step 2) is 1; the concentration of the outer layer solution is 20-50mg/mL.
7. The method for preparing the polyester/chitosan gel composite fiber membrane according to claim 4, wherein the electrospinning conditions involved in the step 3) are as follows: the flow rate of the inner core solution is 0.3-0.8mL/h, the flow rate of the outer layer solution is 0.4-1.0mL/h, the spinning voltage is 10-20kV, and the receiving distance is 10-25cm; the thickness of the polyester/chitosan fiber film is 100-800 μm.
8. The method for preparing a polyester/chitosan gel composite fiber membrane as claimed in claim 4, wherein the ethanol solution involved in the step 4) contains 1-5% of tannic acid and 1% of 2959 photoinitiator; irradiating under 100-200w ultraviolet light for 1-2min.
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| CN115262223B (en) | 2023-12-26 |
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