CN115252007A - Biopsy sampling device - Google Patents

Abstract

The invention discloses a biopsy sampling device, wherein a negative pressure tube and a cutting blade are movably arranged on a sampling main body, when the focal tissue needs to be operated, partial focal tissue is sucked through a suction port of the negative pressure tube, the cutting blade moves on the sampling main body to close a sampling opening, the tissue is separated, the cutting blade can be operated repeatedly, the collected fragmentary samples can be continuously obtained through the negative pressure tube, larger tissue samples can be drawn out of the sampling main body along with the negative pressure tube, the sampling time is shortened, and the application range of the device is expanded.

Description

Biopsy sampling device

Technical Field

The invention relates to the technical field of biopsy sampling, in particular to a biopsy sampling device.

Background

Tumors are diseases seriously harming human health and life, and because some tumors do not have typical imaging characteristics, diagnosis is difficult, and correct diagnosis needs to be carried out by combining clinic diagnosis, pathology diagnosis and the like, wherein needle biopsy is a main way for obtaining pathological diagnosis. Endoscopy is currently widely used in the clinic as an auxiliary diagnostic method. The biopsy sampling device is a special surgical instrument for needle biopsy, enters a patient body through a channel of an endoscope to clamp tissues of a lesion part, and performs pathological analysis on the clamped tissues to confirm disease symptoms.

The existing biopsy sampling device generally comprises a biopsy puncture needle, a biopsy sampling forceps and the like, and in the case of the biopsy sampling forceps, the position of an endoscope is adjusted, the biopsy sampling forceps are adopted to cut partial lesion tissues at a single time, and the biopsy sampling forceps need to be taken out to obtain a collected sample in each operation. For example, patent CN201820287517.7 discloses a soft ureteroscope biopsy forceps, which comprises a soft tube, a handle, a push rod and a front end biopsy forceps; the flexible pipeline is arranged on the right side of the handle; the center of the flexible pipeline is provided with an axial round hole, and a slide way is arranged in the round hole; the push rod is arranged on the slideway and moves along the axial direction of the slideway; the front biopsy forceps are arranged at the right end of the push rod and comprise a puncture needle and hook forceps; the puncture needle comprises a needle head and a biopsy tissue storage tank, and the needle head is arranged at the right side of the biopsy tissue storage tank. The biopsy forceps have the advantages of simple instrument manufacturing process, direct-view operation, good safety and the like, but biopsy sampling forceps are required to be taken out for each biopsy, only one sample can be collected, the size of the sample is limited by the size of a biopsy tissue storage tank, partial tissues can be cut incompletely, and the tumor cells can be scattered and planted; and the tissue is cut by the hook forceps, so that the integrity of the sample tissue is greatly damaged, the cutting edge of the residual tissue is often torn and broken, the visual field of subsequent operation is influenced, repeated operation is required for biopsy sampling of large focus tissues or multiple focus tissues, and the working efficiency is low.

For example, the invention patent CN201922084987.0 discloses an endoscopic biopsy forceps capable of clamping a plurality of pathological tissues, which comprises a forceps body and forceps teeth, wherein the forceps body is communicated with a catheter, mounting seats are arranged on two sides of the forceps body, each forceps tooth is hinged with the mounting seat through a hinge, each hinge is connected with a pull wire, the pull wire sequentially penetrates through the forceps body and the catheter, an opening is further arranged at the upper end of the forceps body, and a filter screen is arranged at the joint of the opening and the forceps body. Pulling the forceps teeth through the pull wire, enabling the forceps teeth to be closed, namely clamping a piece of pathological tissue, then pulling the pull wire to enable the forceps teeth to be opened, enabling the pathological tissue to fall into the filter screen at the opening, achieving the effect that one-time operation can be conducted to clamp a plurality of samples, and improving the working efficiency. However, the clamped sample needs to be sucked onto the filter screen through the catheter, so that the inner diameter of the catheter needs to be set to be larger, otherwise, sample tissues can be crushed and deformed, pathological diagnosis is affected, and the method is not suitable for operating environments of some endoscopes (such as ureteroscopes, cystoscopes and the like) with narrow channels.

It is an object of the present invention to provide a biopsy sampling device that solves at least one of the above technical problems.

Disclosure of Invention

In view of the above analysis, the present invention proposes a biopsy sampling device to solve the deficiencies of the prior art.

The invention is mainly realized by the following technical scheme:

a biopsy sampling device, comprising:

a housing having an instrument channel extending from a first end of the housing to a second end of the housing;

the sampling main body is arranged in the instrument channel in a matching and penetrating mode and is provided with an accommodating space, and a sampling opening is formed in the accommodating space;

the negative pressure pipe is movably arranged on the sampling main body and is provided with a suction part correspondingly positioned at the second end, the suction part is arranged in the accommodating space, and a suction port positioned beside the sampling opening is arranged on the suction part;

and the cutting blade is movably arranged on the sampling opening so as to open or close the sampling opening.

Locate the sample main part with negative pressure pipe and cutting piece activity, when needs are organized the operation to the focus, focus tissue through the suction inlet suction part of negative pressure pipe, the cutting piece moves in order to close the sample opening in the sample main part, realize separating the tissue, make sample tissue drop to in the accommodation space, the cutting piece can be operated repeatedly, the incessant acquisition of fragmentary sample accessible negative pressure pipe of collection, great tissue sample can be along with the negative pressure pipe is taken out outside the sample main part together, need not to take out whole biopsy sampling device when adsorbing great tissue, only need insert the negative pressure pipe again can, the sampling time has been shortened, the application range of device has been enlarged.

Further, the cutting device also comprises a driving piece arranged on the cutting blade.

Further, the cutting blade is mounted on the negative pressure pipe.

Furthermore, be equipped with the guide way that is close to the sample opening setting in the sample main part, cutting piece slidable mounting is on the guide way.

Further, the sample main part includes hollow sleeve pipe, hollow sleeve pipe's one end is equipped with the shrouding, and the other end is equipped with the uncovered portion, one side of hollow sleeve pipe sets up the opening to at least, the second end form with cutting blade complex sample opening.

Further, the opening extends from the closing plate to the opening portion to form a sampling opening at the second end and a collecting opening at the first end.

Furthermore, a positioning seat is arranged on the cutting sheet, and the negative pressure pipe is installed on the positioning seat.

Further, the suction port is a bell mouth.

Further, a pressure regulator is mounted on the negative pressure pipe.

Further, a gap exists between the cutting blade and the sealing plate.

Compared with the prior art, the technical scheme of the invention has the beneficial effects that:

according to the biopsy sampling device provided by the invention, the cutting piece is adopted for cutting, the surface of a cut sample is relatively flat, the sight line interference on subsequent operation is avoided, the sampling opening is sealed through the cutting piece after cutting, the integrity of the sample is ensured, and the situation that in the process of transporting the sample by the negative pressure tube, sample fragments fall from the sampling opening to cause the scattering planting of tumor cells is avoided; for larger lesion tissues, sample tissues do not need to pass through a negative pressure tube, so that the requirement on the inner diameter of the negative pressure tube is reduced, the application range of the device is expanded, and the device is particularly suitable for biopsy operation in the use environments of ureteroscopy, cystoscope and the like; for a plurality of fragmentary focus tissues, through adjusting the cutting piece, the sample is sucked in vitro from the negative pressure tube in succession, need not take out biopsy sampling device, has shortened the sample time, has improved work efficiency.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the description below are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic structural diagram (one) of embodiment 1 of a biopsy sampling device provided in an embodiment of the present invention;

FIG. 2 is a schematic view of the biopsy sampling device of FIG. 1 with lesion tissue after cutting;

FIG. 3 is a schematic structural view of the cutting blade of FIG. 1;

FIG. 4 is a schematic structural diagram of example 2 of a biopsy sampling device provided in accordance with an example of the present invention;

fig. 5 is a schematic structural view of the negative pressure tube and the cutting blade in fig. 4.

The reference numbers are as follows:

1. the device comprises a shell, a 1a, an instrument channel, a 1b, a first end, a 1c, a second end, a 2, a sampling main body, a 2a, an accommodating space, a 2b, a sampling opening, a 2c, a guide groove, a 2d, a collecting opening, a 21, a hollow sleeve, a 21a, an open part, a 22, a sealing plate, a 3, a negative pressure pipe, a 31, a suction part, a 31a, a suction port, a 4, a cutting blade, a 5, a driving part, a 6, a positioning seat, a 7 and lesion tissues.

Detailed Description

In order that those skilled in the art will better understand the invention and thus more clearly define the scope of the invention as claimed, it is described in detail below with respect to certain specific embodiments thereof. It should be noted that the following description is only a few embodiments of the present invention, and the specific direct description of the related structures is only for the convenience of understanding the present invention, and the specific features do not, of course, directly limit the implementation scope of the present invention. Conventional choices and substitutions made by those skilled in the art in light of the present disclosure are to be considered within the scope of the present invention as claimed.

The invention is further described with reference to the following figures and specific examples.

Example 1

For the larger lesion tissues 7, in order to avoid the influence of the limited inner diameter of the negative pressure tube 3 on the application range, the tissue cannot be directly extracted from the negative pressure tube 3, and the vacuum negative pressure adsorption effect of the negative pressure tube 3 is selected to suck the sample tissues and take the sample tissues out of the body.

Referring to fig. 1, the biopsy sampling device provided by the present invention is particularly suitable for use in the operating environment of cystoscope and ureteroscope (for ureteroscope, the diameter of the lesion tissue 7 is less than or equal to 1.5 mm).

A biopsy sampling device comprising: the device comprises a shell 1, a sampling main body 2, a negative pressure pipe 3, a cutting blade 4 and a driving piece 5. The housing 1 has an instrument channel 1a, the instrument channel 1a extends from a first end 1b of the housing 1 to a second end 1c of the housing 1, the sampling body 2 is disposed through the instrument channel 1a and has an accommodating space 2a, and the accommodating space 2a is provided with a sampling opening 2b.

The negative pressure tube 3 is movably arranged on the sampling main body 2, the sampling operation can be continuously carried out, the sample tissue can be smoothly taken out by pumping out the negative pressure tube 3, the whole biopsy sampling device does not need to be withdrawn and entered for the second time, for the larger focal tissue 7, the excision operation of the focal tissue can be continuously carried out only by reinserting the negative pressure tube 3, the use burden of a patient can not be increased, the operation stability is improved, and the operation time is shortened.

The negative pressure tube 3 is provided with a suction part 31 correspondingly positioned at the second end 1c, the suction part 31 is arranged in the accommodating space 2a, the suction part 31 is provided with a suction port 31a positioned beside the sampling opening 2b, the negative pressure tube 3 is provided with a pressure regulator to control the negative pressure value, namely the vacuum degree, the pressure regulator is preferably a throttle valve, the vacuum degree in the negative pressure tube 3 is set in a grading way, different sample tissues (which are distinguished according to parameters such as sample size, sample tissue position and the like) can be obtained according to needs, the proper vacuum degree is selected, the negative pressure suction efficiency is balanced, and the completeness of the focus tissue 7 is ensured. Wherein, the suction part 31 is positioned at one end of the negative pressure tube 3 for sucking the lesion tissue.

Cutting blade 4 movable mounting is on sample opening 2b to open or close sample opening 2b, driving piece 5 is installed on cutting blade 4, is convenient for carry out manual regulation to cutting blade 4 in vitro.

In this embodiment, the shape of the cutting edge of the cutting blade 4 is not limited as long as the cutting operation can be realized, and the cutting edge is preferably arranged obliquely, so that the focal tissue 7 can be conveniently and rapidly cut off; as shown in fig. 3, the driving member 5 is rod-shaped or handle-shaped, and is detachably connected to the cutting blade 4, so as to facilitate replacement of the cutting blade 4, specifically, the driving member is in the form of a pin connection or a snap connection.

The positions of the negative pressure tube 3 and the cutting blade 4 can be respectively and independently adjusted, the position of the negative pressure tube 3 relative to the sampling opening 2b can be seen under an endoscope by adjusting the position of the negative pressure tube 3 in the accommodating space 2a, and the corresponding negative pressure value is adjusted (adjusted according to the size of sample tissues to be extracted), so that the adsorption operation is convenient; by adjusting the position of the cutting blade 4 to adjust the size of the sampling opening 2b, different sizes of sample tissues to be extracted are obtained.

Preferably, the sampling body 2 includes a hollow sleeve 21, one end of the hollow sleeve 21 is provided with a closing plate 22, the other end is provided with an opening portion 21a, and one side of the hollow sleeve 21 is provided with an opening so that at least the second end 1c forms a sampling opening 2b to be engaged with the cutting blade 4. The sample tissue is adsorbed through the negative pressure tube 3, the cutting piece 4 moves to the sampling opening 2b covering the second end 1c, so that the accommodating space 2a of the sampling main body 2 forms a relatively closed space in vivo, the cut sample tissue is smoothly conveyed out of the body through the negative pressure tube 3, and meanwhile, the negative pressure cannot be damaged by the tissue which is not cut in the body.

In this embodiment, the suction port 31a is disposed opposite to the sealing plate 22, so as to facilitate sucking more tissues into the accommodating space 2a and prevent the sample tissues cut by the cutting blade 4 from being too small. Hollow sleeve 21 and shrouding 22 integrated into one piece, guide way 2c is located between opening and the shrouding 22 for there is the space between shrouding 22 and the cutting blade 4, avoids haring the edge of a knife, can observe the position of cutting blade 4 under the scope, avoids the mistake to damage the tissue. The opening extends from the closing plate 22 to the opening portion 21a to form a sampling opening 2b at the second end 1c and a collecting opening 2d at the first end 1b, the sampling opening 2b and the collecting opening 2d are separated by the cutting blade 4, and when the cutting blade 4 closes the sampling opening 2b, only the collecting opening 2d of the hollow sleeve 21 is in an open state.

Sample main part 2's design has reduced sample main part 2's volume, and driving piece 5, negative pressure pipe 3 stretch out from open portion 21a simultaneously, take out negative pressure pipe 3 and sample tissue from collecting opening 2d more easily, further guarantee sample tissue's integrality, have reduced the operation degree of difficulty. Wherein, accommodation space 2a is the storage tank, and hollow sleeve 21, storage tank and shrouding 22's cross-section is close half-circular arc, guarantees sample opening 2 b's width, reduces the volume that hollow sleeve 21 occupy, and the focus tissue 7 is held to the more stable of the negative pressure pipe 3 of being convenient for, makes things convenient for cutting piece 4 to cut.

Wherein, suction port 31a is located the outer tip of negative pressure pipe 3, and negative pressure pipe 3 can be the cylinder tubulose, and the terminal surface of suction port 31a is the horn mouth shape, and the inner wall of negative pressure pipe 3 is smooth not stained with, and for the removal of making things convenient for negative pressure pipe 3, the external diameter of negative pressure pipe 3 is less than the radius of accommodation space 2 a. The shape of the negative pressure tube 3 is not limited to the above structure, and may be adapted to the shape of the accommodating space 2a, so as to utilize the inner space of the accommodating space 2a to the maximum extent and improve the suction efficiency of the negative pressure tube 3.

In this embodiment, be equipped with the guide way 2c that is close to sample opening 2b and sets up on sample main part 2, preferred setting is on sample opening 2 b's double-phase inside wall, cutting piece 4 slidable mounting is on guide way 2c, make its length direction along sample main part 2 remove, guide way 2c extends to shrouding 22 from uncovered portion 21a, conveniently install cutting piece 4, lead to its moving direction simultaneously, the mistake is organized into the damage to the group when avoiding operating, cutting piece 4 seals sample opening 2b after the cutting finishes, avoid the sample piece to drop from sample opening 2b, the safety of assurance device use, reliability.

As shown in fig. 2, in use, the biopsy sampling device is close to the focal tissue 7, the driving handle is held at the first end 1b of the housing 1 to move towards the outside of the instrument channel 1a, the cutting blade 4 is adjusted to open the sampling opening 2b to a proper length (determined according to the size of the sample tissue to be cut), the containing groove at the sampling opening 2b covers part of the focal tissue 7, the driving handle is held at the first end 1b of the housing 1 to move towards the inside of the instrument channel 1a, the cutting blade 4 is adjusted to cut the focal tissue 7 at the sampling opening 2b, then the sampling opening 2b is closed, the sample tissue is collected at the collecting opening 2d, the sampling is performed again if necessary, the negative pressure tube 3 is inserted into the hollow sleeve 21 to perform the sampling again, and the housing 1 is taken out after the sampling is completed.

Example 2

As for a plurality of fragmentary focal tissues 7, the fragmentary focal tissues can be directly extracted through the negative pressure tube 3, as shown in figures 4 and 5, the invention also provides another biopsy sampling device, and the cutting blade 4 is arranged on the negative pressure tube 3. Cutting blade 4 can wholly remove along the length direction of sample main part 2 with negative pressure tube 3, and negative pressure tube 3 is the cylinder tubulose, and the terminal surface of suction opening 31a is horn mouth shape, and the inner wall of negative pressure tube 3 is smooth not stained with, adjusts the negative pressure value of negative pressure tube 3 (theoretically should be less than the negative pressure value of embodiment 1, adjusts according to the size of the sample tissue that needs to draw), is convenient for carry the sample tissue under negative pressure state.

On the biopsy sampling aiming at the fragmentary focus tissues, the operation can be continuously performed only by operating the stroke of the cutting blade 4 without taking out the negative pressure tube 3 until enough sample tissues are collected, so that the operation time can be effectively shortened, and the operation efficiency and the success rate of pathological diagnosis are improved.

Preferably, the cutting blade 4 is provided with a positioning seat 6, and the negative pressure tube 3 is installed on the positioning seat 6.

In this embodiment, the positioning seat 6 is arranged on the back side of the cutting blade 3, the positioning seat 6 is provided with a clamping groove, and the negative pressure tube 3 is welded on the clamping groove.

The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.

Claims (10)

1. A biopsy sampling device, comprising:

a housing (1) having an instrument channel (1 a), the instrument channel (1 a) extending from a first end (1 b) of the housing (1) to a second end (1 c) of the housing (1);

the sampling main body (2) is arranged in the instrument channel (1 a) in a penetrating mode in a matching mode and is provided with an accommodating space (2 a), and a sampling opening (2 b) is formed in the accommodating space (2 a);

the negative pressure pipe (3) is movably arranged on the sampling main body (2) and is provided with a suction part (31) correspondingly positioned at the second end (1 c), the suction part (31) is arranged in the accommodating space (2 a), and a suction port (31 a) positioned at the side of the sampling opening (2 b) is arranged on the suction part (31);

and the cutting blade (4) is movably arranged on the sampling opening (2 b) so as to open or close the sampling opening (2 b).

2. The biopsy sampling device of claim 1, wherein: the cutting device also comprises a driving piece (5) arranged on the cutting blade (4).

3. The biopsy sampling device of claim 1, wherein: the cutting blade (4) is arranged on the negative pressure pipe (3).

4. The biopsy sampling device defined in any one of claims 1-3, wherein: the sampling main body (2) is provided with a guide groove (2 c) which is close to the sampling opening (2 b), and the cutting blade (4) is slidably arranged on the guide groove (2 c).

5. The biopsy sampling device of claim 4, wherein: the sampling main body (2) comprises a hollow sleeve (21), one end of the hollow sleeve (21) is provided with a sealing plate (22), the other end of the hollow sleeve (21) is provided with an opening part (21 a), and one side of the hollow sleeve (21) is provided with an opening so as to be less than the second end (1 c) to form a sampling opening (2 b) matched with the cutting blade (4).

6. The biopsy sampling device of claim 5, wherein: the opening extends from the closure plate (22) to an open portion (21 a) to form a sampling opening (2 b) at the second end (1 c) and a collection opening (2 d) at the first end (1 b).

7. The biopsy sampling device of claim 3, wherein: the cutting blade (4) is provided with a positioning seat (6), and the negative pressure tube (3) is arranged on the positioning seat (6).

8. The biopsy sampling device of any one of claims 2, 3, and 7, wherein: the suction opening (31 a) is a bell mouth.

9. The biopsy sampling device of claim 1, wherein: and a pressure regulator is arranged on the negative pressure pipe (3).

10. The biopsy sampling device of claim 5, wherein: and a gap is reserved between the cutting blade (4) and the sealing plate (22).

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