CN115154521A

CN115154521A - Composition and preparation for treating psoriasis caused by external cold and internal heat and preparation method

Info

Publication number: CN115154521A
Application number: CN202211015153.4A
Authority: CN
Inventors: 刘爱民
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-08-23
Filing date: 2022-08-23
Publication date: 2022-10-11
Anticipated expiration: 2042-08-23
Also published as: CN115154521B

Abstract

The invention discloses a composition and a preparation for treating psoriasis caused by external cold and internal heat and a preparation method thereof, belonging to the technical field of Chinese herbal medicines. The preparation is prepared from herba Ephedrae, radix Saposhnikoviae, cornu Bubali, radix rehmanniae, radix Arnebiae, fructus Gardeniae and flos Sophorae Immaturus. In the recipe, ephedra herb and ledebouriella root, radix sileris, with pungent and warm natured drugs and cold dispelling effects, xuan Qi are used for inducing hair orifices to dissipate internal heat; the buffalo horn, the radix rehmanniae, the lithospermum, the gardenia and the raw sophora flower cool and clear heat in the interior, so that internal heat or blood heat is dissipated from the inside and the outside, and the effect is quicker compared with the common simple blood cooling and heat clearing method. Therapeutic method: pungent and warm natured drugs dispel cold, clear heat and cool blood. The main indications of the prescription are as follows: when the body is scaly papules and erythema in autumn and winter or after the cold in autumn and winter, the skin is damaged more by extending the trunk and limbs. It is accompanied by dry mouth and dry stool, and can be taken frequently. Red tongue with thin or yellow coating and no deficiency in the pulse. The prescription is used for treating psoriasis caused by external cold and internal heat (cold wrapped fire).

Description

Composition and preparation for treating psoriasis caused by external cold and internal heat and preparation method

Technical Field

The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a composition and a preparation for treating psoriasis caused by external cold and internal heat and a preparation method thereof.

Background

Psoriasis, commonly known as "psoriasis", is a common chronic inflammatory skin disease that is prone to recurrence, characterized by red papules or plaques covered with multiple silvery-white scales. The incidence of the disease is the most in the young and the strong, the incidence of the disease is more in males than in females, the incidence of the disease is more in the north than in the south, the disease is easy to develop or aggravate in autumn and winter, and the disease is relieved in summer.

The disease is considered in western medicine, and the etiology of the disease is related to heredity, infection, metabolic disorder, immune dysfunction, endocrine disorder, mental trauma, trauma or operation and the like. Psoriasis was initially recognized in western medicine as an epidermal disease caused by biochemical or cellular defects of keratinocytes. In the early 80's of the 20 th century, several biochemical mediators, enzymes and pathways were found to be abnormal in psoriasis, including cAMP, eicosanoids, protein kinase C, phospholipase C, polyamines, transforming growth factor alpha, and the like. The conventional western medicines are also hormone medicines or cyclosporine medicines and the like, the medicines have high treatment efficiency but have unsatisfactory effect, and long-term use of the medicines can not only cause drug resistance of the skin of a patient, but also even aggravate diseases.

The three diseases of classic psoriasis, namely 'blood heat', 'blood dryness' and 'blood stasis', are the results of pathological changes, and a plurality of prescriptions are also treated in a symptomatic way.

The related technical scheme discloses the combination of 25-35 parts of rhubarb root and rhizome, 25-35 parts of golden larch bark, 25-35 parts of common burreed rhizome, 25-35 parts of zedoary, 15-25 parts of safflower, 25-35 parts of red sage root, 25-35 parts of bletilla, 15-25 parts of pseudo-ginseng, 35-45 parts of wild chrysanthemum flower, 10-20 parts of pericarpium zanthoxyli and 25-35 parts of Chinese mugwort leaf, thus achieving the purposes of promoting blood circulation, removing blood stasis, killing parasites, relieving itching, clearing away heat and toxic materials, relieving swelling and alleviating pain. The prescription adopts a mode of 'symptomatic medication', and treats the disease of 'blood stasis' by activating blood and dissolving stasis. Meanwhile, the prescription carries out a certain treatment mode on the surface layer of the skin by using a bathing mode. The mode has slow response and poor effect on the treatment of psoriasis.

In traditional Chinese medicine, the syndrome of external cold and internal heat (cold wrapped fire) refers to patients with heat or blood heat in their organism, and the disease is mostly caused by the close of hair orifices after autumn and winter, no external heat is dissipated, and the internal heat is dissipated in a skin-peeling manner to form erythema and scale.

The traditional Chinese medicine has a long time for treating psoriasis, but the existing traditional Chinese medicine treatment scheme is mostly 'symptomatic medicine administration', few medicine formulas aiming at 'medicine administration for the reasons' are available, and the traditional Chinese medicine also has an excellent treatment result.

Disclosure of Invention

The invention aims to provide a composition and a preparation for treating psoriasis caused by external cold and internal heat and a preparation method thereof, and aims to solve the technical problem that the prior art rarely utilizes 'medicine administration' which is an effective prescription for treating psoriasis caused by external cold and internal heat (cold-wrapped fire). The preparation is a treatment method of dispelling cold with pungent and warm natured drugs, clearing heat and cooling blood, and can treat symptoms of squamous pimple and erythema per autumn and winter or attack after autumn and winter cold, and more skin damage of trunk and limbs extending. It is accompanied by dry mouth and dry stool, and can be taken as usual. Red tongue with thin or yellow coating and no deficiency symptoms in the pulse.

The invention is realized by the following technical scheme:

the composition for treating psoriasis caused by external cold and internal heat is prepared from the following raw materials in parts by weight:

2-20 parts of ephedra, 6-22 parts of divaricate saposhnikovia root, 6-60 parts of buffalo horn, 3-30 parts of radix rehmanniae, 6-60 parts of lithospermum, 3-30 parts of cape jasmine and 3-30 parts of raw sophora flower.

Square solution: in the recipe, ephedra and ledebouriella root, radix sileris, with pungent and warm natured drugs and cold dispelling effects, xuan Qi are used for inducing hair orifices to dissipate internal heat; the buffalo horn, the radix rehmanniae, the lithospermum, the gardenia and the raw sophora flower cool and clear heat in the interior, so that internal heat or blood heat is dissipated from the inside and the outside, and the effect is quicker compared with the common simple blood cooling and heat clearing method. Therapeutic method: pungent and warm natured drugs dispel cold, clear heat and cool blood.

Preferably, the composition is mainly prepared from the following raw materials in parts by mass:

5-15 parts of ephedra herb, 8-18 parts of divaricate saposhnikovia root, 15-45 parts of buffalo horn, 7-22 parts of rehmannia root, 15-45 parts of sinkiang arnebia root, 7-22 parts of cape jasmine fruit and 7-22 parts of raw sophora flower.

8-12 parts of ephedra, 10-15 parts of divaricate saposhnikovia root, 24-36 parts of buffalo horn, 12-18 parts of radix rehmanniae, 24-36 parts of lithospermum, 12-18 parts of gardenia and 12-18 parts of raw sophora flower.

10 parts of ephedra, 12 parts of divaricate saposhnikovia root, 30 parts of buffalo horn, 15 parts of radix rehmanniae, 30 parts of lithospermum, 15 parts of gardenia and 15 parts of raw sophora flower.

Ma Huang, the name of Chinese medicine. Is the grass stem of Ephedra sinica SinicaStapf, ephedra intermedia Schrenk et C.A.Mey, or Ephedra equisetifolia equiseti Bge. Has effects of inducing sweat, relieving exterior syndrome, dispersing lung qi, relieving asthma, and inducing diuresis to alleviate edema. It can be used for treating wind-cold type common cold, cough, asthma, and edema due to wind-damp evil. Pungent, slightly bitter and warm in nature; it enters lung and bladder meridians. The product contains ephedrine as main ingredient, and small amount of pseudoephedrine, volatile oil, flavonoids, and ephedra polysaccharide.

Ledebouriellae, the name of Chinese medicine. Is root of Saposhnikovia divaricata (Turcz.) Schischk. Has effects of dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm. Can be used for treating exterior syndrome due to exogenous pathogenic factor, rubella, pruritus, rheumatalgia, and tetanus. Pungent and sweet in flavor and slightly warm in nature; it enters bladder and liver meridians. The product contains volatile oil, mannitol, beta-sitosterol, picroside, phenols, polysaccharides, organic acids, etc. The product has antipyretic, antiinflammatory, tranquilizing, analgesic, anticonvulsive, and antiallergic effects. The divaricate saposhnikovia root fresh juice has a certain antibacterial effect on pseudomonas aeruginosa and staphylococcus aureus, the decoction has different degrees of inhibition effects on dysentery bacillus, hemolytic streptococcus and the like, and the decoction has the effect of enhancing the phagocytic function of abdominal cavity macrophages of mice.

Buffalo horn, name of traditional Chinese medicine. Is horn of Bubalusballalis Linnaeus belonging to Bubalusbubalis of Bubalus of Bovidae, and is a substitute for cornu Rhinocerotis. Has the effects of clearing heat, cooling blood, removing toxic substances and arresting convulsion. It can be used for treating epidemic febrile disease, hyperpyrexia, delirium, infantile convulsion, mania, blood heat, macula, hematemesis, epistaxis, carbuncle, suppurative sore, and sore throat. Bitter taste and cold nature; it enters heart and liver meridians. The extract and decoction have cardiotonic effect; the injection has the effects of lowering blood pressure, increasing platelet count, shortening blood coagulation time, reducing capillary permeability, resisting inflammation, relieving convulsion and fever, protecting mice attacked by Escherichia coli and beta hemolytic streptococcus, and exciting pituitary-adrenal cortex system. The product contains cholesterol, peptides, various amino acids, and various trace elements.

Radix rehmanniae is dried root tuber of rehmannia glutinosa Libosch of Scrophulariaceae. Mainly produced in Henan. Removing rhizoma Phragmitis, fibrous root and silt, and slowly baking rehmanniae radix to about eight dry parts to obtain radix rehmanniae. According to traditional Chinese medicine, the radix rehmanniae is sweet and cold in property, enters heart, liver and kidney channels, has the functions of clearing heat and cooling blood, and nourishing yin and promoting the production of body fluid, and is used for treating heat entering nutrient blood, warm toxicity and macula, hematemesis and epistaxis, fever and yin impairment, crimson tongue and polydipsia, body fluid injury constipation, yin deficiency fever, bone steaming and internal heat and diabetes. Clearing heat and cooling blood: rehmannia is sweet and cold in nature and moist, bitter and cold in property and capable of clearing heat, cooling blood, stopping bleeding, nourishing yin and promoting fluid production, and can be used for treating fever, vexation, thirst, poor spirit, dry mouth and the like caused by heat entering nutrient and blood in warm diseases, hematemesis, nosebleed and the like caused by warm toxicity and macula. Nourishing yin and promoting the production of body fluid: rehmannia has the effects of clearing heat and nourishing yin, and promoting the production of body fluid to quench thirst, and can be used for improving dark red tongue, polydipsia and constipation caused by intestinal dryness due to fever yin impairment. Rehmannia enters kidney meridian and can nourish yin to reduce fire, so that it can be used for treating hectic fever due to kidney yin deficiency (self-sensation of fever, heat from inside to outside of bone), night sweat (abnormal night sweating), etc.

Arnebia root, radix Arnebiae, name of Chinese medicine. Is root of arnebia euchroma (Royle) Johnst, lithospermum erythrorhizon A. Guttata Bunge, lithospermum erythrorhizon Sieb. Et Zucc. Has the effects of clearing heat, cooling blood, promoting blood circulation, removing toxic substances and promoting eruption. It can be used for treating warm diseases, blood heat and toxic materials, purple black macula, measles without adequate eruption, pyocutaneous disease, eczema, and scald due to hot water or fire. Sweet, salty and cold in nature; it enters heart and liver meridian. It has antifertility and antipyretic effects.

Cape jasmine, the name of traditional Chinese medicine. Is dried mature fruit of Gardenia jasminoides Ellis of Gardenia of Rubiaceae. Has the effects of purging fire, relieving restlessness, clearing heat, promoting diuresis, cooling blood and removing toxic substances. It can be used for treating vexation, jaundice due to damp-heat, stranguria with blood, hematemesis, epistaxis, conjunctival congestion, swelling and pain, and pyocutaneous disease due to fire toxin. Bitter taste and cold nature; it enters heart, lung and triple energizer meridians.

Raw flos Sophorae Immaturus is dried flower and bud of Sophora japonica L of Leguminosae. Produced in most areas of the country. The traditional medicine considers that the sophora flower is bitter and slightly cold in property, enters liver and large intestine channels, has the functions of cooling blood and stopping bleeding, and clearing liver and purging fire, and is used for treating hematochezia, hemorrhoidal bleeding, bloody flux, metrorrhagia and metrostaxis, hematemesis, epistaxis, liver heat and conjunctival congestion, headache and dizziness. Blood cooling and hemostasis, i.e. the sophora flower is bitter in taste, cold and cool in nature, can clear heat in blood system and has the function of cooling blood and hemostasis. Therefore, it can be used for treating blood heat bleeding, hemorrhoid bleeding and hematochezia caused by large intestine fire or damp-heat accumulation. Clearing liver fire, flos Sophorae Immaturus can clear liver heat with its bitter flavor and cold property, entering liver meridian, and has the function of clearing liver fire. Therefore, can be used for treating symptoms such as headache, conjunctival congestion, vertigo and the like caused by liver fire flaming up. Flos Sophorae Immaturus contains rutin, and has low content after blooming. Triterpene saponin is obtained from the dried flower bud, and betulin, sophoricoside, glucose and glucuronic acid are obtained after hydrolysis. Flos Sophorae Immaturus extract contains deoxyribose, and C, wherein the deoxyribose is flavone different from rutin, and the B and C are sterols. It also contains quercetin, quercetin tannin, and a large amount of vitamin A substances.

A preparation for treating psoriasis caused by external cold and internal heat is prepared from a traditional Chinese medicine composition for treating psoriasis caused by external cold and internal heat.

A preparation method of a preparation for treating psoriasis caused by external cold and internal heat comprises the following steps:

selecting ephedra, radix sileris, buffalo horn, radix rehmanniae, lithospermum, gardenia and raw sophora flower as raw materials according to corresponding parts by weight, mixing the raw materials and then processing.

Preferably, the treatment after mixing of the raw materials comprises: mixing the above raw materials, and decocting in water to obtain decoction;

the ratio of the feed to the liquid is 1:3-5.

Preferably, the number of times of decoction is 2-3, and the duration of decoction is 20-30 min/time.

Preferably, the treatment after mixing of the raw materials comprises: mixing the above raw materials, extracting with water to obtain raw material extract powder, and adding solidifying agent to obtain pill;

the mass ratio of the raw material extraction powder to the solidifying agent is 1:0.2-0.4.

Preferably, the solidifying agent comprises honey and/or beeswax.

Honey, name of traditional Chinese medicine. Is prepared from Apis cerana Fabr or Apis mellifera L. Has effects of invigorating spleen, relieving spasm, moistening lung, relieving cough, and loosening bowel to relieve constipation. Can be used for treating weakness of spleen and stomach, abdominal pain, dry cough due to lung deficiency, chronic cough due to lung deficiency, constipation due to intestinal dryness, etc.

Yellow wax, name of traditional Chinese medicine. Is block-shaped substance prepared by artificially refining wax secreted by Apicerana Fabry. Has effects in removing toxic materials, promoting granulation, relieving dysentery, stopping bleeding, and relieving pain. It can be used for treating carbuncle, cellulitis, carbuncle, ulcer, acute cardialgia, dysentery, purulent blood, chronic diarrhea, fetal movement, spermatorrhea, and leukorrhagia.

Compared with the prior art, the invention at least has the following technical effects:

the invention provides a preparation for treating psoriasis caused by external cold and internal heat, which is prepared from ephedra, ledebouriella root, buffalo horn, dried rehmannia root, alkanna tinctoria, cape jasmine and sophora flower.

In the recipe, ephedra herb and ledebouriella root, radix sileris, with pungent and warm natured drugs and cold dispelling effects, xuan Qi are used for inducing hair orifices to dissipate internal heat; the buffalo horn, the rehmannia root, the lithospermum, the gardenia and the raw sophora flower cool and clear heat in the interior, so that the internal heat or the blood heat is dissipated from the internal and the external ways, and the effect is quicker than that of the general method of simply cooling and clearing heat from blood. Therapeutic methods: pungent and warm natured herbs dispel cold, clear heat and cool blood.

The main indications of the prescription are as follows: when the body is scaly papules and erythema in autumn and winter or after the cold in autumn and winter, the skin is damaged more by extending the trunk and limbs. It is accompanied by dry mouth and dry stool, and can be taken frequently. Red tongue with thin or yellow coating and no deficiency in the pulse.

The prescription is used for treating psoriasis caused by external cold and internal heat (cold wrapped fire).

Drawings

Figure 1 is a schematic diagram of a back of a patient 1 before treatment;

fig. 2 shows a schematic view of the abdomen of the patient 1 before treatment;

figure 3 shows a schematic view of the back of the patient 1 after treatment;

fig. 4 shows a schematic view of the abdomen of the patient 1 after treatment.

Detailed Description

Embodiments of the present invention will be described in detail with reference to the following examples, but those skilled in the art will understand that the following examples are merely illustrative of the present invention and should not be construed as limiting the scope of the present invention, and that the specific conditions not specified in the examples are carried out according to conventional conditions or conditions suggested by the manufacturer, and that the reagents or equipment used are not specified by the manufacturer, and are all conventional products available through commercial purchase.

The following describes in detail specific embodiments of the present invention. It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are given by way of illustration and explanation only, not limitation.

Example 1:

a method for preparing a decoction for treating psoriasis caused by external cold and internal heat comprises the following steps:

according to the corresponding parts by weight, 200 g of ephedra, 600 g of divaricate saposhnikovia root, 600 g of buffalo horn, 300 g of rehmannia root, 600 g of lithospermum, 300 g of gardenia and 300 g of raw sophora flower are selected as raw materials, and after the raw materials are mixed, 14500 g of water is added to decoct for 2 times, 30min each time, so as to obtain decoction.

A method for preparing a pill for treating psoriasis caused by external cold and internal heat comprises the following steps:

200 g of ephedra, 600 g of divaricate saposhnikovia root, 600 g of buffalo horn, 300 g of rehmannia root, 600 g of lithospermum, 300 g of gardenia and 300 g of raw sophora flower are selected as raw materials according to corresponding mass parts, and after the raw materials are mixed, water extraction is carried out to obtain raw material extraction powder, 580 g of honey is added, and then pills are obtained.

The process for extracting the raw material powder by water extraction comprises the following steps:

adding 1000-2000mL of 60-80% ethanol solution into 1000g of mixed raw material components, performing ultrasonic extraction for 40-55 min under the conditions of power of 300-400W and temperature of 50-60 ℃, collecting an extracting solution, and then performing centrifugation and reduced pressure concentration to recover the solvent to obtain the raw material extract. And then spray-drying the extracting solution to obtain raw material extracting powder.

Example 2:

selecting 2000 g of ephedra, 2200 g of divaricate saposhnikovia root, 6000 g of buffalo horn, 3000 g of radix rehmanniae, 6000 g of lithospermum, 3000 g of gardenia and 3000 g of raw sophora flower as raw materials according to corresponding parts by weight, mixing the raw materials, adding 75600 g of water, and decocting for 3 times, each time for 20min to obtain decoction.

selecting 2000 g of ephedra, 2200 g of divaricate saposhnikovia root, 6000 g of buffalo horn, 3000 g of radix rehmanniae, 6000 g of lithospermum, 3000 g of gardenia and 3000 g of raw sophora flower as raw materials according to corresponding mass parts, mixing the raw materials, extracting by water to obtain raw material extract powder, adding 10080 g of yellow wax, and obtaining the pills.

The process of extracting the raw material powder by water extraction comprises the following steps:

Example 3:

according to the corresponding weight parts, 500 g of ephedra herb, 800 g of divaricate saposhnikovia root, 1500 g of buffalo horn, 700 g of rehmannia root, 1500 g of sinkiang arnebia root, 700 g of gardenia and 700 g of raw sophora flower are selected as raw materials, and after the raw materials are mixed, 32000 g of water is added for decocting for 3 times, 20min each time, so as to obtain the decoction.

according to the corresponding parts by weight, 500 g of ephedra, 800 g of divaricate saposhnikovia root, 1500 g of buffalo horn, 700 g of radix rehmanniae, 1500 g of lithospermum, 700 g of gardenia and 700 g of raw sophora flower are selected as raw materials, the raw materials are mixed and then are extracted by water to obtain raw material extraction powder, 2560 g of honey is added, and the pills are obtained.

adding 1000-2000mL of 60-80% ethanol solution into 1000g of mixed raw material components, carrying out ultrasonic extraction for 40-55 min under the conditions that the power is 300-400W and the temperature is 50-60 ℃, collecting an extracting solution, and then carrying out centrifugation and reduced pressure concentration to recover the solvent to obtain the raw material extract. And then spray-drying the extracting solution to obtain raw material extracting powder.

Example 4:

selecting 1500 g of ephedra, 1800 g of divaricate saposhnikovia root, 4500 g of buffalo horn, 2200 g of radix rehmanniae, 4500 g of lithospermum, 2200 g of gardenia and 2200 g of raw sophora flower as raw materials according to corresponding parts by weight, mixing the raw materials, adding 56700 g of water, and decocting for 2 times, each time for 30min to obtain decoction.

selecting 1500 g of ephedra, 1800 g of divaricate saposhnikovia root, 4500 g of buffalo horn, 2200 g of radix rehmanniae, 4500 g of lithospermum, 2200 g of gardenia and 2200 g of raw sophora flower as raw materials according to corresponding mass parts, mixing the raw materials, extracting with water to obtain raw material extract powder, adding 3780 g of beeswax, and obtaining the pill.

Example 5:

according to the corresponding weight parts, 800 g of ephedra, 1000g of divaricate saposhnikovia root, 2400 g of buffalo horn, 1200 g of rehmannia root, 2400 g of lithospermum, 1200 g of gardenia and 1200 g of raw sophora flower are selected as raw materials, and after the raw materials are mixed, 30600 g of water is added to decoct for 3 times, each time for 20min, so as to obtain decoction.

selecting 800 g of ephedra, 1000g of divaricate saposhnikovia root, 2400 g of buffalo horn, 1200 g of radix rehmanniae, 2400 g of lithospermum, 1200 g of gardenia and 1200 g of raw sophora flower as raw materials according to corresponding mass parts, mixing the raw materials, carrying out water extraction to obtain raw material extraction powder, adding 2040 g of honey, and obtaining the pills.

Example 6:

selecting 1200 g of ephedra, 1500 g of divaricate saposhnikovia root, 3600 g of buffalo horn, 1800 g of rehmannia root, 3600 g of lithospermum, 1800 g of gardenia and 1800 g of raw sophora flower as raw materials according to corresponding mass parts, mixing the raw materials, adding 45900 g of water, and decocting for 3 times, each time for 20min to obtain decoction.

selecting 1200 g of ephedra, 1500 g of divaricate saposhnikovia root, 3600 g of buffalo horn, 1800 g of rehmannia root, 3600 g of lithospermum, 1800 g of gardenia and 1800 g of raw sophora flower as raw materials according to corresponding mass parts, mixing the raw materials, carrying out water extraction to obtain raw material extraction powder, adding 3060 g of honey, and obtaining the pill.

Example 7:

selecting 1000g of ephedra, 1200 g of divaricate saposhnikovia root, 3000 g of buffalo horn, 1500 g of radix rehmanniae, 3000 g of lithospermum, 1500 g of gardenia and 1500 g of raw sophora flower as raw materials according to corresponding parts by weight, mixing the raw materials, adding 38100 g of water, and decocting for 3 times, each time for 20min to obtain decoction.

selecting 1000g of ephedra, 1200 g of divaricate saposhnikovia root, 3000 g of buffalo horn, 1500 g of radix rehmanniae, 3000 g of lithospermum, 1500 g of gardenia and 1500 g of raw sophora flower as raw materials according to corresponding mass parts, mixing the raw materials, extracting with water to obtain raw material extract powder, adding 2540 g of beeswax to obtain the pills.

Clinical cases:

patient 1: male, 40 years old, han nationality, zheng Zhou, 4 months and 24 days of first diagnosis in 2019. The main complaints are: the whole body is scattered on the squamous erythema and pimple for more than 10 years, and the weight is increased for 1 year. The current medical history: the patients have no obvious reason to cause the disease before more than 10 years, have been diagnosed in a certain three hospitals in Zheng Zhou, and have uncertain specific medication and poor effect. The skin damage is serious in winter and mild in summer for 10 years, and the process is repeated. Before 1 year, no obvious cause or aggravation exists, and the self-conscious effect is mild when the Chinese medicament is taken orally and externally used for compound clobetasol propionate ointment and the like in a certain three hospitals. The symptoms are as follows: the whole body has the symptoms of dripping squamous erythema, pimple with itching, much outside of the limbs, sleep-receiving, loose stool, small stool, irritability, dry mouth without desire for drinking, pale tongue, reddened tip, thin and white fur and weak pulse. And (3) diagnosis: and (3) Western diagnosis: psoriasis. Traditional Chinese medicine diagnosis: and (4) the psoriasis. Syndrome type: yang deficiency with external cold, spleen deficiency with liver hyperactivity, and skin stagnant heat. Therapeutic method: warming yang to dispel cold, invigorating spleen to regulate liver, cooling blood and clearing heat. The product obtained from example 7 was used, 2 times per day. And (2) second diagnosis: after the medicine is taken, most of the skin lesions disappear, the stool returns to normal, the tongue is pale, the coating is thin and white, the pulse is weak on the right and is flat on the left. Three diagnoses: after the medicine is applied, most of the skin lesions disappear, the residual skin lesions are thick, dark and red, the stool is normal, the tongue is pale, the tongue coating is thin and white, and the pulse is deep. Four diagnosis: the skin loss basically subsides, several dark red papules remain, loose stools, a pale tongue with teeth marks on the edges, a thin and white coating, and a deep and slightly wiry pulse. The exterior cold is removed and the stagnated heat of the skin is basically removed, so the method is to warm and tonify the spleen and stomach, sooth the liver, clear heat, cool blood and remove toxicity.

The disease course of the patient is as long as 10 years, the pathogenesis of the patient is complex, and the disease is not only mixed of deficiency and excess, but also related to a plurality of internal organs. Severe winter with severe skin damage and mild summer, pale tongue with weak pulse, which is the condition of yang deficiency and external cold; loose stool, dry mouth without desire for drinking, spleen deficiency with dampness; the skin lesion is in the shape of drops, red in color, red in tip of tongue and with the existence of stagnant heat in skin; the spleen-qi is irritable and irritative, which is the symptom of stagnated heat in the liver meridian. The origin of the disease of the patients with the slight thought lies in the deficient yang-qi of the body, the natural deficiency of defensive yang, the easy invasion of exogenous pathogenic wind-cold, the contraction and stagnation of the cold, the wind-cold pathogen tends to block the body surface, the failure of the yang-qi of the skin surface to reach, the aggravation of the stagnated heat of the skin, and the skin damage attack. Therefore, the patients in this example are distinguished by yang deficiency with external cold, spleen deficiency with liver hyperactivity and skin stasis and heat, and the treatment is performed by warming yang for dispelling cold, invigorating spleen for soothing liver, clearing heat and cooling blood. If the patient only takes bitter and cold herbs, or the disease is improved in the early stage, but the middle-yang will be damaged for a long time, which leads to the occurrence of variable syndrome. And a doctor with slight brightness sees that yang deficiency and blood heat coexist in the body, adopts a method of warming yang qi and clearing heat and cooling blood, neglects the existence of pathogenic factors of wind cold to block the exterior disease mechanism, does not release the exterior cold to block the exterior of the muscle, is difficult to communicate between qi activities in the body and the outside of the body even if the yang is warmed, is difficult to remove the skin stagnated heat, does not get the disease state better, even aggravates the skin stagnated heat, and has the phenomenon of skin damage aggravation. Therefore, the best treatment method for the patient is to use both cold and warm, to coordinate the exterior and interior and to treat both the principal and secondary aspects of the disease.

The back condition before treatment is shown in fig. 1; FIG. 2 shows an abdominal condition before treatment; FIG. 3 shows the back condition after treatment; figure 4 shows the abdominal condition after treatment.

Patient 2: chen and Yi, women, 37 years old, 1 month and 30 days of 2013 for initial diagnosis, and complaining: scaling papule, erythema and itching of the whole body can be generated for more than 10 years. The current medical history: the scaly erythema, pimple and itching appear repeatedly on the whole body for 10 years, and the traditional Chinese medicine and western medicine treatment in various hospitals has not been effective, but the existing rash takes a plurality of trunks as the rash, is relatively dense and small in erythema, desquamation, large scaly rash of scalp, intolerance of cold, cold hands and feet, poor reception, stool, menses, swollen and light tongue, thin and white fur and deep pulse. And (3) diagnosis: psoriasis, dialectical: yang deficiency with external cold and damp-heat in the interior. The product obtained from example 7 was used, 2 times per day. And B, diagnosis: the skin lesions all subsided, no new eruption, pale and swollen tongue with reddish tip, white coating and greasy coating, and weak pulse.

Patient 3: for men, the age of 64 years is 64 years, the patients have no obvious inducement to the appearance of erythema scattered in drops on the whole body before telling 1 year, the patients are diagnosed as psoriasis in local hospitals, the treatment is unknown, the skin lesions recur within 2 months after being cured, the treatment effect is poor by continuing the previous method, the skin lesions gradually increase within 1 year and obviously worsen before 2 months. The symptoms at the time of clinic are as follows: the scaly erythema is thick on the back and the limbs, a large amount of scales are dry, the skin lesions on the extending sides of the upper limbs, the thighs and the buttocks are fused into hypertrophic patch, the skin lesions are dark red, the pruritus at night is obvious, the skin lesions are aversive to cold, and the skin lesions are aggravated in cold days; if the food is taken orally, bitter taste in the morning, dry stool, 1 time in 2-3 days, pale tongue with thin and white coating, and wiry pulse. And (3) Western diagnosis: psoriasis. Traditional Chinese medicine diagnosis: and (4) the psoriasis. Syndrome type: syndrome of yang deficiency with external cold and skin stasis and heat. Therapeutic method: warm yang, relieve exterior syndrome, cool blood and clear heat. The product obtained from example 7 was used, 2 times per day. And B, diagnosis: the skin damage is reduced after the medicine is taken, the skin damage is dark, the mouth is bitter, the stool is dry, the tongue is pale, the root of the coating is yellow and greasy, and the pulse is wiry. Three diagnoses: the skin lesions mostly disappear, the double hips and thighs are dark brown and pigmented, a little papule is left on the bent sides of the shanks and the forearms, the tongue is pale, the coating is yellowish and greasy, and the pulse is wiry.

Finally, it should be noted that: the above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The composition for treating psoriasis caused by external cold and internal heat is characterized by being prepared from the following raw materials in parts by weight:

2. The composition for treating psoriasis caused by internal heat in the external cold is prepared from the following raw materials in parts by mass:

5-15 parts of ephedra, 8-18 parts of divaricate saposhnikovia root, 15-45 parts of buffalo horn, 7-22 parts of radix rehmanniae, 15-45 parts of lithospermum, 7-22 parts of gardenia and 7-22 parts of raw sophora flower.

3. The composition for treating psoriasis caused by external cold and internal heat according to claim 2, wherein the composition is prepared from the following raw materials in parts by mass:

4. The composition for treating psoriasis caused by internal heat in the external cold is prepared from the following raw materials in parts by mass:

10 parts of ephedra herb, 12 parts of divaricate saposhnikovia root, 30 parts of buffalo horn, 15 parts of raw rehmannia root, 30 parts of sinkiang arnebia root, 15 parts of gardenia and 15 parts of raw sophora flower.

5. A preparation for treating psoriasis caused by external cold and internal heat, which is prepared from the traditional Chinese medicine composition for treating psoriasis caused by external cold and internal heat according to any one of claims 1 to 4.

6. A method of preparing a formulation as claimed in claim 5, for treating psoriasis caused by internal heat in external cold, comprising:

7. The method for preparing a preparation for treating psoriasis caused by internal heat in the external cold as claimed in claim 6, wherein the raw materials are mixed and then treated, comprising: mixing the above raw materials, and decocting in water to obtain decoction;

the feed-liquid ratio is 1:3-5.

8. The method for preparing a preparation for treating psoriasis caused by internal heat in external cold as claimed in claim 7, wherein the number of times of decoction is 2-3 times, and the length of decoction is 20-30 min/time.

9. The preparation method of claim 6, wherein the raw materials are mixed and then treated, and the preparation method comprises the following steps: mixing the above raw materials, extracting with water to obtain raw material extract powder, and adding solidifying agent to obtain pill;

10. The preparation method of claim 9, wherein the solidifying agent comprises honey and/or beeswax.