CN114886556A - Device for blood intraluminal treatment using ultrafast laser - Google Patents
Device for blood intraluminal treatment using ultrafast laser Download PDFInfo
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- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
- A61B18/245—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter for removing obstructions in blood vessels or calculi
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- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
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- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
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Abstract
The invention discloses a device for carrying out blood lumen internal treatment by utilizing ultrafast laser, which comprises an ultrafast laser, an optical fiber catheter, an optical fiber coupling module and an operation auxiliary structure. The ultrafast laser is used for generating and outputting ultrafast laser pulses; the optical fiber coupling module is arranged at the input end of the optical fiber catheter and is used for coupling the ultrafast laser pulse output by the ultrafast laser and transmitting the ultrafast laser pulse to the conducting optical fiber bundle of the optical fiber catheter, the conducting optical fiber bundle is used for receiving the ultrafast laser pulse output by the optical fiber coupling module and transmitting the ultrafast laser pulse to the output end of the optical fiber catheter, and the ultrafast laser pulse is output forwards from the output end of the optical fiber catheter to carry out radiation ablation on lesion in a vascular cavity; the operation auxiliary structure is used for being arranged in a cavity structure of the optical fiber catheter, guiding the optical fiber catheter to a lesion in a vascular cavity and delivering cooling liquid, contrast medium or/and medicine to the lesion in the vascular cavity. The invention can safely and efficiently realize the effects of erosion and volume reduction in the vascular cavity.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a device for carrying out blood lumen internal treatment by utilizing ultrafast laser.
Background
Thrombosis and atherosclerotic plaque are the leading causes of cardiovascular disease in humans. Thrombus is mainly composed of fibrin, platelets, white blood cells, red blood cells and the like in a human body, can affect coronary arteries and peripheral arteries and veins, and has extremely high acute ischemia lethality of organ tissues caused by the thrombus. Atherosclerotic plaques are those formed along the walls of the medium and large arteries that contain cholesterol, fatty acids, cellular waste and calcified deposits, which can cause narrowing of the lumen of the vessels, such as the medium and large arteries, and are the leading cause of coronary heart disease, stroke and peripheral arteriosclerotic disease. Therefore, prevention and treatment of thrombus and atherosclerotic plaque are important problems for reducing the mortality of people, improving the quality of life and relieving the medical burden of society.
At present, the means for removing thrombus and plaque in the vascular cavity mainly comprise two main categories of drug treatment and operation treatment, except that a few acute-phase diseases can be treated by drugs, most of thrombus and plaque still need to be removed by operations, so as to quickly reduce the load in the vascular cavity and improve the functions of organs. The modern minimally invasive surgery utilizes a minimally invasive catheter to remove thrombus and plaque through medicines or instruments, has small surgical trauma but still has certain limitations, such as long-time retention of a medicine thrombolysis catheter, bleeding risk of thrombolysis medicines, relatively low efficiency of the mechanical removal catheter on subacute thrombus or high risk of vascular wall injury rupture and the like, and limits the wide development of the current minimally invasive thrombus removal surgery.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art. Therefore, the invention aims to provide a device for carrying out endovascular treatment by utilizing ultrafast laser, which can safely and efficiently remove thrombus and plaque to realize good endovascular erosion and volume reduction effect.
The device for treating the blood supply lumen by utilizing the ultrafast laser comprises an ultrafast laser, an optical fiber catheter, an optical fiber coupling module and an operation auxiliary structure; wherein, the ultrafast laser is used for generating and outputting ultrafast laser pulses; the optical fiber coupling module is arranged at the input end of the optical fiber catheter and is used for coupling the ultrafast laser pulse output by the ultrafast laser and transmitting the ultrafast laser pulse to the conducting optical fiber bundle of the optical fiber catheter, the conducting optical fiber bundle is used for receiving the ultrafast laser pulse output by the optical fiber coupling module and transmitting the ultrafast laser pulse to the output end of the optical fiber catheter, and the ultrafast laser pulse is output forwards from the output end of the optical fiber catheter to carry out radiation ablation on lesion in a vascular cavity; the operation auxiliary structure is used for being arranged in a cavity structure of the optical fiber catheter, guiding the optical fiber catheter to a lesion in a blood vessel cavity and conveying cooling liquid, contrast medium or/and medicine to the lesion in the blood vessel cavity.
According to the device for the blood supply intraluminal treatment by using the ultrafast laser, the device has the advantages that firstly, ultrafast laser pulses are transmitted to lesion parts (such as thrombus and plaque) in a vascular lumen through the optical fiber catheter for radiation ablation, compared with the traditional medicine and operation treatment method, the device has high accuracy, basically has no thermal injury to irradiated surrounding tissues, and can realize safe and efficient ablation and volume reduction effects in the vascular lumen; secondly, the adopted ultrafast laser is convenient to integrate and develop, maintenance is almost not needed, the use cost is low, and the energy of a light beam is stable; thirdly, coupling transmission of laser energy is carried out on the ultrafast laser pulse by using the optical fiber coupling module, so that the ultrafast laser pulse can adaptively enter a conducting optical fiber bundle, the energy loss of the ultrafast laser pulse is reduced, and the ablation efficiency of the ultrafast laser pulse is improved; fourthly, the operation difficulty of an operator can be obviously reduced by the arrangement of the operation auxiliary structure, the actual ablation operation and control of the operator are facilitated, and the universal device has strong universality.
According to some embodiments of the invention, the ultrafast laser is a solid state ultrafast laser or a fiber ultrafast laser.
According to some embodiments of the invention, the fiber coupling module employs a free space coupling module or a fiber mode coupling module.
According to some embodiments of the present invention, when the fiber coupling module adopts the free space coupling module, the apparatus for performing endovascular therapy with ultrafast laser further includes a collimated beam expanding optical path, which is disposed between the ultrafast laser and the free space coupling module, and is configured to process ultrafast laser pulses output by the ultrafast laser, so that the processed ultrafast laser pulses are adaptively coupled with the free space coupling module.
According to some embodiments of the invention, the collimated expanded beam optical path includes a first optical isolator for preventing backscattered light from returning into the ultrafast laser.
According to some embodiments of the invention, the free-space coupling module is an optical element of a planar focusing array.
According to some embodiments of the invention, the free space coupling module is a micro lens array or a micro nano optical device.
According to some embodiments of the present invention, when the fiber mode coupling module is adopted by the fiber coupling module, the fiber mode coupling module includes a laser pigtail output end connected to the ultrafast laser, and a second fiber isolator, where the laser pigtail output end, the second fiber isolator, and the input end of the conductive fiber bundle are sequentially matched and welded, and the second fiber isolator is configured to prevent backward scattered light from returning into the ultrafast laser.
According to some embodiments of the invention, the conducting fiber bundle is a low-loss fiber bundle.
According to some embodiments of the invention, the low-loss fiber bundle is formed by one or more of a general step-index fiber, a photonic crystal fiber, a micro-structured fiber and a hollow fiber.
According to some embodiments of the invention, the optical fibers of the bundle of conducting optical fibers are in a rectangular arrangement or a circular arrangement at the input end and are fixed using a first rim, and the optical fibers of the bundle of conducting optical fibers are in a circular arrangement or an eccentric arrangement at the output end and are fixed using an inner rim and an outer rim and are protected using a protection window.
According to some embodiments of the invention, the apparatus for providing intraluminal treatment with ultrafast laser further comprises a laser detection module and a control module; the laser detection module is used for separating a small part of light beams from ultrafast laser pulses output by the ultrafast laser to carry out laser parameter detection and feeding back detected data to the control module; the control module is used for controlling the switch operation and the mode switching of the device for the blood supply intraluminal treatment by using the ultrafast laser and setting the laser parameters to be corrected in an automatic or manual mode according to the data fed back by the laser detection module.
According to some embodiments of the present invention, when the fiber coupling module adopts a free space coupling module, the laser detection module includes a beam splitter and a first detector; the beam splitter is used for splitting a small part of beams from ultrafast laser pulses output by the ultrafast laser; the first detector is used for detecting laser parameters of the small part of the light beams split by the beam splitter and feeding back the small part of the light beams to the control module; when the optical fiber mode coupling module of claim 8 is adopted as the optical fiber coupling module, the laser detection module includes a detection optical fiber and a second detector, one end of the detection optical fiber and the input end of the conduction optical fiber bundle are welded together in a matching manner with the output end of the laser pigtail, the other end of the detection optical fiber is connected to the second detector, and the second detector calculates the actual laser parameters in the optical path according to the ratio of the number of the optical fibers in the detection optical fiber to the sum of the number of the optical fibers in the detection optical fiber and the number of the optical fibers in the conduction optical fiber bundle and feeds back the actual laser parameters to the control module.
According to some embodiments of the invention, the control module comprises a display interface and a key interface; the display interface is used for displaying parameters; the key interface is used for setting parameters, switching a work/correction mode and switching an automatic/manual mode in a correction mode so as to control the ultrafast laser to output ultrafast laser pulses and perform parameter correction in an automatic or manual mode according to data fed back by the laser detection module.
According to some embodiments of the present invention, the "automatic" mode is that an internal circuit and a program process the data fed back by the laser detection module, and automatically corrects the wrong laser parameters; and the manual mode is to manually correct wrong laser parameters by using the key interface according to the data fed back by the laser detection module and displayed on the display interface.
According to some embodiments of the invention, a merging port is provided on the fiber optic conduit at a location proximate the output end, the merging port being in communication with the cavity structure; the operation auxiliary structure comprises a guide wire and an infusion tube, the guide wire and the infusion tube are used for entering the cavity structure from the merging interface, the guide wire is used for guiding the optical fiber catheter to a lesion part in a vascular cavity, and the infusion tube is used for conveying cooling liquid, contrast medium or/and medicine to the lesion part in the vascular cavity.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
FIG. 1 is a schematic diagram of the structure of an apparatus for delivering intraluminal treatment with ultrafast laser light according to one embodiment of the present invention.
Fig. 2 is a schematic structural view of an apparatus for supplying intraluminal treatment with ultrafast laser according to another embodiment of the present invention.
Fig. 3 is a schematic diagram of an arrangement of optical fibers at an input end of a conducting fiber bundle according to an embodiment of the present invention.
Fig. 4 is a schematic diagram of an optical fiber arrangement at an output end of a bundle of conducting optical fibers according to an embodiment of the present invention.
FIG. 5 is a schematic view of another fiber arrangement at the output end of a bundle of conducting fibers according to an embodiment of the present invention.
FIG. 6 is a cross-sectional view of a surgical assistant in a cavity structure according to an embodiment of the present invention.
FIG. 7 is a longitudinal cross-sectional view of a surgical assistant in a cavity configuration according to an embodiment of the present invention.
Fig. 8 is a schematic view of an operation interface of a control module according to an embodiment of the present invention.
Fig. 9 is a control flow block diagram of a control module according to an embodiment of the present invention.
Reference numerals:
Ultrafast laser 1
Conducting fiber bundle 201 input 2011 output 2013 first rim 2014
Optical fiber coupling module 3
Free space coupling module 301 collimation beam expanding optical path 302 optical fiber mode coupling module 303
Laser tail fiber output end 3031 and second fiber isolator 3032
Beam splitter 501 first detector 502 detects optical fiber 503 second detector 504
Vascular lumen A lesion B
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
An apparatus 1000 for supplying intraluminal treatment with ultrafast laser light according to an embodiment of the present invention will be described with reference to fig. 1 to 9.
As shown in fig. 1 to 7, the device 1000 for supplying intraluminal treatment with ultrafast laser according to the embodiment of the present invention includes an ultrafast laser 1, a fiber optic catheter 2, a fiber coupling module 3 and a surgical assistant structure 4; wherein, the ultrafast laser 1 is used for generating and outputting ultrafast laser pulses (as shown by solid arrows in fig. 1); the fiber coupling module 3 is arranged at the input end 2011 of the fiber guide tube 2, and is used for coupling the ultrafast laser pulse output by the ultrafast laser 1 and transmitting the ultrafast laser pulse to the conducting fiber bundle 201 (as shown in fig. 4 and 5) of the fiber guide tube 2, the conducting fiber bundle 201 is used for receiving the ultrafast laser pulse transmitted by the fiber coupling module 3 and transmitting the ultrafast laser pulse to the output end 2013 of the fiber guide tube 2, and the ultrafast laser pulse is output forward from the output end 2013 of the fiber guide tube 2 to perform radiation ablation on lesion B (such as thrombus or plaque) in the blood vessel cavity a (as shown in fig. 1 and 2); the surgical assistant 4 is used for being arranged in the cavity structure 202 of the fiber optic catheter 2, guiding the fiber optic catheter 2 to the lesion B in the blood vessel lumen a, and for delivering a cooling liquid, a contrast agent or/and a drug to the lesion B in the blood vessel lumen a (as shown in fig. 1 and 2).
Specifically, the ultrafast laser 1 as a high-energy light source can generate and output ultrafast laser pulses. Ultrafast laser pulse that ultrafast laser 1 output possesses picosecond, femtosecond level's pulse width and very high instantaneous peak power, can produce plasma effect and then carry out high-efficient vaporization erosion to biological tissue with biological tissue effect to satisfy the medical requirement of blood vessel A internal reduction well. For example, when the ultra-fast laser pulse has a plurality of wave bands such as medium wave infrared, near infrared, and frequency doubling and frequency tripling, the ultra-fast laser pulse can generate a plurality of effects such as plasma when acting on biological tissues, and further carry out efficient vaporization and ablation on the biological tissues.
The fiber coupling module 3 is arranged at the input end 2011 of the fiber guide tube 2 and is used for coupling the ultrafast laser pulse output by the ultrafast laser 1 and transmitting the ultrafast laser pulse to the conducting fiber bundle 201 of the fiber guide tube 2, that is, by arranging the fiber coupling module 3, the ultrafast laser pulse output by the ultrafast laser 1 can adaptively enter the conducting fiber bundle 201, the energy loss of the ultrafast laser pulse is reduced, and the ablation efficiency of the ultrafast laser pulse is improved.
The conducting optical fiber bundle 201 is used for receiving the ultrafast laser pulse transmitted by the optical fiber coupling module 3 and transmitting the ultrafast laser pulse to the output end 2013 of the optical fiber conduit 2, and the ultrafast laser pulse is output forwards from the output end 2013 of the optical fiber conduit 2 so as to perform radiation ablation on a lesion B in a vascular cavity A. Specifically, the conducting optical fiber bundle 201 mainly has the function of conducting ultrafast laser pulses, so that the ultrafast laser pulses can be directly irradiated on the lesion B in the vascular cavity A at a short distance, therefore, the optical fiber catheter 2 can be inserted into the vascular cavity A when in use, the output end 2013 of the optical fiber catheter 2 can be directly contacted with the lesion B, then the lesion B is directly irradiated by the ultrafast pulse laser output by the output end 2013 of the optical fiber catheter 2, the lesion B in the vascular cavity A is subjected to radiation ablation, the ablation efficiency is high, and the surrounding tissues are almost not damaged; carry out radiation ablation to pathological change B department in the vascular cavity A through optic fibre pipe 2 with ultrafast laser pulse, compare in traditional medicine and operation treatment method, possess high accuracy and basically not have thermal damage to the tissue around the irradiation, can realize the effect of erosion and volume reduction in the vascular cavity A of safe efficient.
The operation assisting structure 4 is used for being arranged in the cavity structure 202 of the optical fiber catheter 2 and guiding the optical fiber catheter 2 to the lesion B in the blood vessel cavity A. When the device is used, the front end of the operation auxiliary structure 4 extends into a lesion B in a blood vessel cavity A, then the optical fiber catheter 2 extends into the blood vessel cavity A along the operation auxiliary structure 4 until the output end 2013 touches the lesion B in the blood vessel cavity A, and then the lesion B is ablated by using ultrafast laser pulse without damaging other tissues in the blood vessel cavity A; that is to say, the operation auxiliary structure 4 can guide the optical fiber catheter 2 to reach the lesion B quickly, accurately and conveniently, so that the operation difficulty of the operator is reduced remarkably, the actual ablation operation and control of the operator are facilitated, and the operation auxiliary structure has strong universality.
The surgical assist structure 4 may also be used to deliver cooling fluid, contrast media or/and drugs to the lesion B within the vessel lumen a. The use of the operation aid 4 to deliver a cooling fluid (e.g. saline) to the lesion B in the vessel lumen a for eliminating thermal effects that may be generated by the ablation process; the operation auxiliary structure 4 is utilized to convey a contrast agent to the lesion B in the blood vessel cavity A so as to carry out angiography on the blood vessel, thereby being convenient for observing the condition of the lesion B or the ablation condition in the blood vessel cavity A; the operation auxiliary structure 4 is used for delivering medicines, such as medicines with the efficacy of promoting the repair of the blood vessel wall and the like, to the lesion B in the blood vessel cavity A so as to obtain better operation treatment effect.
According to the device 1000 for the intravascular treatment of blood supply by using ultrafast laser, disclosed by the embodiment of the invention, firstly, ultrafast laser pulses are transmitted to lesion B (such as thrombus and plaque) in the blood vessel cavity A through the optical fiber catheter 2 for radiation ablation, compared with the traditional medicine and operation treatment method, the device has high accuracy and basically has no thermal injury to irradiated surrounding tissues, and the safe and efficient effects of ablation and volume reduction in the blood vessel cavity A can be realized; secondly, the adopted ultrafast laser 1 is convenient to integrate and develop, almost does not need maintenance, has low use cost and stable beam energy; thirdly, the fiber coupling module 3 is used for coupling and transmitting the laser energy to the ultrafast laser pulse, so that the ultrafast laser pulse can adaptively enter the conducting fiber bundle 201, the energy loss of the ultrafast laser pulse is reduced, and the ablation efficiency of the ultrafast laser pulse is improved; fourthly, the operation auxiliary structure 4 can obviously reduce the operation difficulty of the operator, is convenient for the actual ablation operation and control of the operator, and has stronger universality.
According to some embodiments of the present invention, the ultrafast laser 1 is a solid ultrafast laser or a fiber ultrafast laser, both of which can generate ultrafast laser pulses having picosecond and femtosecond-level pulse widths and extremely high instantaneous peak power, and can react with biological tissues to generate plasma effect to efficiently vaporize and erode the biological tissues, thereby well meeting the medical requirements of volume reduction in the vascular cavity a. The solid ultrafast laser or the optical fiber ultrafast laser is convenient to integrate and develop, long in service life, almost free of maintenance, low in use cost, stable in light beam energy and more reliable in clinical application effect. Preferably, the fiber ultrafast laser 1 is a fiber femtosecond pulse laser with a wavelength of 1030-1035nm, stable output laser beam energy, compact equipment, long service life and almost no need of maintenance.
According to some embodiments of the present invention, the fiber coupling module 3 employs a free space coupling module 301 or a fiber mode coupling module 303. That is to say, both the free space coupling module 301 and the fiber mode coupling module 303 are adopted to enable the ultrafast laser pulse output by the ultrafast laser 1 to adaptively enter the conducting fiber bundle 201, so that the energy loss of the ultrafast laser pulse is reduced, and the ablation efficiency of the ultrafast laser pulse is improved. Meanwhile, the free space coupling module 301 can reduce the operation difficulty of an operator, is convenient for the actual ablation operation and control of the operator, and has strong universality. When the fiber coupling module 3 is the fiber mode coupling module 303, the fiber mode coupling module 303 performs energy transmission in a coupling mode of a fiber mode coupler, so that the whole full optical fiber of the ultrafast laser blood supply intraluminal treatment device 1000 in the embodiment of the invention is realized, the device has a compact structure, is convenient to integrate, and has low manufacturing difficulty.
According to some embodiments of the present invention, as shown in fig. 1, when the fiber coupling module 3 employs a free space coupling module 301, the apparatus 1000 for performing intralumen treatment with ultrafast laser further includes a collimated beam expanding optical path 302, where the collimated beam expanding optical path 302 is disposed between the ultrafast laser 1 and the free space coupling module 301, and is configured to process ultrafast laser pulses output by the ultrafast laser 1, so that the processed ultrafast laser pulses are adaptively coupled to the free space coupling module 301. It should be noted that, the collimation and beam expansion optical path 302 is used to make the ultrafast laser pulse beam output from the ultrafast laser 1, collimation is performed and has better parallelism, and the light field irradiated onto the free space coupling module 301 is uniform, so that after the ultrafast laser pulse output from the collimation and beam expansion optical path 302 is coupled by the free space coupling module 301, the focused light spot of the ultrafast laser pulse may be located on the focal plane of the free space coupling module 301, and the position of the focused light spot is prevented from changing. When the input end 2011 of the conducting optical fiber bundle 201 is arranged on the focal plane of the free space coupling module 301, and the end face of the optical fiber in the conducting optical fiber bundle 201 corresponds to the focusing light spot, efficient matching coupling transmission of the ultrafast laser pulse is realized; the arrangement of the collimation beam expanding light path 302 also facilitates the adjustment of the laser beam aperture of the ultrafast laser pulse, so that the aperture angle during ultrafast laser pulse coupling does not exceed the numerical aperture of the optical fiber in the conducting optical fiber bundle 201 of the optical fiber conduit 2, the laser mode field area is matched with the conducting mode field area of the optical fiber core in the conducting optical fiber bundle 201 of the optical fiber conduit 2, the mode coupling condition is met, and more efficient coupling is realized.
According to some embodiments of the present invention, the collimated expanded beam optical path 302 includes a first optical isolator, and the first optical isolator is configured to prevent backward scattered light from returning into the ultrafast laser 1, so as to protect the ultrafast laser 1, prevent the backward scattered light from damaging the ultrafast laser 1, and prolong the service life of the ultrafast laser 1.
According to some embodiments of the present invention, the free space coupling module 301 is an optical element of a planar focusing array, and it can be understood that the optical element of the planar focusing array can converge the ultrafast pulse laser on each focusing point of the optical element of the planar focusing array, and each focusing point corresponds to each fiber end face position in the conducting fiber bundle 201 of the fiber guide 2 one by one, so that the ultrafast laser pulse output by the ultrafast laser 1 can adaptively enter the conducting fiber bundle 201, thereby reducing energy loss of the ultrafast laser pulse and improving ablation efficiency of the ultrafast laser pulse.
According to some embodiments of the invention, the free space coupling module 301 is a micro lens array or a micro nano optics. The micro lens array or the micro-nano optical device can converge the ultrafast pulse laser on each focusing point, and each focusing point corresponds to each optical fiber end face position in the conducting optical fiber bundle 201 of the optical fiber conduit 2 one by one, so that the ultrafast laser pulse output by the ultrafast laser 1 can adaptively enter the conducting optical fiber bundle 201, the energy loss of the ultrafast laser pulse is reduced, and the ablation efficiency of the ultrafast laser pulse is improved. Specifically, the microlens array is equivalent to a plurality of small lenses arranged in the same plane and having the same focal length, and after a light beam formed by the ultrafast laser pulse enters the microlens array, a series of focusing light spots are formed on the focal plane of the microlens array, that is, each small lens has its own focusing light spot, and the focusing light spots correspond to the plurality of optical fibers in the conducting optical fiber bundle 201 one by one, so that the ultrafast laser pulse output by the ultrafast laser 1 is correspondingly coupled into the plurality of optical fibers in the conducting optical fiber bundle 201.
According to some embodiments of the present invention, when the fiber coupling module 3 adopts the fiber mode coupling module 303, the fiber mode coupling module 303 includes a laser pigtail output 3031 connected to the ultrafast laser 1, a second fiber isolator 3032, the laser pigtail output 3031, the second fiber isolator 3032 and the input 2011 of the conducting fiber bundle 201 are sequentially matched and welded, and the second fiber isolator 3032 is configured to prevent backward scattered light from entering the ultrafast laser 1. As shown in fig. 2, the laser pigtail output end 3031, the second fiber isolator 3032 and the input end 2011 of the conducting fiber bundle 201 are sequentially welded in a matching manner, so that the ultrafast laser pulse output by the ultrafast laser 1 can adaptively enter the conducting fiber bundle 201, the energy loss of the ultrafast laser pulse is reduced, and the ablation efficiency of the ultrafast laser pulse is improved. When the optical fiber structures of the laser tail fiber output end 3031 and the input end 2011 of the conducting optical fiber bundle 201 are the same, the laser tail fiber output end 3031 and the input end 2011 of the conducting optical fiber bundle 201 are directly welded; when the optical fiber structures of the laser tail fiber output end 3031 and the input end 2011 of the conducting optical fiber bundle 201 are different, the input end 2011 of the conducting optical fiber bundle 201 forms a structure similar to an optical fiber combiner through processes of tapering, welding and the like, and then is welded with the laser tail fiber output end 3031, so that mode matching with the laser tail fiber output end 3031 is realized, and coupling efficiency is improved. The second fiber isolator 3032 protects the ultrafast laser 1, prevents backward scattering light from damaging the ultrafast laser 1, and prolongs the service life of the ultrafast laser 1.
According to some embodiments of the present invention, the conducting fiber bundle 201 is a low-loss fiber bundle, so as to improve the conducting efficiency of the ultrafast laser pulse, reduce the loss of the ultrafast laser pulse during the transmission process, and simultaneously ensure the stability of the energy of the ultrafast laser pulse output by the ultrafast laser blood-supplying intraluminal treatment device 1000 of the present invention.
According to some embodiments of the present invention, the low-loss fiber bundle is formed by one or more of a common step-index fiber, a photonic crystal fiber, a micro-structured fiber, and a hollow fiber, and it can be understood that the common step-index fiber, the photonic crystal fiber, the micro-structured fiber, and the hollow fiber all have the characteristics of being capable of transmitting ultrafast laser pulses with low loss, and can be selected as needed in practical applications. In addition, the low-loss optical fiber bundle can also comprise a multi-mode crystal optical fiber bundle, the coupling difficulty of the multi-mode crystal optical fiber bundle is low, and the laser energy attenuation is reduced.
According to some embodiments of the present invention, the optical fibers in the conducting optical fiber bundle 201 are arranged in a rectangular form or a circular form at the input end 2011 and are fixed by the first rim 2014, so as to facilitate the coupling operation, for example, as shown in fig. 3, the optical fibers in the conducting optical fiber bundle 201 are arranged in a rectangular form of m × n, m ranges from 8 to 10, and n ranges from 9 to 10. The fibers in the bundle 201 are in a circular arrangement (as shown in fig. 4) or an off-center arrangement (as shown in fig. 5) at the output end 2013 and are secured with an inner bezel 2015 and an outer bezel 2016 and protected with a protection window 204. The inboard cavity structure 202 that is of interior frame 2015 to leave the space that sets up of operation auxiliary structure 4, the setting of protection window 204 is used for sealing the optic fibre that is located output 2013 between interior frame 2015 and outer frame 2016, and the protection optic fibre does not receive pollution, and ultrafast laser pulse can see through protection window 204 and jet out. It will be appreciated that the number of fibers at the input 2011 and at the output 2013 are equal.
Preferably, the diameter of the core of the optical fiber in the conducting optical fiber bundle 201 is 100-.
According to some embodiments of the present invention, as shown in fig. 1 and 2, the device 1000 for performing an intraluminal treatment using ultrafast laser according to embodiments of the present invention further includes a laser detection module 5 and a control module 6; the laser detection module 5 is used for separating a small part of light beams from ultrafast laser pulses output by the ultrafast laser 1 to perform laser parameter detection and feeding back detected data to the control module 6. It can be understood that the laser detection module 5 calculates the actual laser parameters of the ultrafast laser pulse according to the laser parameters of the small portion of the beam and the ratio of the small portion of the beam to the ultrafast laser pulse, and then feeds the detected data back to the control module 6, so that the control module 6 can display the data obtained by the detection and/or control the device 1000 for intraluminal treatment using ultrafast laser according to the detected data. The control module 6 is used for controlling the switch operation and mode switching, such as a working mode or a correction mode, of the device 1000 for intravascular treatment of blood supply with ultrafast laser, and setting automatic or manual correction laser parameters according to data fed back by the laser detection module 5 so as to ensure the safe and efficient operation of the laser ablation process. The automatic mode is that the feedback data is processed by an internal circuit and a program, and the wrong laser parameters of the ultrafast laser 1 are automatically corrected; the manual mode is to manually correct the erroneous laser parameters of the ultrafast laser 1 according to the feedback data displayed on the display interface 601.
According to some embodiments of the present invention, as shown in fig. 1, when the fiber coupling module 3 employs the free space coupling module 301, the laser detection module 5 includes a beam splitter 501 and a first detector 502; the beam splitter 501 is used for splitting a small part of beams from ultrafast laser pulses output by the ultrafast laser 1; for example, the beam splitter 501 may split a small portion of the beam by reflecting a portion of the ultrafast laser pulse at an angle to the first detector 502. Preferably, the splitting ratio of the beam splitter 501 may be 99/1. The first detector 502 is used for detecting laser parameters of a small part of light beams split by the beam splitter 501 and feeding back the small part of light beams to the control module 6, so that the detection of the laser parameters of the ultrafast laser pulses is realized, the ablation operation difficulty is effectively reduced, and the safety of an ablation process of lesions is improved. It will be appreciated that the first detector 502 will calculate the actual laser parameters of the ultrafast laser pulse based on the split ratio of the beam splitter 501 and feed back to the device control module 6 to provide data for automatically or manually modifying the laser parameters of the ultrafast laser 1. In particular, the first detector 502 may be an energy meter or a first optical power meter.
As shown in fig. 2, when the fiber coupling module 3 adopts the fiber mode coupling module 303, the laser detection module 5 includes a detection fiber 503 and a second detector 504, one end of the detection fiber 503 and an input end 2011 of the conducting fiber bundle 201 are welded together in a matching manner with an output end 3031 of the laser pigtail, the other end of the detection fiber 503 is connected to the second detector 504, and the second detector 504 calculates actual laser parameters in the optical path according to a ratio of the number of fibers in the detection fiber 503 to the sum of the number of fibers in the detection fiber 503 and the number of fibers in the conducting fiber bundle 201 and feeds back the actual laser parameters to the control module 6, so as to detect laser parameters of ultrafast laser pulses output by the ultrafast laser 1, thereby effectively reducing difficulty of ablation operation and improving safety of ablation process of lesions. In a specific example, 2 to 3 optical fibers in the conducting optical fiber bundle 201 may be taken out as the detection optical fibers 503 and connected to the second detector 504, and then laser parameters in the optical path are calculated according to a ratio of the number of the optical fibers in the detection optical fibers 503 to the total number of the optical fibers in the conducting optical fiber bundle 201 and fed back to the device control module 6. The second detector 504 may be a second optical power meter.
According to some embodiments of the invention, as shown in fig. 8, the control module 6 includes a display interface 601 and a key interface 602; the display interface 601 is used for displaying parameters; the key interface 602 is used for setting parameters, switching between "working/correcting" mode and "automatic/manual" mode in "correcting" mode, so as to control the ultrafast laser 1 to output ultrafast laser pulses and perform parameter correction in an automatic or manual manner according to data fed back by the laser detection module 5, thereby ensuring accurate and normal use of the ultrafast laser 1. Specifically, as shown in fig. 8, the operation interface of the control module 6 is shown, the display interface 601 may be a liquid crystal display interface, and the key interface 602 includes a number key, a "power" key, a "repetition frequency" key, an "ok" key, an "on/off" key, an "output" key, an "work/correct" key, and an "auto/manual" key, where pressing and lifting represent different functions or operation modes. After the numbers are input, the 'confirm' button is clicked to input and set the laser parameters; the 'on/off' key is pressed to represent that the control module 6 is started, and the key is lifted to represent that the control module 6 is shut down; the 'output' key is pressed to represent ultrafast laser pulse output, and the key is lifted to represent stopping laser pulse output; the 'working/correcting' key is pressed to represent that a 'correcting' mode is selected, meanwhile, an 'automatic/manual' key indicator lamp is turned on, the key is lifted to represent that a 'working' mode is selected, and meanwhile, the 'automatic/manual' key indicator lamp is turned off; the 'automatic/manual' key is pressed to represent that a 'manual' mode is selected, the key is lifted to represent that an 'automatic' mode is selected, and the control mode is simple and convenient and is convenient to operate.
When the device 1000 for endovascular treatment using ultrafast laser according to the embodiment of the present invention is specifically used, as shown in fig. 9, the control module 6 is first turned on, and the control module 6 continuously detects whether the ultrafast laser 1 is turned on, and if the ultrafast laser 1 is turned on, performs a control operation to select a "correction" or "working" mode; after the 'correction' mode is selected, an 'automatic' mode or a 'manual' mode is further selected, after the 'automatic' mode is selected, the key interface 602 is used for setting laser parameters and outputting ultrafast laser pulses, feedback data is processed through an internal circuit and a program, error laser parameters are automatically corrected, after the 'manual' mode is selected, the key interface 602 is used for setting laser parameters and outputting laser pulses, and the key interface 602 is used for correcting the error laser parameters according to the feedback data displayed on the display interface 601.
According to some embodiments of the present invention, the "automatic" mode is that the internal circuit and program process the data fed back by the laser detection module 5, and automatically corrects the wrong laser parameters; the manual mode is to manually correct the wrong laser parameters by using the key interface 602 according to the data fed back by the laser detection module 5 displayed on the display interface 601, so that an operator can correct the wrong laser parameters in different ways to meet the actual requirements, and the application range is wide.
According to some embodiments of the present invention, as shown in fig. 1 and 2, the fiber optic catheter 2 is provided with a merging port 203 at a location near the output end 2013, the merging port 203 being in communication with the cavity structure 202, such that the surgical assistant structure 4 can enter the cavity structure 202 through the merging port 203; as shown in fig. 6 and 7, the surgical assistance structure 4 includes a guide wire 401 and an infusion tube 402, the guide wire 401 and the infusion tube 402 being used to enter the cavity structure 202 from the merging port 203. The guide wire 401 is used for guiding the optical fiber catheter 2 to a lesion B in the blood vessel cavity a, and in use, the guide wire 401 is firstly inserted into the cavity structure 202 from the merging port 203, and then the output end 2013 of the optical fiber catheter 2 can move along the guide wire 401 to accurately and quickly reach the lesion. The infusion line 402 is used to deliver cooling fluid, contrast media, or/and medication to the lesion B in the lumen a of the blood vessel. For example, the infusion tube 402 is used for injecting physiological saline to the irradiation area to cool the possible thermal effect, the iodine contrast agent is infused and the condition of the lesion B in the blood vessel cavity A is observed under fluoroscopy, and the infusion tube 401 can be used for delivering medicine to meet the operation requirement and improve the operation treatment effect.
According to some embodiments of the present invention, the end surface of the output end 2013 of the optical fiber conduit 2 is in a spherical or planar shape, so that a situation that the ultrafast laser pulse is seriously scattered due to defects existing on the end surface of the output end 2013 can be avoided, energy loss of the ultrafast laser pulse is reduced, and a light emitting effect of the output end 2013 is ensured. Preferably, the end surface of the output end 2013 of the optical fiber conduit 2 is a spherical surface, so that the divergence angle of the ultrafast laser pulse output from the output end 2013 can be reduced, and the irradiated energy density can be increased.
According to some embodiments of the present invention, the repetition rate of the ultrafast laser pulses may be adjusted according to actual radiation ablation requirements.
A specific example of the present invention is given below.
In this particular example, the device 1000 for delivering intraluminal treatment with ultrafast laser comprises an ultrafast laser 1, a fiber optic catheter 2, a fiber optic coupling module 3, a surgical assistant structure 4, a laser detection module 5 and a control module 6; wherein, the ultrafast laser 1 is used for generating and outputting ultrafast laser pulses; the optical fiber coupling module 3 is arranged at an input end 2011 of the optical fiber conduit 2 and is used for coupling the ultrafast laser pulse output by the ultrafast laser 1 and transmitting the ultrafast laser pulse to the conducting optical fiber bundle 201 of the optical fiber conduit 2, the conducting optical fiber bundle 201 is used for receiving the ultrafast laser pulse transmitted by the optical fiber coupling module 3 and transmitting the ultrafast laser pulse to an output end 2013 of the optical fiber conduit 2, the ultrafast laser pulse is output forwards from the output end 2013 of the optical fiber conduit 2 to perform radiation ablation on a lesion B in a vascular cavity A, optical fibers in the conducting optical fiber bundle 201 are arranged in a rectangular mode at the input end 2011 and are fixed by adopting a first rim 2014, and optical fibers in the conducting optical fiber bundle 201 are arranged in a ring mode at the output end 2013, are fixed by adopting an inner rim 2015 and an outer rim 2016 and are protected by adopting a protection window 204. The operation auxiliary structure 4 is arranged in the cavity structure 202 of the optical fiber catheter 2, guides the optical fiber catheter 2 to a lesion B in a blood vessel cavity A, and is used for conveying cooling liquid, contrast medium or/and medicine to the lesion B in the blood vessel cavity A, and the laser detection module 5 is used for separating a small part of light beams from ultrafast laser pulses output by the ultrafast laser 1 to perform laser parameter detection and feeding detected data back to the control module 6; the control module 6 is used for controlling the switch operation and the mode switching of the device for treating in the ultrafast laser blood supply lumen A, and setting the laser parameters to be corrected in an automatic or manual mode according to the data fed back by the laser detection module 5.
The control module 6 comprises a display interface 601 and a key interface 602; the display interface 601 is used for displaying parameters; the key interface 602 is used for setting parameters, switching between "working/correcting" mode and "automatic/manual" mode in "correcting" mode, so as to control the ultrafast laser 1 to output ultrafast laser pulses and perform parameter correction in an automatic or manual manner according to data fed back by the laser detection module 5. The 'automatic' mode is that an internal circuit and a program process the data fed back by the laser detection module 5, and the wrong laser parameters are automatically corrected; the "manual" mode is to manually correct the wrong laser parameters by using the key interface 602 according to the data fed back by the laser detection module 5 displayed on the display interface 601.
A merging port 203 is arranged on the optical fiber conduit 2 at a position close to the output end 2013, and the merging port 203 is communicated with the cavity structure 202; the surgery assistance structure 4 comprises a guide wire 401 and an infusion tube 402, the guide wire 401 and the infusion tube 402 being used for entering the cavity structure 202 from the merging port 203, the guide wire 401 being used for guiding the fiber optic catheter 2 to the lesion B in the vessel lumen a, the infusion tube 402 being used for delivering cooling liquid, contrast agent or/and drugs to the lesion B in the vessel lumen a.
The steps of use of this embodiment include,
step S1: starting up the ultrafast laser 1, starting up the control module 6, selecting a 'correction' mode, setting laser parameters by using the key interface 602, outputting ultrafast laser pulses, detecting the actually output laser parameters by using the laser detection module 5, feeding back the laser parameters to the control module 6 for parameter correction, and stopping outputting ultrafast laser;
step S2: the operation auxiliary structure 4 reaches the lesion B in the blood vessel cavity A, such as thrombus and plaque, in the blood vessel of the human body in a minimally invasive intervention way;
step S3: sleeving the optical fiber catheter 2 on the operation auxiliary structure 4, extending the output end 2013 of the conducting optical fiber bundle 201 into the blood vessel cavity A along the operation auxiliary structure 4, and sending the output end to the thrombus and plaque in the blood vessel cavity A;
step S4: selecting a 'working' mode, setting parameters of the ultrafast laser 1 by using a key interface 602 of the control module 6, and outputting ultrafast laser pulses to perform irradiation ablation on thrombus and plaque in the blood vessel cavity A;
step S5: in the process of ablation, the operation auxiliary structure 4 is firstly pushed a short distance, the optical fiber conduit 2 is then gradually pushed according to the actual ablation speed, and the steps are repeated in such a way;
step S6: inputting a contrast agent through the infusion tube 402 in the operation auxiliary structure 4, observing angiography, and if ablation is difficult to perform or a blood flow path is not recovered, referring to a numerical value fed back to the display interface 601 by the laser detection module 5, performing fine adjustment on laser parameters or performing irradiation ablation for a period of time by using the key interface 602 of the control module 6; if the blood flow path is recovered, the output of the ultrafast laser is stopped, the control module 6 is shut down, the ultrafast laser 1 is shut down, the operation auxiliary structure 4 is withdrawn firstly, and the optical fiber catheter 2 is withdrawn afterwards.
The device for the intravascular treatment by utilizing the ultrafast laser has the advantages that firstly, ultrafast laser pulses are transmitted to lesion B (such as thrombus and plaque) in the blood vessel cavity A through the optical fiber catheter 2 for radiation ablation, compared with the traditional medicine and operation treatment method, the device has high accuracy and basically has no thermal injury to irradiated surrounding tissues, and the safe and efficient ablation and volume reduction effects in the blood vessel cavity A can be realized; secondly, the adopted ultrafast laser 1 is convenient to integrate and develop, almost does not need maintenance, has low use cost and stable beam energy; thirdly, the fiber coupling module 3 is used for coupling and transmitting the laser energy to the ultrafast laser pulse, so that the ultrafast laser pulse can adaptively enter the conducting fiber bundle 201, the energy loss of the ultrafast laser pulse is reduced, and the ablation efficiency of the ultrafast laser pulse is improved; fourthly, the operation auxiliary structure 4 can obviously reduce the operation difficulty of the operator, is convenient for the actual ablation operation and control of the operator, and has stronger universality. The functions and advantages of other corresponding structures of this specific embodiment are the same as those described above, and are not described herein again.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an illustrative embodiment," "an example," "a specific example," or "some examples" or the like are intended to mean that a particular feature, structure, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
Claims (16)
1. A device for carrying out blood lumen internal treatment by utilizing ultrafast laser is characterized by comprising an ultrafast laser, an optical fiber catheter, an optical fiber coupling module and an operation auxiliary structure; wherein, the ultrafast laser is used for generating and outputting ultrafast laser pulses; the optical fiber coupling module is arranged at the input end of the optical fiber catheter and is used for coupling the ultrafast laser pulse output by the ultrafast laser and transmitting the ultrafast laser pulse to the conducting optical fiber bundle of the optical fiber catheter, the conducting optical fiber bundle is used for receiving the ultrafast laser pulse output by the optical fiber coupling module and transmitting the ultrafast laser pulse to the output end of the optical fiber catheter, and the ultrafast laser pulse is output forwards from the output end of the optical fiber catheter to carry out radiation ablation on lesion in a vascular cavity; the operation auxiliary structure is used for being arranged in a cavity structure of the optical fiber catheter, guiding the optical fiber catheter to a lesion in a vascular cavity and delivering cooling liquid, contrast medium or/and medicine to the lesion in the vascular cavity.
2. The device for providing endovascular therapy with ultrafast laser according to claim 1, wherein said ultrafast laser is a solid ultrafast laser or a fiber ultrafast laser.
3. The device for intravascular treatment of blood using ultrafast laser according to claim 1, wherein the fiber coupling module is a free space coupling module or a fiber mode coupling module.
4. The device for intravascular treatment of ultrafast laser according to claim 3, wherein when the fiber coupling module is the free space coupling module, the device for intravascular treatment of ultrafast laser further comprises a collimated beam expanding optical path disposed between the ultrafast laser and the free space coupling module for processing ultrafast laser pulses output from the ultrafast laser, such that the processed ultrafast laser pulses are adaptively coupled to the free space coupling module.
5. An apparatus for providing intravascular treatment with ultrafast laser light as claimed in claim 4, wherein said collimated expanded beam light path includes a first optical isolator for preventing backscattered light from entering back into said ultrafast laser.
6. The apparatus of claim 3 wherein the free space coupling module is an optical element of a planar focusing array.
7. The device for providing intravascular treatment with ultrafast laser according to claim 6, wherein the free space coupling module is a micro lens array or a micro nano optical device.
8. The device of claim 3, wherein when the fiber mode coupling module is adopted, the fiber mode coupling module comprises a laser pigtail output end connected to the ultrafast laser, and a second fiber isolator, wherein the laser pigtail output end, the second fiber isolator and the input end of the conductive fiber bundle are sequentially matched and welded, and the second fiber isolator is used for preventing backward scattered light from returning into the ultrafast laser.
9. The device for providing intraluminal treatment with ultrafast laser light according to claim 1, wherein said conducting fiber bundle is a low loss fiber bundle.
10. The apparatus of claim 9, wherein the low loss fiber bundle is one or more of a conventional step index fiber, a photonic crystal fiber, a micro-structured fiber, and a hollow fiber.
11. The apparatus of claim 1, wherein the optical fibers of the bundle are fixed at the input end by a first frame and the optical fibers of the bundle are fixed at the output end by an inner frame and an outer frame and a protection window.
12. An apparatus for providing intravascular treatment with ultrafast laser light as set forth in claim 3, further comprising a laser detection module and a control module; the laser detection module is used for separating a small part of light beams from ultrafast laser pulses output by the ultrafast laser to carry out laser parameter detection and feeding back detected data to the control module; the control module is used for controlling the switch operation and the mode switching of the device for the blood supply intraluminal treatment by utilizing the ultrafast laser and setting the laser parameters to be corrected in an automatic or manual mode according to the data fed back by the laser detection module.
13. The apparatus for intravascular treatment of blood using ultrafast laser according to claim 12, wherein when the fiber coupling module employs a free space coupling module, the laser detecting module comprises a beam splitter and a first detector; the beam splitter is used for splitting a small part of beams from ultrafast laser pulses output by the ultrafast laser; the first detector is used for detecting laser parameters of the small part of the light beams split by the beam splitter and feeding back the small part of the light beams to the control module; when the optical fiber mode coupling module of claim 8 is adopted as the optical fiber coupling module, the laser detection module includes a detection optical fiber and a second detector, one end of the detection optical fiber and the input end of the conduction optical fiber bundle are welded together in a matching manner with the output end of the laser pigtail, the other end of the detection optical fiber is connected to the second detector, and the second detector calculates the actual laser parameters in the optical path according to the ratio of the number of the optical fibers in the detection optical fiber to the sum of the number of the optical fibers in the detection optical fiber and the number of the optical fibers in the conduction optical fiber bundle and feeds back the actual laser parameters to the control module.
14. The apparatus for providing intravascular treatment with ultrafast laser according to claim 12, wherein said control module comprises a display interface and a key interface; the display interface is used for displaying parameters; the key interface is used for setting parameters, switching a work/correction mode and switching an automatic/manual mode in a correction mode so as to control the ultrafast laser to output ultrafast laser pulses and perform parameter correction in an automatic or manual mode according to data fed back by the laser detection module.
15. The apparatus of claim 14, wherein the "automatic" mode is an automatic correction of erroneous laser parameters by processing the data fed back from the laser detection module with internal circuitry and programming; and the manual mode is to manually correct wrong laser parameters by using the key interface according to the data fed back by the laser detection module and displayed on the display interface.
16. The apparatus of claim 1, wherein a merging port is provided on the fiber optic catheter at a location near the output end, the merging port communicating with the cavity structure; the operation auxiliary structure comprises a guide wire and an infusion tube, the guide wire and the infusion tube are used for entering the cavity structure from the merging interface, the guide wire is used for guiding the optical fiber catheter to a lesion part in a vascular cavity, and the infusion tube is used for conveying cooling liquid, contrast medium or/and medicine to the lesion part in the vascular cavity.
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| CN102512206A (en) * | 2011-12-13 | 2012-06-27 | 苏州生物医学工程技术研究所 | Intravenous ultrasound-based ultrasonic diagnosis and photoacoustic therapy device and therapeutic method thereof |
| CN105636540A (en) * | 2013-10-15 | 2016-06-01 | 尼普洛株式会社 | ablation system and ablation device |
| WO2021046643A1 (en) * | 2019-09-11 | 2021-03-18 | North Star Specialists Inc. | Catheter, sheath or dilator for heart valve decalcification treatment and method of use thereof |
| CN113057732A (en) * | 2021-03-25 | 2021-07-02 | 哈尔滨医科大学 | Laser ablation catheter |
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2022
- 2022-03-30 CN CN202210334439.2A patent/CN114886556A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101247027A (en) * | 2007-02-15 | 2008-08-20 | 昂纳明达数字显示技术（深圳）有限公司 | Red laser module for laser display |
| CN101897619A (en) * | 2010-07-12 | 2010-12-01 | 中国科学院长春光学精密机械与物理研究所 | Long-wave high-power semiconductor laser comprehensive therapeutic instrument |
| CN102512206A (en) * | 2011-12-13 | 2012-06-27 | 苏州生物医学工程技术研究所 | Intravenous ultrasound-based ultrasonic diagnosis and photoacoustic therapy device and therapeutic method thereof |
| CN105636540A (en) * | 2013-10-15 | 2016-06-01 | 尼普洛株式会社 | ablation system and ablation device |
| WO2021046643A1 (en) * | 2019-09-11 | 2021-03-18 | North Star Specialists Inc. | Catheter, sheath or dilator for heart valve decalcification treatment and method of use thereof |
| CN113057732A (en) * | 2021-03-25 | 2021-07-02 | 哈尔滨医科大学 | Laser ablation catheter |
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