CN114794091A - Low-temperature disinfection powder and preparation method and application thereof - Google Patents
Low-temperature disinfection powder and preparation method and application thereof Download PDFInfo
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- CN114794091A CN114794091A CN202210253243.0A CN202210253243A CN114794091A CN 114794091 A CN114794091 A CN 114794091A CN 202210253243 A CN202210253243 A CN 202210253243A CN 114794091 A CN114794091 A CN 114794091A
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- 239000000843 powder Substances 0.000 title claims abstract description 115
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 97
- 238000002360 preparation method Methods 0.000 title abstract description 8
- 239000000645 desinfectant Substances 0.000 claims abstract description 188
- 239000003381 stabilizer Substances 0.000 claims abstract description 125
- 239000000080 wetting agent Substances 0.000 claims abstract description 125
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 122
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 68
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 58
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 46
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 45
- 238000002156 mixing Methods 0.000 claims description 42
- -1 polyoxyethylene lauryl ether Polymers 0.000 claims description 34
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 claims description 34
- 239000011780 sodium chloride Substances 0.000 claims description 34
- 229960004543 anhydrous citric acid Drugs 0.000 claims description 29
- 150000003839 salts Chemical class 0.000 claims description 29
- MSFGZHUJTJBYFA-UHFFFAOYSA-M sodium dichloroisocyanurate Chemical compound [Na+].ClN1C(=O)[N-]C(=O)N(Cl)C1=O MSFGZHUJTJBYFA-UHFFFAOYSA-M 0.000 claims description 28
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 27
- OKBMCNHOEMXPTM-UHFFFAOYSA-M potassium peroxymonosulfate Chemical compound [K+].OOS([O-])(=O)=O OKBMCNHOEMXPTM-UHFFFAOYSA-M 0.000 claims description 27
- 230000001954 sterilising effect Effects 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 10
- 239000001509 sodium citrate Substances 0.000 claims description 10
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 10
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 9
- 235000006408 oxalic acid Nutrition 0.000 claims description 9
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 9
- 238000007710 freezing Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 3
- 230000002147 killing effect Effects 0.000 abstract description 19
- 241000588724 Escherichia coli Species 0.000 abstract description 6
- 208000002979 Influenza in Birds Diseases 0.000 abstract description 6
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 6
- 206010064097 avian influenza Diseases 0.000 abstract description 6
- 230000000052 comparative effect Effects 0.000 description 36
- 239000002131 composite material Substances 0.000 description 25
- 230000000694 effects Effects 0.000 description 21
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 239000001301 oxygen Substances 0.000 description 9
- 229910052760 oxygen Inorganic materials 0.000 description 9
- 244000052769 pathogen Species 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 239000012425 OXONE® Substances 0.000 description 6
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid group Chemical group S(N)(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 6
- 230000000249 desinfective effect Effects 0.000 description 5
- 239000008233 hard water Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 230000002528 anti-freeze Effects 0.000 description 4
- 230000008021 deposition Effects 0.000 description 4
- 230000008014 freezing Effects 0.000 description 4
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 4
- 230000001590 oxidative effect Effects 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 239000007798 antifreeze agent Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000007922 dissolution test Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 125000004430 oxygen atom Chemical group O* 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- HJKYXKSLRZKNSI-UHFFFAOYSA-I pentapotassium;hydrogen sulfate;oxido sulfate;sulfuric acid Chemical compound [K+].[K+].[K+].[K+].[K+].OS([O-])(=O)=O.[O-]S([O-])(=O)=O.OS(=O)(=O)O[O-].OS(=O)(=O)O[O-] HJKYXKSLRZKNSI-UHFFFAOYSA-I 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000006701 autoxidation reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a low-temperature disinfection powder and a preparation method and application thereof, wherein the low-temperature disinfection powder comprises the following components in parts by mass: 80% -90% of an antifreezing agent; 0.1 to 3 percent of disinfectant; 8 to 15 percent of stabilizer; 1% -5% of a regulator; 0.1 to 1 percent of wetting agent. The low-temperature disinfectant disclosed by the invention has the advantages that the killing log value of the low-temperature disinfectant on staphylococcus aureus reaches more than 3.00, the killing log value of the low-temperature disinfectant on escherichia coli reaches more than 3.03, and the killing rate on avian influenza H5N1 virus reaches more than 99.9% when the low-temperature disinfectant is applied for 5 min.
Description
Technical Field
The invention relates to a disinfectant, in particular to low-temperature disinfection powder and a preparation method and application thereof.
Background
The low-temperature disinfectant is the latest generation of antifreeze and cold-resistant disinfectant at present, and solves the difficult problems of winter disinfection and epidemic prevention. The low-temperature disinfectant has the advantages of simple and convenient use, high efficiency, broad spectrum and strong sterilizing capability.
After the conventional liquid disinfectant is used in a low-temperature environment, the disinfectant applied to the surface of an object is crystallized and frozen due to low temperature, so that the effective components are rapidly degraded, and the disinfection effect is reduced.
Disclosure of Invention
In view of this, the main object of the present invention is to provide a low temperature disinfection powder, a preparation method and an application thereof, which are intended to solve the technical problem that the disinfection powder applied to the surface of an object in a low temperature environment will not be crystallized and frozen, and will not be limited by the requirements of winter disinfection and epidemic prevention and environmental temperature, so as to save time and labor.
The purpose of the invention and the technical problem to be solved are realized by adopting the following technical scheme. The invention provides low-temperature disinfection powder, which comprises the following components in percentage by mass:
80% -90% of an antifreezing agent; 0.1 to 3 percent of disinfectant; 8 to 15 percent of stabilizer; 1% -5% of a regulator; 0.1 to 1 percent of wetting agent.
The object and the technical problem to be solved by the present invention can be further achieved by the following technical measures.
Preferably, the low-temperature disinfection powder comprises the following components in parts by weight:
80% -83% of an antifreezing agent; 1.1 to 2.2 percent of disinfectant; 11.6 to 13 percent of stabilizer; 1% -2% of a regulator; 0.4 to 0.6 percent of wetting agent.
Preferably, the low-temperature sterilization powder comprises the following components in percentage by mass: 65% -82% of industrial anhydrous calcium chloride; 18 to 35 percent of industrial anhydrous magnesium chloride.
Preferably, the low-temperature sterilization powder comprises the following components in percentage by mass: 71% -75% of industrial anhydrous calcium chloride; 25 to 29 percent of industrial anhydrous magnesium chloride.
Preferably, the low-temperature sterilizing powder is one of potassium hydrogen peroxymonosulfate complex salt and sodium dichloroisocyanurate powder.
Preferably, the low-temperature sterilizing powder described above, wherein the stabilizer is at least one selected from the group consisting of industrial sodium chloride and industrial sodium citrate.
Preferably, the low-temperature sterilizing powder described above, wherein the conditioning agent is at least one selected from the group consisting of anhydrous citric acid, sulfamic acid and oxalic acid.
Preferably, the low-temperature sterilizing powder is one in which the wetting agent is at least one selected from polyoxyethylene lauryl ether and sodium dodecylbenzene sulfonate.
The object of the present invention and the technical problems solved thereby can be further achieved by the following technical measures. The invention provides a preparation method of low-temperature disinfection powder, which comprises the following steps:
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
The object of the present invention and the technical problems solved thereby can also be achieved by the following technical measures. The invention provides a low-temperature disinfection method, which comprises the following steps:
mixing the low-temperature disinfectant with water according to a ratio, fully dissolving, and then spraying the mixture on the surface of an article to be disinfected, or soaking the article to be disinfected into the mixture, or wiping the surface of the article to be disinfected; the ratio of the low-temperature disinfectant to the water is (50-55) g: 100 ml.
Compared with the prior art, the low-temperature disinfection powder, the preparation method and the application thereof have the following beneficial effects:
the present invention interferes with the synthesis of DNA and RNA by a pathogen, such as a bacterium or virus, by adding a disinfectant, which in turn causes its rapid death.
The invention can obviously change the acidity of the solution in the aspect of pH detection and measurement by adding the acidity regulator, the low-temperature disinfectant is in a faintly acid pH value less than 4 before being dissolved by water, and the low-temperature disinfectant is gradually oxidized into neutrality after being dissolved by the water, so that the product is more environment-friendly.
By adding the antifreezing agent, the liquid dissolved after being applied to the surface of an object in a low-temperature environment can not be crystallized and frozen.
The invention can slow down the descending speed of the effective components of the low-temperature disinfectant and improve the stability of the product by adding the stabilizer.
The invention can improve the adhesiveness and deposition of the low-temperature disinfectant on the surface of the medicine receiving agent, improve the release speed and the expansion area of the effective components under the condition of moisture and improve the sterilization and disinfection effects by adding the wetting agent.
The low-temperature disinfection powder has the killing logarithm value of more than 3.00 to staphylococcus aureus, the killing logarithm value of more than 3.03 to escherichia coli and the killing rate of more than 99.9 percent to avian influenza H5N1 virus when the low-temperature disinfection powder is acted for 5 min.
The foregoing is a summary of the present invention, and in order to provide a clear understanding of the technical means of the present invention and to be implemented in accordance with the present specification, the following is a detailed description of the preferred embodiments of the present invention.
Detailed Description
To further illustrate the technical means and effects of the present invention adopted to achieve the predetermined objects, the following detailed description will be given to a low-temperature sterilizing powder, a preparation method thereof, and specific embodiments, structures, characteristics and effects thereof according to the present invention. In the following description, different "one embodiment" or "an embodiment" refers to not necessarily the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
Unless otherwise specified, the following materials, reagents and the like are commercially available products well known to those skilled in the art; unless otherwise specified, all methods are well known in the art. Unless defined otherwise, technical or scientific terms used herein shall have the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs. The following procedures or conditions, which are not specifically mentioned, may be performed according to the procedures or conditions of the conventional experimental procedures described in the literature in the art.
According to some embodiments of the present invention, there is provided a low-temperature sterilizing powder, which can be applied in a low-temperature environment of-40 ℃ at the minimum, and comprises, by mass:
80% -90% of an antifreezing agent; 0.1 to 3 percent of disinfectant; 8 to 15 percent of stabilizer; 1% -5% of a regulator; 0.1 to 1 percent of wetting agent.
In the technical scheme, the mass percent of the antifreezing agent can be 80% -83%, 84% -87% or 88% -90%, preferably 80% -83%, and if the mass percent of the antifreezing agent is less than 80%, crystallization and freezing can occur in a low-temperature environment of-40 ℃; above 90%, the quantity of other components is insufficient, and the overall effect of the low-temperature disinfectant is affected.
The mass percent of the disinfectant can be 0.1-1%, 1.1-2% or 2.1-3%, preferably 1.1-2%, and if the mass percent of the disinfectant is less than 0.1%, the bacteria killing effect of the low-temperature disinfectant can be influenced; above 3%, the quantity of other components is insufficient, and the overall effect of the low-temperature disinfectant is affected.
The mass percent of the stabilizer can be 10% -11.5%, 11.6% -13% or 13.1% -15%, preferably 11.6% -13%, if the mass percent of the stabilizer is less than 8%, the main bactericidal component in the low-temperature disinfectant can be accelerated to run off; above 15%, the amount of other components is insufficient, and the overall effect of the low-temperature disinfectant is affected.
The mass percent of the regulator can be 1% -2%, 2% -4% or 4% -5%, preferably 1% -2%, and if the mass percent of the regulator is less than 1%, the quantity of other components is insufficient, so that the overall effect of the low-temperature disinfectant is influenced; if the pH value is higher than 5%, the pH value of the dissolved liquid is in an alkaline state, so that the environment and the surface of the liquid object which is dissolved by contacting the low-temperature disinfectant are damaged.
The wetting agent can be 0.1-0.3%, 0.4-0.6% or 0.7-1% by mass. Preferably 0.4-0.6%, if the mass percent of the wetting agent is less than 0.1%, the adhesion and deposition amount, release speed and expansion area of the liquid on the surface of a disinfection object after the low-temperature disinfectant is dissolved can be influenced, so that the sterilization and disinfection effects are weakened; above 1%, the quantity of other components is insufficient, and the overall effect of the low-temperature disinfectant is affected.
In some embodiments, the antifreeze agent may be composed of, in mass percent: 65% -82% of industrial anhydrous calcium chloride; 18 to 35 percent of industrial anhydrous magnesium chloride.
Further, the mass percentage of the industrial grade anhydrous calcium chloride can be 65% -70%, 71% -75%, 76% -82%, preferably 71% -75%, and if the mass percentage of the industrial grade anhydrous calcium chloride is less than 65%, crystallization and freezing can occur in a low-temperature environment of-40 ℃; above 82% there will be insufficient amounts of other components, which will affect the overall effect of the low temperature disinfectant.
The mass percentage of the industrial anhydrous magnesium chloride can be 30-35%, 25-29% or 18-24%, preferably 25-29%, and if the mass percentage of the industrial anhydrous magnesium chloride is less than 18%, the instant temperature rise effect of the anhydrous magnesium chloride cannot achieve the best effect of dissolving the low-temperature disinfectant; above 35% there will be insufficient amounts of other components, affecting the overall effectiveness of the low temperature disinfectant.
In some embodiments, the disinfectant is at least one of sodium dichloroisocyanurate and potassium peroxymonosulfate complex salt, the main function of the disinfectant is a main disinfecting and sterilizing component in the low-temperature disinfectant, the particle size range is required to be 60 meshes-100 meshes, and the preferred particle size is 90 meshes, so that the water dissolving effect and the mixing uniformity of the low-temperature disinfectant are optimal.
In some embodiments, the stabilizer is selected from at least one of technical-grade sodium chloride and technical-grade sodium citrate, and the main function of the stabilizer is to slow down the falling speed of the effective components of the low-temperature disinfectant and improve the product stability.
In some embodiments, the conditioning agent is selected from at least one of anhydrous citric acid, sulfamic acid, and oxalic acid, which primarily functions to adjust the pH of the low temperature disinfectant.
In some embodiments, the wetting agent is selected from at least one of polyoxyethylene lauryl ether and sodium dodecyl benzene sulfonate, and the main functions of the wetting agent are to improve the adhesion and deposition of the disinfectant on the surface of a disinfection object, improve the release speed and the spreading area of the disinfectant under the condition of moisture, and improve the sterilization and disinfection effects.
In the technical scheme, the low-temperature disinfectant is kept in a liquid state after being dissolved in a low-temperature environment at the lowest temperature of-40 ℃ by adding anhydrous calcium chloride and anhydrous magnesium chloride; adding at least one of potassium hydrogen peroxymonosulfate composite salt and sodium dichloroisocyanurate powder as a main disinfecting and sterilizing component in the low-temperature disinfectant, dissolving the potassium hydrogen peroxymonosulfate composite salt with water, initiating an auto-oxidation reaction system, releasing active oxygen, and actively oxidizing a target object; meanwhile, potassium hydrogen peroxymonosulfate composite salt continuously generates hypochlorous acid and nascent oxygen through chain reaction (ozone is more active than oxygen in chemical property, when the temperature is higher, the ozone is decomposed, each ozone molecule can generate an oxygen molecule and an oxygen atom O3 ═ O2+ O, the generated oxygen atom is called nascent oxygen which is very active, has very strong oxidizing capability, oxidizes germs and is quick without odor), oxidizes and chlorinates pathogens, interferes with the synthesis of DNA and RNA of the pathogens, leads the protein of the pathogens to be coagulated and denatured, further interferes with the activity of an enzyme system of the pathogens, influences the metabolism of the pathogens, increases the permeability of cell membranes, causes the loss of enzymes and nutrient substances, dissolves and ruptures the pathogens, and further kills bacteria and viruses. Or adding sodium dichloroisocyanurate, dissolving in water, initiating an autoxidation reaction system, releasing active oxygen, and actively oxidizing the target substance. Meanwhile, after being dissolved, the sodium dichloroisocyanurate is decomposed into hypochlorous acid which releases active chlorine and slowly releases active oxygen, and the hypochlorous acid can denature the mycoprotein and change the membrane permeability, so that the physiological and biochemical functions of an enzyme system, DNA synthesis and other functions can not normally run, and pathogenic bacteria can rapidly die; at least one of industrial sodium chloride and industrial sodium citrate is added to slow down the falling speed of at least one effective component of potassium hydrogen peroxymonosulfate composite salt and sodium dichloroisocyanurate powder in the low-temperature disinfectant, improve the stability of the product and ensure a longer effective period; at least one of anhydrous citric acid, sulfamic acid and oxalic acid is added to keep the pH value of the low-temperature disinfectant in a weakly acidic state, and the pH value is gradually oxidized into neutral by the dissolution of water, so that the low-temperature disinfectant is more environment-friendly and cannot cause damage to the environment and the surface of a medicine; at least one of lauryl polyoxyethylene ether and sodium dodecyl benzene sulfonate is added to improve the adhesiveness and the deposition amount of at least one effective component of potassium peroxymonosulfate composite salt and sodium dichloroisocyanurate powder in the liquid after the low-temperature disinfectant is dissolved on the surface of a disinfection object, improve the release speed and the expansion area of the low-temperature disinfectant under the condition of moisture, and improve the sterilization and disinfection effects.
According to some embodiments of the present invention, there is provided a method for preparing the low temperature sterilizing powder, comprising the steps of:
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
According to some embodiments of the present invention, there is provided a method of low temperature sterilization, comprising the steps of:
the disinfectant is used immediately after being dissolved sufficiently according to the use ratio (low-temperature disinfectant: hard water (50-55) g: 100mL), and various hidden parts are paid special attention. The use modes comprise the following three modes:
1. spraying and disinfecting: the low-temperature disinfectant can be used in cooperation with disinfection equipment, about 15 square meters to 20 square meters can be sprayed every 1kg of dissolved liquid, and the low-temperature disinfectant can be ensured to cover a disinfection object fully.
2. Soaking and disinfecting: directly soaking in low temperature disinfectant for 10-15 min.
3. Wiping and disinfecting: ensuring that the low-temperature disinfectant covers the disinfection object in a sufficient amount, and the disinfection effect is 10-15 min.
The present invention will be further described with reference to the following examples, which should not be construed as limiting the scope of the invention, but rather as providing those skilled in the art with the necessary understanding that certain insubstantial modifications and variations of the invention can be made without departing from the spirit and scope of the invention as defined above.
Example 1: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 82% of an antifreezing agent; 0.5% of disinfectant; 13% of a stabilizer; 3.5% of a regulator; 1% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 73% of industrial-grade anhydrous calcium chloride; 27% of industrial grade anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium citrate;
the regulator is sulfamic acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 2: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 85% of an antifreezing agent; 1% of disinfectant; 12% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 82% of industrial-grade anhydrous calcium chloride; 18% of industrial grade anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt, and the granularity is 90 meshes.
The stabilizer is industrial-grade sodium chloride;
the regulator is oxalic acid;
the wetting agent is sodium dodecyl benzene sulfonate;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 3: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 83% of an antifreezing agent; 2% of disinfectant; 13% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 4: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 80% of an antifreezing agent; 0.5% of disinfectant; 15% of a stabilizer; 4.4% of a regulator; 0.1% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 5: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 87% of an antifreezing agent; 3% of disinfectant; 8% of a stabilizer; 1% of a regulator; 1% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 6: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 82% of an antifreezing agent; 0.5% of disinfectant; 13% of a stabilizer; 3.5% of a regulator; 1% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 82% of industrial-grade anhydrous calcium chloride; 18% of industrial grade anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium citrate;
the regulator is sulfamic acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 7: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 82% of an antifreezing agent; 0.5% of disinfectant; 13% of a stabilizer; 3.5% of a regulator; 1% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium citrate;
the regulator is sulfamic acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 8: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 85% of an antifreezing agent; 1% of disinfectant; 12% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 73% of industrial-grade anhydrous calcium chloride; 27% of industrial grade anhydrous magnesium chloride;
the disinfectant is potassium peroxymonosulfate composite salt with the granularity of 90 meshes.
The stabilizer is industrial-grade sodium chloride;
the regulator is oxalic acid;
the wetting agent is sodium dodecyl benzene sulfonate;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 9: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 85% of an antifreezing agent; 1% of disinfectant; 12% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is potassium peroxymonosulfate composite salt with the granularity of 90 meshes.
The stabilizer is industrial-grade sodium chloride;
the regulator is oxalic acid;
the wetting agent is sodium dodecyl benzene sulfonate;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 10: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 83% of an antifreezing agent; 2% of disinfectant; 13% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 73% of industrial-grade anhydrous calcium chloride; 27% of industrial grade anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 11: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 83% of an antifreezing agent; 2% of disinfectant; 13% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 82% of industrial-grade anhydrous calcium chloride; 18% of industrial grade anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 12: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 83% of an antifreezing agent; 2% of disinfectant; 13% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 65% of industrial anhydrous calcium chloride; 35% of industrial anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 13: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 84.5 percent of antifreeze; 2.5 percent of disinfectant; 8% of a stabilizer; 4% of a regulator; 1% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Comparative example 1: the comparative example provides a powder comprising, by mass percent: 40% of a stabilizer; 20% of a regulator; 40% of a wetting agent;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
and uniformly mixing the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the powder.
Comparative example 2: the comparative example provides a powder comprising, by mass percent: 75% of an antifreezing agent; 0.1% of disinfectant; 13% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
uniformly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the powder.
Comparative example 3: the comparative example provides a powder comprising, by mass percent: 95% of an antifreezing agent; 0.2 percent of disinfectant; 13% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
uniformly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the powder.
Comparative example 4: the comparative example provides a powder comprising, by mass percent: 18% of an antifreezing agent; 0.3 percent of disinfectant; 35% of a stabilizer; 11.7 percent of regulator; 35% of a wetting agent;
the antifreezing agent consists of industrial anhydrous magnesium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
uniformly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the powder.
Comparative example 5: the comparative example provides a powder comprising, by mass percent: 82% of an antifreezing agent; 0.4% of disinfectant; 13% of a stabilizer; 4.1% of a regulator; 0.5% of wetting agent;
the antifreezing agent consists of industrial anhydrous calcium chloride;
the disinfectant is potassium hydrogen peroxymonosulfate composite salt with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
uniformly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the powder.
Example 14: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 82% of an antifreezing agent; 0.5% of disinfectant; 13% of a stabilizer; 3.5% of a regulator; 1% of a wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 73% of industrial-grade anhydrous calcium chloride; 27% of industrial grade anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium citrate;
the regulator is sulfamic acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 15: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 85% of an antifreezing agent; 1% of disinfectant; 12% of a stabilizer; 1.5 percent of regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 82% of industrial-grade anhydrous calcium chloride; 18% of industrial grade anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes.
The stabilizer is industrial-grade sodium chloride;
the regulator is oxalic acid;
the wetting agent is sodium dodecyl benzene sulfonate;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 16: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 83% of an antifreezing agent; 2% of a disinfectant; 13% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 17: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 80% of an antifreezing agent; 0.5% of disinfectant; 15% of a stabilizer; 4.4% of a regulator; 0.1% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 18: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 87% of an antifreezing agent; 3% of disinfectant; 8% of a stabilizing agent; 1% of a regulator; 1% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 19: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 82% of an antifreezing agent; 0.5% of disinfectant; 13% of a stabilizer; 3.5% of a regulator; 1% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 82% of industrial-grade anhydrous calcium chloride; 18% of industrial grade anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium citrate;
the regulator is sulfamic acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 20: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 82% of an antifreezing agent; 0.5% of disinfectant; 13% of a stabilizer; 3.5% of a regulator; 1% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium citrate;
the regulator is sulfamic acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 21: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 85% of an antifreezing agent; 1% of disinfectant; 12% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 73% of industrial-grade anhydrous calcium chloride; 27% of industrial grade anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes.
The stabilizer is industrial-grade sodium chloride;
the regulator is oxalic acid;
the wetting agent is sodium dodecyl benzene sulfonate;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 22: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 85% of an antifreezing agent; 1% of disinfectant; 12% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 23: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 83% of an antifreezing agent; 2% of disinfectant; 13% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 73% of industrial-grade anhydrous calcium chloride; 27% of industrial grade anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 24: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 83% of an antifreezing agent; 2% of disinfectant; 13% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 82% of industrial-grade anhydrous calcium chloride; 18% of industrial grade anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 25: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 83% of an antifreezing agent; 2% of disinfectant; 13% of a stabilizer; 1.5% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 65% of industrial anhydrous calcium chloride; 35% of industrial anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Example 26: the embodiment provides a low-temperature disinfection powder, which comprises the following components in percentage by mass: 84.5 percent of antifreeze; 2.5 percent of disinfectant; 8% of a stabilizer; 4% of a regulator; 1% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
Comparative example 6: the comparative example provides a powder comprising, by mass percent: 40% of a stabilizer; 20% of a regulator; 40% of a wetting agent;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
and uniformly mixing the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the powder.
Comparative example 7: the comparative example provides a powder comprising, by mass percent: 75% of an antifreezing agent; 0.1% of disinfectant; 18% of a stabilizer; 3.5 percent of regulator; 3.4% of a wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
uniformly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the powder.
Comparative example 8: the comparative example provides a powder comprising, by mass percent: 95% of an antifreezing agent; 0.2 percent of disinfectant; 3% of a stabilizing agent; 1.3% of a regulator; 0.5% of wetting agent;
the antifreezing agent comprises the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
uniformly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the powder.
Comparative example 9: the comparative example provides a powder comprising, by mass percent: 18% of an antifreezing agent; 0.3 percent of disinfectant; 35% of a stabilizer; 11.7 percent of regulator; 35% of a wetting agent;
the antifreezing agent consists of industrial anhydrous magnesium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
uniformly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the powder.
Comparative example 10: the comparative example provides a powder comprising, by mass percent: 82% of an antifreezing agent; 0.4% of disinfectant; 13% of a stabilizer; 4.1% of a regulator; 0.5% of wetting agent;
the antifreezing agent consists of industrial anhydrous calcium chloride;
the disinfectant is sodium dichloroisocyanurate powder with the granularity of 90 meshes;
the stabilizer is industrial-grade sodium chloride;
the regulator is anhydrous citric acid;
the wetting agent is polyoxyethylene lauryl ether;
uniformly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the powder.
The main compositions and proportions of the low-temperature sterilizing powders of examples 1 to 26 and the powders of comparative examples 1 to 10 are summarized in tables 1 and 2 below.
TABLE 1
TABLE 2
| Antifreezing agent | Disinfectant | Stabilizer | Conditioning agents | Wetting agent | |
| Example 14 | 82 | 0.5 | 13 | 3.5 | 1 |
| Example 15 | 85 | 1 | 12 | 1.5 | 0.5 |
| Example 16 | 83 | 2 | 13 | 1.5 | 0.5 |
| Example 17 | 80 | 0.5 | 15 | 4.4 | 0.1 |
| Example 18 | 87 | 3 | 8 | 1 | 1 |
| Example 19 | 82 | 0.5 | 13 | 3.5 | 1 |
| Example 20 | 82 | 0.5 | 13 | 3.5 | 1 |
| Example 21 | 85 | 1 | 12 | 1.5 | 0.5 |
| Example 22 | 85 | 1 | 12 | 1.5 | 0.5 |
| Example 23 | 83 | 2 | 13 | 1.5 | 0.5 |
| Example 24 | 83 | 2 | 13 | 1.5 | 0.5 |
| Example 25 | 83 | 2 | 13 | 1.5 | 0.5 |
| Example 26 | 84.5 | 2.5 | 8 | 4 | 1 |
| Comparative example 6 | 0 | 0 | 40 | 20 | 40 |
| Comparative example 7 | 75 | 0.1 | 18 | 3.5 | 3.4 |
| Comparative example 8 | 95 | 0.2 | 3 | 1.3 | 0.5 |
| Comparative example 9 | 18 | 0.3 | 35 | 11.7 | 35 |
| Comparative example 10 | 82 | 0.4 | 13 | 4.1 | 0.5 |
The antifreezing agents in the embodiments 1, 8, 10, 14, 21 and 23 comprise the following components in percentage by mass: 73% of industrial-grade anhydrous calcium chloride; 27% of industrial grade anhydrous magnesium chloride; the antifreeze of the embodiments 2, 6, 11, 15, 19 and 24 comprises the following components in percentage by mass: 82% of industrial-grade anhydrous calcium chloride; 18% of industrial grade anhydrous magnesium chloride; the antifreezing agents of examples 3, 4, 5, 7, 9, 13, 16, 17, 18, 20, 22 and 26 and comparative examples 2, 3, 7 and 8 consist of the following components in percentage by mass: 75% of industrial-grade anhydrous calcium chloride; 25% of industrial anhydrous magnesium chloride; the antifreezing agents of examples 12 and 25 consist of the following components in percentage by mass: 65% of industrial anhydrous calcium chloride; 35 percent of industrial grade anhydrous magnesium chloride. Comparative examples 4, 9 the antifreeze agent consisted of technical grade anhydrous magnesium chloride; comparative examples 5, 10 the antifreeze agent consisted of technical grade anhydrous calcium chloride; the disinfectant described in examples 1-13 and comparative examples 2-5 was potassium hydrogen peroxymonosulfate complex salt; examples 14-26 and comparative examples 7-10 the disinfectant was sodium dichloroisocyanurate powder.
Low-temperature freezing test: according to the using proportion (low-temperature disinfectant: hard water is 50 g: 100mL), the mixture is placed at the low temperature of minus 40 ℃ for observation and recording, and the mixture is kept in a liquid state after being placed for 8 hours without precipitation or crystallization.
Water dissolution test: the water dissolution test was carried out at the use ratio (low-temperature disinfectant: hard water 50 g: 100mL), and the test result was complete dissolution.
The low-temperature disinfectants prepared in examples 1 to 26 and the disinfectants obtained in comparative examples 1 to 10 are prepared into aqueous solutions by using water (the low-temperature disinfectants are hard water, 50g and 100mL), a sterilization test method for staphylococcus aureus and escherichia coli is adopted to carry out a sterilization test in the 2002 edition of disinfection technical specifications at the low temperature of-40 ℃, and the sterilization log values are calculated and are more than or equal to 3.00 according to the specification of the 2002 edition of disinfection technical specifications; the low-temperature disinfectant powders prepared in examples 1 to 26 and the powders obtained in comparative examples 1 to 10 were prepared into aqueous solutions with water according to the low-temperature disinfectant powder/powder (hard water: 50 g: 100mL), and avian influenza H5N1 virus was subjected to a killing test by the Klein-Defors suspension killing test method under a low-temperature environment of-20 ℃, and the killing rate was calculated, and when the disinfection effect was expressed by the killing rate according to the domestic disinfectant test, the virus killing rate of the low-temperature disinfectant powder was 99.9%, and it was judged that the disinfection was acceptable, and the results were shown in tables 3 and 4.
TABLE 3 kill rates for examples 1-13 and comparative examples 1-3
TABLE 4 kill rates for examples 14-26 and comparative examples 4-6
As can be seen from the test data in tables 3 and 4, the low-temperature disinfection powder prepared by the invention has good killing effect on staphylococcus aureus and escherichia coli, and has good killing rate on avian influenza H5N1 virus. Wherein, the low-temperature disinfection powder of the embodiments 1 to 26 has the killing logarithm value of more than 3.00 to staphylococcus aureus in 5min, the killing logarithm value of more than 3.03 to escherichia coli, and the killing rate of more than 99.9 percent to avian influenza H5N1 virus, which are all higher than the comparative examples 1 to 10.
The embodiment taking the potassium monopersulfate composite salt as the disinfectant has higher killing log value on staphylococcus aureus and escherichia coli and higher avian influenza H5N1 virus killing rate than the embodiment taking sodium dichloroisocyanurate powder as the disinfectant. The difference is that the potassium monopersulfate composite salt is dissolved by water to generate hypochlorous acid and active oxygen and can also generate nascent oxygen, the nascent oxygen is very active and has very strong oxidizing capability, and bacteria can be oxidized quickly without leaving odor. Further, the best effect of example 3 was found from the analysis of the whole effect of the water-dissolved state and the low-temperature freezing test.
In the description of the present invention, numerous specific details are set forth. It is understood, however, that embodiments of the invention may be practiced without these specific details. In some embodiments, well-known methods, structures and techniques have not been shown in detail in order not to obscure an understanding of this description.
It should be noted that, in the above embodiments, the various features described in the above embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, the present invention does not separately describe various possible combinations.
In addition, any combination of the various embodiments of the present invention is also possible, and the same should be considered as the disclosure of the present invention as long as it does not depart from the spirit of the present invention.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, and any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are still within the scope of the technical solution of the present invention.
Claims (10)
1. The low-temperature disinfection powder is characterized by comprising the following components in parts by weight:
80% -90% of an antifreezing agent; 0.1 to 3 percent of disinfectant; 8 to 15 percent of stabilizer; 1% -5% of a regulator; 0.1 to 1 percent of wetting agent.
2. The low-temperature disinfectant powder according to claim 1, comprising, in parts by mass:
80% -83% of an antifreezing agent; 1.1% -2.2% of disinfectant; 11.6 to 13 percent of stabilizing agent; 1% -2% of a regulator; 0.4 to 0.6 percent of wetting agent.
3. The low-temperature sterilizing powder according to claim 1, wherein the anti-freezing agent consists of the following components in percentage by mass: 65% -82% of industrial anhydrous calcium chloride; 18 to 35 percent of industrial anhydrous magnesium chloride.
4. The low-temperature sterilizing powder according to claim 3, wherein the anti-freezing agent consists of the following components in percentage by mass: 71% -75% of industrial anhydrous calcium chloride; 25 to 29 percent of industrial anhydrous magnesium chloride.
5. The low-temperature disinfectant powder according to any of claims 1 to 4, wherein said disinfectant is at least one of potassium hydrogen peroxymonosulfate complex salt and sodium dichloroisocyanurate powder.
6. The low-temperature disinfectant powder according to any of claims 1 to 4, wherein said stabilizer is at least one selected from the group consisting of industrial sodium chloride and industrial sodium citrate.
7. A low-temperature disinfectant powder according to any of claims 1 to 4, wherein said regulator is at least one selected from the group consisting of anhydrous citric acid, sulfamic acid and oxalic acid.
8. The low-temperature disinfectant powder according to any of claims 1 to 4, wherein said wetting agent is at least one selected from the group consisting of polyoxyethylene lauryl ether and sodium dodecylbenzenesulfonate.
9. A method of preparing a low temperature disinfectant powder according to any of claims 1 to 8, comprising the steps of:
evenly mixing the antifreezing agent, the disinfectant, the stabilizer, the regulator and the wetting agent according to the formula amount to obtain the low-temperature disinfection powder.
10. A method of cryogenic disinfection comprising the steps of:
mixing the low-temperature disinfectant as claimed in any one of claims 1 to 8 with water in proportion, and after fully dissolving, spraying the mixture onto the surface of an article to be disinfected, or soaking the article to be disinfected therein, or wiping the surface of the article to be disinfected; the ratio of the low-temperature disinfectant to the water is (50-55) g: 100 ml.
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