[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CN114767719B - A pharmaceutical composition for preventing and treating rickets, and its preparation method - Google Patents

A pharmaceutical composition for preventing and treating rickets, and its preparation method Download PDF

Info

Publication number
CN114767719B
CN114767719B CN202210625483.9A CN202210625483A CN114767719B CN 114767719 B CN114767719 B CN 114767719B CN 202210625483 A CN202210625483 A CN 202210625483A CN 114767719 B CN114767719 B CN 114767719B
Authority
CN
China
Prior art keywords
vitamin
calcium carbonate
pharmaceutical composition
bacillus coagulans
gelatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202210625483.9A
Other languages
Chinese (zh)
Other versions
CN114767719A (en
Inventor
王永宏
王朝辉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Langdi Pharmaceutical Co ltd
Original Assignee
Beijing Langdi Pharmaceutical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Langdi Pharmaceutical Co ltd filed Critical Beijing Langdi Pharmaceutical Co ltd
Publication of CN114767719A publication Critical patent/CN114767719A/en
Application granted granted Critical
Publication of CN114767719B publication Critical patent/CN114767719B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to a medicinal composition for preventing and treating rickets, which consists of a medicinal active ingredient and a pharmaceutically acceptable carrier, wherein the medicinal active ingredient consists of calcium carbonate, vitamin D3, vitamin K2, bacillus coagulans and amino acid, and the content of calcium in the medicinal active ingredient is as follows in terms of calcium element: vitamin D3: vitamin K2: bacillus coagulans: the weight ratio of amino acid is 250:0.0025:0.02-0.04:15-50:80-130, the amino acid is selected from any one or the combination of glutamic acid, glutamine, lysine hydrochloride and arginine, and the particle size of the calcium carbonate is less than or equal to 20um. The invention obviously improves the treatment effect for preventing and treating diseases such as rickets and the like, and obviously improves the stability and the quality uniformity of the preparation.

Description

A pharmaceutical composition for preventing and treating rickets, and its preparation method
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a medicinal composition for preventing and treating rickets, and a preparation method and application thereof.
Background
Rickets are also called vitamin D deficiency rickets, calcium and phosphorus metabolic disorder caused by vitamin D deficiency in infants, children and adolescents, mature bone is not fully calcified due to vitamin D deficiency, and mature bone comprises long metaphyseal cartilage plates and bone tissues are not fully calcified, so that systemic chronic nutritional diseases characterized by skeletal lesions are caused, and are manifested as low-calcium convulsion, growth retardation, cachexia, easy irritation, easy respiratory tract infection in infancy and the like. The high risk group is infants within 2 years old, and can be prevented by taking sufficient vitamin D. The prevalence rate of northern rickets is higher than that of southern rickets, the prevalence rate of severe rickets is reduced year by year, but the prevalence rate of mild and moderate rickets is still high.
Calcium carbonate D 3 The tablet is prepared from calcium carbonate and vitamin D 3 The compound preparation is clinically used for calcium supplement of pregnant and lactating women, climacteric women, old people and children. Calcium is an essential element for maintaining normal function of the human nervous system, skeletal muscle system, cell membrane and capillary permeability. Vitamin D 3 The composition can promote the absorption of calcium and phosphorus in human intestinal tracts and the formation of bone, promote the calcification of human skeleton and the growth and development of the skeleton, protect teeth, is beneficial to the growth and development of placenta and fetuses of pregnant women, effectively prevent abortion, premature birth, slow development of fetuses and the like, promote acid-base balance in human serum, reduce electrolyte disorder, improve immunity and resistance, prevent the loss of amino acid in kidneys, reduce the incidence rate of cancers and the like, and is clinically used for preventing and treating osteoporosis, rickets, osteomalacia, tetany disease of infants, rickets with decayed teeth and the like. But has the disadvantages of low absorption rate of calcium and adverse reactions such as constipation and calculus.
Children, especially infants, have unhealthy development of liver and kidney functions, central nervous systems and endocrine systems, are greatly different from adults in the aspects of physiology, pathology, immunity and the like, have obvious difference in pharmacokinetics and pharmacodynamics with adults, and have the characteristics of poor drug tolerance, high incidence rate of adverse drug reactions and the like. The calcium preparation for children is mainly prepared by the way of divided dosage of adult preparation or suspension prepared by pharmacist. The method causes defects of damage to the structure of the preparation, cross contamination during preparation, poor stability, poor distribution uniformity, interaction between a solvent and a medicament, unstable bioavailability, inaccurate dosage and the like, and thus adverse medication events occur. Therefore, the development of calcium-containing pharmaceutical compositions with diversified dosage and high bioavailability is urgently needed to meet clinical requirements.
Disclosure of Invention
The invention aims to provide a medicinal composition for preventing and treating rickets, which consists of a medicinal active ingredient and a pharmaceutically acceptable carrier, wherein the medicinal active ingredient consists of calcium carbonate, vitamin D3, vitamin K2, bacillus coagulans and amino acid, and the content of calcium in the medicinal active ingredient is as follows in terms of calcium element: vitamin D3: vitamin K2: bacillus coagulans: the weight ratio of amino acid is 250:0.0025:0.02-0.04:15-50:80-130, the amino acid is selected from any one or combination of glutamic acid, glutamine, lysine hydrochloride and arginine, and the particle size of the calcium carbonate is less than or equal to 20um.
In a preferred embodiment of the present invention, the composition optionally comprises zinc gluconate.
In the preferred technical scheme of the invention, the pharmaceutical active ingredients in the composition consist of calcium carbonate, vitamin D3, vitamin K2, bacillus coagulans, amino acid and zinc gluconate, and the pharmaceutical active ingredients comprise the following calcium elements in percentage by calcium element: vitamin D3: vitamin K2: bacillus coagulans: amino acid (b): the weight ratio of the zinc gluconate is 250:0.0025:0.02-0.04:15-50:80-130:15-50, the amino acid is selected from any one or the combination of glutamic acid, glutamine, lysine hydrochloride and arginine, and the particle size of the calcium carbonate is less than or equal to 15um.
In the preferred technical scheme of the invention, the particle size of the calcium carbonate in the composition is less than or equal to 15um, preferably less than or equal to 10um.
In the preferred technical scheme of the invention, the viable count of the bacillus coagulans is more than or equal to 5 multiplied by 10 7 CFU/g, preferably ≥ 1X 10 8 CFU/g。
In a preferred technical scheme of the invention, the pharmaceutically acceptable carrier is any one or a combination of gelatin, mannitol, sorbitol, xylitol, carrageenan, pectin, agar, guar gum, arabic gum, konjac gum, xanthan gum, sodium alginate, microcrystalline cellulose, starch, dextrin, povidone, starch slurry, sodium hydroxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, hydroxypropyl methyl cellulose, polyvinylpyrrolidone, sodium stearyl fumarate, a sweetening agent, essence and a pigment.
In a preferred technical scheme of the invention, the essence is selected from any one of lemon essence, apple essence, strawberry essence, mint essence and orange essence or a combination thereof.
In a preferred technical scheme of the invention, the sweetener is selected from any one of aspartame, glucose, sucrose, sodium cyclamate, lactose, fructose, acesulfame potassium and stevioside or a combination thereof.
In a preferred technical scheme of the invention, the pigment is selected from any one of lemon yellow, carmine, erythrosine, beet red, amaranth, indigo, curcumin, carotene, sunset yellow, composite black and fluorescent fruit green or a combination thereof.
In a preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition: vitamin D3: vitamin K2: bacillus coagulans: glutamic acid: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.2:180:1250:5500:2000:1500:100:18.
In a preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition: vitamin D3: vitamin K2: bacillus coagulans: glutamine (b): gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.3:200:1250:5500:2000:1500:100:18.
In a preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition: vitamin D3: vitamin K2: bacillus coagulans: lysine hydrochloride: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.4:300:1000:5500:2000:1500:100:18.
In the preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition is as follows: vitamin D3: vitamin K2: bacillus coagulans: arginine: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.4:300:1000:5500:2000:1500:100:18.
In the preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition is as follows: vitamin D3: vitamin K2: bacillus coagulans: zinc gluconate: glutamic acid: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.2:180:300:1250:5500:2000:1500:100:18.
In a preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition: vitamin D3: vitamin K2: bacillus coagulans: zinc gluconate: glutamine (b): gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.3:200:280:1250:5500:2000:1500:100:18.
In a preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition: vitamin D3: vitamin K2: bacillus coagulans: zinc gluconate: lysine hydrochloride: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.4:300:260:1000:5500:2000:1500:100:18.
In the preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition is as follows: vitamin D3: vitamin K2: bacillus coagulans: zinc gluconate: arginine: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.4:300:350:1000:5500:2000:1500:100:18.
The pharmaceutical composition of the invention is prepared according to the conventional preparation method in the field.
Another object of the present invention is to provide a method for preparing a pharmaceutical composition for preventing and treating rickets, wherein the pharmaceutical composition comprises a pharmaceutically active ingredient and a pharmaceutically acceptable carrier, wherein the pharmaceutically active ingredient comprises calcium carbonate, vitamin D3, vitamin K2, bacillus coagulans and amino acid, and the content of calcium in the pharmaceutical active ingredient is as follows: vitamin D3: vitamin K2: bacillus coagulans: the weight ratio of the amino acid is 250:0.0025:0.02-0.04:15-50:80-130, the amino acid is selected from any one or combination of glutamic acid, glutamine, lysine hydrochloride and arginine, the particle size of the calcium carbonate is less than or equal to 20um, and the method comprises the following steps:
(1) Weighing required amounts of vitamin D3 and vitamin K2, stirring, dissolving in 95% ethanol solution, and spraying the prepared vitamin complex ethanol solution to calcium carbonate to obtain calcium carbonate containing vitamin complex;
(2) Weighing required amount of gelatin, stirring, swelling in required amount of water, stirring, heating to obtain gelatin solution, and keeping the temperature for use;
(3) Weighing the required amount of bacillus coagulans, amino acid and other pharmaceutically acceptable carriers except gelatin, stirring, uniformly mixing with calcium carbonate particles containing vitamin complex, stirring, placing the prepared mixture into a gelatin solution, uniformly mixing, pouring into a mold, and drying under reduced pressure to obtain the calcium carbonate calcium coagulant.
In a preferred embodiment of the present invention, the composition optionally comprises zinc gluconate.
In the preferred technical scheme of the invention, the pharmaceutical active ingredients in the composition consist of calcium carbonate, vitamin D3, vitamin K2, bacillus coagulans, amino acid and zinc gluconate, and the pharmaceutical active ingredients comprise the following calcium elements in percentage by calcium element: vitamin D3: vitamin K2: bacillus coagulans: amino acids: the weight ratio of the zinc gluconate to the zinc gluconate is 250:0.0025:0.02-0.04:15-50:80-130:15-50, the amino acid is selected from any one or the combination of glutamic acid, glutamine, lysine hydrochloride and arginine, and the particle size of the calcium carbonate is less than or equal to 15um.
In a preferred embodiment of the present invention, the preparation method of the composition comprises the following steps:
(1) Weighing required amounts of vitamin D3 and vitamin K2, stirring, dissolving in 95% ethanol solution, and spraying the prepared ethanol solution of vitamin complex to calcium carbonate to obtain calcium carbonate containing vitamin complex;
(2) Weighing required amount of gelatin, stirring, swelling in required amount of water, stirring, heating to obtain gelatin solution, and keeping the temperature for use;
(3) Weighing the required amount of bacillus coagulans, zinc gluconate, amino acid and other pharmaceutically acceptable carriers except gelatin, stirring, uniformly mixing with calcium carbonate particles containing multivitamins, stirring, placing the prepared mixture into a gelatin solution, uniformly mixing, pouring into a mold, and drying under reduced pressure to obtain the calcium carbonate calcium coagulant.
In the preferred technical scheme of the invention, the particle size of the calcium carbonate in the composition is less than or equal to 15um, preferably less than or equal to 10um.
In the preferred technical scheme of the invention, the viable count of the bacillus coagulans is more than or equal to 5 multiplied by 10 7 CFU/g, preferably ≥ 1X 10 8 CFU/g。
In a preferred technical scheme of the invention, the pharmaceutically acceptable carrier is any one or a combination of gelatin, mannitol, sorbitol, xylitol, carrageenan, pectin, agar, guar gum, arabic gum, konjac gum, xanthan gum, sodium alginate, microcrystalline cellulose, starch, dextrin, povidone, starch slurry, sodium hydroxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, hydroxypropyl methyl cellulose, polyvinylpyrrolidone, sodium stearyl fumarate, a sweetening agent, essence and a pigment.
In a preferred technical scheme of the invention, the essence is any one or combination of lemon essence, apple essence, strawberry essence, mint essence and orange essence.
In a preferred technical scheme of the invention, the sweetener is selected from any one of aspartame, glucose, sucrose, sodium cyclamate, lactose, fructose, acesulfame potassium and stevioside or a combination thereof.
In a preferred technical scheme of the invention, the pigment is selected from any one of lemon yellow, carmine, erythrosine, beet red, amaranth, indigo, curcumin, carotene, sunset yellow, composite black and fluorescent fruit green or a combination thereof.
In a preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition: vitamin D3: vitamin K2: bacillus coagulans: glutamic acid: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.2:180:1250:5500:2000:1500:100:18.
In a preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition: vitamin D3: vitamin K2: bacillus coagulans: glutamine (b): gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.3:200:1250:5500:2000:1500:100:18.
In a preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition: vitamin D3: vitamin K2: bacillus coagulans: lysine hydrochloride: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.4:300:1000:5500:2000:1500:100:18.
In a preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition: vitamin D3: vitamin K2: bacillus coagulans: arginine: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.4:300:1000:5500:2000:1500:100:18.
In a preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition: vitamin D3: vitamin K2: bacillus coagulans: zinc gluconate: glutamic acid: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.2:180:300:1250:5500:2000:1500:100:18.
In a preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition: vitamin D3: vitamin K2: bacillus coagulans: zinc gluconate: glutamine (b): gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.3:200:280:1250:5500:2000:1500:100:18.
In a preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition: vitamin D3: vitamin K2: bacillus coagulans: zinc gluconate: lysine hydrochloride: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.4:300:260:1000:5500:2000:1500:100:18.
In a preferred technical scheme of the invention, the calcium carbonate in the pharmaceutical composition: vitamin D3: vitamin K2: bacillus coagulans: zinc gluconate: arginine: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.4:300:350:1000:5500:2000:1500:100:18.
In a preferred embodiment of the present invention, the stirring condition is 100rpm to 1000rpm, preferably 200rpm to 800rpm, and more preferably 300rpm to 600rpm.
In the preferable technical scheme of the invention, the heating temperature is not lower than 45 ℃, preferably not lower than 50 ℃, and more preferably not lower than 60 ℃.
In the preferred technical scheme of the invention, the drying temperature is less than or equal to 60 ℃, preferably less than or equal to 50 ℃, and more preferably less than or equal to 45 ℃.
The invention also aims to provide application of the pharmaceutical composition in preparing a medicament for preventing and treating any one of osteoporosis, rickets and children growth and development disorder or complications thereof.
Another object of the present invention is to provide the use of the pharmaceutical composition of the present invention for the preparation of a calcium-supplemented or calcium-zinc-supplemented preparation.
In a preferred technical scheme, the pharmaceutical composition is used for supplementing calcium or calcium and zinc for the old, children, pregnant women and other people needing calcium supplement.
Unless otherwise indicated, when the present invention relates to percentages between liquids, said percentages are volume/volume percentages; the invention relates to the percentage between liquid and solid, said percentage being volume/weight percentage; the invention relates to the percentages between solid and liquid, said percentages being weight/volume percentages; the balance weight/weight percent.
Compared with the prior art, the invention has the following beneficial effects:
1. hair brushThe components and the mixture ratio in the pharmaceutical composition are screened scientifically, and the pharmaceutical composition comprises calcium carbonate (the particle size is less than or equal to 20 mu m) and vitamin D 3 Vitamin K 2 Zinc gluconate, amino acid, bacillus coagulans, and vitamin D 3 Vitamin K 2 Spraying to calcium carbonate, remarkably improving the stability and quality uniformity of the preparation, and promoting the body to treat calcium, zinc and vitamin D by synergistically utilizing bacillus coagulans and amino acid 3 Vitamin K 2 The absorption and utilization of the composition can improve intestinal flora of patients and inhibit intestinal helicobacter pylori, effectively and durably increase bone density, relieve bone pain, improve bone microstructure, protect bone health, promote bone formation and growth and development, protect teeth and prevent tooth decay, is beneficial to oral health, remarkably improves the treatment effect of the composition for preventing and treating rickets, osteoporosis, children growth and development disorder and other diseases, remarkably improves mouthfeel and gastrointestinal function and flatulence, constipation, calculus and other side reactions, and remarkably improves the safety and effectiveness of the pharmaceutical composition.
2. The preparation method has the advantages of simple and convenient operation, better cost, suitability for industrial production and the like.
Drawings
FIG. 1 Effect of the groups tested in test example 1 on the body weight of the rats, "+" indicates comparison with the blank control group, P < 0.05 and ". DELTA" indicates comparison with the positive control group, P < 0.05.
FIG. 2 Effect of the test groups on the bone density of rats tested in test example 1, ". X" indicates P < 0.05 compared with the placebo control group, and "Δ" indicates P < 0.05 compared with the positive control group.
FIG. 3 the effect of the test groups in test example 1 on bone calcium in the test rats, "+" indicates P < 0.05 compared with the blank control group and ". DELTA" indicates P < 0.05 compared with the positive control group.
FIG. 4 shows the effect of the test groups in test example 1 on the bone weight of the rats tested, "+" indicates comparison with the blank control group, P < 0.05, ". DELTA" indicates comparison with the positive control group, P < 0.05.
Detailed Description
The present invention will be specifically described with reference to examples. The embodiments of the present invention are only for illustrating the technical solutions of the present invention, and do not limit the essence of the present invention.
In the specific embodiment, the bacillus coagulans is commercially available, and the number of viable bacteria is not less than 1000 hundred million cfu/g.
Example 1Preparation of the pharmaceutical composition of the invention
The pharmaceutical composition comprises the following components in percentage by weight:
Figure BDA0003677130310000111
the preparation of the pharmaceutical composition of the invention comprises the following steps:
(1) Weighing required amounts of vitamin D3 and vitamin K2, stirring (300 rpm), dissolving in 95% ethanol solution, and spraying the prepared ethanol solution of vitamin complex to calcium carbonate to obtain calcium carbonate containing vitamin complex;
(2) Weighing required amount of gelatin, stirring (500 rpm), placing in required amount of water, swelling for 40min, preparing gelatin solution at 55 deg.C and 600rpm, and keeping the temperature for use;
(3) Weighing required amounts of bacillus coagulans, glutamic acid, xylitol, mannitol, strawberry essence and aspartame, stirring (600 rpm), uniformly mixing with calcium carbonate particles containing vitamin complex, stirring (600 rpm), placing the prepared mixture into a gelatin solution, uniformly mixing, pouring a mold, and drying under reduced pressure (55 ℃), thus obtaining the product.
Example 2Preparation of the pharmaceutical composition of the invention
The pharmaceutical composition of the invention comprises the following components in percentage by weight:
Figure BDA0003677130310000121
the preparation of the pharmaceutical composition of the invention comprises the following steps:
(1) Weighing required amounts of vitamin D3 and vitamin K2, stirring (250 rpm), dissolving in 95% ethanol solution, and spraying the obtained ethanol solution of vitamin complex to calcium carbonate to obtain calcium carbonate containing vitamin complex;
(2) Weighing required amount of gelatin, stirring (600 rpm), placing in required amount of water, swelling for 40min, preparing gelatin solution at 50 deg.C and 600rpm, and keeping the temperature for use;
(3) Weighing required amounts of bacillus coagulans, glutamine, xylitol, mannitol, lemon essence and aspartame, stirring (600 rpm), uniformly mixing with calcium carbonate particles containing compound vitamins, stirring (600 rpm), placing the prepared mixture into a gelatin solution, uniformly mixing, pouring a mold, and drying under reduced pressure (50 ℃), thus obtaining the product.
Example 3Preparation of the pharmaceutical composition of the invention
The pharmaceutical composition comprises the following components in percentage by weight:
Figure BDA0003677130310000131
Figure BDA0003677130310000141
the preparation of the pharmaceutical composition of the invention comprises the following steps:
(1) Weighing required amounts of vitamin D3 and vitamin K2, stirring (300 rpm), dissolving in 95% ethanol solution, and spraying the prepared ethanol solution of vitamin complex to calcium carbonate to obtain calcium carbonate containing vitamin complex;
(2) Weighing required amount of gelatin, stirring (500 rpm), placing in required amount of water, swelling for 40min, preparing gelatin solution at 55 deg.C and 600rpm, and keeping the temperature for use;
(3) Weighing required amounts of bacillus coagulans, lysine hydrochloride, xylitol, mannitol, apple essence and aspartame, stirring (600 rpm), uniformly mixing with calcium carbonate particles containing vitamin complex, stirring (600 rpm), placing the prepared mixture into a gelatin solution, uniformly mixing, pouring a mold, and drying under reduced pressure (53 ℃), thus obtaining the product.
Example 4Preparation of the pharmaceutical composition of the invention
The pharmaceutical composition of the invention comprises the following components in percentage by weight:
Figure BDA0003677130310000142
Figure BDA0003677130310000151
the preparation of the pharmaceutical composition of the invention comprises the following steps:
(1) Weighing required amounts of vitamin D3 and vitamin K2, stirring (300 rpm), dissolving in 95% ethanol solution, and spraying the prepared ethanol solution of vitamin complex to calcium carbonate to obtain calcium carbonate containing vitamin complex;
(2) Weighing required amount of gelatin, stirring (600 rpm), placing in required amount of water, swelling for 40min, preparing gelatin solution at 50 deg.C and 600rpm, and keeping the temperature for use;
(3) Weighing the required amount of bacillus coagulans, arginine, xylitol, mannitol, mint essence and aspartame, stirring (600 rpm), uniformly mixing with calcium carbonate particles containing compound vitamins, stirring (600 rpm), placing the prepared mixture into a gelatin solution, uniformly mixing, pouring into a mold, and drying under reduced pressure (50 ℃), thus obtaining the product.
Example 5Preparation of the pharmaceutical composition of the invention
The pharmaceutical composition of the invention comprises the following components in percentage by weight:
Figure BDA0003677130310000152
Figure BDA0003677130310000161
the preparation of the pharmaceutical composition of the invention comprises the following steps:
(1) Weighing required amounts of vitamin D3 and vitamin K2, stirring (300 rpm), dissolving in 95% ethanol solution, and spraying the prepared ethanol solution of vitamin complex to calcium carbonate to obtain calcium carbonate containing vitamin complex;
(2) Weighing required amount of gelatin, stirring (500 rpm), placing in required amount of water, swelling for 40min, preparing gelatin solution at 55 deg.C and 600rpm, and keeping the temperature for use;
(3) Weighing required amounts of bacillus coagulans, zinc gluconate, glutamic acid, xylitol, mannitol, strawberry essence and aspartame, stirring (600 rpm), uniformly mixing with calcium carbonate particles containing multivitamins, stirring (600 rpm), placing the prepared mixture into a gelatin solution, uniformly mixing, pouring a mold, and drying under reduced pressure (55 ℃), thus obtaining the product.
Example 6Preparation of the pharmaceutical composition of the invention
The pharmaceutical composition of the invention comprises the following components in percentage by weight:
Figure BDA0003677130310000171
the preparation of the pharmaceutical composition of the invention comprises the following steps:
(1) Weighing required amounts of vitamin D3 and vitamin K2, stirring (250 rpm), dissolving in 95% ethanol solution, and spraying the obtained ethanol solution of vitamin complex to calcium carbonate to obtain calcium carbonate containing vitamin complex;
(2) Weighing required amount of gelatin, stirring (600 rpm), placing in required amount of water, swelling for 40min, preparing gelatin solution at 55 deg.C and 600rpm, and keeping the temperature for use;
(3) Weighing required amounts of bacillus coagulans, glutamine, zinc gluconate, xylitol, mannitol, lemon essence and aspartame, stirring (600 rpm), uniformly mixing with calcium carbonate particles containing multivitamins, stirring (600 rpm), placing the prepared mixture into a gelatin solution, uniformly mixing, pouring a mold, and drying under reduced pressure (50 ℃), thus obtaining the product.
Example 7Preparation of the pharmaceutical composition of the invention
The pharmaceutical composition of the invention comprises the following components in percentage by weight:
Figure BDA0003677130310000181
the preparation of the pharmaceutical composition of the invention comprises the following steps:
(1) Weighing required amounts of vitamin D3 and vitamin K2, stirring (300 rpm), dissolving in 95% ethanol solution, and spraying the prepared ethanol solution of vitamin complex to calcium carbonate to obtain calcium carbonate containing vitamin complex;
(2) Weighing required amount of gelatin, stirring (500 rpm), placing in required amount of water, swelling for 40min, preparing gelatin solution at 55 deg.C and 600rpm, and keeping the temperature for use;
(3) Weighing required amounts of bacillus coagulans, lysine hydrochloride, zinc gluconate, xylitol, mannitol, apple essence and aspartame, stirring (600 rpm), uniformly mixing with calcium carbonate particles containing multivitamins, stirring (600 rpm), placing the prepared mixture into a gelatin solution, uniformly mixing, pouring into a mold, and drying under reduced pressure (58 ℃), thus obtaining the product.
Example 8Preparation of the pharmaceutical composition of the invention
The pharmaceutical composition of the invention comprises the following components in percentage by weight:
Figure BDA0003677130310000191
the preparation of the pharmaceutical composition of the invention comprises the following steps:
(1) Weighing required amounts of vitamin D3 and vitamin K2, stirring (300 rpm), dissolving in 95% ethanol solution, and spraying the prepared ethanol solution of vitamin complex to calcium carbonate to obtain calcium carbonate containing vitamin complex;
(2) Weighing required amount of gelatin, stirring (600 rpm), placing in required amount of water, swelling for 40min, preparing gelatin solution at 55 deg.C and 600rpm, and keeping the temperature for use;
(3) Weighing the required amount of bacillus coagulans, zinc gluconate, arginine, xylitol, mannitol, mint essence and aspartame, stirring (600 rpm), uniformly mixing with calcium carbonate particles containing multivitamins, stirring (600 rpm), placing the prepared mixture into a gelatin solution, uniformly mixing, pouring into a mold, and drying under reduced pressure (50 ℃), thus obtaining the product.
Test example 1The influence of the pharmaceutical composition on the bone mineral density and the bone weight of the rat to be tested
SPF grade female weaning SD rats were selected at 50. During the test, the test animals freely ingest and drink deionized water at room temperature of 20-24 ℃ and relative humidity of 55-68%. After one week of adaptive feeding, the rats were randomly divided into five groups, a blank control group (gavage pure water), a positive control group (calcium carbonate D3 particles produced by gavage Beijing, shadongtong, langdi pharmaceutical Co., ltd., in a dosage of 240mg/kg.bw in terms of calcium), a group I (the pharmaceutical composition of gavage example 3 in a dosage of 240mg/kg.bw in terms of calcium), a group II (the pharmaceutical composition of gavage example 5 in a dosage of 240mg/kg.bw in terms of calcium), a group III (the pharmaceutical composition of gavage example 7 in a dosage of 240mg/kg.bw in terms of calcium), and 10 rats each group. The test animals were gavaged 10mL/kg.bw daily, once daily. Weigh the body weight weekly. After continuous gavage for 12 weeks, the animals were sacrificed under anesthesia, the femurs on both sides of the test animals were removed, they were placed in an oven at 105 ℃ to dry to a constant weight, and the right femurs were weighed. And detecting the calcium content of the right femur by adopting an atomic absorption spectrophotometer method. And detecting the bone density of the left femur by adopting a full-automatic high-resolution X-ray machine. The results are shown in FIGS. 1-4.
The above description of the embodiments of the present invention is not intended to limit the present invention, and those skilled in the art may make various changes and modifications without departing from the spirit of the present invention, which should fall within the scope of the appended claims.

Claims (31)

1. A pharmaceutical composition for preventing and treating rickets, which consists of a pharmaceutical active ingredient and a pharmaceutically acceptable carrier, wherein the pharmaceutical active ingredient consists of calcium carbonate, vitamin D3, vitamin K2, bacillus coagulans and amino acid, and the content of calcium in the pharmaceutical active ingredient is as follows in terms of calcium element: vitamin D3: vitamin K2: bacillus coagulans: the weight ratio of the amino acid is 250:0.0025:0.02-0.04:15-50:80-130, wherein the amino acid is selected from any one or combination of glutamic acid, glutamine, lysine hydrochloride and arginine, the particle size of calcium carbonate is less than or equal to 15um, the viable count of bacillus coagulans is more than or equal to 5 multiplied by 107CFU/g, and the pharmaceutically acceptable carrier is selected from any one or combination of gelatin, mannitol, sorbitol, xylitol, carrageenan, pectin, agar, guar gum, arabic gum, konjac gum, xanthan gum, sodium alginate, microcrystalline cellulose, starch, dextrin, polyvidone, starch slurry, sodium hydroxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, hydroxypropyl methyl cellulose, polyvinylpyrrolidone, sodium stearyl fumarate, sweetening agent, essence and pigment.
2. The pharmaceutical composition according to claim 1, wherein the composition comprises zinc gluconate.
3. The pharmaceutical composition according to claim 2, wherein the pharmaceutical active ingredients in the composition comprise calcium carbonate, vitamin D3, vitamin K2, bacillus coagulans, amino acid and zinc gluconate, and the ratio of calcium element: vitamin D3: vitamin K2: bacillus coagulans: amino acids: the weight ratio of the zinc gluconate to the zinc gluconate is 250:0.0025:0.02-0.04:15-50:80-130:15-50, the amino acid is selected from any one or combination of glutamic acid, glutamine, lysine hydrochloride and arginine, and the particle size of the calcium carbonate is less than or equal to 15um.
4. A pharmaceutical composition according to any one of claims 1 to 3, wherein the calcium carbonate has a particle size of 10 μm or less.
5. The pharmaceutical composition according to claim 1, wherein the viable count of Bacillus coagulans is 1X 10 or more 8 CFU/g。
6. The pharmaceutical composition according to claim 1, wherein the essence is selected from any one of lemon essence, apple essence, strawberry essence, mint essence, orange essence or a combination thereof.
7. The pharmaceutical composition of claim 1, wherein the sweetener is selected from any one of aspartame, glucose, sucrose, sodium cyclamate, lactose, fructose, acesulfame potassium, stevia, or combinations thereof.
8. The pharmaceutical composition of claim 1, wherein the pigment is selected from any one of lemon yellow, carmine, erythrosine, beet red, amaranth, indigo, curcumin, carotene, sunset yellow, complex black, fluorescent fruit green, or a combination thereof.
9. The pharmaceutical composition of claim 1, wherein the ratio of calcium carbonate: vitamin D3: vitamin K2: bacillus coagulans: glutamic acid: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.2:180:1250:5500:2000:1500:100:18.
10. The pharmaceutical composition of claim 1, wherein the ratio of calcium carbonate: vitamin D3: vitamin K2: bacillus coagulans: (ii) glutamine: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.3:200:1250:5500:2000:1500:100:18.
11. The pharmaceutical composition of claim 1, wherein the ratio of calcium carbonate: vitamin D3: vitamin K2: bacillus coagulans: lysine hydrochloride: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.4:300:1000:5500:2000:1500:100:18.
12. The pharmaceutical composition of claim 1, wherein the ratio of calcium carbonate: vitamin D3: vitamin K2: bacillus coagulans: arginine: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.4:300:1000:5500:2000:1500:100:18.
13. The pharmaceutical composition of claim 3, wherein the ratio of calcium carbonate: vitamin D3: vitamin K2: bacillus coagulans: zinc gluconate: glutamic acid: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.2:180:300:1250:5500:2000:1500:100:18.
14. The pharmaceutical composition of claim 3, wherein the ratio of calcium carbonate: vitamin D3: vitamin K2: bacillus coagulans: zinc gluconate: (ii) glutamine: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.3:200:280:1250:5500:2000:1500:100:18.
15. The pharmaceutical composition of claim 3, wherein the ratio of calcium carbonate: vitamin D3: vitamin K2: bacillus coagulans: zinc gluconate: lysine hydrochloride: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.4:300:260:1000:5500:2000:1500:100:18.
16. The pharmaceutical composition of claim 3, wherein the ratio of calcium carbonate: vitamin D3: vitamin K2: bacillus coagulans: zinc gluconate: arginine: gelatin: xylitol: mannitol: essence: the mass ratio of aspartame is 6250:0.025:0.4:300:350:1000:5500:2000:1500:100:18.
17. The process for preparing a pharmaceutical composition for the prevention and treatment of rickets as claimed in any one of claims 1 to 16, wherein said pharmaceutical composition comprises a pharmaceutically active ingredient and a pharmaceutically acceptable carrier, wherein said pharmaceutical active ingredient comprises calcium carbonate, vitamin D3, vitamin K2, bacillus coagulans and amino acids, and the ratio of calcium element: vitamin D3: vitamin K2: bacillus coagulans: the weight ratio of amino acid is 250:0.0025:0.02-0.04:15-50:80-130, the amino acid is selected from any one or the combination of glutamic acid, glutamine, lysine hydrochloride and arginine, the particle size of the calcium carbonate is less than or equal to 15um, and the viable count of the bacillus coagulans is more than or equal to 5 multiplied by 10 7 CFU/g, the pharmaceutically acceptable carrier is selected from any one or combination of gelatin, mannitol, sorbitol, xylitol, carrageenan, pectin, agar, guar gum, arabic gum, konjac gum, xanthan gum, sodium alginate, microcrystalline cellulose, starch, dextrin, polyvidone, starch slurry, sodium hydroxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, hydroxypropyl methyl cellulose, polyvinylpyrrolidone, sodium stearyl fumarate, a sweetener, essence and pigment, and the method comprises the following steps:
(1) Weighing required amounts of vitamin D3 and vitamin K2, stirring, dissolving in 95% ethanol solution, and spraying the prepared vitamin complex ethanol solution to calcium carbonate to obtain calcium carbonate containing vitamin complex;
(2) Weighing required amount of gelatin, stirring, swelling in required amount of water, stirring, heating to obtain gelatin solution, and keeping the temperature for use;
(3) Weighing the required amount of bacillus coagulans, amino acid and other pharmaceutically acceptable carriers except gelatin, stirring, uniformly mixing with calcium carbonate particles containing multivitamins, stirring, placing the prepared mixture into a gelatin solution, uniformly mixing, pouring into a mold, and drying under reduced pressure to obtain the calcium carbonate calcium coagulant.
18. The method of claim 17, wherein the composition comprises zinc gluconate.
19. The method of claim 18, wherein the pharmaceutically active ingredient in the composition comprises calcium carbonate, vitamin D3, vitamin K2, zinc gluconate, an amino acid and bacillus coagulans, wherein the ratio of calcium in the pharmaceutically active ingredient, calculated as calcium: vitamin D3: vitamin K2: amino acids: the weight ratio of the bacillus coagulans is 250:0.0025:0.02-0.04:15-50:80-130:15-50, the amino acid is selected from any one or combination of glutamic acid, glutamine, lysine hydrochloride and arginine, the particle size of the calcium carbonate is less than or equal to 15um, and the method comprises the following steps:
(1) Weighing required amounts of vitamin D3 and vitamin K2, stirring, dissolving in 95% ethanol solution, and spraying the prepared vitamin complex ethanol solution to calcium carbonate to obtain calcium carbonate containing vitamin complex;
(2) Weighing required amount of gelatin, stirring, swelling in required amount of water, stirring, heating to obtain gelatin solution, and keeping the temperature for use;
(3) Weighing the required amount of bacillus coagulans, zinc gluconate, amino acid and other pharmaceutically acceptable carriers except gelatin, stirring, uniformly mixing with calcium carbonate particles containing multivitamins, stirring, placing the prepared mixture into a gelatin solution, uniformly mixing, pouring into a mold, and drying under reduced pressure to obtain the calcium carbonate calcium complex.
20. The production process according to any one of claims 17 to 19, wherein the stirring conditions are 100rpm to 1000rpm.
21. The method of claim 20, wherein the stirring conditions are from 200rpm to 800rpm.
22. The method of claim 21, wherein the stirring conditions are 300rpm to 600rpm.
23. The method of claim 17 or 19, wherein the heating temperature is not less than 45 ℃.
24. The method of claim 23, wherein the heating temperature is not less than 50 ℃.
25. The method of claim 24, wherein the heating temperature is not less than 60 ℃.
26. The method of claim 17 or 19, wherein the drying temperature is 60 ℃ or less.
27. The method of claim 26, wherein the drying temperature is no greater than 50 ℃.
28. The method of claim 27, wherein the drying temperature is 45 ℃ or less.
29. Use of a pharmaceutical composition as claimed in any one of claims 1 to 16 or as prepared by a method as claimed in any one of claims 17 to 28 in the manufacture of a medicament for the prevention or treatment of any one of osteoporosis, rickets, growth and development disorders in children or complications thereof.
30. Use of a pharmaceutical composition according to any one of claims 1 to 16 or a pharmaceutical composition prepared by a process according to any one of claims 17 to 28 for the preparation of a calcium-or calcium-zinc-supplemented preparation.
31. The use of claim 29 or 30, wherein the pharmaceutical composition is for calcium or calcium zinc supplementation in the elderly, in children, in pregnant women, and in other people in need of calcium supplementation.
CN202210625483.9A 2022-05-30 2022-06-02 A pharmaceutical composition for preventing and treating rickets, and its preparation method Active CN114767719B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN202210604731 2022-05-30
CN2022106147339 2022-05-30
CN202210614733 2022-05-30
CN2022106047311 2022-05-30

Publications (2)

Publication Number Publication Date
CN114767719A CN114767719A (en) 2022-07-22
CN114767719B true CN114767719B (en) 2023-01-17

Family

ID=82422072

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210625483.9A Active CN114767719B (en) 2022-05-30 2022-06-02 A pharmaceutical composition for preventing and treating rickets, and its preparation method

Country Status (1)

Country Link
CN (1) CN114767719B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1060336C (en) * 1995-12-05 2001-01-10 孔彦平 Medicine for prevention and treatment of calcium deficiency and its prepn
WO2003094897A1 (en) * 2002-05-09 2003-11-20 Chugai Seiyaku Kabushiki Kaisha Photostabilized soft capsule
CN102578346B (en) * 2012-03-09 2013-11-06 华北制药集团新药研究开发有限责任公司 Lutein ester soft sweet and preparation method thereof
CN108478595B (en) * 2018-05-01 2021-07-02 海南施宝生物科技有限公司 A pharmaceutical composition containing calcium carbonate, vitamin D3, and vitamin K2
CN112353813A (en) * 2020-12-10 2021-02-12 浙江艾兰得生物科技有限公司 Vitamin D and vitamin K soft capsules with good calcium supplementing effect

Also Published As

Publication number Publication date
CN114767719A (en) 2022-07-22

Similar Documents

Publication Publication Date Title
US8518379B2 (en) Oral compositions for absorption of phosphorous compounds
RU2447933C2 (en) Phosphate adsorbent based on iron (iii) compounds and carbohydrates
US12070446B2 (en) Standardized psychoactive alkaloid extract composition
CN1994468A (en) Unfavorable taste-masking drug granule, chewable formulation and preparation process thereof
EP2627313A2 (en) Phosphate binder formulation for simple ingestion
EP1031345B1 (en) Gel preparation containing polystyrene-sulfonates
JPH0625064B2 (en) Controlled release potassium chloride
JP2818220B2 (en) Composition containing water-containing organic solvent extract for food, composition containing water-containing organic solvent extract for medicine, and methods for producing them
JP2016174616A (en) Disintegrable composition, and easily disintegrable compression molding
CN104940301A (en) Pudilan children&#39;s antiviral oral pellet gel and preparation method thereof
Cacek Review of alterations in oral phenytoin bioavailability associated with formulation, antacids, and food
WO2005112881A1 (en) The dispersible montmorillonite tablet and its preparation technology
CN115089618B (en) A pharmaceutical composition for preventing and treating osteoporosis, and its preparation method
JPH0465051B2 (en)
CN106963777A (en) A kind of preparation method and applications of &#34; scutelloside jamaicin &#34; compound
JPH06219939A (en) Rotating tablet-forming and taste-covering coating processing for preparing chewable medical tablet
CN114767719B (en) A pharmaceutical composition for preventing and treating rickets, and its preparation method
JP5327682B2 (en) Pharmaceutical composition used as laxative
CN106822907B (en) Two-phase release preparation containing racecadotril and preparation method thereof
CN102100902B (en) Counterflow effervescent tablets
CN108420890B (en) Composition with blood fat reducing effect and preparation method thereof
CN111617042A (en) Composite calcium carbonate vitamin D3Water-free swallow granule and preparation method thereof
CN114832020B (en) Pharmaceutical composition for preventing and treating child developmental disorder and preparation method thereof
US20030108605A1 (en) Mineral supplement
CN112891448A (en) Colloidal bismuth pectin preparation for treating superficial gastritis and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant