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CN114728925A - 一种作为ssao/vap-1抑制剂的胺类衍生物及其用途 - Google Patents

一种作为ssao/vap-1抑制剂的胺类衍生物及其用途 Download PDF

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Publication number
CN114728925A
CN114728925A CN201980102424.XA CN201980102424A CN114728925A CN 114728925 A CN114728925 A CN 114728925A CN 201980102424 A CN201980102424 A CN 201980102424A CN 114728925 A CN114728925 A CN 114728925A
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compound
atoms
radical
deuterium
group
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CN201980102424.XA
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CN114728925B (zh
Inventor
顾峥
黎健豪
王伟华
覃浩雄
李峥
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Sunshine Lake Pharma Co Ltd
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Sunshine Lake Pharma Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

一种作为SSAO/VAP‑1抑制剂的胺类衍生物及其用途,进一步涉及包含所述化合物的药物组合物。化合物或药物组合物可用于治疗炎症和/或炎症相关疾病或糖尿病和/或糖尿病相关疾病。

Description

PCT国内申请,说明书已公开。

Claims (13)

  1. PCT国内申请,权利要求书已公开。
CN201980102424.XA 2019-11-28 2019-11-28 一种作为ssao/vap-1抑制剂的胺类衍生物及其用途 Active CN114728925B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/121469 WO2021102774A1 (zh) 2019-11-28 2019-11-28 一种作为ssao/vap-1抑制剂的胺类衍生物及其用途

Publications (2)

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CN114728925A true CN114728925A (zh) 2022-07-08
CN114728925B CN114728925B (zh) 2023-12-08

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CN201980102424.XA Active CN114728925B (zh) 2019-11-28 2019-11-28 一种作为ssao/vap-1抑制剂的胺类衍生物及其用途

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CN (1) CN114728925B (zh)
WO (1) WO2021102774A1 (zh)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1921841A (zh) * 2004-02-25 2007-02-28 拉卓拉药物公司 用于治疗疾病的胺和酰胺类化合物
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1863763A (zh) * 2003-08-08 2006-11-15 拉卓拉药物公司 用于治疗疾病的氨基脲敏感性胺氧化酶(ssao)和vap-1介导的粘着的抑制剂
ME03063B (me) * 2012-05-02 2019-01-20 Boehringer Ingelheim Int Supstituisani 3-haloalilamin inhibitori ssao i njihove primene

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1921841A (zh) * 2004-02-25 2007-02-28 拉卓拉药物公司 用于治疗疾病的胺和酰胺类化合物
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases

Also Published As

Publication number Publication date
WO2021102774A1 (zh) 2021-06-03
CN114728925B (zh) 2023-12-08

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