CN114652619A - Active oil-soluble anthocyanin and preparation method and application thereof - Google Patents
Active oil-soluble anthocyanin and preparation method and application thereof Download PDFInfo
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- CN114652619A CN114652619A CN202210497535.9A CN202210497535A CN114652619A CN 114652619 A CN114652619 A CN 114652619A CN 202210497535 A CN202210497535 A CN 202210497535A CN 114652619 A CN114652619 A CN 114652619A
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- anthocyanin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A61Q1/02—Preparations containing skin colorants, e.g. pigments
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Abstract
The invention discloses an active oil-soluble anthocyanin and a preparation method and application thereof, wherein the active oil-soluble anthocyanin is prepared by cross-linking and embedding 100-300 parts by weight of functional components, 50-150 parts by weight of oil phase components, 40-100 parts by weight of emulsifying components and 10-30 parts by weight of active components, the functional components are the anthocyanin, the oil phase components are one or more of cannabis oil, rose essential oil and camellia oil, the emulsifying components are one or more of methyl glucose sesquistearate, fatty acid sucrose polyester and coco-oil glucoside, and the active components are edible fungus extracts and comprise the following components: tremella extract, flammulina velutipes extract and bolete extract. The active oil-soluble anthocyanin prepared by the invention is dark red in appearance, transparent and good in fluidity, can be easily added into oil phases or anhydrous formulas of various cosmetics and functional foods, can be quickly and uniformly dispersed in the oil phases, is not easy to aggregate and precipitate, and has no obvious granular sensation.
Description
Technical Field
The invention relates to anthocyanin and a preparation method and application thereof, in particular to active oil-soluble anthocyanin and a preparation method thereof, and belongs to the technical field of anthocyanin.
Background
Anthocyanins (anthocyanins) are water-soluble natural pigments, and have the main physiological activities of antioxidant capacity and free radical scavenging capacity, wherein the antioxidant capacity is 50 times that of vitamin E and 20 times that of vitamin C. The blueberry anthocyanin content is over 0.36 percent, the blueberry anthocyanin contains 15 different anthocyanin components, the common blueberry anthocyanin content is about 0.10 percent and only contains 1 to 5 anthocyanin components, the more anthocyanin components, the stronger anthocyanin has the effects of oxidation resistance, inflammation resistance and the like, and the blueberry anthocyanin has the effects of strengthening capillary vessels, improving blood circulation, preventing thrombosis and the like. The anthocyanin belongs to natural plant pigment, overcomes the defect that the existing chemical pigment is harmful to human, so that the cowberry fruit is not only a health food, but also is more suitable for developing skin-care and beauty products.
The anthocyanin has strong polarity and low solubility in oil products, and is easy to agglomerate, agglomerate or precipitate when being directly added into an oil phase system, so that the application of the water-soluble anthocyanin in products such as lipstick and lipstick which take oil and lipid as main components is prevented. At present, a technology for solving the problem of application of a water-soluble substance such as sodium hyaluronate in an oil phase system exists, and Chinese patent 200710044082.X embeds an aqueous solution of sodium hyaluronate in water-in-oil type nanoparticles, but the technology adopts a chemical synthetic material as a wall material, cannot be absorbed and utilized by skin, has low total content and encapsulation rate of sodium hyaluronate, is unstable in structure, is easily broken under the influence of temperature and shearing force in the application process, and has influenced biological activity, so that a terminal product is unstable. For example, when the microencapsulation technology is applied in the field, the problems of low embedding rate of contents, poor safety of wall materials, low absorption utilization rate, poor stability of microcapsules and the like are frequently encountered, and anthocyanin is sensitive to temperature, illumination and humidity and has poor stability. Therefore, the application of the water-soluble substance in the oil phase system is restricted in various aspects.
At present, no research on water-soluble anthocyanin in an oil phase system is reported, and the application of the anthocyanin in an oily product is little and less. Therefore, there is a need to develop a technology that can effectively realize uniform diffusion of water-soluble anthocyanin in an oil phase system and maintain high biological activity.
Disclosure of Invention
In order to solve the problem that the water-soluble anthocyanin cannot be uniformly diffused into an oil phase system, the invention aims to provide the active oil-soluble anthocyanin and the preparation method and the application thereof.
In order to achieve the above object, the present invention adopts the following technical solutions:
the active oil-soluble anthocyanin is characterized by being prepared by cross-linking and embedding 100-300 parts by weight of functional components, 50-150 parts by weight of oil phase components, 40-100 parts by weight of emulsifying components and 10-30 parts by weight of active components, wherein:
the functional component is anthocyanin;
the oil phase component is one or more of cannabis oil, rose essential oil and camellia oil;
the emulsifying component is one or more of methyl glucose sesquistearate, fatty acid sucrose polyester and coco glucoside;
the active component is edible fungus extract, and comprises: tremella extract, needle mushroom extract and bolete extract.
The preparation method of the active oil-soluble anthocyanin is characterized by comprising the following steps:
(1) heating and melting the emulsified components to obtain an emulsified liquid, and keeping the temperature for later use, preferably, keeping the temperature at 45-60 ℃;
(2) uniformly mixing the functional component and the active component, adding the oil phase component, stirring and homogenizing, and performing crosslinking embedding to obtain a crosslinked substance, wherein the conditions of the crosslinking embedding are as follows: performing ultrasonic treatment at 40-50 ℃ for 10min, magnetically stirring for 30min, and homogenizing for 1 time at 30 MPa;
(3) and (3) uniformly mixing the cross-linked product and the emulsion at the same temperature, homogenizing, and cooling to obtain the active oil-soluble anthocyanin, wherein the preferred mixing temperature is 45-50 ℃, the homogenizing condition is 30MPa, and the cooling temperature is 5-10 ℃.
The application of the active oil-soluble anthocyanin in beauty cosmetics, dairy products and functional foods.
The application is characterized in that the preparation of the active oil-soluble anthocyanin lipstick/lipstick by using the active oil-soluble anthocyanin specifically comprises the following steps:
(1) uniformly mixing 100-200 parts by weight of olive oil, 80-120 parts by weight of sunflower seed oil, 70-100 parts by weight of chinlon oil, 50-100 parts by weight of ginger oil and 10-20 parts by weight of aloe oil to obtain a suspension A, heating, and keeping the temperature for later use, wherein the preferable temperature is 45-60 ℃;
(2) mixing 40-60 parts by weight of white beeswax, 50-80 parts by weight of yellow beeswax and 20-50 parts by weight of candelilla wax, heating to melt to obtain a suspension B, and keeping the temperature for later use, preferably, keeping the temperature at 45-60 ℃;
(3) mixing the suspension A and the suspension B at the same temperature to obtain a suspension C;
(4) adding 10-50 parts by weight of the active oil-soluble anthocyanin as defined in claim 1, 5-20 parts by weight of natural bioactive antibacterial peptide, 5-10 parts by weight of vitamin D and 20-50 parts by weight of orange honey into the suspension C, homogenizing under high pressure, and degassing in a vacuum drying oven under reduced pressure to obtain a mixture, wherein the homogenizing under high pressure is carried out for 2 times under the condition of 30 MPa;
(5) and (4) quickly pouring the mixture obtained in the step (4) into a lipstick mould and cooling, and demoulding to obtain the active oil-soluble anthocyanin lipstick, or quickly pouring the mixture into a lipstick tank and cooling to obtain the active oil-soluble anthocyanin lipstick.
The invention has the advantages that:
(1) the active oil-soluble anthocyanin prepared by the invention is dark red in appearance, transparent and good in fluidity, can be easily added into oil phases or anhydrous formulas of various cosmetics and functional foods, can be rapidly and uniformly dispersed in the oil phases, is not easy to aggregate and precipitate, and has no obvious granular feeling;
(2) the active oil-soluble anthocyanin prepared by the invention contains the edible fungus extract, the edible fungus extract and the anthocyanin have good cross-linking property and the characteristics of good antibiosis, antioxidation and the like, so that the stability of the anthocyanin can be well improved;
(3) the preparation method of the active oil-soluble anthocyanin provided by the invention is simple to operate, easy to control and low in preparation cost, the prepared active oil-soluble anthocyanin is uniformly diffused, the activity stability is high, the content of the active ingredient anthocyanin is high, and the active oil-soluble anthocyanin is easy to mutually blend with other ingredients in a terminal product formula;
(4) the active oil-soluble anthocyanin lipstick/lipstick prepared by the invention has the effects of oxidation resistance, moisture retention and moistening, can improve the fine lines, hardness and glossiness of lip skin, and has high ductility and smooth skin feel; the components are natural extracted components, and the natural bioactive antibacterial peptide-nisin is used, so that the natural bioactive antibacterial peptide-nisin is safe and healthy, and can achieve the effects of preventing corrosion, inhibiting bacteria and inhibiting pathogenic microorganisms without adding a preservative.
Drawings
FIG. 1 is a graph showing the temperature stability of anthocyanin after the procyanidin, anthocyanin microemulsion A and anthocyanin particles G are kept at 4 ℃ in the dark for 7 days;
FIG. 2 is a graph showing the temperature stability of anthocyanin after the procyanidin, anthocyanin microemulsion A and anthocyanin particles G are kept at 25 ℃ for 7 days in the dark;
FIG. 3 is a graph showing the temperature stability of anthocyanin after keeping procyanidin, anthocyanin microemulsion A and anthocyanin particles G away from light and for 7 days at 60 ℃;
FIG. 4 is a graph showing the light stability of anthocyanidin after procyanidin, anthocyanidin microemulsion A, and anthocyanidin particles G are stored in natural light at 25 ℃ for 7 days;
FIG. 5 is a graph showing the scavenging of DPPH free radicals after 30min reaction of procyanidin, anthocyanin microemulsion A, and vitamin C at different concentrations;
FIG. 6 is a graph showing that DPPH free radicals are removed by proanthocyanidin, anthocyanin microemulsion A and vitamin C within 7min of reaction with IC50 as an additive concentration;
FIG. 7 is a graph of water loss from the skin of the lips of a subject who was coated with active oil-soluble anthocyanin lipstick A and a commercially available brand of lipstick, as well as those who were not coated with lipstick;
FIG. 8 is a graph of lip skin hydration for subjects who were coated with active oil-soluble anthocyanin lipstick A and a commercially available brand of lipstick, as well as those who were not coated with lipstick.
Detailed Description
The invention is described in detail below with reference to the figures and the embodiments.
Preparation of active oil-soluble anthocyanin
Example 1
(1) Weighing 100 parts of anthocyanin, 50 parts of hemp seed oil, 40 parts of methyl glucose sesquistearate and 10 parts of tremella extract according to parts by weight;
(2) heating methyl glucose sesquistearate to 45 ℃ to melt the methyl glucose sesquistearate to obtain emulsion, and keeping the temperature at 45 ℃ for later use;
(3) mixing anthocyanidin and Tremella fuciformis extract uniformly, adding cannabis oil, stirring for homogenizing, and performing crosslinking embedding to obtain a crosslinked substance, wherein the conditions of crosslinking embedding are as follows: ultrasonic treating at 45 deg.C for 10min, magnetically stirring for 30min, and homogenizing at 30MPa for 1 time;
(4) and (3) uniformly mixing the cross-linked product and the emulsion at 45 ℃, homogenizing for 2 times under 30MPa, and cooling to the normal temperature at 5 ℃ to obtain the active oil-soluble anthocyanin (microemulsion), which is marked as anthocyanin microemulsion A.
During the process of preparing the active oil-soluble anthocyanin, the edible fungus extract (tremella extract, flammulina velutipes extract and bolete extract) is used as an active component to embed the functional component anthocyanin to form a compact and stable cross-linked structure, so that the functional component anthocyanin can be promoted to be blended with the oil phase and the emulsified component, the stable state of the nano-particles can be maintained, the functional component anthocyanin can be protected from being interfered by external factors, and the biological activities of the active oil-soluble anthocyanin such as oxidation resistance, bacteriostasis and the like can be improved.
Through detection, after the edible fungus extract and anthocyanin are cross-linked and embedded, the embedding rate reaches 82.7%, and under the same embedding condition, the embedding rate of conventional substances such as cyclodextrin, Arabic gum and the like on anthocyanin is only 61.3%. After the two cross-linked substances are respectively placed indoors (at 25 ℃ and without light) for 14 days, the degradation rates of the anthocyanin are respectively detected to be 11.7 percent and 28.3 percent. This indicates that: the edible fungus extract (Tremella extract, needle Mushroom extract, and Boletus extract) and anthocyanidin have good cross-linking property, and the cross-linked product has high stability.
Through further detection, the active oil-soluble anthocyanin prepared by the invention has good oil solubility, high dispersibility and high stability.
Example 2
Weighing 200 parts of anthocyanin, 100 parts of cannabis sativa oil, 70 parts of methyl glucose sesquistearate and 20 parts of tremella extract according to parts by weight, and preparing the active oil-soluble anthocyanin (microemulsion) by the same method as the example 1, wherein the active oil-soluble anthocyanin is marked as anthocyanin microemulsion B.
Example 3
Weighing 300 parts of anthocyanin, 150 parts of cannabis sativa oil, 100 parts of methyl glucose sesquistearate and 30 parts of tremella extract according to parts by weight, and preparing the active oil-soluble anthocyanin (microemulsion) by the same method as the example 1, wherein the active oil-soluble anthocyanin is marked as anthocyanin microemulsion C.
Example 4
Weighing 150 parts of anthocyanin, 80 parts of rose essential oil, 60 parts of fatty acid sucrose polyester and 10 parts of needle mushroom extract according to parts by weight, and preparing the active oil-soluble anthocyanin (microemulsion) by adopting the same method as the embodiment 1, wherein the active oil-soluble anthocyanin is marked as anthocyanin microemulsion D.
Example 5
Weighing 250 parts of anthocyanin, 120 parts of camellia oil, 80 parts of coco glucoside and 25 parts of bolete extract according to parts by weight, and preparing the active oil-soluble anthocyanin (microemulsion) by adopting the same method as the embodiment 1, wherein the active oil-soluble anthocyanin is marked as anthocyanin microemulsion E.
Example 6
Weighing 280 parts of anthocyanin, 140 parts of cannabis sativa oil, 90 parts of fatty acid sucrose polyester and 30 parts of bolete extract according to parts by weight, and preparing the active oil-soluble anthocyanin (microemulsion) by the same method as the example 1, wherein the active oil-soluble anthocyanin is marked as anthocyanin microemulsion F.
Comparative example 1
The difference from example 1 is that: the formula does not contain active components, and no crosslinking embedding operation step is needed in the preparation process.
(1) Weighing 100 parts of anthocyanin, 50 parts of hemp seed oil and 40 parts of methyl glucose sesquistearate in parts by weight;
(2) respectively heating the hemp oil and the methyl glucose sesquistearate to 45 ℃, and preserving heat for later use;
(3) mixing oleum Sesami and methyl glucose sesquistearate at 45 deg.C, stirring, adding anthocyanidin, and homogenizing at 30MPa for 3 times to obtain anthocyanidin granule, which is designated as anthocyanidin granule G.
Comparative example 2
The difference from example 4 is that: the formula does not contain emulsified components, and no crosslinking embedding operation step is needed in the preparation process.
(1) Weighing 150 parts of anthocyanin, 80 parts of rose essential oil and 10 parts of needle mushroom extract in parts by weight;
(2) heating rose essential oil and needle mushroom extract to 45 deg.C respectively, and keeping the temperature for use;
(3) mixing rose essential oil and needle mushroom extract at 45 deg.C, stirring, adding anthocyanidin, and homogenizing at 30MPa for 3 times to obtain anthocyanidin granule, which is designated as anthocyanidin granule H.
Secondly, identification and performance research of active oil-soluble anthocyanin
1. Identification of active oil-soluble anthocyanins
(1) Centrifugal experiment
The active oil-soluble anthocyanin (anthocyanin microemulsion) prepared in the embodiments 1 to 6 is respectively placed in a centrifuge tube, the anthocyanin particles prepared in the comparative examples 1 and 2 are firstly added into absolute ethyl alcohol to prepare solutions, then the solutions are respectively placed in the centrifuge tube, the centrifuge tube is centrifuged at 4000r/min for 30min, and whether the layering phenomenon occurs in each centrifuge tube is observed. If the layering phenomenon does not occur, the nano particles are prepared; if the delamination occurs, then either nanoparticles or incomplete nanoparticles are produced.
The experimental results are as follows:
(i) the active oil-soluble anthocyanidin (anthocyanin microemulsion) prepared in the examples 1 to 6 has no layering phenomenon after centrifugation, and the active oil-soluble anthocyanidin prepared in the examples 1 to 6 is proved to be nanoparticles;
(ii) the anthocyanin particles prepared in comparative example 1 and comparative example 2 (after being prepared into a solution) both showed slight delamination after centrifugation, and the degree of delamination of comparative example 2 was higher than that of comparative example 1, confirming that the anthocyanin particles prepared in comparative example 1 and comparative example 2 were incomplete nanoparticles.
It can be seen that, when the active oil-soluble anthocyanin is prepared, the stability of the nanoparticles is affected if the active component or the emulsifying component is not added, and the effect of the emulsifying component is greater than that of the active component.
(2) Root of Dikou Er Effect
The active oil-soluble anthocyanins (anthocyanidin microemulsions) prepared in examples 1 to 6 were placed in glass test tubes, and the anthocyanins particles prepared in comparative examples 1 and 2 were added to absolute ethanol to prepare solutions, and then placed in glass test tubes, stored in a dark room, irradiated with a straight light, and observed for light scattering. If the light scattering phenomenon occurs, the prepared nano particles are not nano particles or incomplete nano particles; if no light scattering phenomenon occurs, the prepared nano particles are obtained.
The experimental results are as follows:
(i) after light passes through the active oil-soluble anthocyanin (anthocyanin microemulsion) prepared in examples 1 to 6, no light scattering phenomenon occurs, and the nanoparticles prepared in examples 1 to 6 are proved;
(ii) after light passes through the anthocyanin particles prepared in comparative example 1 and comparative example 2 (prepared into solution), a light scattering phenomenon appears, and the anthocyanin particles prepared in comparative example 1 and comparative example 2 are proved to be incomplete nanoparticles.
(3) Determination of particle size and polydispersity index
The particle size and polydispersity index (PDI) of the samples (the active oil-soluble anthocyanins prepared in examples 1 to 6, the anthocyanidin particles prepared in comparative examples 1 and 2) were measured at 25 ℃ using a malverlaser light scattering instrument.
The experimental results are as follows:
TABLE 1 particle size and polydispersity index of the samples
| Item group | Particle size (nm) | Polydispersity index |
| Example 1 | 24.3 | 0.38 |
| Example 2 | 18.47 | 0.31 |
| Example 3 | 14.22 | 0.25 |
| Example 4 | 22.1 | 0.28 |
| Example 5 | 17.37 | 0.3 |
| Example 6 | 14.58 | 0.26 |
| Comparative example 1 | 27.2 | 0.24 |
| Comparative example 2 | 36.75 | 0.22 |
As can be seen from Table 1:
(i) the particle size distribution of the active oil-soluble anthocyanin (anthocyanin microemulsion) prepared in the examples 1 to 6 is 14-24 nm, and the polydispersity index (PDI) is small, so that the particle size distribution of the active oil-soluble anthocyanin prepared in the examples 1 to 6 is relatively uniform;
(ii) the particle size of the anthocyanin particles prepared in comparative example 1 and comparative example 2 is larger than 24nm, and the polydispersity index (PDI) is smaller, which indicates that the particle size distribution of the anthocyanin particles prepared in comparative example 1 and comparative example 2 is more uniform and larger than the particle size of the active oil-soluble anthocyanins prepared in examples 1 to 6.
It can be seen that the anthocyanin particles prepared in comparative example 1 and comparative example 2 are weaker in particle size and polydispersity index than the active oil-soluble anthocyanins prepared in examples 1 to 6.
2. Temperature stability of active oil-soluble anthocyanins
Taking procyanidin, the anthocyanin microemulsion A prepared in example 1 and the anthocyanin particle G prepared in comparative example 1, and keeping the temperature at 4 ℃, 25 ℃ and 60 ℃ for 7 days in a dark place respectively to detect the temperature stability of the anthocyanin.
The results of the measurements are shown in FIGS. 1, 2 and 3.
As can be seen from fig. 1, 2 and 3:
(i) the anthocyanin can be stored for a long time at 4 ℃, and the retention rate of the anthocyanin is kept above 92% after 7 days;
(ii) at the room temperature of 25 ℃, the stability of the anthocyanin is reduced, wherein the reduction trend of the anthocyanin microemulsion A is the minimum, the anthocyanin retention rate is kept between 80-90%, and no large stability difference occurs;
(iii) at 60 ℃, the stability of the anthocyanin is obviously changed, the retention rate of the procyanidin is only 64.8%, and the retention rate of the anthocyanin microemulsion A is 82.2%.
This indicates that: the temperature stability of the anthocyanin treated by the active oil solution is obviously improved.
3. Light stability of active oil-soluble anthocyanins
Taking procyanidin, the anthocyanin microemulsion A prepared in example 1 and the anthocyanin particles G prepared in comparative example 1, storing the procyanidin, the anthocyanin microemulsion A prepared in example 1 and the anthocyanin particles G in natural light at 25 ℃ for 7 days, and detecting the illumination stability of the anthocyanin.
The results are shown in FIG. 4.
As can be seen from fig. 4: after being stored for 7 days at 25 ℃ under natural light, the anthocyanin micro emulsion A has the anthocyanin retention rate of 72.6 percent, the anthocyanin particle G retention rate of 62.5 percent and the procyanidin retention rate of 21.4 percent.
Comparing fig. 2 and fig. 4, it can be seen that: after the photosensitive anthocyanin is subjected to active oil dissolving treatment, the high illumination stability can be still kept under natural light.
4. Antioxidant activity of active oil-soluble anthocyanidin
Anthocyanins are natural antioxidants and they are primarily used as free radical inhibitors to protect the body. The experiments for removing DPPH free radicals, ABTS free radicals, superoxide anions and the like are usually used as the antioxidant evaluation of active substances, and the antioxidant activity of the active oil-soluble anthocyanin is verified through the DPPH free radical removal effect.
DPPH is a stable free radical with a maximum absorption peak at 517 nm. The radical scavenger binds to DPPH radicals, and the bound species has an absorption maximum at 517 nm. Therefore, the change of the light absorption value can be detected by adopting a spectrophotometry method, and the size of the DPPH removing energy of the active substance can be further judged. The invention takes vitamin C as a positive control to detect the free radical clearance rate of anthocyanin microemulsion A and procyanidine.
The results are shown in FIGS. 5 and 6.
As can be seen from fig. 5:
(i) the DPPH free radical scavenging capacity of the anthocyanin microemulsion A, the procyanidine and the vitamin C is enhanced along with the increase of the concentration;
(ii) at low concentrations, the free radical clearance of vitamin C is slightly higher than that of procyanidins;
(iii) under high concentration, the free radical clearance rate of the procyanidin and anthocyanin microemulsion A is increased slowly, and finally the clearance rate of the procyanidin to the free radicals is slightly higher than that of the vitamin C, while the clearance rate of the anthocyanin microemulsion A to the free radicals is basically consistent with that of the vitamin C.
This indicates that: the oxidation resistance of the anthocyanin treated by the active oil solution is not obviously changed.
As can be seen from fig. 6: vitamin C rapidly reaches half the clearance rate, while procyanidin and anthocyanin microemulsion A react slowly, and the maximum effect is reached after 7 min.
The anthocyanin microemulsion A has longer reaction time, which is caused by the slow release effect of the nano particles. Therefore, the nano-particle embedded anthocyanin has a good promotion effect on the improvement of DPPH free radical scavenging capacity.
Application of active oil-soluble anthocyanin
The active oil-soluble anthocyanin prepared by the invention can be applied to oil phase or anhydrous formulas of beauty cosmetics such as lipstick, lip gloss, lipstick, blush and the like, dairy products and functional foods.
1. Preparation of active oil-soluble anthocyanin lipstick/lipstick
Lipstick/lip balm is one kind of lip cosmetic, and has the functions of moistening and protecting lip and making lip ruddy and glossy. The main components of lipstick/lip balm in the current market are all composed of base raw materials such as oil, wax, softener and the like, and auxiliary materials such as pigment, surfactant, spice and the like, so that many manufacturers seek benefits and reduce cost, adopt low-price inferior raw materials such as colorant containing lead and other heavy metals, industrial pigment, synthetic essence, preservative and the like, and the lipstick/lip balm smeared on lips can be taken into the body carelessly, so that serious potential safety hazard exists, and the safety of the lipstick/lip balm is particularly important. Therefore, there is a need to develop a green, healthy, edible lipstick/lip balm.
The lipstick/lipstick containing the active oil-soluble anthocyanin is prepared by utilizing the active oil-soluble anthocyanin prepared in the previous step and other natural plant components, can lubricate lip mucosa, remove free radicals, improve skin fine lines, hardness and smoothness, is non-toxic to human bodies, does not generate anaphylactic reaction, and is edible in deed.
The formula of the active oil-soluble anthocyanin lipstick/lipstick is as follows:
the feed additive comprises, by weight, 100-200 parts of olive oil, 80-120 parts of sunflower seed oil, 70-100 parts of white Potentilla seed oil, 5-10 parts of vitamin D, 20-50 parts of orange honey, 50-100 parts of ginger oil, 40-60 parts of white beeswax, 50-80 parts of yellow beeswax, 20-50 parts of candelilla wax, 10-20 parts of aloe oil, 5-20 parts of natural bioactive antibacterial peptide and 10-50 parts of active oil anthocyanidin.
The natural bioactive antibacterial peptide is nisin, which is a polypeptide substance, can be quickly hydrolyzed into amino acid in a human digestive system, does not change normal flora in human intestinal tracts, does not generate resistance problems like other antibiotics, and is a natural food preservative with high efficiency, no toxicity, safety and no side effect.
Example 1
The formula is as follows: the skin care cream comprises, by weight, 100 parts of olive oil, 80 parts of sunflower seed oil, 70 parts of white chinlon oil, 5 parts of vitamin D, 20 parts of orange honey, 50 parts of ginger oil, 40 parts of white beeswax, 50 parts of yellow beeswax, 20 parts of candelilla wax, 10 parts of aloe oil, 5 parts of natural bioactive antibacterial peptide (nisin) and 10 parts of active oil-soluble anthocyanin (anthocyanin microemulsion A).
The preparation process of the active oil-soluble anthocyanin lipstick comprises the following steps:
(1) mixing oleum Olivarum, oleum Helianthi, white Potentilla chinensis seed oil, rhizoma Zingiberis recens oil and Aloe oil uniformly to obtain suspension A, heating, and keeping at 50 deg.C;
(2) mixing white beeswax, yellow beeswax and candelilla wax, heating to melt to obtain suspension B, and keeping the temperature at 50 ℃ for later use;
(3) mixing the suspension A and the suspension B at the same temperature to obtain a suspension C;
(4) adding active oil-soluble anthocyanin, natural bioactive antibacterial peptide, vitamin D and orange honey into the suspension C, homogenizing for 2 times under 30MPa, and degassing in a vacuum drying oven under reduced pressure to obtain a mixture;
(5) and (5) quickly pouring the mixture obtained in the step (4) into a lipstick mould, cooling, and demoulding to obtain the active oil-soluble anthocyanin lipstick, which is marked as active oil-soluble anthocyanin lipstick A.
The preparation method of the active oil soluble anthocyanin lipstick is basically the same as that of the active oil soluble anthocyanin lipstick, the difference is only in the step (5), a lipstick mould is not used, demoulding is not needed, and the specific steps are as follows: and (5) quickly pouring the mixture obtained in the step (4) into a lipstick tank and cooling to obtain the active oil-soluble anthocyanin lipstick.
Example 2
The formula is as follows: the skin care cream comprises, by weight, 150 parts of olive oil, 100 parts of sunflower seed oil, 90 parts of white Poissa seed oil, 8 parts of vitamin D, 30 parts of orange honey, 70 parts of ginger oil, 50 parts of white beeswax, 70 parts of yellow beeswax, 30 parts of candelilla wax, 15 parts of aloe oil, 10 parts of natural bioactive antibacterial peptide (nisin) and 30 parts of active oil-soluble anthocyanin (anthocyanin microemulsion A).
The preparation process of the active oil-soluble anthocyanin lipstick is the same as that of the example 1 and is not repeated. The prepared active oil-soluble anthocyanin lipstick is marked as active oil-soluble anthocyanin lipstick B.
Example 3
The formula is as follows: the skin care cream comprises, by weight, 200 parts of olive oil, 120 parts of sunflower seed oil, 100 parts of white chinlon oil, 10 parts of vitamin D, 50 parts of orange honey, 100 parts of ginger oil, 60 parts of white beeswax, 80 parts of yellow beeswax, 50 parts of candelilla wax, 20 parts of aloe oil, 20 parts of natural bioactive antibacterial peptide (nisin) and 50 parts of active oil-soluble anthocyanin (anthocyanin microemulsion A).
The preparation process of the active oil-soluble anthocyanin lipstick is the same as that of the example 1 and is not repeated. The prepared active oil-soluble anthocyanin lipstick is marked as active oil-soluble anthocyanin lipstick C.
2. Evaluation of active oil-soluble anthocyanin lipstick
(1) Sensory evaluation
Selecting the crowds of different age groups as the members of the appraisal group, ensuring the other conditions to be the same, carrying out sensory scoring on the sample from four aspects of chromaticity, extensibility, moistening degree and moisturizing effect, wherein the total score is 10, the score is very good, better, acceptable and completely unacceptable for 4 grades, and the score and the corresponding condition of the grades are as follows:
| score of | Grade |
| Not less than 8 points | Is very good |
| From 6 (inclusive) to 8 minutes | Is better |
| 5 (inclusive) to 6 minutes | Can accept |
| <5 points of | Is totally unacceptable |
The active oil-soluble anthocyanin lipstick a prepared in example 1, the active oil-soluble anthocyanin lipstick B prepared in example 2, the active oil-soluble anthocyanin lipstick C prepared in example 3 and a commercially available brand lipstick were used for a total of 40 subjects, and the score was filled in the form of a scale, and the sensory score was shown in table 2.
TABLE 2 sensory scores
| Test item | Color of upper color | Ductility of the alloy | Moistening degree | Moisturizing effect |
| Active oil-soluble |
8 is divided into | 9 |
10 |
9 minutes |
| Active oil-soluble |
9 |
9 points of | 9 |
9 points of |
| Active oil-soluble |
9 |
8 is divided into | 9 |
9 minutes |
| Commercially available lipstick of |
7 points of | 8 is divided into | 7 points of | 6 points of |
According to the evaluation and scoring results of testees, the active oil-soluble anthocyanin lipstick provided by the invention has good color extension after being applied and has good effects on moisture retention and moistening degree.
(2) Moisture test and evaluation
After a human subject is respectively smeared with the active oil-soluble anthocyanin lipstick A, the active oil-soluble anthocyanin lipstick B and the active oil-soluble anthocyanin lipstick C for 1 hour, the change of the water content of the lip skin and the change of the water shunt loss are respectively as follows:
(i) after a tested person is smeared with the active oil-soluble anthocyanin lipstick A1h, the water content of the skin of the lips is rapidly improved by 149.1 percent, and the water diversion loss is reduced by 30.7 percent;
(ii) after a tested person is smeared with the active oil-soluble anthocyanin lipstick B1h, the water content of the skin of the lips is rapidly improved by 135.2 percent, and the water diversion loss is reduced by 42 percent;
(iii) after a tested person is smeared with the active oil-soluble anthocyanin lipstick C1h, the water content of the skin of the lips is rapidly improved by 146.4 percent, and the water diversion loss is reduced by 35.8 percent.
This indicates that: the active oil-soluble anthocyanin lipstick prepared by the invention has obvious moisturizing effect.
Selecting people of different ages as members of an identification group, ensuring the other conditions to be the same, evenly dividing the test persons into three groups, wherein each group comprises 10 persons, the first group of test persons are smeared with the active oil-soluble anthocyanin lipstick A (experimental group) prepared in the embodiment 1, the second group of test persons are smeared with a certain brand of lipstick (control group) on the market, the third group of test persons are not smeared with the lipstick (blank control group), and detecting the water content and the water loss of the lip skin of the test subject every 2 hours.
The results are shown in FIGS. 7 and 8. Fig. 7 and 8 show that: the active oil-soluble anthocyanin lipstick prepared by the invention has obvious moisturizing effect.
In conclusion, the active oil-soluble anthocyanin prepared by the invention is easy to add into the oil phase and the anhydrous formula, can be rapidly and uniformly dispersed in the oil phase and the anhydrous formula, is not easy to aggregate and precipitate, and has no obvious granular feeling; the active oil-soluble anthocyanin lipstick prepared by the invention can lubricate lip mucosa, remove active oxygen free radicals, improve fine lines, hardness, glossiness and smoothness of skin, has a protection effect on skin photoaging caused by ultraviolet rays, is non-toxic to a human body, does not generate anaphylactic reaction, thoroughly improves the comfort degree of the lipstick in use, prolongs the coloring time, completely meets the natural and healthy beauty idea of vast females, and is suitable for the vast females and pregnant women to use in daily life.
It should be noted that the above-mentioned embodiments do not limit the present invention in any way, and all technical solutions obtained by using equivalent alternatives or equivalent variations fall within the protection scope of the present invention.
Claims (10)
1. The active oil-soluble anthocyanin is characterized by being prepared by cross-linking and embedding 100-300 parts by weight of functional components, 50-150 parts by weight of oil phase components, 40-100 parts by weight of emulsifying components and 10-30 parts by weight of active components, wherein:
the functional component is anthocyanin;
the oil phase component is one or more of cannabis oil, rose essential oil and camellia oil;
the emulsifying component is one or more of methyl glucose sesquistearate, fatty acid sucrose polyester and coco glucoside;
the active component is edible fungus extract.
2. The active oil-soluble anthocyanin according to claim 1, wherein the edible fungus extract comprises: tremella extract, needle mushroom extract and bolete extract.
3. The method for preparing the active oil-soluble anthocyanin of claim 1, wherein the method comprises the following steps:
(1) heating and melting the emulsified components to obtain an emulsion, and keeping the temperature for later use;
(2) uniformly mixing the functional component and the active component, adding the oil phase component, stirring, homogenizing, and performing crosslinking embedding to obtain a crosslinked substance;
(3) and uniformly mixing the cross-linked product and the emulsion at the same temperature, homogenizing and cooling to obtain the active oil-soluble anthocyanin.
4. The method according to claim 3, wherein the holding temperature in the step (1) is 45 to 60 ℃.
5. The production method according to claim 3, wherein in the step (2), the conditions for the cross-linking embedding are: ultrasonic treatment at 40-50 deg.C for 10min, magnetic stirring for 30min, and homogenizing at 30MPa for 1 time.
6. The method according to claim 3, wherein in the step (3), the mixing temperature is 45 to 50 ℃, the homogenization condition is 30MPa and the homogenization is performed for 2 times, and the cooling temperature is 5 to 10 ℃.
7. Use of the active oil-soluble anthocyanin of claim 1 in beauty cosmetics, dairy products and functional foods.
8. The use according to claim 7, wherein the preparation of the active oil-soluble anthocyanin lipstick/lip balm comprises the following steps:
(1) uniformly mixing 100-200 parts by weight of olive oil, 80-120 parts by weight of sunflower seed oil, 70-100 parts by weight of white Potentilla chinensis seed oil, 50-100 parts by weight of ginger oil and 10-20 parts by weight of aloe oil to obtain a suspension A, heating and raising the temperature, and keeping the temperature for later use;
(2) mixing 40-60 parts by weight of white beeswax, 50-80 parts by weight of yellow beeswax and 20-50 parts by weight of candelilla wax, heating until the mixture is melted to obtain a suspension B, and keeping the temperature for later use;
(3) mixing the suspension A and the suspension B at the same temperature to obtain a suspension C;
(4) adding 10-50 parts by weight of the active oil-soluble anthocyanin as defined in claim 1, 5-20 parts by weight of natural bioactive antibacterial peptide, 5-10 parts by weight of vitamin D and 20-50 parts by weight of orange honey into the suspension C, homogenizing under high pressure, and degassing in a vacuum drying oven under reduced pressure to obtain a mixture;
(5) and (4) quickly pouring the mixture obtained in the step (4) into a lipstick mould and cooling, and demoulding to obtain the active oil-soluble anthocyanin lipstick, or quickly pouring the mixture into a lipstick tank and cooling to obtain the active oil-soluble anthocyanin lipstick.
9. The use according to claim 8, wherein the holding temperature in step (1) and step (2) is 45-60 ℃.
10. The use according to claim 8, wherein in step (4), the high pressure homogenization is performed under 30MPa for 2 times.
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