CN114470067B - Traditional Chinese medicine compound for treating phlebitis and preparation method and application thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine compound for treating phlebitis and its preparation method and application, belonging to the technical field of traditional Chinese medicine. The traditional Chinese medicine compound is composed of the following raw materials in parts by weight: 100-150 parts of potatoes, 3-10 parts of rhubarb, and 10 parts of rhubarb ～20 parts, borneol 1～5 parts. The traditional Chinese medicine compound for treating phlebitis of the present invention has the effects of "reducing swelling and alleviating pain, clearing heat and detoxification, removing blood stasis and stimulating menstruation". Compared with traditional methods, the Chinese medicine compound of the present invention has an effective rate of up to 100% in the treatment of chemotherapy and/or mechanical phlebitis, quick results, no adverse reactions, good patient compliance, and low price, and can effectively prevent and treat phlebitis with It can treat chemotherapeutic and/or mechanical phlebitis, and the preparation of the invention is simple and easy to obtain.

Description

A kind of traditional Chinese medicine compound prescription for treating phlebitis and its preparation method and application

technical field

The invention relates to the technical field of traditional Chinese medicines, in particular to a compound traditional Chinese medicine for treating phlebitis and its preparation method and application.

Background technique

Phlebitis refers to acute aseptic inflammation of venous blood vessels, which is a common clinical disease and frequently-occurring disease. Drug chemotherapy is an important method of cancer treatment, mainly administered intravenously, but chemotherapy drugs often have strong irritation and side effects, and long-term administration can easily cause drug-induced damage to blood vessels, leading to chemotherapy-induced phlebitis. According to statistics, indwelling needles account for more than 90% of intravenous infusion tools in my country, and phlebitis is the most common complication related to indwelling needles. Because many patients need large doses of intravenous infusion for a long time, coupled with factors such as increased vascular fragility and long retention time of indwelling needles, mechanical phlebitis may occur, and the incidence rate is 2.5% to 45%. After patients with varying degrees of phlebitis, cord-like red lines appear along the superficial veins, redness, swelling, pain, burning and induration in local tissues, and even vascular sclerosis and occlusion and local tissue necrosis, which directly lead to difficulty in drug infusion, which is very unfavorable for treatment At the same time, it will increase the risk of thrombosis and increase the physical and psychological pain of patients.

In recent years, phlebitis has gradually received widespread attention, but there is still a certain lag in treatment and nursing methods. Common treatment methods in clinical practice include magnesium sulfate wet compress, external application of ointment boiled from Chinese herbal medicine pieces, potato slices, etc. External therapy such as ointment, hot compress bag/package, paste, spray or gauze soaked medicine wet compress, etc., but the therapeutic effect of the drug It cannot be effectively guaranteed, and there are also problems such as inconvenient operation, frequent dressing changes, easy to contaminate clothes, no unified standard, high price, low technical content, poor body sensation, etc., and some of the above treatment methods also need some infrared radiation and physical therapy. The specific instruments needed are cumbersome to operate, inconvenient to carry, and seriously affect the normal activities and lives of patients.

The theory of traditional Chinese medicine believes that phlebitis is a blood circulation disorder caused by repeated punctures, drug stimulation, etc., and in the state of blood stasis, vascular congestion, etc., heat will accumulate, causing blood overflow in the skin tissue, and local redness can be seen with the naked eye. However, after the treatment of traditional Chinese medicine, it often takes effect slowly and the operation is complicated. At present, there is no Chinese medicine compound that is safe and effective, easy to carry, easy to operate, and quick to take effect.

Contents of the invention

The object of the present invention is to provide a Chinese medicine compound for treating phlebitis and its preparation method and application. Sexual phlebitis has good preventive and therapeutic effects.

In order to achieve the above-mentioned purpose of the invention, the present invention provides the following technical solutions:

The invention provides a traditional Chinese medicine compound prescription for treating phlebitis, which consists of the following raw materials in parts by weight: 100-150 parts of potatoes, 3-10 parts of berberine, 10-20 parts of rhubarb and 1-5 parts of borneol.

Preferably, the traditional Chinese medicine compound recipe is composed of the following raw materials in parts by weight: 110-140 parts of potatoes, 4-9 parts of berberine, 13-18 parts of rhubarb, and 2-4.5 parts of borneol.

The present invention also provides a preparation method of any one of the above-mentioned Chinese medicine compounds, comprising the following steps:

Pulverize potatoes, rhubarb and rhubarb respectively, mix with water and extract to obtain potato extract, rhubarb extract or rhubarb extract;

Crush the borneol, mix it with absolute ethanol, filter and take the filtrate, and obtain the borneol solution;

After mixing the potato extract, the rhubarb extract, the rhubarb extract and the borneol dissolving solution, the traditional Chinese medicine compound is obtained.

Preferably, the preparation of the potato extract comprises the following steps:

The potatoes are crushed and mixed with water, the mass volume ratio of the potatoes and water is 1:5-7, and extracted at 90-100° C. for 25-35 minutes, 1-3 times.

Preferably, the preparation of the Coptidis Rhizome extract comprises the following steps:

Coptidis rhizome is crushed and mixed with water, the mass volume ratio of the rhizome to water is 1:8-12, extracted at 90-100° C. for 45-75 min, 1-3 times.

Preferably, the preparation of the rhubarb extract comprises the following steps:

The rhubarb is pulverized and mixed with water, the mass volume ratio of the rhubarb to water is 1:9-11, extracted at 90-100° C. for 50-70 min, and extracted 1-3 times.

Preferably, the mass volume ratio of the borneol to absolute ethanol is 1:7-13.

The present invention also provides the application of any one of the above-mentioned traditional Chinese medicine compounds in the preparation of medicines for treating phlebitis.

Preferably, said phlebitis comprises chemotherapy phlebitis and/or mechanical phlebitis.

Compared with the prior art, the present invention has the following beneficial effects:

The traditional Chinese medicine compound for treating phlebitis has the effects of "reducing swelling and relieving pain, clearing away heat and detoxification, removing blood stasis and stimulating menstrual flow". Compared with traditional methods, the Chinese medicine compound of the present invention has an effective rate of up to 100% for the treatment of chemotherapeutic phlebitis and mechanical phlebitis, quick results, no adverse reactions, good patient compliance, low price, and can effectively prevent and treat phlebitis with It can treat chemotherapeutic phlebitis and mechanical phlebitis, and the preparation of the invention is simple and easy to obtain. The invention not only solves the problems of high treatment cost, large adverse reactions, inconvenient use, and poor compliance of traditional external application of medicines, but also solves the problems that some treatments require specific instruments such as infrared irradiation and physiotherapy, and cumbersome operating steps.

Description of drawings

Fig. 1 is a comparison diagram of the treatment situation before and after applying the traditional Chinese medicine compound hydrogel of Example 1, wherein the block diagram is the application site.

Detailed ways

The invention provides a traditional Chinese medicine compound prescription for treating phlebitis, which consists of the following raw materials in parts by weight: 100-150 parts of potatoes, 3-10 parts of berberine, 10-20 parts of rhubarb and 1-5 parts of borneol.

In the present invention, the traditional Chinese medicine compound is preferably composed of the following raw materials in parts by weight: 110-140 parts of potatoes, 4-9 parts of berberine, 13-18 parts of rhubarb, and 2-4.5 parts of borneol.

In the present invention, potato is the king drug, detoxifying, reducing swelling and relieving pain; Coptis chinensis is heat-clearing and detoxifying, rhubarb cooling blood is detoxifying, removing blood stasis and dredging menstrual flow is a ministerial drug altogether; , the effect of removing blood stasis and promoting menstruation. The traditional Chinese medicine compound prescription of the present invention is improved on the basis of external application of potato slices commonly used by folks to reduce swelling and relieve pain. After repeated clinical verification, the effective rate of treating mechanical and chemotherapeutic phlebitis is as high as 100%. The present invention does not limit the sources of potatoes, rhubarb, borneol, and commercially available products known in the art can be used.

The present invention provides the preparation method of above-mentioned any one Chinese medicine compound, comprises the following steps:

Pulverize potatoes, rhubarb and rhubarb respectively, mix with water and extract to obtain potato extract, rhubarb extract or rhubarb extract;

Crush the borneol, mix it with absolute ethanol, filter and take the filtrate, and obtain the borneol solution;

After mixing the potato extract, the rhubarb extract, the rhubarb extract and the borneol dissolving solution, the traditional Chinese medicine compound is obtained.

In the present invention, the preparation of the potato extract preferably includes the following steps: crush the potato and mix it with water, the mass volume ratio of the potato to water is 1:5-7, extract at 90-100°C for 25- 35min, extracting 1-3 times; the preparation of the potato extract more preferably includes the following steps: crushing the potato and mixing with water, the mass volume ratio of the potato and water is 1:6, extracting at 100°C for 30min, Extract 2 times.

The preparation of the Coptis chinensis extract preferably includes the following steps: crush the Coptis chinensis and mix it with water, the mass volume ratio of the Coptis chinensis and water is 1:8-12, extract at 90-100° C. for 45-75 minutes, and extract for 1-20 minutes. 3 times. The preparation of the Coptis chinensis extract more preferably includes the following steps: crushing the Coptis chinensis and mixing it with water, the mass volume ratio of the Coptis chinensis and water is 1:10, extracting at 100° C. for 60 min, twice.

The preparation of the rhubarb extract preferably includes the following steps: crush the rhubarb and mix it with water, the mass volume ratio of the rhubarb to water is 1:9-11, extract at 90-100°C for 50-70min, extract for 1- 3 times. The preparation of the rhubarb extract more preferably includes the following steps: crush the rhubarb and mix it with water, the mass volume ratio of the rhubarb to water is 1:10, extract at 100°C for 60 min, and extract twice.

The mass volume ratio of the borneol to absolute ethanol is preferably 1:7-13, more preferably 1:10.

The potato extract, coptis extract and rhubarb extract prepared above also include concentration and filtration, the concentration is preferably concentrated to 1/10 under reduced pressure at 65°C, and the filtration is preferably 0.22 μm ceramic membrane filtration . The invention extracts the potato, rhubarb and coptis separately and then mixes them, which can effectively prevent the reaction between the components when the potato and other traditional Chinese medicine raw materials are mixed and extracted so that the pharmacological activity is lost.

The present invention also provides the application of any one of the above-mentioned traditional Chinese medicine compounds in the preparation of medicines for treating phlebitis.

In the present invention, the medicine includes Chinese medicine compound as an active ingredient and a pharmaceutically acceptable carrier, and the medicine can be made into hydrogel, water curd, plaster, spray, ointment, cream, Paste, coating, the medicine is applied externally. Wherein the preparation method of Chinese medicine compound hydrogel is as follows:

Preparation Phase 1: Aluminum Glycol 0.14%, NOVETAC P55N 0.5%, EDTA 0.12%, NOVETAC P46N 5%, Glycerin 25%;

Preparation phase 2: tartaric acid 0.22%, DMDMH 0.2%, purified water 50%;

Preparation phase 3: 0.45% alcohol, 0.25% menthol;

Preparation phase 4: the remaining amount of the compound Chinese medicine of the present invention.

Mix the preparation phase 2 and the preparation phase 4 evenly, then add the preparation phase 1, stir evenly, then add the preparation phase 3, stir quickly to form a colloid, and enter the coating machine to make a hydrogel paste for later use.

In the present invention, unless otherwise specified, all raw material components are commercially available products well known to those skilled in the art.

The technical solutions in the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

Example 1

A compound traditional Chinese medicine for treating phlebitis, which consists of the following raw materials in parts by weight: 100g of potatoes, 10g of berberine, 15g of rhubarb and 1g of borneol.

The preparation method of described Chinese medicine compound, concrete steps are as follows:

Crush the above potatoes and mix with 600mL of water, extract at 100°C for 30min, filter to obtain the extract and potato residue, then repeat the extraction of the potato residue once according to the above operation, combine the extract, and then concentrate the extract under reduced pressure at 65°C To 1/10, filter the filtrate through a 0.22μm ceramic membrane to obtain the potato extract;

Crush the Coptidis rhizome above and mix it with 100mL of water, extract at 100°C for 60min, filter to obtain the extract and Coptis chinensis residue, then repeat the extraction of the Coptis chinensis residue once according to the above operation, combine the extracts, and then concentrate the extract under reduced pressure at 65°C To 1/10, filter through a 0.22μm ceramic membrane to get the filtrate to obtain the Coptidis Rhizome extract;

Grind the above rhubarb and mix it with 150mL of water, extract at 100°C for 60min, filter to obtain the extract and rhubarb residue, then repeat the extraction of the rhubarb residue once according to the above operation, combine the extract, and then concentrate the extract under reduced pressure at 65°C To 1/10, filter the filtrate through a 0.22μm ceramic membrane to obtain the rhubarb extract;

Crush the above-mentioned borneol, mix and dissolve it with 10 mL of absolute ethanol, filter through a 0.22 μm ceramic membrane to obtain the filtrate, and obtain the borneol solution;

After mixing the potato extract, rhubarb extract, rhubarb extract and borneol dissolving solution, the traditional Chinese medicine compound is obtained.

Example 2

A compound traditional Chinese medicine for treating phlebitis, which consists of the following raw materials in parts by weight: 120g of potatoes, 5g of berberine, 10g of rhubarb and 3g of borneol.

The preparation method of described Chinese medicine compound, concrete steps are as follows:

Crush the above-mentioned potatoes and mix them with 600mL of water, extract at 95°C for 25 minutes, filter to obtain the extract and potato residue, then repeat the extraction of the potato residue twice according to the above operation, combine the extracts, and then concentrate the extracts under reduced pressure at 65°C To 1/10, filter the filtrate through a 0.22μm ceramic membrane to obtain the potato extract;

Crush the Coptidis rhizome above and mix it with 40mL of water, extract at 95°C for 45min, filter to obtain the extract and Coptis chinensis residue, then repeat the extraction of the Coptis chinensis residue twice according to the above operation, combine the extracts, and then concentrate the extract under reduced pressure at 65°C To 1/10, filter through a 0.22μm ceramic membrane to get the filtrate to obtain the Coptidis Rhizome extract;

Grind the above rhubarb and mix it with 90mL of water, extract at 95°C for 50min, filter to obtain the extract and rhubarb residue, then repeat the extraction of the rhubarb residue once according to the above operation, combine the extract, and then concentrate the extract under reduced pressure at 65°C To 1/10, filter the filtrate through a 0.22μm ceramic membrane to obtain the rhubarb extract;

Crush the borneol, mix and dissolve it with 21mL of absolute ethanol, filter the filtrate through a 0.22μm ceramic membrane, and obtain the borneol solution;

After mixing the potato extract, rhubarb extract, rhubarb extract and borneol dissolving solution, the traditional Chinese medicine compound is obtained.

Example 3

A compound traditional Chinese medicine for treating phlebitis, which consists of the following raw materials in parts by weight: 150g of potatoes, 3g of berberine, 20g of rhubarb and 5g of borneol.

The preparation method of described Chinese medicine compound, concrete steps are as follows:

Crush the above potatoes and mix them with 1050mL of water, extract at 90°C for 35min, filter to obtain the extract, then concentrate the extract to 1/10 under reduced pressure at 65°C, and filter through a 0.22μm ceramic membrane to obtain the potato extract ;

Crush the above Coptis rhizome and mix it with 36mL of water, extract at 90°C for 45min, filter to obtain the extract, then concentrate the extract to 1/10 under reduced pressure at 65°C, filter through a 0.22μm ceramic membrane to get the filtrate, and obtain the Coptis chinensis extract ;

Grind the rhubarb above and mix with 220mL of water, extract at 90°C for 70min, filter to obtain the extract, then concentrate the extract to 1/10 under reduced pressure at 65°C, filter the filtrate through a 0.22μm ceramic membrane, and obtain the rhubarb extract ;

Crush the borneol, mix it with 65 mL of absolute ethanol, filter through a 0.22 μm ceramic membrane to get the filtrate, and obtain the borneol solution;

After mixing the potato extract, rhubarb extract, rhubarb extract and borneol dissolving solution, the traditional Chinese medicine compound is obtained.

Example 4

A preparation method of Chinese medicine compound hydrogel is as follows:

Preparation Phase 1: Aluminum Glycol 0.14%, NOVETAC P55N 0.5%, EDTA 0.12%, NOVETAC P46N 5%, Glycerin 25%;

Preparation phase 2: tartaric acid 0.22%, DMDMH 0.2%, purified water 50%;

Preparation phase 3: 0.45% alcohol, 0.25% menthol;

Preparation phase 4: the balance of the traditional Chinese medicine compound prepared in Example 1.

Mix the preparation phase 2 and the preparation phase 4 evenly, then add the preparation phase 1, stir evenly, then add the preparation phase 3, stir quickly to form a colloid, and enter the coating machine to make a hydrogel paste for later use.

Usage: When the patient's symptoms appear, apply it once for 3 hours.

Example 5

A preparation method of Chinese medicine compound hydrogel is as follows:

Preparation Phase 1: Aluminum Glycol 0.14%, NOVETAC P55N 0.5%, EDTA 0.12%, NOVETAC P46N 5%, Glycerin 25%;

Preparation phase 2: tartaric acid 0.22%, DMDMH 0.2%, purified water 50%;

Preparation phase 3: 0.45% alcohol, 0.25% menthol;

Preparation phase 4: the balance of the traditional Chinese medicine compound prepared in Example 2.

Mix the preparation phase 2 and the preparation phase 4 evenly, then add the preparation phase 1, stir evenly, then add the preparation phase 3, stir quickly to form a colloid, and enter the coating machine to make a hydrogel paste for later use.

Usage: When the patient's symptoms appear, apply it once for 3 hours.

Example 6

A preparation method of Chinese medicine compound hydrogel is as follows:

Preparation Phase 1: Aluminum Glycol 0.14%, NOVETAC P55N 0.5%, EDTA 0.12%, NOVETAC P46N 5%, Glycerin 25%;

Preparation phase 2: tartaric acid 0.22%, DMDMH 0.2%, purified water 50%;

Preparation phase 3: 0.45% alcohol, 0.25% menthol;

Preparation phase 4: the balance of the traditional Chinese medicine compound prepared in Example 3.

Mix the preparation phase 2 and the preparation phase 4 evenly, then add the preparation phase 1, stir evenly, then add the preparation phase 3, stir quickly to form a colloid, and enter the coating machine to make a hydrogel paste for later use.

Usage: When the patient's symptoms appear, apply it once for 3 hours.

Comparative example 1

The difference between this comparative example and Example 4 is that the hydrogel of this comparative example replaces the Chinese medicine compound described in Example 4 with an equal-quality potato extract, and the preparation method of the potato extract is the same as in Example 1. In the preparation method of the hydrogel, the traditional Chinese medicine compound is replaced by the potato extract, and other steps are the same.

Usage: When the patient's symptoms appear, apply it once for 3 hours.

Comparative example 2

The difference between this comparative example and Example 5 is that the hydrogel of this comparative example replaces the Chinese medicine compound in Example 5 with rhubarb extract and Coptis chinensis extract, wherein the total mass of rhubarb extract and Coptis chinensis extract is the same as that of the Chinese medicine compound Same, the mass ratio of rhubarb extract and coptis extract is 3:2. The preparation method of rhubarb extract and coptis extract is the same as that of Example 1. In the preparation method of the hydrogel, the traditional Chinese medicine compound is replaced by rhubarb extract and coptis extract, and other steps are the same.

Usage: When the patient's symptoms appear, apply it once for 3 hours.

Comparative example 3

This comparative example is fresh potato slices: choose fresh potatoes, wash them with clear water, peel them, and slice the potatoes with a thickness of 0.5 cm per slice.

Stick it on the skin according to the size of the phlebitis, and the sticking area is slightly larger than the skin area of the phlebitis. Wrap the affected limb with a plastic wrap in a circular shape, the tightness is appropriate, not too tight, so as not to cause blood supply to the local skin.

Usage: Immediately apply 6 times when the patient's symptoms appear, 1 time for 1 hour.

Comparative example 4

This comparative example adopts 50% magnesium sulfate solution, cleans the patient's skin with warm water and covers the affected part with three layers of gauze before the operation, adopts 50% magnesium sulfate solution to soak the gauze, it is advisable not to drip, and wraps the gauze with plastic wrap at the same time, Make the magnesium sulfate solution not easy to evaporate.

Use: Immediately wet compress 2 times when the patient's symptoms appear, 1 time for 3 hours.

Test example 1

Patients with chemotherapeutic and mechanical phlebitis were selected for drug activity test. The diagnosis and evaluation methods are as follows:

1. Clinical patient data

Select chemotherapy and mechanical phlebitis in 111 patients, aged 35 to 78 years, with an average age of (52 ± 10.1) years. Diseases involved include: liver cancer, gastric cancer, pancreatic cancer, gallbladder cancer, colon cancer, liver cirrhosis, gastrointestinal bleeding, pancreatitis, cholecystitis, coronary heart disease, diabetes. The drugs used include: chemotherapy drugs such as cyclophosphamide and paclitaxel, antibiotics such as etimicin sulfate, cefoperazone and sulbactam sodium, and fluid replacement therapy.

2. Using the random number table method, 6 cases in the blank group, and 15 cases in each other group, the random grouping and treatment methods are as follows:

Blank group: no treatment.

Embodiment 4: Apply once for 3 hours.

Embodiment 5: Apply once for 3 hours.

Embodiment 6: Apply once for 3 hours.

Comparative example 1: Apply once for 3 hours.

Comparative example 2: Apply once for 3 hours.

Comparative example 3: apply 6 times, 1 hour per time.

Comparative example 4: Wet compress 2 times, 3 hours each time.

3. Evaluation indicators

(1) VAS Scoring Criteria

The visual analog scale method is used: a 100mm long scale is marked with "no pain" at one end and "severe pain" at the other end, and the patient marks the corresponding position according to the intensity of pain. In clinical evaluation, "0-2" indicates "excellent", "3-5" indicates "good", "6-8" indicates "fair", and >"8" indicates "poor".

(2) Average pain subside time

The average time from external application to the complete disappearance of pain.

(3) Average time for redness and swelling to subside

The average time from external application of the plexus to the complete disappearance of redness and swelling.

(4) Evaluating Criteria for Efficacy

Healed: clinical symptoms disappeared, the veins in the affected area softened and the elasticity of blood vessels recovered after the intervention, and there was no tenderness, redness and swelling in the affected limbs and affected areas; markedly effective: the blood vessels in the affected area became soft after the intervention, with slight tenderness and redness; effective: the blood vessels in the affected area were softer after the intervention The anterior part becomes softer, the redness and pain are slightly reduced or unchanged, and the blood vessels of the patient are still in the shape of cords; invalid: the blood vessels of the affected part remain unchanged or aggravated after the intervention, and the degree of pain remains unchanged or aggravated. Total effective rate=(number of cured cases+number of effective cases+number of markedly effective cases)/total number of cases×100%.

4. Results

According to the above diagnosis and evaluation criteria, the hydrogels described in the above-mentioned Examples 1-3, Comparative Examples 1-2, the fresh potato slices of Comparative Example 3, and the 50% magnesium sulfate solution of Comparative Example 4 are used for the treatment of chemotherapeutic and mechanical Patients with chronic phlebitis, without any treatment as blank group, the results are shown in Table 1, Table 2 and Table 3, and the treatment situation before and after applying the Chinese medicine compound hydrogel of Example 1 is shown in Figure 1.

Table 1 The average pain degree, the average pain subsidence time and the average redness subsidence time

The results in Table 1 show that, compared with the comparative example, after treating phlebitis by using the Chinese medicine compound hydrogel of Examples 1 to 3 of the present invention, the pain degree of the patient is significantly reduced, and the average pain subsides time, and the average redness subsides. The time is significantly shortened, the patient feels better after using it, the pain is relieved obviously, it is clean, easy to operate, and has no adverse reactions.

Table 2 Evaluation of curative effect (with 3h curative effect as the observation time point)

It can be known from Table 2 that compared with the comparative example, the effective rate of the Chinese medicine compound of the present invention is as high as 100%.

Table 3 Adverse reactions

As can be seen from Table 3, the Chinese medicine compound of the present invention has no adverse reaction when treating phlebitis, and has high safety.

It can be seen from the results in Fig. 1 that redness, swelling and pain appeared at the venipuncture site before application, and the Chinese medicine compound hydrogel of Example 1 of the present invention was applied once for a total of 3 hours. After 24 hours of observation, the redness and pain disappeared.

During the course of treatment, the traditional Chinese medicine compound hydrogels of Examples 1-3 all had good curative effects, and achieved the effect of reducing swelling and relieving pain within 3 hours, while Comparative Examples 1-2 had a slight curative effect, but the curative effect was far lower than that of Example 1. ~3 traditional Chinese medicine compound hydrogels. In comparative example 4, magnesium sulfate needs to be wrapped with plastic wrap, which seriously affects the patient's activities and quality of life. The patient's compliance is poor, and there is a certain degree of skin irritation. There are 3 patients with skin itching, and 2 patients with aggravated pain. The potato slices in 3 need to be wrapped and fixed with plastic wrap, and the frequency of replacing potato slices is high, which also seriously affects the activities and quality of life of the patients, and the compliance is poor, and 2 patients developed itching.

In conclusion, the traditional Chinese medicine compound for treating phlebitis of the present invention, compared with potato slices and magnesium sulfate wet compress, has a very significant effect of relieving pain and detumescence, has no adverse reactions, and has good patient compliance, and has a more convenient It has the advantages of convenient operation, less frequency of dressing change, long action time, not easy to contaminate clothes, low price, good body feeling, etc. The present invention makes use of the synergistic effect between the raw materials to effectively Prevention and treatment of phlebitis.

Typical Case

Wang, male, 52 years old, is from Changchun, Jilin Province. Redness, swelling, heat, and pain appear at the puncture site after intravenous infusion. After using the Chinese medicine compound hydrogel paste of the present invention for 1 hour, the local redness, swelling, heat and pain at the puncture site disappeared.

Liu, female, 33 years old, was born in Shenyang, Liaoning Province. More than 10 days after the intravenous infusion, the puncture point was red, swollen, hot, and painful. After using the Chinese medicine compound hydrogel paste of the present invention for 2 hours, the local redness, swelling, heat and pain at the puncture site disappeared.

Yan, female, 65 years old, was born in Dunhua, Jilin Province. After more than 20 days of intravenous infusion, the puncture point was red, swollen, hot, and painful. After using the traditional Chinese medicine compound hydrogel paste of the present invention for 1 hour, the local redness, swelling, heat and pain at the puncture site disappeared.

The above is only a preferred embodiment of the present invention, it should be pointed out that, for those of ordinary skill in the art, without departing from the principle of the present invention, some improvements and modifications can also be made, and these improvements and modifications can also be made. It should be regarded as the protection scope of the present invention.

Claims (6)

1. The traditional Chinese medicine composition for treating phlebitis is characterized by being prepared from the following raw materials in parts by weight: 100-150 parts of potato, 3-10 parts of coptis chinensis, 10-20 parts of rheum officinale and 1-5 parts of borneol;

the preparation method of the traditional Chinese medicine composition comprises the following steps:

pulverizing rhizoma Solani Tuber osi, coptidis rhizoma and radix et rhizoma Rhei respectively, mixing with water, and extracting to obtain rhizoma Solani Tuber osi extract, coptidis rhizoma extract or radix et rhizoma Rhei extract;

pulverizing Borneolum Syntheticum, mixing with absolute ethanol, and filtering to obtain Borneolum Syntheticum solution;

mixing rhizoma Solani Tuber osi extract, coptidis rhizoma extract, radix et rhizoma Rhei extract and Borneolum Syntheticum solution to obtain Chinese medicinal composition;

the preparation of the coptis extract comprises the following steps:

pulverizing coptis chinensis, and mixing with water, wherein the mass volume ratio of the coptis chinensis to the water is 1: 8-12, extracting for 45-75 min at 90-100 ℃ for 1-3 times;

the preparation of the rheum officinale extract comprises the following steps:

crushing rheum officinale, and mixing the crushed rheum officinale with water, wherein the mass volume ratio of the rheum officinale to the water is 1:9 to 11, extracting for 50 to 70 minutes at the temperature of between 90 and 100 ℃ for 1 to 3 times;

the preparation of the potato extract comprises the following steps:

crushing potatoes, mixing the crushed potatoes with water, extracting the potatoes and the water for 25 to 35 minutes at a temperature of between 90 and 100 ℃ for 1 to 3 times, wherein the mass volume ratio of the potatoes to the water is 1:5 to 7;

the potato extract, the coptis extract and the rheum officinale extract also comprise concentrating and filtering to obtain filtrate, and then the potato extract, the coptis extract or the rheum officinale extract is obtained.

2. The traditional Chinese medicine composition according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 110-140 parts of potato, 4-9 parts of coptis chinensis, 13-18 parts of rheum officinale and 2-4.5 parts of borneol.

3. The method for preparing the traditional Chinese medicine composition according to claim 1 or 2, comprising the following steps:

pulverizing rhizoma Solani Tuber osi, coptidis rhizoma and radix et rhizoma Rhei respectively, mixing with water, and extracting to obtain rhizoma Solani Tuber osi extract, coptidis rhizoma extract or radix et rhizoma Rhei extract;

pulverizing Borneolum Syntheticum, mixing with absolute ethanol, and filtering to obtain Borneolum Syntheticum solution;

mixing rhizoma Solani Tuber osi extract, coptidis rhizoma extract, radix et rhizoma Rhei extract and Borneolum Syntheticum solution to obtain Chinese medicinal composition;

the preparation of the potato extract comprises the following steps:

crushing potatoes, mixing the crushed potatoes with water, extracting the potatoes and the water for 25 to 35 minutes at a temperature of between 90 and 100 ℃ for 1 to 3 times, wherein the mass volume ratio of the potatoes to the water is 1:5 to 7;

the preparation of the coptis extract comprises the following steps:

pulverizing coptis chinensis, and mixing with water, wherein the mass volume ratio of the coptis chinensis to the water is 1: 8-12, extracting for 45-75 min at 90-100 ℃ for 1-3 times;

the preparation of the rheum officinale extract comprises the following steps:

crushing rheum officinale, and mixing the crushed rheum officinale with water, wherein the mass volume ratio of the rheum officinale to the water is 1:9 to 11, extracting for 50 to 70 minutes at the temperature of between 90 and 100 ℃ for 1 to 3 times;

the potato extract, the coptis extract and the rheum officinale extract also comprise concentrating and filtering to obtain filtrate, and then the potato extract, the coptis extract or the rheum officinale extract is obtained.

4. The preparation method according to claim 3, wherein the mass-volume ratio of the borneol to the absolute ethyl alcohol is 1:7-13.

5. Use of the traditional Chinese medicine composition according to claim 1 or 2 in the preparation of a medicament for treating phlebitis.

6. The use according to claim 5, wherein the phlebitis comprises chemotherapeutic phlebitis and mechanical phlebitis.

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