CN114468344B - Electronic cigarette liquid containing nicotine salt - Google Patents
Electronic cigarette liquid containing nicotine salt Download PDFInfo
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- CN114468344B CN114468344B CN202011262568.2A CN202011262568A CN114468344B CN 114468344 B CN114468344 B CN 114468344B CN 202011262568 A CN202011262568 A CN 202011262568A CN 114468344 B CN114468344 B CN 114468344B
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- nicotine
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an electronic cigarette liquid containing nicotine salt, which comprises nicotine salt, a fragrance-generating component, water and an atomizing component, wherein the nicotine salt comprises phosphoric acid nicotine salt and also comprises one or a mixture of more of tartaric acid nicotine salt, malic acid nicotine salt, oxalic acid nicotine salt and benzoic acid nicotine salt. According to the invention, the phosphoric acid nicotine salt is added into the nicotine salt, and the content of free nicotine in the smoke aerosol is reduced by combining the phosphoric acid nicotine salt with different nicotine salts, so that the irritation of nicotine in the electronic cigarette liquid can be effectively reduced, the taste of the electronic cigarette liquid is improved, and the atomization amount and the uniformity of smoke release are improved.
Description
Technical Field
The invention relates to the technical field of novel tobacco products, in particular to electronic cigarette liquid containing nicotine salt.
Background
In recent years, electronic cigarettes containing the nicotine salt are touted by consumers, and compared with free nicotine, the electronic cigarette liquid added with the nicotine salt can remarkably improve the sensory quality and reduce the choking throat feeling. The existing electronic cigarette liquid comprises nicotine salt, aroma components and atomization components, wherein the atomization components generally adopt propylene glycol and/or glycerol. It has been reported that when nicotine salts are used to formulate electronic cigarette solutions, the time required for the volunteers to reach maximum nicotine content in the blood after smoking electronic cigarettes and the rate of heart rate rise are comparable to or even better than those of conventional cigarettes. Pax Labs in 2015 reacted with nicotine using benzoic acid as an additive to produce nicotine benzoate, which resulted in consumer smoothness during consumption. David et al show that in the electronic cigarette suction process, aerosol particle size generated by the electronic cigarette containing the nicotine salt is more suitable for delivery to the lung, so that the irritation of the aerosol to the throat can be reduced, and the satisfaction is enhanced. The electronic cigarette liquid containing the nicotine salt not only can solve the defects of bad smell, large stimulus and miscellaneous gas caused by free nicotine in aerosol and poor sensory experience, but also can increase the stability of nicotine in the electronic cigarette liquid placing process.
The thermal stability and the release temperature of different nicotine salts are different to a certain extent, and the thermal stability of the nicotine salts is as follows from low to high: liquid nicotine salts (nicotine acetate), crystalline nicotine salts (e.g. nicotine gallate), unoriented solid nicotine salts (e.g. nicotine alginate). The release temperature varies from 83-300 ℃ according to different nicotine salts and different sample amounts. The heating and atomizing temperature of the electronic cigarette appliance is approximately in the range of 150-250 ℃, and early researches show that the electronic cigarette liquid containing the nicotine salt exists in the smoke aerosol after being sucked in the electronic cigarette appliance in the combination of free nicotine and nicotine salt in different proportions. Different nicotine salts have a large difference in the degree of decomposition of the nicotine salts in the aerosol.
Although the nicotine salt added into the electronic cigarette liquid can reduce the throat choking sensation, the nicotine salt which is currently applied to the electronic cigarette liquid still has obvious throat choking sensation in the sucking process, the atomization amount is not released stably, the atomization amount is mainly concentrated in 0-30 mouths to be released, and the atomization amount of 30-120 mouths is obviously reduced. The tartaric acid nicotine salt also has the problem of choking the throat. Therefore, the electronic cigarette liquid containing the nicotine salt is taken as a research object, the transfer rate conditions of free nicotine and proton nicotine of different nicotine salts in aerosol are thoroughly examined, most of the nicotine salt types in the aerosol exist in the form of the nicotine salt are selected, the free nicotine content in the aerosol is reduced, the problems of reducing the stimulation of smoke and improving the taste of the smoke are achieved, and the quality of electronic cigarette products is improved.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the electronic cigarette liquid containing the nicotine salt, which reduces the content of free nicotine in the aerosol by combining different nicotine salts and improves the atomization amount and the uniformity of released smoke.
In order to solve the technical problems, the invention adopts the following technical scheme:
an electronic cigarette liquid containing nicotine salt, the electronic cigarette liquid comprises nicotine salt, aroma-generating component, water and atomization component, the nicotine salt comprises phosphoric acid nicotine salt, and the electronic cigarette liquid further comprises one or a mixture of more of tartaric acid nicotine salt, malic acid nicotine salt, oxalic acid nicotine salt and benzoic acid nicotine salt.
The nicotine phosphate salt has low release amount of nicotine in aerosol, low mobility, good atomization amount, good uniformity of released smoke, and can effectively reduce the irritation of nicotine in electronic cigarette liquid and improve the uniformity of overall smoke release by combining the nicotine phosphate salt with high mobility.
Further, the nicotine phosphate accounts for 20-80% of the mass of the nicotine salt.
Further, the nicotine phosphate accounts for 30-67% of the mass of the nicotine salt.
Further, the nicotine salt comprises nicotine phosphate salt, and further comprises the nicotine tartrate salt or the nicotine malate salt.
Further, the molar ratio of the acid to the nicotine in the tartaric acid nicotine salt is 1:1 or 2:1, and the molar ratio of the acid to the nicotine in the malic acid nicotine salt is 2:1.
Further, the electronic cigarette liquid comprises the following components in percentage by mass: 2-4% of nicotine salt, 5-8% of aroma-generating component, 9-12% of water and the balance of atomizing component.
Compared with the prior art, the invention has the following beneficial effects: according to the invention, the phosphoric acid nicotine salt is added into the nicotine salt, and the content of free nicotine in the smoke aerosol is reduced by combining the phosphoric acid nicotine salt with different nicotine salts, so that the irritation of nicotine in the electronic cigarette liquid can be effectively reduced, the taste of the electronic cigarette liquid is improved, and the atomization amount and the uniformity of smoke release are improved.
Drawings
FIG. 1 is a graph comparing the effects of salt atomization of different nicotine salts;
FIG. 2 is a graph showing the variation of nicotine release from an aerosol according to example 1 of the present invention;
FIG. 3 is a graph showing the variation of nicotine release from an aerosol of comparative example 1 of the present invention;
FIG. 4 is a graph showing the variation of nicotine release from an aerosol in accordance with example 2 of the present invention;
fig. 5 is a graph showing the variation of nicotine release from an aerosol according to comparative example 2 of the present invention.
Detailed Description
Studies containing different nicotine salts included: the calculation formula of the migration rate of nicotine and nicotine salt in the aerosol of the electronic cigarette liquid of the tartaric acid nicotine salt (the molar ratio of acid to nicotine is 2:1), the tartaric acid nicotine salt (the molar ratio of acid to nicotine is 1:1), the malic acid nicotine salt (the molar ratio of acid to nicotine is 1:1), the phosphoric acid nicotine salt, the oxalic acid nicotine salt (the molar ratio of acid to nicotine is 2:1), the oxalic acid nicotine salt (the molar ratio of acid to nicotine is 1:1) and the benzoic acid nicotine salt is as follows:
wherein, X: indicating the nicotine transfer rate in the aerosol;
m1: represents 0-120 mouthpart aerosol total nicotine content;
m2: representing the nicotine content in the 0-120 mouths of electronic cigarette liquid.
The calculation results are shown in table 1, and the nicotine stimulation in the electronic cigarette liquid is reduced by selecting a nicotine salt formula with better mobility of the nicotine salt in the aerosol, so that the taste of the electronic cigarette is more comfortable.
Table 1 comparison of the mobilities of different nicotine salts in aerosol nicotine
The results show that the mobility of nicotine in aerosol is reduced to a certain extent, and the nicotine content in the aerosol can be effectively reduced by containing the nicotine malate salt (the molar ratio of acid to nicotine is 2:1), the nicotine tartrate salt (the molar ratio of acid to nicotine is 1:1) and the nicotine phosphate salt. In addition, the release amount of nicotine in aerosol of the nicotine malate salt (the molar ratio of acid to nicotine is 2:1), the nicotine tartrate salt (the molar ratio of acid to nicotine is 1:1) and the nicotine phosphate salt are reduced more, the decomposition temperature of the nicotine salts is higher, the nicotine salts are difficult to atomize into the aerosol in the sucking process, the nicotine amount in the aerosol is greatly reduced, and the effect of reducing the irritation of smoke is achieved. The release amount of nicotine in the aerosol of the phosphoric acid nicotine salt is the lowest, and the phosphoric acid nicotine salt can be used in combination with other screened nicotine salts, so that the release amount of nicotine in the aerosol of the nicotine salt is reduced, and the smoke irritation is reduced.
In addition, we also studied the difference of atomization effect of different nicotine salts in the electronic smoke sol, and we measure the atomization effect of different nicotine salts by taking free nicotine as a standard, as shown in figure 1, the atomization effect of oxalic acid nicotine hydrochloride and nicotine is better and more stable, and the atomization effect of oxalic acid nicotine salt (the molar ratio of acid to nicotine is 1:1) and benzoic acid nicotine salt is better.
By combining the comparison of nicotine mobility of different nicotine salts in aerosol and the difference comparison of atomization effects of different nicotine salts in electronic cigarette liquid, one or more of malic acid nicotine salt (molar ratio of acid to nicotine is 1:1), tartaric acid nicotine salt (molar ratio of acid to nicotine is 2:1), tartaric acid nicotine salt (molar ratio of acid to nicotine is 1:1) and phosphoric acid nicotine salt are added into the electronic cigarette liquid to replace free nicotine, so that the atomization amount of the electronic cigarette liquid is effectively ensured, the stimulation of nicotine in the electronic cigarette liquid is effectively reduced, and the taste of the electronic cigarette liquid is improved.
Example 1
The electronic cigarette liquid containing the nicotine salt comprises the following components in percentage by mass: 1% of nicotine tartrate (molar ratio of acid to nicotine is 1:1), 2% of nicotine phosphate, 5% of tobacco essence, 9% of deionized water, 40% of glycerol and 43% of propylene glycol.
When the electronic cigarette liquid is prepared, the components are prepared, then the components are mixed, and the mixture is stirred for 30min at normal temperature to fully mix the components.
1mL of electronic cigarette liquid containing the nicotine salt combination is placed in an electronic cigarette appliance to be smoked by a linear smoking machine, and the nicotine amount and mobility in 120-mouth aerosol are measured. The corresponding amount of nicotine in the electronic cigarette liquid in the 120-mouth aerosol is 6.05mg, the amount of nicotine released in the 120-mouth aerosol is 3.75mg, the mobility of nicotine is 61.92%, and the change of nicotine release in the aerosol during the sucking process is shown in figure 2.
Comparative example 1
The electronic cigarette liquid containing the nicotine salt comprises the following components in percentage by mass: tartaric acid nicotine salt (molar ratio of acid to nicotine is 1:1) 3%, tobacco essence 5%, deionized water 9%, glycerol 40% and propylene glycol 43%.
When the electronic cigarette liquid is prepared, the components are prepared, then the components are mixed, and the mixture is stirred for 30min at normal temperature to fully mix the components. 1mL of electronic cigarette liquid containing the nicotine salt combination is placed in an electronic cigarette appliance to be smoked by a linear smoking machine, and the nicotine amount and mobility in 120-mouth aerosol are measured. The corresponding amount of nicotine in the electronic cigarette liquid in the 120-mouth aerosol is 6.21mg, the released amount of nicotine in the 120-mouth aerosol is 4.69mg, the mobility of nicotine is 75.48%, and the release change of nicotine in the aerosol in the sucking process is shown in figure 3.
Example 2
The electronic cigarette liquid containing the nicotine salt comprises the following components in percentage by mass: 1% of nicotine phosphate, 2% of nicotine malate (the molar ratio of acid to nicotine is 1:1), 5% of tobacco essence, 9% of deionized water, 40% of glycerol and 43% of propylene glycol.
When the electronic cigarette liquid is prepared, the components are prepared, then the components are mixed, and the mixture is stirred for 30min at normal temperature to fully mix the components. 1mL of electronic cigarette liquid containing the nicotine salt combination is placed in an electronic cigarette appliance to be smoked by a linear smoking machine, and the nicotine amount and mobility in 120-mouth aerosol are measured. The corresponding amount of nicotine in the electronic cigarette liquid in the 120-mouth aerosol is 5.85mg, the amount of nicotine released in the 120-mouth aerosol is 4.85mg, the mobility of nicotine is 83.35%, and the nicotine release in the aerosol changes during the sucking process as shown in figure 4.
Comparative example 2
The electronic cigarette liquid containing the nicotine salt comprises the following components in percentage by mass: the cigarette comprises (by mole ratio) nicotine malate (1:1) 3%, tobacco flavor 5%, deionized water 9%, glycerol 40% and propylene glycol 43%.
When the electronic cigarette liquid is prepared, the components are prepared, then the components are mixed, and the mixture is stirred for 30min at normal temperature to fully mix the components.
1mL of electronic cigarette liquid containing the nicotine salt combination is placed in an electronic cigarette appliance to be smoked by a linear smoking machine, and the nicotine amount and mobility in 120-mouth aerosol are measured. The corresponding amount of nicotine in the electronic cigarette liquid in the 120-mouth aerosol is 5.78mg, the amount of nicotine released in the 120-mouth aerosol is 5.64mg, the mobility of nicotine is 97.45%, and the change of nicotine release in the aerosol during the sucking process is shown in figure 5.
From the above, the combination of the nicotine phosphate salt and the nicotine salt screened in the mobility experiment not only reduces the release amount of nicotine in aerosol, reduces the irritation of smoke, has better atomization amount, and improves the uniformity of smoke release.
Claims (1)
1. An electronic cigarette liquid containing nicotine salt is characterized by comprising nicotine salt, a fragrance-generating component, water and an atomizing component, wherein the nicotine salt consists of nicotine phosphate salt and other nicotine salt, and the other nicotine salt is one or two of nicotine tartrate salt and nicotine malate salt;
the nicotine phosphate accounts for 30-67% of the mass of the nicotine salt; the molar ratio of the acid to the nicotine in the tartaric acid nicotine salt is 1:1 or 2:1, and the molar ratio of the acid to the nicotine in the malic acid nicotine salt is 1:1;
the electronic cigarette liquid comprises the following components in percentage by mass: 2-4% of nicotine salt, 5-8% of aroma-generating component, 9-12% of water and the balance of atomizing component.
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| CN202011262568.2A CN114468344B (en) | 2020-11-12 | 2020-11-12 | Electronic cigarette liquid containing nicotine salt |
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| CN202011262568.2A CN114468344B (en) | 2020-11-12 | 2020-11-12 | Electronic cigarette liquid containing nicotine salt |
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| CN114468344A CN114468344A (en) | 2022-05-13 |
| CN114468344B true CN114468344B (en) | 2023-05-09 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106714589A (en) * | 2014-04-30 | 2017-05-24 | 奥驰亚客户服务有限责任公司 | Liquid aerosol formulation of an electronic smoking article |
| CN111602850A (en) * | 2019-05-31 | 2020-09-01 | 钟术光 | Aerosol generating or aerosolization system or electronic cigarette and device thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB754772A (en) * | 1954-05-24 | 1956-08-15 | Plate Ges Mit Beschraenkter Ha | Aromatic, mild tobacco with reduced nicotine content and process for the production thereof |
| GB1502132A (en) * | 1975-05-27 | 1978-02-22 | Ici Ltd | Smoking materials |
| US4464434A (en) * | 1978-03-13 | 1984-08-07 | Celanese Corporation | Microencapsulated alkaloidal material and method of producing same |
| CN105455190A (en) * | 2016-02-01 | 2016-04-06 | 湖北中烟工业有限责任公司 | Electronic cigarette liquid |
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- 2020-11-12 CN CN202011262568.2A patent/CN114468344B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106714589A (en) * | 2014-04-30 | 2017-05-24 | 奥驰亚客户服务有限责任公司 | Liquid aerosol formulation of an electronic smoking article |
| CN111602850A (en) * | 2019-05-31 | 2020-09-01 | 钟术光 | Aerosol generating or aerosolization system or electronic cigarette and device thereof |
Non-Patent Citations (1)
| Title |
|---|
| 不同烟碱盐对电子烟烟碱释放行为的影响;各会杰;张博;赵国玲;尹新强;李燕春;张峻松;;烟草科技(第03期);全文 * |
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