CN114076755B - Adjustable reference light source for chemiluminescent immunoassay analyzer - Google Patents
Adjustable reference light source for chemiluminescent immunoassay analyzer Download PDFInfo
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- CN114076755B CN114076755B CN202010846965.8A CN202010846965A CN114076755B CN 114076755 B CN114076755 B CN 114076755B CN 202010846965 A CN202010846965 A CN 202010846965A CN 114076755 B CN114076755 B CN 114076755B
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- reference light
- chemiluminescent immunoassay
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- 238000003018 immunoassay Methods 0.000 title claims abstract description 36
- 238000002834 transmittance Methods 0.000 claims abstract description 21
- 239000011148 porous material Substances 0.000 claims abstract description 20
- 230000010354 integration Effects 0.000 claims abstract description 18
- 238000012360 testing method Methods 0.000 abstract description 21
- 238000009792 diffusion process Methods 0.000 abstract description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 10
- 238000004020 luminiscence type Methods 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 4
- 230000002093 peripheral effect Effects 0.000 description 4
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- -1 polydimethylsiloxane Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
- G01N21/763—Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The invention discloses an adjustable reference light source for a chemiluminescent immunoassay analyzer, which comprises an integrating cavity body, a display panel, a controller and a luminescent piece, wherein the integrating cavity body is provided with a plurality of light emitting elements; the top plate of the integration cavity body is a pore plate, and a plurality of vertical through holes are formed in the pore plate; the light emitting part is arranged in the integrating cavity, and the controller is used for controlling the light transmittance of the part of the display panel corresponding to the position of each through hole; the display panel also comprises an attenuation sheet, wherein the attenuation sheet is arranged between the pore plate and the display panel; the inner wall of the integrating cavity is provided with a diffuse reflection layer; light diffusion gel is arranged in each through hole. The invention has low price and simple and convenient operation, and can provide a stable and continuous reference light source for the calibration or test of the chemiluminescence immunoassay analyzer.
Description
Technical Field
The invention particularly relates to an adjustable reference light source for a chemiluminescent immunoassay analyzer.
Background
The chemiluminescent immunoassay analyzer has the advantages of small background interference, high sensitivity, high accuracy, wide detectable range and good stability, can detect trace antigens or antibodies, and in recent years, the chemiluminescent immunoassay analyzer has rapidly developed into one of the most popular detection means in the immunodiagnosis field.
To ensure the instrument performance of the chemiluminescent immunoassay analyzer, the chemiluminescent immunoassay analyzer needs to be calibrated or tested frequently.
The light source for the chemiluminescent immunoassay analyzer comprises a pore plate (such as a 96-pore plate) which is provided with a plurality of through holes. When the chemiluminescent immunoassay analyzer is calibrated or tested by adopting the prior art, firstly, a reagent is required to be added into a centrifuge tube, then the centrifuge tube is placed into a target through hole to be calibrated or tested, and finally, the reagent chemically reacts in the centrifuge tube and emits light at the hole site of the corresponding target through hole.
The existing methods for calibrating or testing chemiluminescent immunoassay analyzers using reagents have the following disadvantages: the reagent is expensive, the stable light-emitting time is short, the reagent needs to be temporarily prepared before use, and the operation steps are complicated.
Disclosure of Invention
The invention aims to provide the adjustable reference light source for the chemiluminescent immunoassay analyzer, which aims at overcoming the defects of the prior art that the chemiluminescent immunoassay analyzer is calibrated or tested by using a reagent, has low price and simple and convenient operation, and can provide a stable and continuous reference light source for the calibration or test of the chemiluminescent immunoassay analyzer.
In order to solve the technical problems, the invention adopts the following technical scheme:
the adjustable reference light source for the chemiluminescent immunoassay analyzer is structurally characterized by comprising an integrating cavity body, a display panel, a controller and a luminescent piece; the top plate of the integration cavity body is a pore plate, and a plurality of vertical through holes are formed in the pore plate; the integration cavity is formed in the integration cavity body, all through holes are communicated with the integration cavity, the display panel is arranged on the pore plate and covers all the through holes on the pore plate, the luminous element is arranged in the integration cavity, and the controller is used for controlling the light transmittance of the part, corresponding to the position of each through hole, of the display panel.
By means of the structure, the luminous piece emits light, and the controller controls the light transmittance of the part of the display panel corresponding to the position of each through hole: when light emission is required from one or more through hole sites, the light transmittance at the positions of the display panel corresponding to the positions of the through holes requiring light emission is set to 100%, and the light transmittance at the positions of the display panel corresponding to the positions of the through holes not requiring light emission is set to 0%. In addition, the light transmittance of the display panel at the position corresponding to each through hole is set to be between 0 and 100 percent, so that the positions of each through hole can be controlled to obtain different light-emitting values.
Further, the display panel further comprises an attenuation sheet, and the attenuation sheet is arranged between the pore plate and the display panel.
Because the chemiluminescent immunoassay analyzer detector is generally a single photon detector, the detector is extremely saturated. The proper attenuation sheet is selected to properly attenuate the light emitted by the light-emitting piece, so that the detector of the chemiluminescent immunoassay analyzer can be ensured to work in an unsaturated region.
Further, a diffuse reflection layer is arranged on the inner wall of the integrating cavity.
The diffuse reflection layer on the inner wall of the integrating cavity can enable light emitted by the light emitting element to be uniformly distributed in the integrating cavity, and a precondition is provided for uniform light emission of the through holes on the pore plate.
Further, light diffusion gel is arranged in each through hole.
The light diffusion gel in the through hole uniformly diverges the light transmitted from the integrating cavity, thereby generating a luminescence characteristic similar to that of the reagent and effectively simulating reagent luminescence.
Preferably, the light emitting element is an LED lamp.
In a preferred mode, the LED lamp and the first driving circuit for driving the LED lamp are both arranged on the first side panel of the integration cavity body.
As a preferred mode, the display panel is an LCD panel.
As a preferred mode, the controller is electrically connected with the display panel through the second driving circuit.
Preferably, the controller and the second driving circuit are mounted on the second side panel of the integration cavity body.
As a preferred mode, the well plate is a 6-well plate, a 12-well plate, a 24-well plate, a 48-well plate, a 96-well plate, a 384-well plate or a 1536-well plate.
Compared with the prior art, the invention has low price and simple and convenient operation, and can provide a stable and continuous reference light source for the calibration or test of the chemiluminescent immunoassay analyzer.
Drawings
Fig. 1 is a left side view of an embodiment of the present invention.
Fig. 2 is a cross-sectional view A-A of fig. 1.
Fig. 3 is an exploded view of fig. 1.
Fig. 4 is a circuit block diagram of the display panel.
Fig. 5 is a schematic structural diagram of the integration cavity body.
FIG. 6 is a numbered schematic of a 96-well plate.
Wherein 1 is an integrating cavity body, 101 is an orifice plate, 1011 is a through hole, 102 is an integrating cavity, 103 is a first side panel, 104 is a second side panel, 2 is a display panel, 3 is a controller, 301 is a setting unit, 4 is a light emitting element, 5 is an attenuation sheet, 6 is a diffuse reflection layer, 7 is light diffusion gel, 8 is a first driving circuit, and 9 is a second driving circuit.
Detailed Description
As shown in fig. 1 to 4, the adjustable reference light source for the chemiluminescent immunoassay analyzer comprises an integrating cavity body 1, a display panel 2, a controller 3 and a luminescent element 4; the top plate of the integration cavity body 1 is a pore plate 101, and a plurality of vertical through holes 1011 are formed in the pore plate 101; the orifice plate 101 is a 6-orifice plate, a 12-orifice plate, a 24-orifice plate, a 48-orifice plate, a 96-orifice plate, a 384-orifice plate or a 1536-orifice plate, and in this embodiment, a 96-orifice plate is used, so that 96 through holes 1011 are formed in the orifice plate 101. An integrating cavity 102 is arranged in the integrating cavity body 1, each through hole 1011 is communicated with the integrating cavity 102, the display panel 2 is arranged on the pore plate 101 and covers all the through holes 1011 on the pore plate 101, the luminous element 4 is arranged in the integrating cavity 102, and the controller 3 is used for controlling the light transmittance of the part of the display panel 2 corresponding to the position of each through hole 1011. The light emitting part 4 emits light, and the controller 3 controls the light transmittance of the part of the display panel 2 corresponding to the position of each through hole 1011: when light is required to be emitted from one or a plurality of through holes 1011, the light transmittance at the positions of the display panel 2 corresponding to the positions of the through holes 1011 requiring light emission is set to 100%, and the light transmittance at the positions of the display panel 2 corresponding to the positions of the through holes 1011 not requiring light emission is set to 0%. In addition, the light transmittance of the display panel 2 at the position corresponding to each through hole 1011 can be set to be between 0% and 100%, so as to control the positions of each through hole 1011 to obtain different light emitting values. It can be seen that the present invention can provide a stable and continuous reference light source for calibration or testing of a chemiluminescent immunoassay analyzer by the controller 3 controlling the emission of each well of the 96-well plate 101 in real time controllable code.
The controller 3 is provided with a setting unit 301, and the setting unit 301 is used for setting the light transmittance of the positions corresponding to the positions of the through holes 1011 on the display panel 2 independently of each other.
The adjustable reference light source for the chemiluminescent immunoassay analyzer further comprises an attenuation sheet 5, wherein the attenuation sheet 5 is arranged between the pore plate 101 and the display panel 2. Because the chemiluminescent immunoassay analyzer detector is generally a single photon detector, the detector is extremely saturated. The proper attenuation sheet 5 is selected to attenuate the light emitted by the light emitting element 4, so that the chemiluminescent immunoassay analyzer detector can be ensured to work in an unsaturated region.
The inner wall of the integrating cavity 102 is provided with a diffuse reflection layer 6. The diffuse reflection layer 6 on the inner wall of the integrating cavity 102 can make the light emitted by the light emitting element 4 uniformly distributed in the integrating cavity 102, and provides a premise for uniform light emission of the through holes 1011 on the aperture plate 101. The diffuse reflection layer 6 is a magnesium oxide or barium sulfate coating, so that the diffuse reflection layer is guaranteed to have a high diffuse reflection coefficient (> 98%), and after the light emitting piece 4 emits light, the light source light is uniformly distributed in the cavity of the integrating cavity 102 through internal high diffuse reflection.
Light diffusing gel 7 is provided in each through hole 1011. The light diffusing gel 7 is shaped to match the shape of the through-hole 1011 and is fully embedded in the through-hole 1011. The light diffusion gel 7 in the through hole 1011 uniformly diffuses the light transmitted from the integrating cavity 102, thereby generating a light emission characteristic similar to that of the reagent, effectively simulating reagent light emission.
The light diffusion gel 7 can be a commercially available light diffusion gel or can be prepared by the prior art. For example, a dose of a light diffusing agent (e.g., spherical silicone resin micropowder) is doped into polydimethylsiloxane, and the mixture is left for 24 hours to solidify to form the light diffusing gel 7.
The luminous element 4 is an LED lamp. The LED lamp and the first driving circuit 8 (including a power supply) for driving the LED lamp are all mounted on the first side panel 103 of the integration cavity body 1.
The display panel 2 is an LCD panel with a size selected to be 5.7 feet to match the size of the 96-well plate 101. The controller 3 is electrically connected to the display panel 2 through a second driving circuit 9. The controller 3 and a second driving circuit 9 (including a power source) for driving the LCD panel are mounted on the second side panel 104 of the integrating cavity body 1. The mounting structure of the controller 3 and the second drive circuit 9 on the second side panel 104 is not shown in the drawings as being obscured, but does not affect the understanding and implementation of the present invention by those skilled in the art. In addition, the controller 3 is utilized to change the light transmittance at a certain position on the display panel 2 through a driving circuit, which is also a mature technology in the prior art, and is not described herein in detail, but does not affect the understanding and implementation of the present invention by those skilled in the art.
The integrating cavity body 1 is a cuboid-like body, the size of which is almost the same as that of the orifice plate 101. The left side of the integration cavity body 1 is detachably provided with a first side panel 103, and after the LED lamp and the first driving circuit 8 are arranged on the first side panel 103, the first side panel 103 seals the left side of the integration cavity 102; the second side panel 104 is detachably arranged on the right side of the integration cavity body 1, and after the controller 3 and the second driving circuit 9 are arranged on the second side panel 104, the second side panel 104 seals the right side of the integration cavity 102. The top of the integration cavity body 1 is provided with an orifice plate 101. The front panel, the rear panel and the bottom plate of the integration cavity body 1 are all fixed closed panels.
The invention adopts button battery to supply power, which can ensure smaller structure size.
A numbered schematic of a 96-well plate is shown in fig. 6.
The invention can provide stable and continuous programmable regulation and control reference light source for calibration or test (such as inter-hole interference test, channel difference test, stability test, repeatability test, linear test, inter-table difference calibration and the like) of the chemiluminescence immunoassay analyzer.
When the inter-hole interference test is performed, for example, when it is necessary to test the interference of the D7 hole site with its peripheral hole site, the light transmittance of the position on the display panel 2 corresponding to the D7 hole site is set to 100%, and the light transmittance of the position on the display panel 2 corresponding to the peripheral hole site of the D7 hole site is set to 0%, at which time theoretically only the D7 hole site should emit light. The detector is used for testing the optical signal of a certain peripheral hole site (such as C7 hole site) of the D7 hole site, if the detector obviously detects the optical signal, the luminescence of the D7 hole site is indicated to influence the detection of the peripheral hole site, namely, the inter-hole interference exists. Otherwise, if the detector does not detect the optical signal, then no inter-aperture interference exists.
When the channel difference test is performed, for example, when it is necessary to test the channel differences of the holes B2, B7, B11, D2, D7, D11, G2, G7, G11, the light transmittance at the position on the display panel 2 corresponding to the selected hole site is set to 100%, and the light transmittance at the position on the display panel 2 corresponding to the other hole sites is set to 0%. The luminescence values of the hole sites are tested by using the detector, in theory, the luminescence values of the selected hole sites should be basically the same, and if the test results among the hole sites have obvious differences, the result of the chemiluminescent immunoassay analyzer is different when different hole sites are tested, and errors among different hole sites exist.
When stability and repeatability tests are performed, for example, when stability and repeatability of the D7 hole site are required to be tested, light transmittance of the position corresponding to the D7 hole site on the display panel 2 is set according to the required intensity, light transmittance of the positions corresponding to the rest hole sites except the D7 hole site on the display panel 2 is set to 0%, and repeated tests are performed according to national standard requirements to verify the repeatability stability of the D7 hole site.
When a linear test is performed, for example, when testing the D7 hole site, the light transmittance of the corresponding position of the display panel 2 at the D7 hole site is set to 5%,10%,30%,50%,70% for 5, and the linear change of the optical signal at the D7 hole site is tested, thereby realizing the linear test.
The embodiments of the present invention have been described above with reference to the accompanying drawings, but the present invention is not limited to the above-described embodiments, which are merely illustrative and not restrictive, and many forms may be made by those having ordinary skill in the art without departing from the spirit of the present invention and the scope of the claims, which are all within the scope of the present invention.
Claims (10)
1. An adjustable reference light source for a chemiluminescent immunoassay analyzer, characterized in that:
comprises an integrating cavity body (1), a display panel (2), a controller (3) and a luminous element (4); the top plate of the integration cavity body (1) is a pore plate (101), and a plurality of vertical through holes (1011) are formed in the pore plate (101); an integrating cavity (102) is formed in the integrating cavity body (1), all through holes (1011) are communicated with the integrating cavity (102), the display panel (2) is arranged on the pore plate (101) and covers all through holes (1011) on the pore plate (101), the light emitting part (4) is arranged in the integrating cavity (102), and the controller (3) is used for controlling the light transmittance of the positions, corresponding to the positions of all through holes (1011), on the display panel (2).
2. The adjustable reference light source for a chemiluminescent immunoassay analyzer of claim 1 further comprising an attenuator (5), the attenuator (5) being disposed between the orifice plate (101) and the display panel (2).
3. The adjustable reference light source for a chemiluminescent immunoassay analyzer of claim 1 wherein the inner wall of the integrating cavity (102) is provided with a diffuse reflecting layer (6).
4. The adjustable reference light source for a chemiluminescent immunoassay analyzer of claim 1 wherein each of the through holes (1011) is provided with a light diffusing gel (7).
5. The adjustable reference light source for a chemiluminescent immunoassay analyzer of claim 1 wherein the light emitting element (4) is an LED lamp.
6. The adjustable reference light source for a chemiluminescent immunoassay analyzer of claim 5 wherein the LED lamp and the first drive circuit (8) for driving the LED lamp are mounted on a first side panel (103) of the integrating cavity body (1).
7. The adjustable reference light source for a chemiluminescent immunoassay analyzer according to claim 1 wherein the display panel (2) is an LCD panel.
8. The adjustable reference light source for a chemiluminescent immunoassay analyzer according to claim 1 wherein the controller (3) is electrically connected to the display panel (2) through a second drive circuit (9).
9. The adjustable reference light source for a chemiluminescent immunoassay analyzer of claim 8 wherein the controller (3) and the second drive circuit (9) are mounted on a second side panel (104) of the integrating cavity body (1).
10. The adjustable reference light source for a chemiluminescent immunoassay according to any one of claims 1-9 wherein the well plate (101) is a 6-well plate, a 12-well plate, a 24-well plate, a 48-well plate, a 96-well plate, a 384-well plate or a 1536-well plate.
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| CN202010846965.8A CN114076755B (en) | 2020-08-21 | 2020-08-21 | Adjustable reference light source for chemiluminescent immunoassay analyzer |
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| CN202010846965.8A CN114076755B (en) | 2020-08-21 | 2020-08-21 | Adjustable reference light source for chemiluminescent immunoassay analyzer |
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| CN114076755B true CN114076755B (en) | 2024-03-12 |
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