CN114053487A - Mechanical bionic absorption filler and manufacturing method thereof - Google Patents
Mechanical bionic absorption filler and manufacturing method thereof Download PDFInfo
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- CN114053487A CN114053487A CN202010764318.2A CN202010764318A CN114053487A CN 114053487 A CN114053487 A CN 114053487A CN 202010764318 A CN202010764318 A CN 202010764318A CN 114053487 A CN114053487 A CN 114053487A
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- sodium hyaluronate
- microspheres
- absorption filler
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- 239000011664 nicotinic acid Substances 0.000 title claims abstract description 15
- 238000010521 absorption reaction Methods 0.000 title claims abstract description 14
- 239000000945 filler Substances 0.000 title claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 10
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 30
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 30
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 30
- 239000000463 material Substances 0.000 claims abstract description 21
- 229920000728 polyester Polymers 0.000 claims abstract description 21
- 239000004005 microsphere Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000007853 buffer solution Substances 0.000 claims abstract description 10
- 239000006185 dispersion Substances 0.000 claims abstract description 7
- 239000012530 fluid Substances 0.000 claims abstract description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 4
- 229920001577 copolymer Polymers 0.000 claims abstract description 4
- 229920001519 homopolymer Polymers 0.000 claims abstract description 4
- 230000003204 osmotic effect Effects 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000008215 water for injection Substances 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims description 15
- 239000000839 emulsion Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 230000002745 absorbent Effects 0.000 claims description 4
- 239000002250 absorbent Substances 0.000 claims description 4
- 230000003592 biomimetic effect Effects 0.000 claims description 3
- 238000004945 emulsification Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 230000001413 cellular effect Effects 0.000 abstract 1
- 210000003722 extracellular fluid Anatomy 0.000 abstract 1
- 238000010008 shearing Methods 0.000 description 9
- 238000006731 degradation reaction Methods 0.000 description 7
- 230000015556 catabolic process Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 230000001815 facial effect Effects 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000003631 expected effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a method for manufacturing a mechanical bionic absorption filler, which comprises the following steps: the absorbable polyester microspheres are PLA, and/or PCL, and/or PGA, and PDO, and can absorb homopolymers and/or copolymers of a synthetic polyester material, the sodium hyaluronate is non-crosslinked high molecular weight sodium hyaluronate, the dispersion is buffer solution, and/or normal saline, and/or water for injection, and the osmotic pressure similar to cellular fluid and the pH value similar to interstitial fluid are provided for a product.
Description
Technical Field
The invention relates to the technical field of bionic absorption filling, in particular to a mechanical bionic absorption filling material and a manufacturing method thereof.
Background
The products currently on the market for facial filling have the following drawbacks: (1) because of the problems of materials or formula, the materials or the formula are incompatible in mechanics, too soft, easy to deform after being implanted, incapable of achieving the expected effect, and too hard, easy to form adverse reactions such as caking, nodules and the like; (2) the volume or physical property of the absorbable material can be changed along with degradation, so that the implanted material is deformed or displaced in the degradation process; (3) the most commonly used filling materials are those obtained by cross-linking sodium hyaluronate to improve the mechanical properties of the material, which has certain beneficial effects, but the cross-linking process increases the safety risk and cannot circumvent the above disadvantages.
Therefore, it is necessary for engineers skilled in the relevant art to develop a novel filling material, which can have the following properties:
(1) the viscoelasticity of the filling material approximates that of facial tissue;
(2) the viscoelasticity of the filling material does not change greatly within a certain degradation period;
(3) the material does not pose a new potential safety risk.
Disclosure of Invention
The invention aims to solve the technical problem of providing a mechanical bionic absorption filler with the properties of easy injection, degradability and no obvious change of viscoelasticity in the degradation process.
In order to solve the technical problems, the technical scheme of the invention is as follows:
a mechanical biomimetic absorbent padding comprising:
absorbable polyester microspheres, which are homopolymers, and/or copolymers of PLA, and/or PCL, and/or PGA, and PDO absorbable synthetic polyester materials;
sodium hyaluronate which is uncrosslinked high molecular weight sodium hyaluronate;
and the dispersion liquid is buffer solution, and/or normal saline and/or water for injection, provides the product with the osmotic pressure similar to cell fluid and the pH value similar to tissue fluid, and is further preferably PBS buffer solution.
Preferably, the absorbable polyester microspheres are 5-45, the sodium hyaluronate is 0.1-3, and the dispersion liquid is 52-94.9.
Preferably, the sodium hyaluronate is uncrosslinked high molecular weight sodium hyaluronate, and the molecular weight of the sodium hyaluronate is not less than 120 ten thousand, more preferably 180-260 ten thousand, and most preferably 220-240 ten thousand.
Preferably, the absorbable polyester microspheres range from 100nm to 100 μm, more preferably from 5 μm to 75 μm, and most preferably from 25 μm to 50 μm.
A manufacturing method of a mechanical bionic absorption filler is characterized by comprising the following steps:
s1, preparing the polyester material into microspheres with a certain particle size range by an emulsification volatilization method, an electrostatic spray method and/or a microfluidic method;
s2, stirring and dissolving the sodium hyaluronate in a PBS buffer solution, and homogenizing by using a high-speed homogenizer to form emulsion;
s3, adding the polyester microspheres into the emulsion, mixing, dispersing and removing bubbles in vacuum;
s4, vacuum filling the mixed liquid after vacuum defoaming into a pre-filling and sealing syringe
The invention has the beneficial effects that:
the invention has the advantages of easy injection, degradability and no obvious change of viscoelasticity in the degradation process, compared with the existing product, the filling material can provide more similar viscoelasticity for facial tissues, the viscoelasticity of the filling material does not change obviously in a certain degradation period, and the material does not cause new potential safety risk.
Drawings
FIG. 1 is a flow chart of a mechanical bionic absorbent filler and a manufacturing method thereof according to an embodiment of the present invention;
FIG. 2 is a viscoelastic curve diagram of an experiment of a mechanical bionic absorption filler and a manufacturing method according to an embodiment of the invention;
fig. 3 is a dynamic viscosity curve diagram of an experiment of the mechanical bionic absorption filler and the manufacturing method of the invention.
Detailed Description
The following further describes embodiments of the present invention with reference to the drawings. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
As shown in fig. 1-3, a mechanical biomimetic absorbent padding, comprising:
absorbable polyester microspheres, wherein the absorbable polyester microspheres are homopolymers and/or copolymers of PLA, and/or PCL, and/or PGA, and PDO absorbable synthetic polyester materials;
sodium hyaluronate, which is uncrosslinked high molecular weight sodium hyaluronate;
the dispersion is buffer solution, and/or normal saline, and/or water for injection, and provides the product with osmotic pressure similar to that of cell fluid and pH value similar to that of tissue fluid.
In a preferred embodiment of the present invention, the absorbable polyester microspheres are 5 to 45, the sodium hyaluronate is 0.1 to 3, and the dispersion is 52 to 94.9.
In the preferred embodiment of the invention, the sodium hyaluronate is uncrosslinked high molecular weight sodium hyaluronate, and the molecular weight of the sodium hyaluronate is more than or equal to 120 ten thousand.
In the preferred embodiment of the present invention, the absorbable polyester microspheres range from 100nm to 100 μm.
A manufacturing method of a mechanical bionic absorption filler comprises the following steps:
s1, preparing the polyester material into microspheres with a certain particle size range by an emulsification volatilization method, an electrostatic spray method and/or a microfluidic method;
s2, stirring and dissolving sodium hyaluronate in a PBS buffer solution, and homogenizing by using a high-speed homogenizer to form emulsion;
s3, adding the polyester microspheres into the emulsion, mixing, dispersing and removing bubbles in vacuum;
s4, vacuum filling the mixed liquid after vacuum defoaming into a pre-filling and sealing syringe
Specifically, other examples are as follows:
the first embodiment is as follows:
s1, adding 2.2 parts by weight of sodium hyaluronate powder with a molecular weight of 158 ten thousand into 62.8 parts by weight of PBS buffer, and stirring for 2 hours at a stirring speed of 150rpm to completely dissolve the sodium hyaluronate in the PBS buffer;
s2, pouring the dissolved solution into a mixing instrument, adding 35 parts by mass of PCL microspheres with the particle size range of 40-50 micrometers, and stirring while homogenizing and shearing for 30min at the stirring speed of 100rpm and the homogenizing and shearing speed of 10000 rpm;
closing homogenizing and shearing, starting a vacuum pump, pumping the vacuum degree in the container to be below-0.08 MPa, keeping for 2 hours, and eliminating bubbles to be uniformly mixed;
example two:
s1, adding 2 parts by weight of sodium hyaluronate powder with the molecular weight of 200 ten thousand into 88 parts by weight of physiological saline, and stirring for 2 hours at a stirring speed of 150rpm to completely dissolve the sodium hyaluronate in the physiological saline;
s2, pouring the dissolved solution into a mixing instrument, adding 10 parts by mass of PLGA microspheres with the particle size range of 10-45 microns, and carrying out homogenizing and shearing for 30min while stirring at the stirring speed of 100rpm and the homogenizing and shearing speed of 10000 rpm;
closing homogenizing and shearing, starting a vacuum pump, pumping the vacuum degree in the container to be below-0.08 MPa, keeping for 2 hours, and eliminating bubbles to be uniformly mixed;
example three:
s1, adding 1.2 parts by weight of sodium hyaluronate powder with the molecular weight of 300 ten thousand into 73.8 parts by weight of PBS buffer solution, and stirring for 2 hours at the stirring speed of 150rpm to completely dissolve the sodium hyaluronate in the PBS buffer solution;
s2, pouring the dissolved solution into a mixing instrument, adding 25 parts by mass of PGCL microspheres with the particle size range of 20-75 micrometers, and carrying out homogenizing and shearing for 30min while stirring at the stirring speed of 100rpm and the homogenizing and shearing speed of 10000 rpm;
closing homogenizing and shearing, starting a vacuum pump, pumping the vacuum degree in the container to be below-0.08 MPa, keeping for 2 hours, and eliminating bubbles to be uniformly mixed;
the cross point of the viscoelastic modulus, the viscoelastic curve and the dynamic viscosity curve of the embodiment of the product are detected, and the performance of the embodiment of the product shows the performance which is very similar to that of animal soft tissues, and the performance is not obviously changed before and after degradation.
The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, and the scope of protection is still within the scope of the invention.
Claims (5)
1. A mechanical biomimetic absorbent padding, comprising:
absorbable polyester microspheres, which are homopolymers, and/or copolymers of PLA, and/or PCL, and/or PGA, and PDO absorbable synthetic polyester materials;
sodium hyaluronate which is uncrosslinked high molecular weight sodium hyaluronate;
and the dispersion is buffer solution, and/or normal saline and/or water for injection, and provides the product with osmotic pressure similar to that of cell fluid and pH value similar to that of tissue fluid.
2. The mechanical bionic absorption filler as claimed in claim 1, wherein the number of the absorbable polyester microspheres is 5-45, the number of the sodium hyaluronate is 0.1-3, and the number of the dispersion liquid is 52-94.9.
3. The mechanical bionic absorption filler as claimed in claim 1, wherein the sodium hyaluronate is non-crosslinked high molecular weight sodium hyaluronate, and the molecular weight of the sodium hyaluronate is not less than 120 ten thousand.
4. The mechanical bionic absorption filler as claimed in claim 1, wherein the range of the absorbable polyester microspheres is 100 nm-100 μm.
5. The method for manufacturing the mechanical bionic absorption filler according to the claims 1 to 4, characterized by comprising the following steps:
s1, preparing the polyester material into microspheres with a certain particle size range by an emulsification volatilization method, an electrostatic spray method and/or a microfluidic method;
s2, stirring and dissolving the sodium hyaluronate in a PBS buffer solution, and homogenizing by using a high-speed homogenizer to form emulsion;
s3, adding the polyester microspheres into the emulsion, mixing, dispersing and removing bubbles in vacuum;
and S4, vacuum filling the mixed liquid after vacuum defoaming into the pre-filling and sealing syringe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010764318.2A CN114053487A (en) | 2020-08-02 | 2020-08-02 | Mechanical bionic absorption filler and manufacturing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010764318.2A CN114053487A (en) | 2020-08-02 | 2020-08-02 | Mechanical bionic absorption filler and manufacturing method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN114053487A true CN114053487A (en) | 2022-02-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010764318.2A Pending CN114053487A (en) | 2020-08-02 | 2020-08-02 | Mechanical bionic absorption filler and manufacturing method thereof |
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| Country | Link |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114601966A (en) * | 2022-03-30 | 2022-06-10 | 浙江景嘉医疗科技有限公司 | Sodium hyaluronate gel lubricating liquid, filler, preparation method and application thereof |
| CN116421779A (en) * | 2023-03-29 | 2023-07-14 | 云南贝泰妮生物科技集团股份有限公司 | Preparation method of injectable sodium hyaluronate coated polylactic acid microsphere |
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2020
- 2020-08-02 CN CN202010764318.2A patent/CN114053487A/en active Pending
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114601966A (en) * | 2022-03-30 | 2022-06-10 | 浙江景嘉医疗科技有限公司 | Sodium hyaluronate gel lubricating liquid, filler, preparation method and application thereof |
| CN116421779A (en) * | 2023-03-29 | 2023-07-14 | 云南贝泰妮生物科技集团股份有限公司 | Preparation method of injectable sodium hyaluronate coated polylactic acid microsphere |
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