CN114042197B - Device for absorbing urea toxins by superfine fiber soft material tows and application method thereof - Google Patents
Device for absorbing urea toxins by superfine fiber soft material tows and application method thereof Download PDFInfo
- Publication number
- CN114042197B CN114042197B CN202111486417.XA CN202111486417A CN114042197B CN 114042197 B CN114042197 B CN 114042197B CN 202111486417 A CN202111486417 A CN 202111486417A CN 114042197 B CN114042197 B CN 114042197B
- Authority
- CN
- China
- Prior art keywords
- superfine fiber
- fiber soft
- silica gel
- soft material
- peritoneal dialysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000835 fiber Substances 0.000 title claims abstract description 69
- 239000007779 soft material Substances 0.000 title claims abstract description 34
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title claims abstract description 24
- 239000004202 carbamide Substances 0.000 title claims abstract description 24
- 239000003053 toxin Substances 0.000 title claims abstract description 15
- 231100000765 toxin Toxicity 0.000 title claims abstract description 15
- 108700012359 toxins Proteins 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title abstract description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 47
- 239000000741 silica gel Substances 0.000 claims abstract description 47
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 47
- 238000000502 dialysis Methods 0.000 claims abstract description 43
- 239000000385 dialysis solution Substances 0.000 claims abstract description 22
- 239000000126 substance Substances 0.000 claims abstract description 16
- 239000007788 liquid Substances 0.000 claims description 39
- 239000002699 waste material Substances 0.000 claims description 36
- 210000000683 abdominal cavity Anatomy 0.000 claims description 28
- 238000001802 infusion Methods 0.000 claims description 24
- 238000007789 sealing Methods 0.000 claims description 14
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 8
- 239000003330 peritoneal dialysis fluid Substances 0.000 claims description 8
- 210000003200 peritoneal cavity Anatomy 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 4
- 239000011787 zinc oxide Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 2
- 230000007797 corrosion Effects 0.000 claims description 2
- 238000005260 corrosion Methods 0.000 claims description 2
- 238000010041 electrostatic spinning Methods 0.000 claims description 2
- 230000005389 magnetism Effects 0.000 claims description 2
- 238000003672 processing method Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 239000000155 melt Substances 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 abstract description 6
- 238000001179 sorption measurement Methods 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 4
- 210000004369 blood Anatomy 0.000 abstract description 4
- 230000003204 osmotic effect Effects 0.000 abstract description 4
- 238000012546 transfer Methods 0.000 abstract description 3
- 239000002441 uremic toxin Substances 0.000 abstract description 3
- 230000002792 vascular Effects 0.000 abstract description 3
- 230000003187 abdominal effect Effects 0.000 description 13
- 238000001631 haemodialysis Methods 0.000 description 7
- 230000000322 hemodialysis Effects 0.000 description 7
- 230000010412 perfusion Effects 0.000 description 6
- 210000004379 membrane Anatomy 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 230000002503 metabolic effect Effects 0.000 description 4
- 229920001410 Microfiber Polymers 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000003792 electrolyte Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 238000002324 minimally invasive surgery Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 238000005381 potential energy Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 1
- 208000012639 Balance disease Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/282—Operational modes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/287—Dialysates therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- External Artificial Organs (AREA)
Abstract
The invention discloses a device for absorbing uremic toxins by superfine fiber soft material tows and a use method thereof. The fiber surface of the superfine fiber soft material tows with a certain length can continuously adsorb substances such as urea in the peritoneal dialysis solution, so that the concentration of urea in the dialysis solution is reduced, the tows among the small silica gel balls can be dispersed, the adsorption efficiency of the tows is increased, the urea in the dialysis solution can keep a lower concentration for a longer time, toxins in blood can continuously transfer into the peritoneal dialysis solution through the vascular wall under the driving of osmotic pressure, the use time of the dialysis solution can be greatly prolonged, the replacement frequency of the dialysis solution is reduced, the use time of the dialysis solution is further prolonged, the peritoneal dialysis frequency is reduced, and the peritoneal dialysis period is prolonged.
Description
Technical Field
The invention relates to the field of clinical medical treatment, in particular to a dialysis device and a method used in peritoneal dialysis.
Background
Renal failure is a pathological condition of decline of renal function in humans, which can cause the inability of patients to excrete endotoxin, maintain the stability of electrolytes such as sodium, potassium, calcium, etc. and the acid-base balance of the human system. Early chronic renal failure can be treated by drugs, but when the condition deteriorates to the uremic state, it is necessary for the patient to adopt a treatment method of hemodialysis or peritoneal dialysis for a lifetime other than the renal transplantation treatment.
Hemodialysis is a process of introducing the patient's blood and dialysate into an extracorporeal dialysis apparatus simultaneously, removing excessive toxins and excessive moisture accumulated in the blood by using a semipermeable membrane of the dialysis apparatus, supplementing bases to correct acidosis, and adjusting electrolyte disorders to replace the excretory function of the kidneys. In the dialysis treatment process, hemodialysis can rapidly remove solutes and water of small molecules, but the hemodialysis can rapidly lose the functions of the residual kidneys and has great influence on blood circulation in vivo, so that the blood-vessel-free dialysis liquid is not suitable for people suffering from heart failure, poor vascular conditions, mental disorders and the like. Thus, when the patient's peritoneal membrane is well functioning and unsuitable for hemodialysis, the method of peritoneal dialysis is considered.
Peritoneal dialysis is to use the peritoneal membrane as a semipermeable membrane, infuse dialysate into the peritoneal cavity through an abdominal tube, remove toxins through dispersion, correct electrolyte and acid-base balance disorder, and achieve ultrafiltration dehydration through the osmosis principle (glucose is added into the dialysate to increase the osmotic pressure of the dialysate) so as to replace the excretion function of the kidney. Compared with hemodialysis, the peritoneal dialysis is performed at home, and the peritoneal dialysis can be performed by oneself or by family members, so that the peritoneal dialysis solution is infused into the peritoneal cavity only through the peritoneal dialysis tube, the dialysis equipment is relatively simple, the residual kidney function of a patient is well protected, and the influence and the requirement on the heart function are small. Patients undergoing peritoneal dialysis are required to face long-term, high frequency treatment afflictions. In contrast to treatment hemodialysis performed 3-4 times per week, peritoneal dialysis is performed daily, and in some cases 3-4 times per day, severely affecting the patient's normal life.
Therefore, how to reduce the frequency of peritoneal dialysis and prolong the period of peritoneal dialysis, and the normal life of patients is not affected while the treatment effect of the patients is ensured, which is a key problem to be solved by the current peritoneal dialysis treatment method.
Disclosure of Invention
The invention aims at the defects of the existing peritoneal dialysis technology, innovates the peritoneal dialysis method and device, introduces a superfine fiber soft material tow into the peritoneal cavity on the basis of the traditional gravity peritoneal dialysis, and continuously adsorbs substances such as urea in the dialysate by the superfine fiber surface containing materials (such as zinc oxide particles) capable of adsorbing toxic substances such as urea and the like, thereby reducing the concentration of urea in the dialysate, further keeping the dialysate at a larger osmotic pressure for a longer time, prolonging the service time of the dialysate and reducing the dialysis frequency.
The technical scheme of the invention is as follows: a device for absorbing urea toxins by superfine fiber soft substance tows comprises a peritoneal dialysis liquid conveying and changing system, an abdominal tube, an abdominal interface, an iodophor cap and superfine fiber soft substance tows, wherein the peritoneal dialysis liquid conveying and changing system comprises a dialysis liquid bag, a liquid conveying tube, a sealing plug, a waste liquid bag, a waste liquid tube and a three-way ball valve. The dialysate bag is sealed well, ensures that the dialysate is not polluted by external environment, and the sealing plug is located at the outlet of the dialysate bag, seals the dialysate bag, breaks the sealing plug, can enable the dialysate to flow into the infusion tube, and the three-way ball valve is connected at the tail end of the infusion tube and can be connected with the abdominal cavity interface and the waste liquid tube simultaneously to control the connection of the three pipelines. The end of the waste liquid pipe is connected with a waste liquid bag, the waste liquid bag is required to be sealed well, and waste liquid can not flow into the external environment to pollute the environment. The abdominal joint connected with the three-way ball valve is made of titanium alloy, has the advantages of high strength, corrosion resistance and no magnetism, one end outside the abdominal tube body is connected with the abdominal joint, the other end is placed into the abdominal cavity through minimally invasive surgery, and the abdominal tube is prepared from polymers with good biocompatibility. The end part of the infusion tube is provided with a superfine fiber soft substance filament bundle storage structure, the cross section of the structure is three-quarter circle, and the superfine fiber soft substance filament bundle can be clamped in the structure. The superfine fiber soft material filament bundle consists of superfine fiber, support filament, small silica gel balls and one large silica gel ball with diameter slightly larger than that of the abdominal cavity joint. When the superfine fiber soft material tows flow along with the peritoneal dialysis fluid, the large silica gel balls are clamped at the peritoneal dialysis interface, and the small silica gel balls flow into the peritoneal cavity along with the peritoneal dialysis fluid. The iodophor cap is connected with the abdominal cavity interface, can completely cover the large silica gel ball, and ensures sealing. The fiber is prepared from a polymer with biological safety, the surface of the fiber contains an adsorption material of metabolic wastes such as urea, and the small silica gel ball-to-ball constrained fiber continuously adsorbs the metabolic wastes in the peritoneal dialysis solution, so that the urine poison in the peritoneal dialysis solution is always kept at a low concentration, the use time of the dialysis solution is greatly prolonged, the replacement frequency of the dialysis solution is reduced, the peritoneal dialysis frequency is reduced, and the peritoneal dialysis period is prolonged.
The raw materials of the fiber tows in the device for absorbing urea toxins by using the superfine fiber soft material tows are material blends of polymers with biological safety, zinc oxide and other absorbable metabolic wastes, and the blends are used for preparing superfine fibers by safe and reliable processing methods such as melt differential electrostatic spinning and the like, so that fiber matrixes and absorbent particles are reliably combined and do not fall off. The length of the filament bundle is about 1.5-3 times of that of the peritoneal dialysis tube, so that when the large silica gel ball is clamped at the abdominal cavity interface, the filament bundle in the abdominal cavity has enough length, thereby increasing the area of the fiber scanning in the abdominal cavity and increasing the efficiency of the fiber bundle for absorbing metabolic wastes. The middle section of the fiber bundle is restrained by a plurality of small silica gel balls, so that the fiber bundle can not be intertwined when the fiber bundle is soaked or flows through the dialyzate, and the fiber bundle can be ensured to smoothly enter the abdominal cavity and can be unfolded in the abdominal cavity. Holes are formed in the surface of the large silica gel ball, so that the large silica gel ball is clamped by forceps, and the whole silk bundle is conveniently taken out of the abdominal cavity. The middle of the superfine fiber tows contains supporting filaments with the diameter of 100-300 microns, the supporting filaments are made of the same material as the superfine fibers, and the supporting filaments can be filaments or yarns, so that when the superfine fiber soft substance tows are taken out from the abdominal cavity, the supporting filaments can bear larger breaking force, and the tows are ensured not to break in the abdominal cavity. The support wire may also be made of other materials with high strength that are biosafety, the diameter being determined by the tension that needs to be borne.
The invention relates to a use method of a device for absorbing urea toxins by superfine fiber soft material tows, wherein one end of an abdominal permeation tube is placed into an abdominal cavity through minimally invasive surgery, one end outside an abdominal permeation tube body is connected with an abdominal cavity joint, a sealing plug is broken off to enable dialysate to flow out of a dialysate bag, a three-way ball valve is rotated to enable the abdominal permeation tube to be communicated with a perfusion tube, when stable dialysate flow exists in the perfusion tube, a storage structure on the perfusion tube is extruded, small silica gel balls are sequentially extruded into the perfusion tube from the tail end of the perfusion tube, each small silica gel ball is extruded, after tows among the small silica gel balls are completely unfolded, the next small silica gel ball is extruded, when the dialysate injection amount in the abdominal cavity is enough, a large silica gel ball is extruded, flows along with the dialysate and is clamped at an abdominal cavity joint, the three-way ball valve is rotated to close the perfusion tube, a peritoneal dialysis transfusion system is pulled out, and the large silica gel ball is covered by an iodophor cover and is tightly connected with the abdominal cavity joint. When the dialysis fluid is stored in the body for a set time, the iodophor cap is taken down, the holes of the large silica gel balls are clamped by forceps, the superfine fiber soft material tows are taken out, then a new peritoneal dialysis fluid delivery and exchange system is connected to the peritoneal interface, the three-way ball valve is rotated to enable the peritoneal dialysis fluid delivery tube to be connected with the waste liquid tube, the waste liquid bag is placed on the ground, the waste liquid is introduced into the waste liquid bag through the action of gravitational potential energy, the three-way interface is rotated after the waste liquid is drained, the infusion tube is connected with the peritoneal dialysis fluid and the superfine fiber soft material tows are injected into the peritoneal cavity again.
According to the device for absorbing urea by the superfine fiber soft material tows and the application method thereof, as the superfine fiber surfaces contain the absorbing materials capable of absorbing urea such as zinc oxide and the like, substances such as urea in peritoneal dialysis solution can be continuously absorbed, so that the concentration of urea in the dialysis solution is reduced. The fiber bundles in the abdominal cavity have sufficient length, and the fiber bundles between the small silica gel balls can be dispersed, so that the adsorption efficiency of the fiber bundles is increased, the concentration of urea in the dialysate is kept low for a long time, toxins in blood continuously transfer into the abdominal cavity permeate through the vascular wall under the drive of osmotic pressure, the service time of the dialysate can be greatly prolonged, and the effects of reducing the replacement frequency of the dialysate, improving the service time of the dialysate, reducing the peritoneal dialysis frequency and prolonging the peritoneal dialysis period are achieved.
Drawings
FIG. 1 is a schematic diagram of an apparatus for adsorbing urine toxins with a tow of ultra fine fiber soft material according to the present invention.
FIG. 2 is a schematic diagram of a peritoneal dialysis fluid transfer system of a device for adsorbing uremic toxins with a superfine fiber soft material tow according to the present invention.
FIG. 3 is a schematic view of an apparatus for adsorbing uremic toxins from a superfine fiber soft matter tow according to the present invention.
FIG. 4 is a schematic diagram showing a filament bundle storage structure on a transfusion tube of a device for absorbing urine poison by using a superfine fiber soft material filament bundle.
FIG. 5 is a schematic view showing the adsorption of urea and other substances by the ultrafine fiber soft substance tows in the abdominal cavity after transfusion
In the figure: 1-an abdominal penetration tube; 2-abdominal cavity interface; 3-iodophor cap; 4-ultra-fine fiber soft material tows; 4-1, a small silica gel ball at the front end; 4-2-middle small silica gel ball; 4-3-small silica gel balls at the rear end; 4-superfine fiber; 4-5-supporting wires; 4-6-big silica gel ball; 5-abdominal cavity; 6-a three-way ball valve; 7-a tow storage structure; 8, a dialysate bag; 9-a sealing plug; 10-an infusion tube; 11-a waste liquid pipe; 12-waste liquid bag.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.
The invention provides a device for absorbing urea toxins by superfine fiber soft material tows, which is shown in figure 1 and mainly comprises a peritoneal dialysis liquid conveying and changing system, an abdominal permeability tube 1, an abdominal cavity interface 2 and superfine fiber soft material tows 4. The peritoneal dialysis infusion and exchange system consists of a three-way ball valve 6, a tow storage structure 7, a dialysis fluid bag 8, a sealing plug 9, an infusion tube 10, a waste liquid tube 11 and a waste liquid bag 12, wherein the three-way ball valve 6 is positioned at the joint of the abdominal cavity interface 2, the infusion tube 10 and the waste liquid tube 11, the mutual communication of the abdominal cavity interface 1, the infusion tube 10 and the waste liquid tube 11 is controlled, the tail end part of the infusion tube 10 comprises the tow storage structure 7 for storing superfine fiber soft material tows 4, the other end of the infusion tube 10 is connected with the dialysis fluid bag 8, the sealing plug 9 is arranged at the bag mouth of the dialysis fluid bag 8, and the opening and closing of the bag mouth of the dialysis fluid bag 8 are controlled. And the other end of the waste liquid pipe 11 is connected with the three-way ball valve 6, and the other end of the waste liquid pipe is connected with the waste liquid bag 12. The superfine fiber soft material filament bundle 4 consists of a small silica gel ball 4-1 at the front end, a small silica gel ball 4-2 at the middle end, a small silica gel ball 4-3 at the rear end, superfine fibers 4-4, supporting wires 4-5 and a large silica gel ball 4-6, and is shown in figure 3. The infusion tube 10 is provided with a tow storage structure 7, as shown in fig. 4, the cross section of the tow storage structure 7 is three-quarter circle, a small silica gel ball 4-1 at the front end is positioned at one end of the tow storage structure 7 close to the three-way ball valve 6, a large silica gel ball 4-6 is positioned at the other end of the tow storage structure 7, and the whole superfine fiber soft material tow 4 is clamped by the tow storage structure 7.
The invention provides a use method of a device for absorbing urea toxins by superfine fiber soft material tows, which comprises the following steps of firstly, breaking a sealing plug 9 at the outlet of a dialysate bag 8, enabling dialysate to flow into a transfusion tube 10 from the dialysate bag 8, and rotating a three-way ball valve 6 to enable an abdominal permeation tube 1 to be communicated with the transfusion tube 10. When the flow of the dialysate in the infusion tube 10 is stable, the front small silica gel ball 4-1 in the tow storage structure 7 is pressed into the infusion tube 10, and when the front small silica gel ball 4-1 flows along with the dialysate and drives the superfine fibers 4-4 and the supporting wires 4-5 to be fully unfolded in the liquid flow, the middle small silica gel ball 4-2 is sequentially pressed into the infusion tube 10. And thirdly, when the amount of the peritoneal dialysis solution in the peritoneal cavity 5 reaches a preset value, pressing the large silica gel ball 4-6 into the infusion tube 10, enabling the large silica gel ball 4-6 to flow along with the dialysis solution, and when the large silica gel ball 4-6 is clamped at the peritoneal interface 2, rotating the three-way ball valve 6 to close the infusion tube 10. And step four, extracting the peritoneal dialysis infusion and exchange system, and covering the large silica gel ball 4-6 by using the iodophor cap 3, wherein the superfine fiber soft substance tows 4 adsorb substances such as urea in the abdominal cavity 5, and the adsorption process can be kept for a long time, as shown in fig. 5. And fifthly, when the dialysate is stored in the body for a prescribed time and then is subjected to the second peritoneal dialysis, the iodophor cap 3 at the peritoneal interface 2 is taken down, holes on the large silica gel balls 4-6 are clamped by forceps, the superfine fiber soft material tows 4 are taken out, and then a new peritoneal dialysis transfusion and exchange system is connected to the peritoneal interface 2. Step six, rotating the three-way ball valve 6 to enable the peritoneal dialysis catheter 1 to be connected with the waste liquid catheter 11, placing the waste liquid bag 12 on the ground, introducing waste liquid into the waste liquid bag 12 under the action of gravitational potential energy, rotating the three-way ball valve 6 after drainage of the waste liquid is finished to enable the waste liquid catheter 11 to be closed, and repeating the steps one to four.
Claims (3)
1. A device for absorbing urea toxins by superfine fiber soft material tows is characterized in that: the peritoneal dialysis infusion and exchange system comprises a dialysis fluid bag, a transfusion tube, a sealing plug, a waste liquid bag, a waste liquid tube and a three-way ball valve; the dialysate bag is well sealed, the dialysate is prevented from being polluted by external environment, the sealing plug is positioned at the outlet of the dialysate bag, the dialysate bag is sealed, the sealing plug is broken, the dialysate can flow into the infusion tube, the three-way ball valve is connected at the tail end of the infusion tube and connected with the abdominal cavity interface and the waste liquid tube, and the three-way ball valve controls the connection of three pipelines; the end of the waste liquid pipe is connected with a waste liquid bag, and the abdominal cavity joint connected with the three-way ball valve is made of titanium alloy, so that the advantages of high strength, corrosion resistance and no magnetism are achieved; the end part of the infusion tube is provided with a superfine fiber soft material filament bundle storage structure, the superfine fiber soft material filament bundle consists of superfine fibers, a plurality of small silica gel balls and a large silica gel ball, the large silica gel ball is positioned at one end of the superfine fiber soft material filament bundle, the small silica gel balls are positioned at the other end and the middle section of the superfine fiber soft material filament bundle, and the diameter of the large silica gel ball is slightly larger than the inner hole of the abdominal cavity joint; when the superfine fiber soft material tows flow along with the peritoneal dialysis fluid, the large silica gel balls are clamped at the peritoneal joint of the peritoneal dialysis interface, and the small silica gel balls flow into the peritoneal cavity along with the peritoneal dialysis fluid; the iodophor cap is in threaded sealing connection with the abdominal cavity interface, so that the large silica gel ball can be completely covered, and sealing is ensured; the raw material of the superfine fiber soft material tow is a blend of a polymer with biological safety and zinc oxide, and superfine fibers are prepared by a melt differential electrostatic spinning processing method; the length of the superfine fiber soft material filament bundle is 1.5-3 times of that of the peritoneal dialysis tube, and the middle section of the superfine fiber soft material filament bundle is restrained by a plurality of small silica gel balls which are uniformly distributed; the middle of the superfine fiber soft substance filament bundle contains supporting filaments with the diameter of 100-300 microns, the supporting filaments are made of the same material as the superfine fiber soft substance filament bundle, and the supporting filaments are filaments or yarns.
2. The device for absorbing urea toxins by the superfine fiber soft material tows according to claim 1, wherein: the end part of the infusion tube is provided with a superfine fiber soft substance filament bundle storage structure, the cross section of the infusion tube is three-quarter circle, and the superfine fiber soft substance filament bundle can be clamped in the structure.
3. The device for absorbing urea toxins by the superfine fiber soft material tows according to claim 1, wherein: the surface of the large silica gel ball is provided with holes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111486417.XA CN114042197B (en) | 2021-12-07 | 2021-12-07 | Device for absorbing urea toxins by superfine fiber soft material tows and application method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111486417.XA CN114042197B (en) | 2021-12-07 | 2021-12-07 | Device for absorbing urea toxins by superfine fiber soft material tows and application method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114042197A CN114042197A (en) | 2022-02-15 |
| CN114042197B true CN114042197B (en) | 2024-04-23 |
Family
ID=80212317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111486417.XA Active CN114042197B (en) | 2021-12-07 | 2021-12-07 | Device for absorbing urea toxins by superfine fiber soft material tows and application method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114042197B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1471936A (en) * | 1973-07-05 | 1977-04-27 | Sartorius Membranfilter Gmbh | Apparatus for an method of removing substances intended for excretion in the urine from blood |
| CN102202702A (en) * | 2008-11-03 | 2011-09-28 | 弗雷泽纽斯医疗保健控股有限公司 | Portable peritoneal dialysis system |
| CN202497521U (en) * | 2012-02-15 | 2012-10-24 | 四川大学华西医院 | Peritoneal dialysis system |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291122B2 (en) * | 2000-03-24 | 2007-11-06 | Immunocept, L.L.C. | Hemofiltration methods for treatment of diseases in a mammal |
| US11331597B2 (en) * | 2019-08-05 | 2022-05-17 | Fresenius Medical Care Holdings, Inc. | Cation exchange materials for dialysis systems |
-
2021
- 2021-12-07 CN CN202111486417.XA patent/CN114042197B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1471936A (en) * | 1973-07-05 | 1977-04-27 | Sartorius Membranfilter Gmbh | Apparatus for an method of removing substances intended for excretion in the urine from blood |
| CN102202702A (en) * | 2008-11-03 | 2011-09-28 | 弗雷泽纽斯医疗保健控股有限公司 | Portable peritoneal dialysis system |
| CN202497521U (en) * | 2012-02-15 | 2012-10-24 | 四川大学华西医院 | Peritoneal dialysis system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114042197A (en) | 2022-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104968376B (en) | For delivering the fluid circuit of renal replacement therapy | |
| US6849183B2 (en) | Method and apparatus for therapeutic apheresis | |
| US4488961A (en) | One-way filter unit | |
| CN101505811B (en) | Device for removing fluid from blood in a patient | |
| US11266772B2 (en) | Use of heparin and carbohydrates to treat cancer | |
| CN1154522C (en) | Apparatus and method for treatment of acute and chronic renal disease by continuous passive plasma ultrafiltration | |
| JP5872638B2 (en) | Peritoneal dialysis system | |
| CA2828897C (en) | Implantable systems and methods for removing specific impurities from fluids such as blood | |
| CN105025951A (en) | System and method for multi-functional volumetric fluid control | |
| WO1999059655A1 (en) | Apparatus and method for in vivo hemodialysis | |
| US4309992A (en) | Microbicidal filter | |
| GB2506010A (en) | Microneedle device for removal of bodily fluid | |
| JP4195858B2 (en) | Plasma export filter device and apparatus for apheresis therapy | |
| CN114042197B (en) | Device for absorbing urea toxins by superfine fiber soft material tows and application method thereof | |
| JP2001245970A (en) | Priming processing method for blood circuit | |
| AU2002335069A1 (en) | Plasmapheresis filter device and apparatus for therapeutic apheresis | |
| CN101164628A (en) | Device for purifying blood and application thereof | |
| Chang | Microcapsule artificial kidney in replacement of renal function. With emphasis on adsorbent hemoperfusion | |
| CN218356829U (en) | Extracorporeal circulation connecting pipe for hemodialysis | |
| CN218793314U (en) | Infusion apparatus for hemodialysis room | |
| CN210873413U (en) | Infusion apparatus for hemodialysis | |
| CN205108510U (en) | Portable blood purifies nursing device | |
| CN109758631A (en) | A kind of absorption type haemodialyser | |
| CN205649690U (en) | Anti -blocking pipe's blood purge tube feedback device | |
| CN109758630A (en) | A kind of absorption type haemodialyser |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |