CN114028327B

CN114028327B - Oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride and preparation and application methods thereof

Info

Publication number: CN114028327B
Application number: CN202111604119.6A
Authority: CN
Inventors: 许力心; 孙慧; 蔡飞翔; 齐迎珍; 魏雪倩
Original assignee: Xiling Zhenjiang Medical Technology Co ltd
Current assignee: Xiling Zhenjiang Medical Technology Co ltd
Priority date: 2021-12-24
Filing date: 2021-12-24
Publication date: 2023-09-12
Anticipated expiration: 2041-12-24
Also published as: CN114028327A

Abstract

The invention discloses an oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride, and a preparation method and a use method thereof, wherein the effective components of the antibacterial gel comprise baicalin extract, honeysuckle extract, pseudo-ginseng extract, ectoin and strontium chloride; and the mass percentage of each component is as follows: 1 to 3 percent of ectoin, 1 to 5 percent of strontium chloride, 1 to 5 percent of baicalin extract, 1 to 7 percent of honeysuckle extract, 1 to 5 percent of pseudo-ginseng extract, 0.5 to 1 percent of carbomer and the balance of deionized water. The invention takes the Chinese herbal medicine components as the main components, does not contain any antibiotic components, does not cause periodontitis bacteria to generate drug resistance, and has no side effect on human bodies; the antibacterial gel can promote the repair of alveolar bone injury by adding the ectoin and the strontium chloride, reduce the osteoblast injury under the synergistic effect of the ectoin and the strontium chloride, and promote the activity of the osteoblast, so that the aims of promoting the repair of the alveolar bone injury, reducing cell injury and inflammatory reaction and preventing tooth sensitivity are fulfilled, and the antibacterial gel has good application value.

Description

Oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride and preparation and application methods thereof

Technical Field

The invention relates to an oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride and a preparation method and a use method thereof.

Background

Common telephone speaking people take food as the day and take teeth as the first, and along with the improvement of the living standard of people, the oral hygiene and the health are also more and more paid attention to. Plaque accumulated in the gingival and dental junction and harmful substances therein act on the gingiva for a long time to cause inflammation, and the presence of plaque, bad restorations, food impaction, tooth dislocation crowding, mouth breathing and the like aggravates plaque accumulation and inflammation of the gingiva to cause gingivitis. If gingivitis is not treated in time, the inflammation can be diffused from the gingiva to the deep layer to periodontal ligament, alveolar bone and cementum to develop into periodontitis, and due to the expansion of the inflammation, the periodontal ligament is destroyed, the alveolar bone is gradually absorbed, the gingiva is separated from the tooth root, so that a gingival sulcus is deepened to form a periodontal pocket, periodontal tissues are destroyed, especially when the absorption of the alveolar bone is aggravated, the supporting tooth strength is insufficient, phenomena such as loosening and displacement of teeth occur, and when the body resistance is reduced and the seepage and drainage of the periodontal pocket are not smooth, periodontal abscess can be formed. In addition, when a patient performs corresponding oral treatment such as scaling, scraping and periodontal surgery, oral bacteria are particularly important in antibacterial care because oral microorganisms widely exist in dental plaque, oral mucosa, dental calculus, gingival pocket, saliva and dental pulp after operation, and easily enter wounds to cause dental plaque and bacterial infection.

At present, the oral care gel products on the market mostly achieve the antibacterial and anti-inflammatory effects by adding antibiotics such as nitroazoles, imidazole derivatives, tetracyclines and the like. For example, the dental implant oral care gel disclosed in Chinese patent document CN110856702A can inhibit dental plaque by adding imidazoline, so as to reduce postoperative infection; another method for synthesizing gel patch preparation for treating periodontitis disclosed in chinese patent document CN111358770a kills porphyromonas gingivalis, praecox intermedia, etc. by adding metronidazole. These methods can effectively kill periodontitis bacteria, but long-term use of the product can easily cause the periodontitis bacteria to generate antibiotic resistance, and can also generate corresponding side effects on human bodies. Moreover, none of these products can repair alveolar bone, which is damaged when periodontal pocket formation occurs as described above, although the existing oral care gel products can kill periodontitis bacteria, however, alveolar bone damage still exists, oral microorganisms widely exist, periodontitis is re-initiated when body resistance is reduced, gingivitis is repeated, and complete healing cannot be achieved.

Disclosure of Invention

Aiming at the problems, the invention provides the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride and the application method thereof, which adopts traditional Chinese medicine components such as honeysuckle extract, pseudo-ginseng extract, baicalin extract and the like to be compatible, and the ectoin and the strontium chloride are added, so that the purposes of antibacterial, anti-inflammatory and repairing alveolar bones and mucous membranes are effectively achieved, drug resistance is not generated, and the oral traditional Chinese medicine antibacterial gel is beneficial to human health. The specific technical scheme is as follows:

firstly, the invention provides an oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride, wherein the effective components of the antibacterial gel comprise baicalin extract, honeysuckle extract, pseudo-ginseng extract, ectoin and strontium chloride.

The oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride comprises the following components in percentage by mass: 1 to 3 percent of ectoin, 1 to 5 percent of strontium chloride, 1 to 5 percent of baicalin extract, 1 to 7 percent of honeysuckle extract, 1 to 5 percent of pseudo-ginseng extract, 0.5 to 1 percent of carbomer and the balance of deionized water.

Preferably, the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride comprises the following components in percentage by mass: the content of the escidodine is preferably 1-2%, the content of the strontium chloride is preferably 1-2%, the content of the baical skullcap root is preferably 2-3%, the content of the honeysuckle is preferably 2-5%, the content of the sanchi is preferably 2-3%, and the content of the carbomer is preferably 0.5-0.7%.

Secondly, the invention provides a preparation method of the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride, which comprises the following steps:

1) Preparing a traditional Chinese medicine extract: preparing baicalin extract, honeysuckle extract and pseudo-ginseng extract according to the requirements respectively for standby;

2) Preparation of an effective component A: weighing the prepared baicalin extract, the honeysuckle extract and the pseudo-ginseng extract according to the weight percentage, and stirring in a proper amount of deionized water until the baicalin extract, the honeysuckle extract and the pseudo-ginseng extract are completely dissolved to obtain an effective component A for later use;

3) Preparation of an effective component B: weighing the ectoin and the strontium chloride according to the weight percentage, and stirring in a proper amount of deionized water until the ectoin and the strontium chloride are completely dissolved to obtain an effective component B for later use;

4) Preparation of carbomer swellings: weighing the carbomer raw material according to the weight percentage, dissolving the carbomer raw material in the balance deionized water, and adding a certain amount of NaOH to adjust the pH to 6-8 to obtain a carbomer swelling material for standby;

5) Preparing antibacterial gel: adding the prepared active component A into the prepared carbomer swelling material, stirring until gel is formed, adding the prepared active component B, and uniformly mixing to obtain the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride.

As a preferred technical scheme, in the preparation method of the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride in step 1), the preparation method of the baicalin extract is as follows: removing fibrous roots and sediment from the dried root of scutellaria baicalensis, removing coarse skin, crushing, scalding the raw materials with 10 times of boiling water for 2 hours after the raw materials are put into a tank, decocting the raw materials with 8 times of water for 1 hour each time respectively for the second and third times, merging decoction, concentrating to a proper amount, regulating the pH value to 1.0-2.0 by using hydrochloric acid, preserving heat at 80 ℃, standing, filtering, precipitating, washing with water to about pH value 5.0, washing with 70% ethanol to about pH value 7.0, drying at low temperature, volatilizing ethanol, and drying under reduced pressure to obtain a baicalin extract finished product.

As a preferred technical scheme, in the preparation method of the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride in step 1), the preparation method of the honeysuckle extract is as follows: cutting dried honeysuckle into segments, firstly using 10 times of water to decoct for 2 hours, filtering, then using 8 times of water to decoct for 2 hours again, filtering, combining filtrate, concentrating under reduced pressure, and drying the concentrated solution under reduced pressure to obtain the honeysuckle extract.

As a preferred technical scheme, in the preparation method of the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride in step 1), the preparation method of the pseudo-ginseng extract is as follows: pulverizing dried root of notoginseng, adding 5-8 times of 70% ethanol, extracting for 2-3 h, collecting filtrate, concentrating under reduced pressure to obtain concentrated solution, and spray drying to obtain notoginseng extract.

As a preferable technical scheme, in the preparation method of the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride, in the step 2), the stirring time for preparing the effective component A is 1-2 h.

As a preferable technical scheme, in the preparation method of the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride, in the step 3), the stirring time for preparing the effective component B is 20-30 min.

In addition, the invention also provides a use method of the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride, which specifically comprises the following steps: injecting the antibacterial gel coating film into a periodontal pocket of a gingival sulcus treatment area after conventional periodontal treatment operation, so that the antibacterial gel coating film wraps teeth until slightly overflows; no food, no water, no mouth rinse within 30 minutes; is used once daily for 7 days as a treatment course.

The beneficial effects of the invention are as follows:

(1) The antibacterial gel disclosed by the invention mainly contains Chinese herbal medicine components, does not contain any antibiotic components, does not cause periodontitis bacteria to generate drug resistance, and has no side effect on human bodies.

(2) According to the antibacterial gel disclosed by the invention, the addition of the ectoin and the strontium chloride can promote the repair of alveolar bone injury, wherein the ectoin can form a protective layer around cells, so that the cell injury is effectively reduced, osteoblasts are protected, the strontium chloride can promote the activity of the osteoblasts, the proliferation of the osteoblasts is increased, and under the synergistic effect of the ectoin and the strontium chloride, the activity of the osteoblasts is promoted while the injury of the osteoblasts is reduced, so that the purposes of promoting the repair of the alveolar bone injury, reducing the cell injury and inflammatory response and preventing tooth sensitivity are achieved.

(3) The antibacterial gel disclosed by the invention has the effects of inhibiting bacteria and diminishing inflammation and preventing and treating swelling and pain after being treated by adding the baicalin extract and the honeysuckle extract; the pseudo-ginseng extract is added to help the gum to stop bleeding and accelerate the healing of mucous membrane; the combination of the ectoin and the strontium chloride promotes the injury repair effect of the alveolar bone, achieves the purpose of one-step treatment and repair, and solves the problem that periodontitis is repeatedly difficult to cure.

(4) The preparation method of the antibacterial gel of the invention concentrates the baicalin extract to improve the antibacterial effect; the concentrated solution of the honeysuckle extract is decompressed and dried, so that pharmacological active ingredients such as chlorogenic acid, luteolin glycoside and the like of the concentrated solution are reserved to the maximum extent, and the inhibition of the concentrated solution on periodontitis bacteria is ensured; the concentrated solution of the pseudo-ginseng extract adopts spray drying to ensure the activity of components such as saponins, polysaccharides, flavonoids, alkynes, alcohols and the like, and ensure that the components can induce platelets to release hemostatic active substances such as ADP, platelet factors, ca2+, and the like, and promote only coagulation and oral mucosa repair.

(5) According to the preparation method of the antibacterial gel, the ectoine, the strontium chloride, the honeysuckle extract, the pseudo-ginseng extract and the baicalin extract are prepared separately and then sequentially added into the carbomer swelling material, so that the problem that the effective components cannot be uniformly dispersed and dissolved due to the fact that the strontium salt reacts with flavonoid and other components in the honeysuckle extract, the pseudo-ginseng extract and the baicalin extract and the effective components are directly mixed with the carbomer is effectively avoided.

(6) The antibacterial gel prepared by the invention has wide application range, and can be suitable for antibacterial and anti-inflammatory treatment of corresponding oral cavity treatments such as cleaning, scraping treatment, periodontal surgery and the like, and can also be suitable for relieving the problem of tooth sensitivity after tooth washing, tooth whitening and the like.

Drawings

FIG. 1 shows the indexes of the antibacterial gel before administration;

FIG. 2 shows the indexes observed 3 days after the antibacterial gel is used for medicine;

fig. 3 shows the indexes observed 7 days after administration of the antibacterial gel.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the embodiments.

Example 1

The embodiment is to prepare an oral traditional Chinese medicine antibacterial gel containing ectoine and strontium chloride, wherein the antibacterial gel comprises the following components in percentage by mass: 3% of ectoin, 4% of strontium chloride, 2% of baicalin extract, 2% of honeysuckle extract, 1% of pseudo-ginseng extract, 1% of carbomer and the balance of deionized water. The preparation method comprises the following specific steps:

1) Preparing a traditional Chinese medicine extract: preparing baicalin extract, flos Lonicerae extract and Notoginseng radix extract respectively according to requirements. Wherein,,

the preparation method of the baicalin extract comprises the following steps: removing fibrous roots and sediment from the dried root of scutellaria baicalensis, removing coarse skin, crushing, scalding the raw materials with 10 times of boiling water for 2 hours after the raw materials are put into a tank, decocting the raw materials with 8 times of water for 1 hour each time respectively for the second and third times, merging decoction, concentrating to a proper amount, regulating the pH value to 1.0-2.0 by using hydrochloric acid, preserving heat at 80 ℃, standing, filtering, precipitating, washing with water to about pH value 5.0, washing with 70% ethanol to about pH value 7.0, drying at low temperature, volatilizing ethanol, and drying under reduced pressure to obtain a baicalin extract finished product.

The preparation method of the honeysuckle extract comprises the following steps: cutting dried honeysuckle into segments, firstly using 10 times of water to decoct for 2 hours, filtering, then using 8 times of water to decoct for 2 hours again, filtering, combining filtrate, concentrating under reduced pressure, and drying the concentrated solution under reduced pressure to obtain the honeysuckle extract.

The preparation method of the pseudo-ginseng extract comprises the following steps: pulverizing dried root of notoginseng, adding 5-8 times of 70% ethanol, extracting for 2-3 h, collecting filtrate, concentrating under reduced pressure to obtain concentrated solution, and spray drying to obtain notoginseng extract.

2) Preparation of an effective component A: the baicalin extract, the honeysuckle extract and the pseudo-ginseng extract which are prepared by weighing according to the weight percentage are dissolved in a proper amount of deionized water and stirred for 1-2 hours until the baicalin extract, the honeysuckle extract and the pseudo-ginseng extract are completely dissolved, and an effective component A is obtained for standby.

3) Preparation of an effective component B: weighing the ectoin and the strontium chloride according to the weight percentage, dissolving the ectoin and the strontium chloride in a proper amount of deionized water, and stirring for 20-30 min until the ectoin and the strontium chloride are completely dissolved, thus obtaining an effective component B for standby.

4) Preparation of carbomer swellings: and weighing the carbomer raw materials according to the weight percentage, dissolving the carbomer raw materials in the rest deionized water, taking the condition that white powder cannot be seen on the surface and white aggregate cannot be seen in the solution as a reference, and adding a certain amount of NaOH to adjust the pH to 6-8 to obtain the carbomer swelled material for standby.

Example 2

The embodiment also prepares a traditional Chinese medicine antibacterial gel for oral cavity containing ectoin and strontium chloride, and the antibacterial gel comprises the following components in percentage by mass: 2% of ectoin, 2% of strontium chloride, 3% of baicalin, 5% of honeysuckle extract, 3% of pseudo-ginseng extract, 0.7% of carbomer and the balance of deionized water. The specific preparation method is the same as in example 1.

Example 3

The embodiment also prepares a traditional Chinese medicine antibacterial gel for oral cavity containing ectoin and strontium chloride, and the antibacterial gel comprises the following components in percentage by mass: 1% of ectoine, 1% of strontium chloride, 5% of baicalin, 7% of honeysuckle extract, 5% of pseudo-ginseng extract, 0.5% of carbomer and the balance of deionized water. The specific preparation method is the same as in example 1.

Effect example

In order to verify the synergistic effect of the ectoin and the strontium chloride to promote the repair of alveolar bone injury, and the effects of inhibiting bacteria, diminishing inflammation, helping to stop bleeding of gums and accelerating healing of mucous membranes of the traditional Chinese medicine extract components. The embodiment adopts a comparative example mode for verification, and the specific verification method is as follows:

first, this example provides three sets of comparative examples, and provides a blank, wherein:

comparative example 1: the prepared antibacterial gel for oral cavity traditional Chinese medicine comprises the following components in percentage by mass: 2% of baicalin, 2% of honeysuckle extract, 1% of pseudo-ginseng extract, 1% of carbomer and the balance of deionized water. The specific preparation method is the same as in example 1.

Comparative example 2: the prepared antibacterial gel for oral cavity traditional Chinese medicine comprises the following components in percentage by mass: strontium chloride 4%, baicalin 2%, honeysuckle extract 2%, pseudo-ginseng extract 1%, carbomer 1% and the balance of deionized water. The specific preparation method is the same as in example 1.

Comparative example 3: the prepared antibacterial gel for oral cavity traditional Chinese medicine comprises the following components in percentage by mass: 3% of ectoin, 2% of baicalin, 2% of honeysuckle extract, 1% of pseudo-ginseng extract, 1% of carbomer and the balance of deionized water. The specific preparation method is the same as in example 1.

The components and the contents of the oral traditional Chinese medicine antibacterial gel prepared in each comparative example, comparative example and example are shown in table 1.

TABLE 1 oral antibacterial gel products for each group

Component (A)

Blank control group

Comparative example 1

Comparative example 2

Comparative example 3

Example 1

Example 2

Example 3

Ikeduoyin

0

--

3％

2％

1％

Strontium chloride

0

--

4％

--

4％

2％

1％

Baicalin extract

0

2％

3％

5％

Honeysuckle extract

0

2％

7％

Notoginseng radix extract

0

1％

5％

Carbomer (carbomer)

0

1％

0.7％

0.5％

Deionized water

0

94％

90％

91％

87％

80.3％

80.5％

Physiological saline

100％

0

The experimental method comprises the following steps: in order to ensure the true effectiveness of the effect, 140 adult periodontitis patients are selected as study objects in the experiment, and the ages of the patients are as follows: the animals were 18-60 years old and were equally divided into experimental, control and blank groups at random. The blank control group is used for conventional periodontal cleaning and scraping treatment, and is washed by conventional normal saline after operation. The experimental group carried out conventional periodontal scaling and scraping treatment, and the oral antibacterial gel product prepared in examples 1-3 was used after operation, and the coating film was injected into gingival sulcus and periodontal pocket in the treatment area to wrap the teeth until slightly overflowing. No food, no water, no mouth rinse within 30 minutes. Is used once daily. The comparative group was treated in exactly the same manner as the experimental group except that the oral antibacterial gel products prepared in comparative examples 1 to 3 were used. The component contents of the oral antibacterial gel products used in each group are shown in table 1. The Gingival Index (GI), plaque index (PLI), gingival crevicular bleeding index (SBI) and depth of investigation (PD) were observed and counted for the patient before treatment, 3 days after treatment, and 7 days after treatment, respectively.

Experimental results: the two groups of observations before and after the treatment are shown in tables 2, 3 and 4 and figures 1 to 3.

TABLE 2 observation index before administration

Index (I)

Blank control group

Control group 1

Control group 2

Control group 3

Experiment group 1

Experiment group 2

Experiment group 3

GI

1.93±0.27

1.92±0.35

1.93±0.24

1.95±0.37

1.95±0.55

1.92±0.53

1.95±0.52

PLI

2.11±0.15

2.08±0.29

2.10±0.11

2.05±0.20

2.02±0.31

2.06±0.37

2.10±0.11

SBI

3.08±0.30

3.14±0.25

3.20±0.35

3.05±0.31

3.17±0.47

3.29±0.37

3.10±0.35

PD

5.01±0.97

4.95±0.86

5.13±0.62

4.96±0.59

4.98±1.01

5.03±0.88

4.98±0.92

TABLE 3 observation index 3 days after administration

Index (I)

Blank control group

Control group 1

Control group 2

Control group 3

Experiment group 1

Experiment group 2

Experiment group 3

GI

1.61±0.39

1.12±0.33

1.09±0.52

1.11±0.38

1.02±0.34

1.12±0.55

1.05±0.39

PLI

1.76±0.39

1.25±0.31

1.17±0.35

1.20±0.36

1.13±0.19

1.16±0.42

1.10±0.53

SBI

1.97±0.51

1.44±0.35

1.41±0.40

1.45±0.53

1.40±0.36

1.42±0.34

1.46±0.38

PD

4.62±0.93

4.65±0.71

4.50±0.51

4.54±0.50

4.33±0.91

4.35±0.70

4.38±0.62

TABLE 4 observation index 7 days after administration

Index (I)

Blank control group

Control group 1

Control group 2

Control group 3

Experiment group 1

Experiment group 2

Experiment group 3

GI

0.98±0.62

0.65±0.37

0.58±0.21

0.62±0.35

0.53±0.52

0.59±0.41

0.65±0.48

PLI

1.13±0.39

0.88±0.26

0.84±0.31

0.85±0.20

0.79±0.28

0.86±0.33

0.83±0.42

SBI

0.70±0.48

0.31±0.29

0.27±0.33

0.30±0.51

0.28±0.29

0.31±0.54

0.30±0.41

PD

4.31±0.90

4.32±0.53

4.10±0.71

4.16±0.64

3.87±0.89

3.90±0.58

3.88±0.67

Each observation index of the experimental group and the control group is processed by SPSS software, and is statistically processed by t test, and the comparison of the two groups has significant difference P less than 0.05. The test result shows that the antibacterial gel for oral cavity can obtain better clinical effect when being applied to adjuvant therapy of periodontitis, and can effectively inhibit bacteria, diminish inflammation and stop bleeding and recover.

Meanwhile, fig. 1 to 3 also show that the index of the control group GI, PLI, SBI is obviously better than that of the control group compared with the recovery condition of the control group before and after the administration for 3 days, so that the traditional Chinese medicine extract components in the antibacterial gel for oral cavity can achieve the effects of inhibiting bacteria, diminishing inflammation, helping gum hemostasis and accelerating mucous membrane healing. The PD index of the experimental group is smaller than that of the control group by comparing the recovery condition of the control group and the experimental group before and after the administration for 7 days, which shows that the repairing of the alveolar bone injury can be promoted to a certain extent under the synergistic effect of the ectoin and the strontium chloride.

In general, the antibacterial gel disclosed by the invention mainly contains Chinese herbal medicine components, does not contain any antibiotic components, does not cause periodontitis bacteria to generate drug resistance, and has no side effect on human bodies. According to the antibacterial gel disclosed by the invention, the addition of the ectoin and the strontium chloride can promote the repair of alveolar bone injury, wherein the ectoin can form a protective layer around cells, so that the cell injury is effectively reduced, osteoblasts are protected, the strontium chloride can promote the activity of the osteoblasts, the proliferation of the osteoblasts is increased, and under the synergistic effect of the ectoin and the strontium chloride, the activity of the osteoblasts is promoted while the injury of the osteoblasts is reduced, so that the purposes of promoting the repair of the alveolar bone injury, reducing the cell injury and inflammatory response and preventing tooth sensitivity are achieved. The antibacterial gel disclosed by the invention has the effects of inhibiting bacteria and diminishing inflammation and preventing and treating swelling and pain after being treated by adding the baicalin extract and the honeysuckle extract; the pseudo-ginseng extract is added to help the gum to stop bleeding and accelerate the healing of mucous membrane; the combination of the ectoin and the strontium chloride promotes the injury repair effect of the alveolar bone, achieves the purpose of one-step treatment and repair, and solves the problem that periodontitis is repeatedly difficult to cure. The preparation method of the antibacterial gel of the invention concentrates the baicalin extract to improve the antibacterial effect; the concentrated solution of the honeysuckle extract is decompressed and dried, so that pharmacological active ingredients such as chlorogenic acid, luteolin glycoside and the like of the concentrated solution are reserved to the maximum extent, and the inhibition of the concentrated solution on periodontitis bacteria is ensured; the concentrated solution of the pseudo-ginseng extract adopts spray drying to ensure the activity of components such as saponins, polysaccharides, flavonoids, alkynes, alcohols and the like, ensure that platelets can be induced to release hemostatic active substances such as ADP, platelet factors, ca2+, and the like, and promote blood coagulation and oral mucosa repair. According to the preparation method of the antibacterial gel, the ectoine, the strontium chloride, the honeysuckle extract, the pseudo-ginseng extract and the baicalin extract are prepared separately and then sequentially added into the carbomer swelling material, so that the problem that the effective components cannot be uniformly dispersed and dissolved due to the fact that the strontium salt reacts with flavonoid and other components in the honeysuckle extract, the pseudo-ginseng extract and the baicalin extract and the effective components are directly mixed with the carbomer is effectively avoided. The antibacterial gel prepared by the invention has wide application range, can be suitable for antibacterial and anti-inflammatory treatment of corresponding oral cavity such as cleaning, scraping and periodontal surgery, can also be suitable for relieving the problem of tooth sensitivity after tooth washing and tooth whitening, and has good application value.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. Accordingly, the embodiments are to be considered in all respects as illustrative and not restrictive. Furthermore, it should be understood that, although the present disclosure describes embodiments, this description is not intended to include only one embodiment, and those skilled in the art should understand that the present disclosure is not limited to the embodiments described herein, and that the embodiments described in the examples may be combined appropriately to form other embodiments that will be understood by those skilled in the art.

Claims

1. An oral traditional Chinese medicine antibacterial gel containing ectoin and strontium chloride is characterized in that: the active ingredients of the antibacterial gel comprise baicalin extract, honeysuckle extract, pseudo-ginseng extract, ectoin and strontium chloride; wherein:

the preparation method of the honeysuckle extract comprises the following steps: cutting dried honeysuckle into segments, firstly decocting with 10 times of water for 2 hours, filtering, then decocting with 8 times of water for 2 hours again, filtering, combining filtrates, concentrating under reduced pressure, and drying the concentrate under reduced pressure to obtain a honeysuckle extract;

2. The antibacterial gel for oral cavity containing ectoin and strontium chloride according to claim 1, wherein the antibacterial gel is characterized in that: the antibacterial gel comprises the following components in percentage by mass: 1 to 3 percent of ectoin, 1 to 5 percent of strontium chloride, 1 to 5 percent of baicalin extract, 1 to 7 percent of honeysuckle extract, 1 to 5 percent of pseudo-ginseng extract, 0.5 to 1 percent of carbomer and the balance of deionized water.

3. The antibacterial gel for oral use containing exendin and strontium chloride according to claim 2, wherein: the antibacterial gel comprises the following components in percentage by mass: 1-2% of ectoin, 1-2% of strontium chloride, 2-3% of baicalin extract, 2-5% of honeysuckle extract, 2-3% of pseudo-ginseng extract and 0.5-0.7% of carbomer.

4. A method for preparing the antibacterial gel containing the exendin and the strontium chloride for oral use according to claim 2 or 3, which is characterized in that: the method comprises the following steps:

4) Preparation of carbomer swellings: weighing the carbomer raw material according to the weight percentage, dissolving the carbomer raw material in the balance deionized water, and adding a certain amount of NaOH to adjust the pH to 6-8 to obtain a carbomer swelling material for later use;

5. The method for preparing the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride, which is disclosed in claim 4, is characterized in that: in the step 1), the preparation method of the baicalin extract comprises the following steps: removing fibrous roots and sediment from the dried root of scutellaria baicalensis, removing coarse skin, crushing, scalding the raw materials with 10 times of boiling water for 2 hours after the raw materials are put into a tank, decocting the raw materials with 8 times of water for 1 hour each time respectively for the second and third times, merging decoction, concentrating to a proper amount, regulating the pH value to 1.0-2.0 by using hydrochloric acid, preserving heat at 80 ℃, standing, filtering, precipitating, washing with water to about pH value 5.0, washing with 70% ethanol to about pH value 7.0, drying at low temperature, volatilizing ethanol, and drying under reduced pressure to obtain a baicalin extract finished product.

6. The method for preparing the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride, which is disclosed in claim 4, is characterized in that: in the step 2), the stirring time for preparing the effective component A is 1-2 h.

7. The method for preparing the oral traditional Chinese medicine antibacterial gel containing the ectoin and the strontium chloride, which is disclosed in claim 4, is characterized in that: in the step 3), the stirring time for preparing the effective component B is 20-30 min.

8. Use of an oral traditional Chinese medicine antibacterial gel containing ectoine and strontium chloride according to any one of claims 1-3 for preparing a medicament, characterized in that: the using method comprises the following steps: injecting the antibacterial gel coating film into a periodontal pocket of a gingival sulcus treatment area after conventional periodontal treatment operation, so that the antibacterial gel coating film wraps teeth until slightly overflows; no food, no water, no mouth rinse within 30 minutes; is used once daily for 7 days as a treatment course.