CN114010164A

CN114010164A - Intracranial multi-parameter monitoring system based on sensor

Info

Publication number: CN114010164A
Application number: CN202111076980.XA
Authority: CN
Inventors: 谢志远; 潘海; 沈鹏冰
Original assignee: Guangzhou Fengding Medical Technology Co ltd
Current assignee: Guangzhou Fengding Medical Technology Co ltd
Priority date: 2021-09-14
Filing date: 2021-09-14
Publication date: 2022-02-08

Abstract

The invention discloses an intracranial multiparameter monitoring system based on a sensor, which comprises an intracranial probe, an independent monitoring host unit and intracranial multiparameter monitoring software developed for the system, wherein the intracranial probe integrates an intracranial pressure probe and an intracranial temperature probe, the intracranial probe is electrically connected with the independent monitoring host unit through a data line and uploads collected data to the independent monitoring host, the independent monitoring host is provided with the intracranial multiparameter monitoring software and can realize the accurate measurement of five intracranial pressure parameters of a single patient, and the intracranial multiparameter monitoring software comprises a starting module, a sensor data analysis and operation module, a digital zero setting module, an alarm module, an emWin display module, a serial communication module, a key processing module and a power management module. The invention realizes the monitoring of invasive arterial pressure IBP, intracranial pressure ICP and intracranial temperature ICT through a multi-sensor, realizes the real-time monitoring of mean arterial pressure MAP and cerebral perfusion pressure CPP through an algorithm, and simultaneously realizes the dynamic monitoring of five parameters.

Description

Intracranial multi-parameter monitoring system based on sensor

Technical Field

The invention relates to the technical field of diagnosis and treatment auxiliary equipment, in particular to an intracranial multi-parameter monitoring system based on a sensor.

Background

The intracranial pressure ICP is an important observation index for neurosurgical clinic and scientific research, and the increase of the intracranial pressure can cause the rapid changes of vital signs such as headache, vomit, fundus oculi lesion, convulsion, peripheral nerve paralysis, disturbance of consciousness, pupil change, pulmonary edema, blood pressure, heart rate, respiration and the like. Cerebral perfusion pressure CPP and intracranial temperature ICT are two other important monitoring indicators for neurosurgical patients, and the cerebral perfusion pressure CPP is mean arterial pressure MAP-intracranial pressure ICP, and is normally used as an adult CPP: 60mmHg (50-70mm Hg), the mean arterial pressure MAP is the mean value of the invasive arterial pressure IBP, the rise of the intracranial temperature ICT is closely related to the rise of the intracranial pressure ICP, the intracranial pressure ICP rises by 5.5 percent when the intracranial temperature ICT rises by one degree centigrade, the change of the intracranial temperature ICT is earlier than the change of the intracranial pressure ICP, and the condition of a patient can be predicted in advance by monitoring the intracranial temperature ICT.

Among the prior art, the intracranial pressure monitoring system of domestic use is mostly single parameter intracranial pressure monitor or contains the double parameter intracranial pressure monitor of monitoring intracranial temperature, and the function is more single, can't realize that many parameters such as brain perfusion pressure CPP are monitored synthetically, for this reason, we propose a intracranial many parameter monitoring system based on sensor, monitor a plurality of parameters simultaneously.

Disclosure of Invention

The technical problem to be solved by the invention is to overcome the existing defects and provide an intracranial multiparameter monitoring system based on sensors, invasive arterial pressure IBP, intracranial pressure ICP and intracranial temperature ICT are monitored by the multisensor, real-time monitoring of average arterial pressure MAP and cerebral perfusion pressure CPP is realized by an algorithm, dynamic monitoring of five parameters is realized, and the problems in the background technology can be effectively solved.

In order to achieve the purpose, the invention provides the following technical scheme: the intracranial multiparameter monitoring software comprises a starting module, a sensor data analysis and operation module, a digital zero-setting module, an alarm module, an emWin display module, a serial communication module, a key processing module and a power management module, wherein all the modules distribute priorities according to real-time requirements, an execution period, an importance degree and MCU time.

Furthermore, the intracranial probe comprises a probe end, a probe tube body and a connector end, the probe end comprises an intracranial pressure sensor and a temperature sensor, an analog-to-digital converter for processing signal conversion, an MCU1 for processing data and a storage unit for storing data are arranged in the connector end, the connector end also comprises a sensor interface circuit, an interaction module, a serial port signal conversion module circuit and a wake-up circuit, the intracranial pressure sensor detects the intracranial pressure ICP, the temperature sensor is used for acquiring the temperature of a position to be detected, such as a ventricle or subdural, and the like, namely the intracranial temperature ICT, the sensor interface circuit is used for reading signals obtained by the measurement of the two sensors, the interaction module, the serial port signal conversion module circuit controls the collection, processing, packaging and storage of sensor data in the whole system, a circuit in the intracranial probe is in a dormant state before the circuit formally starts to work, and the circuit needs to be awakened when the circuit formally starts to work.

Furthermore, the intracranial pressure sensor is a miniature pressure sensor adopting a half-bridge structure of a classic Wheatstone bridge, is connected with an external bridge matching unit through a bonding wire to form a Wheatstone full bridge, converts a pressure signal into a differential voltage signal, converts an analog signal into a digital signal through an analog-to-digital converter after differential amplification of a differential amplification circuit, and automatically calibrates through a self-calibration circuit.

Furthermore, the miniature pressure sensor comprises two piezoresistors R3 and R4, when the miniature pressure sensor is pressed, the resistance value of the piezoresistor R3 is increased, the resistance value of the R4 is reduced, the balance condition of the Wheatstone bridge is not met, and differential voltage is generated between the point A and the point B; in an external half-bridge circuit of the bridge matching unit, R5, R6 and R7 are connected in parallel and then connected in series with a slide rheostat R1, the bridge matching unit is equivalent to an adjustable resistor R1 in the half-bridge circuit of a Wheatstone bridge, R8, R9 and R10 are connected in parallel and then connected in series with the slide rheostat R2,

numbers

1, 2, 3, 4 and 5 in the adjustable resistor R2 and P2 in the half-bridge circuit of the Wheatstone bridge are equivalent to five independent bonding pads, after a micro pressure sensor bonding pad in an intracranial pressure probe is led out by using three enameled wires, then the enameled wires are welded on the

P2 bonding pads

2, 3 and 4 to complete the matching of the Wheatstone bridge, after the bonding pad of the miniature temperature sensor in the probe is led out by using two enameled wires, and then the enameled wires are welded on the P2 bonding pads 1 and 5, the PreIN + and the PreIN-are equivalent to the point A and the point B, and the TempR + and the TempR-are connected with a subsequent voltage division circuit and used for collecting temperature signals.

Furthermore, the independent monitoring host unit comprises a power management module for power supply management, a storage module for data storage, an interaction module for human-computer interaction, a serial port signal conversion module for communication with the signal acquisition unit and an external network, an MCU2 core board module for managing other components, and an alarm module for sending an alarm signal when abnormality occurs.

Furthermore, the power management module comprises a USB power supply module, an adapter power supply module and a battery power supply module, and provides power supply for the independent monitoring host unit in multiple modes, wherein the adapter is used for supplying power to the host during long-term bedside monitoring, the battery is used for supplying power to the monitoring host in a short time when a patient is moved, and the USB interface is used for data export and also can supply power to the monitoring host; the storage module is used for recording the time for monitoring the intracranial pressure ICP and the intracranial temperature ICT of the patient and recording data, and guiding medical care personnel to judge the condition of the patient and take medicine; the interaction module comprises a TFT-LCD and a key, and a user finishes the operation of the host unit by using the key and the TFT-LCD, wherein the operation comprises menu setting, alarm threshold setting, time setting and zero clearing confirmation, the intracranial pressure ICP, the cranial temperature ICT, the invasive arterial pressure IBP, the mean arterial pressure MAP are displayed by numerical values, and the intracranial pressure ICP and the cerebral perfusion pressure CPP are displayed by waveforms; the serial port communication module is used for communicating with the MCU1 in the intracranial probe; the alarm module comprises a TFT-LCD, an LED and a buzzer and provides sound and light signal alarm, the sound signal alarm is realized by outputting different frequencies of sound by the MCU2 to control the buzzer through PWM waves, the light signal alarm is realized by outputting different frequencies of flashing light by the MCU2 to control the LED, and the TFT-LCD realizes the light signal alarm by popping up an alarm dialog box, changing font colors, flashing numbers and the like.

Furthermore, the sensor-based intracranial multiparameter monitoring system further comprises a mean arterial pressure Monitor (MAP), wherein the mean arterial pressure Monitor (MAP) is monitored through an invasive arterial pressure sensor, and the invasive arterial pressure sensor is electrically connected with the independent monitoring host unit through a data line.

Further, the start module completes MCU2 hardware initialization, μ C/OS-III initialization, software timer, semaphore and event flag group creation and creation of other all modules on μ C/OS-III kernel, the start module calls OSTaskDel function to delete itself at last, and the start module only runs once; the sensor data analysis and operation module collects an invasive arterial pressure IBP measured by an invasive arterial pressure sensor, an intracranial pressure ICP measured by an intracranial pressure sensor and a cranial temperature ICT measured by a temperature sensor placed in the cranium, then the average arterial pressure MAP is (IBPas + IBPad)/2, the IBPas is invasive arterial systolic pressure, the IBPad is invasive arterial diastolic pressure to calculate the average arterial pressure MAP, and the cerebral perfusion pressure CPP is calculated according to the cerebral perfusion pressure which is the average arterial pressure-the intracranial pressure, namely the MAP-ICP is CPP. The monitoring of three sensors is realized to display five parameters of intracranial pressure ICP, invasive arterial pressure IBP, cerebral perfusion pressure CPP, mean arterial blood pressure MAP and intracranial temperature ICT; the digital zero setting module is used for realizing zero setting of the intracranial pressure sensor, the temperature sensor and the invasive arterial pressure sensor, the intracranial pressure sensor, the temperature sensor and the invasive arterial pressure sensor are internally provided with storage modules, data such as zero point information, implantation time, patient information and the like are directly recorded, and each sensor is specifically corresponding to a corresponding patient; the alarm module uses an event mark group in the mu C/OS-III to represent alarm states of different types, overpressure alarm, error alarm of a calibration parameter of a reading probe, overdue alarm of the use of the probe and low-power alarm are represented by different mark bits in the event mark group, and the alarm module carries out 'setting' and 'zero clearing' treatment on different mark bits in the event mark group according to the alarm types sent by other modules to finish alarm of different types; the emWin display module completes the numerical value display of the intracranial pressure ICP and the cranial temperature ICT, the waveform display of the intracranial pressure ICP and the cerebral perfusion pressure CPP and the time refreshing, the display module receives window messages sent by other modules, calls a GUI _ Delay function to refresh a screen area at regular time, completes interface interaction, and sets the emWin display module to be in lower priority in order to avoid influencing the operation of a module with higher real-time requirement; the serial port communication module completes the communication between the MCU2 and the MCU1 in the intracranial probe; the key processing module completes the response to the key operation of the user, and sets the higher priority of the key processing module in order to avoid overlong key response time; the electric quantity scanning module completes battery electric quantity monitoring, reminds a guardian to connect the power adapter to the monitoring host in time when the battery power supply is not enough, and prevents the equipment from being powered off suddenly.

Furthermore, the intracranial probe is implanted into the brain of a patient in a bolt-type or tunnel-type embedding mode, and the implantation position can be brain parenchyma or a brain ventricle.

Compared with the prior art, the invention has the beneficial effects that: the intracranial multi-parameter monitoring system based on the sensor has the following advantages:

1. the invention realizes the dynamic real-time monitoring of five parameters of the patient such as the intracranial pressure ICP, the invasive arterial pressure IBP, the cerebral perfusion pressure CPP, the mean arterial blood pressure MAP and the intracranial temperature ICT through the multi-sensor, and the physical condition of the patient can be known in time.

2. The monitoring host unit is provided with a zero clearing key, a menu key, an upward selection key, a downward selection key and an alarm silencing key, and the real-time response requirements of operations such as setting an alarm threshold value, clearing and the like on the keys are high. Meanwhile, the software has high real-time performance required by functions such as data display, waveform display, data receiving and reporting and the like of ICP and the like.

3. The monitoring process needs to give an alarm for the abnormal values of ICP and ICT of the patient and the abnormal state of the monitoring host unit, such as: overpressure alarm, error alarm of reading calibration parameters of the probe, overdue alarm of using the probe and low-power alarm.

4. The method is suitable for measuring intracranial pressure and intracranial temperature of a patient, and is suitable for patients with traumatic brain injury accompanied by coma (Grassner coma score is between 3 and 8) and abnormal CT scanning, and patients with traumatic brain injury accompanied by coma and normal CT scanning but at least risk factors (more than two items of 40 years old, motor dysfunction and systolic pressure less than 90 mmHg).

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a circuit diagram of a Wheatstone bridge according to an embodiment of the invention;

FIG. 3 is a circuit diagram of a bridge matching unit according to the present invention;

FIG. 4 is a flow chart of signal processing of an intracranial pressure sensor in the present invention;

FIG. 5 is an architecture diagram of the independent monitoring host unit of the present invention;

FIG. 6 is a diagram showing the structure of the intracranial multiparameter monitoring software according to the present invention.

In the figure: the probe end 1, the probe tube body 2, the interface end 3 and the invasive arterial pressure sensor 4.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example one

Referring to fig. 1-6, the present embodiment provides a technical solution: as shown in figures 1 and 6, a sensor-based intracranial multiparameter monitoring system comprises an intracranial probe, an independent monitoring host unit and intracranial multiparameter monitoring software developed for the system, wherein the intracranial probe integrates an intracranial pressure probe and an intracranial temperature probe, the intracranial probe is electrically connected with the independent monitoring host unit through a data line and uploads collected data to the independent monitoring host, the independent monitoring host is provided with the intracranial multiparameter monitoring software, accurate measurement of five parameters of the intracranial pressure of a single patient can be realized, the intracranial multiparameter monitoring software comprises a starting module, a sensor data analysis and operation module, a digital zero-setting module and an alarm module, the system comprises an emWin display module, a serial port communication module, a key processing module and a power management module, wherein all the modules distribute priorities according to real-time requirements, execution cycles, importance degrees and MCU (microprogrammed control unit) occupied time.

As shown in fig. 1, the intracranial probe comprises a probe end 1, a probe tube body 2 and an interface end 3, the probe end 1 comprises an intracranial pressure sensor and a temperature sensor, an analog-to-digital converter for processing signal conversion, an MCU1 for processing data and a storage unit for storing data are arranged in the interface end 3, the interface end 3 further comprises a sensor interface circuit, an interaction module, a serial signal conversion module circuit and a wake-up circuit, the intracranial pressure sensor detects intracranial pressure ICP, the temperature sensor is used for acquiring the temperature of a place to be measured, such as ventricle or subdural, i.e. intracranial temperature ICT, the sensor interface circuit is used for reading signals measured by the two sensors, the interaction module and the serial signal conversion module circuit control the acquisition, processing, packaging and storage of sensor data in the whole system, the circuit in the intracranial probe is in a dormant state before the circuit is formally started to work, when the circuit formally starts to work, the circuit needs to be awakened.

The intracranial pressure sensor is a miniature pressure sensor adopting a half-bridge structure of a classic Wheatstone bridge, forms a Wheatstone full bridge with an external resistor network, converts pressure signals into differential voltage signals, converts analog signals into digital signals by using an analog-to-digital converter after differential amplification of a differential amplification circuit, and automatically calibrates through a self-calibration circuit.

As shown in fig. 2 and 3, the miniature pressure sensor comprises two piezoresistors R3 and R4, when the miniature pressure sensor is pressed, the resistance value of the piezoresistor R3 is increased, the resistance value of the piezoresistor R4 is decreased, the balance condition of the wheatstone bridge is not established, and a differential voltage is generated between the point a and the point B; in an external half-bridge circuit of the bridge matching unit, R5, R6 and R7 are connected in parallel and then connected in series with a slide rheostat R1, the bridge matching unit is equivalent to an adjustable resistor R1 in the half-bridge circuit of a Wheatstone bridge, R8, R9 and R10 are connected in parallel and then connected in series with the slide rheostat R2, the bridge matching unit is equivalent to an adjustable resistor R2 in the half-bridge circuit of the Wheatstone bridge,

numbers

1, 2, 3, 4 and 5 in P2 correspond to five independent bonding pads, a miniature pressure sensor bonding pad in an intracranial pressure probe is led out by using three enameled wires, and then the enameled wires are welded on the

bonding pads

2, 3 and 4 of the P2, so that matching of the Wheatstone bridge is completed; after the miniature temperature sensor bonding pad in the probe is led out by using two enameled wires, the enameled wires are welded on the P2 bonding pads 1 and 5, the PreIN + and the PreIN-are equivalent to the point A and the point B, and the TempR + and the TempR-are connected with a subsequent voltage division circuit and used for collecting temperature signals.

As shown in fig. 4, the signal processing flow of the intracranial pressure sensor is as follows: radio frequency signals containing measured intracranial pressure data information are mixed to zero intermediate frequency after passing through a low noise amplifier LNA, the intermediate frequency signals are amplified through a two-stage variable gain amplifier PGA and then enter two paths of analog-to-digital converters ADC, the signals are quantized into I, Q two paths of digital signals, then a digital baseband processes the I, Q two paths of signals, the radio frequency modulation mode adopted by a data transmitting end is MSK (minimum frequency shift keying) modulation, so that a demodulator in an intracranial pressure probe is an MSK demodulator, the signals are demodulated, channel decoded and unpacked, the unpacked intracranial pressure data and the temperature data under the scalp are directly transmitted to an independent monitoring host unit through a USB interface by a USB controller, and the independent monitoring host unit displays and stores and manages the data in real time.

Example two

The difference between the present embodiment and the first embodiment is:

in this embodiment, as shown in fig. 5, the independent monitoring host unit includes a power management module for power supply management, a storage module for storing data, an interaction module for human-computer interaction, a serial port signal conversion module for communicating with the signal acquisition unit and an external network, an MCU2 core board module for managing other components, and an alarm module for sending an alarm signal when an abnormality occurs.

The power management module comprises a USB power supply module, an adapter power supply module and a battery power supply module, and provides power for the independent monitoring host unit in multiple modes, the adapter is used for supplying power to the host during long-term bedside monitoring, the battery is used for supplying power to the monitoring host in a short time when a patient is moved, and the USB interface is used for data export and also can supply power to the monitoring host; the storage module is used for recording the time for monitoring the intracranial pressure ICP and the intracranial temperature ICT of the patient and recording data, and guiding medical care personnel to judge the condition of the patient and take medicine; the interaction module comprises a TFT-LCD and a key, a user finishes the operation of the host unit by using the key and the TFT-LCD, the operation comprises menu setting, alarm threshold setting, time setting and zero clearing confirmation, and the TFT-LCD is used for displaying the numerical values of the intracranial pressure ICP and the intracranial temperature ICT and displaying the waveforms of the intracranial pressure ICP and the cerebral perfusion pressure CPP; the serial port communication module is used for communicating with the intracranial probe; the alarm module comprises a TFT-LCD, an LED and a buzzer and provides sound and light signal alarm, the sound signal alarm is realized by outputting different frequencies of sound by the MCU2 to control the buzzer through PWM waves, the light signal alarm is realized by outputting different frequencies of flashing light by the MCU2 to control the LED, and the TFT-LCD realizes the light signal alarm by popping up an alarm dialog box, changing font colors, flashing numbers and the like.

The monitoring system also comprises a mean arterial pressure Monitoring (MAP), wherein the mean arterial pressure Monitoring (MAP) is measured by an invasive arterial pressure sensor 4, and the invasive arterial pressure sensor 4 is electrically connected with the independent monitoring host unit.

EXAMPLE III

The difference between the present embodiment and the first embodiment is:

as shown in fig. 6, the intracranial multiparameter monitoring software includes a start module, a sensor data analysis and operation module, a digital zero setting module, an alarm module, an emWin display module, a serial communication module, a key processing module, and a power management module, all of which allocate priorities according to real-time requirements, execution periods, importance levels, and MCU occupied time.

The start module completes MCU2 hardware initialization, mu C/OS-III initialization, software timer, semaphore and event flag group creation and creation of other all modules on mu C/OS-III kernel, the start module calls OSTaskDel function to delete itself at last, and the start module only runs once; the sensor data analysis and operation module collects invasive arterial pressure IBP measured by an invasive arterial pressure sensor 4, intracranial pressure ICP measured by an intracranial pressure sensor and intracranial temperature ICT measured by a temperature sensor placed in the intracranial, then according to average arterial pressure MAP (IBPas + IBPad)/2, IBPas is invasive arterial systolic pressure, IBPasd is invasive arterial diastolic pressure, average arterial pressure MAP is calculated, according to cerebral perfusion pressure CPP (average arterial pressure-intracranial pressure), namely CPP (CPP) -MAP-ICP, five parameters of intracranial pressure ICP, cerebral perfusion pressure CPP, average arterial pressure MAP and intracranial temperature ICT are displayed through monitoring of three sensors; the digital zero setting module is used for realizing zero setting of the intracranial pressure sensor, the temperature sensor and the invasive arterial pressure sensor 4, the intracranial pressure sensor, the temperature sensor and the invasive arterial pressure sensor 4 are internally provided with storage modules, data such as zero point information, implantation time, patient information and the like are directly recorded, and each sensor is specially corresponding to a corresponding patient; the alarm module uses an event mark group in the mu C/OS-III to represent alarm states of different types, overpressure alarm, error alarm of a calibration parameter of a reading probe, overdue alarm of the use of the probe and low-power alarm are represented by different mark bits in the event mark group, and the alarm module carries out 'setting' and 'zero clearing' treatment on different mark bits in the event mark group according to the alarm types sent by other modules to finish alarm of different types; the emWin display module completes the numerical display of the intracranial pressure ICP and the cranial temperature ICT, the display of the intracranial pressure ICP and the cerebral perfusion pressure CPP in a waveform mode and refreshes the waveform, the display module receives window messages sent by other modules, calls a GUI _ Delay function to refresh a screen area at regular time, completes interface interaction, and sets the emWin display module to be in a lower priority level in order to avoid influencing the operation of a module with higher real-time requirement; the serial port communication module completes the communication between the MCU2 and the MCU1 in the intracranial probe; the key processing module completes the response to the key operation of the user, and sets the higher priority of the key processing module in order to avoid overlong key response time; the electric quantity scanning module completes battery electric quantity monitoring, reminds a guardian to connect the power adapter to the monitoring host in time when the battery power supply is not enough, and prevents the equipment from being powered off suddenly.

When in use, the intracranial pressure probe is implanted into the brain of a patient in a bolt type or tunnel type embedding mode, the intracranial probe acquires intracranial pressure and cranial temperature signals, electric signals are processed into data through an interface end 3 and then transmitted to an independent monitoring host unit through a data line, an invasive arterial pressure sensor 4 which is independently arranged measures the invasive arterial pressure IBP, the average arterial pressure MAP is calculated through the invasive arterial pressure IBP, then the cerebral perfusion pressure CPP is calculated through the average arterial pressure MAP-intracranial pressure ICP, the brain perfusion pressure CPP is displayed in various forms through an interaction module, five parameters of the invasive arterial pressure IBP, the average arterial pressure MAP, the intracranial pressure, the intracranial temperature ICT and the cerebral perfusion pressure CPP are monitored simultaneously, and intracranial multi-parameter monitoring software comprises a starting module, a sensor data analysis and operation module, a digital zero setting module, an alarm module, an emWin display module, a serial port communication module, a key processing module and a power supply management module, all modules distribute priorities according to real-time requirements, execution cycles, importance degrees and MCU time occupation, and software and hardware are matched to complete simultaneous monitoring of five parameters of a single patient.

Wherein, the MCU1 and the MCU2 are preferably STM32 or PGA 309.

The method combines a data acquisition line of the intracranial pressure ICP and a data acquisition line of the brain temperature ICT into one acquisition probe, can acquire the ICP data and the ICT data of the intracranial pressure at the same time, calculates the average arterial pressure MAP according to the measured invasive arterial pressure IBP, calculates the cerebral perfusion pressure CPP by subtracting the intracranial pressure ICP from the average arterial pressure MAP, and can monitor five parameters of the intracranial pressure ICP, the intracranial temperature ICT, the cerebral perfusion pressure CPP, the invasive arterial pressure IBP and the average arterial pressure MAP at the same time; the double-CPU operation mode and the double-platform operation mode are adopted, so that the response speed is high, and the stability of the system can be guaranteed; the full-touch and key-press dual-operation platform is adopted, so that the structure is reliable, and the portability is not lost; the probe is internally provided with a memory chip, zero point information and implantation time can be directly recorded, and when a plurality of patients share one host, the probe can be plugged and pulled out immediately without other additional operations; the intracranial pressure monitor can be connected with a bedside monitor and displays pressure waveforms. If the bedside monitor is connected with the central monitor, data can be directly transmitted to the central monitor, the intracranial pressure monitor can also be matched with a computer workstation to display intracranial pressure ICP (inductively coupled plasma) in a waveform mode, real-time data storage is realized, and the data can be conveniently checked and read in the future.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by using the contents of the present specification and the accompanying drawings, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims

1. An intracranial multiparameter monitoring system based on sensors, characterized in that: the intracranial multi-parameter monitoring software comprises a starting module, a sensor data analysis and operation module, a digital zero setting module, an alarm module, an emWin display module, a serial communication module, a key processing module and a power management module, wherein all the modules distribute priorities according to real-time requirements, an execution cycle, an importance degree and MCU occupation time.

2. The sensor-based intracranial multiparameter monitoring system according to claim 1, wherein: the intracranial probe comprises a probe end (1), a probe tube body (2) and an interface end (3), wherein the probe end (1) comprises an intracranial pressure sensor and a temperature sensor, an analog-to-digital converter for processing signal conversion, a MCU1 for processing data and a storage unit for storing data are arranged in the interface end (3), and a sensor interface circuit, an interaction module, a serial port signal conversion module circuit and a wake-up circuit are further arranged in the interface end (3).

3. A sensor-based intracranial multiparameter monitoring system according to claim 2, wherein: the intracranial pressure sensor is a miniature pressure sensor adopting a half-bridge structure of a classic Wheatstone bridge, is connected with an external bridge matching unit through a bonding wire to form a Wheatstone full bridge, converts a pressure signal into a differential voltage signal, converts an analog signal into a digital signal through an analog-to-digital converter after differential amplification of a differential amplification circuit, and automatically calibrates through a self-calibration circuit.

4. A sensor-based intracranial multiparameter monitoring system according to claim 3, wherein: the miniature pressure sensor comprises two piezoresistors R3 and R4, when the miniature pressure sensor is pressed, the resistance value of the piezoresistor R3 is increased, the resistance value of the R4 is reduced, the balance condition of the Wheatstone bridge is not satisfied, and differential voltage is generated between the point A and the point B; in an external half-bridge circuit of the bridge matching unit, R5, R6 and R7 are connected in parallel and then connected in series with a slide rheostat R1, the bridge matching unit is equivalent to an adjustable resistor R1 in the half-bridge circuit of a Wheatstone bridge, R8, R9 and R10 are connected in parallel and then connected in series with the slide rheostat R2, numbers 1, 2, 3, 4 and 5 in the adjustable resistor R2 and P2 in the half-bridge circuit of the Wheatstone bridge are equivalent to five independent bonding pads, after a micro pressure sensor bonding pad in an intracranial pressure probe is led out by using three enameled wires, then the enameled wires are welded on the P2 bonding pads 2, 3 and 4 to complete the matching of the Wheatstone bridge, after the bonding pad of the miniature temperature sensor in the probe is led out by using two enameled wires, and then the enameled wires are welded on the P2 bonding pads 1 and 5, the PreIN + and the PreIN-are equivalent to the point A and the point B, and the TempR + and the TempR-are connected with a subsequent voltage division circuit and used for collecting temperature signals.

5. The sensor-based intracranial multiparameter monitoring system according to claim 1, wherein: the independent monitoring host unit comprises a power supply management module for power supply management, a storage module for data storage, an interaction module for human-computer interaction, a serial port signal conversion module for communication with the signal acquisition unit and an external network, an MCU2 core board module for managing other components and an alarm module for sending out an alarm signal when abnormality occurs.

6. A sensor-based intracranial multiparameter monitoring system according to claim 5, wherein: the power management module comprises a USB power supply module, an adapter power supply module and a battery power supply module, and provides power for the independent monitoring host unit in multiple modes, the adapter is used for supplying power to the host during long-term bedside monitoring, the battery is used for supplying power to the monitoring host in a short time when a patient is moved, and the USB interface is used for data export and also can supply power to the monitoring host; the storage module is used for recording the time for monitoring the intracranial pressure ICP and the intracranial temperature ICT of the patient and recording data, and guiding medical care personnel to judge the condition of the patient and take medicine; the interaction module comprises a TFT-LCD and a key, a user finishes the operation of the host unit by using the key and the TFT-LCD, the operation comprises menu setting, alarm threshold setting, time setting and zero clearing confirmation, the TFT-LCD is used for displaying the intracranial pressure ICP, the cranial temperature ICT, the invasive arterial pressure IBP and the mean arterial pressure MAP in numerical values, and the intracranial pressure ICP and the cerebral perfusion pressure CPP in waveform; the serial port communication module is used for communicating with the MCU1 in the intracranial probe; the alarm module comprises a TFT-LCD, an LED and a buzzer and provides sound and light signal alarm, the sound signal alarm is realized by outputting different frequencies of sound by the MCU2 to control the buzzer through PWM waves, the light signal alarm is realized by outputting different frequencies of flashing light by the MCU2 to control the LED, and the TFT-LCD realizes the light signal alarm by popping up an alarm dialog box, changing font colors, flashing numbers and the like.

7. The sensor-based intracranial multiparameter monitoring system according to claim 1, wherein: the monitoring system also comprises a mean arterial pressure monitoring unit (MAP), wherein the mean arterial pressure monitoring unit (MAP) is measured by an invasive arterial pressure sensor (4), and the invasive arterial pressure sensor (4) is electrically connected with the independent monitoring host unit through a data line.

8. The sensor-based intracranial multiparameter monitoring system according to claim 1, wherein: the start module completes MCU2 hardware initialization, mu C/OS-III initialization, software timer, semaphore and event flag group creation and creation of other all modules on mu C/OS-III kernel, the start module calls OSTaskDel function to delete itself at last, and the start module only runs once; the sensor data analysis and operation module collects invasive arterial pressure IBP measured by an invasive arterial pressure sensor (4), intracranial pressure ICP measured by an intracranial pressure sensor and intracranial temperature ICT measured by a temperature sensor placed in the intracranial, then calculates average arterial pressure (CPP) according to the average arterial pressure MAP (IBPas + IBPad)/2, IBPas is invasive arterial systolic pressure and IBPad is invasive arterial diastolic pressure, calculates average arterial pressure (MAP) according to the cerebral perfusion pressure CPP (average arterial pressure MAP-intracranial pressure) and realizes the monitoring of three sensors to display five parameters of intracranial pressure, ICP invasive arterial pressure IBP, CPP, MAP and ICT; the digital zero setting module is used for realizing zero setting of the intracranial pressure sensor, the temperature sensor and the invasive arterial pressure sensor (4), and the intracranial pressure sensor, the temperature sensor and the invasive arterial pressure sensor (4) are internally provided with storage modules for directly recording data such as zero point information, implantation time, patient information and the like, so that each sensor is specially corresponding to a corresponding patient; the alarm module uses an event mark group in the mu C/OS-III to represent alarm states of different types, overpressure alarm, error alarm of a calibration parameter of a reading probe, overdue alarm of the use of the probe and low-power alarm are represented by different mark bits in the event mark group, and the alarm module carries out 'setting' and 'zero clearing' treatment on different mark bits in the event mark group according to the alarm types sent by other modules to finish alarm of different types; the emWin display module completes the numerical value display of the intracranial pressure ICP and the cranial temperature ICT, the waveform display of the intracranial pressure ICP and the cerebral perfusion pressure CPP and the time refreshing, the display module receives window messages sent by other modules, calls a GUI _ Delay function to refresh a screen area at regular time, and completes interface interaction; the serial port communication module completes the communication between the MCU2 and the MCU1 in the intracranial probe; the key processing module completes the response to the key operation of the user; the electric quantity scanning module completes battery electric quantity monitoring, reminds a guardian to connect the power adapter to the monitoring host in time when the battery power supply is not enough, and prevents the equipment from being powered off suddenly.

9. A sensor-based intracranial multiparameter monitoring system according to claim 8, wherein: in order to avoid influencing the operation of a module with higher real-time requirement, the emWin display module is set to be in lower priority, and in order to avoid overlong key response time, the key processing module is set to be in higher priority.