CN103990174B - Powerful liquid absorption and drainage dressing, preparation method thereof and liquid absorption and drainage device - Google Patents
Powerful liquid absorption and drainage dressing, preparation method thereof and liquid absorption and drainage device Download PDFInfo
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- CN103990174B CN103990174B CN201410240612.8A CN201410240612A CN103990174B CN 103990174 B CN103990174 B CN 103990174B CN 201410240612 A CN201410240612 A CN 201410240612A CN 103990174 B CN103990174 B CN 103990174B
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- Materials For Medical Uses (AREA)
Abstract
The invention discloses a powerful liquid absorption and drainage dressing, a preparation method thereof and a liquid absorption and drainage device. The powerful liquid absorption and drainage dressing comprises a vertical absorption layer, a middle layer and an absorptive diffusion layer which are adhered in sequence, wherein the vertical absorption layer is made of hydrophobic fibers and hydrophilic fibers; the content of the hydrophobic fibers is over 30 percent of the total weight of the vertical absorption layer; the middle layer is made of hydrophilic fibers or absorbent paper; the absorptive diffusion layer is made of hydrophilic fibers and hydrophobic fibers which account for below 50 percent of the total weight of the absorptive diffusion layer. The powerful liquid absorption and drainage dressing can be used for vertically guiding moisture, has high hygroscopic property, and can be used for transmitting inflammatory mediator-containing seepage, including carrions, bacteria, substrate metalloprotease, biological films and the like which are adsorbed deep into tissues out to promote healing of wounds.
Description
Technical field
The present invention relates to medical material tech field, be specifically related to a kind of strong fluid aspirating drain dressing and preparation method thereof and imbibition drainage system.
Background technology
All there is a large amount of sepages, inflammatory mediator, slough, matrix metalloproteinase and biomembrane in wound organ-tissue tissue from shallow to deep, these materials and normal cell mix to interweave and exist, and are the basic reasons causing bacterial growth, the wound refused to heal.Current dressing is only the object being reached absorption, locking sepage by the imbibition of water wetted material, cannot reach the object of " slough, deep antibacterial, matrix metalloproteinase, biomembrane and the synchronous adsorption removal containing the sepage of inflammatory mediator ".
The hygroscopicity of fiber wound dressing main is at present generally between 12-20 gram/100 square centimeters.The grammes per square metre of these dressing is generally between 100-150 gram/m, and therefore its hygroscopicity is limited, is the highlyest no more than 25 grams/100 square centimeters.Therefore when wound exudate is more, this kind of dressing is difficult to reply, and needing increases change of dressing number of times to adapt to the requirement of wound care.Clinically, the dressing of hygroscopicity higher (such as more than 30 grams/100 square centimeters) is wished.More importantly, as long as there has been imbibition in current wound dressing region, liquid then can very fast diffusion to other regions, the healthy skin of wound perimeter is such as diffused into from wound, this is very undesirable situation, because the healthy skin of periphery can sustain damage because being flooded by wound exudate for a long time like this.
Current wound dressing is difficult to beyond liquid transfer to dressing, can only by change of dressing after imbibition is saturated.If when wound fluid is a lot, need frequent more change dressings, the use cost not only causing patient raises, and patient also can be caused uncomfortable, affect wound healing.Meanwhile, existing dressing, due to it is emphasised that the sepage locking absorbing expansion and cause it to adsorb accumulates in dressing and cannot shift, constrains its liquid absorption.Simultaneously cannot provide self-dissolving, enzyme decomposes, phagocyte engulfs decomposition occasion for the slough bulky grain be adsorbed to inside dressing.
Summary of the invention
In order to overcome the deficiencies in the prior art, the object of the present invention is to provide a kind of strong fluid aspirating drain dressing, can vertically lead wet, there is high-hygroscopicity, the slough bulky grain wherein adsorbed can be resolved into granule, organize deep matrix metalloproteinase, the biomembrane, antibacterial etc. that liquid can be comprised again absorption pass, and promote the healing of wound.
Another object of the present invention is to the preparation method that a kind of strong fluid aspirating drain dressing is provided, to obtain a kind of strong fluid aspirating drain dressing with high-hygroscopicity.
For solving the problem, the technical solution adopted in the present invention is as follows:
A kind of strong fluid aspirating drain dressing, it comprise fit successively vertical absorbed layer, intermediate layer and absorption diffusion layer, described vertical absorbed layer is that raw material is made by hydrophobic fiber and hydrophilic fibers, and wherein with the total weight of described vertical absorbed layer, the content of hydrophobic fiber is more than 30%; Described intermediate layer is that hydrophilic fibers or absorbent paper are made; Described absorption diffusion layer is made by hydrophilic fibers with the hydrophobic fiber of the total weight less than 50% absorbing diffusion layer.
The wound-contacting layer of common hydroscopic dressings is difficult to the problem avoiding liquid cross conduction.In the present invention, inventor finds can slow down containing a certain proportion of hydrophobic fiber the horizontal proliferation even stoping liquid through research.Therefore described vertical absorbed layer adopts hydrophobic fiber and hydrophilic fibers to be composited, wound exudate effectively can be conducted to intermediate layer rapidly by it, and this conduction is almost vertical, namely seldom even cross conduction is not had, make most wound exudate be conducted to intermediate layer rapidly, instead of diffuse to periphery; Wherein with the total weight of described vertical absorbed layer, the content of hydrophobic fiber is more than 30%, preferably more than 60%.And intermediate layer adopts hydrophilic fibers or absorbent paper, can come extending transversely fast for liquid, pass to absorption diffusion layer, the superpower imbibition of absorption diffusion layer can be made like this and keep the ability of liquid to give full play of.The major function of described absorption diffusion layer is moisture absorption and moisturizing; Inventor also finds, if absorb diffusion layer only adopt hydrophilic fibers, its moistening effect is undesirable, and adopt the too high levels of hydrophobic fiber or hydrophobic fiber to be unfavorable for absorbing the moisture absorption of diffusion layer completely, therefore absorption diffusion layer of the present invention adopts hydrophilic fibers and adds the effect that a certain amount of hydrophobic fiber can make moisture absorption and moisturizing all reach good simultaneously; Wherein with the total weight of described absorption diffusion layer, the content of hydrophobic fiber is less than 50%, preferably less than 20%.
As preferred embodiments of the present invention, the grammes per square metre of described vertical absorbed layer is between 50-350 gram/m, and the grammes per square metre in described intermediate layer is between 50-150 gram/m, and the grammes per square metre of described absorption diffusion layer is between 80-400 gram/m.
In the present invention, as preferred scheme, in described vertical absorbed layer, hydrophobic fiber is polyster fibre, polypropylene fiber, nylon fiber, polyethylene fibre, hydrophobic chitin fiber, polypropylene/own synthetic fibre bicomponent fibre, nylon/polyethylene bicomponent fibre, one or more in terylene/nylon bicomponent fibre are with arbitrarily than mixing, hydrophilic fibers is bamboo carbon fiber, bamboo fiber, bamboo pulp fiber, NACF, viscose rayon, cotton fiber, flaxen fiber, Time of Fluff Slurry, Bacterial cellulose, water suction acrylic fiber, water suction polypropylene fiber, Lyocell fibers, calcium alginate fibre, water suction chitin fiber, carboxymethyl cellulose fiber, carboxyethylcellulose cellulose fiber, acylation chitosan fiber, carboxymethyl chitosan fiber and derivant thereof are (as Aloe extraction solution, the hydrophilic fibers that cactus extraction etc. processed) in one or more with arbitrarily than mixing.
In the present invention, as preferred scheme, in described intermediate layer, hydrophilic fibers is that one or more in bamboo carbon fiber, bamboo fiber, bamboo pulp fiber, NACF, viscose rayon, cotton fiber, flaxen fiber, Time of Fluff Slurry, Lyocell fibers, wood pulp cellulose, straw pulp fiber are with arbitrarily than mixing.
In the present invention, as preferred scheme, in described absorption diffusion layer, hydrophilic fibers is one or more mixing in bamboo carbon fiber, bamboo fiber, bamboo pulp fiber, NACF, viscose rayon, cotton fiber, flaxen fiber, Time of Fluff Slurry, Lyocell fibers, superabsorbent water crosslinking acrylic fiber, wood pulp cellulose, straw pulp fiber, and hydrophobic fiber is one or more mixing in polyster fibre, polypropylene fiber, nylon fiber, polyethylene fibre, polypropylene/polyethylene bicomponent fibre, nylon/polyethylene bicomponent fibre, terylene/nylon bicomponent fibre.
The vertical absorbed layer of strong fluid aspirating drain dressing of the present invention generally directly can spread on wound surface.But for burn and scald, hypotonic and dry wound surface, before using this strong fluid aspirating drain dressing, need in the dressing of wound surface first application one deck anti-adhesive, as: medical sterilization kpetrolatum gauze, for preventing and wound surface adhesion, there is lubrication, sticky wound, promote that granulation grows, promote the effect of wound healing.
In the present invention, preparing strong fluid aspirating drain dressing can be realized by following three kinds of modes.
First kind of way concrete steps are as follows:
1) vertical absorbed layer, intermediate layer and absorption diffusion layer is made respectively;
2) by step 1) in vertical absorbed layer, intermediate layer and the absorption diffusion layer made be combined with each other by the order of vertical absorbed layer, intermediate layer and absorption diffusion layer successively;
3) by step 2) product made is cut, pack after sterilizing.
Second way concrete steps are as follows:
1) vertical absorbed layer and intermediate layer is made respectively;
2) by step 1) in the vertical absorbed layer made and intermediate layer compound, obtain composite bed;
3) in step 2) composite bed on directly preparation absorb diffusion layer;
4) by step 3) product made is cut, pack after sterilizing.
The third mode concrete steps are as follows:
1) make intermediate layer respectively and absorb diffusion layer;
2) by step 1) in the intermediate layer made and absorb diffusion layer compound, obtain composite bed;
3) in step 2) composite bed on directly prepare vertical absorbed layer;
4) by step 3) product made is cut, pack after sterilizing.
In the present invention, as preferred scheme, in described acupuncture course, needling density is no more than 400/ square centimeter.
A kind of imbibition drainage system, comprises strong fluid aspirating drain dressing of the present invention and described strong fluid aspirating drain dressing is fixed on the fixture of site of injury.Wherein the structure of fixture is any one structure that dressing of the present invention can be realized to be fixed on site of injury, as passed through the forms such as bandage, buckle or stickers.
Compared to existing technology, beneficial effect of the present invention is:
1. strong fluid aspirating drain dressing of the present invention can multiplely stack up use, or puts together with crossover with contacting with each other, and can be only have the wound of one or more and required process directly to contact like this, when multiple strong fluid aspirating drain dressing uses simultaneously, only has one of them direct and Wound contact, secretions shifts to another strong fluid aspirating drain dressing or its contiguous strong fluid aspirating drain dressing by capillarity by from the strong fluid aspirating drain dressing that wound directly contacts with antibacterial, one of them strong fluid aspirating drain dressing or directly contact with above-mentioned another strong fluid aspirating drain dressing directly contacting wound, or contacted with the above-mentioned strong fluid aspirating drain dressing directly contacting wound by middle one or more strong fluid aspirating drain dressing, realize the secretions drain of wound surface and shift away,
2. strong fluid aspirating drain dressing of the present invention can be cut into arbitrary shape, with the wound surface of fit difformity and size; Can also according to clinical needs external sepage drainage bag drain sinus tract fistula deep exudate;
3. strong fluid aspirating drain dressing of the present invention may be used for coated very eurypalynous wound, and this wound includes but not limited to burn, infected wound, wound, diabetic foot wound, tumor wound, mycete wound, wound, tenderness, leg ulcer, leprosy wound, amputation wounds, chronic wounds, radiation injury, firearm injury, metallic weapon incision and the epidermis relevant to the HIV wound of human and animal; When using strong fluid aspirating drain dressing of the present invention, be not limited to superficial cut, can also be inserted in gash or otch, for imbibition and drain in conjunction with miscellaneous part equally;
4. strong fluid aspirating drain dressing of the present invention not only can absorb wound exudate, and secretions, antibacterial, slough, biomembrane, matrix metalloproteinase etc. can be made away from wound because of the capillary effect in this strong fluid aspirating drain dressing structure; This strong fluid aspirating drain dressing can remove downright bad tissue, removes the nutrient of biomembrane (biofilm), reduces the cytokine that wound surface is harmful;
5. strong fluid aspirating drain dressing of the present invention may be used for the stench discharging wound; Due to the absorbability that strong fluid aspirating drain dressing is superpower, the stink of wound release can be adsorbed, reduce stink to the discharge in air;
6. strong fluid aspirating drain dressing of the present invention has capillary effect, the negative-pressure sucking utilizing the water potential energy pressure differential at capillary tube two ends in fiber to produce and secretions is discharged by the drainage of dressing, realize the transfer absorption of secretions, absorbed like this liquid can be transferred to the material position of relatively dry; In addition, because the outer surface of vertical absorbed layer is relatively inviscid, so strong fluid aspirating drain dressing can cosily in the face of wound when processing wound;
7. strong fluid aspirating drain dressing of the present invention effectively can promote that wound surface newly granulates generation, reduces edema and eschar, thus accelerates the healing of wound surface;
8. strong fluid aspirating drain dressing of the present invention can also be used for wiping blood in operation, absorbs sepage, absorb body fluid.
Below in conjunction with the drawings and specific embodiments, the present invention is described in further detail.
Accompanying drawing explanation
Fig. 1 is the structural representation of strong fluid aspirating drain dressing of the present invention;
Fig. 2 is each group interstitial area area (n=6) variation diagram in the dark II degree of scald wound model necrosis progrediens Inhibition test of rat;
Fig. 3 is each group scald wound degree of depth (n=6) variation diagram in the dark II degree of scald wound model necrosis progrediens Inhibition test of rat;
Fig. 4 is the rear optical microphotograph eyeglass photo of A group silver dye in rat dark II degree of scald wound inoculation SA model organism film Inhibition test;
Fig. 5 is the rear optical microphotograph eyeglass photo of B group silver dye in rat dark II degree of scald wound inoculation SA model organism film Inhibition test;
Fig. 6 is the rear optical microphotograph eyeglass photo of C group silver dye in rat dark II degree of scald wound inoculation SA model organism film Inhibition test;
Fig. 7 is that in Diabetic Ulcers in Rats metalloproteases Inhibition test, A, B, C group measures situation at the MMP1 of day part;
Fig. 8 is that in Diabetic Ulcers in Rats metalloproteases Inhibition test, A, B, C group measures situation at the MMP2 of day part.
Detailed description of the invention
EXAMPLE l
As shown in Figure 1, a kind of strong fluid aspirating drain dressing, it comprises:
Vertical absorbed layer 3: the polyster fibre containing 65% weight, its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter; The bamboo carbon fiber of 35% weight, its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter; Two kinds of fibers weigh in proportion respectively after again through Homogeneous phase mixing, then shredding, combing, lapping acupuncture becomes cloth, needling density is 350/ square centimeter; The grammes per square metre making fabric is 250 grams/m;
Intermediate layer 2: the cotton fiber containing 100% weight, its fibre number is 1.5-2.5 denier, and length is 25-35 millimeter; Mix after weighing, then shredding, combing, lapping acupuncture becomes cloth; The grammes per square metre making fabric is 80 grams/m;
Absorb diffusion layer 1: the superabsorbent water crosslinking acrylic fiber containing 35% weight, its fibre number is 2.0-2.7 denier, and length is 10-15 millimeter; The wood pulp cellulose of 45% weight, its fibre number is 2.0-2.5 denier, and length is 10-15 millimeter; Polyster fibre containing 20% weight, its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter; Three kinds of fibers weigh in proportion respectively after again through Homogeneous phase mixing, then shredding, combing, lapping acupuncture becomes cloth, needling density is 350/ square centimeter; The grammes per square metre making fabric is 320 grams/m; Then with needle point method, described three layers are combined with each other;
The fabric of preparation is cut into 10 × 10cm, then packaging and through Co 60 sterilizing, the grammes per square metre of strong fluid aspirating drain dressing is 650 grams/m.
Embodiment 2
A kind of strong fluid aspirating drain dressing, it comprises:
Vertical absorbed layer: the hydrophobic chitin fiber containing 60% weight, its fibre number is 2.2 denier, and length is 51 millimeters; The viscose rayon of 40% weight, its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter; Two kinds of fibers weigh in proportion respectively after again through Homogeneous phase mixing, then shredding, combing, lapping acupuncture becomes cloth, needling density is 400/ square centimeter; The grammes per square metre making fabric is 200 grams/m;
Intermediate layer: the viscose rayon containing 30% weight, its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter; The cotton fiber of 70% weight, its fibre number is 1.5-2.5 denier, and length is 25-35 millimeter; Two kinds of fibers weigh in proportion respectively after again through Homogeneous phase mixing, then shredding, combing, lapping acupuncture becomes cloth; The grammes per square metre making fabric is 80 grams/m;
Absorb diffusion layer: the bamboo carbon fiber containing 35% weight, its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter; The viscose rayon of 40% weight, its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter; The polypropylene fiber of 25% weight, its fibre number is 2.0-2.5 denier, and length is 38 millimeters; Three kinds of fibers weigh in proportion respectively after again through Homogeneous phase mixing, then shredding, combing, lapping acupuncture becomes cloth, needling density is 350/ square centimeter; The grammes per square metre making fabric is 320 grams/m;
Vertical absorbed layer, intermediate layer and absorption diffusion layer fabric are laid in as required on curtain at the bottom of lapping machine, feeding needing machine, punch frequency is 200/ square centimeter, realizes the compound of treble cloths;
The fabric of preparation is cut into 10 × 10cm, and then packaging also ethane via epoxyethane sterilizing, the grammes per square metre of strong fluid aspirating drain dressing is 600 grams/m.
Embodiment 3
A kind of strong fluid aspirating drain dressing, it comprises:
Vertical absorbed layer: the polyster fibre containing 60% weight, its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter; The cotton fiber of 40% weight, its fibre number is 1.5-2.5 denier, and length is 25-35 millimeter; Two kinds of fibers weigh in proportion respectively after again through Homogeneous phase mixing, then shredding, combing, lapping acupuncture becomes cloth, needling density is 350/ square centimeter; The grammes per square metre making fabric is 250 grams/m;
Intermediate layer: the viscose rayon containing 30% weight, its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter; The bamboo fiber of 70% weight, its fibre number is 5-6 denier, and length is 80-90 millimeter; Two kinds of fibers weigh in proportion respectively after again through Homogeneous phase mixing, then shredding, combing, lapping acupuncture becomes cloth, the grammes per square metre making fabric is 80 grams/m;
Absorb diffusion layer: the bamboo carbon fiber containing 35% weight, its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter; The viscose rayon of 50% weight, its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter, the polyster fibre containing 15% weight, and its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter; Three kinds of fibers weigh in proportion respectively after again through Homogeneous phase mixing, then shredding, combing, lapping acupuncture becomes cloth, needling density is 350/ square centimeter.The grammes per square metre making fabric is 320 grams/m;
Vertical absorbed layer, intermediate layer and absorption diffusion layer fabric are superimposed as required, put into baking oven and carry out hot melt compound;
The fabric of preparation is cut into 10 × 10cm, and then packaging also ethane via epoxyethane sterilizing, the grammes per square metre of strong fluid aspirating drain dressing is 650 grams/m.
Embodiment 4
A kind of strong fluid aspirating drain dressing, it comprises:
Vertical absorbed layer: the polypropylene fiber containing 70% weight, its fibre number is 2.0-2.5 denier, and length is 38 millimeters; The Lyocell fiber of 30% weight, its fibre number is 1.7 denier, and length is 51 millimeters; Two kinds of fibers weigh in proportion respectively after again through Homogeneous phase mixing, then shredding, combing, lapping;
Intermediate layer: the viscose rayon containing 30% weight, its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter; The cotton fiber of 70% weight, its fibre number is 1.5-2.5 denier, and length is 25-35 millimeter, two kinds of fibers weigh in proportion respectively after again through Homogeneous phase mixing, then shredding, combing, lapping acupuncture becomes cloth; The grammes per square metre making fabric is 80 grams/m;
Absorb diffusion layer: the viscose rayon of 85% weight, its fibre number is 2.0-2.5 denier, length is 45-55 millimeter, polyster fibre containing 15% weight, its fibre number is 2.0-2.5 denier, and length is 45-55 millimeter, two kinds of fibers weigh in proportion respectively after again through Homogeneous phase mixing, then shredding, combing, lapping acupuncture becomes cloth; Needling density is 350/ square centimeter, and the grammes per square metre making fabric is 320 grams/m.
When preparing vertical absorbed layer, by intermediate layer with absorb diffusion layer fabric according to the order of sequence (absorb diffusion layer fabric under, intermediate layer fabric is upper) be placed on curtain at the bottom of lapping machine, then shredding, combing and lapping operation is started, the fleece of vertical absorbed layer is made directly to be layered on intermediate layer (absorbing diffusion layer in bottom), feed needing machine together, punch frequency is 150/ square centimeter, make the fiber of vertical absorbed layer sting intermediate layer and outside a straight thrust to absorption diffusion layer, treble cloths be combined with each other.The average grammes per square metre of vertical absorbed layer is 300 grams/m;
The fabric of preparation is cut into 10 × 10cm, then packaging and through Co 60 sterilizing, the grammes per square metre of strong fluid aspirating drain dressing is 700 grams/m.
Detection experiment
Utilize mice bum model to test to test the effect of strong fluid aspirating drain dressing of the present invention, specific experiment is as follows.
1. after acute injury, microbionation rat model wound surface antibacterial removes experiment
1.1 experiment groupings
SD rat 36, between body weight 200 ~ 250g, point A, B, C tri-groups, often organize 12, concrete grouping situation is in table 1.
Table 1: the grouping of laboratory animal
| Group | Dispose | Number of animals (only) | Wound surface number (individual) |
| A | Strong fluid aspirating drain dressing | 12 | 12 |
| B | Common dressing | 12 | 12 |
| C | Blank group | 12 | 12 |
1.2 experimental procedure
1.2.1 modelling: each group of rat is pressed 2ml/kg intraperitoneal injection of anesthesia with 15% chloral hydrate respectively.Anaesthetizing ventricumbent position is successfully fixed on rat operating console by extremity, back chaeta is rejected with electric pet shaver, clear water rinses, 75% alcohol disinfecting, the full thickness dermal wounds of diameter 3cm is made at every rat back side rustless steel self-made punching device, local hydrogen peroxide, hibitane, normal saline flushing, wound surface surrounding skin 75% alcohol disinfecting, sterile gauze is dried.
1.2.2 wound surface connects bacterium: be 1 × 10 by the concentration be equipped with
9the escherichia coli (EC) of cfu/ml, staphylococcus aureus (SA), pseudomonas aeruginosa (PSA) suspension, drip 0.5ml in wound surface with 1ml syringe, treat its NATURAL DISTRIBUTION.After ten minutes, strong fluid aspirating drain dressing, common dressing are individually fixed in and respectively form face, within 12 hours, change once, observe after 24 hours.
1.2.3 wound surface antibacterial gathers: dip normal saline (at 5ml physiological saline solution in vitro) with aseptic cotton carrier, rolled to opposite side by wound surface side, uniform application wound surface once after, insert in a dry sterile test tube immediately, put into again after 1ml physiological saline solution scrubs dilution and be inoculated in MH culture dish, 37 ° of constant temperature culture are after 24 hours, and the bacterium colony of counting inoculated and cultured ware forms number (cfu); Wound surface inoculated bacteria is after ten minutes (means intervene before), after 24 hours, measure wound surface EC, SA, PSA quantity respectively; According to the count of bacteria value mean of formula (after ten minutes count of bacteria value mean after-24 hours count of bacteria value mean)/after ten minutes, calculate the removal rate of A, B, C group to three kinds of different bacterium and compare; The process of all data SPSS16.0 statistical softwares, carry out variance analysis respectively and compare and multiple comparisons between multiple sample average, P<0.05 is for there being significant difference.
1.3 wound surface bacteria cultivation results: carry out the collection of wound surface antibacterial, after inoculated and cultured, calculate each group of bacterial number; Analyze comparing result in table 2.
Table 2: after wound, 24h is to the comparison (%) of wound surface EC, SA, PSA removal rate mean
| Group | EC | SA | PSA |
| A | 78.82* | 76.11* | 82.36* |
| B | 3.57☆ | 3.40☆ | 3.77☆ |
| C | 1.96 | 2.01 | 1.49 |
* note: A group compares with B, C group, P<0.05 has significant difference
☆ note: B group compares with C group, P>0.05, there was no significant difference
Result in table 2 shows, strong fluid aspirating drain dressing effectively can remove the malignant bacterias such as EC, PSA, SA in 24 hours.
2. the dark II degree of scald wound model necrosis progrediens Inhibition test of rat
2.1 experimental procedure
2.1.1 modelling: the copper pectination scalding model that test is invented with reference to Regas FC and Ehrlich HP, special copper comb scalds device, heavy 150g, be made up of 4 outstanding comb, the wide 10mm of each comb, long 20mm, after being heated, contacting skin, forming scald wound; Be 3 matrix gaps between comb, each wide 5mm, long 20mm, does not contact skin during scald, and the region of formation is called interstitial area; Rat back is used electric hair cutter unhairing the previous day by experiment, and clear water is cleaned, and avoids causing skin irritation.Give the 1% pentobarbital sodium intraperitoneal injection of anesthesia of 40mg/kg by the weight of animals, be fixed on animal experimental table, special copper comb is scalded device and be immersed in boiling water (surveying water temperature is 100 DEG C) boiled in advance, homogeneous heating 5 minutes, is stained with dry; First be placed on side, rat back center line both sides and open 0.5cm place skin, do not apply any pressure, the time of contact corresponding to skin is 20s; Each obtained 4 scald wounds in both sides, back and interstitial area that between them, three are not scalded thus.Give monolayer oil gauze flap coverage after wound, do not do other process; Hinder and cut part wound tissue specimen with scalpel in latter 2 hours; Specimen is that the part that 3 × 10mm comprises interstitial area and both sides thereof scalds district's full thickness skin tissue, namely puts in 10% paraformaldehyde and spends the night; Come card Automation-tissue-dehydrating machine is put into after specimen shifts out; Next day paraffin embedding, to be cooled fixing after, do 4 μm of thick sections, dry; HE dyes, gradient alcohol dehydration, transparent to dimethylbenzene, row histological observation after neutral gum mounting, visible epidermal area degeneration necrosis, the red dye of about 2/3 collagen homogenizing on skin corium, erythrocyte blocking in lower 1/3 visible part thin vessels tube chamber, appendages of skin part cell has core to concentrate or cracking, meets dark II degree of empyrosis wound surface feature.
2.1.2 grouping experiment: be divided into A, B, C tri-groups by after 18 dark II degree of scalds of rats underwent as stated above, often organize 6, use strong fluid aspirating drain dressing (A group), common dressing (B group), blank (C group) process respectively, wherein A group, B group change a dressing in every 12 hours; Observe after cutting part wound tissue specimen paraffin embedding, fixing section, HE dyeing by method described in 2.1.1 after 24 hours and 48 hours; Use GraphPad Prism5.0 software to carry out statistical analysis to experimental data, interstitial area area and Wound depth x ± s represent, compare employing paired t-test between two groups.P<0.05 is for there being significant difference.
2.2 experimental result
2.2.1 wound surface and interstitial area change: wound surface situation gross examination of skeletal muscle, comprises hair and interstitial area area, with or without generation petechia or ecchymosis etc., if any, be then considered as necrosis.Digital camera distance wound surface 20cm vertically makes film preservations, and wound surface other placement steel ruler is as reference, and rear Image pro5.0 image analysis software, detector gap district area change, the results are shown in Figure 2.
The result of Fig. 2 shows: after scald, B, C group interstitial area area continuous decrease, and A group declines after within 24 hours, amassing below and comparatively scalding slightly, and within 48 hours, amass below and substantially remain unchanged, two time points compare with B, C group, equal P<0.05.Illustrate that A group therapeutic effect is obvious, limit the necrosis progrediens of interstitial area.
2.2.2 Wound depth detects: HE stained is put in optical microphotograph Microscopic observation burn wound, with horn cell swelling, the red dye of collagenous degeneration homogenizing is index, determine Wound depth, and use NIF image software, image preserved in record, then uses Image pro5.0 image analysis software, calculates Wound depth; Each group of each time point observes 3 sections, often opens section and gets 5 positions, average, the results are shown in Figure 3.
The result display of Fig. 3: Wound depth B, C group after scald all has intensification in various degree, and A group Wound depth is tending towards reducing.Compare between each time point group, the A group degree of depth is minimum, and B group is taken second place, and C group is maximum; A group compares with B, C group, P<0.05; B group compares with C group, P>0.05.Illustrate that the treatment of A group is effective, limit the intensification of Wound depth.
3. rat dark II degree of scald wound inoculation SA model organism film Inhibition test
3.1 experimental procedures:
3.1.1 modelling: 3 SD rats prepare the dark II degree of scald wound model of rat by the method for above-mentioned 2.1.1, then carry out wound surface SA inoculation by the method for above-mentioned 1.2.1 and 1.2.2 and make the dark II degree scald wound of rat and inoculate SA model.
3.1.2 grouping is tested: 3 rats are divided into A, B, C tri-groups, often organize 1, respectively by strong fluid aspirating drain dressing (A group) of the present invention, common dressing (B group), space management (C group), wherein A group, B group change a dressing in every 12 hours; Within 7 days, cut 3 × 10mm size inoculation wound tissue respectively to observe by after following argentation process.The results are shown in Figure 4-6.
Argentation treatment step is as follows: 1. through sterile saline repeatedly fully rinsing, remove flcating germ; 2. 1h is fixed in 25% glutaraldehyde PBS solution; 3. distilled water cleaning 1min; 4. saturated calcium chloride solution is in conjunction with 15min; 5. distilled water cleaning 1min; 6. 5% silver nitrate solution reaction 15min; 7. 1% quinol solution develops the color 2min; 8. distilled water rinsing 1min; 9. 5% hypo solution fixes 2min; 10. distilled water rinsing 1min.
3.2 experimental result
Fig. 4 is optical microphotograph eyeglass photo after A group silver dye, and the stain be scattered as seen or black speck, without the cotton-shaped film sample thing of black dye; Fig. 5 is optical microscope photograph after B group silver dye, and in figure, black dye part is SA biomembrane in byssaceous film sample thing; Fig. 6 is optical microscope photograph after C group silver dye, and visible bacterial accumulation is agglomerating, forms large stretch of SA biomembrane therebetween.Result shows that strong fluid aspirating drain dressing can the significantly biomembranous formation of anti-bacteria.
4. Diabetic Ulcers in Rats metalloproteases Inhibition test
4.1 experimental procedure
4.1.1 modelling: 3 Wistar rats, body weight 200 ~ 250g, 12h fasting before experiment, quantitatively drinks water; Experiment was weighed the same day, and tail vein blood and collection urine, measure basal plasma glucose and glucose in urine respectively with blood glucose meter and test paper method, then press 150mg/kg body weight lumbar injection 3% alloxan; When animal blood glucose concentration is greater than 11mmol/L and glucose in urine is after 1 week +++ during+(>20g/L), can think that diabetes model copies successfully.Get the diabetes rat 3 of above-mentioned imagineering, after injecting anesthesia with 3% pentobarbital sodium (25mg/kg) abdominal cavity, hair is shaved at back, routine disinfection; Aseptically with special card punch, at Mus back of the body middle part, spinal column both sides are each makes a call to a circular hole, and be deep to subcutaneous, diameter 1.8cm, wound surface area is 2.54cm
2; Use strong fluid aspirating drain dressing (A group), common dressing (B group), blank (C group) process after hemostasis respectively, wherein A group, B group change a dressing in every 12 hours; Every treated animal list cage is fed, quantitatively drinking-water and feeding.Measure the change of the appetite of animal, amount of drinking water, body weight and glucose in urine every day, survey blood glucose 1 time weekly; Supplementary injection alloxan or insulin (2u/ only) mode is adopted to maintain diabetic animal blood glucose between 11 ~ 16.5mmol/L.
4.1.2 experimental technique: cut 4 × 3 × 3mm granulation tissue in wound surface central authorities in the 1st, 4,7 day after Wound treatment respectively, use liquid nitrogen flash freezer immediately, proceed to frozen 2 months of-70 DEG C of refrigerators after 48h; Total serum IgE application Trizol test kit carries out extraction and is placed on-70 DEG C of preservations; Utilize RT-PCR kit amplification MMPI, MMP2 of Promega company, finally measure each product density value by Band-scan scanning system, all products, all through order-checking, confirm to be respectively MMP1, MMP2; The density value of each index of each time point represents with X ± S, analyzes with non-paired t test, and P<0.05 is for there being significant difference.The results are shown in Figure 7 and Fig. 8.
4.2 experimental result
Fig. 7, Fig. 8 are that A, B, C group measures situation at MMP1, MMP2 of day part, result shows, strong fluid aspirating drain dressing can make MMP1 and MMP2 in diabetes chronic wound surface significantly decline, and compared with organizing numerical value with matched group and blank, P<0.05 has significant difference.
In sum, most of pathogenic bacteria of the removable wound surface of strong fluid aspirating drain dressing of the present invention, slough, biomembrane and matrix metalloproteinase.
Above-mentioned embodiment is only the preferred embodiment of the present invention; can not limit the scope of protection of the invention with this, change and the replacement of any unsubstantiality that those skilled in the art does on basis of the present invention all belong to the present invention's scope required for protection.
Claims (5)
1. a strong fluid aspirating drain dressing, it is characterized in that, it comprise fit successively vertical absorbed layer, intermediate layer and absorption diffusion layer, described vertical absorbed layer is that raw material is made by hydrophobic fiber and hydrophilic fibers, wherein with the total weight of described vertical absorbed layer, the content of hydrophobic fiber is more than 30%; Described intermediate layer is that hydrophilic fibers or absorbent paper are made; Described absorption diffusion layer is made by hydrophilic fibers with the hydrophobic fiber of the total weight less than 50% absorbing diffusion layer; The grammes per square metre of described vertical absorbed layer is between 50-350 gram/m, and the grammes per square metre in described intermediate layer is between 50-150 gram/m, and the grammes per square metre of described absorption diffusion layer is between 80-400 gram/m;
In described vertical absorbed layer, hydrophobic fiber is polyster fibre, polypropylene fiber, nylon fiber, polyethylene fibre, hydrophobic chitin fiber, polypropylene/own synthetic fibre bicomponent fibre, nylon/polyethylene bicomponent fibre, one or more in terylene/nylon bicomponent fibre are with arbitrarily than mixing, hydrophilic fibers is bamboo carbon fiber, bamboo fiber, bamboo pulp fiber, NACF, viscose rayon, cotton fiber, flaxen fiber, Time of Fluff Slurry, Bacterial cellulose, water suction acrylic fiber, water suction polypropylene fiber, Lyocell fibers, calcium alginate fibre, water suction chitin fiber, carboxymethyl cellulose fiber, carboxyethylcellulose cellulose fiber, acylation chitosan fiber, one or more in carboxymethyl chitosan fiber and derivant thereof are with arbitrarily than mixing,
In described intermediate layer, hydrophilic fibers is that one or more in bamboo carbon fiber, bamboo fiber, bamboo pulp fiber, NACF, viscose rayon, cotton fiber, flaxen fiber, Time of Fluff Slurry, Lyocell fibers, wood pulp cellulose, straw pulp fiber are with arbitrarily than mixing;
In described absorption diffusion layer, hydrophilic fibers is one or more mixing in bamboo carbon fiber, bamboo fiber, bamboo pulp fiber, NACF, viscose rayon, cotton fiber, flaxen fiber, Time of Fluff Slurry, Lyocell fibers, superabsorbent water crosslinking acrylic fiber, wood pulp cellulose, straw pulp fiber, and hydrophobic fiber is one or more mixing in polyster fibre, polypropylene fiber, nylon fiber, polyethylene fibre, polypropylene/polyethylene bicomponent fibre, nylon/polyethylene bicomponent fibre, terylene/nylon bicomponent fibre.
2. strong fluid aspirating drain dressing as claimed in claim 1, it is characterized in that, it is prepared from by following steps:
1) vertical absorbed layer, intermediate layer and absorption diffusion layer is made respectively;
2) by step 1) in vertical absorbed layer, intermediate layer and the absorption diffusion layer made be combined with each other by the order of vertical absorbed layer, intermediate layer and absorption diffusion layer successively;
3) by step 2) product made is cut, pack after sterilizing.
3. strong fluid aspirating drain dressing as claimed in claim 1, it is characterized in that, it is prepared from by following steps:
1) vertical absorbed layer and intermediate layer is made respectively;
2) by step 1) in the vertical absorbed layer made and intermediate layer compound, obtain composite bed;
3) in step 2) composite bed on directly preparation absorb diffusion layer;
4) by step 3) product made is cut, pack after sterilizing.
4. strong fluid aspirating drain dressing as claimed in claim 1, it is characterized in that, it is prepared from by following steps:
1) make intermediate layer respectively and absorb diffusion layer;
2) by step 1) in the intermediate layer made and absorb diffusion layer compound, obtain composite bed;
3) in step 2) composite bed on directly prepare vertical absorbed layer;
4) by step 3) product made is cut, pack after sterilizing.
5. an imbibition drainage system, is characterized in that: it fixture comprising strong fluid aspirating drain dressing as claimed in claim 1 and described strong fluid aspirating drain dressing is fixed on site of injury.
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| CN201410240612.8A CN103990174B (en) | 2014-05-30 | 2014-05-30 | Powerful liquid absorption and drainage dressing, preparation method thereof and liquid absorption and drainage device |
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| CN201410240612.8A CN103990174B (en) | 2014-05-30 | 2014-05-30 | Powerful liquid absorption and drainage dressing, preparation method thereof and liquid absorption and drainage device |
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| CN103990174B true CN103990174B (en) | 2015-04-15 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105597136A (en) * | 2016-02-01 | 2016-05-25 | 上海昌颌医药科技有限公司 | Moisture-transfer and fast drying wound dressing |
| CN111686295A (en) * | 2020-06-24 | 2020-09-22 | 重庆理工大学 | Seepage self-adjusting composite dressing and preparation method thereof |
| CN114592263A (en) * | 2022-03-14 | 2022-06-07 | 苏州雷池新材料科技有限公司 | Preparation method of degradable alginic acid medical fabric |
| CN114712088B (en) * | 2022-04-01 | 2023-05-16 | 浙江隆腾医用新材料有限公司 | Carboxymethyl cellulose wound dressing |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9900348D0 (en) * | 1999-01-09 | 1999-02-24 | Bristol Myers Squibb Co | Multi layered wound dressing |
| CN101252901A (en) * | 2005-08-31 | 2008-08-27 | 科洛普拉斯特公司 | An absorbent dressing |
| US8454990B2 (en) * | 2008-08-01 | 2013-06-04 | Milliken & Company | Composite article suitable for use as a wound dressing |
| CN103655046B (en) * | 2013-12-03 | 2016-02-03 | 佛山市优特医疗科技有限公司 | A kind of wound dressing with three-decker and preparation method thereof |
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