CN103977223A

CN103977223A - Traditional Chinese medicinal composition for dispelling cold and dredging orifices and preparation method thereof

Info

Publication number: CN103977223A
Application number: CN201410185875.3A
Authority: CN
Inventors: 曾成锋
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-05-05
Filing date: 2014-05-05
Publication date: 2014-08-13

Abstract

The invention discloses a traditional Chinese medicinal composition for dispelling cold and dredging orifices and a preparation method thereof. The composition is prepared from raw materials including the following medicinal materials: radix astragali, fructus liquidambaris, radix angelicae, psoralea corylifolia, Chinese magnoliavine, prepared rehmannia root, fistular onion bulb, lily magnolia, grass-leaved sweetflag rhizome, asarum herb, xanthium, cassia twig, balloonflower root, honey-fried licorice root and the like. The invention also provides the preparation method of the traditional Chinese medicinal composition for dispelling cold and dredging orifices. The composition provided by the invention helps tonify spleen and lung, promote stagnation and dredge orifices, has a precise curative effect of treating symptoms such as rhinitis caused by deficiency of yang, congealing cold and nasal orifice hypothermia, has good safety, and has no side-effect.

Description

Chinese medicine composition that a kind of cold expelling is sensible and preparation method thereof

Technical field

The present invention relates to drug world, be specifically related to sensible Chinese medicine composition of a kind of cold expelling and preparation method thereof.

Background technology

Rhinitis, Traditional Chinese Medicine is called nasal sinusitis, again the sinusitis with purulent discharge of meaning." dialectical record " " sinusitis with purulent discharge be nasal sinusitis also, original cold and heat two are demonstrate,proved, more than brain fever form also ".Cold person, cold manifestation due to yang deficiency also, the nose being the orifice to the lung, lung-QI connecting with the nose, lung sun and can know good and foul smells.Weakness due to chronic disease, by gas and sun, the imbalance of lung sun, nose key loses temperature, can not declare tune, yang deficiency cold coagulation, the Yong Sai that cleans the street, is disease also.Improper diet and overtiredness, impairing the spleen and stomach, clear sun loses and rises, and nose loses gentle, and nasal sinusitis is done also." Treatise on the spleen and stomach " thinks taste void, and nine orifices is obstructed." Longevity and Life Preservation " says " rhinorrhea with clear discharge, heals for a long time and not, is into sinusitis with purulent discharge, must damage Yuanyang because of side ".Yuanyang person, kidney yang also, is led in brain on nose key, and kidney governing bones marrow fills in brain, and chamber is careless, and consumption essence is damaged cloudy, the deficiency of YIN and sun, kidney yang virtual loss, lung gold loses temperature, and lung cold brain is cold, and here yang deficiency nasal sinusitis is done.This " snivel person, the cold lung cold of brain due to " that " dialectical record " said.Clinical manifestation is: rhinorrhea with clear discharge, and the white amount of color is many, without nose but feel there is fishy smell, has a stuffy nose obstructed, anosmia, slightly meet the wind and cold watery nasal discharge of having a stuffy nose and increase the weight of, complexion is turned white, the spontaneous perspiration of breathing hard, or double loose stool, or spinal column acid is cold, extremity are not warm, pale tongue, and white and thin fur, deficient pulse is unable.

The traditional Chinese medical science is flexible and changeable to this sick Therapeutic Method, and several different methods is mainly permeated following theory: warming lung for dispelling cold benefiting QI for strengthening the superficies, replenishing QI to invigorate the spleen yang invigorating are sensible, warming and recuperating the kidney-YANG reinforces the kidney improving inspiration by invigorating kidney-QI.The traditional Chinese medical science is placed on this disease under this overall background of body, patient is carried out dialectical, selects pointedly suitable Chinese medicine composition prescription, to reach the effect of " cutting the garment according to the figure ".

Western medicine treatment rhinitis has very strong targeting, mechanism of action and link clear and definite, and curative effect is fast and remarkable, but the control of symptom too relies on medicine, and relapse rate is high.Western medical treatment is just in " control symptom ", instead for the treatment of disease, is not more the functional status of adjusting body; Be in addition " compacting " of process towel in morbidity, instead of carry out " adjustment " and " dredging " in the source of disease; Therefore there is the poor problem of high relapse rate and late result.Chinese traditional treatment rhinitis is on the basis of dialectical, Overall View and perpetual motion idea, carries out individuation, diagnosis and treatment targetedly.On macroscopic view and global basis, hold Therapeutic Principle, thereby avoid the drawback of " treat the head when the head aches, foot bitterly cure foot ", not only can control symptom and more take into account the treatment of the cause of disease, so late result is better.

Summary of the invention

The object of this invention is to provide the sensible Chinese medicine composition of a kind of cold expelling;

Another object of the present invention is to provide the sensible Chinese medicine composition preparation method of a kind of cold expelling.

The object of the invention is to realize by following technical scheme:

The Chinese medicine composition that cold expelling of the present invention is sensible is to be prepared from by the raw material of following weight portion:

Radix Astragali 20-35 part, Fructus Liquidambaris 20-35 part, Radix Angelicae Dahuricae 20-30 part, Fructus Psoraleae 10-20 part, Fructus Schisandrae Chinensis 10-20 part, Radix Rehmanniae Preparata 5-15 part, Bulbus Allii Fistulosi 5-15 part, Flos Magnoliae 5-15 part, Rhizoma Acori Graminei 5-15 part, Herba Asari 3-8 part, Fructus Xanthii 3-8 part, Ramulus Cinnamomi 3-8 part, Radix Platycodonis 3-8 part, Radix Glycyrrhizae Preparata 3-8 part.

Preferably, be to be prepared from by the raw material of following weight portion:

30 parts of the Radixs Astragali, 30 parts of Fructus Liquidambaris, 25 parts of the Radixs Angelicae Dahuricae, 15 parts of Fructus Psoraleaes, 15 parts of Fructus Schisandrae Chinensis, 10 parts of Radix Rehmanniae Preparata, 10 parts of Bulbus Allii Fistulosi, 10 parts of Flos Magnoliaes, 10 parts of Rhizoma Acori Graminei, 5 parts of Herba Asaris, 5 parts of Fructus Xanthii, 5 parts of Ramulus Cinnamomi, 5 parts of Radix Platycodoniss, 5 parts of Radix Glycyrrhizae Preparatas.

Below crude drug source of the present invention:

The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Spring, Qiu Erji excavate, and remove fibrous root and root head, dry.[nature and flavor with return through] are sweet, tepor.Return lung, spleen channel.[function with cure mainly] tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promotes the production of body fluid and nourishes blood, the stagnant blood stasis dispelling of row, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, hemiplegia, arthralgia pain numbness, carbuncle is difficult bursts, and bursts and does not hold back for a long time.

Fructus Liquidambaris: be the drying and ripening infructescence of Hamamelidaceae Plants Chinese sweet gum Liquidambar formosana Hance.Gather after fruit maturation winter, removes impurity, dry.[nature and flavor with return through] hardship, flat.Return liver, kidney channel.[function with cure mainly] dispelling, collateral-activating, diuretic, stimulates the menstrual flow.For arthralgia, numb spasm, edema distension, breast is few, amenorrhea.

The Radix Angelicae Dahuricae: be the dry root of samphire Radix Angelicae Dahuricae Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f. or Radix angelicae dahuricae Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.var.formosuna (Boiss.) Shan et Yuan.When leaf is yellow between summer, autumn, excavate, remove fibrous root and silt, dry or cold drying.[nature and flavor with return through] are pungent, temperature.Return stomach, large intestine, lung meridian.[function with the cure mainly] cold expelling that induces sweat, wind-expelling pain-stopping, a surname's clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, toothache, leukorrhagia, skin infection swells and ache.

Fructus Psoraleae: be the dry mature fruit of legumes psoraleae Psoralea corylifolia L..The infructescence of gathering when fruit maturation autumn, dries, and rubs fruit, removes impurity.[nature and flavor with return through] are pungent, bitter, temperature.Return kidney, spleen channel.[function with cure mainly] warming the kidney to activate YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha.

Fructus Schisandrae Chinensis: be the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill..Practise and claim " Radix Schisandrae Bicoloris ".Pluck when fruit maturation autumn, dry or steam after dry, remove carpopodium and impurity.[nature and flavor with return through] acid, sweet, temperature.Return lung, the heart, kidney channel.[function with cure mainly] restrains astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous sweating, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, palpitation and insomnia.

Radix Rehmanniae Preparata: be the Preparation process product of Radix Rehmanniae.Radix Rehmanniae is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..[nature and flavor with return through] are sweet, tepor.Return liver, kidney channel.[function with the cure mainly] YIN nourishing of enriching blood, beneficial essence is filled out marrow.For blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, interior-heat is quenched one's thirst, dizzy, tinnitus, chin is sent out early white.

Bulbus Allii Fistulosi: the bulb of the nearly root of liliaceous plant Herba Alii fistulosi (Allium fistulosum L.).All there is plantation China various places, can adopt at any time.After excavating, cut fibrous root and leaf, peel off adventitia, using fresh herb.[curing mainly] cold; YIN-cold stomachache; Constipation and anuresis; Dysentery; Sore, carbuncle and painful swelling; Abdominal pain due to worm stagnation.[nature and flavor] acrid in the mouth; Warm in nature.

Flos Magnoliae: be the dry flower of Magnoliacea plant Flos Magnoliae Magnolia biondii Pamp., Magnolia denudata Magnolia denudate Desr. or Flos Magnoliae Magnolia sprengeri Pamp..When flower is not open at the beginning of last month of spring in winter, gather, except discarding stalk, dry in the shade.[nature and flavor with return through] are pungent, temperature.Attach to the lung and stomach meridians.[function with cure mainly] dispersing wind and cold, clearing the nasal passage.For headche due to wind-cold, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis.

Rhizoma Acori Graminei: be the dry rhizome of acorus gramineus araceae plant Acorus tatarinowii Schott.Autumn, two seasons of winter excavate, and remove fibrous root and silt, dry.[nature and flavor with return through] are pungent, bitter, temperature.GUIXIN, stomach warp.[function with the cure mainly] eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae, removing dampness appetizing.For coma epilepsy, forgetful insomnia, Hiccough and deaf, gastral cavity painful abdominal mass is not hungry, mouthful dysentery of keeping silent.

Herba Asari: be dry root and the rhizome of aristolochiaceae plant Herba Asari Asarum heterotropoides Fr.Schmidt val.Mandshuricum (Maxim.) Kitag., Seoul Herba Asari Asarum sieboldii Miq.Var.seoulense Nakai or magnificent Herba Asari Asarum sieboldiiMiq..The first two is planted to practise and claims " Herba Asari ".Summer fructescence or early autumn excavate, and Ex-all aerial parts and silt, dry in the shade.[nature and flavor with return through] are pungent, temperature.GUIXIN, lung, kidney channel.[function with cure mainly] expelling wind and cold, wind-expelling pain-stopping, sensible, warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.

Fructus Xanthii: be the fruit of the drying and ripening band involucre of feverfew Herba Xanthii Xanthium sibiricum Patr..Gather when fruit maturation autumn, dry, except impurity such as destemming, leaves.Herb also can be used as medicine.Pungent, bitter, temperature; Poisonous.Return lung meridian.Expelling pathogenic wind from the body surface, a surname's clearing the nasal passage, removing damp and stopping pain.For headche due to wind-cold, nasal sinusitis watery nasal discharge, rubella pruritus, arthralgia chiefly caused by damp pathogen contracture.When main expelling pathogenic wind from the body surface is controlled main symptom, specially work, in clearing the nasal passage, is removed the obstinate accompanied symptoms in this exterior syndrome, and it can also removing damp and stopping pain, the card that treatment affection of exogenous wind-cold is held concurrently the tired resistance of folder damp.

Ramulus Cinnamomi: be the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Spring, Xia Erji gather, and except defoliation, dry, or section are dried.[nature and flavor with return through] acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.[function with cure mainly] diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Radix Platycodonis: be the dry root of Campanulaceae Radix Platycodonis Platycodon grandiflorum (Jacq.) A.Dc..Spring, Qiu Erji excavate, and clean, and remove fibrous root, take advantage of and freshly peel off crust or do not remove crust, dry.[nature and flavor with return through] are bitter, pungent, flat.Return lung meridian.[function with cure mainly] lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia hoarseness, lung abscess vomiting pus.

Radix Glycyrrhizae Preparata: be the Preparation process product of Radix Glycyrrhizae.Radix Glycyrrhizae is dry root and the rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflate Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..[nature and flavor with return through] are sweet, flat.GUIXIN, lung, spleen, stomach warp.[function with cure mainly] spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, tired weak, severe palpitation, irregularly intermittent and regularly intermittent pulse.

Another aspect of the present invention has been to provide the preparation method of the active component of Chinese medicine composition of the present invention, and the method is the ethanol extraction that adopts water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:

Scheme one: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, and merge extractive liquid, filters, the clear paste that when filtrate is concentrated into 70-80 DEG C, relative density is 1.10-1.25, obtains described active component.

Scheme two: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filters the clear paste that when filtrate is concentrated into 70-80 DEG C, relative density is 1.05-1.20, add ethanol, making containing alcohol amount is 40-70%, leaves standstill 12-24 hour, filters, the extractum that when filtrate is concentrated into 70-80 DEG C, relative density is 1.10-1.25, obtains described active component.

Scheme three: get whole medical materials, use 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-3 hour, and merge extractive liquid, filters, the extractum that when filtrate is concentrated into 60-80 DEG C, relative density is 1.10-1.25, obtains described active component.

The Chinese medicine composition that cold expelling of the present invention is sensible, can coordinate with pharmaceutically acceptable carrier, makes various conventional external preparation, as ointment, unguentum, liniment, lotion, gel, powder etc.

Pharmaceutically acceptable carrier of the present invention includes but not limited to following:

Diluent: distilled water, ethanol etc.

Cosolvent: the polyhydric alcohol such as glycerol, sorbitol.

Antiseptic: benzoic acid, sodium benzoate, sorbic acid and salt thereof, propanoic acid, parabens, ethylparaben etc.

Greasing base: vaseline, liquid Paraffin, lanoline, Cera Flava, animal oil, vegetable oil, glyceryl monostearate, octadecanol etc. and composition thereof,

Water-soluble base: glycerol, sodium alginate, carbopol resin, starch gelatin, methylcellulose, sodium carboxymethyl cellulose, Polyethylene Glycol, polyvinyl alcohol.

For example, it can be prepared as various common exterior-applied formulations by one of following method:

Method 1:(is soft) unguentum

Get scheme one to one of scheme three gained active component, add unguentum to commonly use adjuvant, production method is prepared into unguentum of the present invention routinely.

The conventional accessory package of above-mentioned unguentum is drawn together one of greasing base, water-soluble base, antiseptic, penetration enhancer or whole.

Method 2: lotion

Get scheme one to one of scheme three gained active component, add lotion to commonly use adjuvant, production method is prepared into lotion of the present invention routinely.

The conventional adjuvant of above-mentioned lotion comprises one of diluent, antiseptic, cosolvent, penetration enhancer or whole.

Method 3: gel

Get scheme one to one of scheme three gained active component, add gel to commonly use adjuvant, production method is prepared into gel of the present invention routinely.

The conventional adjuvant of above-mentioned gel comprises one of water-soluble base, antiseptic, penetration enhancer or whole.

Method 4: powder

Get whole medical materials, clean, dry, pulverize into coarse powder, sieve, obtain powder of the present invention.

The conventional adjuvant of above-mentioned mixture comprises one of correctives, antiseptic or whole.

The traditional Chinese medical science is generally divided into three types by " nasal sinusitis ": the first typing: the deficiency of the lung is stopped drink type, controls suitable invigorating the lung and strengthening defensive QI, resolving fluid-retention with drugs of warm nature; The second typing: qi-deficiency type, comprise insufficiency of lung-QI, deficiency of kidney-QI, deficiency of kidney-QI, treatment is taking QI invigorating as main; The third typing: lung qi asthenic cold type, control taking warming lung for dispelling cold, benefiting QI for strengthening the superficies, harmonizing yingfen and weifen as main.Radix Astragali tonifying Qi and lifting yang in we, closes Radix Platycodonis dispersing and elevation lung qi, helps sun clearly to rise; Herba Asari warming lung for dispelling cold; Rhizoma Acori Graminei, Fructus Liquidambaris inducing resuscitation dredging collateral; Radix Rehmanniae Preparata temperature male wind-supplying kidney; Fructus Xanthii, Flos Magnoliae warming the lung are sensible; The Radix Angelicae Dahuricae, Ramulus Cinnamomi, Bulbus Allii Fistulosi expelling wind and cold, diaphoresis expelling pathogenic factors from muscles; Fructus Schisandrae Chinensis, the replenishing essence of Fructus Psoraleae the kidney warming, beneficial brain stops tears; Radix Glycyrrhizae Preparata spleen reinforcing stomach function regulating, coordinating the actions of various ingredients in a prescription.Use we, from basic and enter, interior temperature compensation lung spleen, the kidney-replenishing virtual loss of holding concurrently, thereby stop turbid sensible, make lung sun adjust suitable, nose key must be logical, thereby wait all diseases of nasal sinusitis that cause and eliminated by cold.Technical solution of the present invention meets the mechanism of tcm treatment according to syndrome differentiation, bases oneself upon the origin of disease, reasonable recipe science.

The sensible Chinese medicine composition of a kind of cold expelling provided by the invention has the following advantages:

1, the Chinese medicine composition by the sensible treatment rhinitis of cold expelling provided by the invention is safe and effective, has temperature compensation lung spleen, stops turbid sensible effect, and all diseases of nasal sinusitis that caused by cold time etc. are had to better therapeutic effect.

2, it is satisfactory for result that the present invention makes external preparation treatment rhinitis, and while particularly using externally used paste treatment, effective percentage is remarkable especially, and clinical effectiveness shows that total effective rate is 90%.Its reason is as follows: nasal cavity is made up of polylith cartilage, lacks nerve and blood vessel on first bone, and the effective ingredient that oral drugs absorb the drug by blood circulation entirely just can reach therapeutic purposes.So the medicine of how good oral medication rhinitis is all difficult to the reason of proving effective, nasal cavity is again the main thoroughfare of cold and hot air exchange, cavity temperature is all higher than epidermis oxter, general liquid medicine spray nose treatment inflammatory cacorhinia, also can only slightly alleviate symptom for the moment, reason is that the liquid medicine that enters nasal cavity can be become moisture rapidly by the high temperature of nasal cavity and evaporate with air-flow, the unendurable reason of effect when this is externally applied spray treatment rhinitis.The sensible rhinitis unguentum of cold expelling of the present invention can directly enter nasal cavity focus, and the impact of the hot-air of not catching a cold is played antiinflammatory, sterilization, toxin expelling, sensible, reparative regeneration settles at one go, and the treatment feature for the treatment of both the principal and secondary aspects of a disease, thoroughly cures rhinitis, and effect is better.

3, Chinese medicine composition method of the present invention is easy, and safety, without obvious toxic and side effects, is conducive to clinical expansion and research.

Detailed description of the invention

Further illustrate the present invention below by embodiment.It should be understood that embodiments of the invention are for the present invention instead of limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.

Embodiment 1: ointment

Get Radix Astragali 30g, Fructus Liquidambaris 30g, Radix Angelicae Dahuricae 25g, Fructus Psoraleae 15g, Fructus Schisandrae Chinensis 15g, Radix Rehmanniae Preparata 10g, Bulbus Allii Fistulosi 10g, Flos Magnoliae 10g, Rhizoma Acori Graminei 10g, Herba Asari 5g, Fructus Xanthii 5g, Ramulus Cinnamomi 5g, Radix Platycodonis 5g, Radix Glycyrrhizae Preparata 5g, above-mentioned whole medical material extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid,, filter the extractum that when filtrate is concentrated into 80 DEG C, relative density is 1.10; Get salicylic acid 8g, stearic acid 15g, glyceryl monostearate 13g, white vaseline 2g, lanoline 4g, liquid paraffin 8g, Tween 80 0.6g, distilled water adds to 160g, makes emulsifying agent substrate by conventional method, adds above-mentioned extractum, makes ointment.

Embodiment 2: unguentum

Get Radix Astragali 30g, Fructus Liquidambaris 20g, Radix Angelicae Dahuricae 30g, Fructus Psoraleae 20g, Fructus Schisandrae Chinensis 20g, Radix Rehmanniae Preparata 15g, Bulbus Allii Fistulosi 5g, Flos Magnoliae 5g, Rhizoma Acori Graminei 15g, Herba Asari 3g, Fructus Xanthii 3g, Ramulus Cinnamomi 8g, Radix Platycodonis 3g, Radix Glycyrrhizae Preparata 8g, by above-mentioned whole medical materials alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times of medical material total amount, 8 times, extraction time is respectively 34 hours, 2 hours, merge extractive liquid, filter, the extractum that when filtrate is concentrated into 80 DEG C, relative density is 1.10, add polyoxyethylene sorbitan monoleate 20ml, glycerin gelatine 2000g is incubated 55 DEG C and stirs, cooling, obtain unguentum of the present invention.

Embodiment 3: gel

Get Radix Astragali 30g, Fructus Liquidambaris 20g, Radix Angelicae Dahuricae 30g, Fructus Psoraleae 15g, Fructus Schisandrae Chinensis 10g, Radix Rehmanniae Preparata 15g, Bulbus Allii Fistulosi 10g, Flos Magnoliae 5g, Rhizoma Acori Graminei 15g, Herba Asari 5g, Fructus Xanthii 3g, Ramulus Cinnamomi 8g, Radix Platycodonis 5g, Radix Glycyrrhizae Preparata 3g, by above-mentioned whole medical materials, extracting in water 2 times, each amount of water is equivalent to respectively 12 times of medical material gross weight, 10 times, each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filter, filtrate is concentrated into the clear paste that at 80 DEG C, relative density is 1.05, add ethanol, making containing alcohol amount is 70%, leave standstill 12 hours, filter, the extractum that when filtrate is concentrated into 70 DEG C, relative density is 1.25, get carbomer 9408g, glycerol 80g, propylene glycol 80g, ethanol 160g, ethyl hydroxybenzoate 0.5g, triethanolamine 7.5g, add deionized water to 800g, be made into according to a conventional method gel-type vehicle, add above-mentioned active component, make according to a conventional method gel, obtain gel of the present invention.

Embodiment 4: gel

Get Radix Astragali 30g, Fructus Liquidambaris 20g, Radix Angelicae Dahuricae 30g, Fructus Psoraleae 15g, Fructus Schisandrae Chinensis 10g, Radix Rehmanniae Preparata 15g, Bulbus Allii Fistulosi 10g, Flos Magnoliae 5g, Rhizoma Acori Graminei 15g, Herba Asari 5g, Fructus Xanthii 3g, Ramulus Cinnamomi 8g, Radix Platycodonis 5g, Radix Glycyrrhizae Preparata 3g by above-mentioned whole medical materials alcohol reflux 3 times, each concentration of alcohol is respectively 80%, 60%, 40%, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, extraction time is respectively 3 hours, 2 hours, 1 hour, merge extractive liquid,, filter the extractum that when filtrate is concentrated into 70 DEG C, relative density is 1.25; Get carbomer 9409g, glycerol 90g, propylene glycol 90g, ethanol 180g, ethyl hydroxybenzoate 0.6g, triethanolamine 7.2g, add deionized water to 800g, be made into according to a conventional method gel-type vehicle, add above-mentioned active component, make according to a conventional method gel, obtain gel of the present invention.

Embodiment 5: lotion

Get Radix Astragali 20g, Fructus Liquidambaris 20g, Radix Angelicae Dahuricae 20g, Fructus Psoraleae 10g, Fructus Schisandrae Chinensis 10g, Radix Rehmanniae Preparata 5g, Bulbus Allii Fistulosi 5g, Flos Magnoliae 5g, Rhizoma Acori Graminei 5g, Herba Asari 3g, Fructus Xanthii 3g, Ramulus Cinnamomi 3g, Radix Platycodonis 3g, Radix Glycyrrhizae Preparata 3g, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid,, filter the extractum that when filtrate concentrates 60 DEG C, relative density is 1.25; In extractum, add water to 10 times of the crude drug amount that feeds intake, add the benzoic acid of medicinal liquid gross weight 0.15%, stir, filter, obtain lotion of the present invention.

Embodiment 6: unguentum

Get Radix Astragali 35g, Fructus Liquidambaris 35g, Radix Angelicae Dahuricae 30g, Fructus Psoraleae 20g, Fructus Schisandrae Chinensis 20g, Radix Rehmanniae Preparata 15g, Bulbus Allii Fistulosi 15g, Flos Magnoliae 15g, Rhizoma Acori Graminei 15g, Herba Asari 8g, Fructus Xanthii 8g, Ramulus Cinnamomi 8g, Radix Platycodonis 8g, Radix Glycyrrhizae Preparata 8g extracting in water 3 times, three amount of water are equivalent to respectively 12 times of medical material gross weight, 8 times, 6 times, 3 hours respectively each extraction time, 2 hours, 1 hour, merge extractive liquid, filter, the clear paste that when filtrate is concentrated into 70 DEG C, relative density is 1.20, add ethanol, making containing alcohol amount is 40%, leave standstill 24 hours, filter, the extractum that when filtrate is concentrated into filtrate and is concentrated into 70 DEG C, relative density is 1.10, get the semi-synthetic fatty acid ester of 2 times of extractum weight, heating in water bath fusing, stirs with extractum, obtains unguentum of the present invention.

Embodiment 7: lotion

Get Radix Astragali 35g, Fructus Liquidambaris 20g, Radix Angelicae Dahuricae 25g, Fructus Psoraleae 20g, Fructus Schisandrae Chinensis 10g, Radix Rehmanniae Preparata 10g, Bulbus Allii Fistulosi 15g, Flos Magnoliae 5g, Rhizoma Acori Graminei 10g, Herba Asari 8g, Fructus Xanthii 3g, Ramulus Cinnamomi 5g, Radix Platycodonis 8g, Radix Glycyrrhizae Preparata 3g, by above-mentioned whole medical material extracting in waters 3 times, three amount of water are respectively 12 times of medical material gross weight, 8 times, 6 times, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filter, the clear paste that when filtrate is concentrated into 70 DEG C, relative density is 1.25, finally add water to 8 times of the crude drug amount that feeds intake, add the ethyl hydroxybenzoate of medicinal liquid gross weight 0.1%, stir, filter, obtain lotion of the present invention.

Embodiment 8: powder

Get Radix Astragali 30g, Fructus Liquidambaris 30g, Radix Angelicae Dahuricae 25g, Fructus Psoraleae 15g, Fructus Schisandrae Chinensis 15g, Radix Rehmanniae Preparata 10g, Bulbus Allii Fistulosi 10g, Flos Magnoliae 10g, Rhizoma Acori Graminei 10g, Herba Asari 5g, Fructus Xanthii 5g, Ramulus Cinnamomi 5g, Radix Platycodonis 5g, Radix Glycyrrhizae Preparata 5g, be ground into coarse powder, sieve, obtain powder of the present invention.

Clinical treatment is summed up

1.1 physical data

In January, 2010～2012 are accepted chronic rhinitis patient 200 examples for medical treatment year February, wherein male 120 examples, and female's 80 examples, at 10～70 years old age, medical history 0.5～40 year, had all been used antibiotics before treatment, and the therapeutic effect such as operative treatment, vasoconstrictor are not good.Patient is divided into two groups at random, learns by statistics processing for two groups at aspects such as age, sex, the course of disease, typings, and there was no significant difference (P>0.05), has comparability.

1.2 diagnostic criterias:

Diagnosis basis is taking People's Republic of China's Chinese medicine industry standard " disease of tcm Standardization of diagnosis and curative effect " as standard.

1.3, Therapeutic Method

Treatment group: embodiment 1 ointment.With being about 2-8cm, the flat swab stick of wide about 1cm, evenly coats embodiment 1 ointment, and little absorbent-cotton rod is filled in to nostril, as far as possible toward in, be evenly applied to the about 15-30 minute in concha nasalis inferior front and rear part, ointment is fully contacted with concha nasalis inferior mucosa.Extract after swab stick, the cotton filling of nasal cavity applied medicine nostril is changed once for 5 minutes.

Matched group: oral BIYANKANG sheet, Foshan Dezhong Pharmaceutical Co., Ltd., each 4, every day three times.

1.4 observation index

Taking symptom, sign as observation index foundation.Symptom is mainly observed nasal obstruction, pus nasal mucus, olfactory function situation, and sign is mainly observed nasal mucosa and had or not hyperemia, concha nasalis to have or not hypertrophy.

1.5, curative effect judgement

Efficacy assessment standard: according to subjective symptoms, curative effect is divided three classes.

1. cure: transference cure, CT, x-ray check that conscious ventilation is good without abnormal, nothing or few nasal mucus.Concha nasalis inferior size, mucosa color and luster recover normal, headache, dizzy transference cure.Follow up a case by regular visits to 2 years without recurrence.

2. take a turn for the better: symptom is clearly better, ventilation improves, and occasionally has nasal mucus, and concha nasalis inferior volume dwindles before treating, and does not return to normal size, and headache and dizzy symptom alleviates.

3. invalid: nasal airflow is without improvement, and nasal mucus is many, headache, dizzy symptom and sign is without alleviating.

2 therapeutic outcomes

Four comparisons of rhinitis after 2.1 treatments, in table 1.

Before and after table 1 liang group treatment, rhinitis quality of life changes relatively (each 100 examples)

Note: 1. compare quality of life before and after the treatment of this group;

2. after treatment group and treatment of control group, compare curative effect.

Table 1 result shows: before and after randomized controlled treatment, quality of life is not improved.Patient's headache after treatment group treatment, migraine, nasal obstruction, etc. phenomenon obviously improve, watery nasal discharge degree alleviates, and before treatment, relatively has significant difference (P<0.05) or significant difference (P<0.01) extremely.

Curative effect comparison before and after 2.2 liang of group patient treatments, in table 2.

Curative effect comparison before and after table 2 liang group treatment

Note: compared with matched group, * P<0.01

Table 2 result shows: the application embodiment of the present invention 1 therapeutic effect is remarkable, and cure rate reaches 90%.After treatment, follow up a case by regular visits to 1 year, have 5 routine private prosecutions pus tears after flu to increase, headache and dizzy, reused after 1 course for the treatment of of the embodiment of the present invention 1 ointment, and all diseases disappear.It is slow that the oral drug for treating rhinitis of matched group is compared onset, and total effective rate is low, has utmost point significant difference compared with treatment group.

3 conclusions: with matched group comparison, the embodiment of the present invention 1.

Conclusion: headache after oral drug for treating rhinitis treatment, migraine alleviate to some extent; The diseases such as clear nasal mucus, yellow nasal mucus, pus nasal mucus, rhinocnesmus, nasal obstruction, sneeze reduce to some extent and alleviate; Olfactory function, without obvious recovery, shows that oral medicine is undesirable to acute or chronic rhinitis curative effect, can not well reach the effect for the treatment of both the principal and secondary aspects of a disease, and easily recurrence after drug withdrawal.Externally used paste of the present invention can effectively alleviate patient and wait due to cold all diseases of rhinitis that cause, and the present invention has utmost point significant difference compared with matched group, and the clinical use of prompting the present invention has extremely significant sensible effect of cold expelling, can effectively treat sympotoms caused by cold factors chronic rhinitis.

model case

What certain, female, 45 years old.Patient suffers from allergic rhinitis, sinusitis more than 25 years, often rhinocnesmus, snivel, sneeze.The medicinal ointment therapy that uses embodiment 1, each 2 grams, nasal cavity medication every day in left and right once, is flowed out a large amount of dense tears after medication, ventilates comfortable after half an hour, 15 days course for the treatment of, treats 4 courses for the treatment of, and 60 days, rhinitis recovery from illness, followed up a case by regular visits to and has no recurrence in 1 year.

Thank certain, man, 55 years old.Patient suffers from allergic rhinitis more than 14 years, repeatedly nasal obstruction, rhinorrhea.Use embodiment 2 medicinal ointment therapies, each 2 grams, nasal cavity each medication every day in left and right once, is removed the residual dense tears of a large amount of nasal cavities after medication, ventilates immediately comfortable, 15 days course for the treatment of, treats for 2 courses for the treatment of, and 30 days, rhinitis recovery from illness, followed up a case by regular visits in two years and have no recurrence.

Lee, man 73 years old, suffers from sinusitis, nasal conchae hypertrophy 30 years, uses embodiment 3 gel treatments, each 2 grams, medication every day of left and right nasal cavity once, after medication after three days without nasal obstruction phenomenon, 15 days course for the treatment of, treat 4 courses for the treatment of, after 60 days, rhinitis recovery from illness, did not recur in 3 years.

Deep certain, female, 64 years old, suffers from sinusitis, nasal conchae hypertrophy 15 years, use embodiment 4 gel treatments, each 2 grams, nasal cavity medication every day in left and right once, is ventilated comfortable in after medication second day immediately, 15 days course for the treatment of, treating for 3 courses for the treatment of is after 45 days, and rhinitis recovery from illness, follows up a case by regular visits in two years and have no recurrence.

Wei, man, 12 years old, suffer from sinusitis 3 years, use embodiment 6 unguentum treatments, each 1 gram, medication every day of left and right nasal cavity once, it is comfortable that ventilated immediately the same day by medication, and 15 days course for the treatment of, after 2 courses for the treatment of of treatment, 30 days, sinusitis recovery from illness, had no recurrence for 3 years so far.

Although, above use general explanation, detailed description of the invention and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.

Claims

1. the sensible Chinese medicine composition of cold expelling, is characterized in that it is to be prepared from by the raw material of following weight portion: Radix Astragali 20-35 part, Fructus Liquidambaris 20-35 part, Radix Angelicae Dahuricae 20-30 part, Fructus Psoraleae 10-20 part, Fructus Schisandrae Chinensis 10-20 part, Radix Rehmanniae Preparata 5-15 part, Bulbus Allii Fistulosi 5-15 part, Flos Magnoliae 5-15 part, Rhizoma Acori Graminei 5-15 part, Herba Asari 3-8 part, Fructus Xanthii 3-8 part, Ramulus Cinnamomi 3-8 part, Radix Platycodonis 3-8 part, Radix Glycyrrhizae Preparata 3-8 part.

2. the sensible Chinese medicine composition of cold expelling as claimed in claim 1, is characterized in that it is to be prepared from by the raw material of following weight portion: 30 parts of the Radixs Astragali, 30 parts of Fructus Liquidambaris, 25 parts of the Radixs Angelicae Dahuricae, 15 parts of Fructus Psoraleaes, 15 parts of Fructus Schisandrae Chinensis, 10 parts of Radix Rehmanniae Preparata, 10 parts of Bulbus Allii Fistulosi, 10 parts of Flos Magnoliaes, 10 parts of Rhizoma Acori Graminei, 5 parts of Herba Asaris, 5 parts of Fructus Xanthii, 5 parts of Ramulus Cinnamomi, 5 parts of Radix Platycodoniss, 5 parts of Radix Glycyrrhizae Preparatas.

3. the Chinese medicine composition as described in claim 1-2 any one, the active component that it is characterized in that it is to adopt the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.

4. Chinese medicine composition as claimed in claim 3, the active component that it is characterized in that it is prepared from by the following method: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, and merge extractive liquid, filters, the clear paste that when filtrate is concentrated into 70-80 DEG C, relative density is 1.10-1.25, obtains described active component.

5. Chinese medicine composition as claimed in claim 3, the active component that it is characterized in that it is prepared from by the following method: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filter, the clear paste that when filtrate is concentrated into 70-80 DEG C, relative density is 1.05-1.20, adds ethanol, and making containing alcohol amount is 40-70%, leave standstill 12-24 hour, filter, the extractum that when filtrate is concentrated into 70-80 DEG C, relative density is 1.10-1.25, obtains described active component.

6. Chinese medicine composition as claimed in claim 3, the active component that it is characterized in that it is prepared from by the following method: get whole medical materials, with 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-3 hour, and merge extractive liquid, filters, the extractum that when filtrate is concentrated into 60-80 DEG C, relative density is 1.10-1.25, obtains described active component.

7. the sensible Chinese medicine composition of cold expelling, comprises acceptable carrier in Chinese medicine composition that the cold expelling of any one in claim 1-2 is sensible and pharmaceuticals industry.