CN103920058A - Traditional Chinese medicine preparation for treating headache and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine preparation for treating headache. Sending up the lucid yang is achieved by the adoption of pueraria, ligusticum wallichii, radix paeoniae alba and salvia miltiorrhiza , qi of the taste lucid yang is inspired and moves upwards to the brain, the effects of blood invigorating, blood stasis removing, liver yang stabilizing, nerves calming, will calming, anxious relieving and pain stopping are achieved, the above drugs serve as the sovereign drugs; chinese thorowax roots, nacre, rhizoma gastrodiae, scorpion, rhizoma corydalis, asarum sieboldii miq, angelica dahurica, Chinese ligusticum rhizome, mentha and chrysanthemums serve as the assistant drugs, the effects of soothing liver-qi stagnation, Yang spirit promoting, wind calming and spasm stopping, and nerves activating and pain stopping are achieved; radix cyathulae, peach seeds, safflowers, cortex moutan, szechwan chinaberry fruit, cassia twigs, notopterygium incisum, clematis roots, and white mustard seeds are the adjuvant drugs, the effects of coordinating, strengthening the treatment effects of the sovereign drugs and the assistant drugs and restricting the toxic and side effects of other drugs are achieved; scutellaria baicalensis, bamboo shavings, towel gourd vegetable sponges, fructus cannabis and licorice roots are used for relaxing bowel, clearing heat and drying damp, dispelling wind, activating collaterals, stopping pain, coordinating the drug actions of the prescription, and guiding the drugs to reach directly the lesions. The traditional Chinese medicine prescription for treating the headache is simple and convenient in preparing technology, small in toxic and side effect, convenient to dose, easy to manufacture, low in cost, capable of reaching directly to the lesions and short in curing time, and does not have a relapse after curing.

Description

A kind of Chinese medicine preparation for the treatment of headache and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine preparation for the treatment of headache and preparation method thereof.

Background technology

The at present non-drug therapy of functional headache is mainly divided into two kinds, and a kind of is " naturopathy ", comprises that acupuncture and moxibustion treatment, massage therapy, neuromuscular electrical stimulation, electroexcitation therapy, meridians are led to bring treatment etc. under control; Another kind is " relaxation therapy ", and it mainly, by controlling consciously or regulating the psychology physiological of self movable, reduces body arousal level to reach as the complementary therapy of Drug therapy, makes people's ataraxy of flaccid muscles, thereby alleviates the Therapeutic Method of headache.

Summary of the invention

Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, new drug with low cost.The present invention is Chinese medicine preparation, can reach suppressing the hyperactive liver and subsiding YANG, dredge the meridian passage, blood-activating and qi-promoting, the effect of resolving depression pain relieving.The present invention is under the guidance of Basic Theories of Chinese Medicine, and determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs combines with differentiation of syndromes of meridian, adopts the Chinese crude drug of different properties, carried out science compatibility, the side of being combined into, we have safe and effective, and side effect is little, preparation is simple, through focus, healing time is short, after curing, is difficult for the features such as recurrence, by a large amount of clinical practice cases, obtained satisfied effect.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of headache, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: Radix Puerariae 15-30 part, Radix Paeoniae Alba 30-45 part, Rhizoma Gastrodiae 10-15 part, Radix Angelicae Dahuricae 10-15 part, Radix Bupleuri 15-20 part, Fructus Toosendan 10-15 part, Rhizoma Corydalis 15-20 part, Concha Margaritifera 15-30 part, Ramulus Cinnamomi 6--10 part, Radix Clematidis 10-15 part, Semen Sinapis Albae 10-15 part, Retinervus Luffae Fructus 10-15 part, Semen Persicae 10-15 part, Flos Carthami 5-15 part, Rhizoma Chuanxiong 30-45 part, Radix Cyathulae 15-20 part, Flos Chrysanthemi 10-15 part, Radix Scutellariae 10-15 part, Cortex Moutan 10-15 part, Rhizoma Et Radix Notopterygii 6-10 part, Scorpio 6-10 part, Caulis Bambusae In Taenia 10-15 part, Radix Salviae Miltiorrhizae 30-45 part, Fructus Cannabis 15-20 part, this 10-15 of Gao part, Herba Asari 3-6 part, Herba Menthae 6-10 part, Radix Glycyrrhizae 6-10 part.

The Chinese medicine preparation of described treatment headache, the ratio of weight and number of various crude drug can also be: Radix Puerariae 20-25 part, Radix Paeoniae Alba 32-40 part, Rhizoma Gastrodiae 12-14 part, Radix Angelicae Dahuricae 12-14 part, Radix Bupleuri 16-18 part, Fructus Toosendan 12-14 part, Rhizoma Corydalis 16-18 part, Concha Margaritifera 18-25 part, Ramulus Cinnamomi 7-9 part, Radix Clematidis 11-14 part, Semen Sinapis Albae 11-14 part, Retinervus Luffae Fructus 11-14 part, Semen Persicae 11-14 part, Flos Carthami 6-12 part, Rhizoma Chuanxiong 32-42 part, Radix Cyathulae 16-19 part, Flos Chrysanthemi 11-14 part, Radix Scutellariae 11-14 part, Cortex Moutan 11-14 part, Rhizoma Et Radix Notopterygii 7-9 part, Scorpio 7-9 part, Caulis Bambusae In Taenia 11-14 part, Radix Salviae Miltiorrhizae 32-42 part, Fructus Cannabis 16-19 part, this 11-14 of Gao part, Herba Asari 4-5 part, Herba Menthae 7-9 part, Radix Glycyrrhizae 7-9 part.

The Chinese medicine preparation of described treatment headache, the ratio of weight and number of various crude drug can also be: 22 parts of Radix Puerariaes, 35 parts of the Radix Paeoniae Albas, 13 parts, Rhizoma Gastrodiae, 13 parts of the Radixs Angelicae Dahuricae, 17 parts of Radix Bupleuri, 13 parts of Fructus Toosendans, 15 parts of Rhizoma Corydalis, 20 parts of Concha Margaritiferas, 8 parts of Ramulus Cinnamomi, 12 parts of Radix Clematidis, 12 parts of Semen Sinapis Albaes, 12 parts of Retinervus Luffae Fructuss, 12 parts, Semen Persicae, 10 parts, Flos Carthami, 38 parts of Rhizoma Chuanxiongs, 18 parts of Radix Cyathulaes, 13 parts of Flos Chrysanthemis, 13 parts of Radix Scutellariaes, 13 parts of Cortex Moutans, 8 parts of Rhizoma Et Radix Notopterygiis, 8 parts of Scorpios, 13 parts of Caulis Bambusae In Taenia, 35 parts of Radix Salviae Miltiorrhizaes, 18 parts of Fructus Cannabiss, these 13 parts of Gao, 4.5 parts of Herba Asaris, 8 parts of Herba Menthaes, 8 parts of Radix Glycyrrhizae.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of headache, and the preparation method that the dosage form of described Chinese medicine preparation is capsule comprises:

A, getting crude drug and add alcohol reflux 1 time, reclaim ethanol concentrating under reduced pressure and become extractum shape, is component 1;

B, medicinal residues decoct with water 2 times, merge decoction liquor, and filtering and concentrating is extractum shape, is component 2;

C, above-mentioned two kinds of extractum concentrate dryings are become to dry cream, co-grinding, adds dextrin, fill capsule.

In described step a, the 60-80% soak with ethanol 1-4 hour that weighting raw materials material can add 5-8 doubly to measure, reflux, extract, 1 time, above gets clear liquid decompression recycling ethanol and is concentrated into extractum shape, as component 1.

In described step b, medicinal residues can be soaked 0.5-2.5 hour, decoct 2 times, each 1-3 hour, merges decoction liquor, and 80-200 order filters, the 5000-10000 rev/min of supernatant after centrifugal, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000, ultrafiltrate concentrating under reduced pressure relative density is 1.30(60 ℃) extractum, as component 2.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of headache, and the preparation method that described Chinese medicine preparation dosage form is tablet comprises:

A, Flos Carthami, Flos Chrysanthemi and Herba Menthae are added to reflux, extract, in ethanol;

B, get the surplus stock in above-mentioned side again, decoct with water;

C, above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol concentrated sucking filtration absorption, obtain crude drug; Add dextrin or starch tabletting.

In described step a, Flos Carthami, Flos Chrysanthemi and Herba Menthae can be put into 10 times of amount ethanol, reflux, extract, 2 times, each 1～2 hour, merge extractive liquid,, standing, filter;

In described step b, surplus stock is put into 10 times of water gagings, decoct 2 times, each 0.5～2 hour, merge decoction liquor, standing, filter;

In described step c, above-mentioned two kinds of filtrates can be merged, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.08 (20 ℃); The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first use deionized water or the distilled water eluting of 10 times of resin column volumes, discard, use again 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, decompression recycling ethanol, and be condensed into thick paste, add starch or dextrin wet method granule processed, drying under reduced pressure, tabletting.

For solving the problems of the technologies described above, the present invention also provides a kind of pharmaceutical dosage form for the treatment of the Chinese medicine preparation of headache, and its pharmaceutical dosage form comprises: capsule, tablet, granule, honey pill agent, powder, sublimed preparation, injection, suppository, plaster, syrup, powder, pin powder or patch.

The Chinese medicine preparation that the present invention treats headache meets Chinese medical theory, with Radix Puerariae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae sending up the lucid YANG, and blood circulation promoting and blood stasis dispelling, tranquilizing the mind, relieving spasm to stop pain is monarch drug; Take Radix Bupleuri, Concha Margaritifera, Rhizoma Gastrodiae, Scorpio, Rhizoma Corydalis, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Ligustici, Herba Menthae, Flos Chrysanthemi is ministerial drug, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, endogenous wind stopping relieving convulsion, removing obstruction in the collateral to relieve pain; Take Radix Cyathulae, Semen Persicae, Flos Carthami, Cortex Moutan, Fructus Toosendan, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, Radix Clematidis, Semen Sinapis Albae is adjuvant drug, plays coordination, strengthens the treatment function of monarch drug and ministerial drug, and restrict the effect of the toxic and side effects of other drug; With Radix Scutellariae, Caulis Bambusae In Taenia, Retinervus Luffae Fructus, Fructus Cannabis and Radix Glycyrrhizae for making medicine, loosening bowel to relieve constipation, heat clearing and damp drying, activating collaterals to relieve pain, coordinating the actions of various ingredients in a prescription, and guide all medicines sick institute that goes directly.Processing technology of the present invention is easy, and toxic and side effects is little, and convenient drug administration, and medicament is easy to manufacture, with low cost, and the focus of going directly, and healing time is short, non-relapse after healing.

the present invention relates to Chinese medicine pharmacology and the property of medicine thereof as follows:

Radix Puerariae:

[meridian distribution of property and flavor] is sweet, pungent, cool; Return spleen, stomach warp.

[effect] relieving muscles diaphoresis, invigorating YANG QI to promote eruption, antipyretic promoting the production of body fluid.

[application] is for fever caused by exogenous pathogens headache, neck pain, measles without adequate eruption etc.

The Radix Paeoniae Alba:

[meridian distribution of property and flavor] acid, flat, be slightly cold; Return liver, spleen channel.

[effect] yin fluid astringing that nourishes blood, suppressing liver-YANG, relieving spasm to stop pain.

[application] breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.

Rhizoma Gastrodiae:

[meridian distribution of property and flavor] is sweet, flat; Return Liver Channel.

[effect] endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral.

The Radix Angelicae Dahuricae:

[nature and flavor] are pungent, temperature; Return lung, spleen, stomach warp.

[effect] expelling wind and cold, understand things pain-stopping, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving, dampness leukorrhagia stopping.

[application] for mastalgia, swell and ache, have a headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.The modern pharmacological research proof Radix Angelicae Dahuricae also has antiinflammatory, antipyretic-antalgic, active eliminating stagnation, can be used for controlling the effects such as mammary gland caking with other Chinese Medicine and Clavicular.

Radix Bupleuri:

[meridian distribution of property and flavor] cold nature, bitter in the mouth, pungent; Return Liver Channel, lung meridian, spleen channel.

[effect] expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.

[application] cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.

Fructus Toosendan (having another name called Fructus Toosendan)

[nature and flavor] are cold in nature, bitter in the mouth; Return Liver Channel.

[effect] is a kind of of qi-activating drug, has catharsis liver-heat, promoting the circulation of QI to relieve pain effect.

[application] has the function except damp and hot, clearing away liver-fire, pain relieving, parasite killing.

Rhizoma Corydalis:

[meridian distribution of property and flavor] acrid in the mouth, hardship, warm in nature; GUIXIN, spleen, liver, lung.　　

[effect] promoting blood circulation to remove blood stasis, promoting the circulation of QI pain relieving.

[application] for each qi depression to blood stasis of whole body pain, dysmenorrhea, amenorrhea, lump in the abdomen, postpartum stagnation, injury from falling down, hernia is had a pain.

Concha Margaritifera:

[meridian distribution of property and flavor] is salty, cold; Return liver, heart channel.

[effect] suppressing the hyperactive liver and subsiding YANG, the arresting convulsion of calming the nerves, liver heat removing and eyesight improving.

[application] cures mainly dizziness, tinnitus, and cardiopalmus, insomnia, demented, infantile convulsion, spits blood, epistaxis etc.

Ramulus Cinnamomi:

[meridian distribution of property and flavor] taste acrid, sweet, warm; GUIXIN, lung, urinary bladder channel.

[effect] diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI.

[application] for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Radix Clematidis:

[meridian distribution of property and flavor] acrid in the mouth, salty, temperature; Return urinary bladder channel.

[effect] wind-damp dispelling, the meridian dredging, expectorant Ting, the loose hypochondriac lump.

[application] cures mainly gout, insensitive impediment, chills and pain of the waist and kness, beriberi, tetanus.

Semen Sinapis Albae:

[meridian distribution of property and flavor] is warm in nature, acrid in the mouth; Return lung meridian.

[effect] warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.

[application] cures mainly cough with asthma abundant expectoration; Fullness in the chest and hypochondriac pain; Numb limbs and tense tendons; Arthralgia; Multiple abscess caused by damp-phlegm; Carbuncle of yin nature toxic swelling; Control acute mastitis, breast carcinoma, mammary gland pain, tuberculosis, phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation vomiting, aphasia due to apoplexy, limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury etc.

Retinervus Luffae Fructus:

[meridian distribution of property and flavor] sweet in the mouth, cool in nature; Return lung, liver, stomach warp.

[effect] dredge the meridian passage, heat-clearing and toxic substances removing, inducing diuresis to remove edema, hemostasis.

[application] cures mainly distending pain in the chest and hypochondrium, rheumatic arthralgia, and the contracture of muscle arteries and veins, woman's amenorrhea, galactostasis, phlegm-heat cough, pyretic toxicity carbuncle, anal fistula, edema, dysuria, has blood in stool, metrorrhagia.

Semen Persicae:

Sweet flat, the bitter in the mouth of [meridian distribution of property and flavor] property; Lung, liver, large intestine channel;

[effect] blood stasis removing and clots absorbing, moisturizes laxation.

[application] cures mainly amenorrhea, dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, traumatic injury, dryness of the intestine constipation.

Flos Carthami:

[meridian distribution of property and flavor] is warm in nature, acrid in the mouth, GUIXIN, Liver Channel.　

[effect] promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.

[application], for amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury, is suitable for various varicosis, peripheral neuritis etc.

Rhizoma Chuanxiong:

[meridian distribution of property and flavor] is pungent, temperature; Return liver, gallbladder, pericardium channel.

[effect] activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.

[application] control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Radix Cyathulae:

[meridian distribution of property and flavor] sweet, micro-hardship, flat; Return liver, kidney channel.

[effect] eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.

[application] for amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood.

Flos Chrysanthemi:

[meridian distribution of property and flavor] is bitter, pungent, is slightly cold; Return liver, heart channel.

[effect] has dispelling wind, heat clearing away, improving eyesight ,the effect of removing toxic substances.

The diseases such as [application] primary treatment headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Modern pharmacological research shows, Flos Chrysanthemi has treatment coronary heart disease, reduces blood pressure, prevents hyperlipidemia, antibacterial, antiviral, antiinflammatory, the anti-ageing multiple pharmacologically active of waiting for a long time.

Radix Scutellariae:

[meridian distribution of property and flavor] bitter in the mouth, cold; Return lung, gallbladder, spleen, large intestine, small intestine meridian.

[effect] heat clearing and damp drying, eliminating fire and detoxication, arresting bleeding and miscarriage prevention.

[application] for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, and dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Cortex Moutan:

[meridian distribution of property and flavor] is cold in nature, bitter in the mouth, pungent; GUIXIN, liver, kidney channel.

[effect] clearing away heat and cooling blood, blood circulation promoting competent silt.

[application] for maculae caused by violent heat pathogen, tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus.Rhizoma Et Radix Notopterygii:

[meridian distribution of property and flavor] acrid in the mouth, hardship, temperature; Return bladder, kidney channel.

[effect] exterior cold of faling apart, wind-damp dispelling, sharp joint.

[application] cures mainly cold, have a headache lossless, and anemofrigid-damp arthralgia, stiffness of the nape muscular contracture, joint ache, edema due to wind pathogen edema.

Scorpio:

[meridian distribution of property and flavor] acrid in the mouth is flat; Return Liver Channel.

[effect] spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.

[application] for infantile convulsion, tic spasm, and middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.

Caulis Bambusae In Taenia:

[meridian distribution of property and flavor] cold nature, sweet in the mouth; Attach to the lung and stomach meridians.

[effect] removing heat-phlegm, relieves restlessness and prevents vomiting.

[application] holds expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm for phlegm-heat cough, gallbladder fire.

Radix Salviae Miltiorrhizae:

[meridian distribution of property and flavor] cold nature, bitter in the mouth; GUIXIN, spleen channel.

[effect] has the function of calming the nerves, living blood stasis and tissue regeneration promoting blood.

[application] treatment headache, acute conjunctivitis, hot temperature is mad vexed; Control menoxenia, dysmenorrhea, rheumatic arthralgia, spits blood, mastitis, carbuncle.

Fructus Cannabis:

[meridian distribution of property and flavor] sweet in the mouth, property is flat, returns spleen, stomach, large intestine channel,

[effect] loosening bowel to relieve constipation, moisturize parasite killing.

[application] for blood deficiency and depleted fluid, dryness of the intestine constipation.

Rhizoma Ligustici:

[meridian distribution of property and flavor] is pungent, temperature; Return urinary bladder channel.　　

[effect] dispels the wind, cold expelling, dehumidifying, pain relieving.

[application] for anemofrigid cold, top, mountain peak pain, rheumatism podomere arthralgia pain.

Herba Asari:

[meridian distribution of property and flavor] acrid in the mouth, temperature, returns lung, kidney channel;

[effect] has expelling wind and cold, understand things pain-stopping, the effect of warming the lung to resolve fluid-retention.

[application] dispels the wind, cold expelling, and row water, has one's ideas straightened out; Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.

Herba Menthae:

[meridian distribution of property and flavor] is cool in nature, acrid in the mouth; Return lung meridian, Liver Channel.

The effect of [effect] irritation causes trachea to produce new secretion, and makes the mucus of stiff be easy to get rid of, therefore there is the effect of eliminating the phlegm, sterilizing.

[application] cures mainly influenza, headache, conjunctival congestion, fever of the body, throat, the dental bed disease such as swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.

Radix Glycyrrhizae:

[meridian distribution of property and flavor] is sweet, flat.GUIXIN, lung, spleen, stomach warp.

[effect] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

[application] for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

the specific embodiment:

The headache that this Chinese medicine preparation is treated mainly refers to the functional headaches such as tension headache and angioneurotic headache, risk factor mostly is psychentonia, suffers from cold and anger, cardinal symptom is head pain, constriction, the sense of heaviness of persistence, and some patient's private prosecutions are head " lock ring " sense.Most of patient's painful area is many at two temporo sides, rear pillow part and head or full head.The character of headache is dull pain, distending pain, constriction, feeling of numbness or the sense of band sample lock ring.

The headache degree that this Chinese medicine preparation is treated mostly is slightly to moderate, and only a few patient is unable to leave the bed because of headache, has a strong impact on daily life.Can there is persistence headache year in year out, the even sustainable 10-20 of the symptom of some patients were in most of patients.The factors such as excited, angry, insomnia, anxiety can cause that the pain increased.Tension headache and angioneurotic headache merge simultaneously outbreak patient also comparatively common clinically, we are also called mixed type headache.Its main manifestations is both sides temples throbbing pains, how with dizziness, irritated irritability, anxious, have palpitation, breathe hard, the symptom such as fear, tinnitus, insomnia and dreamful sleep, Wry Neck.Some patients were in neckpillow both sides or two temporo sides there is obvious pressure pain point.

This Chinese medicine preparation treatment functional headache was undertaken by the course for the treatment of, and general case one month is a course for the treatment of, can be at outpatient service medication treatment.The course of disease 10-20 chronic case of remaining year, needs to carry out Comprehensive Treatment in hospital, generally needs 2-3 the course for the treatment of.Be in hospital Comprehensive Treatment except adopting this Chinese medicine preparation, also need to coordinate psychological counseling, so just can obtain better effect.

embodiment 1, formula:radix Puerariae 15g, Radix Paeoniae Alba 30g, Rhizoma Gastrodiae 10g, Radix Angelicae Dahuricae 10g, Radix Bupleuri 15g, Fructus Toosendan 10g, Rhizoma Corydalis 15g, Concha Margaritifera 15g, Ramulus Cinnamomi 6g, Radix Clematidis 10g, Semen Sinapis Albae 10g, Retinervus Luffae Fructus 10g, Semen Persicae 10g, Flos Carthami 5g, Rhizoma Chuanxiong 30g, Radix Cyathulae 15g, Flos Chrysanthemi 10g, Radix Scutellariae 10g, Cortex Moutan 10g, Rhizoma Et Radix Notopterygii 6g, Scorpio 6g, Caulis Bambusae In Taenia 10g, Radix Salviae Miltiorrhizae 30g, Fructus Cannabis 15g, this 10g of Gao, Herba Asari 3g, Herba Menthae 6g, Radix Glycyrrhizae 6g;

The dosage form of Chinese medicine preparation of the present invention is capsule, and its preparation method is as follows:

The 50-90% soak with ethanol 1-3 hour that adds 6-12 doubly to measure above-mentioned raw materials medicine by formula proportion, reflux, extract, is extracted 1-3 time, and each 1-3 hour, gets supernatant, is evaporated to extractum shape, as component 1; Medicinal residues are soaked to 0.5-1.5 hour, decoct 2 times, each 1-2 hour, merge decoction liquor, filter, concentrated, 80-160 order filters, the 6000-10000 rev/min of supernatant after centrifugal, is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, and ultrafiltrate concentrating under reduced pressure relative density is 1.30(60 ℃) extractum; Above-mentioned two kinds of extractum concentrate dryings are become to dry cream, co-grinding, fill capsule.

embodiment 2, formula:radix Puerariae 20g, Radix Paeoniae Alba 32g, Rhizoma Gastrodiae 12g, Radix Angelicae Dahuricae 12g, Radix Bupleuri 16g, Fructus Toosendan 12g, Rhizoma Corydalis 16g, Concha Margaritifera 18g, Ramulus Cinnamomi 7g, Radix Clematidis 11g, Semen Sinapis Albae 11g, Retinervus Luffae Fructus 11g, Semen Persicae 11g, Flos Carthami 6g, Rhizoma Chuanxiong 32g, Radix Cyathulae 16g, Flos Chrysanthemi 11g, Radix Scutellariae 11g, Cortex Moutan 11g, Rhizoma Et Radix Notopterygii 7g, Scorpio 7g, Caulis Bambusae In Taenia 11g, Radix Salviae Miltiorrhizae 32g, Fructus Cannabis 16g, this 11g of Gao, Herba Asari 4g, Herba Menthae 7g, Radix Glycyrrhizae 7g;

The dosage form of Chinese medicine preparation of the present invention is tablet, and its preparation method is as follows:

By formula proportion, Flos Carthami, Flos Chrysanthemi and Herba Menthae are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1-2 hour, extracts active ingredient, and 2 extracting solution are merged standing; Surplus stock is put into 10 times of water gagings, heating and refluxing extraction 3 times, each 30 minutes-1 hour, merges standing by 3 extracting solution again; Finally by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.08 (20 ℃); The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains crude drug; Add starch or dextrin tabletting.

embodiment 3, formula:radix Puerariae 22g, Radix Paeoniae Alba 35g, Rhizoma Gastrodiae 13g, Radix Angelicae Dahuricae 13g, Radix Bupleuri 17g, Fructus Toosendan 13g, Rhizoma Corydalis 15g, Concha Margaritifera 20g, Ramulus Cinnamomi 8g, Radix Clematidis 12g, Semen Sinapis Albae 12g, Retinervus Luffae Fructus 12g, Semen Persicae 12g, Flos Carthami 10g, Rhizoma Chuanxiong 38g, Radix Cyathulae 18g, Flos Chrysanthemi 13g, Radix Scutellariae 13g, Cortex Moutan 13g, Rhizoma Et Radix Notopterygii 8g, Scorpio 8g, Caulis Bambusae In Taenia 13g, Radix Salviae Miltiorrhizae 35g, Fructus Cannabis 18g, this 13g of Gao, Herba Asari 4.5g, Herba Menthae 8g, Radix Glycyrrhizae 8g;

The dosage form of Chinese medicine preparation of the present invention is honey refining pill, and its preparation method is as follows:

By formula proportion, medical material is soaked 30 minutes to 1 hour, heated and boiled 30 minutes, filters filtrate for later use; Filtering residue adds water, and heating, boils 30 minutes for the second time, refilters filtrate for later use; Filtering residue adds water again, and heated and boiled is 30 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 ℃, is cooled to be Powderedly twisted into slice together with being mixed in right amount with Mel after oven dry; Every 5g of take refines pill as a ball wax seal is packaged into honey.

embodiment 4, formula:radix Paeoniae Alba 40g, Rhizoma Gastrodiae 14g, Radix Angelicae Dahuricae 14g, Radix Bupleuri 18g, Fructus Toosendan 14g, Rhizoma Corydalis 18g, Concha Margaritifera 25g, Ramulus Cinnamomi 9g, Radix Clematidis 14g, Semen Sinapis Albae 14g, Retinervus Luffae Fructus 14g, Semen Persicae 14g, Flos Carthami 12g, Rhizoma Chuanxiong 42g, Radix Cyathulae 19g, Flos Chrysanthemi 14g, Radix Scutellariae 14g, Cortex Moutan 14g, Rhizoma Et Radix Notopterygii 9g, Scorpio 9g, Caulis Bambusae In Taenia 14g, Radix Salviae Miltiorrhizae 42g, Fructus Cannabis 19g, this 14g of Gao, Herba Asari 5g, Herba Menthae 9g, Radix Glycyrrhizae 9g;

Preparation method is identical with embodiment 1.

embodiment 5, formula:radix Puerariae 30g, Radix Paeoniae Alba 45g, Rhizoma Gastrodiae 15g, Radix Angelicae Dahuricae 15g, Radix Bupleuri 20g, Fructus Toosendan 15g, Rhizoma Corydalis 20g, Concha Margaritifera 30g, Ramulus Cinnamomi 10g, Radix Clematidis 15g, Semen Sinapis Albae 15g, Retinervus Luffae Fructus 15g, Semen Persicae 15g, Flos Carthami 15g, Rhizoma Chuanxiong 45g, Radix Cyathulae 20g, Flos Chrysanthemi 15g, Radix Scutellariae 15g, Cortex Moutan 15g, Rhizoma Et Radix Notopterygii 10g, Scorpio 10g, Caulis Bambusae In Taenia 15g, Radix Salviae Miltiorrhizae 45g, Fructus Cannabis 20g, this 15g of Gao, Herba Asari 6g, Herba Menthae 10g, Radix Glycyrrhizae 10g;

Preparation method is identical with embodiment 1.

pharmacology pharmacodynamic experiment:

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: the Traditional Chinese medicine preparation capsule agent of the present invention of mice oral administration gavage, under 485.7g crude drug/kg dosage, after administration, mice occurs that light activity reduces, about 2 hours, recover normal, after administration, Continuous Observation is 7 days, without animal dead, its overall health of patients, to take the photograph water, diet, urine and body weight gain all normal, and experimental result shows: the maximum dosage-feeding of mice oral administration gavage Traditional Chinese medicine preparation capsule agent of the present invention is 485.7g crude drug/kg/d (LD 50 > 485.7g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.5g crude drug/kg/d; Press weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is clinical patient 971.4 times.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select rat, give the Chinese medicine preparation pill of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, after last administration, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half), and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, and after administration, the index checkings such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, BUN, Crea, Glu, TP, ALB, CHOL), urine biochemistry, organ coefficient, histopathology are carried out in 90 days and drug withdrawal for 2 weeks.Result of the test shows: preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Three dosage groups and matched group hematological examination, blood biochemical are learned, urine biochemical analysis is all in normal range, between group without significant difference; Each is organized main organs histopathological examination and shows no obvious abnormalities.These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicine preparation of the present invention, in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days, rat is had no significant effect, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.

1 clinical data

The all cases of 1.1 physical data are I Out-patient Department and inpatient, the patient who is the above headache such as nervous headache, vascular headache, migraine, muscular tone headache, menstruation headache, headache due to brain trauma, epilepsy headache, hypertensive headache disease gets rid of the patient that the diseases such as liver, gallbladder, the heart, lung need be accepted Drug therapy for a long time simultaneously.

Treatment group 102 examples, male 66 examples, female's 36 examples; 19～68 years old age;

Matched group 40 examples, male 27 examples, female's 13 examples; 18～67 years old age;

2 groups of ages, sexes, there are no significant difference, have comparability.

1.2 Therapeutic Method

Matched group adopts merely western medicine therapy: ibuprofen bufferin plus, each a slice of being grown up, if symptom do not alleviate, interval 4-6 hour can repeated drug taking once; Loose profit pain, each 1-2 sheet, treat every day for 3 times.

Treatment group gives treatment by Chinese herbs of the present invention,

Each 2 of capsule, every day 3 times, warm water takes, and serve on January;

Or each 4 of tablet, every day 3 times, warm water takes, and serve on January;

Or each 9 grams of pill, every day 3 times, warm water takes, and serve on January.

1.3 observational technique

1. short term effect: check after taking medicine 1 month, 2 months; The cure rate of symptom, improvement rate.

2. late result: check rehabilitation is followed up a case by regular visits to, as occur symptom person repeatedly, row checks again, records the state of an illness.

2 observation of curative effect

2.1 efficacy assessment standard evaluation criterias are with reference to Ministry of Public Health clinical drug research guideline.

1. symptom: mainly observe head pain, minutes 0,1,2,3 grades.Without pain symptom, be 0 grade, have pain symptom, not affecting work or not needing pill taker is 1 grade; Have pain symptom, some effects work or normal pill taker are 2 grades; There is pain symptom, an essential complete rest, the medicine does no good to, and person is 3 grades.It is effective that the rear symptom for the treatment of is obviously improved >2 level; Symptom is obviously improved >1 level for effective; Symptom is without improving or increasing the weight of as invalid.

2.2 2 groups of check result comparisons

Treatment group is cured 94 examples, 6 examples that take a turn for the better, invalid 2 examples, cure rate >=92%, effective percentage >=98%.

Matched group is cured 35 examples, 2 examples that take a turn for the better, invalid 3 examples, cure rate >=87%, effective percentage >=92%.Learn and process by statistics, 2 groups of there was no significant differences (P>0.05).

2.3 2 groups of Long term follow up results

Treatment group obtains visits 90 examples, recurrence 6 examples in 1 a, and relapse rate < 7%; Recurrence 13 examples in 3 a, relapse rate < 15%.

Matched group obtains visits 32 examples, recurrence 15 examples in 1 a, and recurrence 19 examples in relapse rate > 46%, 3 a, relapse rate is greater than 59%.

2 groups relatively have significant difference (P<0.01).

model case:

Case 1, Zhao's treasured, female.Right side migraine more than 10 years, increases the weight of half a year.Patient goes out to suffer from cold after having a bath before 10 years and causes head pain, after hospital treatment, takes a turn for the better.After this often feel head pain, take right side pain as main, symptom increases the weight of gradually.Over more than ten years, toss about in bed Ge Jia hospital, the medical treatment in clinic among the people, is diagnosed as the pathological changes such as " migraine ", " angioneurotic headache ", " temporal arteritis ", once accepts Chinese and western drugs and acupuncture and moxibustion therapy all without obviously imitating.Headache increases the weight of gradually closely over the past half year, take " 2 of tablet for alleviating pain, 2 of NAOQING sheets " day twice, and headache can alleviate.But take with the passing of time, often there is discomfort in gastral cavilty portion.Patient suffering can't bear.Come me outpatient service to seek medical advice, take after 1 month, state of an illness recovery from illness.

Case 2, Liu Jixi, female.Patient has a headache more than 6 years, outbreak repeatedly, and during outbreak, headache unbearably, often, with feeling sick, vomitting, maintains by taking analgesic drug product.Effective while just starting, effect weakened gradually afterwards.Once many large hospitals in provincial capital of going to a doctor, the inspections such as row eye, head, cervical vertebra, are showed no abnormal.Often there are fatigue, cold or emotional distress to bring out.Western medicine diagnose is " angioneurotic headache ".Since nearly February, because of work strain, brain overwork and suffer from cold and bring out, takes tablet for alleviating pain without any effect.2 weeks rear headache symptoms of capsule that patient takes in the embodiment of the present invention 1 disappear substantially, advise patient to take a good rest, suitably movable, mind at rest as far as possible, and note warming.Follow the tracks of and have no repeatedly for 3 months.

Case 3, Zhao Jianguo, man.Patient occurs that without obvious inducement head tightens sample pain at the beginning of 2008, and when bad, the psychentonia of sleeping, Changes in weather, pain increases the weight of, and originally pain still can be stood, and the state of an illness increases the weight of gradually, and cause patient insomnia because of pain night, and appetite is poor.In the row acupuncture and moxibustion therapy of our province Duo Jia hospital, symptom is without being clearly better.Once arrived Beijing front three hospital admission, diagnosis " tension headache ", gives Chinese and western drugs Comprehensive Treatment, and symptom is not improved.Rear patient Lai Wo section treatment upon somebody's introduction, is diagnosed as " tension-type headache ", takes the present invention's honey refining pill after 15 days, and headache is alleviated substantially, adheres to the February of taking medicine, and headache symptom disappears completely, follows up a case by regular visits to without recurrence.

Case 4, Ding Weihong, female.Repeated relapsing headache 4 years.Before 4 years, after anger, there is volume top pulsation dull pain, time and left side, time and right side.Si dol urg is with feeling sick, vomitting.After taking diazepam rest, pain can disappear.Row cranium brain CT shows no obvious abnormalities.Take Chinese medicinal tablet of the present invention after 7 days, headache is alleviated substantially, changes pill and deals with problems arising from an accident, and takes medicine January again, and state of an illness recovery from illness, follows up a case by regular visits to without recurrence.

Case 5, Liu Zhenfan.Man, has a headache more than 5 years, or forehead or back or top, mountain peak, and painful area is fixing, is pulsation jumping pain, with nausea and vomiting, doublely see dizzy, insomnia, agitation.Through inspections such as CT, electroencephalogram, rheoencephalograms, all there is not obvious change.Take Chinese medicine capsules of the present invention more than 20 days, sick announcement fully recovered.

Case 6, Li Chenming, man.Have a headache 3 years.There is headache in the brain overwork of reading during senior middle school, take left side pain as main, and characteristic of pain is dull pain, and before sleeping night, the most very, irascible temperament, when anything crops up easy on the trigger usually for pain,

Companion's alopecia, insomnia and dreamful sleep.Once row acupuncture and moxibustion therapy, symptom takes a turn for the better gradually.Be admitted to after university, because reviewing examination, study assiduously, headache recurrence.Row acupuncture and moxibustion therapy again, poor effect.Here gave Chinese medicine capsules treatment 2 courses for the treatment of afterwards, and symptom is subdued gradually, follows up a case by regular visits to without recurrence.

Case 7, Zhang Yanhong, female.Forehead dull pain 2 years endlessly.Take Western medicine " ibuprofen " and slightly must alleviate, multiple outbreak again, spreads gradually to whole head in a moment, and pain becomes migration.Since 1 month, forehead dull pain is increasingly sharpened, every because fatigue, wind-engaging, emotion irritability etc. bring out, with neck sweating, and slight aversion to wind, insomnia and dreamful sleep, deficiency of QI with disinclination to talk.Row cranium brain CT and TCD,transcranial Doppler, show no obvious abnormalities.Western medicine diagnose is " nervous headache ".Take Chinese medicine capsules of the present invention 3 weeks, state of an illness recovery from illness.

Case 8, Ma Shenghua, female.Before 9 years, without obvious inducement, occurred headache, from right side occipitalia, begin, involve top, right side, temples, forehead, be the sample of beating, degree is inviolent, and continuing more than 20 minutes can spontaneous remission, and 2-3 is interrupted outbreak afterwards, and outbreak irregularly.Without nauseating, vomiting, photophobia, phonophobia, disturbance of consciousness, disorder of limb ' s activity etc.Once carried out X-ray of cervical spine and find hyperosteogeny of cervical vertebra, symptomatic treatment effect is not good enough.Before 1 year, headache aggravates to some extent, and painful area does not change, pulsation, and each outbreak is with nauseating, vomiting, photophobia.Take Chinese medicine capsules of the present invention February, headache transference cure, state of an illness recovery from illness.

Case 9, Mao Xiaoli, female.Have a headache 3 years, pain is persistence distending pain, and paroxysmal increases the weight of, and headache be take temples as main, and Chang Congyi side is transferred to opposite side, and without very dizzy sense, idol has nauseating, without vomiting.Menstrual phase and front and back above-mentioned symptom thereof are obvious, without blurred vision, ghost image, without cervical pain.Do not do special handling always.Before January, pain increases the weight of, and gives after treatments such as " lomerizine, Qiyeshen an sheets " headache and has no and be clearly better.Give Chinese medicine capsules of the present invention and treat after February, state of an illness recovery from illness, follows up a case by regular visits to without recurrence.

Claims (6)

1. a Chinese medicine preparation for the treatment of headache, the ratio of weight and number that it is characterized in that various crude drug in this Chinese medicine preparation is: Radix Puerariae 15-30 part, Radix Paeoniae Alba 30-45 part, Rhizoma Gastrodiae 10-15 part, Radix Angelicae Dahuricae 10-15 part, Radix Bupleuri 15-20 part, Fructus Toosendan 10-15 part, Rhizoma Corydalis 15-20 part, Concha Margaritifera 15-30 part, Ramulus Cinnamomi 6--10 part, Radix Clematidis 10-15 part, Semen Sinapis Albae 10-15 part, Retinervus Luffae Fructus 10-15 part, Semen Persicae 10-15 part, Flos Carthami 5-15 part, Rhizoma Chuanxiong 30-45 part, Radix Cyathulae 15-20 part, Flos Chrysanthemi 10-15 part, Radix Scutellariae 10-15 part, Cortex Moutan 10-15 part, Rhizoma Et Radix Notopterygii 6-10 part, Scorpio 6-10 part, Caulis Bambusae In Taenia 10-15 part, Radix Salviae Miltiorrhizae 30-45 part, Fructus Cannabis 15-20 part, this 10-15 of Gao part, Herba Asari 3-6 part, Herba Menthae 6-10 part, Radix Glycyrrhizae 6-10 part.

2. Chinese medicine preparation according to claim 1, it is characterized in that: the ratio of weight and number of various crude drug is: Radix Puerariae 20-25 part, Radix Paeoniae Alba 32-40 part, Rhizoma Gastrodiae 12-14 part, Radix Angelicae Dahuricae 12-14 part, Radix Bupleuri 16-18 part, Fructus Toosendan 12-14 part, Rhizoma Corydalis 16-18 part, Concha Margaritifera 18-25 part, Ramulus Cinnamomi 7-9 part, Radix Clematidis 11-14 part, Semen Sinapis Albae 11-14 part, Retinervus Luffae Fructus 11-14 part, Semen Persicae 11-14 part, Flos Carthami 6-12 part, Rhizoma Chuanxiong 32-42 part, Radix Cyathulae 16-19 part, Flos Chrysanthemi 11-14 part, Radix Scutellariae 11-14 part, Cortex Moutan 11-14 part, Rhizoma Et Radix Notopterygii 7-9 part, Scorpio 7-9 part, Caulis Bambusae In Taenia 11-14 part, Radix Salviae Miltiorrhizae 32-42 part, Fructus Cannabis 16-19 part, this 11-14 of Gao part, Herba Asari 4-5 part, Herba Menthae 7-9 part, Radix Glycyrrhizae 7-9 part.

3. Chinese medicine preparation according to claim 1, it is characterized in that: the ratio of weight and number of various crude drug is: 22 parts of Radix Puerariaes, 35 parts of the Radix Paeoniae Albas, 13 parts, Rhizoma Gastrodiae, 13 parts of the Radixs Angelicae Dahuricae, 17 parts of Radix Bupleuri, 13 parts of Fructus Toosendans, 15 parts of Rhizoma Corydalis, 20 parts of Concha Margaritiferas, 8 parts of Ramulus Cinnamomi, 12 parts of Radix Clematidis, 12 parts of Semen Sinapis Albaes, 12 parts of Retinervus Luffae Fructuss, 12 parts, Semen Persicae, 10 parts, Flos Carthami, 38 parts of Rhizoma Chuanxiongs, 18 parts of Radix Cyathulaes, 13 parts of Flos Chrysanthemis, 13 parts of Radix Scutellariaes, 13 parts of Cortex Moutans, 8 parts of Rhizoma Et Radix Notopterygiis, 8 parts of Scorpios, 13 parts of Caulis Bambusae In Taenia, 35 parts of Radix Salviae Miltiorrhizaes, 18 parts of Fructus Cannabiss, these 13 parts of Gao, 4.5 parts of Herba Asaris, 8 parts of Herba Menthaes, 8 parts of Radix Glycyrrhizae.

4. the Chinese medicine preparation described in claims 1-3 any one, body characteristics is: the pharmaceutical dosage form of Chinese medicine preparation comprises capsule, tablet, granule, honey pill agent, powder, sublimed preparation, injection, suppository, plaster, syrup, powder, pin powder or patch.

5. Chinese medicine preparation claimed in claim 4, is characterized in that: the preparation method that the dosage form of this Chinese medicine preparation is capsule comprises:

A, getting crude drug and add ethanol extraction 1 time, become extractum shape, is component 1;

B, medicinal residues extracting in water 2 times, thickening filtration is extractum shape, is component 2;

C, above-mentioned two kinds of extractum concentrate dryings are become to dry cream, co-grinding, loads capsule;

In described a, can get the 60-90% soak with ethanol 1-2 hour that crude drug adds 5-8 doubly to measure, heating extraction 1-2 hour, removes supernatant, and mass is concentrated into extractum shape, becomes component 1;

In described b, can soak 0.5-1.5 hour by medicinal residues, extract twice, each 1-2 hour, merge extractive liquid,, filters, concentrated, 80-160 order filters, the 6000-10000 rev/min of supernatant after centrifugal, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000,1.35 extractum when ultrafiltrate concentrating under reduced pressure relative density is 60 ℃, heating and refluxing extraction 2 times, each 30 minutes～45 minutes, extract active ingredient, 2 extracting solution are merged and are settled into extractum shape, as component 2.

6. Chinese medicine preparation claimed in claim 4, is characterized in that: the preparation method that described Chinese medicine preparation dosage form is tablet comprises:

A, Flos Carthami, Flos Chrysanthemi and Herba Menthae are put into ethanol heating and refluxing extraction;

B, get the surplus stock in above-mentioned side again, add water heating and refluxing extraction;

C, above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol concentrated sucking filtration absorption, obtain crude drug; Add dextrin or starch tabletting;

In described a, Flos Carthami, Flos Chrysanthemi and Herba Menthae can be put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, extract active ingredient, 2 extracting solution are merged standing;

In described b, surplus stock is put into 10 times of water gagings, heating and refluxing extraction 3 times, each 30 minutes～1 hour, merges standing by 3 extracting solution;

In described c, can be by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.08 (20 ℃); The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains crude drug; Add starch or dextrin tabletting.