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CN103893376B - A kind of Chinese medicine composition for treating skin eczema bleb and preparation method thereof - Google Patents

A kind of Chinese medicine composition for treating skin eczema bleb and preparation method thereof Download PDF

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CN103893376B
CN103893376B CN201410153679.8A CN201410153679A CN103893376B CN 103893376 B CN103893376 B CN 103893376B CN 201410153679 A CN201410153679 A CN 201410153679A CN 103893376 B CN103893376 B CN 103893376B
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李国宣
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Abstract

本发明公开了一种治疗皮肤湿疹疱疹的中药组合物,所述组合物的原料药组成为:大叶青根20‑40重量份、大叶桉40‑60重量份、瓦松20‑40重量份、金银花10‑30重量份、野菊花10‑30重量份、白英40‑60重量份、雄黄15‑35重量份、薄荷20‑40重量份、生地榆20‑40重量份、麻油120‑140重量份、鲜杠板归40‑60重量份、虎杖根20‑40重量份、明矾25‑45重量份、蓖麻子5‑25重量份和羊蹄根20‑40重量份为原料药制成的中药组合物在治疗皮肤湿疹疱疹等方面具有显著的治疗效果,见效快,费用低,使用方便。The invention discloses a traditional Chinese medicine composition for treating skin eczema and herpes. The raw materials of the composition are composed of: 20-40 parts by weight of Echinacea Echinacea, 40-60 parts by weight of Eucalyptus eucalyptus, and 20-40 parts by weight of Vasong , 10-30 parts by weight of honeysuckle, 10-30 parts by weight of wild chrysanthemum, 40-60 parts by weight of Baiying, 15-35 parts by weight of realgar, 20-40 parts by weight of peppermint, 20-40 parts by weight of raw Burnet, 120-140 parts by weight of sesame oil Parts by weight, 40-60 parts by weight of fresh barley, 20-40 parts by weight of Polygonum cuspidatum root, 25-45 parts by weight of alum, 5-25 parts by weight of castor bean and 20-40 parts by weight of Radix Radix Radix are the traditional Chinese medicine made from raw materials The composition has remarkable curative effect in treating skin eczema herpes and the like, has quick effect, low cost and is convenient to use.

Description

一种治疗皮肤湿疹疱疹的中药组合物及其制备方法A traditional Chinese medicine composition for treating skin eczema and herpes and its preparation method

技术领域technical field

本发明属于中药制剂领域,具体涉及一种治疗皮肤湿疹疱疹的中药组合物及其制备方法。The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition for treating skin eczema herpes and a preparation method thereof.

背景技术Background technique

皮肤湿疹是由多种内外因素引起的瘙痒剧烈的一种皮肤炎症反应。分急性、亚急性、慢性三期。急性期具渗出倾向,慢性期则浸润、肥厚。有些病人直接表现为慢性湿疹。皮损具有多形性、对称性、瘙痒和易反复发作等特点。湿疹病因复杂,常为内外因相互作用结果。内因如慢性消化系统疾病、精神紧张、失眠、过度疲劳、情绪变化、内分泌失调、感染、新陈代谢障碍等,外因如生活环境、气候变化、食物等均可影响湿疹的发生。外界刺激如日光、寒冷、干燥、炎热、热水烫洗以及各种动物皮毛、植物、化妆品、肥皂、人造纤维等均可诱发。是复杂的内外因子引起的一种迟发型变态反应。Skin eczema is a severe itching skin inflammatory reaction caused by various internal and external factors. Divided into acute, subacute and chronic stages. In the acute phase, it tends to exudate, while in the chronic phase, it is infiltrating and hypertrophic. Some patients directly show as chronic eczema. The skin lesions are characterized by pleomorphism, symmetry, itching, and recurrent attacks. The etiology of eczema is complicated, and it is often the result of the interaction between internal and external factors. Internal factors such as chronic digestive system diseases, mental stress, insomnia, excessive fatigue, emotional changes, endocrine disorders, infections, metabolic disorders, etc., and external factors such as living environment, climate change, food, etc. can all affect the occurrence of eczema. External stimuli such as sunlight, cold, dryness, heat, hot water scalding, and various animal fur, plants, cosmetics, soap, and artificial fibers can all be induced. It is a delayed allergic reaction caused by complex internal and external factors.

急性湿疹,皮损初为多数密集的粟粒大小的丘疹、丘疱疹或小水疱,基底潮红,逐渐融合成片,由于搔抓,丘疹、丘疱疹或水疱顶端抓破后呈明显的点状渗出及小糜烂面,边缘不清。如继发感染,炎症更明显,可形成脓疱、脓痂、毛囊炎、疖等。自觉剧烈瘙痒。好发于头面、耳后、四肢远端、阴囊、肛周等,多对称发布。湿疹病因复杂,治疗好转后仍易反复发作,难根治。因临床形态和部位各有特点,故用药因人而异。内用疗法,选用抗组胺药止痒,必要时两种配合或交替使用。泛发性湿疹可口服或注射糖皮质激素,但不宜长期使用。外用疗法,根据皮损情况选用适当剂型和药物。急性湿疹局部生理盐水、3%硼酸或1:2000~1:10000高锰酸钾溶液冲洗、湿敷,炉甘石洗剂收敛、保护。亚急性、慢性湿疹应用合适的糖皮质激素霜剂、焦油类制剂或免疫调节剂,如他克莫司软膏、匹美莫司软膏。继发感染者加抗生素制剂,亚急性湿疹,急性湿疹炎症减轻后,皮损以小丘疹、结痂和鳞屑为主,仅见少量丘疱疹及糜烂。仍有剧烈瘙痒。慢性湿疹常因急性、亚急性湿疹反复发作不愈而转为慢性湿疹;也可开始即为慢性湿疹,表现为患处皮肤增厚、浸润,棕红色或色素沉着,表面粗糙,覆鳞屑,或因抓破而结痂。自觉瘙痒剧烈。常见于小腿、手、足、肘窝、腘窝、外阴、肛门等处。病程不定,易复发,经久不愈。Acute eczema, the skin lesions are mostly dense miliary-sized papules, papules, or vesicles at the beginning, the base is flushed, and gradually merge into sheets, due to scratching, the tops of papules, papules, or blisters are scratched and then show obvious punctate exudation And small erosion surface, the edge is not clear. Such as secondary infection, the inflammation is more obvious, and pustules, pustules, folliculitis, boils, etc. can be formed. Conscious severe itching. It tends to occur on the head and face, behind the ears, distal extremities, scrotum, perianal area, etc., and is mostly distributed symmetrically. The etiology of eczema is complicated, and it is still easy to relapse after treatment and takes a turn for the better, so it is difficult to cure it. Due to the characteristics of clinical forms and parts, the medication varies from person to person. For internal therapy, antihistamines are used to relieve itching, and the two are used together or alternately when necessary. Generalized eczema can be taken orally or injected with corticosteroids, but it should not be used for a long time. For topical therapy, select appropriate dosage forms and drugs according to the skin lesions. For acute eczema, local physiological saline, 3% boric acid or 1:2000~1:10000 potassium permanganate solution rinse, wet compress, calamine lotion converges and protects. Subacute and chronic eczema should be treated with suitable glucocorticoid cream, tar preparations or immunomodulators, such as tacrolimus ointment and pimecrolimus ointment. Subacute eczema, subacute eczema, after the inflammation of acute eczema is relieved, the skin lesions are mainly small papules, incrustations and scales, with only a small amount of papules and erosions. Severe itching is still present. Chronic eczema often turns into chronic eczema due to repeated attacks of acute and subacute eczema; it can also be chronic eczema at the beginning, manifested as thickening, infiltration, brownish red or pigmentation of the affected area, rough surface, covered with scales, or due to Scratch and scab. Conscious severe itching. It is common in the calf, hands, feet, elbow fossa, popliteal fossa, vulva, anus, etc. The course of the disease is indefinite, easy to recur, and persists for a long time.

疱疹,中医称为热疮,是一种由疱疹病毒所致的病毒性皮肤病,分为生殖器疱疹、单纯疱疹、汗疱疹、带状疱疹。疱疹的病因如下,(1)棘层松解,由于表皮细胞间桥(桥粒及张力细丝等)的变性,细胞间失去了紧密的联系而成松解状态,因此形成表皮内的裂隙、水疮或大抱。导致棘层松解的原因有自身免疫因素,如天疱疹。遗传因素引起的棘层松解见于慢性家族性良性天癌疮、毛囊角化病;(2)基底细胞液化及基底膜病变,基底细胞液化是指表皮基底细胞发生空泡化或破碎,重者基底细胞层消失,棘细胞直接与真皮接触,免疫、遗传及药物过敏常是导致基底细胞液化的原因,见于遗传性大癌性表皮松解症、系统性红斑狼疮、皮肌炎、多形性红斑、药疹、大疮性扁平苔薛。基底膜病变是指在基底膜有自身抗体沉积或先天性病理缺陷,原因为自身免疫及遗传,由于基底膜病变引起的水痢疾病有大癌性类天疱疹、妊娠疱疹、原痕性类天疱疹、疱疹样皮炎、线状k人大抱病、获得性大癌性表皮松解症、先天性大病性表皮松解症、色素失禁症;(3)气球变性及网状变性,由于细胞内水肿,表皮细胞体积增大,形成气球状,细胞膨胀破裂、邻近残留的胞膜联成多数网状中隔,最后形成多房性水疮,多见于病毒感染性皮肤病;(4)海绵水肿,由于细胞间液体增加使细胞间隙增宽而形成水疮,见于湿疹,接触性皮炎、汗疱疹等;(5)血管炎,多属免疫复合物型变态反应所致,由于组织发生炎症坏死而形成水疮如变应性血管炎、白塞病、急性发热性嗜中性皮病等;(6)表皮颗粒状变性,又称表皮松解性角化过度,见于鱼鳞病;(7)表皮坏死剥脱,由于药物及金黄色葡萄球菌感染使表皮坏死松解,表皮剥脱,见于大癌性表皮松解性药疹及金黄色葡萄球菌性烫伤样综合征。Herpes, known as heat sore in traditional Chinese medicine, is a viral skin disease caused by herpes virus. It is divided into genital herpes, herpes simplex, sweat herpes, and herpes zoster. The etiology of herpes is as follows: (1) Acantholysis, due to the degeneration of epidermal intercellular bridges (desmosomes and tension filaments, etc.), the cells lose their close connection and become loose, thus forming intraepidermal fissures, water Sores or big hugs. Causes of acantholysis include autoimmune factors such as pemphigus. Acantholysis caused by genetic factors is seen in chronic familial benign acne and keratosis pilaris; (2) basal cell liquefaction and basement membrane lesions, basal cell liquefaction refers to vacuolation or fragmentation of epidermal basal cells, and severe cases The basal cell layer disappears, and the acanthine cells are in direct contact with the dermis. Immunity, genetics, and drug allergies are often the cause of basal cell liquefaction, which is seen in hereditary macrocarcinoma epidermolysis, systemic lupus erythematosus, dermatomyositis, and pleomorphism Erythema, drug eruption, large sore flat moss Xue. Basement membrane lesions refer to the deposition of autoantibodies or congenital pathological defects in the basement membrane. The reasons are autoimmunity and genetics. Diarrhea diseases caused by basement membrane lesions include large carcinomatous pemphigoid, herpes gestationis, and primordial pemphigoid. Herpes, dermatitis herpetiformis, linear K-human leprosy, acquired epidermolysis carcinosa, congenital epidermolysis lesion, pigment incontinence; (3) Balloon degeneration and reticular degeneration, due to intracellular edema, The volume of epidermal cells increases, forming a balloon shape, the cells swell and rupture, and the adjacent residual cell membranes are connected to form a plurality of reticular septa, and finally multilocular edema is formed, which is more common in viral infectious skin diseases; (4) spongy edema, due to The increase of intercellular fluid widens the intercellular space to form water sores, which are seen in eczema, contact dermatitis, sweat herpes, etc.; (5) vasculitis, mostly caused by immune complex type allergies, forms water sores due to inflammation and necrosis of tissues. Sores such as allergic vasculitis, Behcet's disease, acute febrile neutrophilic dermatosis, etc.; (6) granular degeneration of the epidermis, also known as epidermolytic hyperkeratosis, seen in ichthyosis; (7) epidermal necrosis and exfoliation , due to drugs and Staphylococcus aureus infection, epidermal necrolysis and exfoliation are seen in large cancer epidermolysis drug eruption and Staphylococcus aureus scald-like syndrome.

发明内容Contents of the invention

为此,本发明的目的在于提供一种治疗皮肤湿疹疱疹的中药组合物及其制备方法。For this reason, the object of the present invention is to provide a kind of Chinese medicine composition for the treatment of skin eczema herpes and preparation method thereof.

为解决上述技术问题,本发明提供了一种治疗皮肤湿疹疱疹的中药组合物,所述组合物的原料药组成为:大叶青根20-40重量份、大叶桉40-60重量份、瓦松20-40重量份、金银花10-30重量份、野菊花10-30重量份、白英40-60重量份、雄黄15-35重量份、薄荷20-40重量份、生地榆20-40重量份、麻油120-140重量份、鲜杠板归40-60重量份、虎杖根20-40重量份、明矾25-45重量份、蓖麻子5-25重量份和羊蹄根20-40重量份。In order to solve the above-mentioned technical problems, the present invention provides a traditional Chinese medicine composition for treating skin eczema and herpes. 20-40 parts by weight of pine, 10-30 parts by weight of honeysuckle, 10-30 parts by weight of wild chrysanthemum, 40-60 parts by weight of Baiying, 15-35 parts by weight of realgar, 20-40 parts by weight of mint, 20-40 parts by weight of raw Burnet parts, 120-140 parts by weight of sesame oil, 40-60 parts by weight of fresh barley root, 20-40 parts by weight of root of Polygonum cuspidatum, 25-45 parts by weight of alum, 5-25 parts by weight of castor bean and 20-40 parts by weight of Radix Hibiscus.

所述的治疗皮肤湿疹疱疹的中药组合物,所述组合物的原料药组成为:大叶青根30重量份、大叶桉50重量份、瓦松30重量份、金银花20重量份、野菊花20重量份、白英50重量份、雄黄25重量份、薄荷30重量份、生地榆30重量份、麻油130重量份、鲜杠板归50重量份、虎杖根30重量份、明矾35重量份、蓖麻子15重量份和羊蹄根30重量份。The traditional Chinese medicine composition for treating skin eczema and herpes, the raw materials of the composition are composed of: 30 parts by weight of Echinacea Echinacea, 50 parts by weight of Eucalyptus eucalyptus, 30 parts by weight of Vasong, 20 parts by weight of honeysuckle, 20 parts by weight of wild chrysanthemum Parts by weight, 50 parts by weight of Bai Ying, 25 parts by weight of realgar, 30 parts by weight of peppermint, 30 parts by weight of raw Burnet, 130 parts by weight of sesame oil, 50 parts by weight of fresh barley root, 30 parts by weight of Polygonum cuspidatum root, 35 parts by weight of alum, castor 15 parts by weight of pockmark and 30 parts by weight of root of sheep's trotter.

所述的治疗皮肤湿疹疱疹的中药组合物按照常规工艺加入常规辅料制成临床上可接受的外用制剂。The traditional Chinese medicine composition for treating skin eczema and herpes is prepared into a clinically acceptable external preparation by adding conventional auxiliary materials according to conventional techniques.

本发明提供了一种采用上述的药物组合物加入常规辅料按照常规工艺制备得到的外用制剂。The invention provides an external preparation prepared by adding the above-mentioned pharmaceutical composition and conventional auxiliary materials according to a conventional process.

所述外用制剂包括喷剂、搽剂、膏剂、糊剂、洗剂或贴剂。The external preparations include sprays, liniments, ointments, pastes, lotions or patches.

本发明提供了一种制备所述治疗皮肤湿疹疱疹的中药组合物的方法,该方法包括如下步骤:The invention provides a method for preparing the Chinese medicine composition for treating skin eczema herpes, the method comprising the steps of:

(a)按照选定的重量份数取大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根,分别粉碎成细粉后混合或混合后粉碎成细粉,过筛备用;(a) according to the selected parts by weight, take Echinacea Echinacea, Eucalyptus euphratica, Vasong, honeysuckle, wild chrysanthemum, Baiying, realgar, peppermint, raw burnet, fresh barley, Polygonum cuspidatum root, alum, castor bean and The root of sheep's trotter is crushed into fine powder and mixed or mixed and crushed into fine powder, and sieved for later use;

(b)取上述细粉,加入选定重量份数的麻油,然后加入常规辅料按照常规工艺制成临床上可接受的喷剂、搽剂、膏剂、糊剂、洗剂或贴剂。(b) Take the above fine powder, add sesame oil in selected parts by weight, and then add conventional auxiliary materials to make clinically acceptable sprays, liniments, ointments, pastes, lotions or patches according to conventional processes.

本发明提供了一种制备上述治疗皮肤湿疹疱疹的中药组合物的方法,该方法包括如下步骤:The invention provides a method for preparing the above-mentioned Chinese medicine composition for treating skin eczema and herpes, the method comprising the steps of:

(a)按照选定重量份数取大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、麻油、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根混合,加水煎煮,滤过并合并滤液,取上清液浓缩浸膏;(a) according to the selected parts by weight, take Echinacea Echinacea, Eucalyptus eucalyptus, Vasong, honeysuckle, wild chrysanthemum, Baiying, realgar, peppermint, raw Burnet, sesame oil, fresh barley, Polygonum cuspidatum root, alum, castor bean Mix with the root of the sheep's trotter, add water to decoct, filter and combine the filtrate, and take the supernatant to concentrate the extract;

(b)取所述浸膏,加入常规辅料按照常规工艺制成临床上可接受的喷剂、搽剂、膏剂、糊剂、洗剂或贴剂。(b) Take the extract, add conventional auxiliary materials and make clinically acceptable sprays, liniments, ointments, pastes, lotions or patches according to conventional processes.

本发明提供了一种制备上述治疗皮肤湿疹疱疹的中药组合物的方法,该方法包括如下步骤:The invention provides a method for preparing the above-mentioned Chinese medicine composition for treating skin eczema and herpes, the method comprising the steps of:

按照选定重量份数取大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、麻油、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根混合粉碎,加乙醇提取得醇提液,减压浓缩除醇后,加入常规辅料,按照常规工艺制成临床上可接受的喷剂、搽剂、膏剂、糊剂、洗剂或贴剂。According to the selected parts by weight, take Echinacea Echinacea, Eucalyptus euphratica, Vasong, Honeysuckle, Wild Chrysanthemum, Baiying, Realgar, Peppermint, Raw Burnet, Sesame Oil, Fresh Pangui, Polygonum cuspidatum root, alum, castor bean and sheep’s foot root Mix and pulverize, add ethanol to extract to obtain alcohol extract, concentrate under reduced pressure to remove alcohol, add conventional excipients, and make clinically acceptable sprays, liniments, ointments, pastes, lotions or patches according to conventional processes.

本发明由上述的方法制备得到中药组合物。The present invention prepares the traditional Chinese medicine composition by the above-mentioned method.

本发明提供了一种中药组合物在制备治疗皮肤湿疹疱疹的药物中的应用。The invention provides an application of a traditional Chinese medicine composition in preparing a medicine for treating skin eczema and herpes.

本发明所述的治疗皮肤湿疹疱疹的中药组合物,通过选取大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、麻油、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根为原料药制成的中药组合物在治疗皮肤湿疹疱疹方面具有显著的治疗效果,见效快,费用低,使用方便,临床治愈率高达98.3%。The traditional Chinese medicine composition for treating skin eczema and herpes according to the present invention is obtained by selecting Echinacea Echinacea, Eucalyptus euphratica, Vasong, honeysuckle, wild chrysanthemum, Baiying, realgar, peppermint, raw Burnet, sesame oil, fresh bark root, Polygonum cuspidatum The traditional Chinese medicine composition made of root, alum, castor bean and Radix chinensis has remarkable curative effect in treating skin eczema herpes, quick effect, low cost, easy to use, and the clinical cure rate is as high as 98.3%.

实验例本发明中药组合物治疗皮肤湿疹疱疹的临床观察Clinical observation of experimental example Chinese medicine composition of the present invention treating skin eczema herpes

1、资料与方法1. Materials and methods

临床资料:本发明对120例患有皮肤湿疹疱疹的患者进行临床观察。Clinical data: the present invention carries out clinical observation on 120 patients suffering from skin eczema herpes.

临床治疗效果的评价标准为:The evaluation criteria of clinical treatment effect are:

(1)临床治愈:原有症状消失;(1) Clinical cure: the original symptoms disappear;

(2)显效:原有症状部分消失;(2) Significant effect: the original symptoms partially disappear;

(3)好转:原有病情有所减轻;(3) Improvement: the original condition has been alleviated;

(4)无效:症状体征无变化。(4) Ineffective: no change in symptoms and signs.

给药方法:分别取实施例1制备的喷剂和实施例3制备的糊剂适量喷于或涂覆于患者的患病处,每15天一疗程,每天2次。Administration method: Take the spray prepared in Example 1 and the paste prepared in Example 3 to spray or apply an appropriate amount on the patient's diseased part, every 15 days for a course of treatment, twice a day.

2、治疗结果2. Treatment results

使用本发明实施例1制备的中药组合物治疗2-3个疗程后,观察60例患者的皮肤湿疹疱疹的治疗结果,其中治愈59例,显效1例,好转0例,无效0例,治愈率为98.3%。After using the traditional Chinese medicine composition prepared in Example 1 of the present invention to treat 2-3 courses of treatment, observe the treatment results of 60 patients with skin eczema herpes, wherein 59 cases were cured, 1 case was markedly effective, 0 cases were improved, and 0 cases were ineffective. 98.3%.

使用本发明实施例3制备的中药组合物治疗2-3个疗程后,观察60例患者的皮肤湿疹疱疹的治疗结果,其中治愈57例,显效2例,好转1例,无效0例,治愈率为95%。After using the traditional Chinese medicine composition prepared in Example 3 of the present invention to treat 2-3 courses of treatment, observe the treatment results of 60 patients with skin eczema herpes, wherein 57 cases were cured, 2 cases were markedly effective, 1 case was improved, and 0 cases were invalid. 95%.

毒副作用:在治疗结束后,复查血尿常规、大便、心、肝和肾功能未发现异常改变。3个月后对上述病例进行回访,无复发患者。Toxic and side effects: After the treatment, reexamination of blood and urine routine, stool, heart, liver and kidney function found no abnormal changes. After 3 months, the above-mentioned cases were visited, and there was no relapse patient.

3、结论3. Conclusion

(1)本发明所述的中药组合物在治疗皮肤湿疹疱疹等方面具有显著的治疗效果,其治愈率可达98.3%,疗程短,见效快,且无毒副作用。(1) The traditional Chinese medicine composition of the present invention has a remarkable therapeutic effect in the treatment of skin eczema and herpes, and its cure rate can reach 98.3%, with a short course of treatment, quick results, and no toxic or side effects.

具体实施方式detailed description

实施例1喷剂剂型Embodiment 1 spray dosage form

本实施例的治疗皮肤湿疹疱疹的中药组合物,其配方如下:The Chinese medicine composition for the treatment of skin eczema herpes of the present embodiment, its formula is as follows:

大叶青根20g、大叶桉60g、瓦松20g、金银花30g、野菊花10g、白英60g、雄黄15g、薄荷40g、生地榆20g、麻油140g、鲜杠板归40g、虎杖根40g、明矾25g、蓖麻子25g和羊蹄根20g。20g of Echinacea root, 60g of Eucalyptus eucalyptus, 20g of pine, 30g of honeysuckle, 10g of wild chrysanthemum, 60g of bletilla, 15g of realgar, 40g of mint, 20g of raw Burnet, 140g of sesame oil, 40g of fresh barbel, 40g of knotweed root, 25g of alum , 25g of castor beans and 20g of sheep's trotter root.

所述中药组合物按照以下步骤制备成喷剂:The Chinese medicine composition is prepared into a spray according to the following steps:

(a)按照选定的重量份数取大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根,分别粉碎成细粉后混合或混合后粉碎成细粉,过40目筛备用;(a) according to the selected parts by weight, take Echinacea Echinacea, Eucalyptus euphratica, Vasong, honeysuckle, wild chrysanthemum, Baiying, realgar, peppermint, raw burnet, fresh barley, Polygonum cuspidatum root, alum, castor bean and The root of sheep's trotter is crushed into fine powder and mixed or mixed and crushed into fine powder, and passed through a 40-mesh sieve for later use;

(b)取上述细粉,加入选定重量份数的麻油,然后加入常规辅料按照常规工艺制成临床上可接受的喷剂。(b) Take the above fine powder, add sesame oil in selected parts by weight, and then add conventional auxiliary materials to prepare a clinically acceptable spray according to conventional processes.

实施例2搽剂剂型Embodiment 2 liniment formulation

本实施例的治疗皮肤湿疹疱疹的中药组合物,其配方如下:The Chinese medicine composition for the treatment of skin eczema herpes of the present embodiment, its formula is as follows:

大叶青根40g、大叶桉40g、瓦松40g、金银花10g、野菊花30g、白英40g、雄黄35g、薄荷20g、生地榆40g、麻油120g、鲜杠板归60g、虎杖根20g、明矾45g、蓖麻子5g和羊蹄根40g。40g of Echinacea root, 40g of Eucalyptus eucalyptus, 40g of pine, 10g of honeysuckle, 30g of wild chrysanthemum, 40g of bletilla, 35g of realgar, 20g of mint, 40g of raw Burnet, 120g of sesame oil, 60g of fresh barbel, 20g of root of Polygonum cuspidatum, 45g of alum , 5g of castor beans and 40g of sheep's trotter root.

所述中药组合物按照以下步骤制备成搽剂:Described Chinese medicine composition is prepared into liniment according to the following steps:

(a)按照选定的重量份数取大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根,分别粉碎成细粉后混合或混合后粉碎成细粉,过400目筛备用;(a) according to the selected parts by weight, take Echinacea Echinacea, Eucalyptus euphratica, Vasong, honeysuckle, wild chrysanthemum, Baiying, realgar, peppermint, raw burnet, fresh barley, Polygonum cuspidatum root, alum, castor bean and The root of sheep's trotter is crushed into fine powder and mixed or mixed and crushed into fine powder, and passed through a 400-mesh sieve for later use;

(b)取上述细粉,加入选定重量份数的麻油,然后加入常规辅料按照常规工艺制成临床上可接受的搽剂。(b) Take the above fine powder, add sesame oil in selected parts by weight, and then add conventional auxiliary materials to prepare a clinically acceptable liniment according to conventional techniques.

实施例3糊剂剂型Embodiment 3 paste dosage form

本实施例的治疗皮肤湿疹疱疹的中药组合物,其配方如下:The Chinese medicine composition for the treatment of skin eczema herpes of the present embodiment, its formula is as follows:

大叶青根30g、大叶桉50g、瓦松30g、金银花20g、野菊花20g、白英50g、雄黄25g、薄荷30g、生地榆30g、麻油130g、鲜杠板归50g、虎杖根30g、明矾35g、蓖麻子15g和羊蹄根30g。30g of Echinacea root, 50g of Eucalyptus eucalyptus, 30g of pine, 20g of honeysuckle, 20g of wild chrysanthemum, 50g of bletilla, 25g of realgar, 30g of mint, 30g of raw Burnet, 130g of sesame oil, 50g of fresh bark, 30g of root of knotweed, 35g of alum , 15g of castor beans and 30g of sheep's trotter root.

所述中药组合物按照以下步骤制备成糊剂:The Chinese medicine composition is prepared into a paste according to the following steps:

(a)按照选定的重量份数取大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根,分别粉碎成细粉后混合或混合后粉碎成细粉,过200目筛备用;(a) according to the selected parts by weight, take Echinacea Echinacea, Eucalyptus euphratica, Vasong, honeysuckle, wild chrysanthemum, Baiying, realgar, peppermint, raw burnet, fresh barley, Polygonum cuspidatum root, alum, castor bean and The root of sheep's trotter is crushed into fine powder and mixed or mixed and crushed into fine powder, and passed through a 200-mesh sieve for later use;

(b)取上述细粉,加入选定重量份数的麻油,然后加入常规辅料按照常规工艺制成临床上可接受的糊剂。(b) Take the above-mentioned fine powder, add sesame oil in selected parts by weight, and then add conventional auxiliary materials to prepare a clinically acceptable paste according to conventional techniques.

实施例4膏剂剂型Embodiment 4 Ointment dosage form

本实施例的治疗皮肤湿疹疱疹的中药组合物,其配方如下:The Chinese medicine composition for the treatment of skin eczema herpes of the present embodiment, its formula is as follows:

大叶青根25g、大叶桉55g、瓦松25g、金银花25g、野菊花15g、白英55g、雄黄20g、薄荷35g、生地榆25g、麻油135g、鲜杠板归45g、虎杖根35g、明矾30g、蓖麻子20g和羊蹄根25g。25g of Echinacea root, 55g of Eucalyptus eucalyptus, 25g of pine, 25g of honeysuckle, 15g of wild chrysanthemum, 55g of bletilla chinensis, 20g of realgar, 35g of mint, 25g of raw Burnet, 135g of sesame oil, 45g of fresh barbel, 35g of knotweed root, 30g of alum , 20g of castor beans and 25g of sheep's trotter root.

所述中药组合物按照以下步骤制备成膏剂:Described Chinese medicine composition is prepared into ointment according to the following steps:

(a)按照选定重量份数取一枝大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、麻油、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根混合,加水煎煮二次,第一次加8倍药物重量的水,煎煮2.5小时,第二次加6倍量水,煎煮2小时,滤过,合并滤液,静置过夜,取上清液浓缩至60℃相对密度为1.2-1.25的浸膏;(a) According to the selected parts by weight, take a branch of Pseudomonas chinensis, Eucalyptus eucalyptus, vasong, honeysuckle, wild chrysanthemum, white hero, realgar, peppermint, raw Burnet, sesame oil, fresh bark, Polygonum cuspidatum root, alum, castor Mix pockmarks and sheep's trotter root, add water to decoct twice, add 8 times the weight of the drug in water for the first time, decoct for 2.5 hours, add 6 times the amount of water for the second time, decoct for 2 hours, filter, combine the filtrate, and let it stand Overnight, take the supernatant and concentrate to an extract with a relative density of 1.2-1.25 at 60°C;

(b)取所述浸膏,加入常规辅料按照常规工艺制成临床上可接受的膏剂。(b) Take the extract, add conventional auxiliary materials and make a clinically acceptable ointment according to conventional techniques.

实施例5贴剂剂型Embodiment 5 patch formulation

本实施例的治疗皮肤湿疹疱疹的中药组合物,其配方如下:The Chinese medicine composition for the treatment of skin eczema herpes of the present embodiment, its formula is as follows:

大叶青根35g、大叶桉45g、瓦松35g、金银花15g、野菊花25g、白英45g、雄黄30g、薄荷25g、生地榆35g、麻油125g、鲜杠板归55g、虎杖根25g、明矾40g、蓖麻子10g和羊蹄根35g。35g of Echinacea root, 45g of Eucalyptus eucalyptus, 35g of pine, 15g of honeysuckle, 25g of wild chrysanthemum, 45g of bletilla, 30g of realgar, 25g of mint, 35g of raw Burnet, 125g of sesame oil, 55g of fresh barbel, 25g of knotweed root, 40g of alum , 10g of castor beans and 35g of sheep's trotter root.

所述中药组合物按照以下步骤制备成贴剂:The Chinese medicine composition is prepared into a patch according to the following steps:

(a)按照选定重量份数取大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、麻油、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根混合,加水煎煮二次,第一次加12倍药物重量的水,煎煮1.5小时,第二次加10倍量水,煎煮1小时,滤过,合并滤液,静置过夜,取上清液浓缩至60℃相对密度为1.2-1.25的浸膏;(a) according to the selected parts by weight, take Echinacea Echinacea, Eucalyptus eucalyptus, Vasong, honeysuckle, wild chrysanthemum, Baiying, realgar, peppermint, raw Burnet, sesame oil, fresh barley, Polygonum cuspidatum root, alum, castor bean Mix with the root of the sheep's trotter, add water to decoct twice, add 12 times the weight of the medicine for the first time, decoct for 1.5 hours, add 10 times the amount of water for the second time, decoct for 1 hour, filter, combine the filtrate, and let it stand overnight , take the supernatant and concentrate it to an extract with a relative density of 1.2-1.25 at 60°C;

(b)取所述浸膏,加入常规辅料按照常规工艺制成临床上可接受的贴剂。(b) Take the extract, add conventional auxiliary materials and make a clinically acceptable patch according to conventional techniques.

实施例6喷剂剂型Embodiment 6 spray formulation

本实施例的治疗皮肤湿疹疱疹的中药组合物,其配方如下:The Chinese medicine composition for the treatment of skin eczema herpes of the present embodiment, its formula is as follows:

大叶青根20g、大叶桉40g、瓦松20g、金银花10g、野菊花10g、白英40g、雄黄15g、薄荷20g、生地榆20g、麻油120g、鲜杠板归40g、虎杖根20g、明矾25g、蓖麻子5g和羊蹄根20g。20g of Echinacea root, 40g of Eucalyptus eucalyptus, 20g of pine, 10g of honeysuckle, 10g of wild chrysanthemum, 40g of bletilla, 15g of realgar, 20g of mint, 20g of raw Burnet, 120g of sesame oil, 40g of fresh barbel, 20g of root of Polygonum cuspidatum, 25g of alum , castor bean 5g and sheep's trotter root 20g.

所述中药组合物按照以下步骤制备成喷剂:The Chinese medicine composition is prepared into a spray according to the following steps:

按照选定重量份数取大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、麻油、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根混合粉碎,加4倍药物重量的55-75%乙醇,浸渍48小时后,对药液加热保持药液温度为30℃~40℃,强制循环3-4小时,过滤,得醇提液,加入常规辅料,按照常规工艺制成临床上可接受的喷剂。According to the selected parts by weight, take Echinacea Echinacea, Eucalyptus euphratica, Vasong, Honeysuckle, Wild Chrysanthemum, Baiying, Realgar, Peppermint, Raw Burnet, Sesame Oil, Fresh Pangui, Polygonum cuspidatum root, alum, castor bean and sheep’s foot root Mix and pulverize, add 55-75% ethanol that is 4 times the weight of the drug, soak for 48 hours, heat the drug solution to keep the temperature of the drug solution at 30°C-40°C, force circulation for 3-4 hours, filter to obtain the alcohol extract, add Conventional excipients are prepared into clinically acceptable sprays according to conventional processes.

实施例7洗剂剂型Embodiment 7 lotion formulation

本实施例的治疗皮肤湿疹疱疹的中药组合物,其配方如下:The Chinese medicine composition for the treatment of skin eczema herpes of the present embodiment, its formula is as follows:

大叶青根40g、大叶桉60g、瓦松40g、金银花30g、野菊花30g、白英60g、雄黄35g、薄荷40g、生地榆40g、麻油140g、鲜杠板归60g、虎杖根40g、明矾45g、蓖麻子25g和羊蹄根40g。40g of Echinacea root, 60g of Eucalyptus eucalyptus, 40g of pine, 30g of honeysuckle, 30g of wild chrysanthemum, 60g of bletilla chinensis, 35g of realgar, 40g of mint, 40g of raw Burnet, 140g of sesame oil, 60g of fresh barbel, 40g of knotweed root, 45g of alum , 25g of castor beans and 40g of sheep's trotter root.

所述中药组合物按照以下步骤制备成洗剂:Described Chinese medicine composition is prepared into lotion according to the following steps:

按照选定重量份数取大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、麻油、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根混合粉碎,加12倍药物重量的55-75%乙醇,浸渍12小时后,对药液加热保持药液温度为30℃~40℃,强制循环3-4小时,过滤,得醇提液,加入常规辅料,按照常规工艺制成临床上可接受的洗剂。According to the selected parts by weight, take Echinacea Echinacea, Eucalyptus euphratica, Vasong, Honeysuckle, Wild Chrysanthemum, Baiying, Realgar, Peppermint, Raw Burnet, Sesame Oil, Fresh Pangui, Polygonum cuspidatum root, alum, castor bean and sheep’s foot root Mix and pulverize, add 55-75% ethanol 12 times the weight of the drug, soak for 12 hours, heat the drug solution to keep the temperature of the drug solution at 30°C-40°C, force circulation for 3-4 hours, filter to obtain the alcohol extract, add Conventional auxiliary materials are prepared into clinically acceptable lotions according to conventional processes.

显然,上述实施例仅仅是为清楚地说明所作的举例,而并非对实施方式的限定。对于所属领域的普通技术人员来说,在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。而由此所引伸出的显而易见的变化或变动仍处于本发明创造的保护范围之中。Apparently, the above-mentioned embodiments are only examples for clear description, rather than limiting the implementation. For those of ordinary skill in the art, other changes or changes in different forms can be made on the basis of the above description. It is not necessary and impossible to exhaustively list all the implementation manners here. And the obvious changes or changes derived therefrom are still within the scope of protection of the present invention.

Claims (9)

1.一种治疗皮肤湿疹和疱疹的中药组合物,其特征在于,所述组合物的原料药组成为:大叶青根20-30重量份、大叶桉40-50重量份、瓦松20-40重量份、金银花20-30重量份、野菊花10-20重量份、白英40-60重量份、雄黄15-35重量份、薄荷20-40重量份、生地榆20-40重量份、麻油120-140重量份、鲜杠板归40-80重量份、虎杖根20-60重量份、明矾25-45重量份、蓖麻子5-25重量份和羊蹄根20-40重量份。1. a Chinese medicine composition for the treatment of skin eczema and herpes, characterized in that, the bulk drug of the composition consists of: 20-30 parts by weight of Radix Echinacea, 40-50 parts by weight of Eucalyptus eucalyptus, 20-30 parts by weight of Vasong 40 parts by weight, 20-30 parts by weight of honeysuckle, 10-20 parts by weight of wild chrysanthemum, 40-60 parts by weight of Baiying, 15-35 parts by weight of realgar, 20-40 parts by weight of peppermint, 20-40 parts by weight of raw Burnet, sesame oil 120-140 parts by weight, 40-80 parts by weight of fresh barley, 20-60 parts by weight of Polygonum cuspidatum root, 25-45 parts by weight of alum, 5-25 parts by weight of castor bean and 20-40 parts by weight of Radix Hibiscus. 2.根据权利要求1所述的治疗皮肤湿疹和疱疹的中药组合物,其特征在于,所述组合物的原料药组成为:大叶青根25重量份、大叶桉45重量份、瓦松30重量份、金银花25重量份、野菊花20重量份、白英50重量份、雄黄25重量份、薄荷30重量份、生地榆30重量份、麻油130重量份、鲜杠板归70重量份、虎杖根50重量份、明矾35重量份、蓖麻子15重量份和羊蹄根30重量份。2. the Chinese medicine composition for the treatment of skin eczema and herpes according to claim 1, characterized in that, the bulk drug of the composition consists of: 25 parts by weight of Echinacea Echinacea, 45 parts by weight of Eucalyptus eucalyptus, 30 parts by weight of Vasong Parts by weight, 25 parts by weight of honeysuckle, 20 parts by weight of wild chrysanthemum, 50 parts by weight of Baiying, 25 parts by weight of realgar, 30 parts by weight of peppermint, 30 parts by weight of raw Burnet, 130 parts by weight of sesame oil, 70 parts by weight of fresh barley, knotweed 50 parts by weight of root, 35 parts by weight of alum, 15 parts by weight of castor bean and 30 parts by weight of root of sheep's foot. 3.采用权利要求1或2所述的药物组合物加入常规辅料按照常规工艺制备得到的外用制剂。3. adopt the pharmaceutical composition described in claim 1 or 2 to add the external preparation that conventional adjuvant is prepared according to conventional process. 4.根据权利要求3所述的外用制剂,其特征在于,所述外用制剂包括喷剂、搽剂、膏剂或洗剂。4. The external preparation according to claim 3, characterized in that the external preparation comprises spray, liniment, ointment or lotion. 5.一种制备如权利要求1或2所述治疗皮肤湿疹和疱疹的中药组合物的方法,其特征在于,该方法包括如下步骤:5. a method for preparing a Chinese medicine composition for treating skin eczema and herpes as claimed in claim 1 or 2, is characterized in that, the method comprises the steps: (a)按照选定的重量份数取大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根,分别粉碎成细粉后混合或混合后粉碎成细粉,过筛备用;(a) according to the selected parts by weight, take Echinacea Echinacea, Eucalyptus euphratica, Vasong, honeysuckle, wild chrysanthemum, Baiying, realgar, peppermint, raw burnet, fresh barley, Polygonum cuspidatum root, alum, castor bean and The root of sheep's trotter is crushed into fine powder and mixed or mixed and crushed into fine powder, and sieved for later use; (b)取上述细粉,加入选定重量份数的麻油,然后加入常规辅料按照常规工艺制成临床上可接受的喷剂、搽剂、膏剂或洗剂。(b) Take the above-mentioned fine powder, add sesame oil in selected parts by weight, and then add conventional auxiliary materials to prepare clinically acceptable spray, liniment, ointment or lotion according to conventional processes. 6.一种制备如权利要求1或2所述治疗皮肤湿疹和疱疹的中药组合物的方法,其特征在于,该方法包括如下步骤:6. a method for preparing a Chinese medicine composition for treating skin eczema and herpes as claimed in claim 1 or 2, is characterized in that, the method comprises the steps: (a)按照选定重量份数取大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、麻油、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根混合,加水煎煮,滤过并合并滤液,取上清液浓缩浸膏;(a) according to the selected parts by weight, take Echinacea chinensis, Eucalyptus eucalyptus, vasong, honeysuckle, wild chrysanthemum, white chrysanthemum, realgar, peppermint, raw burnet, sesame oil, fresh bark, Polygonum cuspidatum root, alum, castor bean Mix with the root of the sheep's trotter, add water to decoct, filter and combine the filtrate, and take the supernatant to concentrate the extract; (b)取所述浸膏,加入常规辅料按照常规工艺制成临床上可接受的喷剂、搽剂、膏剂或洗剂。(b) Take the extract, add conventional auxiliary materials and make clinically acceptable sprays, liniments, ointments or lotions according to conventional processes. 7.一种制备如权利要求1或2所述治疗皮肤湿疹和疱疹的中药组合物的方法,其特征在于,该方法包括如下步骤:7. a method for preparing a Chinese medicine composition for treating skin eczema and herpes as claimed in claim 1 or 2, is characterized in that, the method comprises the steps: 按照选定重量份数取大叶青根、大叶桉、瓦松、金银花、野菊花、白英、雄黄、薄荷、生地榆、麻油、鲜杠板归、虎杖根、明矾、蓖麻子和羊蹄根混合粉碎,加乙醇提取得醇提液,减压浓缩除醇后,加入常规辅料,按照常规工艺制成临床上可接受的喷剂、搽剂、膏剂或洗剂。According to the selected parts by weight, take the root of Echinacea, Eucalyptus eucalyptus, vasong, honeysuckle, wild chrysanthemum, white hero, realgar, peppermint, raw Burnet, sesame oil, fresh barley, knotweed root, alum, castor bean and sheep's foot root Mix and pulverize, add ethanol to extract to obtain alcohol extract, concentrate under reduced pressure to remove alcohol, add conventional excipients, and make clinically acceptable spray, liniment, ointment or lotion according to conventional technology. 8.根据权利要求5-7任一所述的方法制备得到的中药组合物。8. The Chinese medicine composition prepared according to the arbitrary described method of claim 5-7. 9.根据权利要求1或2或8所述的中药组合物在制备治疗皮肤湿疹和疱疹的药物中的应用。9. according to the application of claim 1 or 2 or 8 described Chinese medicine composition in the medicine of preparation treatment skin eczema and herpes.
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