CN103893221A - Antrodia cinnamomea extract liquor for reducing blood alcohol concentration - Google Patents
Antrodia cinnamomea extract liquor for reducing blood alcohol concentration Download PDFInfo
- Publication number
- CN103893221A CN103893221A CN201210586450.4A CN201210586450A CN103893221A CN 103893221 A CN103893221 A CN 103893221A CN 201210586450 A CN201210586450 A CN 201210586450A CN 103893221 A CN103893221 A CN 103893221A
- Authority
- CN
- China
- Prior art keywords
- antrodia camphorata
- oil
- ethanol
- little
- bac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to antrodia cinnamomea extract liquor for reducing blood alcohol concentration. The antrodia cinnamomea extract liquor comprises maleic imide compounds extracted from oil in a cracked cell wall of antrodia cinnamomea mycelium as an effective ingredient, and mixed with a certain amount of edible oil to form a solution form, wherein the edible oil and the effective ingredient are mixed according to the weight ratio of (9:1) to (7:3). Therefore, the activity of alcohol dehydrogenase in the body of a small laboratory rat fed by the antrodia cinnamomea extract liquor disclosed by the invention is obviously increased by about 50-60% relatively, and the alcohol concentration in the blood is also obviously reduced by about 30-40% relatively.
Description
Technical field
The invention relates to a kind of Antrodia camphorata extract that reduces BAC, refer in particular to a kind of ethanol dehydrogenase activity of being responsible for alcohol metabolism that improves, to stimulate alcohol metabolism to reduce the Antrodia camphorata extract of the alcohol concentration in blood.
Background technology
Along with being growing more intense of the development of social diversity and people's economy, operating pressure, drink and become a kind of general behavior, the occasion such as dinner party, family party between business reception, colleague or acquaintance, the chance of drinking also more and more increases, cause many people because drinking frequently and crossing drink and be still drank after a night, and then normal Working Life affect the next day; Being still drank after a night is the human body and the general name of sense of discomfort mentally to occurring after drinking, and its objective symptom has that cognitive competence reduces, nauseating, vomiting, headache, motor capacity reduction etc.
For causing the reason of being still drank after a night, although also do not study completely clear,, have a lot of academic viewpoints to think that its reason is the derivative reaction of toxic action of the metabolite (acetaldehyde, formaldehyde, acetone) because of ethanol and ethanol, main component contained in ethanol is ethanol, therefore after drinking, ethanol will be along with the blood whole body that distributes rapidly, and organ and cell concerning human body, ethanol is noxious substance, need through a series of chemical reaction its metabolism, human body metabolism's mechanism of just understanding at present, few part ethanol can see through breathing or urine mode is discharged, and residue 90-95% ethanol in liver through ethanol dehydrogenase (alcohol dehydrogenase, ADH) convert acetaldehyde to, acetaldehyde is again by acetaldehyde dehydrogenase (aldehyde dehydrogenase, ALHD) be metabolized to acetic acid and carbon dioxide and water and excrete, for persons skilled in the art, the specific activity (specific activity) for the ethanol dehydrogenase of metabolism ethanol in body is promoted, it is rational inference that metabolism that can acceleration of alcohol is got rid of.
General tradition drunkenness dispelling liquid be on the market a kind of after drinking the liquid for reducing alcohol concentration, it is mostly to mix or refine with chemical liquid to form, though can reduce immediately alcohol concentration after drinking, but relatively, after several times of drinking, also having side effect produces, in view of this, the side effect of being harmful to the health and causing for fear of drunkenness dispelling liquid, most user are still to tend to drink with natural plants and refine the drunkenness dispelling liquid forming; At present, for example, can only be called at most vital essence with natural plant extraction thing (: Radix Ginseng, Radix Angelicae Sinensis, Radix Glycyrrhizae, sesamin etc.) or the drunkenness dispelling liquid made from compositions such as vitamin B, vitamin C, aminoacid and mend refreshing healthy beverage, still be not enough to reach real antialcoholism function; And nearly all product or folk prescription all do not have concrete experimental data prove its have reduce drink after effect of BAC, often be considered to unreal doubt, therefore as how wholefood still has the improved space of research and development as the drunkenness dispelling liquid that can reduce alcohol concentration.
Antrodia camphorata (Antrodia camphorata) is a kind of wild mushroom bacterium, is the crude drug plant of a kind of very preciousness and endemic species in the forest of Taiwan; Early stage legend is Taiwan aboriginal in the time felling, and has found unintentionally the Antrodia camphorata on Cinnamomum kanahirai hay tree, and aboriginal is because lifestyle or carefree individual character make so, prefer drink, be still drank after a night unavoidable; But, unexpectedly find that it has the effect of relieving the effect of alcohol drinking after the liquid that boils of Antrodia camphorata, make Antrodia camphorata become traditional valuable ingredient of Chinese medicine of aboriginal; Between the several years in the past, due to Antrodia camphorata pharmacologically active and hypotoxicity speciality widely, it is come into one's own internationally gradually, also paid attention to by the scholar of each side and industry and extract the medicative natural goods of tool by Antrodia camphorata, and various factors based on above-mentioned, using Antrodia camphorata extract as the composition that reduces BAC, be to there is suitable feasibility to improve the symptom of being still drank after a night.
The drunkenness dispelling liquid of making in view of above-mentioned existing natural plant extraction still has the disappearance of many places on reality is implemented, therefore, develop a kind of natural plants and refine the drunkenness dispelling liquid that can effectively reduce BAC obtaining, be still one of this area problem demanding prompt solution.
Summary of the invention
For addressing the above problem, main purpose of the present invention is for a kind of ethanol dehydrogenase activity of being responsible for alcohol metabolism that improves is provided, to stimulate alcohol metabolism to reduce the Antrodia camphorata extract of the alcohol concentration in blood.
In order to achieve the above object, the invention provides a kind of Antrodia camphorata extract that reduces BAC, it comprises oil in the cell wall being broken by Antrodia Camphorata mycelium and extracts the maleimide compound as active ingredient, and mix and be solution shape with an edible oil, wherein this edible oil with this active ingredient with 9: 1-7: 3 weight ratio is mixed; Noticeable, Antrodia camphorata extract of the present invention is take Antrodia Camphorata mycelium powder as raw material, the maleimide compound of purifying in (purify) Antrodia Camphorata mycelium cell wall first by after cell wall breaking, then with oil extraction technology, and be dissolved in edible oil.
The Antrodia camphorata extract of reduction BAC as above, wherein, preferably, described edible oil mixes with the weight ratio of 8: 2 with described active ingredient.
The Antrodia camphorata extract of reduction BAC as above, wherein, described edible oil can be selected from MCT, Semen Maydis oil, olive oil, soybean oil, safflower oil, Oleum Gossypii semen, Oleum Arachidis hypogaeae semen, Oleum sesami, Oleum Helianthi, Oleum Vitis viniferae with and composition thereof the group that formed.
Thus, the little guinea pig of feeding Antrodia camphorata extract of the present invention, in its body, the activity of ethanol dehydrogenase increases about 50-60% significantly relatively, and blood alcohol concentration also reduces about 30-40% significantly relatively, rationally inference Antrodia camphorata extract of the present invention is the ethanol dehydrogenase activity of being responsible for alcohol metabolism by improving, stimulates alcohol metabolism to reduce the alcohol concentration in blood; In addition, the present invention has for expection the Antrodia camphorata composition of BAC of reduction and further implements animal experiment, supports particularly Antrodia camphorata extract of the present invention can reduce effect of BAC after edible ethanol.
Accompanying drawing explanation
Fig. 1 is take ursolic acid as triterpenes standard substance, with the quantitative approach in description, and the standard substance curve chart of drafting;
Fig. 2 is the little guinea pig forfeiture and the design sketch that recovers the righting response time that records feeding ethanol with sterile distilled water, edible oil and Antrodia camphorata extract;
Fig. 3 is the design sketch that records little guinea pig BAC in all experimental grouies and matched group;
Fig. 4 is in the design sketch of not mouthful not feeding and mouthful feeding the experimental group of ethanol and matched group and record ethanol dehydrogenase activity in little guinea pig body.
The specific embodiment
The invention relates to one and can increase human body ethanol dehydrogenase activity, and then the Antrodia camphorata extract of reduction BAC, it includes oil in the cell wall being broken by Antrodia Camphorata mycelium and extracts the maleimide compound as active ingredient, and mix and be solution shape with an edible oil, wherein this edible oil with this active ingredient with 9: 1-7: 3 weight ratio is mixed (preferably, this mass ratio is 8: 2); Wherein, edible oil can be selected from MCT (medium-chaintriglyceride, MCT oil), Semen Maydis oil, olive oil, soybean oil, safflower oil, Oleum Gossypii semen, Oleum Arachidis hypogaeae semen, Oleum sesami, Oleum Helianthi, Oleum Vitis viniferae with and composition thereof the group that formed; Noticeable, Antrodia camphorata extract of the present invention is take Antrodia Camphorata mycelium powder as raw material, first by after cell wall breaking, again with the maleimide compound in oil extraction technology purification Antrodia Camphorata mycelium cell wall, and be dissolved in edible oil, with respect to pulverous Antrodia Camphorata mycelium, it has preferably absorbance and effect.Concrete oil extraction mode is after Antrodia Camphorata mycelium is mixed with edible oil, make cell wall rupture via homogenizer, again the Antrodia Camphorata mycelium after homogenizing being placed in to ultrasound board extracts, use subsequently high speed centrifuge that cell debris is separated with extract, then analyze the content of maleimide compound in above-mentioned extract.Extracting the maleimide compound is to belong to total triterpenes compound (Triterpenoids); Wherein, total triterpenes compound also includes the similar derivant of chemical constitution with maleimide compound, for example ursolic acid (ursolic acid), betulic acid (betulinic acid), Betulonic acid (betulonic acid), 3-isobutyl group-4-[4-(3-methyl-2-butene oxygen base) phenyl]-1H-pyrroles-2,5-diketone and 3-isobutyl group-4-[4-(3-methyl-2-butene oxygen base) phenyl]-1H-pyrroles-1-alcohol-2,5-dione compounds etc.The effective component content comprising in above-mentioned analysis Antrodia camphorata extract is undertaken by following methods: first, get 0.125g Antrodia Camphorata mycelium extract and add 40mL anhydrous alcohol, with reflux extraction 8 hours; Again the extract after 1mL reflux extraction is placed in to sample bottle, blows to dry with ventilated chamber; Afterwards, add the vanillin-glacial acetic acid of 0.4mL (mass concentration 5%), then add the chloric acid of crossing of 0.8mL; Then, said mixture is with 60 ℃ of heating in water bath 15 minutes, then with 4 ℃ cooling 2 minutes, and then add 5mL glacial acetic acid, leave standstill 10 minutes; After above step completes, survey the light absorption value of gained mixture at wavelength 550nm; Refer to shown in Fig. 1, Fig. 1 be with ursolic acid as triterpenes standard substance, and the standard curve of drawing with said method, and the actual testing result total triterpenes of the present invention compounds content is 6.7wt%.
In addition, then according to following experiment, can confirm that Antrodia camphorata extract of the present invention has remarkable increase ethanol dehydrogenase active and reduce effect of BAC, first, carry out forfeiture righting response (loss of rightingreflex, the LORR) test of little guinea pig, in order to simulate drunk time and the time of awaking from a drunken sleep after little guinea pig is drunk, every weight of little guinea pig (ICR strain) of the present invention's test is 26-30 g, its raising temperature is that 25 ± 1 ℃, relative humidity are 65 ± 5% and are maintained at the light switching for 12 hours and secretly circulate, with feedstuff (the Laboratory Rodent Diet of standard laboratory grade, PMT Feed, St.Louis, U, S, A) feeding, the not supply of limiting feed and water between feeding period, the raising condition of little guinea pig all follows the related experiment the care of animal guide of NIH's bulletin to carry out, after 12 hours, it is divided at random to three groups in all little guinea pig fasting, one group is matched group, and another two groups is experimental group, and every group at least has 4 little guinea pigs, test model is the sterile distilled water of the little guinea pig mouth in matched group being fed to every 10 g of body weight 0.08mL, and the edible oil (mct oil) of the little guinea pig mouth in an experimental group being fed to every 10 g of body weight 0.08mL, and the little guinea pig mouth of another experimental group is fed the Antrodia camphorata extract of the reduction BAC of the present invention of every 10 g of body weight 0.08mL, , after 30 minutes, every above-mentioned little guinea pig 10 g of body weight mouths are fed to the ethanol 0.15mL of percentage by volume 52%, and the forfeiture righting response of little guinea pig is observed in interval, in the time that little guinea pig is lost righting response ability really, be the drunk time (being the hatched example areas of strip figure in Fig. 2), and in abdominal part state upward under continuation observation drunk little guinea pig again, when recovering righting response ability (in defining 1 minute, little guinea pig can right more than 3 times voluntarily) the required time, little guinea pig is considered as the time of awaking from a drunken sleep (being the dotted region of strip figure in Fig. 2), refer to shown in Fig. 2, Fig. 2 is with sterile distilled water, edible oil and Antrodia camphorata extract record the little guinea pig of feeding ethanol and lose the righting response ability time and recover the design sketch of righting response ability time, can know and find out by Fig. 2, the little guinea pig of feeding Antrodia camphorata extract of the present invention delays to lose righting response (delaying drunk), approximately can extend the time of two times, and only the little guinea pig of feeding sterile distilled water or edible oil its lose righting response time approximately between 30-40 minute, the time that the little guinea pig of feeding Antrodia camphorata extract of the present invention is lost righting response is approximately two double-lengths of matched group, moreover, only its recovery righting response required time of ability of the little guinea pig of feeding sterile distilled water or edible oil is about 300 minutes, and its recovery righting response required time of ability of the little guinea pig of feeding Antrodia camphorata extract of the present invention only needs 100 minutes, this significantly shortens the drunk time of little guinea pig, promote the relieving alcoholic intoxication ability of little guinea pig, thus result can inference Antrodia camphorata extract of the present invention for the little guinea pig after feed ethanol, have and delay drunk and recover in advance clear-headed remarkable efficacy.
Moreover, little guinea pig is carried out to the analysis of experiments of blood alcohol concentration and ethanol dehydrogenase activity, similarly, every weight of little guinea pig (ICR strain) of this test is 26-30 g, its raising temperature is that 25 ± 1 ℃, relative humidity are 65 ± 5% and are maintained at illumination in 12 hours, 12 hours dark physiological situations, with the feedstuff feeding of standard laboratory grade, the not supply of limiting feed and water between feeding period, the raising condition of little guinea pig all follows the related experiment the care of animal guide of NIH's bulletin to carry out, in all little guinea pig fasting after 12 hours, it is divided into six groups at random, be respectively matched group, sterile distilled water group, Antrodia camphorata extract group, ethanol+sterile distilled water group, ethanol+Antrodia camphorata extract group, and Antrodia camphorata extract+sterile distilled water group, every group at least has 3 little guinea pigs, wherein, matched group does not provide any feeding, sterile distilled water group mouth is fed the sterile distilled water of the every 10 g of body weight 0.08mL of mouse, Antrodia camphorata extract group mouth is fed the Antrodia camphorata extract of the reduction BAC of the present invention of the every 10 g of body weight 0.08mL of mouse, ethanol+sterile distilled water group is fed in mouth after the sterile distilled water of the every 10 g of body weight 0.08mL of mouse, 30 minutes, interval, the every 10 g of body weight mouths of feeding mouse are fed the ethanol 0.15mL of percentage by volume 52%, and ethanol+Antrodia camphorata extract group is fed in mouth after the Antrodia camphorata extract of the present invention of the every 10 g of body weight 0.08mL of mouse, 30 minutes, interval, the every 10 g of body weight mouths of feeding mouse are fed the ethanol 0.15mL of percentage by volume 52% again, this test model be after feeding through 60 minutes, analyze alcohol concentration and ethanol dehydrogenase activity in little guinea pig serum, refer to shown in Fig. 3, Fig. 3 is the little guinea pig alcohol content in blood that the experimental group (comprising matched group) of not mouthful hello ethanol and the experimental group of mouthful hello ethanol record, can be known and be found out by Fig. 3, Antrodia camphorata extract of the present invention can reduce the content of ethanol in mouse body inner blood really, and the little guinea pig of feeding Antrodia camphorata extract of the present invention, in its body inner blood, alcohol content reduces many (30-40%) significantly relatively, in addition, refer to shown in Fig. 4, Fig. 4 is the design sketch that the experimental group (comprising matched group) of not mouthful not feeding ethanol and mouthful feeding ethanol records ethanol dehydrogenase activity in little guinea pig body, can know and find out by Fig. 4, Antrodia camphorata extract of the present invention can increase the activity of ethanol dehydrogenase in mouse body really, meeting current alcohol metabolism reaction need make its accelerated decomposition to convert the inference of acetaldehyde to via ethanol dehydrogenase, and the little guinea pig of feeding Antrodia camphorata extract of the present invention, in its body, the activity of ethanol dehydrogenase increases many (50-60%) significantly relatively, and according to current alcohol metabolism inference, ethanol is mainly to be absorbed by digestive tract, being absorbed in the ethanol in body has 90-95% to carry out metabolism at liver, remaining 5-10% can excrete via expiration, urine and antiperspirant, enter the ethanol of liver by blood, the ethanol dehydrogenase being generated by liver is oxidized to acetaldehyde, and acetaldehyde is oxidized to the acetic acid harmless to health by acetaldehyde dehydrogenase again and excretes, thus, rationally inference Antrodia camphorata extract of the present invention can increase ethanol dehydrogenase activity really, and then reduces effect of blood alcohol concentration, noticeable, although the pharmacological mechanism of Antrodia camphorata extract of the present invention is not clearly set up, rationally inference Antrodia camphorata extract of the present invention can, by improving the ethanol dehydrogenase activity of being responsible for alcohol metabolism, stimulate alcohol metabolism to reduce the alcohol concentration in blood.
From above-mentioned experimental result explanation, in comparison, the present invention has the following advantages for the present invention and prior art:
1, the Antrodia camphorata extract of reduction BAC of the present invention can stimulate the more highly active ethanol dehydrogenase of hepatic secretion to carry out alcohol metabolism after drinking, with do not cast Antrodia camphorata extract of the present invention and compare down, rate reduction BAC faster, thereby reduce the toxic effect of ethanol to liver.
2, the composition that the Antrodia camphorata extract of reduction BAC of the present invention has reduction BAC for expection is further implemented animal experiment, supports particularly effect that is reduced in the BAC after edible spirituosity material of the present invention.
In sum, the Antrodia camphorata extract of reduction BAC of the present invention, can pass through above-mentioned disclosed embodiment really, reaches desired use effect.
But above-mentioned disclosed accompanying drawing and explanation, be only the preferred embodiments of the present invention, not for limiting protection scope of the present invention; All persons skilled in the art are according to content of the present invention, and other equivalence of doing changes or modifies, and all should be considered as not departing from protection scope of the present invention.
Claims (3)
1. one kind is reduced the Antrodia camphorata extract of BAC, it comprises oil in the cell wall being broken by Antrodia Camphorata mycelium and extracts the maleimide compound as effective ingredient, and mix and be solution shape with an edible oil, wherein, described edible oil is with 9 with described effective ingredient: 1-7: 3 weight ratio is mixed.
2. the Antrodia camphorata extract of reduction BAC as claimed in claim 1, wherein, described edible oil is to mix with the weight ratio of 8: 2 with described effective ingredient.
3. the Antrodia camphorata extract of reduction BAC as claimed in claim 1, wherein, described edible oil be selected from MCT, Semen Maydis oil, olive oil, soybean oil, safflower oil, Oleum Gossypii semen, Oleum Arachidis hypogaeae semen, Oleum sesami, Oleum Helianthi, Oleum Vitis viniferae with and composition thereof the group that formed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210586450.4A CN103893221B (en) | 2012-12-28 | Reduce the Antrodia camphorata extract of BAC |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210586450.4A CN103893221B (en) | 2012-12-28 | Reduce the Antrodia camphorata extract of BAC |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103893221A true CN103893221A (en) | 2014-07-02 |
| CN103893221B CN103893221B (en) | 2016-11-30 |
Family
ID=
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021147394A (en) * | 2020-03-18 | 2021-09-27 | 緑茵生技股▲ふん▼有限公司Greenyn Biotechnology Co., Ltd | Application of using taiwanofungus camphoratus for dissolving drunkenness and/or increasing alcohol metabolism |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101417934A (en) * | 2007-10-24 | 2009-04-29 | 国鼎生物科技股份有限公司 | New compounds separated from Antrodia camphorate extract |
| CN101555436A (en) * | 2009-05-15 | 2009-10-14 | 深圳市中科海外科技有限公司 | Method for extracting antrodia cinnamomea oil from antrodia cinnamomea mycelia |
| CN102755355A (en) * | 2011-04-28 | 2012-10-31 | 丽丰实业股份有限公司 | Drug composition resisting influenza virus A or enterovirus |
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101417934A (en) * | 2007-10-24 | 2009-04-29 | 国鼎生物科技股份有限公司 | New compounds separated from Antrodia camphorate extract |
| CN101555436A (en) * | 2009-05-15 | 2009-10-14 | 深圳市中科海外科技有限公司 | Method for extracting antrodia cinnamomea oil from antrodia cinnamomea mycelia |
| CN102755355A (en) * | 2011-04-28 | 2012-10-31 | 丽丰实业股份有限公司 | Drug composition resisting influenza virus A or enterovirus |
Non-Patent Citations (1)
| Title |
|---|
| 马刚等: "樟芝挥发油的提取及其GC_MS分析与抑菌作用的研究", 《西南农业学报》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021147394A (en) * | 2020-03-18 | 2021-09-27 | 緑茵生技股▲ふん▼有限公司Greenyn Biotechnology Co., Ltd | Application of using taiwanofungus camphoratus for dissolving drunkenness and/or increasing alcohol metabolism |
| CN113491720A (en) * | 2020-03-18 | 2021-10-12 | 绿茵生技股份有限公司 | Application of antrodia camphorata for relieving alcoholism and/or increasing alcohol metabolism |
| TWI783217B (en) * | 2020-03-18 | 2022-11-11 | 綠茵生技股份有限公司 | Uses of Antrodia Cinnamomea for Hangover and/or Increase Alcohol Metabolism |
| JP7244945B2 (en) | 2020-03-18 | 2023-03-23 | 緑茵生技股▲ふん▼有限公司 | Uses of Antrodia cinnamomum to relieve drunkenness and/or increase alcohol metabolism |
| US11759488B2 (en) | 2020-03-18 | 2023-09-19 | Greenyn Biotechnology Co., Ltd | Use of antrodia cinnamomea for increasing alcohol metabolism |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Bartram | Bartram's encyclopedia of herbal medicine | |
| Havinga et al. | Tamarindus indica L.(Fabaceae): patterns of use in traditional African medicine | |
| Halpern | Healing mushrooms | |
| CN101889679B (en) | Composition with disintoxicating and liver-protecting effects and application thereof in food and health-care food | |
| Husen | Exploring Poisonous Plants: Medicinal Values, Toxicity Responses, and Therapeutic Uses | |
| Adodo et al. | Healing plants of Nigeria: Ethnomedicine and therapeutic applications | |
| Halpern et al. | Medicinal mushrooms: Ancient remedies for modern ailments | |
| De Gezelle | Q’eqchi’Maya reproductive ethnomedicine | |
| Yuhlung et al. | Indigenous medicinal plants used by the Maring tribe of Manipur, Northeast India | |
| CN101352237B (en) | Health care product and preparation method thereof | |
| Upreti et al. | Ethnolichenological studies in India: future prospects | |
| CN103893221B (en) | Reduce the Antrodia camphorata extract of BAC | |
| CN103893221A (en) | Antrodia cinnamomea extract liquor for reducing blood alcohol concentration | |
| CN103932179B (en) | A kind of health food and two-step fermentation preparation method thereof releasing the pressure and protect liver | |
| CN105030952B (en) | A kind of composition is preparing the application in preventing urinary calculus drug | |
| CN103478843B (en) | A kind of alcohol-decomposing beverage and preparation method thereof | |
| TW201808318A (en) | An herbal composition for improving alcohol intoxication and a use of the herbal composition thereof | |
| Fulder et al. | Garlic: Nature's Original Remedy | |
| Karmakar et al. | Exploration of Anthelmintic, Blood Coagulant, Diuretic and Laxative Activities of Different Solvent Fractions of Flagellaria Indica Leaves | |
| Nwankudu et al. | In vitro investigation of fresh juices of ripe Ananas comosus (pineapple), Carica papaya (pawpaw) and Citrullus vulgaris (watermelon) for uterine contractile properties in non-pregnant rats | |
| Wairimu | Evaluation of Contractile Effects of Uvariodendron Kirkii (Verdec.) Extracts on Isolated Uterine Strips of Female Wistar Rats | |
| Vasey | Natural Remedies for Inflammation | |
| Harrington | Samoan medicinal plants and their usage | |
| Behrens | Lost in Lyme: The Therapeutic Use of Medicinal Plants in Supporting People with Lyme Disease | |
| Wulff et al. | Herbs for Pets: The Natural Way to Enhance Your Pet's Life |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |