CN103875690A - Propineb and metalaxyl-M compound bactericidal composition - Google Patents
Propineb and metalaxyl-M compound bactericidal composition Download PDFInfo
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- CN103875690A CN103875690A CN201410112205.9A CN201410112205A CN103875690A CN 103875690 A CN103875690 A CN 103875690A CN 201410112205 A CN201410112205 A CN 201410112205A CN 103875690 A CN103875690 A CN 103875690A
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- metalaxyl
- propineb
- downy mildew
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- 239000005823 Propineb Substances 0.000 title claims abstract description 46
- 239000005808 Metalaxyl-M Substances 0.000 title claims abstract description 45
- KKMLIVYBGSAJPM-UHFFFAOYSA-L propineb Chemical compound [Zn+2].[S-]C(=S)NC(C)CNC([S-])=S KKMLIVYBGSAJPM-UHFFFAOYSA-L 0.000 title claims abstract description 45
- 239000000203 mixture Substances 0.000 title claims abstract description 32
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 18
- -1 metalaxyl-M compound Chemical class 0.000 title claims abstract description 7
- ZQEIXNIJLIKNTD-GFCCVEGCSA-N metalaxyl-M Chemical compound COCC(=O)N([C@H](C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-GFCCVEGCSA-N 0.000 claims abstract description 39
- 241000233679 Peronosporaceae Species 0.000 claims abstract description 26
- 239000000375 suspending agent Substances 0.000 claims abstract description 11
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- 201000010099 disease Diseases 0.000 claims description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 239000003899 bactericide agent Substances 0.000 claims description 10
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- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 241000256844 Apis mellifera Species 0.000 description 1
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- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical group NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 1
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- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000258937 Hemiptera Species 0.000 description 1
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
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- 229910000278 bentonite Inorganic materials 0.000 description 1
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- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
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- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
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- ZQEIXNIJLIKNTD-UHFFFAOYSA-N methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate Chemical compound COCC(=O)N(C(C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-UHFFFAOYSA-N 0.000 description 1
- 230000003641 microbiacidal effect Effects 0.000 description 1
- 229940124561 microbicide Drugs 0.000 description 1
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- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a propineb and metalaxyl-M compound bactericidal composition which is prepared by compounding propineb with metalaxyl-M. The compound bactericidal composition can be in the form of wettable powder, a suspending agent or water dispersible granules. The composition is mainly used for controlling downy mildew of flowers, cabbages and cucumbers, early and late blight of tomatoes and downy mildew, early blight, late blight, downy mildew blight and the like of various crops. A field test shows that the control effect of the composition is more than 80% and is remarkably superior to that of any one of propineb and metalaxyl-M.
Description
Technical field
The invention belongs to disinfectant use in agriculture field, particularly a kind of active ingredient is Propineb and Metalaxyl-M compound disinfectant.
Background technology
Propineb is a kind of rich zinc broad spectrum protection bactericide; bactericidal range is wide; repeatedly use and also can suppress causing harm of mite class and scale insect; efficient zinc supplementation; safety is good, can be in florescence medication, and also harmless to honeybee; in vegetables produce, promoted the use of positive effect, the diseases such as the downy mildew of the various crops such as morning, late blight to vegetables, tobacco, hop downy mildew and tomato and potato, early blight, late blight, downy mildew epidemic disease all have good protective effect.Propineb is applicable to tomato, Chinese cabbage, cucumber, mango and flowers and other crops.Be mainly used in preventing and treating early late blight, mango anthracnose of Chinese cabbage downy mildew, cucumber downy mildew, tomato, under recommended dose to crop safety.
Metalaxyl-M is phenylamide systemic fungicide, it is the active isomer of metalaxyl, also be the bactericide with three-dimensional optically active of first listing, disease is had to treatment and eradicant action, especially to Pseudoperonospora cubensis, phytophthora root rot bacterium, the disease such as the downy mildew of the various crops such as vegetables due to rotten mildew fungus, fruit tree, tobacco, oil plant, cotton, grain, early blight, late blight, downy mildew epidemic disease has good control efficiency.
Bactericide single dose kind often exists control efficiency poor aspect control germ, and bactericidal range is narrow, and the large germ of dispenser dosage easily develops immunity to drugs, many poisoning, the weighting ring environment pollutions etc. of easily producing of application times.For the germ that produces resistance on control crops, release and the new medicament of existing kind without cross resistance by research and development.But generally exist development cost high, the construction cycle is long, and does not catch up with germ and produce the speed of resistance.Other way, such as crop allocation adjustment, different agricultural chemicals rotations etc., has significant limitation in the process of practical operation, and effect is limited.
A certain proportion of composite by the bactericide of heterogeneity is carried out, be to prevent and treat the modal method of resistance germ.The advantage that the relative single product of sterilization pesticide compounded technology uses mainly contains: protectant, with therapeutic agent, can delay the drug-fast generation of germ; Widen pesticide control spectrum, every kind of agricultural chemicals can be prevented and treated one or more harmful germs, scope that can expanding prevention after composite; There is synergistic effect, can reduce toxicity, poisoning or residual while use, extend lasting period and next administration time, alleviate the pollution to environment; Save dosing, reduce cost accounting etc.
Summary of the invention
The present invention aims to provide good drug efficacy, the long compound disinfectant of lasting period that a kind of active ingredient is Propineb and Metalaxyl-M.Another object of the present invention is to contain the complex composition of Propineb and Metalaxyl-M, is equipped with suitable auxiliary agent and makes the bactericide of multiple formulation, makes its bactericidal range wider, control strong drug action, and holding effect is long period, and resistance risk is little.
Technical solution of the present invention is: a kind of composite bactericide, comprises Propineb and Metalaxyl-M.
Optimize, Propineb content is 15-75%, and Metalaxyl-M content is 2-30%.
Optimize, Propineb content is 50%, and Metalaxyl-M content is 6%.
All the other are in agricultural chemicals, to allow to use and acceptable auxiliary element.Optimize, the formulation of described composite bactericide is wetting powder, suspending agent, water dispersion granule.Optimize the purposes of described compound disinfectant: the application aspect the diseases such as its downy mildew control flowers downy mildew, Chinese cabbage downy mildew, cucumber downy mildew, tomato late blight morning and various crops, early blight, late blight, downy mildew epidemic disease.
Above-mentioned active ingredient Propineb and Metalaxyl-M are all bactericide well known in the art, can buy by various commercial channel.Except above-mentioned active ingredient Propineb and Metalaxyl-M, in wetting powder that described microbicide compositions is mixed with, water dispersion granule, suspending agent, also comprise carrier and auxiliary agent.Material described above is all to well known to a person skilled in the art material, can buy by market.
Beneficial effect: beneficial effect of the present invention is: 1, the bactericidal composition synergistic effect of Propineb and the compound formation of Metalaxyl-M is obvious, is not the simple superposition of each composition activity, but has significant synergistic effect; 2, the field consumption of active ingredient declines, and has reduced production and use cost, reduces residue of pesticide and environmental pollution; 3, bactericidal composition is made up of the active ingredient of different mechanism of action, is conducive to overcome and delays the drug-fast generation of germ, significant to crop safety and integrated control crop germ; 4, Propineb and Metalaxyl-M compound after, expanded fungicidal spectrum, medicament characteristic has obtained mutual supplement with each other's advantages, can prevent and treat various crop disease, facilitates peasant's medication.
Embodiment
Illustrate the present invention below in conjunction with embodiment.In embodiment, percentage is all weight percentage, and the treatment dosage of field efficacy is effective ingredient consumption.
1, wetting powder
Preparation method: in Example formulations ratio, active ingredient Propineb and Metalaxyl-M are added in carrier, and add surfactant therein, mix, mix and make wetting powder again after air-flow crushing.
2, suspending agent
Preparation method: press formula rate, active ingredient Propineb and Metalaxyl-M, surfactant and other functional aid are placed in to batching kettle successively, add water and mix, through high speed shear, wet method sand milling, last homogeneous filtration obtains product.
Physical data: use embodiment medicament 56% Propineb below. Metalaxyl-M wettable powder, 45% Propineb. Metalaxyl-M suspending agent and contrast agents 70% Wettable propineb powder and 64% Metalaxyl-M. mancozeb water dispersion granule carries out field control effectiveness test to flowers downy mildew, so that beneficial effect of the present invention to be described better, result of the test is as shown in table 1 below.
Experimental field be positioned at Linyi City Yinan County, facility plastic greenhouse flowers ground, falls ill, test first 7 days and process of the test in do not use other agricultural chemicals.Experimental field soil property is sandy loam, and rich water is medium, and management is consistent, has irrigation conditions, within general 5 days, pours water once.Duration of test temperature is at 22～35 degrees Celsius, 25 degrees Celsius of mean temperatures, air humidity 70%～90%; In this field trial, establish embodiment medicament, contrast agents and do not use totally 9 processing of any medicament, be respectively: 56% Propineb. 500 times of liquid of Metalaxyl-M wettable powder; 56% Propineb. 700 times of liquid of Metalaxyl-M wettable powder; 56% Propineb. 900 times of liquid of Metalaxyl-M wettable powder; 45% Propineb. 500 times of liquid of Metalaxyl-M suspending agent; 45% Propineb. 700 times of liquid of Metalaxyl-M suspending agent; 45% Propineb. 900 times of liquid of Metalaxyl-M suspending agent; 64% Metalaxyl-M. 700 times of liquid of mancozeb water dispersion granule; 70% 500 times of Wettable propineb powders liquid; Clear water (CK).Each processing repeats 4 times, processes communities for totally 36, and isolation strain, is OK established in minizone.Every processing community takes medicament according to the listed medicament of table 1 and the amount of taking thereof, then be watered, select the basically identical field of growing way and morbidity in the 1st medication of flowers downy mildew beginning Sheng phase, after this every 7d medication 1 time, continuous 3 times, use knapsack sprayer, amount of liquid medicine 25kg/ mu, flowers leave dual sides is subject to medicine even, avoids liquid drift, departs from target.After dispenser, medicine is for the second time executed at interval after 7 days for the first time, then after 7 days, executes medicine for the third time, altogether dispenser three times.The blade that the unified investigation of the 7th afternoon is taken after each dispenser and stem scab number, lesion area, calculate disease index, control efficiency.4 points are evenly fixed in Cha Shimei community, every 5 strains, totally 20 strains.5 leaves in every strain location,, upwards look into 5 leaves by from plant bottom the 3rd.
Drug effect standard: scab grade scale is with reference to State Standard of the People's Republic of China " pesticide field efficacy medicine test criterion ".Blade occurring degree is divided into 5 grades, flowers downy mildew leaf Seriousness gradation standard: 0 grade, blade is without scab; 1 grade, scab accounts for below 5% of full leaf area; 3 grades, scab accounts for 6%～10% of full leaf area; 5 grades, scab accounts for 11%～25% of full leaf area; 7 grades, scab accounts for 26%～50% of full leaf area; 9 grades, scab accounts for the more than 50% of full leaf area.Disease refers to calculate as follows with control efficiency:
Experimental result: in table 1
The control efficiency of table 1 different disposal to the bacillary downy mildew of flowers
Conclusive table 1 result of the test can draw, after three dispensers, embodiment medicament 56% Propineb. Metalaxyl-M wettable powder, 45% Propineb. Metalaxyl-M suspending agent to the control efficiency of the bacillary downy mildew of flowers all more than 80%, apparently higher than contrast agents, 3 various dose of embodiment medicament are processed the control efficiency of flowers downy mildew along with the increase of spraying times is in rising trend.Embodiment medicament using dosage is low in addition, compare the less dosage of contrast agents and just can reach good control efficiency, and medicament efficiency time is long.Experimental session is observed, and embodiment medicament is to flowers without poisoning, and safety is good.The above results shows to have significant synergies by Propineb and Metalaxyl-M compound disinfectant.
Biologicall test example: the composite Toxicity Determination to Pseudoperonospora cubensis of Propineb and Metalaxyl-M
Subjects: the Pseudoperonospora cubensis separating from flowers branches and leaves scab
Test method: spore germination method.Separate Pseudoperonospora cubensis from the scab of flowers branches and leaves, by germ on PDA (potato dextrose agar) medium in 25 ℃ of incubators continuous culture carry out purifying 4 times, and then be connected in PDB (potato glucose meat soup) liquid nutrient medium and cultivate spore.Cultured Pseudoperonospora cubensis spore is removed by filter to mycelia, be then mixed with the suspension of 4 × 128 spore/milliliters with sterile water.Reagent agent is diluted to corresponding concentration, and adds 3mL mixture with the spore suspension of Pseudoperonospora cubensis with 3mL, add 3mL spore suspension as blank take 3mL sterile water.Be placed in 24 ℃ of incubators and cultivate, microscopy spore germination rate after 20h, and calculate spore germination relative inhibition.12 visuals field of the random microscopy of every processing, repeat 3 times, and every spore germ tube length exceedes 1/2 of spore length and is germinating.
Spore germination relative inhibition is converted into probability value (y), liquor strength (μ g/m1) converts logarithm value (x) to, calculate concentration EC50 in virulence equation and inhibition with method of least squares, calculate toxicity index and the co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun.
Toxicity test the results are shown in Table 1.Actual measurement toxicity index (AT I)=(standard medicament EC50/ is for reagent EC50) × 100.
The percentage composition of B in percentage composition+B medicament toxicity index × mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture.
Co-toxicity coefficient (CTC)=[the theoretical toxicity index of mixture actual measurement toxicity index (ATI)/mixture (TTI)] × 100.CTC≤80, composition performance is antagonism; 80 < CTC < 120, composition performance is summation action; CTC >=120, composition performance is synergistic effect.
Measurement result (table 2) shows, the consumption of Propineb and Metalaxyl-M in the time of 15-75% and 2-30% scope, has synergistic effect to Pseudoperonospora cubensis respectively, and especially, between 5: 1～2: 20, synergistic effect is obvious, and co-toxicity coefficient is more than 170.
Experimental result: in table 2
Table 2 toxicity test result
Embodiment 1:(56% Propineb Metalaxyl-M wetting powder)
Formula: Propineb 50%; Metalaxyl-M 6%; Wetting agent neopelex 4%; Dispersant alkylphenol polyoxyethylene 10%; Filler diatomite 12%, filler bentonite surplus.
Embodiment 2:(45% Propineb. Metalaxyl-M suspending agent)
Formula: Propineb 40%; Metalaxyl-M 5%; Emulsifier neopelex 3%; Dispersant naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%; Thickener is selected gelatin and sodium carboxymethylcellulose, and consumption is respectively 0.5% and 1%; Antifreezing agent propane diols 4%; Defoamer silicone oil 0.6%; Water surplus.
Claims (5)
1. a Propineb Metalaxyl-M combination sterilization composition, is characterized in that by Propineb and Metalaxyl-M is composite forms.
2. a kind of Propineb Metalaxyl-M combination sterilization composition as claimed in claim 1, is characterized in that Propineb content is 15-75%, and Metalaxyl-M content is 2-30%.
3. a kind of Propineb Metalaxyl-M combination sterilization composition as claimed in claim 1, is characterized in that Propineb content is 50%, and Metalaxyl-M content is 6%.
4. a kind of Propineb Metalaxyl-M combination sterilization composition as claimed in claim 1, the formulation that it is characterized in that described composite bactericide is wetting powder, suspending agent, water dispersion granule.
5. a kind of Propineb Metalaxyl-M compound sterilizing combination as claimed in claim 1, the purposes that it is characterized in that described composite bactericide is the early downy mildew, early blight, late blight, downy mildew epidemic disease etc. of the various crops such as late blight of control flowers downy mildew, Chinese cabbage downy mildew, cucumber downy mildew, tomato.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105475394A (en) * | 2015-12-27 | 2016-04-13 | 胡凡营 | Biological bactericide containing propineb and metalaxyl-M |
| CN110973133A (en) * | 2019-12-30 | 2020-04-10 | 江苏宝灵化工股份有限公司 | metalaxyl-M and propineb compound sterilization composition and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1252692A (en) * | 1997-04-18 | 2000-05-10 | 拜尔公司 | Fungicide active substance combination |
| CN102204550A (en) * | 2011-04-06 | 2011-10-05 | 江苏宝灵化工股份有限公司 | Sterilization composite containing metalaxyl-M and application thereof |
| EP2494867A1 (en) * | 2011-03-01 | 2012-09-05 | Bayer CropScience AG | Halogen-substituted compounds in combination with fungicides |
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2014
- 2014-03-14 CN CN201410112205.9A patent/CN103875690A/en active Pending
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| CN105475394A (en) * | 2015-12-27 | 2016-04-13 | 胡凡营 | Biological bactericide containing propineb and metalaxyl-M |
| CN110973133A (en) * | 2019-12-30 | 2020-04-10 | 江苏宝灵化工股份有限公司 | metalaxyl-M and propineb compound sterilization composition and application thereof |
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