CN103861075A - Traditional Chinese medicine for treating insomnia and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating insomnia and a preparation method thereof, wherein the traditional Chinese medicine is prepared from the following raw medicinal materials: fluoritum, salvia miltiorrhiza, pseudo-ginseng, angelica sinensis, hoopoe, ophiopogon root, concha margaritiferallsta, radices sileris, ginseng, lucid ganoderma, Chinese yam, Chinese date, acanthopanax root, lysimachia foenum-graecum, cortex cinnamomi, baked ginger, spina date seed, radix bupleuri, prepared rhizome of rehmannia, ventilago leiocarpa benth, turnip seed, rubia yunnanensis and herba leonuri. The traditional Chinese medicine has the beneficial effects of mainly removing heat from the liver, purging fire, relaxing and calming the nerves based on the conventional theory of traditional Chinese medicine of China and having the advantages of becoming effective rapidly in treating the insomnia and being clear in curative effect, high in safety, free of toxic and side effects and less in insomnia relapse possibility.

Description

Be used for the treatment of Chinese medicine of insomnia and preparation method thereof

 

Technical field

The present invention relates to come from the medicine of plant, animal or raw mineral materials, particularly a kind of Chinese medicine that is used for the treatment of insomnia and preparation method thereof.

 

Background technology

Insomnia is due to feelings will, diet internal injury, after being ill and old, innate deficiency, the causes of disease such as timidness due to deficiency of the heart, cause lack of preservation of spirit or irritability, thereby cause often can not obtaining the class disease that ortho sleep is feature.Main manifestations be the length of one's sleep, the degree of depth not enough and can not allaying tiredness, regain one's strength and energy, the lighter's difficulty falling asleep, or sleep but not soundly, sometimes sleeping and sometimes waking, or can not sleep again after waking up, heavy be insomnia all night.

Insomnia is one of common clinical card, though do not belong to critical illness, often hinders people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia, brings long-term misery to patient, even forms the dependence to the medicine of sleeping peacefully, and long-term taking is slept peacefully, medicine can cause iatrogenic disease.

Insomnia is called " unable to close the eyes ", " insomnia ", " must not crouch " in "Nei Jing", and thinks that insomnia reason mainly contains two kinds, and the one, the impact of other diseases, as cough, vomiting, abdominal distention etc., makes the people must not peacefully sleeping; The 2nd, negative and positive of qi and blood is become estranged, make people not able person sleep, as " Plain Questions condition of disease opinion " said: " people has sleeping and uneasy to some extent person, and what is also ... dirtyly injure to some extent, and essence is posted to some extent, peace, old friend can not be hanged its disease also." " Plain Questions contrary adjust opinion " also record " disorder of the stomach leading to insomnia with restlessness " and refer to " sun bright contrary must not Cong Qi road " " contrary gas must not crouch, and coarse breathing with wheeze person ", later age, doctor extended to all incoordination between the spleen and stomach, disturb, so that the uneasy person that gets into bed of sleeping all belonged to this in phlegm-damp, dyspepsia.Difficult Classic proposes " being insomnia " this name of disease the earliest, and " difficult through 46 difficulties " thinks that the pathogenesis that old man is insomnia is " vim and vigour decline, and muscle is sliding, and the road of Rong Wei is puckery, therefore day can not be smart, must not sleep also night ".Cause the reason of insomnia to have multiple, 1, feelings will hinders or unsuccessful by feelings will, depression of liver-QI, pathogenic fire derived from stagnation of liver-QI, the pathogenic fire disturbance mind, irritability and being insomnia.Or by overaction of the five emotions, flaming of heart-fire in the interior, mind disturbance and being insomnia.Or by pondering over too, damage heart spleen, painstaking effort secretly consume, mental derangement, the weary source of insufficiency of the spleen biochemistry, deficiency of nutrient QI and blood, can not support the mind, and " Lei Zheng Zhi Cai is insomnia " said: " worry impairing spleen, spleen anemia is damaged, and is insomnia year in year out." 2, eating and drinking without temperance taste are impaired, dyspepsia is stagnated, stop up hold back in, gastric qi is become estranged, yang-energy is floating more in the outer and sleeping uneasiness of sleeping, as " Zhang Shi cures lead to and crouches " cloud: " slippery and rapid pulse effectively must not the person of crouching, in have dyspepsia phlegm-fire, this be disorder of the stomach leading to insomnia with restlessness also." or by surfeit delicious food savoury, make raw expectorant heat, the disturbance mind and sleeplessness.Or by eating and drinking without temperance, taste are injured, dysfunction of the spleen in transportation, insufficiency of generating and transforming QI and blood, deficiency of heart-blood, the heart is become homeless foster and is had a sleepless night.3, after being ill, old prolonged illness blood deficiency, lose blood puerperal, old insufficiency of blood etc. cause deficiency of heart-blood, the heart is become homeless foster, irritability and being insomnia.Said as " Jing Yue's complete work is insomnia ": " naivete and the person of being insomnia, deficiency that must ying-qi also, is sought main blood, and blood deficiency is difficult to nourish heart, the mental derangement of having a guilty conscience." 4, innate deficiency, timidness due to deficiency of the heart element body excess of YIN, holds concurrently because of excess of sexual intercourse, kidney yin consumption wound, can not on give in the heart, discordance between water(the kidney)and fire(the heart), heart-fire is solely high; Or the hepatic and renal YIN deficiency, liver-yang is partially high, and it is moving that fire is contained god, failure of the heart and kindey to integrate and mind is not peaceful.As said in " Jing Yue's complete work is insomnia ": " Kidney-Yin asthenia of essence and blood, negative and positive are not handed over, and god has the ear of being discontented with one's home." also have because of timidness due to deficiency of the heart, being terrified suddenly, state of mind uneasiness, so that lie awake all night or sleep but not soundly, as said in " miscellaneous diseases source and course rhinoceros candle be insomnia drowsirness source and course ": " have heart and gallbladder to fear timid, tactile thing is easily frightened, and how ominous dream is, the fidgets due to deficiency person of being insomnia.”

Insomnia is with the deficiency length of one's sleep, Depth of sleep not and can not allaying tiredness, to regain one's strength with energy be main syndromes feature.Wherein the length of one's sleep, deficiency person can show as difficulty falling asleep, slept night and easily woke up, and after waking up, was difficult to sleep again, and severe patient is insomnia even all night.While waking up when the inadequate person of Depth of sleep often shows as night, sleep, sleep disintoxicated, or the dream of sleeping night is many.Due to the length of one's sleep and degree of depth quality not, causing can not allaying tiredness after waking up, and shows as dizziness, headache, spiritlessness and weakness, cardiopalmus, forgetful, even malaise etc.

In modern medicine, insomnia refers to fall asleep and maybe cannot keep sleep state, causes not having enough sleep.Claim again DIMS (DlMS), for a variety of causes causes that difficulty falling asleep, Depth of sleep or frequency are too short, early awakening and the length of one's sleep not enough or of poor quality etc., be a kind of commonly encountered diseases.Insomnia tends to bring great misery and psychological burden to patient, can damage other every aspects of health because of abuse insomnia drug again.Insomnia is one of common clinical disease, though do not belong to critical illness, hinders people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia, brings long-term misery to patient, even forms the dependence to the medicine of sleeping peacefully, and long-term taking is slept peacefully, medicine can cause iatrogenic disease.Some old men are because serious insomnia has to carry out hypnosis by stable class, have just become " good friend " in the course of time with stable.This phenomenon is very general in friend person in middle and old age, thinks that stable clothes a little has no relations more, and in fact, life-time service can form dependence, even addiction.Go down because old people's hepatic and renal function weakens with the increase at age, the sleeping pill of helping yourself can cause liver and kidney failure, produces drug resistance, causes mental disorder, brings out Other diseases.Sleeping pill is in vivo mostly through liver, renal metabolism, long-term taking can increase the burden of Liver and kidney, have also can cause liver enlargement, hepatalgia, jaundice, edema, albuminuria, hematuria and feel sick, hepatic and renal function injure and the intestines and stomach reaction such as abdominal distention, inappetence, constipation.Some sleeping pill also can cause lassitude, the hypophrenia, and the accumulate poisoning symptoms such as blood pressure drops even cause respiratory and circulatory function obstacle situation.Therefore, old people applies stable more care should be used to of class medicine.

 

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of processing technology easy, and toxic and side effects is little, with low cost, take purging liver-fire, tranquilizing mind as the main Chinese medicine of insomnia and preparation method thereof that is used for the treatment of.

In order to realize foregoing invention object, the invention provides a kind of Chinese medicine that is used for the treatment of insomnia, described Chinese medicine comprises following raw medicinal material: Fluoritum, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, hoopoe, Radix Ophiopogonis, Concha Margaritifera, Radix Saposhnikoviae, Radix Ginseng, Ganoderma, Rhizoma Dioscoreae, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Herba Lysimachiae foenum-graeci, Cortex Cinnamomi, Roast Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae, Radix Bupleuri, Radix Rehmanniae Preparata, Radix seu Caulis Verntilaginis Leiocarpae, Semen Brassicae Rapae, Radix Rubiae Yunnanensis and Herba Leonuri.

In described Chinese medicine, the parts by weight of each raw medicinal material are: Fluoritum 12-23 weight portion, Radix Salviae Miltiorrhizae 12-34 weight portion, Radix Notoginseng 12-30 weight portion, Radix Angelicae Sinensis 12-30 weight portion, hoopoe 12-27 weight portion, Radix Ophiopogonis 15-30 weight portion, Concha Margaritifera 15-30 weight portion, Radix Saposhnikoviae 12-28 weight portion, Radix Ginseng 12-27 weight portion, Ganoderma 15-37 weight portion, Rhizoma Dioscoreae 10-29 weight portion, Fructus Jujubae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 12-34 weight portion, Herba Lysimachiae foenum-graeci 12-34 weight portion, Cortex Cinnamomi 12-34 weight portion, Roast Rhizoma Zingiberis Recens 12-34 weight portion, Semen Ziziphi Spinosae 12-34 weight portion, Radix Bupleuri 10-20 weight portion, Radix Rehmanniae Preparata 12-34 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 10-31 weight portion, Semen Brassicae Rapae 10-24 weight portion, Radix Rubiae Yunnanensis 10-25 weight portion and Herba Leonuri 12-24 weight portion.

In described Chinese medicine, the parts by weight of each raw medicinal material are preferably: Fluoritum 18-20 weight portion, Radix Salviae Miltiorrhizae 15-30 weight portion, Radix Notoginseng 15-27 weight portion, Radix Angelicae Sinensis 15-28 weight portion, hoopoe 15-23 weight portion, Radix Ophiopogonis 18-27 weight portion, Concha Margaritifera 19-27 weight portion, Radix Saposhnikoviae 18-23 weight portion, Radix Ginseng 15-24 weight portion, Ganoderma 20-31 weight portion, Rhizoma Dioscoreae 15-23 weight portion, Fructus Jujubae 15-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 17-26 weight portion, Herba Lysimachiae foenum-graeci 17-29 weight portion, Cortex Cinnamomi 17-27 weight portion, Roast Rhizoma Zingiberis Recens 18-29 weight portion, Semen Ziziphi Spinosae 19-23 weight portion, Radix Bupleuri 10-15 weight portion, Radix Rehmanniae Preparata 18-28 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 15-27 weight portion, Semen Brassicae Rapae 15-20 weight portion, Radix Rubiae Yunnanensis 13-21 weight portion and Herba Leonuri 16-20 weight portion.

In described Chinese medicine, the parts by weight of each raw medicinal material can also be preferably: Fluoritum 19 weight portions, Radix Salviae Miltiorrhizae 23 weight portions, Radix Notoginseng 21 weight portions, Radix Angelicae Sinensis 21 weight portions, hoopoe 19 weight portions, Radix Ophiopogonis 23 weight portions, Concha Margaritifera 23 weight portions, Radix Saposhnikoviae 20 weight portions, Radix Ginseng 19 weight portions, Ganoderma 26 weight portions, Rhizoma Dioscoreae 19 weight portions, Fructus Jujubae 21 weight portions, Radix Et Caulis Acanthopanacis Senticosi 21 weight portions, Herba Lysimachiae foenum-graeci 23 weight portions, Cortex Cinnamomi 22 weight portions, Roast Rhizoma Zingiberis Recens 24 weight portions, Semen Ziziphi Spinosae 21 weight portions, Radix Bupleuri 12 weight portions, Radix Rehmanniae Preparata 23 weight portions, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portions, Semen Brassicae Rapae 17 weight portions, Radix Rubiae Yunnanensis 17 weight portions and Herba Leonuri 18 weight portions.

In order better to realize foregoing invention object, the invention provides a kind of preparation method of the Chinese medicine that is used for the treatment of insomnia, the dosage form of described Chinese medicine is decoction, described preparation method comprises the following steps:

Step 1: take all raw medicinal materials according to parts by weight, put into purple casserole after mixing, add water to soaking medical material upper surface 2-5cm, soak 3-10 hour;

Step 2: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 30-50 minute dosage to medicinal liquid be 100-300ml, filters, and obtains filtrate a, and medicinal residues are for subsequent use;

Step 3: the medicinal residues in step 2 are added water again, cross medicinal residues upper surface 2-3cm to water logging, soak 3-10 hour;

Step 4: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 25-35 minute dosage to medicinal liquid be 100-300ml, filters, and obtains filtrate b, and filtrate a and filtrate b are mixed.

In order better to realize foregoing invention object, the present invention also provides a kind of preparation method of the Chinese medicine that is used for the treatment of insomnia, and the dosage form of described Chinese medicine is granule, and described preparation method comprises the following steps:

Step 1: take all raw medicinal materials according to parts by weight, the ethanol that to add with respect to the determining alcohol of 4～8 times, mixture after mix homogeneously be 85%～95%, be heated to boiling reflux 3～5 hours, filter, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, the mastic that while being evaporated to 50～60 ℃ subsequently under vacuum 0.06～0.09Mpa, relative density is 1.04～1.10, spraying is dry, 160～175 ℃ of the inlet temperature of spray dryer, 80～85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.2～0.4 times of dried cream powder quality and the dextrin of 0.1～0.2 times, granulation, dry under the condition of 40～50 ℃, obtain granule.

Described Chinese medicine preferably also comprises: Radix Polygalae, Rhizoma Acori Graminei, Semen Aesculi, Cortex Albiziae and Radix Glycyrrhizae.

In described Chinese medicine, the parts by weight of each raw medicinal material are preferably: Fluoritum 12-23 weight portion, Radix Salviae Miltiorrhizae 12-34 weight portion, Radix Notoginseng 12-30 weight portion, Radix Angelicae Sinensis 12-30 weight portion, hoopoe 12-27 weight portion, Radix Ophiopogonis 15-30 weight portion, Concha Margaritifera 15-30 weight portion, Radix Saposhnikoviae 12-28 weight portion, Radix Ginseng 12-27 weight portion, Ganoderma 15-37 weight portion, Rhizoma Dioscoreae 10-29 weight portion, Fructus Jujubae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 12-34 weight portion, Herba Lysimachiae foenum-graeci 12-34 weight portion, Cortex Cinnamomi 12-34 weight portion, Roast Rhizoma Zingiberis Recens 12-34 weight portion, Semen Ziziphi Spinosae 12-34 weight portion, Radix Bupleuri 10-20 weight portion, Radix Rehmanniae Preparata 12-34 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 10-31 weight portion, Semen Brassicae Rapae 10-24 weight portion, Radix Rubiae Yunnanensis 10-25 weight portion, Herba Leonuri 12-24 weight portion, Radix Polygalae 10-20 weight portion, Rhizoma Acori Graminei 8-24 weight portion, Semen Aesculi 10-20 weight portion, Cortex Albiziae 15-25 weight portion and Radix Glycyrrhizae 15-30 weight portion.

In described Chinese medicine, the parts by weight of each raw medicinal material can also be preferably: Fluoritum 18 weight portions, Radix Salviae Miltiorrhizae 23 weight portions, Radix Notoginseng 18 weight portions, Radix Angelicae Sinensis 21 weight portions, hoopoe 17 weight portions, Radix Ophiopogonis 22 weight portions, Concha Margaritifera 19 weight portions, Radix Saposhnikoviae 21 weight portions, Radix Ginseng 18 weight portions, Ganoderma 32 weight portions, Rhizoma Dioscoreae 22 weight portions, Fructus Jujubae 21 weight portions, Radix Et Caulis Acanthopanacis Senticosi 23 weight portions, Herba Lysimachiae foenum-graeci 18 weight portions, Cortex Cinnamomi 17 weight portions, Roast Rhizoma Zingiberis Recens 19 weight portions, Semen Ziziphi Spinosae 12 weight portions, Radix Bupleuri 17 weight portions, Radix Rehmanniae Preparata 24 weight portions, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portions, Semen Brassicae Rapae 18 weight portions, Radix Rubiae Yunnanensis 18 weight portions, Herba Leonuri 18 weight portions, Radix Polygalae 14 weight portions, Rhizoma Acori Graminei 16 weight portions, Semen Aesculi 15 weight portions, Cortex Albiziae 21 weight portions and Radix Glycyrrhizae 21 weight portions.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: Chinese medicine of the present invention utilizes the traditional theory of Chinese medical science of China, take purging liver-fire, tranquilizing mind as main, that treatment of insomnia patients has is rapid-action, determined curative effect, safe, have no side effect and be difficult for the advantage of recurrence.

 

The specific embodiment

The invention provides a kind of Chinese medicine that is used for the treatment of insomnia, comprise following raw medicinal material: Fluoritum, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, hoopoe, Radix Ophiopogonis, Concha Margaritifera, Radix Saposhnikoviae, Radix Ginseng, Ganoderma, Rhizoma Dioscoreae, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Herba Lysimachiae foenum-graeci, Cortex Cinnamomi, Roast Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae, Radix Bupleuri, Radix Rehmanniae Preparata, Radix seu Caulis Verntilaginis Leiocarpae, Semen Brassicae Rapae, Radix Rubiae Yunnanensis and Herba Leonuri; Preferably, also comprise: Radix Polygalae, Rhizoma Acori Graminei, Semen Aesculi, Cortex Albiziae and Radix Glycyrrhizae.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Fluoritum: sweet, temperature.GUIXIN, lung, kidney channel.Function cures mainly: tranquilizing mind, warming the lung, warm palace.For insomnia and dreamful sleep, palpitation and being susceptible to fright, cough and asthma due to lung deficiency, infertility.

Radix Salviae Miltiorrhizae: hardship, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, the tumbling down pain of injury, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG is controlled gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, only taste Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, the stillborn fetus that falls, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.

Radix Notoginseng: warm in nature, sweet in the mouth, micro-hardship, nontoxic, return liver, stomach warp.Function: hemostasis; Loose blood; Analgesic therapy.Cure mainly: fall and flutter congestive edema, thoracic obstruction angor, lump in the abdomen; Blood stasis amenorrhea; Dysmenorrhea; The cloudy stomachache of the stasis of blood in puerperal; Sore, carbuncle and painful swelling.Health care cures mainly: blood vessel dilating, reduce blood pressure, improve microcirculation, increase blood flow, prevention and treatment heart and brain tissues ischemia, anoxia; Promote protein, ribonucleic acid (RNA), DNA (deoxyribonucleic acid) (DNA) to synthesize, building body; Promote blood cell metabolism, balance adjustment blood cell; Two-ways regulation nervus centralis, improves mentally, strengthens learning and memory ability; Enhancing human body immunity function, antitumor; Hemostasis, blood circulation promoting and blood stasis dispelling; Protect the liver, antiinflammatory; Slow down aging; Two-ways regulation blood glucose, reduction blood fat, cholesterol, inhibition arteriosclerosis.In addition, Radix Notoginseng has anti-liver injury effect, PNS(arasaponin) can significantly reduce CCl4 hepatic injury mice serum ALT activity.The Liver Damage in Rats that methanolic extract causes CCl4, D mono-galactosamine, can significantly reduce AST and lactic acid dehydrogenase (LDH) activity in rat blood serum, and hepatocellular degeneration necrosis is alleviated.Radix Notoginseng also has effect of anti hepatic fibrosis, to the hepatic injury of N-nitrosodimethylamine poisoning rat, treats 4 weeks with Radix Notoginseng powder, and hepatocellular degeneration necrosis is alleviated, and between hepatocyte, collagen fiber reduce.To the poisoning hepatic fibrosis rats of CCl4, in giving CCl4 moulding, oral Radix Notoginseng powder is prevented and treated 9 weeks, can alleviate liver fat degeneration, inflammatory cell infiltration, hepatocellular degeneration necrosis.Be reduced to the hypertrophy of fibrocyte and collagen.Radix Notoginseng has certain choleretic effect, and the Rabbit Liver internal congestion jaundice that Radix Notoginseng injection causes a-α-naphthyl isothiocyanate has remarkable reduction serum bilirubin, promotes bile secretion effect.Radix Notoginseng promotes hepatic protein synthetic, increases the mix speed of 3H-TdR to impaired liver dna, increases the mix speed of 3H-leucine to hepatic protein.

Radix Angelicae Sinensis: sweet in the mouth, pungent, bitter, warm in nature, return liver, the heart, spleen channel, hematonic, emmenagogue, analgesic, the effect of enriching blood and invigorating blood circulation, cures mainly all cards of blood deficiency, ulcer sores.For oral administration: to decoct soup, 6-12 gram; Or enter ball, loose; Or infusing drugs in wine; Or deposited cream.1. first Wang Haogu Materia Medica of Decoction of writing: Radix Angelicae Sinensis, few the moon of starting with, with the main blood of its heart also; Enter foot lunar, wrap up in blood also with its spleen; Enter the sufficient the moon of fainting, with its blood stored in the liver also.Head can removing blood stasis, and body can nourish blood, the promoting the circulation of blood of tail energy, user regardless of, not as not making.If use entirely, all can enrich blood at ginseng, stilbene; Leading a cow, Radix Et Rhizoma Rhei, all can removing blood stasis, assistant makes fixed point, user is when knowing.From osmanthus, heat of attached, the Fructus Evodiae; Cold from Radix Et Rhizoma Rhei, Natrii Sulfas.Only wine Radix Angelicae Sinensis (steamed), controls again headache, with its all headache all belong to wood, therefore with blood medicine master it.2. bright Ni Zhumo writes by " book on Chinese herbal medicine converge with speech ": all sick nights very person, disorders of blood also, should be used it, all sick cold caused by deficiency persons, YANG unable to attach to somewhere also, should be used it.Pyrexial malaria cold and heat, not intramuscular outside skin, and washing in skin, sees among husband's skin, the institute of ying-qi can be also, pyrexial malaria is prolonged for a long time, empty in ying-qi, cold and heat are handed over and are striven, sweating is washed, with blood health preserving with drugs battalion, battalion and and with defend tune, how seek and defend and adjust, can not stopping of pyrexial malaria.3. Sheng Nong's herbal classic ": sweet in the mouth, temperature.Main cough with dyspnea, pyrexial malaria, cold and heat, wash in skin (" grand sight this " washes sound tinea), married woman's sterilization that leaks down, all evil wound infectionss, gold wound.Boil drink.

Hoopoe: function cures mainly: softening liver for calming endogenous wind, tranquilizing mind.

Radix Ophiopogonis: sweet; Micro-hardship; Cold.Cure mainly: nourishing YIN and moistening the lung; Reinforcing stomach reg fluid; Relieving restlessness clears away heart-fire.Dryness of the lung dry cough, spits blood, spitting of blood, and consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, quenches one's thirst, calentura Tianjin wound, dry mouth and throat, constipation." book on Chinese herbal medicine converges and says ": Radix Ophiopogonis, the medicine of clearing away heart-fire and moistening the lung also.Main deficiency of heart-QI, palpitation with fear palpitation with a distress feeling, forgetful in a trance, spirit fall; Or the lung-heat dryness of the lung, cough sound running fire, consumptive lung disease leaf scorch, the dyspnea due to deficiency of losing heart, in fire volt lung, spitting of blood hemoptysis; Or asthenia exopathogenic heat, body fluid is dry few; Or taste are dry dries up, constipation due to insufficiency dyschezia; All the strongly fragrant card of cardiopulmonary kidney spleen unit asthenic fire is also for this.But sweet in the mouth gas is flat, energy lung benefiting gold, bitter in the mouth is cold in nature, can fall heart-fire, and body profit matter is mended, and can support medulla renis, and the merit of specially controlling strain deficiency-heat is in the majority.Stagnation of QI in chest and abdomen as main in front Gu, damaging the spleen and stomach wound is full, and stomach channels is exhausted, and the weakness and emaciation disease such as lose heart, belongs to strain bright." book on Chinese herbal medicine newly organized ": Radix Ophiopogonis, the volt fire in eliminating the pathogens from the lung, the pathogenic heat in clearing stomach, the impairment caused by overstrain of reinforcing the heart gas, the vomiting of hemostasis man, beneficial smart reinforcing YIN-essence, separates tired quenching the thirst, U.S. color, happy skin, reducing the asthenic fever, separates the dryness of the lung, fixed cough, what very can hold is monarch and making also for minister of can borrowing.But the magical effect of common people unknown Radix Ophiopogonis, often use less and can not be successfully for unfortunately also.Do not know that Radix Ophiopogonis is necessary multiplex, strength begins large, and Gai Huofu, in lung, sparkles dry interior liquid, and more than Radix Ophiopogonis, fire can not be made; Heat is vehement in stomach, endures its moon to the greatest extent, and more than Radix Ophiopogonis, fire can not cease.More have the fire of bladder, superinverse is in ambition, and urine drop can not go out, and people thinks that urine fire closes, due to the heat of bladder also, do not imitate with the medicine of water flowing, do not imitate with the agent of pathogenic fire reducing, how does this use again? the gas of lid bladder, must the clear respectful order of the part of the body cavity above the diaphragm housing the heart and lungs go, and fire is to decline, and water is lower logical.The clear respectful order of husband's part of the body cavity above the diaphragm housing the heart and lungs is reported in lung also, heat of the lung, and making that lung is respectful is clearly not all right, and bladder fire closes, water also closes.Therefore wish is led to bladder person, gas that must lung heat clearing gold, the medicine of lung heat clearing is a lot of, all damages unhelpfully, if do not have benefit in clear Radix Ophiopogonis eventually, can rush down the fire of bladder, and don't damage the gas of bladder, but use less it, also can not be successful, lid abnormal smells from the patient Radix Ophiopogonis is flat cold, must be multiplex and begin have Ji also.

Concha Margaritifera: salty, cold.Return liver, heart channel.Function cures mainly: suppressing the hyperactive liver and subsiding YANG, arresting convulsion improving eyesight.Be used for having a headache dizzy, irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision.

Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature.Return bladder, liver, spleen channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.Cure mainly diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.For headache due to common cold, rubella pruritus.Control exterior syndrome due to wind-cold, headache general pain, aversion to wind and cold person, Chang Peiwu Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis etc.; Control diseases caused by exogenous pathogenic factor rheumatism, headache as wrap up in, heavy sensation of the body acroesthesia person, be equal to use with Rhizoma Et Radix Notopterygii, Rhizoma Ligustici; Control rubella pruritus, polygamy 5 Radix Sophorae Flavescentiss, Herba Schizonepetae, Radix Angelicae Sinensis etc.

Radix Ginseng: sweet, micro-hardship, flat.Return spleen, lung, heart channel.Function cures mainly: strongly invigorating primordial QI, and multiple arteries and veins is admittedly de-, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.

Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, and respiratory system is had to phlegm-dispelling functions, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.

Rhizoma Dioscoreae: sweet in the mouth, property are put down, and enter lung, spleen, kidney channel; Not dry oiliness, there are strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, grow that will is calmed the nerves, effect of life lengthening; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red disease such as swollen, fat of the frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.Compendium of Material Medica is summarized five large functions " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, the saliva that reduces phlegm, profit skin ".Rhizoma Dioscoreae is cooked congee or simmers after ripe and take with crystal sugar, and, colitis poor to health, deficiency of the kidney chronic diseases are all effective in cure.Strengthen the spleen and stomach: treatment weakness of the spleen and stomach, have loose bowels, body is tired, lack of appetite, sweating due to debility.Lung benefiting nourishing kidney: this product is cold not dry, sweet in the mouth matter profit, can treat lung suffer from a deficiency of the kidney damage quench one's thirst, pass out semen, be with inferior disease.Be described as angle's medicine.

Fructus Jujubae: there is immunosuppressive action, the ethanol extract of Fructus Jujubae with every day 100mg to rat oral gavage, show Fructus Jujubae there is same immunosuppressant with azathioprine; Can suppress the generation of antibody to atopic diseases.Fructus Jujubae ethanol extract may have inhibitory action to rat reactive antibody, and non-reacted antibody is not produced to other effects of inhibitory action: the two glucoside A of flavone in Fructus Jujubae, pharmacological evaluation proves to have calmness, hypnosis and hypotensive effect, Fructus Jujubae to have the effect that increases cAMP in leukocyte.Fructus Jujubae decoct can reduce the damage of CCl4 to Rabbit Liver.Can extend the swimming time of mice.Report Fructus Jujubae has the proliferation function of anticancer recently.

Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, micro-hardship, slightly warm in nature.Return spleen, kidney, heart channel.Modern medicine studies have shown that effect feature and the Radix Ginseng of Radix Et Caulis Acanthopanacis Senticosi is basic identical, has the disorder of the body of adjusting, makes it to be tending towards normal function.There is good antifatigue effect, remarkable compared with Radix Ginseng, and can significantly improve hypoxia-bearing capability.The functions such as invigorating middle warmer, benefit essence, strong will, wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt, stomach invigorating diuresis.Clothes " make light of one's life by commiting suicide and endure hardships " for a long time.Radix Et Caulis Acanthopanacis Senticosi contains noticeable composition---eleutheroside, and it can stimulate mind & body vigor.Numerous scientific publications about Radix Et Caulis Acanthopanacis Senticosi have proved its antifatigue effect, strengthen endurance and ability, increase alertness and learning capacity.Numerous usages have all obtained confirmation in human experimentation.Radix Et Caulis Acanthopanacis Senticosi is rehabilitation after being ill, bears too much pressure or anxiety, works excessive, and chronic disease causes weakly crowd and those need to reach very welcome self-medication medicine in the people on physiology and psychological performance peak.At present there is equally the report of considerable quantity to point out that it has support immune system, recover improper hypotension, improve blood circulation, make disorderly glycolipid metabolism normalization, liver, testis, anabolic effect of bone density and other vitals.Radix Et Caulis Acanthopanacis Senticosi extract shows can irritation cell immunity.Research finds that it can stimulate T-cell to produce, particularly assistant's cell.Therefore Radix Et Caulis Acanthopanacis Senticosi is used to panimmunity relevant disease.Radix Et Caulis Acanthopanacis Senticosi polysaccharide also has strong inhibitory action to the in-vitro multiplication of mice S180, human leukaemia K562 cell, and Radix Et Caulis Acanthopanacis Senticosi extract is containing multiple glycoside and Radix Et Caulis Acanthopanacis Senticosi polysaccharide, have improve immunity of organisms, leukocyte increasing, raising body to anoxia, radiation, stress, the adaptive capacity of the non-specific injury such as tired, poisoning.Tumor is had to obvious inhibitory action, also can promote marrow hemopoietic stem cells to the differentiation of grain-mononuclear cell, leukocyte to be increased simultaneously.

Herba Lysimachiae foenum-graeci: sweet, light, flat.Function cures mainly: heat clearing away, and circulation of qi promoting, pain relieving, drives ascarid.For headache due to common cold, toothache, laryngopharynx swelling and pain, fullness in the chest abdominal distention, ascariasis.

Cortex Cinnamomi: pungent, sweet, hot greatly.Return kidney, spleen, the heart, Liver Channel.Function cures mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, and conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.

Roast Rhizoma Zingiberis Recens: pungent, temperature.Function cures mainly: and middle preventing or arresting vomiting.Be applicable to the disease such as incoordination between the spleen and stomach, nausea and vomiting.

Semen Ziziphi Spinosae: sweet, sour, flat.Return liver, gallbladder, heart channel.Function cures mainly: tonifying liver, and mind calming, arresting sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.

Radix Bupleuri: clearind deficient heat Chinese medicine, for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus come off, menoxenia.Radix Bupleuri begins to be loaded in Shennong's Herbal, classifies as top grade.Promote immunity function, effective ingredient: Bupleurum chinense polysaccharide.Effect: phagocytic function strengthens, Natural killer activity strengthens, and improves special viral antibody titre, improves lymphocyte and turns core rate, improves skin delayed hypersensitivity reaction.Anti-liver injury, injection of Radix Bupleuri (concentration 1: a 1) 1 ml/ subcutaneous injection can significantly reduce the rat blood serum GPT rising that carbon tetrachloride causes for continuous 5 days, hepatocellular degeneration and necrosis also obviously alleviate, and in hepatocyte, glycogen and rna content also approach normal.

Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.The yin nourishing of enriching blood, life essence-filling, marrow-benefitting." Bencao Congxin ": " kidney nourishing water, packing bone marrow, sharp blood vessels, tonification is Kidney-Yin, hearing-improing and eyesight improving, hair color crow palpus.Again can tonifying spleen-yin, only chronic diarrhea.Control impairment caused by overstrain migratory arthralgia, cloudy losing generated heat, dry cough phlegmatic cough, and dyspnea with shortness of breath, it is hungry that emptiness of the stomach is felt, and pox is demonstrate,proved the no pus of having a guilty conscience, and shin thigh is ached after being ill, and the anxious pain of umbilicus abdomen in puerperal, feels card the moon and loses, lossless constipation, all kinds of moving blood, all hepatic and renal YIN deficiency, deficient all kinds of diseases and ailments, are strengthening renal yin to inhibit predominant yang medicine.”

Radix seu Caulis Verntilaginis Leiocarpae: sweet, temperature.Function cures mainly: benefiting vital QI and blood, dispelling, collateral-activating.Control deficiency of both QI and blood, rheumatalgia, traumatic injury.

Semen Brassicae Rapae: pungent, flat.Enter liver, spleen two warps.Function cures mainly: improving eyesight, heat clearing away, dampness removing.Control optic atrohic blindness, order is dark, jaundice, dysentery, dysuria.

Radix Rubiae Yunnanensis: bitter, sweet, temperature.Function cures mainly: regulating menstruation and activating blood, promoting tissue regeneration by removing blood stasis.For menoxenia, dysmenorrhea, blood deficiency amenorrhea, lumbago due to renal deficiency.

Herba Leonuri: enter the heart, liver, urinary bladder channel.Effect: promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing.Treatment edema, dysuria.The treatment water stasis of blood is tied mutually, congestion obstacle bladder.Can treat sore and toxic, urticaria.Promoting blood flow to regulate menstruation, for amenorrhea due to stagnation of blood, dysmenorrhea, blockage of menstruation, prolonged lochia, the stagnant stomachache of the stasis of blood.Can be used for again traumatic injury.Effect to uterus: Herba Leonuri decoct, ethanol extract and leonurine have excitation to the isolated uterine of the many animals such as rabbit, cat.To cardiovascular effect: Herba Leonuri is dirty to guinea-pig heart, cause myocardial infarction and ischemia model with isoproterenol, can significantly increase coronary flow and decreased heart rate quite significantly. quiet note motherwort formulation makes anesthetized dog obviously increase coronary flow, reduce coronary resistance, the effect of decreased heart rate and minimizing output and left ventricular work.Antiplatelet aggregation and antithrombotic form: in vitro tests proves, Herba Leonuri and extract thereof have intact animal's platelet aggregation of antagonism ADP induction. and in vivo test also proves that Herba Leonuri can significantly reduce total number of blood platelet and the interior platelet of alveolar wall blood capillary and the aggregation thereof in peripheral circulation. and Herba Leonuri has remarkable dissolution to rabbit pulmonary circulation red thrombus. and in addition, Herba Leonuri also has the effects such as the cellular immunization of enhancing body.Other effect: Herba Leonuri alkalescence subcutaneous injection has central inhibitory action, and MLD is 0.4-0.6g/kg.Intravenous rabbit injection leonurine 1mg/kg, visible urine amount significantly increases.Leonurine can make Sanguis Leporis seu oryctolagi suspension generation haemolysis in the time of higher concentration.Leonurine infusion tube dilution method 1:13-1:10, to achorion schoenleinii, Pilus Caprae seu Ovis sample sporidiole bacteria, epidermophyton rubrum, starlike nocadia all have inhibitory action.The dull and stereotyped paper disk method of Herba Leonuri decoct, has inhibitory action to escherichia coli, dysentery bacterium.

Radix Polygalae:

Rhizoma Acori Graminei: pungent, bitter, temperature.GUIXIN, stomach warp.Function cures mainly: removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.

Semen Aesculi: sweet, temperature.Return liver, stomach warp.Function cures mainly: regulating the flow of QI to ease the stomach, and stomach and alleviating pain.Vexed for breast abdominal distention, gastralgia.

Cortex Albiziae: sweet, flat.GUIXIN, liver, lung meridian.Function cures mainly: resolving stagnation for tranquilization, promoting blood circulation and detumescence.For irritability, melancholy insomnia, lung abscess skin ulcer is swollen, falls and flutters the pain of injury.

Radix Glycyrrhizae: sweet in the mouth, property is flat, nontoxic, enters spleen, stomach, lung meridian." pearl sac " recorded: raw sweet, flat; Process sweet, temperature.Function cures mainly: treating disorders in five ZANG-organs six internal organs cold and heat pathogen, and hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Raw pathogenic fire purging heat, the ripe use exterior cold of fall apart of use, goes pharyngalgia, removes pathogenic heat, delays healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.Emergency removing toxic substances, mediation hundred medicines." herbal classic " records it: main the five internal organs six mansion cold and heat pathogens, and hard muscles and bones, longue meat, times power, incised wound is swollen, removing toxic substances.Medication taboo: the wet distension of containing, edema person should not use.Can not be with Cyprinus carpio with food, with eating, meeting is poisoning.The anti-Radix Euphorbiae Pekinensis, Flos Genkwa, Radix Kansui, Sargassum.Take for a long time the Radix Glycyrrhizae of larger dose, can cause edema etc.Collective Notes to the Canon of Materia medica is recorded: " art, Resina Toxicodendri, Radix Sophorae Flavescentis make for it.Dislike Radix Polygalae.The anti-Radix Euphorbiae Pekinensis, Flos Genkwa, Radix Kansui, Sargassum four things ".

 

In described Chinese medicine, the parts by weight of each raw medicinal material are: Fluoritum 12-23 weight portion, Radix Salviae Miltiorrhizae 12-34 weight portion, Radix Notoginseng 12-30 weight portion, Radix Angelicae Sinensis 12-30 weight portion, hoopoe 12-27 weight portion, Radix Ophiopogonis 15-30 weight portion, Concha Margaritifera 15-30 weight portion, Radix Saposhnikoviae 12-28 weight portion, Radix Ginseng 12-27 weight portion, Ganoderma 15-37 weight portion, Rhizoma Dioscoreae 10-29 weight portion, Fructus Jujubae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 12-34 weight portion, Herba Lysimachiae foenum-graeci 12-34 weight portion, Cortex Cinnamomi 12-34 weight portion, Roast Rhizoma Zingiberis Recens 12-34 weight portion, Semen Ziziphi Spinosae 12-34 weight portion, Radix Bupleuri 10-20 weight portion, Radix Rehmanniae Preparata 12-34 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 10-31 weight portion, Semen Brassicae Rapae 10-24 weight portion, Radix Rubiae Yunnanensis 10-25 weight portion and Herba Leonuri 12-24 weight portion.

In described Chinese medicine, the parts by weight of each raw medicinal material are preferably: Fluoritum 18-20 weight portion, Radix Salviae Miltiorrhizae 15-30 weight portion, Radix Notoginseng 15-27 weight portion, Radix Angelicae Sinensis 15-28 weight portion, hoopoe 15-23 weight portion, Radix Ophiopogonis 18-27 weight portion, Concha Margaritifera 19-27 weight portion, Radix Saposhnikoviae 18-23 weight portion, Radix Ginseng 15-24 weight portion, Ganoderma 20-31 weight portion, Rhizoma Dioscoreae 15-23 weight portion, Fructus Jujubae 15-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 17-26 weight portion, Herba Lysimachiae foenum-graeci 17-29 weight portion, Cortex Cinnamomi 17-27 weight portion, Roast Rhizoma Zingiberis Recens 18-29 weight portion, Semen Ziziphi Spinosae 19-23 weight portion, Radix Bupleuri 10-15 weight portion, Radix Rehmanniae Preparata 18-28 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 15-27 weight portion, Semen Brassicae Rapae 15-20 weight portion, Radix Rubiae Yunnanensis 13-21 weight portion and Herba Leonuri 16-20 weight portion.

In described Chinese medicine, the parts by weight of each raw medicinal material can also be preferably: Fluoritum 19 weight portions, Radix Salviae Miltiorrhizae 23 weight portions, Radix Notoginseng 21 weight portions, Radix Angelicae Sinensis 21 weight portions, hoopoe 19 weight portions, Radix Ophiopogonis 23 weight portions, Concha Margaritifera 23 weight portions, Radix Saposhnikoviae 20 weight portions, Radix Ginseng 19 weight portions, Ganoderma 26 weight portions, Rhizoma Dioscoreae 19 weight portions, Fructus Jujubae 21 weight portions, Radix Et Caulis Acanthopanacis Senticosi 21 weight portions, Herba Lysimachiae foenum-graeci 23 weight portions, Cortex Cinnamomi 22 weight portions, Roast Rhizoma Zingiberis Recens 24 weight portions, Semen Ziziphi Spinosae 21 weight portions, Radix Bupleuri 12 weight portions, Radix Rehmanniae Preparata 23 weight portions, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portions, Semen Brassicae Rapae 17 weight portions, Radix Rubiae Yunnanensis 17 weight portions and Herba Leonuri 18 weight portions.

In described Chinese medicine, the parts by weight of each raw medicinal material are preferably: Fluoritum 12-23 weight portion, Radix Salviae Miltiorrhizae 12-34 weight portion, Radix Notoginseng 12-30 weight portion, Radix Angelicae Sinensis 12-30 weight portion, hoopoe 12-27 weight portion, Radix Ophiopogonis 15-30 weight portion, Concha Margaritifera 15-30 weight portion, Radix Saposhnikoviae 12-28 weight portion, Radix Ginseng 12-27 weight portion, Ganoderma 15-37 weight portion, Rhizoma Dioscoreae 10-29 weight portion, Fructus Jujubae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 12-34 weight portion, Herba Lysimachiae foenum-graeci 12-34 weight portion, Cortex Cinnamomi 12-34 weight portion, Roast Rhizoma Zingiberis Recens 12-34 weight portion, Semen Ziziphi Spinosae 12-34 weight portion, Radix Bupleuri 10-20 weight portion, Radix Rehmanniae Preparata 12-34 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 10-31 weight portion, Semen Brassicae Rapae 10-24 weight portion, Radix Rubiae Yunnanensis 10-25 weight portion, Herba Leonuri 12-24 weight portion, Radix Polygalae 10-20 weight portion, Rhizoma Acori Graminei 8-24 weight portion, Semen Aesculi 10-20 weight portion, Cortex Albiziae 15-25 weight portion and Radix Glycyrrhizae 15-30 weight portion.

In described Chinese medicine, the parts by weight of each raw medicinal material can also be preferably: Fluoritum 18 weight portions, Radix Salviae Miltiorrhizae 23 weight portions, Radix Notoginseng 18 weight portions, Radix Angelicae Sinensis 21 weight portions, hoopoe 17 weight portions, Radix Ophiopogonis 22 weight portions, Concha Margaritifera 19 weight portions, Radix Saposhnikoviae 21 weight portions, Radix Ginseng 18 weight portions, Ganoderma 32 weight portions, Rhizoma Dioscoreae 22 weight portions, Fructus Jujubae 21 weight portions, Radix Et Caulis Acanthopanacis Senticosi 23 weight portions, Herba Lysimachiae foenum-graeci 18 weight portions, Cortex Cinnamomi 17 weight portions, Roast Rhizoma Zingiberis Recens 19 weight portions, Semen Ziziphi Spinosae 12 weight portions, Radix Bupleuri 17 weight portions, Radix Rehmanniae Preparata 24 weight portions, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portions, Semen Brassicae Rapae 18 weight portions, Radix Rubiae Yunnanensis 18 weight portions, Herba Leonuri 18 weight portions, Radix Polygalae 14 weight portions, Rhizoma Acori Graminei 16 weight portions, Semen Aesculi 15 weight portions, Cortex Albiziae 21 weight portions and Radix Glycyrrhizae 21 weight portions.

In the time that the dosage form of Chinese medicine is decoction, described preparation method comprises the following steps:

Step 1: take all raw medicinal materials according to parts by weight, put into purple casserole after mixing, add water to soaking medical material upper surface 2-5cm, soak 3-10 hour;

Step 2: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 30-50 minute dosage to medicinal liquid be 100-300ml, filters, and obtains filtrate a, and medicinal residues are for subsequent use;

Step 3: the medicinal residues in step 2 are added water again, cross medicinal residues upper surface 2-3cm to water logging, soak 3-10 hour;

Step 4: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 25-35 minute dosage to medicinal liquid be 100-300ml, filters, and obtains filtrate b, and filtrate a and filtrate b are mixed.

In the time that the dosage form of Chinese medicine is granule, described preparation method comprises the following steps:

Step 1: take all raw medicinal materials according to parts by weight, the ethanol that to add with respect to the determining alcohol of 4～8 times, mixture after mix homogeneously be 85%～95%, be heated to boiling reflux 3～5 hours, filter, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, the mastic that while being evaporated to 50～60 ℃ subsequently under vacuum 0.06～0.09Mpa, relative density is 1.04～1.10, spraying is dry, 160～175 ℃ of the inlet temperature of spray dryer, 80～85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.2～0.4 times of dried cream powder quality and the dextrin of 0.1～0.2 times, granulation, dry under the condition of 40～50 ℃, obtain granule.

 

Embodiment 1 decoction

The embodiment of the present invention provides a kind of Chinese medicine that is used for the treatment of insomnia, in Chinese medicine, the parts by weight of each raw medicinal material are: Fluoritum 20 weight portions, Radix Salviae Miltiorrhizae 30 weight portions, Radix Notoginseng 27 weight portions, Radix Angelicae Sinensis 28 weight portions, hoopoe 15 weight portions, Radix Ophiopogonis 18 weight portions, Concha Margaritifera 19 weight portions, Radix Saposhnikoviae 18 weight portions, Radix Ginseng 24 weight portions, Ganoderma 31 weight portions, Rhizoma Dioscoreae 23 weight portions, Fructus Jujubae 25 weight portions, Radix Et Caulis Acanthopanacis Senticosi 17 weight portions, Herba Lysimachiae foenum-graeci 29 weight portions, Cortex Cinnamomi 27 weight portions, Roast Rhizoma Zingiberis Recens 29 weight portions, Semen Ziziphi Spinosae 19 weight portions, Radix Bupleuri 10 weight portions, Radix Rehmanniae Preparata 18 weight portions, Radix seu Caulis Verntilaginis Leiocarpae 27 weight portions, Semen Brassicae Rapae 15 weight portions, Radix Rubiae Yunnanensis 13 weight portions and Herba Leonuri 16 weight portions.

Its preparation method comprises the following steps:

Step 1: take all raw medicinal materials according to parts by weight, put into purple casserole after mixing, add water to soaking medical material upper surface 3cm, soak 5 hours;

Step 2: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 40 minutes dosage to medicinal liquid be 200ml, filters, and obtains filtrate a, and medicinal residues are for subsequent use;

Step 3: the medicinal residues in step 2 are added water again, cross medicinal residues upper surface 2cm to water logging, soak 4 hours;

Step 4: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 30 minutes dosage to medicinal liquid be 100ml, filters, and obtains filtrate b, and filtrate a and filtrate b are mixed.

 

Embodiment 2 granules

The embodiment of the present invention provides a kind of Chinese medicine that is used for the treatment of insomnia, in Chinese medicine, the parts by weight of each raw medicinal material are: Fluoritum 19 weight portions, Radix Salviae Miltiorrhizae 23 weight portions, Radix Notoginseng 21 weight portions, Radix Angelicae Sinensis 21 weight portions, hoopoe 19 weight portions, Radix Ophiopogonis 23 weight portions, Concha Margaritifera 23 weight portions, Radix Saposhnikoviae 20 weight portions, Radix Ginseng 19 weight portions, Ganoderma 26 weight portions, Rhizoma Dioscoreae 19 weight portions, Fructus Jujubae 21 weight portions, Radix Et Caulis Acanthopanacis Senticosi 21 weight portions, Herba Lysimachiae foenum-graeci 23 weight portions, Cortex Cinnamomi 22 weight portions, Roast Rhizoma Zingiberis Recens 24 weight portions, Semen Ziziphi Spinosae 21 weight portions, Radix Bupleuri 12 weight portions, Radix Rehmanniae Preparata 23 weight portions, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portions, Semen Brassicae Rapae 17 weight portions, Radix Rubiae Yunnanensis 17 weight portions and Herba Leonuri 18 weight portions.

Its preparation method comprises the following steps:

Step 1: take all raw medicinal materials according to parts by weight, the ethanol that to add with respect to the determining alcohol of 6 times, mixture after mix homogeneously be 85%, be heated to boiling reflux 4 hours, filter, adopt the speed slowly percolation of percolation with 1ml per minute, collect percolate, the mastic that while being evaporated to 60 ℃ subsequently under vacuum 0.07Mpa, relative density is 1.25, spraying is dry, 160 ℃ of the inlet temperature of spray dryer, 80 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.3 times of dried cream powder quality and the dextrin of 0.1 times, granulation, dry under the condition of 40 ℃, obtain granule.

 

Embodiment 3 granules

The embodiment of the present invention provides a kind of Chinese medicine that is used for the treatment of insomnia, in Chinese medicine, the parts by weight of each raw medicinal material are: Fluoritum 18 weight portions, Radix Salviae Miltiorrhizae 23 weight portions, Radix Notoginseng 18 weight portions, Radix Angelicae Sinensis 21 weight portions, hoopoe 17 weight portions, Radix Ophiopogonis 22 weight portions, Concha Margaritifera 19 weight portions, Radix Saposhnikoviae 21 weight portions, Radix Ginseng 18 weight portions, Ganoderma 32 weight portions, Rhizoma Dioscoreae 22 weight portions, Fructus Jujubae 21 weight portions, Radix Et Caulis Acanthopanacis Senticosi 23 weight portions, Herba Lysimachiae foenum-graeci 18 weight portions, Cortex Cinnamomi 17 weight portions, Roast Rhizoma Zingiberis Recens 19 weight portions, Semen Ziziphi Spinosae 12 weight portions, Radix Bupleuri 17 weight portions, Radix Rehmanniae Preparata 24 weight portions, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portions, Semen Brassicae Rapae 18 weight portions, Radix Rubiae Yunnanensis 18 weight portions, Herba Leonuri 18 weight portions, Radix Polygalae 14 weight portions, Rhizoma Acori Graminei 16 weight portions, Semen Aesculi 15 weight portions, Cortex Albiziae 21 weight portions and Radix Glycyrrhizae 21 weight portions.

Its preparation method comprises the following steps:

Step 1: take all raw medicinal materials according to parts by weight, the ethanol that to add with respect to the determining alcohol of 7 times, mixture after mix homogeneously be 90%, be heated to boiling reflux 4 hours, filter, adopt the speed slowly percolation of percolation with 2ml per minute, collect percolate, the mastic that while being evaporated to 55 ℃ subsequently under vacuum 0.07Mpa, relative density is 1.08, spraying is dry, 170 ℃ of the inlet temperature of spray dryer, 82 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.3 times of dried cream powder quality and the dextrin of 0.2 times, granulation, dry under the condition of 45 ℃, obtain granule.

 

Toxicity test

1, acute toxicity test: granule prepared by the granule of preparing take the embodiment of the present invention 2 and embodiment 2 is experimental subject, granule is dissolved in respectively in distilled water, give respectively 4 groups of white mice feedings dispensings with 140 times, 200 times, 160 times of clinical consumption per day and 220 times, observe 7; The all white mice of result are strong deposits, and its diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.

2, long term toxicity test: by the embodiment of the present invention 2 granules, to mice by 7.81,18.34 and 40.11g crude drug/kg be dissolved in water, two groups of mices are distinguished to continuous uses 12 weeks, every day 2 times, and drug withdrawal is after 4 weeks, result shows: the index such as the hair of Chinese medicine of the present invention to two groups of test mices, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is very little after Chinese medicine of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.The granule of preparing take embodiment 3 according to above-mentioned test method is experimental subject, and experimental result illustrates that toxicity is little after granule prepared by the embodiment of the present invention 3 is to mice long-term prescription equally, also there is no difference reaction, application safety after drug withdrawal.

3, toxicity test: 40 of application NIH mices, SPF level, male and female half and half, body weight 16～20g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, i.e. matched group and administration group, fasting 12 hours before experiment; Decoction prepared by embodiments of the invention 1, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.

 

Clinical trial

Case selection: fetch the 200 routine insomniacs that come from the court's patients in neurological department, male 95 examples, female's 105 examples, age 35-65 year, medical history 2 months-8 years.200 routine patients are divided into four groups at random, and every group of 50 examples, are respectively embodiment group 1-3 and matched group.

Diagnostic criteria: difficulty falling asleep, be difficult to maintain sleep, at least occur weekly 3 times and continue more than 1 month, cause the obvious worries of patient or affected daily life by sleep, there is not the makings type factor that causes above-mentioned condition.

Therapeutic Method:

Embodiment group 1: take the decoction of the embodiment of the present invention 1, dose is drunk one day, and drink every day at twice, sooner or later respectively once; Within 7 days, be a course for the treatment of, use 1-3 the course for the treatment of according to symptom variation;

Embodiment group 2: take the granule of the embodiment of the present invention 2, after meal 1 time every night, each 6g; Within 7 days, be a course for the treatment of, use 1-3 the course for the treatment of according to symptom variation;

Embodiment group 3: take the granule of the embodiment of the present invention 2, after meal 1 time every night, each 6g; Within 7 days, be a course for the treatment of, use 1-3 the course for the treatment of according to symptom variation;

Matched group: take chlormezanone sheet, clothes before sleeping, an a slice; Within 7 days, be a course for the treatment of, use 1-3 the course for the treatment of according to symptom variation;

The standard of curative effect evaluation:

Recovery from illness: transference cure, recover normal or Nighttime sleep the length of one's sleep more than 6 hours, sleep deep, hale and hearty after waking up;

Effective: remission, increase the length of one's sleep more than 3 hours, Depth of sleep increases;

Effective: symptom is improved, and increases less than the length of one's sleep 3 hours;

Invalid: symptom is as front, and after treatment, insomnia is not improved or counter increasing the weight of.

Therapeutic outcome

Referring to table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs insomnia of the present invention, show for Western medicine on therapeutic effect, there is significant progress; As can be seen from Table 2, adopt treatment by Chinese herbs insomnia of the present invention, with respect to Western medicine, treating significantly shortening on the course for the treatment of.

Each group of table 1 is treated respectively Clinical efficacy comparison example after 3 courses for the treatment of

Group	Number of cases	Cure	Effective	Effectively	Invalid	Cure and obvious effective rate	Total effective rate
								Embodiment group 1	50	22	20	8	0	（42）84.0%	100%
Embodiment group 2	50	22	21	7	0	（43）86.0%	100%
								Embodiment group 3	50	25	22	3	0	（47）94.0%	100%
Matched group	50	11	17	14	8	（28）56.0%	84.0%

Each group of table 2 is cured and effective number and time comparative example (%) after treating respectively 3 courses for the treatment of

Group	Number of cases	The 1st course for the treatment of	The 2nd course for the treatment of	The 3rd course for the treatment of
					Embodiment group 1	42	12(28.6%)	19(45.2%)	11(26.2%)
Embodiment group 2	43	14(32.6%)	19(44.2%)	10(23.2%)
					Embodiment group 3	47	16(34.0%)	25(53.2%)	6(12.8%)
Matched group	28	0(0%)	11(39.3%)	17(60.7%)

Known according to the clinical statistics in above table, that Chinese medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect; In each embodiment group 1-4 and matched group, cure and effective patient follows up a case by regular visits to half a year simultaneously, result statistics, embodiment group 1 cure and effective 42 examples in, 22 examples of healing are without recurrence, 3 routine recurrences in 20 effective routine patients, without any untoward reaction; Embodiment group 2 cure and effective 43 examples in, 22 examples of healing are without recurrence, in 21 effective routine patients, 1 example recurs, without any untoward reaction; Embodiment 3 cure and effective 47 examples all without recurring, without any untoward reaction; Matched group cure and effective 28 examples in, 11 routine patient's 5 example recurrences of healing, 17 effective routine patient's 9 example recurrences, and in therapeutic process, find that the untoward reaction that daytime is tired, dizzy or have a headache appears in some patient.

 

Model case: Liu, female, 57 years old, Symptoms was: difficulty falling asleep, be difficult to maintain sleep, at least occur weekly 4 times, continue about 1 year, the obvious mental status of patient is bad, and energy is not concentrated, and has had a strong impact on daily life.Use the medicine of the embodiment of the present invention 2 to treat, after meal 1 time every night, each 6g, 7 days is a course for the treatment of, uses continuously 3 recoveries from illness courses for the treatment of, follows up a case by regular visits to not recurrence in 1 year half.

 

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (6)

1. be used for the treatment of the Chinese medicine of insomnia, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Fluoritum, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Angelicae Sinensis, hoopoe, Radix Ophiopogonis, Concha Margaritifera, Radix Saposhnikoviae, Radix Ginseng, Ganoderma, Rhizoma Dioscoreae, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Herba Lysimachiae foenum-graeci, Cortex Cinnamomi, Roast Rhizoma Zingiberis Recens, Semen Ziziphi Spinosae, Radix Bupleuri, Radix Rehmanniae Preparata, Radix seu Caulis Verntilaginis Leiocarpae, Semen Brassicae Rapae, Radix Rubiae Yunnanensis and Herba Leonuri.

2. the Chinese medicine that is used for the treatment of insomnia according to claim 1, it is characterized in that, in described Chinese medicine, the parts by weight of each raw medicinal material are: Fluoritum 12-23 weight portion, Radix Salviae Miltiorrhizae 12-34 weight portion, Radix Notoginseng 12-30 weight portion, Radix Angelicae Sinensis 12-30 weight portion, hoopoe 12-27 weight portion, Radix Ophiopogonis 15-30 weight portion, Concha Margaritifera 15-30 weight portion, Radix Saposhnikoviae 12-28 weight portion, Radix Ginseng 12-27 weight portion, Ganoderma 15-37 weight portion, Rhizoma Dioscoreae 10-29 weight portion, Fructus Jujubae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 12-34 weight portion, Herba Lysimachiae foenum-graeci 12-34 weight portion, Cortex Cinnamomi 12-34 weight portion, Roast Rhizoma Zingiberis Recens 12-34 weight portion, Semen Ziziphi Spinosae 12-34 weight portion, Radix Bupleuri 10-20 weight portion, Radix Rehmanniae Preparata 12-34 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 10-31 weight portion, Semen Brassicae Rapae 10-24 weight portion, Radix Rubiae Yunnanensis 10-25 weight portion and Herba Leonuri 12-24 weight portion.

3. the Chinese medicine that is used for the treatment of insomnia according to claim 1 and 2, it is characterized in that, in described Chinese medicine, the parts by weight of each raw medicinal material are: Fluoritum 18-20 weight portion, Radix Salviae Miltiorrhizae 15-30 weight portion, Radix Notoginseng 15-27 weight portion, Radix Angelicae Sinensis 15-28 weight portion, hoopoe 15-23 weight portion, Radix Ophiopogonis 18-27 weight portion, Concha Margaritifera 19-27 weight portion, Radix Saposhnikoviae 18-23 weight portion, Radix Ginseng 15-24 weight portion, Ganoderma 20-31 weight portion, Rhizoma Dioscoreae 15-23 weight portion, Fructus Jujubae 15-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 17-26 weight portion, Herba Lysimachiae foenum-graeci 17-29 weight portion, Cortex Cinnamomi 17-27 weight portion, Roast Rhizoma Zingiberis Recens 18-29 weight portion, Semen Ziziphi Spinosae 19-23 weight portion, Radix Bupleuri 10-15 weight portion, Radix Rehmanniae Preparata 18-28 weight portion, Radix seu Caulis Verntilaginis Leiocarpae 15-27 weight portion, Semen Brassicae Rapae 15-20 weight portion, Radix Rubiae Yunnanensis 13-21 weight portion and Herba Leonuri 16-20 weight portion.

4. according to the Chinese medicine that is used for the treatment of insomnia described in claim 1-3 any one, it is characterized in that, in described Chinese medicine, the parts by weight of each raw medicinal material are: Fluoritum 19 weight portions, Radix Salviae Miltiorrhizae 23 weight portions, Radix Notoginseng 21 weight portions, Radix Angelicae Sinensis 21 weight portions, hoopoe 19 weight portions, Radix Ophiopogonis 23 weight portions, Concha Margaritifera 23 weight portions, Radix Saposhnikoviae 20 weight portions, Radix Ginseng 19 weight portions, Ganoderma 26 weight portions, Rhizoma Dioscoreae 19 weight portions, Fructus Jujubae 21 weight portions, Radix Et Caulis Acanthopanacis Senticosi 21 weight portions, Herba Lysimachiae foenum-graeci 23 weight portions, Cortex Cinnamomi 22 weight portions, Roast Rhizoma Zingiberis Recens 24 weight portions, Semen Ziziphi Spinosae 21 weight portions, Radix Bupleuri 12 weight portions, Radix Rehmanniae Preparata 23 weight portions, Radix seu Caulis Verntilaginis Leiocarpae 21 weight portions, Semen Brassicae Rapae 17 weight portions, Radix Rubiae Yunnanensis 17 weight portions and Herba Leonuri 18 weight portions.

5. according to the preparation method of the Chinese medicine that is used for the treatment of insomnia described in claim 1-4 any one, it is characterized in that, the dosage form of described Chinese medicine is decoction, and described preparation method comprises the following steps:

Step 1: take all raw medicinal materials according to parts by weight, put into purple casserole after mixing, add water to soaking medical material upper surface 2-5cm, soak 3-10 hour;

Step 2: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 30-50 minute dosage to medicinal liquid be 100-300ml, filters, and obtains filtrate a, and medicinal residues are for subsequent use;

Step 3: the medicinal residues in step 2 are added water again, cross medicinal residues upper surface 2-3cm to water logging, soak 3-10 hour;

Step 4: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 25-35 minute dosage to medicinal liquid be 100-300ml, filters, and obtains filtrate b, and filtrate a and filtrate b are mixed.

6. according to the preparation method of the Chinese medicine that is used for the treatment of insomnia described in claim 1-4 any one, it is characterized in that, the dosage form of described Chinese medicine is granule, and described preparation method comprises the following steps:

Step 1: take all raw medicinal materials according to parts by weight, the ethanol that to add with respect to the determining alcohol of 4～8 times, mixture after mix homogeneously be 85%～95%, be heated to boiling reflux 3～5 hours, filter, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, the mastic that while being evaporated to 50～60 ℃ subsequently under vacuum 0.06～0.09Mpa, relative density is 1.04～1.10, spraying is dry, 160～175 ℃ of the inlet temperature of spray dryer, 80～85 ℃ of leaving air temps, be ground into subsequently powder, make dried cream powder;

Step 2: in the dried cream powder obtaining, add with respect to the cane sugar powder of 0.2～0.4 times of dried cream powder quality and the dextrin of 0.1～0.2 times, granulation, dry under the condition of 40～50 ℃, obtain granule.