CN103822912A - Super hydrophobic type SERS (Surface-enhanced Raman scattering) composite substrate - Google Patents
Super hydrophobic type SERS (Surface-enhanced Raman scattering) composite substrate Download PDFInfo
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- CN103822912A CN103822912A CN201310703564.7A CN201310703564A CN103822912A CN 103822912 A CN103822912 A CN 103822912A CN 201310703564 A CN201310703564 A CN 201310703564A CN 103822912 A CN103822912 A CN 103822912A
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Abstract
The invention discloses a super hydrophobic type SERS (Surface-enhanced Raman scattering) composite substrate. The composite substrate comprises a base layer with a super hydrophobic surface and an SERS substrate layer, wherein the SERS substrate layer is embedded or placed on a super hydrophobic structure surface of the substrate layer, and smaller than a solution droplet formed on the super hydrophobic surface; after the solution of detected substances drips on the SERS substrate layer, spheroidal and ellipsoidal droplets are formed on the super hydrophobic surface and can be used for fully covering the SERS substrate layer, the super hydrophobic surface and tiny SERS eliminate edge effects of the prior art, and the distribution uniformity of a detected solute on the SERS substrate layer is ensured, so that the certainty and stability of detection results are improved; the spheroidal droplets with larger specific surface areas are formed by a detected solution on the super hydrophobic surface, and the concentration of the detected solute can be increased after the spheroidal droplets are concentrated, and the detection sensitivity and accuracy can be improved, therefore, in comparison with a common SERS substrate, the substrate has better enhancement effects and ultra-high sensitivity for analysis, and is applied to detection of ultra-trace samples.
Description
Technical field
The present invention relates to Molecular Spectral Analysis detection field, be specifically related to a kind of substrate for Surface enhanced raman spectroscopy and preparation method thereof.
Background technology
Illumination is mapped to elastic scattering and inelastic scattering occurs on material, the scattered light of elastic scattering is the composition identical with excitation wavelength, inelastically scattered scattered light has the composition long and shorter than excitation light wave, is referred to as Raman scattering, and the spectrum obtaining is referred to as Raman spectrum.Raman spectrum belongs to molecular vibration spectrum, is the fingerprint of material molecule, and the Raman spectrometer of making according to Ramam effect can be for accurate qualitative discriminating sample.The analytical approach of Raman spectrum does not generally need sample to carry out pre-treatment, and easy and simple to handle in analytic process, and minute is short, is a kind of analytical technology that can simultaneously carry out to sample quantitative and qualitative analysis, has application prospect very widely.Surface enhanced raman spectroscopy (SERS) is the high sensitivity spectral analysis technique getting up based on above-mentioned principle development, and SERS can differentiate sample for accurate qualitative and quantitative, such as the content of material in solution is detected.
In prior art, SERS detects in solution generally three kinds of modes: 1. in sample solution, add nano material, and induced nano particle assembles to form SERS focus; 2. in SERS substrate, directly drip sample solution, allow it sprawl, to be dried and to analyze; 3. SERS auroral poles is inserted to sample solution collection signal etc.
In prior art, in SERS substrate, directly drip sample solution and belong to the mode comparatively generally adopting, in which, SERS substrate generally adopts the solid basic substances such as hard microslide, silicon chip, superficial growth has the material of certain roughness, then forms substrate by evaporation noble metal; Or directly on hard carrier, adhere to noble metal nanometer material, can reach good enhancing effect.The SERS substrate of above-mentioned prior art is dripping after solution, drop can spread very soon, in this process, can produce obvious edge effect, solute in ie in solution can be gathered in the marginal portion after diffusion, cause the concentration of marginal portion solute higher than center section, stability and accuracy that impact detects.Meanwhile, above-mentioned substrate does not have concentrated effect, lower to trace materials sensitivity.
Therefore, need a kind of substrate, solution is had to inspissation, guarantee the sensitivity and the accuracy that detect, the solution after concentrating avoids occurring edge effect, and the detected material content of whole concentrated solution is even, guarantee determinacy and the stability of testing result, for further promoting SERS technology at Homeland Security, environmental monitoring, the fields such as food security and health care are more widely used provides condition.
Summary of the invention
In view of this, the object of this invention is to provide a kind of high-performance and cheap super-hydrophobic type SERS composite substrate, super-drainage structure guarantees that solution drops in above as large spherical of specific surface area, be beneficial to solvent evaporates, solution is had to inspissation, guarantee the sensitive and accurate of detection, and less SERS substrate embeds in super-drainage structure or be positioned at the surface of super-hydrophobic layer, drop just can only be attached to SERS substrate, avoid solution to spread the edge effect causing, detected material is evenly distributed, guarantee determinacy and the stability of testing result, for further promoting SERS technology at Homeland Security, environmental monitoring, the field such as food security and health care is more widely used provides condition.
Super-hydrophobic type SERS composite substrate of the present invention, comprise basal layer and the SERS basalis with super hydrophobic surface, described SERS basalis embeds or is positioned over basalis super-drainage structure surface, and the size of described SERS basalis is less than a solution and is positioned at the drop size that super hydrophobic surface forms.
Further, SERS basalis is positioned over described super-drainage structure surface;
Further, described SERS basalis is formed by filter paper surface attachment surface accumulation layer;
Further, the size of described SERS basalis is the circle that diameter is less than 3 millimeters;
Further, described basal layer is arc groove shape structure, and described super hydrophobic surface is the inside surface of arc groove shape structure, and described SERS basalis is positioned at the bottommost of arc groove inside surface;
Further, surface accumulation layer is layer of precious metal, and described layer of precious metal is any one in gold, silver, copper.
Beneficial effect of the present invention: super-hydrophobic type SERS composite substrate of the present invention, the solution of detected material drips after SERS basalis, form spheroidal or elliposoidal drop and can cover this SERS basalis comprehensively on super water delivery surface, super hydrophobic surface and small SERS have eliminated the edge effect of prior art, guarantee the homogeneity that detected solute distributes in SERS substrate, thereby improved determinacy and the stability of testing result; Detected solution forms the larger spherical droplets of specific surface area at super hydrophobic surface, can improve the concentration of tested solute after it is concentrated, has improved the sensitivity and the accuracy that detect; Therefore, compare general SERS substrate, this substrate has the sensitivity for analysis of better enhancing effect and superelevation, be applicable to the detection of ultratrace sample, for further promoting SERS technology at Homeland Security, environmental monitoring, the fields such as food security and health care are more widely used provides condition.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the invention will be further described.
Fig. 1 is structural representation of the present invention;
Fig. 2 is that Fig. 1 is along A-A cut-open view.
Embodiment
Fig. 1 is structural representation of the present invention, and Fig. 2 is that Fig. 1 is along A-A cut-open view; As shown in the figure: the super-hydrophobic type SERS composite substrate of the present embodiment, comprise basal layer 1 and the SERS basalis 2 with super hydrophobic surface 11, described SERS basalis 2 embeds or is positioned over basalis 1 super-drainage structure surface 11, and the size of described SERS basalis 2 is less than a solution and is positioned at the drop size that super hydrophobic surface forms; Be that SERS basalis is schistose texture, its full-size can not be greater than a solution and drip the lateral dimension in super hydrophobic surface, solution drips and after super water delivery, forms ellipsoid or spheroidal, has covered SERS basalis comprehensively, after concentrating, forms the uniform concentrated solution of material on SERS basalis surface; SERS basalis 2 can adopt the structure that embeds basalis 1 super-drainage structure surface 11, destroys and SERS basalis 2 super-drainage structure of the same size surface, and SERS basalis 2 is embedded and repaired, and can realize equally goal of the invention; Certainly, be directly positioned over super-drainage structure surface and also can realize goal of the invention.
In the present embodiment, SERS substrate 2 is positioned over described super-drainage structure surface, replaceable another piece SERS substrate after SERS substrate 2 is used, and super-drainage structure can continue to use, and has repeatability, saves use cost.
In the present embodiment, described SERS basalis is formed by filter paper 21 surface attachment surface accumulation layers 22; Adopt the basic unit of filter paper 11 as SERS basalis 2, there is ground unrest little; Can separate with sample, absorption, concentrated advantage; Certainly, can be also sand paper, lens paper or frosted glass etc., according to different requirements, adopt different materials.
In the present embodiment, the size of described SERS basalis 2 is the circle that diameter is less than 3 millimeters, is applicable to preferably drip solution and concentrates the mode detecting, and is adapted to the shape of drop; Certainly, can be also other arbitrary shape, but be unsuitable for standardized production, and have difference with droplet profile.
In the present embodiment, described basal layer 1 is arc groove shape structure, and described super hydrophobic surface 11 is the inside surface of arc groove shape structure, and described SERS basalis 2 is positioned at the bottommost of arc groove inside surface; There is good automatic positioning function, prevent from dripping the low problem of detection efficiency that cannot accurately locate after solution and cause.
In the present embodiment, surface accumulation layer 22 is layer of precious metal, and described layer of precious metal is any one in gold, silver, copper.
Finally explanation is, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is had been described in detail with reference to preferred embodiment, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement technical scheme of the present invention, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of claim scope of the present invention.
Claims (6)
1. a super-hydrophobic type SERS composite substrate, it is characterized in that: comprise basal layer and the SERS basalis with super hydrophobic surface, described SERS basalis embeds or is positioned over basalis super-drainage structure surface, and the size of described SERS basalis is less than a solution and is positioned at the drop size that super hydrophobic surface forms.
2. super-hydrophobic type SERS composite substrate according to claim 1, is characterized in that: SERS basalis is positioned over described super-drainage structure surface.
3. super-hydrophobic type SERS composite substrate according to claim 2, is characterized in that: described SERS basalis is formed by filter paper attaching surface enhancement layer.
4. super-hydrophobic type SERS composite substrate according to claim 3, is characterized in that: the size of described SERS basalis is the circle that diameter is less than 3 millimeters.
5. super-hydrophobic type SERS composite substrate according to claim 4, it is characterized in that: described basal layer is arc groove shape structure, described super hydrophobic surface is the inside surface of arc groove shape structure, and described SERS basalis is positioned at the bottommost of arc groove inside surface.
6. super-hydrophobic type SERS composite substrate according to claim 5, is characterized in that: surface accumulation layer is layer of precious metal, described layer of precious metal is any one in gold, silver, copper.
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| CN201310703564.7A CN103822912A (en) | 2013-12-19 | 2013-12-19 | Super hydrophobic type SERS (Surface-enhanced Raman scattering) composite substrate |
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| CN201310703564.7A CN103822912A (en) | 2013-12-19 | 2013-12-19 | Super hydrophobic type SERS (Surface-enhanced Raman scattering) composite substrate |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105021589A (en) * | 2015-06-18 | 2015-11-04 | 北京航空航天大学 | Method for preparing hydrophobic SERS substrate by using silk-screen printing technology |
| CN106814059A (en) * | 2017-01-16 | 2017-06-09 | 北京芯创睿胜科技有限公司 | SERS activity drop, preparation method and molecular detecting method |
| TWI604187B (en) * | 2016-07-20 | 2017-11-01 | 行政院農業委員會農業藥物毒物試驗所 | Surface-enhanced raman spectroscopy for rapid detection of active ingredients of pesticide products and pesticide residues in agricultural products |
| CN107580676A (en) * | 2015-07-29 | 2018-01-12 | 惠普发展公司，有限责任合伙企业 | Analyze analyte detection package casing |
| CN112067595A (en) * | 2020-07-29 | 2020-12-11 | 温州大学 | SERS substrate, preparation method thereof and detection device |
| CN112480459A (en) * | 2020-11-25 | 2021-03-12 | 浙江工业大学 | Groove-shaped super-hydrophobic truncated cone array surface for realizing liquid drop resilience |
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| CN102944543A (en) * | 2012-11-05 | 2013-02-27 | 中物院成都科学技术发展中心 | Method and device for detecting ultra trace sample based on surface-enhanced Raman spectroscopy |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105021589A (en) * | 2015-06-18 | 2015-11-04 | 北京航空航天大学 | Method for preparing hydrophobic SERS substrate by using silk-screen printing technology |
| CN107580676A (en) * | 2015-07-29 | 2018-01-12 | 惠普发展公司，有限责任合伙企业 | Analyze analyte detection package casing |
| US10571399B2 (en) | 2015-07-29 | 2020-02-25 | Hewlett-Packard Development Company, L.P. | Analyte detection package housing |
| TWI604187B (en) * | 2016-07-20 | 2017-11-01 | 行政院農業委員會農業藥物毒物試驗所 | Surface-enhanced raman spectroscopy for rapid detection of active ingredients of pesticide products and pesticide residues in agricultural products |
| CN106814059A (en) * | 2017-01-16 | 2017-06-09 | 北京芯创睿胜科技有限公司 | SERS activity drop, preparation method and molecular detecting method |
| CN106814059B (en) * | 2017-01-16 | 2019-06-14 | 北京芯创睿胜科技有限公司 | SERS activity drop, preparation method and molecular detecting method |
| CN112067595A (en) * | 2020-07-29 | 2020-12-11 | 温州大学 | SERS substrate, preparation method thereof and detection device |
| CN112067595B (en) * | 2020-07-29 | 2023-06-20 | 温州大学 | SERS substrate, preparation method thereof and detection device |
| CN112480459A (en) * | 2020-11-25 | 2021-03-12 | 浙江工业大学 | Groove-shaped super-hydrophobic truncated cone array surface for realizing liquid drop resilience |
| CN112480459B (en) * | 2020-11-25 | 2023-02-28 | 浙江工业大学 | Groove-shaped super-hydrophobic truncated cone array surface for realizing liquid drop resilience |
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