CN103768570B - A kind of Chinese medicine composition for the treatment of acute cholecystitis and preparation method thereof - Google Patents

Abstract

The invention belongs to medical art, relate to a kind of Chinese medicine composition for the treatment of acute cholecystitis and preparation method thereof.Chemotherapeutic agent liver toxicity for current acute cholecystitis is larger, the prior art of unsatisfactory curative effect is not enough, the Chinese medicine composition that a kind for the treatment of or prevention acute cholecystitis are provided of the present invention, it comprises following component: Herba Andrographis 10-50 part, Fructus Gardeniae 10-20 part, Flos Sophorae 5-20 part, Luo Xing grass 5-15 part, Radix Rehmanniae Preparata 5-10 part, Bulbus Lilii 5-15 part, Flos Lonicerae 5-15 part, Rhizoma Alismatis 1-10 part, Fructus Lycii 5-15 part, Fructus Cnidii 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, Herba Dichodrae 0.2-9 part, Radix Paeoniae Alba 5.5-15 part, Rhizoma Zingiberis 6-9 part, Radix Glycyrrhizae 10-15 part.This Chinese medicine composition all has good therapeutic effect in treatment or prevention acute cholecystitis, and drug side effect is low, has significant clinical generalization value.

Description

A kind of Chinese medicine composition for the treatment of acute cholecystitis and preparation method thereof

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine composition for the treatment of acute cholecystitis and preparation method thereof.

Background technology

Acute cholecystitis is the gallbladder inflammation caused due to cystic duct obstruction and bacteria attack; Its typical clinical is characterized as upper right abdomen paroxysmal colic, with significantly touch a tender spot and abdominal muscle tetanic.The patient of about 95% is associated with cholelithiasis, is called calcareous cholecystitis; The patient of 5% does not merge cholelithiasis, is called non-calcareous cholecystitis.Its pathogenic factor mainly contains following three kinds of reasons: 1. mechanicalness inflammation: because gallbladder cavity pressure raises, gallbladder wall and mucosa pressurized ischemia are caused; 2. chemical inflammatory: phospholipase acts on the lecithin in bile, produces LYSOLECITHIN SUNLECITHIN A, produces chemical inflammation; 3., there is bacterial inflammation in bacterial inflammation: lodge in gallbladder by escherichia coli, Klebsiella, streptococcus, staphylococcus etc.Bacterial inflammation accounts for the 50%-80% of acute cholecystitis.

Acute cholecystitis cardinal symptom is clinically right hypochondrial region, Nausea and vomiting and heating.There is right hypochondrial region in patient Chang Shouxian, take on back to the right and diffuse, pain is persistence, and paroxysmal is aggravated, and can be attended by Nausea and vomiting.Vomitus is Stomach duodenum content.Later stage performance heating, mostly is low grade fever, and shiver with cold, high heat is not common, early stage many without jaundice, when the concurrent inflammation of bile duct or inflammation cause portal lymph node enlargement, can occur jaundice.Local sign shows as patient's upper right abdomen tenderness, the patient of about 25% can touch enlargement gallbladder, patient is when dark air-breathing or cough, the finger be put under right rib can contact the gallbladder of enlargement, patient can stop air-breathing suddenly because of pain, upper right abdomen has tenderness, muscle tonus and rebound tenderness, when there will be the inflammation of full abdomen after perforation of gallbladder; Can there is yellow sclera in general physical checkup patient, have body temperature to raise, and pulse is accelerated, and accelerated breathing, blood pressure drops etc., as there is perforation of gallbladder, during increased inflammation, can show septic shock.

At present, the Western medicine for the treatment of acute cholecystitis is a lot, but most drug therapeutic effect is poor, and treats into the shortcomings such as high, side effect is large in addition, even affects patient health time serious.Antibiotic is better to the therapeutic effect of acute cholecystitis, but antibiotic life-time service can cause human body to produce antibiotic resistance, and its use can destroy the balance of intestinal microbial population, causes serious impact to the physical and mental health of patient.In addition, also have the Chinese medicine of a lot for the treatment of acute cholecystitis, but great majority have the shortcomings such as the low and treatment cycle of therapeutic effect difference, cure rate is long.Namely the object of the invention is to provide a kind of effect comprehensively, the Chinese medicine composition of the treatment acute cholecystitis that clinical effectiveness is good.

Acute cholecystitis belongs to sick categories such as Chinese medicine " gallbladder-distention " " hypochondriac pain " " stomachache " " jaundice ", and the many and eating and drinking without temperance of its cause of disease, disorder of emotion, the factors such as overstrain are relevant.Middle Jiao is held back in the thick greasy or unclean thing of surfeit delicious food and hungry immoderate, of a specified duration long-pending humidifying expectorant heat-dissipating heap soil or fertilizer over and around the roots of satisfying, so that liver and gall are lost in catharsis, thus gastral cavity side of body feeling of distension and oppression pain, nausea and vomiting; Or disorder of emotion, be worried angry, liver and gall dysfunction of acting as a pivot, bile is logical to fall freely, and stagnated QI transforming into fire, venation is become estranged, and then becomes hypochondriac pain, gallbladder-distention.

Make a general survey of the research direction of world's new drug, the eighties mainly researched and developed single chemicals and preparation thereof in the past, and start after the eighties to develop biotechnology and natural medicinal plants, drug research direction is tending towards multiformity.In conjunction with modern Chinese medicine theory of development, from improving curative effect of medication, reducing the angle of side effect, through carrying out to Chinese medicine ingredients the preparation that screening is extracted and/or compatibility is obtained, its side effect is little, and safety is high, has the advantage that chemical synthetic drug can not be compared.

Summary of the invention

In prior art, chemicals is cured the symptoms, not the disease, and easily damage is gastrointestinal tract mucous, and poisonous side effect of medicine is large, and it is fixed that Chinese medicine then exists uncertain therapeutic efficacy, lacks relative medicine preparation.Large in order to overcome existing acute cholecystitis chemotherapeutic agent toxic and side effects, the prior art that acute cholecystitis therapeutic effect is difficult to continue is not enough, the invention provides a kind of Chinese medicine composition for the treatment of acute cholecystitis, this Chinese medicine composition good effect, side effect is little, it obtains primarily of following raw material: Herba Andrographis 10-50 part, Fructus Gardeniae 10-20 part, Flos Sophorae 5-20 part, Luo Xing grass 5-15 part, Radix Rehmanniae Preparata 5-10 part, Bulbus Lilii 5-15 part, Flos Lonicerae 5-15 part, Rhizoma Alismatis 1-10 part, Fructus Lycii 5-15 part, Fructus Cnidii 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, Herba Dichodrae 0.2-9 part, Radix Paeoniae Alba 5.5-15 part, Rhizoma Zingiberis 6-9 part, Radix Glycyrrhizae 10-15 part.

Herba Andrographis: bitter in the mouth, cold in nature.GUIXIN, lung, large intestine, urinary bladder channel.Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom." Jiangxi medical herbs ": clearing away heat and cooling blood, reducing swelling and alleviating pain, controls cholecystitis, bronchitis, hypertension, pertussis.

Fructus Gardeniae: sweet, bitter, cold.Return liver, gallbladder, stomach warp.Clearing away heat-damp and promoting diuresis, cooling blood for hemostasis.Main icterohepatitis, dysentery, cholecystitis, the high heat of flu, spits blood, epistaxis, urinary tract infection, oedema due to nephritis, mastitis, acute toothache, sore and toxic, traumatic injury.

Flos Sophorae is again Chinese scholartree stamen, effect of Flos Sophorae: cooling blood for hemostasis, liver heat removing and eyesight improving, Flos Sophorae effect: control discharging fresh blood stool, hemorrhoid hematochezia, hematuria stranguria with blood, liver-heat headache, conjunctival congestion and swelling pain, Flos Sophorae medication is avoided: Deficiency and coldness of spleen and stomach person is careful takes Flos Sophorae, Flos Sophorae can (drugs) to be decocted and taken as a drink, Flos Sophorae also can be equal to use with Spica Prunellae, Flos Chrysanthemi, Radix Scutellariae, to increase the effect of purging liver-fire improving eyesight.Clinically to cure mainly: discharging fresh blood stool; Hemorrhoid hematochezia; Dysentery; Hematuria; Stranguria with blood; Metrorrhagia; Spit blood; Epistaxis; Liver-heat is had a headache; Conjunctival congestion and swelling pain; Carbuncle skin infection.

Luo Xingcao: bitter, cold.Heat-clearing and toxic substances removing, eliminating stasis to stop pain.Cure mainly hepatitis, cholecystitis, acute enteritis, dysentery, tonsillitis, injury and bone fracture, arthralgia.

Radix Rehmanniae Preparata is the tuber of scrophulariaceae rehmannia glutinosa plant, has another name called Radix Rehmanniae Preparata or throws oneself on the ground, forming through Processing methods.Radix Rehmanniae Preparata is a kind of first-class Chinese crude drug, has YIN nourishing effect of enriching blood, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, diseases such as also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, pass out semen, quench one's thirst is one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.Radix Rehmanniae Preparata is first appeared in Shennong's Herbal, and Clinical practice has fresh, raw, ripe three kinds.All there is the merit of YIN nourishing and the production of body fluid promoting, and control all cards of Yin and fluid deficiency.Radix Rehmanniae sweetness and bitterness Great Cold, though the power of YIN nourishing is weak, be longer than clearing away heat and cooling blood, pathogenic fire purging relieving restlessness, be used for heat in blood heresy and contain, syndrome of yin deficiency and depletion of fluid; The power of the sweet cold matter profit removing heat from blood of raw (do) Radix Rehmanniae is slightly inferior but be longer than the moon of the kidney that nourishes heart, Gu Xuereyin injure fever due to yin deficiency person suitable it; Radix Rehmanniae Preparata is sweet in flavor and warm in property, and enter Liver and kidney and the special nourishing the blood and yin of merit, life essence-filling, marrow-benefitting, all kidney-YIN being deficient, marrow virtual loss person, all can use it.Radix Rehmanniae Preparata is used for insufficiency of kidney-YANG, decline of the fire from the gate of life, aversion to cold and cold limbs, impotence and seminal emission, and urine loses drop, or the anorexia and loose stool of YANG failing to warm spleen-YANG, many product adapteds with the warming YANG such as Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, the meaning of this i.e. so-called " be apt to YANG invigorating person, must in treating YANG within YIN ".With controlling carbuncle of yin nature cold coagulation, the adapteds such as this product normal and Colla cornus cervi, Cortex Cinnamomi, Herba Ephedrae are with channel warming and blood nourishing, and cold expelling is promoted blood circulation.

The traditional Chinese medical science thinks that Bulbus Lilii has the effect of nourishing the lung to arrest cough, clearing away heart-fire for tranquillization, and especially fresh Bulbus Lilii is more sweet delicious.Bulbus Lilii is particularly suitable for foster lung, the people of nourishing the stomach eats, such as the patient of chronic cough, pulmonary tuberculosis, aphtha of the mouth and tongue, xerostomia, halitosis.Bulbus Lilii not only has good nutritious tonifying effect, and for the patient such as deficient syndrome, tuberculosis, neurosis is of great advantage after being ill, has good curative effect to various cancer.In the prevention and therapy of tumor, Bulbus Lilii is used for treatment pulmonary carcinoma, nasopharyngeal carcinoma, skin carcinoma etc.During the symptoms such as the body void occurred after carrying out radiotherapy to above-mentioned cancer is weak, xerostomia, vexed, dry cough expectorant, cook congee together with Semen oryzae sativae with fresh Bulbus Lilii, edible after calling in appropriate crystal sugar or Mel again, to the reaction of health invigorating, anticancer growth, alleviation radiotherapy, there is good effect.For another example, fresh Bulbus Lilii and white sugar are smash deposited affected part in right amount altogether, infiltration person hemorrhage to skin carcinoma ulceration also has certain therapeutical effect.

Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, gastroenteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Flos Lonicerae tea has unique weight losing function simultaneously, can also suppress and the pathogen killing bottleneck throat, have infection effect to old man and child.So, often take Flos Lonicerae soak or decoct be conducive to wind-fire conjunctival congestion, laryngopharynx swelling and pain, obesity, the hypertensive treatment of liver-heat disease regulating liver-QI pattern of fever and rehabilitation.

Rhizoma Alismatis is the tuber of Notes On Alism At Aceae Rhizoma Alismatis.Theory of Chinese medical science thinks that it is cold in nature, has effect of promoting diuresis to eliminate damp pathogen.Modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Rhizoma Alismatis and preparation modern times thereof are also used for the treatment of auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc.But Rhizoma Alismatis has liver toxicity, nephrotoxicity, it is improper to take, and liver, kidney can be allowed to occur swelling and other poisoning symptoms.

Fructus Lycii (formal name used at school: Lyciumchinense) is the multi-branched shrub plant of Solanaceae Lycium, and high 0.5-1 rice, can reach more than 2 meters during cultivation.All there is distribution both at home and abroad.Fructus Lycii whole body is precious, and bright Li Shizhen (1518-1593 A.D.) Compendium of Material Medica is recorded: " spring adopts Folium Lycii, name sky essence grass; Summer picks flowers, name Sempervivum tectorum; Qiu Caizi, name Fructus Lycii; Dong Caigen, name Cortex Lycii ".Fructus Lycii tender leaf also known as Fructus Lycii head, edible or make Fructus Lycii tea.Modern study, Fructus Lycii has reduction blood glucose, lipotropy, and can antiatherogenic effect.

Fructus Cnidii is the fruit of samphire cnidium monnieri.Another name: Serpentis rice, Serpentis pearl, Serpentis foxtail millet, cnidium monnieri core, cnidium monnieri reality, gas fruit, Radix Habenariae Dentatae, favus-infected head beggar, wild Fructus Foeniculi.There is warming the kidney to invigorate YANG; Removing dampness and killing parasites; Effect of dispelling wind for relieving itching.Control impotence in male; Scrotum pruritus due to damp pathogen; Woman's infertility; Cold-damp leukorrhagia; Pudendal pruritus swells and ache; Rheumatic arthralgia; Eczema scabies.The Tang Dynasty be used for sexual impotence and cold womb infertile.Fructus Cnidii has the merit of warming the kidney to activate YANG, the impotence in male that treatment deficiency of kidney yin causes, and woman's cold womb is infertile, can be equal to use with Fructus Lycii, Semen Cuscutae, Fructus Schisandrae Chinensis, Cortex Cinnamomi, mends fire, supporing yang emerging flaccidity with kidney tonifying; " prescriptions worth thousand gold " controls kidney yang deficiency and coldness, and the Radix Aconiti ball that sexual impotence does not rise, namely forms with this product compatibility.For man's scrotum pruritus due to damp pathogen, woman's pudendal pruritus leukorrhagia, eczema scabies.Fructus Cnidii can dampness dispel the wind, killing parasites for relieving itching.Control eczema scrotum, woman's pudendal pruritus band is many, can be alone or decoct soup washout with Radix Sophorae Flavescentis, Cortex Phellodendri, Alumen etc.

The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.The pungent temperature rise of this product is fallen apart, and all hyperactivity of YANG due to deficiency of YIN and excessive rising of liver-YANG person should not apply; Menorrhagia, anemia of pregnant woman also avoid use.

The Radix Angelicae Dahuricae, warm in nature, acrid in the mouth is micro-sweet, has expelling wind and removing dampness; Logical surreptitiously pain relieving; Effect of detumescence and apocenosis.Main headache due to common cold; Supraorbital bone pain; Toothache; Nasal obstruction; Nasal sinusitis; Domination of damp pathogen chronic diarrhea; Women leucorrhea; Ulcer sores; Venom.Clinical in headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.Also can be used for the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Rhizoma Atractylodis have drying damp and strengthening spleen, expelling wind and cold, effect of improving eyesight, and for dampness taste, distension and fullness in the abdomen, cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable.Control dampness taste, and see the thick disease such as turbid of distension and fullness in the abdomen, inappetence, fatigue and weakness, white and greasy fur, the normal and compatibility such as Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae is applied.

Herba Dichodrae: bitter, pungent, cool.Return lung, Liver Channel.Heat clearing away, dampness removing, removing toxic substances.To harness the Yellow River subcutaneous ulcer, dysentery, sand Stranguria, nebulousurine, edema, furuncle swelling toxin, traumatic injury, venom." Chinese Plants will ": all herbal medicine has the merit of clearing away heat and promoting diuresis, wind-expelling pain-stopping, hemostasia and promoting granulation, eliminating inflammation and expelling toxin, parasite killing.Can treating acute and chronic hepatitis, icterohepatitis, cholecystitis, nephritis, urinary system infection, tonsillitis, stomatitis and carbuncle furuncle treat poison, venom, acute mastitis, dysentery, malaria, pneumorrhagia etc.

The Radix Paeoniae Alba is the famous traditional parts of generic medicinal plants of China, and applicating history is long, and Radix Paeoniae begins to be loaded in Eastern Han Dynasty's Shennong's Herbal, is classified as middle product, and note has " main pathogen, the Radix Paeoniae Alba is suffered from abdominal pain, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating ".Nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, and spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, is with inferior disease.Modern pharmacology research display, paeoniflorin is to the intestine in vitro of Cavia porcellus, rat with in stomach motion, and rat uterus smooth muscle all shows suppression, and the contraction of energy caused by antagonize oxytocin; With acetic acid injection in mouse peritoneal, using writhing response as the index of pain, paeoniflorin has significant analgesic effect; The convulsions caused by extractum energy antagonism strychnine of Radix Paeoniae; Radix Paeoniae Alba decoct has bacteriostasis to dysentery bacterium in vitro, and preserved material also has inhibitory action to some pathogenic fungus.Paeoniflorin has cooling effect to white mice normal body temperature, also has refrigeration function to the mice of artificial fever.Antiinflammatory action is had to Rat Experimental metapedes sole of the foot edema; Paeoniflorin in vitro or intravenous injection time to adenosine diphosphate (ADP) induction rat platelet aggregation have inhibitory action; Paeoniflorin has obvious inhibitory action to the digestive tract in rats ulcer of bringing out due to tense and stimulation.

Rhizoma Zingiberis Shennong's Herbal is classified as middle product, and Rhizoma Zingiberis Recens " Mingyi Bielu " is classified as middle product.TAO Hong-Jing is called: " allly make Rhizoma Zingiberis method: water logging three days, peeling to be put in flowing water six, and more random peeling, then dries, and puts in Porcelain Jar and makes three, be into." Li Shizhen (1518-1593 A.D.) meaning Rhizoma Zingiberis makes it with female Rhizoma Zingiberis Recens, is good with fair and clear solid person, all also Yi Pao that is used as medicine use.Rhizoma Zingiberis is used for warm spleen sun, partially controls spleen-cold syndrome stomachache and has loose bowels.Can promote blood circulation by recuperating depleted YANG again, warming the lung to resolve fluid-retention, with controlling yang depletion syndrome, four cold of the limbs are inverse, faint pulse being about to disappear, and cold fluid-retention cough with asthma, and the cold physique back of the body is cold, the clear rare disease such as grade of abundant expectoration.

Chinese medicine composition of the present invention with except long-pending numbness, dispersing wind and cold, wind-damp dispelling, bone and muscle strengthening are for main standard, has significant antiinflammatory, analgesia and activating blood circulation to dissipate blood stasis effect after Chinese medicine composition combination of the present invention on Chinese medicinal components is selected.The parts by weight of the present invention to above-mentioned all taste Chinese medicine carry out preferably, preferred condition be after Chinese medicine and western medicine compatibility uses medicine to the enhancing of acute cholecystitis therapeutic effect.As a preferred embodiment of the present invention, Chinese medicine composition of the present invention obtains primarily of the raw material of following weight portion: Herba Andrographis 30 parts, Fructus Gardeniae 15 parts, 15 parts, Flos Sophorae, Luo Xing grass 10 parts, 8 parts, Radix Rehmanniae Preparata, Bulbus Lilii 10 parts, Flos Lonicerae 10 parts, Rhizoma Alismatis 6 parts, Fructus Lycii 10 parts, Fructus Cnidii 12 parts, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 10 parts, Herba Dichodrae 5.5 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Zingiberis 8 parts, 12 parts, Radix Glycyrrhizae.

Preferably, Chinese medicine composition of the present invention also contains Rhizoma Cimicifugae 5 parts further, Semen Cassiae 9 parts.Rhizoma Cimicifugae is the dry rhizome of ranunculaceae plant C.heracleifolia, Cimicifuga Dahurica or Rhizoma Cimicifugae.Another name: all Rhizoma Cimicifugaes, Os Gallus domesticus Rhizoma Cimicifugae, funny face Rhizoma Cimicifugae, big cattle card holder, Radix Longan, hole root of the tooth.There is heat-clearing and toxic substances removing; Deliver rash; Effect of ascending up spleen-Qi and Yang.Spire can make cold vegetable dish in sauce equally, cooking or staple food dish filling.There is effect of removing toxic substances, sore-throat relieving, detumescence.Control gastritis, toothache, laryngopharynx swelling and pain, aphtha of the mouth and tongue etc.Semen Cassiae is the mature seed of leguminous plant Semen Cassiae and little Semen Cassiae.There is liver heat removing kidney tonifying, improving eyesight, effect of diuretic relieving constipation.Cure mainly conjunctival congestion and swelling pain, photophobia tear be many, optic atrohic blindness, nyctalopia, headache and dizzy, poor vision, cirrhotic ascites, dysuria, habitual constipation.External treatment toxic swelling, tinea disease.Effective in cure to wind heat acute conjunctivitis, hypertension, hepatitis, liver hard ascites habitual constipation etc.Semen Cassiae is used for the diseases such as conjunctival congestion and swelling pain, the many tear of photophobia, optic atrophy.Conjunctival congestion and swelling pain, the diseases such as the many tears of photophobia, are disturbing upward of liver-fire, or wind heat are stopped up caused by the head.Semen Cassiae can let out clearly liver and gall stagnated fire, again can dispelling wind and heat pathogens, for controlling conjunctival congestion and swelling pain key medicine.Wind heat person, normal being equal to Periostracum Cicadae, Flos Chrysanthemi, is used; Liver-fire person, often joins Radix Gentianae, Radix Scutellariae, the equivalent use of Spica Prunellae.Optic atrophy, how caused by deficiency of the liver and kindey.Semen Cassiae liver heat removing and improving eyesight, be often equal to use with tonic Liver and kidney medicine such as Semen Astragali Complanati, Fructus Ligustri Lucidi, Fructus Lycii, the Radix Rehmanniae, to control optic atrophy.Semen Cassiae bitter cold enters liver, can clearing away liver-fire, and holding concurrently again can suppressing liver-YANG, therefore the available headache, dizzy controlling excessive rising of liver-YANG, and it is medicinal often to join Flos Chrysanthemi, Ramulus Uncariae Cum Uncis, Spica Prunellae etc.Semen Cassiae nature and flavor are sweet salty-cold, double enter large intestine channel and can clearing away heat and moistening the bowels relieving constipation, for interior-heat dryness of the intestine, constipation, can be equal to Fructus Cannabis, Semen Trichosanthis and use.

In order to express Chinese medicine composition of the present invention better, Chinese medicine composition of the present invention can be prepared into dosage form conventional clinically.Such as, the preparation such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule.Preferably, Chinese medicine composition of the present invention conveniently preparation technology be prepared into powder, water preparation, tablet or capsule.

Present invention also offers a kind of preparation method of Chinese medicine composition described above, it mainly comprises following step: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, the alcoholic solution that volumetric concentration is 40%-95% is doubly added according to the 4-9 of coarse powder gross weight, reflux, extract, three times, return time is 2-5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art can technically prepare conventional Chinese medicine pharmaceutical dosage form clinically, as tablet, capsule etc. in this preparation method.

The present invention also asks to protect the purposes of above-mentioned Chinese medicine composition in preparation treatment acute cholecystitis medicine.Pharmaceutical composition of the present invention, when treating acute cholecystitis, demonstrates significant anti-inflammatory and antalgic, activating blood circulation to dissipate blood stasis is active.Test examples 19 of the present invention shows, compare with model group, low middle high three the dosage groups of Chinese medicine composition of the present invention all significantly can reduce the ear swelling value (P<0.01) of dimethylbenzene induced mice, show that Chinese medicine composition of the present invention has the effect of the mice ear significantly suppressing dimethylbenzene induction, and there is significant dose-effect relationship to the reduction effect of ear swelling in it.Under same experiment condition, positive control drug enteritis curing capsule group also significantly reduces ear swelling value (P<0.05), but its antiphlogistic effects is obviously not as good as Chinese medicine composition of the present invention.Test examples 20 of the present invention shows, mice licks foot response latency time showing, compare with model group, after administration after 1h and 2h, the incubation period that the mice of each administration group of Chinese medicine composition of the present invention adds foot reaction is all greater than model group, there is dose-dependence, and be significantly greater than model group (P<0.05) incubation period of high dose group.What illustrate that this Chinese medicine composition of the present invention can extend that mice stimulates hot plate adds the sufficient response latency, has certain analgesic activity.Under same experiment condition, positive control drug Rifaximin capsule group (P<0.05) and enteritis curing capsule group (1h, P<0.05; 2h, P<0.01) also significant prolongation mice add the incubation period of foot reaction, have certain analgesic activity.Test examples 21 of the present invention shows, and model group compares with normal control, and the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have and significantly increase (P<0.05).Compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high all significantly or pole significantly reduce the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity, reduction amplitude amount effect relationship, wherein there were significant differences (P<0.05) for high dose.Under same experiment condition, positive control drug Rifaximin capsule group also reduces whole blood height cut index, the low cut index of whole blood, erythrocyte aggregation index, but its to the improvement effect of hemorheology index all not as good as Chinese medicine composition of the present invention.The result statistics display of liver index, model group compares with normal control, and liver index significantly increases.And compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high significantly reduces liver index (P<0.01), positive control drug Rifaximin capsule and Chinese medicine composition of the present invention Chinese medicine composition high dose group of the present invention can reduce liver index (P<0.05) significantly, but effect is not as good as Chinese medicine composition of the present invention.Embodiment 22 result shows, Chinese medicine composition of the present invention all has good fungistatic effect to most pathogenic entero becteria, this shows that the acute cholecystitis that Chinese medicine composition of the present invention causes for various bacteria or fungus all has significant therapeutic effect, can play the effect for the treatment of both the principal and secondary aspects of a disease to infectious acute cholecystitis.And more estimable, containing plurality of active ingredients in Chinese medicine composition of the present invention, many for target spot during acute cholecystitis treatment of infection, not easily produce drug resistance, be significantly better than existing clinical in widely used antibiotics.

In a word, pharmaceutical composition of the present invention, in treatment acute cholecystitis, compared with prior art has following advantage:

1) compared with positive control drug Rifaximin capsule or enteritis curing capsule, pharmaceutical composition Chinese medicine composition of the present invention not only antiinflammatory and ease pain more remarkable, and also significantly positive drug is better than in activating blood circulation to dissipate blood stasis, this shows that the present composition has significant synergism in acute cholecystitis treatment, significantly can not only improve the symptom of acute cholecystitis, the development of acute cholecystitis can also be delayed, contribute to the recovery process of acute cholecystitis patient;

2) compared with the chemotherapeutic agent of Current therapeutic acute cholecystitis, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, particularly it does not produce any destruction for intestinal mucosa, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, significantly improves the compliance of acute cholecystitis patient, and improves the quality of life of patient;

3) existing antibiotic medicine acute cholecystitis initial therapy effect still can, but all occur obvious drug resistance problem along with the prolongation for the treatment of time, its therapeutic effect for acute cholecystitis declines; Containing multi-medicament component in Chinese medicine composition of the present invention, action target spot is numerous, efficiently solves the Commpensation And Adaptation of acute cholecystitis medicine, and it does not decline because treatment time extends to the therapeutic effect of acute cholecystitis.

Detailed description of the invention

Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.

The preparation of Part I Chinese medicinal composition preparation of the present invention and using method thereof

Embodiment 1-6 Chinese medicine composition composition powders

Table 1 Chinese medicine composition composition powders of the present invention prescription

Embodiment 1 preparation method: get each medical material in compositions, conveniently technique grinds to form powdery, cross 100 mesh sieves, little fire drying is for subsequent use.During use, directly take after mixing it with water with after water dissolution.Embodiment 2-6 preparation method is with embodiment 1.

Embodiment 7-12 Chinese medicine composition water preparation

Table 2 Chinese medicine composition water preparation of the present invention prescription

Embodiment 7 preparation method: get each medical material in prescription, conveniently decocting for Chinese herbal medicine technological operation, filtering medicinal residues and get final product.When this water preparation (or claiming decoction) is treated for acute cholecystitis, daily 2-3 time.Embodiment 8-12 preparation method and using method are with embodiment 7.

Embodiment 13-18 Chinese medicine composition tablet/capsule of the present invention

Table 3 Chinese medicine composition tablet of the present invention/capsule prescription

Embodiment 13 preparation technology: each traditional Chinese medicine powder getting recipe quantity is broken into coarse powder, adds according to 5 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 80%, reflux, extract, three times, the each 3h of return time, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; By Chinese medical concrete drying, pulverize and make dried cream powder, then add customary adjuvant components utilising prior art and be prepared into tablet or capsule.Embodiment 14-18 preparation technology is with embodiment 13.

Part II Chinese medicine composition pharmacodynamic study of the present invention

Embodiment 19 Chinese medicine composition xylol of the present invention causes the impact of mice ear

Get healthy ICR mice 72, ♀ ♂ half and half, divide 6 groups, 12/group, i.e. model group, Rifaximin capsule (Hainan company limited of SANYE pharmaceutical factory, lower same), enteritis curing capsule group (Haikou Kangliyuan Pharmaceutical Co., Ltd), Chinese medicine composition of the present invention (obtaining by Chinese medicine composition prescription described in embodiment 1 and preparation technology) low dose group, middle dosage group and high dose group.Every ig administration 1 time/d; Administration 14d, 60min after last medicine, mouse right ear uniform application dimethylbenzene 0.03mL/ only causes swollen, cuts ears and beat auricle and weigh after 2h, calculates ear swelling value (mg).Swelling value=auris dextra weight-left ear weight.

Result shows, compare with model group, low middle high three the dosage groups of Chinese medicine composition of the present invention all significantly can reduce the ear swelling value (P<0.01) of dimethylbenzene induced mice, show that Chinese medicine composition of the present invention has the effect of the mice ear significantly suppressing dimethylbenzene induction, and there is significant dose-effect relationship to the reduction effect of ear swelling in it.Under same experiment condition, positive control drug enteritis curing capsule group also significantly reduces ear swelling value (P<0.05), but its antiphlogistic effects is obviously not as good as Chinese medicine composition of the present invention.

The impact of table 4 Chinese medicine composition xylol of the present invention induced mice ear swelling

Note: compare with model group, * P<0.05, * * P<0.01.

Embodiment 20 Chinese medicine composition of the present invention affects mouse hot-plate analgesic

1 mouse hot-plate pain model makes

About body weight 20g female mice is placed on hot plate dolorimeter, screen qualified ♀ mice 90 (to lick metapedes time <5s or >30s to throw aside, scald for preventing foot, also deadline should be established, be generally 60s), the incubation period of metapedes reaction is added for threshold of pain index with mice, get 72 jennies, be divided into 6 groups, 12/group, i.e. model group, Rifaximin capsule, enteritis curing capsule group, Chinese medicine composition of the present invention (obtaining by Chinese medicine composition prescription described in embodiment 1 and preparation technology) low dose group, middle dosage group and high dose group.Each group is gastric infusion, 1 times/day.

Chinese medicine composition of the present invention is on the impact of licking the foot response latency in mouse hot-plate analgesic experiment

Mice licks foot response latency time showing, compare with model group, after administration after 1h and 2h, the incubation period that the mice of each administration group of Chinese medicine composition of the present invention adds foot reaction is all greater than model group, there is dose-dependence, and be significantly greater than model group (P<0.05) incubation period of high dose group.What illustrate that this Chinese medicine composition of the present invention can extend that mice stimulates hot plate adds the sufficient response latency, has certain analgesic activity.Under same experiment condition, positive control drug Rifaximin capsule group (P<0.05) and enteritis curing capsule group (1h, P<0.05; 2h, P<0.01) also significant prolongation mice add the incubation period of foot reaction, have certain analgesic activity.The results are shown in Table 5.

Table 5 mice licks foot response latency timetable

Note: compare with model group, * P<0.05, * * P<0.01.

Embodiment 21 Chinese medicine composition of the present invention is to the improvement result of rat blood stasis models

Get healthy SD rat, body weight 180-200g, 70, male and female half and half, be divided into 7 groups at random by body weight: Normal group, model group, Rifaximin capsule group, enteritis curing capsule group and basic, normal, high group of Chinese medicine composition of the present invention (obtaining by Chinese medicine composition prescription described in embodiment 1 and preparation technology), often organize 10.Gastric infusion, successive administration 14 days, Normal group and model group are to 0.5%CMC, and all the other give corresponding drug administration.13rd day, 14 days, except Normal group, all the other treated animals pressed 1mg/kg subcutaneous injection adrenalin hydrochloride, 2 times/day, interval 4h, and after first time injection, animal is put into 15min in 4 DEG C of frozen water by 2h.Administration is got 4-5ml blood anticoagulant heparin on the 15th day and is measured blood rheology parameter, gets liver and to weigh conversion organ coefficient.

Dosage is as table 7.

Result shows, and model group compares with normal control, and the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have and significantly increase (P<0.05).Compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high all significantly or pole significantly reduce the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity, reduction amplitude amount effect relationship, wherein there were significant differences (P<0.05) for high dose.Under same experiment condition, positive control drug Rifaximin capsule group and enteritis curing capsule group also reduce whole blood height cut index, the low cut index of whole blood, erythrocyte aggregation index, but its to the improvement effect of hemorheology index all not as good as Chinese medicine composition of the present invention.The result statistics display of liver index, model group compares with normal control, and liver index significantly increases.And compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high significantly reduces liver index (P<0.01), positive control drug Rifaximin capsule and Chinese medicine composition of the present invention Chinese medicine composition high dose group of the present invention can reduce liver index (P<0.05) significantly, but effect is not as good as Chinese medicine composition of the present invention.

Table 6 Chinese medicine composition of the present invention is on the impact of rat blood stasis models lectin from hemolymph

Note: compare with normal control, #P<0.05, ##P<0.01; Compare with model group, * P<0.05, * * P<0.01

Table 7 Chinese medicine composition of the present invention is on the impact of rat blood stasis models liver coefficient

Note: compare with normal control, ##P<0.01; Compare with model group, * P<0.05, * * P<0.01.

Embodiment 22 Chinese medicine composition of the present invention is to the antibacterial experiment in vitro of common enteropathic antibacterial

1, experiment material and method

The strain that this experiment uses and culture medium are respectively Candida albicans, dysentery bacterium, colon bacillus, proteus vulgaris, Salmonella, shigella dysenteriae, staphylococcus aureus, resistance to methoxy staphylococcus aureus and campylobacter jejuni, clostridium perfringens enterotoxin, nutrient agar (Nat'l Pharmaceutical & Biological Products Control Institute); Opacity tube (Chinese bacterial turbidity standard, Chinese medicine biological combinations calibrating institute).

Antibacterial experiment in vitro: 1. prepare pastille agar plate; Tested material is pressed the culture medium of doubling dilution preparation different pharmaceutical concentration, heating, modulation is required pH value separately, and 121 DEG C of sterilizing 30min, are chilled to 45 DEG C; Pour into into aseptic flat board (plate d=65mm, 10ml/ plate), finally make the extension rate containing tested material stock solution (2g/ml) in culture medium be respectively l: 2,1: 4 ... 1: 1024; Do respective blank culture medium simultaneously; 2. inoculate; Get the bacterium in young age reaching the third generation, be the bacterium liquid to be checked of 108cfu/ml respectively by standard opacity tube corrected concentrations with 0.9% sodium chloride solution, be inoculated in the respective pastille agar surface of different doubling dilution respectively, Simultaneous vaccination parallel point 3 point, make at often containing 2 one bacterium liquid; The liquid-drop diameter of each vaccination is 5-8mm; After point to be seeded drying, upset is dull and stereotyped cultivates 20h observed result (simultaneously doing blank) in 36 DEG C of constant incubators; 3. criterion; Not occur that minimum dilution tested material concentration on the agar plate of bacterium colony is for its minimum inhibitory concentration (MIC); In this experiment, the minimal inhibitory concentration of Chinese medicine composition to each pathogenic strain is as shown in table 8.

Experimental result and analysis

The minimal inhibitory concentration measurement result that table 8 arctigenin is lived common pathogen

Result shows, Chinese medicine composition of the present invention all has good fungistatic effect to most pathogenic entero becteria, this shows that the acute cholecystitis that Chinese medicine composition of the present invention causes for various bacteria or fungus all has significant therapeutic effect, can play the effect for the treatment of both the principal and secondary aspects of a disease to infectious acute cholecystitis.And more estimable, containing plurality of active ingredients in Chinese medicine composition of the present invention, many for target spot during acute cholecystitis treatment of infection, not easily produce drug resistance, be significantly better than existing clinical in widely used antibiotics.

The clinical data of embodiment 23 traditional Chinese medicine composition for treating acute cholecystitis of the present invention:

Case selection: select acute cholecystitis patient 200 example in year June in March, 2011 to 2013, wherein male 95 example, women 105 example; Age 15-73 year, average (34 ± 8) year; All have stomachache, heating, stomachache be positioned at right upper quadrant of the abdomen or xiphoid-process under and with Nausea and vomiting person 184 example, body temperature 37.5-38.9 DEG C person 142 example; There is jaundice person 115 example, neutrophilic leukocyte rising person 168 example.Treatment group and each 100 examples of matched group are divided into by random digits table.The no significant differences (P>0.05) such as two groups of Genders, age, symptoms, have comparability.

Diagnostic criteria: formulate 1. symptom with reference to " clinical disease diagnosis is according to curing improvement standard ": upper right abdomen constant pain, paroxysmal increases the weight of, and shoulder radiation to the right, companion's Nausea and vomiting and heating; 2. sign: upper right abdominal pressure pain, muscle tonus, Fei Shi does not levy the positive, sometimes can lay one's hand on and tool touch a tender spot enlargement gallbladder; 3. blood test: total white blood cells and neutrophil count significantly raise, part has liver function change, serum total bilirubin slightly increases; 4. ultrasound diagnosis: gollbladder dilation, cyst wall thickens, visible foreign matters ripple, light group, sound shadow.

Excluded cases standard: 1. have the important organ dysfunction persons such as severe cardiac, liver, kidney; 2. gestation or women breast-feeding their children, allergic constitution person; 3. be associated with severe complication and be badly in need of operative treatment person, as perforation of gallbladder, acute diffuse peritonitis or Acute necrotising pancreatitis etc.; 4. single calculus >0.5cm person is pointed out in ultrasound diagnosis; 5. ultrasound diagnosis prompting neck of gallbladder does not obviously block person; 6. Subtotal gastrectomy art was done, especially BillrathII formula person.

Therapeutic Method: two groups of equal fasting, water (except medicine), to still need arrangement gastrointestinal decompression with serious vomiter, gives suitable fluid infusion, correct water and rock-soil coupling, maintain acid-base balance.Matched group routine uses antibacterials, based on third-generation cephalosporin and quinolones, adds use spasmolysis and analgesia medicine depending on the state of an illness.The tablet that treatment group adopts the embodiment of the present invention 1 to prepare; Every day 3 times, each 3.

Observation item: observe patient and to suffer from abdominal pain disappearance and abdominal distention remission time and other clinical symptoms and sign.

Curative effect judging standard: clinical cure: in 3d, symptom, sign are alleviated; In 7d, symptom, sign disappear, and lab testing indices is all normal; Effective: in 7d, symptom, sign significantly alleviate, every laboratory normally or only a little higher than normal value; Effective: in 7d, symptom, sign alleviate, every lab testing is significantly improved; Invalid: in 7d, symptom, sign have no obvious improvement, even worsen or turn operative treatment.

Table 9 Chinese medicine composition of the present invention is for the therapeutic effect of cholecystitis

Number of white blood cells before and after table 10 acute cholecystitis patient treatment

Claims (6)

1. treat a Chinese medicine composition for acute cholecystitis, it is characterized in that being obtained by the raw material of following weight portion: Herba Andrographis 10-50 part, Fructus Gardeniae 10-20 part, Flos Sophorae 5-20 part, Luo Xing grass 5-15 part, Radix Rehmanniae Preparata 5-10 part, Bulbus Lilii 5-15 part, Flos Lonicerae 5-15 part, Rhizoma Alismatis 1-10 part, Fructus Lycii 5-15 part, Fructus Cnidii 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, Herba Dichodrae 0.2-9 part, Radix Paeoniae Alba 5.5-15 part, Rhizoma Zingiberis 6-9 part, Radix Glycyrrhizae 10-15 part.

2. treat a Chinese medicine composition for acute cholecystitis, it is characterized in that: described Chinese medicine composition is made up of the traditional Chinese medicine composite of weight portion described in claim 1 and Rhizoma Cimicifugae 5 weight portion, Semen Cassiae 9 weight portion.

3. the Chinese medicine composition for the treatment of acute cholecystitis as claimed in claim 1, is characterized in that being obtained by the raw material of following weight portion: Herba Andrographis 30 parts, Fructus Gardeniae 15 parts, 15 parts, Flos Sophorae, Luo Xing grass 10 parts, 8 parts, Radix Rehmanniae Preparata, Bulbus Lilii 10 parts, Flos Lonicerae 10 parts, Rhizoma Alismatis 6 parts, Fructus Lycii 10 parts, Fructus Cnidii 12 parts, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 10 parts, Herba Dichodrae 5.5 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Zingiberis 8 parts, 12 parts, Radix Glycyrrhizae.

4. the Chinese medicine composition of the treatment acute cholecystitis as described in as arbitrary in claim 1-3, is characterized in that it is powder, water preparation, tablet or capsule.

5. one kind prepare as arbitrary in claim 1-3 as described in the method for Chinese medicine composition for the treatment of acute cholecystitis, it is characterized in that it comprises the following steps: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, the alcoholic solution that volumetric concentration is 40% ~ 95% is added according to 4 ~ 9 times of coarse powder gross weight, reflux, extract, three times, return time is 2 ~ 5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying.

6. the purposes of the Chinese medicine composition as described in as arbitrary in claim 1-3 in preparation treatment acute cholecystitis medicine.