CN103749822A

CN103749822A - Fructus ligustri lucidi health-care tea for lowering blood pressure and lipid and preparation method thereof

Info

Publication number: CN103749822A
Application number: CN201310750639.7A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Shandong Xinxi'an Pharmaceutical Co., Ltd.
Priority date: 2013-12-31
Filing date: 2013-12-31
Publication date: 2014-04-30
Anticipated expiration: 2033-12-31
Also published as: CN103749822B

Abstract

The invention provides fructus ligustri lucidi health-care tea for lowering blood pressure and lipid. The fructus ligustri lucidi health-care tea for lowering the blood pressure and the lipid is prepared from the following raw materials in parts by weight: 10-50 parts of fructus ligustri lucidi, 10-20 parts of crataegus pinnatifida bunge, 10-20 parts of prepared polygonum multiflorum thunb, 10-20 parts of elsholtzia ciliata, 10-20 parts of rhizoma polygonati, 10-20 parts of rehmannia glutinosa libosch, 10-20 parts of semen cassiae, 10-20 parts of lalang grass rhizomes, 10-20 parts of poria cocos, 10-20 parts of salvia miltiorrhiza, 10-20 parts of codonopsis pilosula, 10-20 parts of radices trichosanthis, 10-20 parts of gynostemma pentaphylla, 10-20 parts of white mulberry root barks, 10-20 parts of pericarpium citri reticulatae, 10-20 parts of astragalus mongholicus, 10-20 parts of inula flowers, 10-20 parts of bighead atractylodes rhizomes and 10-20 parts of cortex lycii radicis. According to the fructus ligustri lucidi health-care tea, the fructus ligustri lucidi contains a lot of oleanolic acid so as to accelerate the mobility of blood platelet cells and weaken the collision of blood platelets; the blood platelets are not easy to stick and collect and are not easy to deposit in the endangium; the thrombosis is relieved or prevented and the deposition of lipid intima can also be reduced; the microcirculation can be improved; the mouth feel of the almost medicinal materials is light and the taste of the tea is not influenced so that the tea is easily accepted by people and the effects of lowering the blood pressure and the lipid can be realized.

Description

A kind of fruit of glossy privet hypertension and hyperlipemia health protection tea and preparation method thereof

Technical field

The present invention relates to contain the health products that derive from plant composition, particularly a kind of fruit of glossy privet hypertension and hyperlipemia health protection tea and preparation method thereof.

Background technology

Blood fat mainly refers to cholesterol and the triglycerides in serum.No matter be that cholesterol level increases, or the increased content of triglyceride, or both all increase, and are referred to as hyperlipidemia.This disease to the infringement of health be concealment, gradually, carrying out property and general, its direct infringement is to accelerate systemic atherosclerosis, because the vitals of whole body all will rely on artery blood supply, oxygen supply, once artery is stopped up by atheromatous plaque, will cause serious consequence.The renal failure that artery sclerosis causes etc., all closely related with hyperlipemia.Research datas show in a large number, and hyperlipemia is cerebral apoplexy, coronary heart disease, myocardial infarction, cardiac sudden death is independent and important hazards.A large amount of medical researches show: the methods for the treatment of of high fat of blood can not, only by drug-layer side, also will be careful taking good care of of health.The expert who endeavours the research of anion Natural medicine claims: negative oxygen ion treatment hyperlipidemia effect is remarkable, stable, have no side effect, and be improved the group effect of body function, raising resistance against diseases, be particularly useful for the person in middle and old age's hyperlipidemia patient with multiple chronic disease, be a kind of comparatively ideal non-drug therapy, be worthy to be popularized.

The concentration of the lipid compositions such as hyperlipemia plasma cholesterol, triglycerides, total fat surpasses arm's length standard.The main harm of hyperlipemia is to cause atherosclerotic, and then causes numerous relevant diseases, and wherein modal a kind of mortality disease is exactly coronary heart disease, and serious chylomicronemia can cause acute pancreatitis, is another mortality disease.

In addition, hyperlipemia is also an important risk factor that promotes hypertension, IGT, diabetes.Hyperlipemia also can cause fatty liver, cirrhosis, cholelithiasis, pancreatitis, fundus hemorrhage, blind, peripheral vascular disease, limping, hyperuricemia.Also can there are tendon shape, nodositas, palm plane and eye socket around xanthoma, embryotoxon etc. in some primary and familial hyperlipemia.Blood pressure is modal chronic disease, is also the topmost hazards of cardiovascular and cerebrovascular diseases, and cerebral apoplexy, myocardial infarction, heart failure and CKD are its major complications.Both domestic and external facts have proved, hypertension is the disease that can prevent and control, reduces hyperpietic's blood pressure level, can obviously reduce cerebral apoplexy and the events of heart attack, significantly improves patient's life quality, effectively reduces disease burden.Hypertensive harmfulness and patient's blood pressure level mutually outside the Pass, also depend on the situation of the other diseases of simultaneous other cardiovascular risk factors, target organ damage and merging.Therefore in hypertensive definition and classification, hypertensive diagnostic criteria is fixed on to systolic pressure >=140mmHg and (or) diastolic pressure >=90mmHg, according to blood pressure level, be divided into normally, outside normal high value blood pressure and 1,2,3 grade of hypertension, also according to the other diseases of hazards, target organ damage and merging simultaneously, carry out risk stratification simultaneously.

Prevalence of Hypertension raises with age growth; Women's illness rate before climacteric, a little less than the male sex, but raises rapidly after climacteric, even higher than the male sex; High latitude cold district illness rate is higher than the warm area of low latitudes, and high altitude localities is higher than low altitude area; Relevant with eating habit, salt and saturated fat are taken in higher, and mean blood pressure level and illness rate are also higher.Population of China hypertension is popular two relatively outstanding features: from south to the north, Prevalence of Hypertension is and increases progressively trend; Between different nationalities, Prevalence of Hypertension also has some differences, the national illness rate of living in the north or highlands is higher, the national illness rate of living in south or non-highlands is lower, this species diversity may be relevant with geographical environment, life style etc., and not yet finding has obvious genetic background difference between various nationalities.

Treating hypertensive main purpose is to reduce to greatest extent cardiovascular morbidity and dead total danger, therefore require doctor in the hypertensive while for the treatment of, intervene the clinical disease that all invertibity cardiovascular risk factors of patient, target organ damage and merging exist.

Due to the prosperity day by day of economy, the continuous lifting of modern's living standard, causes too much the having deep love for of people to be enjoyed, and does not note oneself life style, behavioural habits, diet hobby, thus the disease causing.Society with fast rhythm's life, the operating pressure of keen competition, modern's physical and mental health has been caused to serious threat, make people more than half in sub-health state, show as: dizziness, nervous, weak, poor appetite, failure of memory, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, three a large amount of height (high heat, high protein, higher fatty acid), more than three, (anticorrisive agent is many, flavoring agent is many, hormone is many) residual agricultural chemicals in the absorption of food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise are less than normal, go down to make three high disease (hypertension for a long time like this, hyperglycaemia, high fat of blood), cardiovascular and cerebrovascular disease, cancers etc. so-called " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives that jeopardizes the mankind.

The high speed development of Modern Urban Living, also brings a series of rich man's diseases.Wherein " three height " and obesity are puzzlement people's primary enemies." three high diseases " refers to hypertension, hyperglycaemia (diabetes) and hyperlipemia.Conventionally be accompanied by obesity.They are " rich man's diseases " that modern society is derived from, and possible individualism also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipemia simultaneously, and high fat of blood is the principal element of artery sclerosis formation and development, and the poor aggravation blood pressure of arteriosclerotic's blood vessel elasticity raises, so the later stage has all formed " three high diseases ".About three height, be what has statistics, in the Chinese ten large causes of death, the death rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three height " also accounts for 27% of total death toll.High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented that the first line of defence of cardiovascular disease from reducing exactly " three height " and controlled " three height ".A lot of diabetes patients are with hyperlipidemia, so people call sister's disease diabetes and hyperlipidemia conventionally, and think that high fat of blood is the secondary disease of diabetes.About 40% diabetic has disorders of lipid metabolism according to statistics.Being characterized in that triglycerides increases with HDL reduces.

The fruit of glossy privet begins to be loaded in the < < of Eastern Han Dynasty Sheng Nong's herbal classic > > to be classified as top grade.< < Compendium of Materia Medica > > records: " it is verdant that this wood is insulted winter, the behaviour who has chastity to keep, thus with glossy privet shape it ... when near to put wax insect, therefore be commonly called as wax tree." < < Bencao Jingshu > > carries: " fruit of glossy privet, smell is all cloudy, is just entering kidney except the product of wanting of vulcanizing essence, kidney must be mended, the five internal organs are from peace, and spirit is self-sustaining, and all kinds of diseases and ailments are gone and body is fertile strong." < < book on Chinese herbal medicine is stated > > and carried: " Nuzhen, an ancient nationality in China, ancestors of the Manchus, who founded the Jin Dynasty is real, though enter sea of blood benefit blood, gentle above flourish ... by the main lung of kidney, and be skillful in up and down with excessive, lower only beard is for so also, extensively in heir side, multiplex." < < herbal classic meets former > > to carry: " Nuzhen, an ancient nationality in China, ancestors of the Manchus, who founded the Jin Dynasty, property is reported pure the moon, and taste is partially cold sliding, and the empty people of taste takes it, often subtracts food and rushes down." have stable political situation contained glossy privet and accompanying drawing in the books such as the standby herbal > > of history card class, < < Compendium of Materia Medica > >, < < Illustrated Book on Plants > > of < < rebuilding all refers to this kind, illustrates that medication is at all times consistent.

The fruit of glossy privet, sweet-bitter flavor, cool in nature, returns liver kidney channel, has the merit that nourishing liver and kidney, beneficial the moon nourishes blood.Modern medicine study proves, the fruit of glossy privet includes ursolic acid, sweet mellow wine, glucose, fatty wet goods, has cardiac stimulant, diuresis and hepatoprotective effect, can make the leucocyte decline quantity causing because of chemotherapy raise, and staphylococcus aureus, Escherichia coli are had to inhibitory action.

In the fruit of glossy privet, contain the acid of the oleanolic acid fruit of glossy privet, Ligustrum lucidum Ait, ursolic acid, stearic acid, oleic acid, sweet mellow wine, betulin, phosphatide and carbohydrate as Fructus Ligustri Lucidi polysaccharide, arabinose, glucose etc., also contain 15 seed amino acids, 11 kinds of trace elements and the wet goods that volatilizees.Research thinks that the fruit of glossy privet has hypoglycemic and reducing blood lipid and has study of anti-atherogenic effect, antibacterial, antivirus action in addition, and fruit of glossy privet decoction all has inhibitory action to staphylococcus aureus, shigella flexneri, typhoid bacillus, Pseudomonas aeruginosa and Escherichia coli.Type B adenovirus is had to medium degree inhibitory action.Increasing leukocyte: the fruit of glossy privet and component preparation thereof all have certain influence to haemocyte, it declines and has rising effect leucocyte due to chemotherapy.Compound containing the fruit of glossy privet also has effect in increasing leukocyte.Anti thrombotic action: oleanolic acid can be accelerated the mobility of platelet cell, weakened the collision between blood platelet, make it to be difficult for adhesion and gathering, more difficultly at endangium, deposit, slow down or prevent thrombosis, can reduce the deposition of lipid inner membrance again, for preventing and treating the elderly's thrombotic diseases, provide part experimental basis.Anti-ageing raising immunity: fruit of glossy privet decoction can make mouse immune organ thymus gland, spleen weight increase; Obviously improve mice serum hemolytic antibody active, the impact that mouse spleen lymphocyte is produced to proleulzin has dual regulation.The fruit of glossy privet has significant immunological enhancement, thereby it is anti-ageing to remove free radical.Application fruit of glossy privet control: angiocardiopathy, coronary heart disease, hyperlipidemia, diabetes, thrombopenia, leukopenia, chronic nephritis, chronic bronchitis, intractable aypnia, Chronic Benzene Poisoning, tumour, malnutrition, immunologic hypofunction disease, seborrhea.

Dragons and fishes jumbled together for various health products, the medicine sold on the market now, great majority are the amusement of false propaganda just, what have does not only have a health-care components, also cause the huge injury of the person, therefore, the effective hypertension and hyperlipemia method of search of health has very real significance, and hypertension and hyperlipemia active material is that people expect the key of dealing with problems always safely and effectively.The step-down of Chinese medicine hypoglycemic, have advantages of nontoxic, can be absorbed completely by organism, be the main direction that we study.Now market is in the urgent need to developing a kind of have reducing blood lipid, antibacterial, hypoglycemic, antioxidation, and can interference body to fatty absorption, the product that the fat that promotes to take in excretes, and have advantages of nontoxic, can be absorbed completely by organism.

Summary of the invention

Technical problem to be solved by this invention is, dragons and fishes jumbled together for various health products, the medicine sold on the market now, great majority are the amusement of false propaganda just, what have does not only have a health-care components, also cause the huge injury of the person, therefore, the effective hypertension and hyperlipemia method of search of health has very real significance.The fruit of glossy privet contains a large amount of oleanolic acids, can accelerate the mobility of platelet cell, weakened the collision between blood platelet, make it to be difficult for adhesion and gathering, more difficultly at endangium, deposit, slow down or prevent thrombosis, can reduce again the deposition of lipid inner membrance, for preventing and treating the elderly's thrombotic diseases, providing part experimental basis.The fruit of glossy privet has significant immunological enhancement, thereby it is anti-ageing to remove free radical.Application fruit of glossy privet control: angiocardiopathy, coronary heart disease, hyperlipidemia, diabetes, thrombopenia, leukopenia, chronic nephritis, chronic bronchitis, intractable aypnia, Chronic Benzene Poisoning, tumour, malnutrition.Add that some are promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, and can improve microcirculation, the most mouthfeel of these medicinal materials is light, does not affect tea flavour road, makes people be easy to acceptance, more can reach preferably the effect of hypertension and hyperlipemia.

For solving above-mentioned technical barrier, the invention provides a kind of fruit of glossy privet hypertension and hyperlipemia health protection tea, in described fruit of glossy privet hypertension and hyperlipemia health protection tea, the parts by weight of various raw materials are: 10～50 parts of the fruit of glossy privets, 10～20 parts of hawthorn, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of elscholtizas, 10～20 parts of sealworts, 10～20 parts, the dried rhizome of rehmannia, 10～20 parts of cassia seeds, 10～20 parts of cogongrass rhizomes, 10～20 parts, Poria cocos, 10～20 parts of the reds sage root, 10～20 parts of Radix Codonopsis, 10～20 parts of roots of Chinese trichosanthes, 10～20 parts of gynostemma pentaphylla, 10～20 parts of the root barks of white mulberry, 10～20 parts of dried orange peels, 10～20 parts of the Radixs Astragali, 10～20 parts of Inula britannica chinensis, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts of the root barks of Chinese wolf-berry.

Described fruit of glossy privet hypertension and hyperlipemia health protection tea, described in it, in fruit of glossy privet hypertension and hyperlipemia health protection tea, the parts by weight of various raw materials can be: 10～30 parts of the fruit of glossy privets, 10～15 parts of hawthorn, 10～15 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～15 parts of elscholtizas, 10～15 parts of sealworts, 10～15 parts, the dried rhizome of rehmannia, 10～15 parts of cassia seeds, 10～15 parts of cogongrass rhizomes, 10～15 parts, Poria cocos, 10～15 parts of the reds sage root, 10～20 parts of Radix Codonopsis, 10～20 parts of roots of Chinese trichosanthes, 10～20 parts of gynostemma pentaphylla, 10～20 parts of the root barks of white mulberry, 10～20 parts of dried orange peels, 10～20 parts of the Radixs Astragali, 10～20 parts of Inula britannica chinensis, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts of the root barks of Chinese wolf-berry.

Described fruit of glossy privet hypertension and hyperlipemia health protection tea, described in it, in fruit of glossy privet hypertension and hyperlipemia health protection tea, the parts by weight of various raw materials can also be: 10～40 parts of the fruit of glossy privets, 10～20 parts of hawthorn, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of elscholtizas, 10～20 parts of sealworts, 10～20 parts, the dried rhizome of rehmannia, 10～20 parts of cassia seeds, 10～20 parts of cogongrass rhizomes, 10～20 parts, Poria cocos, 10～20 parts of the reds sage root, 10～15 parts of Radix Codonopsis, 10～15 parts of roots of Chinese trichosanthes, 10～15 parts of gynostemma pentaphylla, 10～15 parts of the root barks of white mulberry, 10～15 parts of dried orange peels, 10～15 parts of the Radixs Astragali, 10～15 parts of Inula britannica chinensis, 10～15 parts of the bighead atractylodes rhizomes, 10～15 parts of the root barks of Chinese wolf-berry.

For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of fruit of glossy privet hypertension and hyperlipemia health protection tea, and described in it, the preparation process of fruit of glossy privet hypertension and hyperlipemia health protection tea comprises following aspect:

A. the preparation of the fruit of glossy privet;

B. by described other raw material soaking ethanol, heating, refluxing extraction 2 times;

C. the liquid again surplus stock being extracted is condensed into granule, pulvis or paste;

D. concentrated granule, pulvis or paste are mixed with the fruit of glossy privet preparing, be prepared into health care medicinal tea.

In described step a, in the time of can having white powder in annual fruit of glossy privet fruit blackening in December, lay, remove stalk, leaf and impurity, dry or put in hot water and scald and dry later; Then steeping in wine is one, steams and thoroughly dries, standby.

In described step b, can get in the ethanol that raw material adds 5-10 doubly to measure and soak 1-2 hour, heating is extracted 2 times, and each 1-2 hour, removes supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, 1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 ℃, heating is concentrated into paste, stand for standby use.

In described step c, the filtrate of filtration can be inserted in economic benefits and social benefits vacuum concentrator to the concentrate that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, then adds dextrin and puts into granulator and granulate.

In described steps d, the particle that the fruit of glossy privet preparing can be prepared with surplus stock mixes, and ultraviolet disinfection is packed and be get final product.

For solving the problems of the technologies described above, the present invention provides the preparation method of a kind of fruit of glossy privet hypertension and hyperlipemia health protection tea again, the process for producing granula of described fruit of glossy privet hypertension and hyperlipemia health protection tea can also be: all the other former parisons are entered to ethanol, heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged standing; Above-mentioned two kinds of extracts are merged, and decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 ℃ 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, and the medicinal extract that temperature to 60 is ℃-70 ℃, puts into oven drying and obtain powder, adds dextrin and granulates.

For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of fruit of glossy privet hypertension and hyperlipemia health protection tea, the paste preparation method of described fruit of glossy privet hypertension and hyperlipemia health protection tea can be: other raw materials are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, and 100-120 order filters, then through the molecular weight that dams, is the ultrafiltration post ultrafiltration of 5000-10000,1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 ℃, heating is concentrated into paste.

The technique effect that the present invention is useful is, the fruit of glossy privet contains a large amount of oleanolic acids, can accelerate the mobility of platelet cell, weakened the collision between blood platelet, make it to be difficult for adhesion and gathering, more difficult in endangium deposition, slow down or prevent thrombosis, can reduce the deposition of lipid inner membrance again, for preventing and treating the elderly's thrombotic diseases, provide part experimental basis.The fruit of glossy privet has significant immunological enhancement, thereby it is anti-ageing to remove free radical.Application fruit of glossy privet control: angiocardiopathy, coronary heart disease, hyperlipidemia, diabetes, thrombopenia, leukopenia, chronic nephritis, chronic bronchitis, intractable aypnia, Chronic Benzene Poisoning, tumour, malnutrition.Add that some are promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, and can improve microcirculation, the most mouthfeel of these medicinal materials is light, does not affect tea flavour road, makes people be easy to acceptance, more can reach preferably the effect of hypertension and hyperlipemia.The fruit of glossy privet contains a large amount of oleanolic acids, have hypotensive, reduce peripheral vascular resistance, coronary artery dilator, increase coronary flow, reduce MCO, cardiac stimulant, increase cardiac output, resist myocardial ischemia, platelet aggregation-against, improve hemorheological property, eliminate oxygen radical, fall the pharmacological actions such as excellent and constitution, enhancing hypoxia-bearing capability and diuresis.Clinical is all safe and effective for preventing and treating coronary disease and angina pectoris, hypertension, arrhythmia cordis and hyperlipidemia, atherosclerotic etc., is worthy of popularization.

The specific embodiment

The fruit of glossy privet: the fruit of glossy privet contains a large amount of oleanolic acids, can accelerate the mobility of platelet cell, weakened the collision between blood platelet, make it to be difficult for adhesion and gathering, more difficultly at endangium, deposit, slow down or prevent thrombosis, can reduce again the deposition of lipid inner membrance, for preventing and treating the elderly's thrombotic diseases, providing part experimental basis.The fruit of glossy privet has significant immunological enhancement, thereby it is anti-ageing to remove free radical.Modern pharmacological research shows, fruit of glossy privet decocting liquid has to rabbit experiment diabetes and hyperlipidemia the effect that reduces blood sugar and blood fat.The fruit of glossy privet is rich in bioflavonoid, linoleic acid, chromium element.That flavones not only can be is effectively promoting blood circulation and removing blood stasis, embolism resistance, reducing blood lipid, hypotensive, reduce cholesterol, reduce blood sugar, the composition of blood is purified, but also can improve microcirculation, reduce the fragility of capillary, reduce its permeability, can repair impaired vascular wall.

The fruit of glossy privet, sweet-bitter flavor, cool in nature, returns liver kidney channel, has the merit that nourishing liver and kidney, beneficial the moon nourishes blood.The fruit of glossy privet is the dry mature fruit of oleaceae plant glossy privet, and taste is sweet, bitter, cool in nature, returns liver kidney two warps.In the fruit of glossy privet, contain the acid of the oleanolic acid fruit of glossy privet, Ligustrum lucidum Ait, ursolic acid, stearic acid, oleic acid, sweet mellow wine, betulin, phosphatide and carbohydrate as Fructus Ligustri Lucidi polysaccharide, arabinose, glucose etc., also contain 15 seed amino acids, 11 kinds of trace elements and the wet goods that volatilizees.Research thinks that the fruit of glossy privet has hypoglycemic and reducing blood lipid and has study of anti-atherogenic effect, antibacterial, antivirus action in addition, and fruit of glossy privet decoction all has inhibitory action to staphylococcus aureus, shigella flexneri, typhoid bacillus, Pseudomonas aeruginosa and Escherichia coli.Type B adenovirus is had to medium degree inhibitory action.Increasing leukocyte: the fruit of glossy privet and component preparation thereof all have certain influence to haemocyte, it declines and has rising effect leucocyte due to chemotherapy.Compound containing the fruit of glossy privet also has effect in increasing leukocyte.Anti thrombotic action: oleanolic acid can be accelerated the mobility of platelet cell, weakened the collision between blood platelet, make it to be difficult for adhesion and gathering, more difficultly at endangium, deposit, slow down or prevent thrombosis, can reduce the deposition of lipid inner membrance again, for preventing and treating the elderly's thrombotic diseases, provide part experimental basis.Anti-ageing raising immunity: fruit of glossy privet decoction can make mouse immune organ thymus gland, spleen weight increase; Obviously improve mice serum hemolytic antibody active, the impact that mouse spleen lymphocyte is produced to proleulzin has dual regulation.The fruit of glossy privet has significant immunological enhancement, thereby it is anti-ageing to remove free radical.Application fruit of glossy privet control: angiocardiopathy, coronary heart disease, hyperlipidemia, diabetes, thrombopenia, leukopenia, chronic nephritis, chronic bronchitis, intractable aypnia, Chronic Benzene Poisoning, tumour, malnutrition, immunologic hypofunction disease, seborrhea.

Radix Codonopsis is the conventional traditional tonic of China, take Radix Codonopsis that area, Shangdang, Shanxi produces ancient times as top grade, has tonifying middle-Jiao and Qi, the effect of invigorating the spleen benefit lung.Modern study, Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, saponin and Alkaloid, has immunity, hemangiectasis, the step-down of enhancing, improves microcirculation, strengthens the effects such as hematopoiesis function.In addition leucocyte chemotherapy radiotherapy being caused declines castering action.Radix Codonopsis has tonifying middle-Jiao and Qi, the effect of invigorating the spleen benefit lung.For a little less than the spleen deficiency syndrome of the lung, the palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst etc.< < new compilation of materia medica > > records: " tonifying middle-Jiao and Qi and taste, relieving thirst and restlessness.Middle gas is faint, in order to adjust, mends, very smooth and proper.”

Gynostemma pentaphylla is found through modern medicine study, the main active ingredient of gynostemma pentaphylla is polysaccharide, flavonoids, saponins and microelement kind, its effect is mainly to promote body fat class metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in treatment and the health care of high fat of blood, fatty liver, obesity, constipation, insomnia, hepatitis B, chronic respiratory inflammation (sphagitis, enterogastritis etc.).

Poria cocos taste is sweet, light, property is flat, be used as medicine there is clearing damp and promoting diuresis, the function of beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is flat, enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, the effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed contrary, vomits contrary, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, reaches by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and due to insufficiency of the spleen dysfunction of the spleen in transportation and transformation, to have loose bowels, be with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.

Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also there is remarkable inhibitory action.< < property of medicine opinion > > carries it: monarch, taste is sweet, pungent, nontoxic.Can main large wandering arthritis, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, except fever and chills, lets out under only.Interarea light is happy, preserves youthful looks, and de-black.The swelling of harnessing the river is full, tells to vomit contraryly, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.

The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass caking, sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea, bitterly there is good effect.< < detailed outline > > carries: the red sage root, press the sensible opinion of < < married woman > > cloud, Siwu Tang is controlled gynecopathy, pay no attention to antenatal postpartum, how many through water, all can be general, the only taste red sage root is loose, cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, the stillborn foetus that falls, stop metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.

The Radix Astragali has the effects such as invigorating qi for strengthening superficies, sharp water detumescence, pus draining and toxin expelling, myogenic.The medicinal history of existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing various trace elements such as saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, anti-stress, step-down and antibacterial action more widely.But table is real evil, contain, retention of dampness due to stagnation of QI, dyspepsia is stagnated, ulcer from the beginning of or the real example such as routed after heat poison Shang Sheng.The Radix Astragali has invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, the effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, the uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult bursts, and bursts and does not hold back for a long time, and the deficiency of blood is sallow, and interior heat is quenched one's thirst.< < herbal classic > > records: " main ulcer, loses sore for a long time, apocenosis pain relieving.Qi-restoratives, children's's all kinds of diseases and ailments." < < Japan hanako materia medica > > record: " help gas to strengthen the bone, put on flesh and enrich blood.”

The dried rhizome of rehmannia: the dried rhizome of rehmannia is also radix rehmanniae recen, the fresh or dry piece root of Scrophulariaceae herbaceos perennial glutinous rehmannia Rehmannia glutinosa Libosch..Heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new, pain relieving, menstruation regulating, the metal-inflicted wound stasis of blood, cool blood, hemostasis; The effect of fresh rehmannia root and radix rehmanniae recen is different.Fresh rehmannia root clearing heat and promoting fluid, can stop blooding and cool blood, is often for consumption of YIN caused by febrile disease, the illnesss such as haematemesis, abscess of throat, the deep red polydipsia of tongue, a spot dermexanthesis and nosebleed heat.With respect to fresh rehmannia root, radix rehmanniae recen is heat clearing and blood cooling, also can promote the production of body fluid, and all right yin-nourishing is used for treating yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, the deep red polydipsia of tongue, sends out the problems such as spot dermexanthesis.The dried rhizome of rehmannia is cold in nature, and function is enriching yin and nourishing kidney.Not only promote the production of body fluid to quench thirst and heat clearing and blood cooling, also to metrorrhagia, irregular menstruation, fetal irritability, constipation etc., have effect, every blood system to have the people of thermal burn the moon, can often take.If want to treat warm heat disease, can do qingying decoction with the dried rhizome of rehmannia; If the later stage for the treatment of warm disease, because waste heat does not also disappear to the greatest extent, should be used for boiling Qinghao Biejia Tang the dried rhizome of rehmannia; In addition, for blood-head poison, contain, macula purple is black, and the serious heat of warm heat disease enters the symptom of ying blood, can take the Sisheng Wan that the dried rhizome of rehmannia is made; The general nourishing Yin and promoting production of body fluid of wanting treats that interior heat quenches one's thirst with constipation, should eat the once liquid soup that the dried rhizome of rehmannia boils.

The root bark of white mulberry is the root skin of moraceae plants mulberry Morus alba L..Main product in Anhui, the ground such as Henan, Zhejiang, Jiangsu, Hunan.Effect: removing heat from lung and relieving asthma, inducing diuresis for removing edema.For lung heat, cough and breathe heavily, the edema of the face, the diseases such as difficult urination.< < property of medicine opinion > >: make, flat.Can control lung qi and breathe heavily completely, aqueous vapor edema, main wound is exhausted, dredging water passages, the aqueous vapor that disappears, the headache of consumptive disease visitor heat, interior tonifying for the deficiency.< < Japan hanako materia medica > >: temperature, in tune, lower gas.Dissolving phlegm is quenched the thirst, sharp intestine and small intestine, and appetizing, lower food, kills abdomen and hides worm, and only cholera is vomited and diarrhoea.

Cogongrass rhizome cures mainly: cooling blood and hemostasis, and clearing heat and detoxicating.For spitting blood, hematuria, heat is drenched, oedema, jaundice, difficult urination, pyreticosis polydipsia, the stomach energy sound of vomiting of vomitting, coughs.< < herbal classic > >: " main internal lesion caused by overexertion void is thin, and tonifying middle-Jiao and Qi, except hemostasis, blood close fever and chills, diuresis." < < does not record > >: " lower five drenched, except visitor's heat is at stomach, quench the thirst, and hard muscle, married woman's metrorrhagia.", the just > > of < < book on Chinese herbal medicine: cogongrass rhizome, cold and cool and taste is very sweet, the heat that can purify the blood minute; and do not hinder dry; not sticky again, therefore cool blood and do not consider its long-pending stasis of blood is told nosebleed spitting blood to lead.Drop-down fire is contrary, and its effect is very prompt, therefore main stomach fire hiccup vomiting again, the lung heat circulation of vital energy in the wrong direction is breathed heavily full.And sweet cold and greasiness liquid, differs from bitter dryly though fall contrary, slakes thirst and help produce saliva again, and washs clearly the latent heat between lung stomach and intestine, can treat the paddy that disappears dry yearningly.Again can treating stranguria closing and control blood under haematuria, and housewife female's blood-heat bleeding, metrorrhagia is drenched band.The little water of tonneau again, the oedema of the knot that expels the heat-evil, leads the jaundice of stagnant heat, all sweet cold actual effect of removing heat by catharsis.So its sweet cold power, lets out clearly lung stomach, especially has speciality, and all dentalgia gums are swollen, and all sores of noma dispute, and the rotten all cards of the strongly fragrant pharyngalgia of stopping up of lung heat, make in order to assistant, and effect is the most outstanding, and without abuses.

Elscholtiza acrid-sweet flavor, warm in nature, nontoxic.Return lung, stomach, the spleen channel.Inducing sweat and dispelling exogenous evils, dampness elimination and in, inducing diuresis for removing edema; Sweating relieving summer-heat, row water is loose wet, during warm stomach is adjusted.Control the cold drink of Xia Yue sense cold, have a headache and fever, aversion to cold is lossless, feeling of stuffiness in chest stomachache, vomiting and diarrhoea, oedema, beriberi.Herba Moslae volatile oil all has stronger direct repression to the Ileum From A White Spontaneous Contraction activity of mouse, rat, cavy and rabbit, but different to the sensitiveness of the animal of different genera, by contrast, inhibitory action to cavy and Rabbit Ileum is stronger, effective dose 50 is respectively 3.6 and 7.6 μ g/ml, and to a little less than the effect slightly of rat and mouse, effective dose 50 is 14.2 and 35.1 μ g/ml.To GPI because of the caused anaphylaxis of egg shrink and barium chloride due to anaphylaxis contraction all have antagonism.< < book on Chinese herbal medicine > > cloud: main abdominal pain due to acute vomiting and diarrhea is told down, and aproll is swollen.

Sealwort is used as medicine with rhizome.There is boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney benefiting functions.Be used for the treatment of weakness of the spleen and the stomach, fatigue and asthenia, dry food is few, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, the interior heat disease such as quench one's thirst.Very effective in cure for diabetes.Stir-baked RHIZOMA POLYGONATI with yellow rice wine claims again to process sealwort.For steaming rear section with auxiliary materials such as wine and black soya beans, clean sealwort dries the person of being used as medicine.Have the merit of the channels and collaterals of escaping concurrently.Sealwort has hypotensive, hypoglycemic, reducing blood lipid, and atherosclerosis, delays senility and effect such as antibacterial grade, and Siberian solomonseal rhizome polysaccharide has Immunestimulatory effect.For the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, and the labor of the lung-kidney deficiency chronic cough etc. of coughing.For weakness of the spleen and the stomach.Both tonifying spleen-yin, beneficial temper again, for deficiency of kidney essence, obtain dizzy, soreness and weakness of waist and knees, poliosis and quenching one's thirst etc.Sealwort strengthens the bone, and beneficial marrow bleaches and sends out; The cough phlegm being suitable for due to lack of lung-YIN is few, dry cough without phlegm, the diseases such as hemoptysis.

Dried orange peel is warm in nature, and taste is pungent, bitter.Enter the spleen channel, stomach warp, lung channel.Regulating qi-flowing for strengthening spleen, in tune, eliminating dampness, reduces phlegm.Cure mainly the abdominal fullness and distention of the taste stagnation of the circulation of vital energy or pain, indigestion.Abdominal distension uncomfortable in chest, indigestion and loss of appetite loose stool in wet turbid resistance.The wet cough and asthma of stopping up lung of phlegm.For chest gastral cavity turgor, food is few vomits and diarrhoea, coughing with a lot of sputum.< < Compendium of Materia Medica > >: it is to hundred and always get the regulate the flow of vital energy merit of eliminating dampness of chess, mends with tonic, rushes down with cathartic, rises with hydrargyrum oxydatum crudum, falls with falling medicine.Spleen is the mother of vigour, and lung is to take the photograph wanting of gas, thus orange peel be two through gas, divide want, but with join and reinforcing and reducing methods lifting also.< < day is with herbal > >: can fall apart and can rush down, can temperature can mend, and the diaphragm gas that can disappear, the saliva that reduces phlegm, and spleen only coughs, and leads to five pouring.

Cassia seed bitter, sweet, salty, cold nature, enters liver, kidney, large intestine channel; Relax bowel, lipopenicillinase improving eyesight, treatment constipation and high fat of blood, hypertension.Clear liver and improve vision, sharp water defaecation, has laxative action, reducing blood pressure and blood fat.Cassia seed can be arranged in pairs or groups with other Herb Teas, has the good greasy effect of toxin expelling oil extraction.Can reach effect: the flat liver of heat-clearing, blood fat-reducing blood pressure-decreasing, relax bowel, improving eyesight benefit eyeball.Modern " TV family ", " cybraian " etc. easily cause that the crowd of eye fatigue might as well often drink, but preferably drink less night.

Hawthorn tepor is sweet, sour.Function stomach strengthening and digestion promoting is promoting blood circulation and removing blood stasis.Hawthorn energy prevention and cure of cardiovascular disease, has hemangiectasis, increases CF, improves heart vigor, stimulating central nervous system system, reduces blood pressure and cholesterol, softening blood vessel and diuresis and sedation.Hawthorn energy prevention and cure of cardiovascular disease, has hemangiectasis, cardiac stimulant, increase CF, improves heart vigor, stimulating central nervous system system, reduces blood pressure and cholesterol, softening blood vessel and diuresis and sedation; Prevent and treat artery sclerosis, anti-aging, anticancer effect.Crataegolic acid also has cardiotonic, also helpful to senile heart disease.Its energy appetite-stimulating indigestion-relieving, offsets carnivorous stagnant effect better especially, in a lot of digestant medicines, has all adopted hawthorn; Hawthorn has contraction to uterus, has the effect expediting the emergence of just before giving birth time, and can promote uterine involution in postpartum pregnant woman; Can strengthen the immunity of body, have anti-aging, anticancer effect.In hawthorn, having relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.

RADIX POLYGONI MULTIFLORI PREPARATA: the Chinese medicine fleece-flower root have Radix Polygoni Multiflori and RADIX POLYGONI MULTIFLORI PREPARATA minute, direct slicing is used as medicine for Radix Polygoni Multiflori, with black soya bean liquor, mixes after steaming and dries and be used as medicine for RADIX POLYGONI MULTIFLORI PREPARATA.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, the carbuncle that disappears, relax bowel, be usually used in treating scrofula sore carbuncle, rubella itch, the dry constipation of intestines; The filling liver kidney of RADIX POLYGONI MULTIFLORI PREPARATA function, benefiting essence-blood, black beard and hair, strengthening the bones and muscles, under sallow, the dizzy tinnitus of the deficiency of blood, poliosis, soreness and weakness of waist and knees, extremity numbness, uterine bleeding band, chronic malaria body void etc.RADIX POLYGONI MULTIFLORI PREPARATA of the present invention is the good merchantable brand of invigrating kidney.

Root of Chinese trichosanthes is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, is clearing heat-fire class medicine, and its concrete effect is clearing heat-fire, promote the production of body fluid to quench thirst, and apocenosis detumescence.Cure mainly: control pyreticosis thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle are swollen, hemorrhoid impotence.For treatment diabetes, conventional it and drugs for nourishing yin are used in conjunction with, to reach the effect for the treatment of both principal and secondary aspect of disease.< < book on Chinese herbal medicine converges says > >: root of Chinese trichosanthes, move back the five internal organs hot and suffocating, as internal heat, contain and dry tongue and mouth, lung-fire is contained and the swollen larynx numbness of pharynx, spleen fire is contained and dispute tooth is swollen, and convulsive seizure due to phlegm-fire is contained and cough is not peaceful.If the side of body of irascibility is swollen, walk note, the hectic fever due to yin dysphoria with smothery sensation of kidney fire, or ulcer bursts and do not burst, and hot poison is loose, or five subcutaneous ulcer yellow skin and eyes, and if if little water drenches puckeryly, be due to all burning hot pent-up, only convulsive seizure due to phlegm-fire, falls in this agent energy relieving stagnation, and can control it.Its property is sweet cold again, kindly can control yearningly, controls empty yearningly from tonic, controls fire thirsty from the medicine of a cold nature, controls strongly fragrant yearningly from gas medicine, from blood medicine, controls polydipsia, is to control thirsty key medicine also.

Inula britannica chinensis: bitter; Pungent; Salty; Tepor.Return lung; Stomach; Large intestine channel.Sending down abnormally ascending, dissolving phlegm, row water, preventing or arresting vomiting.For cough due to wind-cold evil, phlegm and retained fluid is held knot, and chest diaphragm ruffian is full, dyspnea and cough with excessive sputum, vomiting gas.< < Sheng Nong's herbal classic > >: " main knot gas hypochondrium fullness, palpitation with fear.Dewater, remove fever and chills between the five internal organs, bowl spares, lower gas." modern study, Inula britannica chinensis has protective effect to immunological liver injury, and its chemical composition gaillardin has antitumaous effect.In addition, its root and cauline leaf or aerial part also can be used as medicine, and control knife wound, serious case of furuncle, the decoction antibechic of can relievining asthma.

Root bark of Chinese wolf-berry heat-clearing, cool blood.Control consumptive disease hectic fever night sweat, lung heat is coughed and is breathed heavily, spit blood, and bleeding from five sense organs or subcutaneous tissue, blood drenches, quenches one's thirst, hypertension, carbuncle is swollen, dislikes sore.< < herbal classic > >: " main five interior perverse trends, hanker quenching one's thirst, general arthralgia." < < does not record > >: " main air is wet, lower breast side of body gas, and the headache of visitor's heat, mends internal injury great Lao suctions of hissing, hard muscle, reinforcing yin essence, sharp intestine and small intestine, heat resists cold.″

Specific embodiment 1:

First prepared by the fruit of glossy privet.

Again by all the other raw material hawthorn, RADIX POLYGONI MULTIFLORI PREPARATA, elscholtiza, sealwort, the dried rhizome of rehmannia, cassia seed, cogongrass rhizome, Poria cocos, the red sage root, Radix Codonopsis, root of Chinese trichosanthes, gynostemma pentaphylla, the root bark of white mulberry, dried orange peel, the Radix Astragali, Inula britannica chinensis, the bighead atractylodes rhizome, the root bark of Chinese wolf-berry, extracts concentrated granulation agent, pulvis or paste.

The fruit of glossy privet preparing and the extract of other raw materials, ultraviolet radiation for sterilizing and disinfecting pack, directly can take after mixing it with hot water during use.

Specific embodiment 2:

Fruit of glossy privet preparation: lay while having white powder in annual fruit of glossy privet fruit blackening in December, get the fruit of glossy privet 5000g obtaining to clean, remove stalk, leaf and impurity, dry or put in hot water and scald and dry later; Then with yellow rice wine, soak one, steam and thoroughly dry, standby.

Get all the other raw material hawthorn 1500g, RADIX POLYGONI MULTIFLORI PREPARATA 1500g, elscholtiza 1500g, sealwort 1500g, dried rhizome of rehmannia 1500g, cassia seed 1500g, cogongrass rhizome 1500g, Poria cocos 1500g, red sage root 1500g, Radix Codonopsis 1500g, root of Chinese trichosanthes 1500g, gynostemma pentaphylla 1500g, root bark of white mulberry 1500g, dried orange peel 1500g, Radix Astragali 1500g, Inula britannica chinensis 1500g, bighead atractylodes rhizome 1500g, root bark of Chinese wolf-berry 1500g, in the ethanol that adds 5-10 doubly to measure, soak 1-2 hour, heating is extracted 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 ℃, heating is concentrated into paste, stand for standby use.The filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator to the concentrate that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, then adds dextrin and puts into granulator and granulate.The particle that the fruit of glossy privet preparing is prepared with surplus stock mixes, and ultraviolet disinfection is packed and be get final product.

Specific embodiment 3:

While having white powder in annual fruit of glossy privet fruit blackening in December, lay, get the fruit of glossy privet 3500g obtaining to clean, remove stalk, leaf and impurity, dry or put in hot water and scald and dry later; Then with yellow rice wine, soak one, steam and thoroughly dry, standby; By surplus stock hawthorn 1200g, RADIX POLYGONI MULTIFLORI PREPARATA 1100g, elscholtiza 1200g, sealwort 1200g, dried rhizome of rehmannia 1200g, cassia seed 1100g, cogongrass rhizome 1200g, Poria cocos 1200g, red sage root 1100g, Radix Codonopsis 1200g, root of Chinese trichosanthes 1200g, gynostemma pentaphylla 1200g, root bark of white mulberry 1200g, dried orange peel 1200g, Radix Astragali 1200g, Inula britannica chinensis 1200g, bighead atractylodes rhizome 1200g, root bark of Chinese wolf-berry 1200g, is ground into particle, soaks 1 hour; Soaked bulk drug is put to boiling secondary in multi-function extractor; Add up for the first time the water of 10 times of amounts of medicinal material, decoct 1.5～2 hours, get decocting liquid, filter; Add up for the second time the water of 7 times of amounts of medicinal material, decoct 1～1.2 hour, get twice decocting liquid and mix, filter; The filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator to the concentrate that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds the agent of dextrin granulation.The fruit of glossy privet preparing is mixed with the granule of making, ultraviolet disinfection, packs and get final product again.

Specific embodiment 4:

While having white powder in annual fruit of glossy privet fruit blackening in December, lay, get the fruit of glossy privet 4500g obtaining to clean, remove stalk, leaf and impurity, dry or put in hot water and scald and dry later; Then with 60 degree white wine, soak one, steam and thoroughly dry, standby; By surplus stock hawthorn 1100g, RADIX POLYGONI MULTIFLORI PREPARATA 1100g, elscholtiza 1200g, sealwort 1200g, dried rhizome of rehmannia 1200g, cassia seed 1100g, cogongrass rhizome 1300g, Poria cocos 1200g, red sage root 1100g, Radix Codonopsis 1200g, root of Chinese trichosanthes 1200g, gynostemma pentaphylla 1200g, root bark of white mulberry 1100g, dried orange peel 1100g, Radix Astragali 1200g, Inula britannica chinensis 1200g, bighead atractylodes rhizome 1300g, root bark of Chinese wolf-berry 1200g, puts it in 10 times of water gagings and soaks.Drop into multi-function extractor and extract twice, add for the first time 8-10 times of water gaging and decoct 1-2 hour, add for the second time 4-8 times of water gaging and decoct 1-2 hour, merge twice decocting liquid, filter to get filtrate; Heating is concentrated into pasty state, then puts into baking oven inner drying powdered, and hybrid packed with the fruit of glossy privet preparing after ultraviolet radiation for sterilizing and disinfecting, during use, direct boiling water is taken after mixing it with water.

Pharmacology toxicity test

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixes decoction 2 times, merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, 10 every group, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of the maximum permission capacity of mouse, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose is measured (MTD value): get 20 of mouse, each 10 of male and female.Adding distil water of the present invention is dissolved, be made into maximum concentration, by the maximal tolerance dose of animal, to inject, fill with hello device and can twitch and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice (interval half an hour) in a day, each 0.5ml (every ml is containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.After administration, Continuous Observation is 7 days.

Three, result of the test:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, do not measure LD50, ask only maximum tolerated dose, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normally, there are no death.Select 300 times of doses that are equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation is 7 days, and none example is dead.Medicinal powder dosage is > 42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), by kg body weight, calculate the clinical consumption per day that is equivalent to be grown up 420 times.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give respectively rat the present invention and raise clothes, by adult 70 times of clinical consumption per day and 35 times (being 7g/kg/ day and 3.5g/kg/ day), to give and feed 8 weeks continuously, the behavior, feed, the body weight that have no rat occur extremely, with control group ratio, routine blood test, hepatic and renal function, various important organs are all without abnormal change, within the scope of institute's dosage, do not found any toxicity of the present invention.Acute and chronic toxicity test by animal confirms, safe range of the present invention is larger, is a kind of safe and reliable health products.

Pharmacological experiment:

The fruit of glossy privet: the fruit of glossy privet contains a large amount of oleanolic acids, can accelerate the mobility of platelet cell, weakened the collision between blood platelet, make it to be difficult for adhesion and gathering, more difficultly at endangium, deposit, slow down or prevent thrombosis, can reduce again the deposition of lipid inner membrance, for preventing and treating the elderly's thrombotic diseases, providing part experimental basis.The fruit of glossy privet has significant immunological enhancement, thereby it is anti-ageing to remove free radical.Modern pharmacological research shows, fruit of glossy privet decocting liquid has to rabbit experiment diabetes and hyperlipidemia the effect that reduces blood sugar and blood fat, existing for further study to its hypoglycemic decompression lipid-lowering effect, for the clinical use fruit of glossy privet provides theoretical foundation.

1 materials and methods

1.1 material

1.1.1 medicine: fruit of glossy privet health protection tea of the present invention boiling (embodiment of the present invention 2 methods are prepared), be prepared into the reagent containing crude drug 9g/10ml, by inventor, provided; Metformin hydrochloride (Shanghai Fahrenheit pharmacy).

1.1.2 animal Kunming mouse is 96, male and female half and half, and body weight (22.5 ± 2.5) g, provides by Shandong University's zoopery center.

1.1.3 reagent and instrument Streptozotocin (STZ) (SERVER company), purchased from magnificent company.Electronic balance AB204-WO type (Switzerland plum Teller-Tuo Co., Ltd); Hitachi's 7150 type automatic clinical chemistry analyzers (Japan).

1.2 method

1.2.1 modeling and grouping

Diabetes: animal is bought back, adaptability was fed after 1 week, be divided at random 40 of 8 of normal non-diabetic groups and experimental group, experimental group fasting 12 hours before modeling, modeling adopts the injection of STZ55mg/kg disposable celiac, within after administration 24 hours, survey blood sugar, glucose in urine, for three days on end, glucose in urine is qualitative +++ more than, blood glucose value surpasses 16.5mmol/L, and continue constant person, be defined as diabetes and form.Modeling success mouse is divided into 5 groups, model control group, melbine group, the high, medium and low concentration group of decocting liquid of the present invention at random.

Hyperlipidemia: animal is bought back, adaptability was fed after 1 week, be divided at random 40 of 8 of normal non-hyperlipidemia groups and experimental group, experimental group fasting 12 hours before modeling, modeling gives 1 week above 1% cholesterol that contains, the high lipoprotein emulsion of 20% lard, 2% sodium taurocholate, 1% propylthio pyrimidine, every day 1 time, continuous 7 days.Modeling success mouse is divided into 5 groups, model control group, melbine group, the high, medium and low concentration group of leaves of Hawthorn decocting liquid of the present invention at random.

1.2.2 administration and assay method Normal group and model control group (the isopyknic physiological saline of ig); Metformin hydrochloride group (ig, 0.20g/kg); Decocting liquid group of the present invention (difference ig every day decocting liquid 2.0g/kg of the present invention, 3.0g/kg, 4.0g/kg).Each group is gastric infusion respectively, and 1 time/d, continuous 30 days.12h fasting before last administration, 2h after administration, plucks eye and gets blood, with automatic clinical chemistry analyzer, measures blood sugar and blood fat.

1.2.3 all data of statistical procedures represent with " χ ± S ", SPSS11.5 statistical software analyzing and processing for data acquisition, if comparison homogeneity of variance One-way ANOVA between many groups, if heterogeneity of variance rank test is relatively used paired t-test before and after group is interior.

2 results

2.1 hypoglycemic experiments

As shown in Table 1, the high, medium and low concentration group of decocting liquid of the present invention all can significantly reduce the blood sugar of hyperglycaemia mouse model, and with model control group comparison, difference has statistical significance (P < 0.05).

2.3 lipopenicillinase experiment as shown in Table 2, the high, medium and low concentration of decocting liquid of the present invention all can obviously reduce TC, the TG content of hyperlipemia mice model, with model control group comparison, difference has statistical significance (P < 0.05, P < 0.01).

Table 1 liquid of the present invention is on the impact of mouse blood sugar (χ ± S)

Note: with Normal group comparison, Δ Δ P < 0.01; With model control group comparison, * P < 0.05, * * P < 0.01; NS, physiological saline.

Table 2 decocting liquid of the present invention is on the impact of lipid of mice (χ ± S)

3, microcirculation experimental technique:

3.1. materials and methods: get 50 mouse, be divided at random 5 groups, 10 every group (male and female half and half), the every mouse auris dextra of control group be coated with physiological saline a little; The every mouse auris dextra of positive controls is trained first blood-activating analgesic plaster, and test component is dosage group 600mg/kg/h in low dose group 400mg/kg/h of the present invention, the present invention, high dose 800mg/kg/h of the present invention.15min pneumoretroperitoneum is injected 0.1% yellow Jackets 0.1ml/10g anesthetized animal, and tail vein injection 0.1% adrenaline 0.1mL/10g, observes mouse right ear fine motion vein bore (μ m) and 0.2mm immediately subsequently ²experimental data is processed in capillary net number .t check.

3.2 results and discussion

3.2.1. on microcirculatory impact

Table 1, the impact of the present invention on the open number of mouse fine motion, vein bore and capillary

Compare with control group, the tested group of open number of 1 pair of mouse capillary has showed increased (P < 0.01); The open number of tested group of 2 pairs of venule bore and capillary has remarkable increase (P < 0.01); The tested group of open number of 3 pairs of mouse fine motions, vein bore and capillary all has increase (P < 0.01); Illustrate and be subject to reagent can improve microcirculation, have function of promoting blood circulation to disperse blood clots (table 1).

4, discuss

In recent years, along with improving constantly of people's living standard, the disease incidences such as diabetes, coronary heart disease increase day by day.Chinese herbal medicine effect is stable, few side effects, and research has the Chinese herbal medicine of hypoglycemic lipid-lowering effect, can be for treating clinically diabetes, hyperlipidemia provides more method.The fruit of glossy privet: the fruit of glossy privet contains a large amount of oleanolic acids, can accelerate the mobility of platelet cell, weakened the collision between blood platelet, make it to be difficult for adhesion and gathering, more difficultly at endangium, deposit, slow down or prevent thrombosis, can reduce again the deposition of lipid inner membrance, for preventing and treating the elderly's thrombotic diseases, providing part experimental basis.The fruit of glossy privet has significant immunological enhancement, thereby it is anti-ageing to remove free radical.That fruit of glossy privet flavones has is hypotensive, reduce peripheral vascular resistance, coronary artery dilator, increase coronary flow, reduce MCO, cardiac stimulant, increase cardiac output, resist myocardial ischemia, and platelet aggregation-against, improves hemorheological property, eliminates oxygen radical, falls the pharmacological actions such as excellent and constitution, enhancing hypoxia-bearing capability and diuresis.Clinical is all safe and effective for preventing and treating coronary disease and angina pectoris, hypertension, arrhythmia cordis and hyperlipidemia, atherosclerotic etc., is worthy of popularization.Particularly Resources of The West Area In China is very abundant in China various places for the fruit of glossy privet, has very high exploitation to be worth.Multiplex its treatment diabete of ancients, is equivalent to the diabetes in modern medicine.This experiment is established for verifying its hypoglycemic, effect for reducing fat, found that it truly has obvious hypoglycemic, effect for reducing fat.

Claims

1. a fruit of glossy privet hypertension and hyperlipemia health protection tea, it is characterized in that, in described fruit of glossy privet hypertension and hyperlipemia health protection tea, the parts by weight of various raw materials comprise: 10～50 parts of the fruit of glossy privets, 10～20 parts of hawthorn, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of elscholtizas, 10～20 parts of sealworts, 10～20 parts, the dried rhizome of rehmannia, 10～20 parts of cassia seeds, 10～20 parts of cogongrass rhizomes, 10～20 parts, Poria cocos, 10～20 parts of the reds sage root, 10～20 parts of Radix Codonopsis, 10～20 parts of roots of Chinese trichosanthes, 10～20 parts of gynostemma pentaphylla, 10～20 parts of the root barks of white mulberry, 10～20 parts of dried orange peels, 10～20 parts of the Radixs Astragali, 10～20 parts of Inula britannica chinensis, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts of the root barks of Chinese wolf-berry.

2. fruit of glossy privet hypertension and hyperlipemia health protection tea according to claim 1, it is characterized in that, in described fruit of glossy privet hypertension and hyperlipemia health protection tea, the parts by weight of various raw materials comprise: 10～30 parts of the fruit of glossy privets, 10～15 parts of hawthorn, 10～15 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～15 parts of elscholtizas, 10～15 parts of sealworts, 10～15 parts, the dried rhizome of rehmannia, 10～15 parts of cassia seeds, 10～15 parts of cogongrass rhizomes, 10～15 parts, Poria cocos, 10～15 parts of the reds sage root, 10～20 parts of Radix Codonopsis, 10～20 parts of roots of Chinese trichosanthes, 10～20 parts of gynostemma pentaphylla, 10～20 parts of the root barks of white mulberry, 10～20 parts of dried orange peels, 10～20 parts of the Radixs Astragali, 10～20 parts of Inula britannica chinensis, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts of the root barks of Chinese wolf-berry.

3. fruit of glossy privet hypertension and hyperlipemia health protection tea according to claim 1, it is characterized in that, in described fruit of glossy privet hypertension and hyperlipemia health protection tea, the parts by weight of various raw materials comprise: 10～40 parts of the fruit of glossy privets, 10～20 parts of hawthorn, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of elscholtizas, 10～20 parts of sealworts, 10～20 parts, the dried rhizome of rehmannia, 10～20 parts of cassia seeds, 10～20 parts of cogongrass rhizomes, 10～20 parts, Poria cocos, 10～20 parts of the reds sage root, 10～15 parts of Radix Codonopsis, 10～15 parts of roots of Chinese trichosanthes, 10～15 parts of gynostemma pentaphylla, 10～15 parts of the root barks of white mulberry, 10～15 parts of dried orange peels, 10～15 parts of the Radixs Astragali, 10～15 parts of Inula britannica chinensis, 10～15 parts of the bighead atractylodes rhizomes, 10～15 parts of the root barks of Chinese wolf-berry.

4. a preparation method for fruit of glossy privet hypertension and hyperlipemia health protection tea as described in claim 1～3 any one, is characterized in that, the preparation process of described fruit of glossy privet hypertension and hyperlipemia health protection tea comprises following aspect:

A. the preparation of the fruit of glossy privet;

5. the preparation method of fruit of glossy privet hypertension and hyperlipemia health protection tea according to claim 4, is characterized in that, in described step a, while having white powder in annual fruit of glossy privet fruit blackening in December, lays, and removes stalk, leaf and impurity, dries or puts in hot water and scald and dry later; Then steeping in wine is one, steams and thoroughly dries, standby.

6. the preparation method of fruit of glossy privet hypertension and hyperlipemia health protection tea according to claim 4, is characterized in that, in described step b, get in the ethanol that raw material adds 5-10 doubly to measure and soak 1-2 hour, heating is extracted 2 times, and each 1-2 hour, removes supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, 1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 ℃, heating is concentrated into paste, stand for standby use.

7. the preparation method of fruit of glossy privet hypertension and hyperlipemia health protection tea according to claim 4, it is characterized in that, in described step c, the filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator, the concentrate that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, then adds dextrin and puts into granulator and granulate.

8. treat according to claim 4 the preparation method of fruit of glossy privet hypertension and hyperlipemia health protection tea, it is characterized in that, in described steps d, the particle that the fruit of glossy privet preparing is prepared with surplus stock mixes, and ultraviolet disinfection is packed and be get final product.

9. the preparation method of basis fruit of glossy privet hypertension and hyperlipemia health protection tea as described in claim 1～3 any one, it is characterized in that, the process for producing granula of described fruit of glossy privet hypertension and hyperlipemia health protection tea can also be: all the other former parisons are entered to ethanol, heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged standing; Above-mentioned two kinds of extracts are merged, and decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 ℃ 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, and the medicinal extract that temperature to 60 is ℃-70 ℃, puts into oven drying and obtain powder, adds dextrin and granulates.

10. the preparation method of basis fruit of glossy privet hypertension and hyperlipemia health protection tea as described in claim 1～3 any one, it is characterized in that, the paste preparation method of described fruit of glossy privet hypertension and hyperlipemia health protection tea can be: other raw materials are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, and 100-120 order filters, then through the molecular weight that dams, is the ultrafiltration post ultrafiltration of 5000-10000,1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 ℃, heating is concentrated into paste.