CN103690816A - Traditional Chinese medicinal composition for eliminating spleen insufficiency, phlegm dampness and breast cystic hyperplasia and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for eliminating spleen insufficiency, phlegm dampness and breast cystic hyperplasia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for eliminating spleen insufficiency, phlegm dampness and breast cystic hyperplasia. The traditional Chinese medicinal composition is prepared from the following main raw materials by weight: 8 to 16 parts of Chinese angelica, 10 to 20 parts of bolbostemma paniculatum, 10 to 20 parts of hawthorn, 5 to 12 parts of fried rice sprout, 12 to 22 parts of pinellia ternate, 25 to 35 parts of spina gleditsiae, 15 to 30 parts of turtle shell, 25 to 35 parts of Tuckahoe, 25 to 35 parts of allium macrostemon, 30 to 40 parts of Asclepias curassarica, 30 to 40 parts of cowherb seed and 30 to 40 parts of safflower. The traditional Chinese medicine spray provided by the invention can effectively relieve stagnant qi and blood caused by spleen insufficiency, phlegm dampness and breast cystic hyperplasia, can relax the muscles and stimulate the blood circulation, also achieves the effect of invigorating spleen and kidney, achieves a good therapeutic effect on spleen insufficiency, phlegm dampness and breast cystic hyperplasia, and is a safe and effective traditional Chinese medicine spray for treating spleen insufficiency, phlegm dampness and breast cystic hyperplasia, without side effect.
Description
Technical field
The invention discloses a kind of Chinese medicine composition, especially a kind of Chinese medicine composition of eliminating insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast and preparation method thereof.The invention belongs to Chinese medicine field.
Background technology
Nodules of the breast (lump in breast), disease of tcm name, refers to the chronic benign lump that female breast portion is common, take lump in breast and distending pain as primary symptom, is common in young women.Nodules of the breast is found in the diseases such as the insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, Cystic hyperplasia of breast, mastofibroma of western medicine.Western medicine thinks that cyclomastopathy is relevant with ovarian dysfunction, and as lutein, secretion reduces, and estrogenic Secretion is to increasing.
Primary disease many with feelings will internal injury, be worried angry relevant.Stomach of foot Yang Ming is through breast, liver channel of foot-Jueyin to breast, outside the capable breast of spleen meridian, if feelings will internal injury, the angry liver spleen pent-up of being worried, QI and blood is disorderly contrary, the not all right Tianjin of gas, body fluid is condensed into expectorant; Multiple because of liver Wood restricts earth, cause spleen and can not transport wetly, stomach can not the turbid descending, the turbid interior life of expectorant; Stagnation of QI expectorant is turbid, and to hinder in newborn network be lump pain.Eight arteries and veins are subordinate in Liver and kidney, and chong channel is subordinate in sun bright, if pathogenic fire derived from stagnation of liver-QI, the moon of consume Liver and kidney, Chong and Ren channel disorder, < < Shengji Zonglu > > cloud: " rush wantonly two warps; be above milk, descending is moon water." so primary disease is many relevant to menstrual cycle.The basic pathogenesis of primary disease is that stagnation of QI expectorant is solidifying, and Chong and Ren channel disorder is sick at stomach, liver, spleen three warps.With breast, there is shape lump not of uniform size, pain, cystic hyperplasia of breast class disease for main manifestations relevant to menstrual cycle.
Primary disease is more common in 20～40 years old women, and show as one-sided or bilateral breast the single or multiple lumps that differ in size occur, distending pain or tenderness, smooth surface, clear border, pushes away movably, increasess slowly, strong but pliable in texture or be capsule sexuality.Double see lump and distending pain every because of the susceptible to anger elder that disappears, it is solidifying that card belongs to stagnation of QI expectorant; If often increase the weight of before menstruation comes, menstruation is alleviator later, is Chong and Ren channel disorder.Most have a flat lump at the outside upper quadrant of breast, and that lays one's hand on has a tough hard tubercle of beans size, can have tenderness, and owe clearly on lump border, with surrounding tissue adhesion.Breast can have distending pain or twinge, the often growth and decline with susceptible to anger, and month premenstrual increasing the weight of, alleviates after menstruation.
The Syndrome Types of TCM of nodules of the breast is a lot of, minute two types that have, and minute three types that have, until four types, five types, six types, seven types etc., even more.What have is excessively simple, and what have is too numerous.But always solidifying nothing more than stagnation of QI due to depression of the liver, stagnation of QI expectorant, blood stasis expectorant is solidifying, a discord, deficiency of spleen-YANG and kidneyYANG, the hepatic and renal YIN deficiency, QI and blood deficiency etc. are appointed in punching.Though the suggestion of each family is not the same, its pathogenesis all be unable to do without above-mentioned viewpoint.Doctor Li Jimin eliminates nodules of the breast (cyclomastopathy), and dialectical four types that are divided into are discussed and controlled clinically.
1. stagnation of QI due to depression of the liver: stagnation of liver-QI is not relaxed, breast distension, caking distending pain is with susceptible to anger growth and decline, time have twinge, two side of body distending pains, bitter taste is irritated, pale tongue with thin fur is white, stringy pulse or thin string.
2. Chong and Ren channel disorder: breast caking, dull pain or twinge, localized pain.Premenstrual lump obviously increases, through after reduce deliquescing, or companion menoxenia, dysmenorrhea, the disease such as infertile.Light red tongue tongue is white, and thready pulse moistens.
3. insufficiency of the spleen expectorant is solidifying: lump in breast is larger, but poor growth, the hard distending pain of matter, smooth surface, what push away can move, clear border, mammary contour is constant.Thin white fur of tongue, stringy and rolling pulse.
4. blood stasis due to renal deficiency: with the passing of time breast lumps, twinge or have a dull ache, sore spot is fixed.Companion's soreness of waist is weak, and through water is few, color is light, or amenorrhea, the disease such as infertile.There is petechia on the dark or tongue limit of tongue, white and thin fur, deep-thready pulse.
In the method for the insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast of existing elimination, application number is: 200510047163.6 patent discloses a kind of preparation method for the treatment of Chinese medicine and the coated tablet thereof of cystic hyperplasia of breast and mastitis, and it is by following raw materials in parts by weight, to count ratio to be prepared from: Cornu Cervi: Herba Taraxaci: Thallus Laminariae (Thallus Eckloniae): Radix Trichosanthis: Caulis Spatholobi: Radix Notoginseng: Radix Paeoniae Rubra: Sargassum: Radix Rhapontici: the Radix Aucklandiae: Radix Scrophulariae: Cortex Moutan: Spica Prunellae: Fructus Forsythiae: Flos Carthami=200-400: 100-300: 600-950: 40-120: 100-300: 100-300: 25-95: 260-480: 80-180: 90-240: 100-300: 180-380: 100-300: 40-120: 80-180.Medicine of the present invention is a kind of cystic hyperplasia of breast and effective Chinese medicine of mastitis for the treatment of, and it is dwindling lump in breast, and alleviating carbuncle of breast, bitterly to go up effect remarkable, it rapid-action, safe.Unsatisfactory for the effect of eliminating insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, can cause extra burden to patient's health.
Summary of the invention
Present situation for the insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast of existing elimination deficiency, one of object of the present invention is to provide a kind of Chinese medicine composition of eliminating insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, have easy to carry, action effect is obvious, the effect of playing blood circulation promoting and blood stasis dispelling that can be very fast, and it adopts comparatively common in the localities Chinese crude drug as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Eliminate the Chinese medicine composition of insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, take off the primary raw material of stating weight proportion and be prepared from: Radix Angelicae Sinensis 8-16 part, Rhizoma Bolbostematis 10-20 part, Fructus Crataegi 10-20 part, Fructus Setariae Germinatus (parched) 5-12 part, Rhizoma Pinelliae 12-22 part, Spina Gleditsiae 25-35 part, Carapax Trionycis 15-30 part, Poria 25-35 part, Bulbus Allii Macrostemonis 25-35 part, Herba asclepiadis curassaevicae 30-40 part, Semen Vaccariae 30-40 part Flos Carthami 30-40 part.
Foregoing Chinese medicine composition, preferred scheme is: take off the primary raw material of stating weight proportion and be prepared from: Radix Angelicae Sinensis 11-14 part, Rhizoma Bolbostematis 13-18 part, Fructus Crataegi 13-18 part, Fructus Setariae Germinatus (parched) 7-10 part, Rhizoma Pinelliae 16-18 part, Spina Gleditsiae 28-32 part, Carapax Trionycis 20-25 part, Poria 28-32 part, Bulbus Allii Macrostemonis 28-32 part, Herba asclepiadis curassaevicae 33-38 part, Semen Vaccariae 33-38 part Flos Carthami 33-38 part.
Foregoing Chinese medicine composition, the scheme being more preferably is: take off the primary raw material of stating weight proportion and be prepared from: 13 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Bolbostematiss, 15 parts of Fructus Crataegis, 9 parts of Fructus Setariae Germinatus (parched), 15 parts of the Rhizoma Pinelliaes, 30 parts of Spina Gleditsiaes, 22 parts of Carapax Trionycis, 30 parts, Poria, 30 parts of Bulbus Allii Macrostemonis, 35 parts of Herba asclepiadis curassaevicaes, 35 parts of 35 parts of Flos Carthami of Semen Vaccariae.
Before the preparation method of arbitrary described Chinese medicine composition, preferred scheme is that step is as follows:
1. slow fire for Rhizoma Bolbostematis, Fructus Crataegi, Spina Gleditsiae and Carapax Trionycis is fried to 5-15 minute, fry to give out dry in the air after fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Angelicae Sinensis, Fructus Setariae Germinatus (parched), the Rhizoma Pinelliae, Flos Carthami, Bulbus Allii Macrostemonis altogether pulverization cross 80-120 mesh sieve, must mix medicamental pulverata standby;
3. Poria, Herba asclepiadis curassaevicae and Semen Vaccariae are decocted with water 2 times, decoct for the first time 2 hours, filter, obtain filtrate 1, the filtering residue after filtering is added to water and decoct for the second time, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed and decocted 1-2 hour again with filtrate 2, standing 20-30 hour, again filter, obtain filtrate for later use;
4. by step 2. in gained mixings medicamental pulverata pour into step 3. in the filtrate of gained, mix homogeneously, the consumption of mixing medicamental pulverata is the 0.5-3% of filtrate weight, is aided with pharmaceutically acceptable carrier package and obtains.
Foregoing preparation method, preferred scheme is: step 1. slow fire is fried 8-13 minute (preferably 10 minutes).
Foregoing preparation method, preferred scheme is: 2. step crosses 90-110 mesh sieve (preferably 100 mesh sieves).
Foregoing preparation method, preferred scheme is: step 3. filtrate 1 is mixed with filtrate 2 and decocted 1.3-1.7 hour (preferably 1.5 hours) again.
Foregoing preparation method, preferred scheme is: step 3. standing 23-28 hour (preferably 25 hours).
Foregoing preparation method, preferred scheme is, the consumption that 4. step mixes medicamental pulverata is the 1-2% (preferably 1.5%) of filtrate weight.
The application of Chinese medicine composition described in the present invention also provides when the medicine of the insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast of preparation treatment, Cystic hyperplasia of breast, mastofibroma.
Using method: for making the present invention reach optimum therapeuticing effect, during use, first both hands and breast are cleaned up with warm water, Chinese medicine composition of the present invention is being sprayed on breast, with the hands 3 circles are respectively rubbed in left and right, one for several times, at every turn appropriate, within 7 days, is a course for the treatment of.
This Chinese medicine composition is remarkable to eliminating the effect of insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, not only spleen invigorating, can also blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons to promote blood circulation and QI and blood regulating, improve the slight illness that patient brings because of insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast for a long time, and Chinese medicine composition of the present invention, by the direct administration in affected part, can play the effect relieving the pain rapidly.
Eliminate a Chinese medicine composition for insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, the pharmacological effect of each crude drug is respectively:
Radix Angelicae Sinensis: sweet in the mouth; Pungent; Bitter; Warm in nature, return liver; The heart; Spleen channel, effect, enriches blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.
Cure mainly: all cards of blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.
Rhizoma Bolbostematis: hardship, cool.Eliminating stagnation poison, subduing inflammation.Control acute mastitis, scrofula sucutaneous nodule, sore swollen toxin and snakeworm poison.
Fructus Crataegi: acid is sweet, tepor.Help digestion long-pending, dissipating blood stasis blood, expelling tenia.Control meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia after-pains in puerperal, lochiorrhea, children's's breast food is stagnated.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, stomach alkane distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipidemia.
Fructus Setariae Germinatus (parched): Fructus Setariae Germinatus (parched) is a kind of concocting method of Fructus Setariae Germinatus, puts in pot and fries to buff the explosion of large portion with slow fire, and taking-up cools.Fructus Setariae Germinatus: sweet, flat.Return spleen, stomach warp.(1) promoting digestion and removing stagnation; Spleen benefiting and stimulating the appetite.For food stagnation, stagnate; Distension is had loose bowels; Insufficiency of the spleen few food; Beriberi edema.(2) help digestion and in, spleen benefiting and stimulating the appetite.For food stagnation, do not disappear, abdominal distention halitosis, weakness of the spleen and stomach, not hungry lack of appetite.Fructus Setariae Germinatus (parched) relatively helps digestion, for not hungry lack of appetite.The kind eliminate indigestion of Fructus Setariae Germinatus (parched to brown) is stagnant, for stagnant, does not disappear.
The Rhizoma Pinelliae: have another name called: the SANYE Rhizoma Pinelliae; First quarter moon lotus; Three steps are jumped; Ground eight beans; Medicine Canis familiaris L. red (Hebei); Keep field; Water is beautiful; Sheep eye; Bai Yang (boundary, Henan, Anhui one band); Fiber crops king fruit; Swallow tail; Ground literary composition.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness.Outer subduing inflammation., vomiting regurgitation dizzy for abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, interior expectorant, breast gastral cavity painful abdominal mass are vexed, globus hystericus disease; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.
Spina Gleditsiae: swollen ulcer drug, scrofula, skin ulcer rash stubborn dermatitis, puerperal hypogalactia, placenta retention, leprosy.
Carapax Trionycis: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea ， WEIJIA, chronic malaria malaria with splenomegaly.
Bulbus Allii Macrostemonis: acrid in the mouth; Bitter; Warm in nature.Cure mainly: the thorough back of the body of obstruction of qi in the chest and cardialgia; Breast gastral cavity painful abdominal mass is vexed; Cough with asthma abundant expectoration; Epigastric pain; After letting out dysentery, weigh; Leucorrhea; Furuncle carbuncle.
Semen Vaccariae: hardship, flat.Promoting the circulation of blood is stimulated the menstrual flow, and expedites the emergence of stimulating milk secretion, detumescence sore.Control women's amenorrhea, galactostasis, difficult labour, stranguria with blood, carbuncle, incised wound is hemorrhage.
Flos Carthami: irregular menstruation, puerperal abdonimal pain, lump in the abdomen, the disease such as traumatic stasis swells and ache, ulcer sore pain.
Herba asclepiadis curassaevicae: meridian distribution of property and flavor: hardship, cold.Function cures mainly: anti-inflammatory analgetic, hemostasis.For mastitis, carbuncle furuncle, dysmenorrhea; Fracture is controlled in external, knife injury, eczema, stubborn dermatitis.
Chinese medicine composition of the present invention is eliminated the principle of insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast based on Chinese medicine.The Chinese medicinal material of selecting all has blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons to promote blood circulation, and the effect of regulating the flow of Qi and the middle Jiao, and cheap, life-time service also can not cause patient's financial burden, is to eliminate the comparatively desirable medicine of insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not by this restriction.
embodiment 1eliminate a Chinese medicine composition for insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, take off the primary raw material of stating weight proportion (getting 10g for every part) and be prepared from: 8 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Bolbostematiss, 10 parts of Fructus Crataegis, 5 parts of Fructus Setariae Germinatus (parched), 12 parts of the Rhizoma Pinelliaes, 25 parts of Spina Gleditsiaes, 15 parts of Carapax Trionycis, 25 parts, Poria, 25 parts of Bulbus Allii Macrostemonis, 30 parts of Herba asclepiadis curassaevicaes, 30 parts of 30 parts of Flos Carthami of Semen Vaccariae.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. slow fire for Rhizoma Bolbostematis, Fructus Crataegi, Spina Gleditsiae and Carapax Trionycis is fried 5 minutes, fry to give out dry in the air after fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Angelicae Sinensis, Fructus Setariae Germinatus (parched), the Rhizoma Pinelliae, Flos Carthami, Bulbus Allii Macrostemonis altogether pulverization cross 80 mesh sieves, must mix medicamental pulverata standby;
3. Poria, Herba asclepiadis curassaevicae and Semen Vaccariae are decocted with water 2 times, decoct for the first time 2 hours, filter, obtain filtrate 1, the filtering residue after filtering is added to water and decoct for the second time, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed and decocted 1 hour again with filtrate 2, standing 20 hours, again filter, obtain filtrate for later use;
4. by step 2. in gained mixings medicamental pulverata pour into step 3. in the filtrate of gained, mix homogeneously, the consumption of mixing medicamental pulverata is 0.5% of filtrate weight, is aided with pharmaceutically acceptable carrier package and obtains.
typical case onepungent XX, female, 28 years old, Beijing personage, in August, 2011, patient examined, patient's readme while examining: first 5-7 days of each menstrual onset, breast distension pain, during menstrual onset, distending pain of the breast is alleviated to some extent, but pain does not disappear, by the time menstruation has not had later 5-7 days pain just can disappear, sometimes feel blue or when pressure is excessive, breast also has the phenomenon of distension pain, sometimes also mood is unhappy, to such an extent as to be unwilling to speak, usually fly into a rage, except above symptom, patient is myasthenia of limbs often also, be unwilling to walk, remove examination in hospital, be diagnosed as: insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, learn after Chinese medicine composition of the present invention that just 10 days before menstrual onset are brought into use.
After using the embodiment of the present invention 1 gained Chinese medicine composition, in menstrual onset fore udder pain, alleviate, see and produce effect and continue to use 4 courses for the treatment of of embodiment 1 gained Chinese medicine composition, by the time next menstrual onset fore udder pain disappears, the recovery from illness of patient's self-induction, after recovery from illness, use again Chinese medicine composition of the present invention to consolidate 2 courses for the treatment of, drug withdrawal is so far without recurrence.
embodiment 2eliminate a Chinese medicine composition for insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, take off the primary raw material of stating weight proportion (getting 20g for every part) and be prepared from: 16 parts of Radix Angelicae Sinensis, 20 parts of Rhizoma Bolbostematiss, 20 parts of Fructus Crataegis, 12 parts of Fructus Setariae Germinatus (parched), 22 parts of the Rhizoma Pinelliaes, 35 parts of Spina Gleditsiaes, 30 parts of Carapax Trionycis, 35 parts, Poria, 35 parts of Bulbus Allii Macrostemonis, 40 parts of Herba asclepiadis curassaevicaes, 40 parts of 40 parts of Flos Carthami of Semen Vaccariae.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. slow fire for Rhizoma Bolbostematis, Fructus Crataegi, Spina Gleditsiae and Carapax Trionycis is fried 15 minutes, fry to give out dry in the air after fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Angelicae Sinensis, Fructus Setariae Germinatus (parched), the Rhizoma Pinelliae, Flos Carthami, Bulbus Allii Macrostemonis altogether pulverization cross 120 mesh sieves, must mix medicamental pulverata standby;
3. Poria, Herba asclepiadis curassaevicae and Semen Vaccariae are decocted with water 2 times, decoct for the first time 2 hours, filter, obtain filtrate 1, the filtering residue after filtering is added to water and decoct for the second time, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed and decocted 2 hours again with filtrate 2, standing 30 hours, again filter, obtain filtrate for later use;
4. by step 2. in gained mixings medicamental pulverata pour into step 3. in the filtrate of gained, mix homogeneously, the consumption of mixing medicamental pulverata is 3% of filtrate weight, is aided with pharmaceutically acceptable carrier package and obtains.
typical case twolee XX, 26 years old, people from Changsha, the worker of certain factory, examine in May, 2012, while examining patient's readme spiritual gloomy closely over the past half year, susceptible to lose temper due to restlessness.Before four months, accidentally sensation bimastism has lump, both sides distending pain of the breast between month paramenstrum, occasionally have sharply, and lump in breast increases with the fluctuation of breast feelings will, and spirit is gloomy, sensation of oppression over the chest with shortness of breath, be diagnosed as on inspection " cystic cyclomastopathy ", in outer court treatment, clothes " RUPIXIAO, RUHE SANJIE PIAN " and symptom does not subtract and examine.Doctor only listens that patient is oral cannot be confirmed to be what reason causes, through the inspection of science, find: grow normally, can touch cystic mass as large in egg on bilateral breast, soft, movable, the with no pressure pain of matter, color of the leather are constant, without adhesion, nipple is without abnormal secretions with chest; Pale tongue with white fur, thready and stringy pulse.Be diagnosed as: the Cystic hyperplasia of breast that insufficiency of the spleen phlegm-damp causes, because patient requires expectant treatment, so doctor advised is used Chinese medicine composition of the present invention.
Use the embodiment of the present invention 2 gained Chinese medicine composition after 1 course for the treatment of symptom start to alleviate, face makes moderate progress, the symptom of breast distension and twinge alleviates to some extent, lump diminishes, while using after 4 courses for the treatment of, patient's self-induction symptom disappears substantially, after recovery from illness, use again Chinese medicine composition of the present invention to consolidate 1 course for the treatment of, drug withdrawal is so far without recurrence.
embodiment 3eliminate a Chinese medicine composition for insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, take off the primary raw material of stating weight proportion (getting 30g for every part) and be prepared from: 11 parts of Radix Angelicae Sinensis, 13 parts of Rhizoma Bolbostematiss, 13 parts of Fructus Crataegis, 7 parts of Fructus Setariae Germinatus (parched), 16 parts of the Rhizoma Pinelliaes, 28 parts of Spina Gleditsiaes, 20 parts of Carapax Trionycis, 28 parts, Poria, 28 parts of Bulbus Allii Macrostemonis, 33 parts of Herba asclepiadis curassaevicaes, 33 parts of 33 parts of Flos Carthami of Semen Vaccariae.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. slow fire for Rhizoma Bolbostematis, Fructus Crataegi, Spina Gleditsiae and Carapax Trionycis is fried 8 minutes, fry to give out dry in the air after fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Angelicae Sinensis, Fructus Setariae Germinatus (parched), the Rhizoma Pinelliae, Flos Carthami, Bulbus Allii Macrostemonis altogether pulverization cross 90 mesh sieves, must mix medicamental pulverata standby;
3. Poria, Herba asclepiadis curassaevicae and Semen Vaccariae are decocted with water 2 times, decoct for the first time 2 hours, filter, obtain filtrate 1, the filtering residue after filtering is added to water and decoct for the second time, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed and decocted 1.3 hours again with filtrate 2, standing 23 hours, again filter, obtain filtrate for later use;
4. by step 2. in gained mixings medicamental pulverata pour into step 3. in the filtrate of gained, mix homogeneously, the consumption of mixing medicamental pulverata is 1% of filtrate weight, is aided with pharmaceutically acceptable carrier package and obtains.
embodiment 4eliminate a Chinese medicine composition for insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, take off the primary raw material of stating weight proportion (getting 40g for every part) and be prepared from: 14 parts of Radix Angelicae Sinensis, 18 parts of Rhizoma Bolbostematiss, 18 parts of Fructus Crataegis, 10 parts of Fructus Setariae Germinatus (parched), 18 parts of the Rhizoma Pinelliaes, 32 parts of Spina Gleditsiaes, 25 parts of Carapax Trionycis, 32 parts, Poria, 32 parts of Bulbus Allii Macrostemonis, 38 parts of Herba asclepiadis curassaevicaes, 38 parts of 38 parts of Flos Carthami of Semen Vaccariae.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. slow fire for Rhizoma Bolbostematis, Fructus Crataegi, Spina Gleditsiae and Carapax Trionycis is fried 13 minutes, fry to give out dry in the air after fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Angelicae Sinensis, Fructus Setariae Germinatus (parched), the Rhizoma Pinelliae, Flos Carthami, Bulbus Allii Macrostemonis altogether pulverization cross 110 mesh sieves, must mix medicamental pulverata standby;
3. Poria, Herba asclepiadis curassaevicae and Semen Vaccariae are decocted with water 2 times, decoct for the first time 2 hours, filter, obtain filtrate 1, the filtering residue after filtering is added to water and decoct for the second time, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed and decocted 1.7 hours again with filtrate 2, standing 28 hours, again filter, obtain filtrate for later use;
4. by step 2. in gained mixings medicamental pulverata pour into step 3. in the filtrate of gained, mix homogeneously, the consumption of mixing medicamental pulverata is 2% of filtrate weight, is aided with pharmaceutically acceptable carrier package and obtains.
typical case threelu XX, female, 30 years old, people from Yantai, Shandong, in January, 2013 morbidity, symptom: breast caking, dull pain or twinge, localized pain.Premenstrual lump obviously increases, through after reduce deliquescing, with menoxenia, dysmenorrhea etc. disease.Doctor watches patient's complexion jaundice obfuscation, and light red tongue tongue is white, and whether doctor inquires soreness of the waist and knees, the premenstrual soreness of waist of patient's readme is weak, through water is few, color is light, through doctor, is diagnosed as the Cystic hyperplasia of breast that insufficiency of the spleen phlegm-damp causes, and brings into use Chinese medicine composition of the present invention under doctor's suggestion.
Use the embodiment of the present invention 4 resulting composition after 2 courses for the treatment of, malaise symptoms disappears substantially, and patient feels recovery from illness, uses again the present composition after 2 courses for the treatment of after recovery from illness, so far without recurrence.
embodiment 5eliminate a Chinese medicine composition for insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, take off the primary raw material of stating weight proportion (getting 50g for every part) and be prepared from: 13 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Bolbostematiss, 15 parts of Fructus Crataegis, 9 parts of Fructus Setariae Germinatus (parched), 15 parts of the Rhizoma Pinelliaes, 30 parts of Spina Gleditsiaes, 22 parts of Carapax Trionycis, 30 parts, Poria, 30 parts of Bulbus Allii Macrostemonis, 35 parts of Herba asclepiadis curassaevicaes, 35 parts of 35 parts of Flos Carthami of Semen Vaccariae.
The preparation method of above-mentioned Chinese medicine composition, step is:
1. slow fire for Rhizoma Bolbostematis, Fructus Crataegi, Spina Gleditsiae and Carapax Trionycis is fried 10 minutes, fry to give out dry in the air after fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Angelicae Sinensis, Fructus Setariae Germinatus (parched), the Rhizoma Pinelliae, Flos Carthami, Bulbus Allii Macrostemonis altogether pulverization cross 100 mesh sieves, must mix medicamental pulverata standby;
3. Poria, Herba asclepiadis curassaevicae and Semen Vaccariae are decocted with water 2 times, decoct for the first time 2 hours, filter, obtain filtrate 1, the filtering residue after filtering is added to water and decoct for the second time, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed and decocted 1.5 hours again with filtrate 2, standing 25 hours, again filter, obtain filtrate for later use;
4. by step 2. in gained mixings medicamental pulverata pour into step 3. in the filtrate of gained, mix homogeneously, the consumption of mixing medicamental pulverata is 2% of filtrate weight, is aided with pharmaceutically acceptable carrier package and obtains.
experimental examplein order to verify whether this Chinese medicine composition (embodiment 5) has curative effect to eliminating insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, the < < new Chinese medicine guideline of clinical investigations > > formulating for 1993 according to Ministry of Public Health is diagnosis basis, totally 200 routine insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast patients, the mean age is 30 years old.Random division is administration group and matched group.Before experiment one day, records patient's health, looks over patient body symptom every day, guarantees that administration group and matched group situation are basically identical.Administration group is used this product embodiments 5 gained Chinese medicine compositions every day, during use, first both hands and breast is cleaned up with warm water, Chinese medicine composition of the present invention is being sprayed on breast, and with the hands 3 circles are respectively rubbed, 3 times on the one in left and right, 2 grams of each sprays 7 days are a course for the treatment of.Experimental group is taken or is used other medicines of eliminating insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast (as the medicine of the insufficiency of the spleen phlegm-damp Cystic hyperplasia of breasts of routine elimination such as RUPIXIAO capsule, nodules of the breast relieving capsule and nodules of the breast cream) to check every day and makes a record patient body situation.Criterion, cures: malaise symptoms disappears, effectively: malaise symptoms disappears substantially, invalid: malaise symptoms is unchanged.Result is as following table 1:
Table 1:
efficacy analysis:when administration group (Chinese medicine composition of the present invention) is used 7 days, most patient sensory symptoms obviously alleviates, and obviously feels to take a favorable turn in affected part, and patient's emotion takes a turn for the better, medication in the time of 14 days patient be almost recovered, drug withdrawal a period of time has no repeatedly, the state of an illness is better controlled.Matched group take medicine after curative effect obvious, but after drug withdrawal, 94% patient is recurred again.
Through clinical trial, prove, Chinese medicine composition of the present invention is being eliminated on insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, effective percentage is 98%, cure rate is 95%, than the oral medicine effective percentage that other eliminate insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, exceed 18%, cure rate exceeds 25%, and can thoroughly remove old complaint, makes the real recovery from illness of patient; And can not cause any burden to patient's health.Chinese medicine composition instant effect of the present invention, can reach the object of rapid alleviation patient misery, and relapse rate is low, is a kind of Chinese medicine composition of eliminating safely and effectively insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast.
Claims (10)
1. the Chinese medicine composition of eliminating insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast, is characterized in that: take off the primary raw material of stating weight proportion and be prepared from: Radix Angelicae Sinensis 8-16 part, Rhizoma Bolbostematis 10-20 part, Fructus Crataegi 10-20 part, Fructus Setariae Germinatus (parched) 5-12 part, Rhizoma Pinelliae 12-22 part, Spina Gleditsiae 25-35 part, Carapax Trionycis 15-30 part, Poria 25-35 part, Bulbus Allii Macrostemonis 25-35 part, Herba asclepiadis curassaevicae 30-40 part, Semen Vaccariae 30-40 part Flos Carthami 30-40 part.
2. Chinese medicine composition according to claim 1, is characterized in that: take off the primary raw material of stating weight proportion and be prepared from: Radix Angelicae Sinensis 11-14 part, Rhizoma Bolbostematis 13-18 part, Fructus Crataegi 13-18 part, Fructus Setariae Germinatus (parched) 7-10 part, Rhizoma Pinelliae 16-18 part, Spina Gleditsiae 28-32 part, Carapax Trionycis 20-25 part, Poria 28-32 part, Bulbus Allii Macrostemonis 28-32 part, Herba asclepiadis curassaevicae 33-38 part, Semen Vaccariae 33-38 part Flos Carthami 33-38 part.
3. Chinese medicine composition according to claim 1, is characterized in that: take off the primary raw material of stating weight proportion and be prepared from: 13 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Bolbostematiss, 15 parts of Fructus Crataegis, 9 parts of Fructus Setariae Germinatus (parched), 15 parts of the Rhizoma Pinelliaes, 30 parts of Spina Gleditsiaes, 22 parts of Carapax Trionycis, 30 parts, Poria, 30 parts of Bulbus Allii Macrostemonis, 35 parts of Herba asclepiadis curassaevicaes, 35 parts of 35 parts of Flos Carthami of Semen Vaccariae.
4. according to the preparation method of the arbitrary described Chinese medicine composition of claim 1-4, it is characterized in that, step is as follows:
1. slow fire for Rhizoma Bolbostematis, Fructus Crataegi, Spina Gleditsiae and Carapax Trionycis is fried to 5-15 minute, fry to give out dry in the air after fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Angelicae Sinensis, Fructus Setariae Germinatus (parched), the Rhizoma Pinelliae, Flos Carthami, Bulbus Allii Macrostemonis altogether pulverization cross 80-120 mesh sieve, must mix medicamental pulverata standby;
3. Poria, Herba asclepiadis curassaevicae and Semen Vaccariae are decocted with water 2 times, decoct for the first time 2 hours, filter, obtain filtrate 1, the filtering residue after filtering is added to water and decoct for the second time, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed and decocted 1-2 hour again with filtrate 2, standing 20-30 hour, again filter, obtain filtrate for later use;
4. by step 2. in gained mixings medicamental pulverata pour into step 3. in the filtrate of gained, mix homogeneously, the consumption of mixing medicamental pulverata is the 0.5-3% of filtrate weight, is aided with pharmaceutically acceptable carrier package and obtains.
5. preparation method according to claim 4, is characterized in that: step 1. slow fire is fried 8-13 minute (preferably 10 minutes).
6. preparation method according to claim 4, is characterized in that: 2. step crosses 90-110 mesh sieve (preferably 100 mesh sieves).
7. preparation method according to claim 4, is characterized in that: step 3. filtrate 1 is mixed with filtrate 2 and decocted 1.3-1.7 hour (preferably 1.5 hours) again.
8. preparation method according to claim 4, is characterized in that: step 3. standing 23-28 hour (preferably 25 hours).
9. according to the preparation method described in claim 1, it is characterized in that, the consumption that 4. step mixes medicamental pulverata is the 1-2% (preferably 1.5%) of filtrate weight.
10. the application of the Chinese medicine composition as described in as arbitrary in claim 1-3 when the medicine of the insufficiency of the spleen phlegm-damp Cystic hyperplasia of breast of preparation treatment, cyclomastopathy, mastofibroma.
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