CN103635218B

CN103635218B - intranasal delivery device

Info

Publication number: CN103635218B
Application number: CN201280016126.7A
Authority: CN
Inventors: 筒井达雄
Original assignee: Translational Research Ltd
Current assignee: Translational Research Ltd
Priority date: 2011-01-31
Filing date: 2012-01-31
Publication date: 2016-11-30
Anticipated expiration: 2032-01-31

Abstract

Provide the device for delivering dried powder preparation.Device can be single use device.Provide preparation and the manufacture method of dry powder compositions for being suitable for intranasal administration.Additionally provide for prevention or control vomiting and other diseases and the using method of disorder and for treating the device of preparation intranasal delivery, compositions and method.

Description

Intranasal delivery device

Technical field

Priority

Merge with way of reference

This application claims the priority of the U.S. Provisional Patent Application No. 61/437,994 submitted on January 31st, 2011, its It is incorporated by reference herein.The complete disclosure mentioned in this manual and patent application are incorporated by reference this Literary composition, as each single disclosure or patent application specifically and are expressed as being incorporated by reference seriatim.

Background technology

Background of invention

Lead to the nostril of experimenter (such as patient) and/or the apparatus and method of nasal cavity for delivering powdered treatment preparation Being often known, including being described in U.S. Patent No. 7,278,982 and 7, the apparatus and method in 438,700, it is all interior Hold and be herein incorporated with way of reference.The existing apparatus and method for delivering powdered treatment preparation can have one or more Defect, such as, recycling intranasal delivery device may require that periodically cleaning and maintenance prevent from polluting and guaranteeing good hygiene With correct operation.Additionally, intranasal delivery device can cannot deliver continuously or repeated doses, or cannot deliver substantially all of Dosage.User is caused burden by the size of intranasal delivery device and weight when carrying device, or intranasal delivery is filled Put when holding or use the most awkward.Methods described herein and device can solve these and other problems, thus for patient or accompany The person of protecting provides simple and carrys out intranasal administration powdered treatment preparation with more easily mode.

Quote list of documents

Patent documentation

[patent documentation 1] U.S. Patent number 7,278,982

[patent documentation 2] U.S. Patent number 7,438,700

Summary of the invention

One aspect of the present invention provides a kind of device, comprises: described nozzle a) can be made to position at least partially to tested The nozzle with upstream extremity and downstream in the nostril of person；B) storage chamber of single dose powdered treatment preparation, described storage are comprised Room has upstream extremity and downstream and is placed in described nozzle；C) there is the valve of upstream extremity and downstream, wherein said valve The primary importance that is suitable in occupying device of door and the second position, and wherein said valve is suitable for when device is activated drawing Play the diffusion of powdered treatment preparation；D) being operably connected to the air source of valve downstream end, wherein said device is once Property use device.In one embodiment, valve is suitable for after air source is activated producing eddy airstream in storage chamber.? In another embodiment, valve is suitable for after air source is activated allowing whole walls of storage chamber to be covered by air-flow.At another Planting in embodiment, valve is at least partially disposed in nozzle.In another embodiment, powdered treatment preparation be positioned at along Nozzle inner walls and between valve and inwall.In another embodiment, valve is adapted to after air source is activated The powdered treatment preparation that littleization remains between valve and nozzle inner walls.In another embodiment, device is suitable for passing Send the single dose powdered treatment preparation of 80% to 99% in the nostril of experimenter.In another embodiment, device It is suitable for after single actuation air source the single dose powdered treatment preparation delivering 80% to 99% in experimenter nostril. In another embodiment, air source comprises flow export.In another embodiment, valve is suitable for when device does not swash The movement by flow export of the powdered treatment preparation is stoped when living.In another embodiment, valve is suitable for when device swashs The movement by flow export of the powdered treatment preparation is stoped when living.In another embodiment, the valve when device does not activate Cover flow export.In another embodiment, when device activates, valve does not cover flow export.In another embodiment, valve Door comprises the tip portion being connected to the first cylindrical portion, and the first cylindrical portion is connected to the first shelf, with And first shelf be connected to the second cylindrical portion.

In another embodiment, tip portion comprises coniform shape.In another embodiment, first shelf Surface comprises at least one slit.In another embodiment, the first shelf comprises at least one slit.Implement at another kind In mode, the first shelf comprises about 1 to 50 slit.In another embodiment, the first shelf comprises about 1 to 20 Individual slit.In another embodiment, the first shelf comprises about 1 to 10 slit.In another embodiment, described At least one slit and the first shelf edge become 45 degree of angles.In another embodiment, at least one slit described works as air It is adapted for when source is activated allowing air to flow to nozzle from air source.In another embodiment, nozzle comprises blast tube.? In another embodiment, valve is that part is positioned at blast tube.In another embodiment, the tip portion and of valve One cylindrical portion is positioned at blast tube.In another embodiment, the second cylindrical portion of valve is not located at nozzle In pipe.

In another embodiment, the first shelf contact nozzle pipe when air source is activated.Another kind of embodiment party In formula, air source is suitable for carrying the air of 2 to 7mL.In another embodiment, device be suitable for delivering 1 to 50mg it Between powdered treatment agent.In another embodiment, device volume is less than 50cm³.In another embodiment, device Quality less than 20 grams.In another embodiment, air source is suitable for being activated by user, forces air from air source warp Cross flow export, surface along at least one slit of the first shelf enters storage chamber, and goes out from the downstream of nozzle.Separately In a kind of embodiment, device is suitable for providing laminar air flow at least partially in storage chamber when the device is in use.At another kind In embodiment, air source comprises pump.In another embodiment, device is adapted to pass through and uses about 5 to about to pump Powdered treatment compositions is delivered in the nostril of experimenter after the compression stress of 30 kPas.In another embodiment, Described pump comprises the deformable volume being suitable for being activated by a user further.In another embodiment, pump comprises manual sky Air pump.In another embodiment, described manual air pump is suitable for being by a user in thumb and forefinger, middle finger, the third finger, little Activated by extrusion pump between thumb or a combination thereof.In another embodiment, the internal diameter that storage chamber comprises is less than 10mm. In another embodiment, what nozzle comprised 5mm to 20mm further is perpendicular to upstream to the length of downstream shaft.At another kind In embodiment, what nozzle comprised 5mm to 40mm further is parallel to upstream to the length of downstream shaft.

In another embodiment, air source comprises air flow inlet further, and wherein said inflow entrance is less than flowing out The 10% of mouth size.In another embodiment, a diameter of 0.1 to 2mm of described inflow entrance.In another embodiment In, nozzle comprises further and is positioned at the upstream extremity of nozzle and is suitable to stop the airtight of extraneous air contact powdered treatment preparation Cap.In another embodiment, described nozzle also includes that one is positioned at nozzle downstream and is suitable for stoping air-flow by spray The removable of mouth maybe can crush lid.In another embodiment, the downstream of nozzle comprises nozzle bore further.

In another embodiment, valve is adapted to provide for along at least one of laminar air flow of storage chamber.At another In kind of embodiment, valve is suitable for moving to the second position from primary importance, wherein in described primary importance, upstream face with Flow export connects, thus blocks the air draught flowing into storage chamber, and flows into the air draught of storage chamber in the described second position It is to allow.In another embodiment, the compression stress being at least 20 kPas by being applied to air source produces and fills The air draught of foot.In another embodiment, nozzle is made up of substantial transparent or translucent material.Real at another kind Executing in mode, nozzle comprises the screw thread (thread) being suitable for nozzle is fixed to air source further.

Another aspect of the present invention provides the method using device to deliver powdered treatment preparation, wherein said method The nozzle comprising location equipment is to the nostril of experimenter and activates air source, and wherein said device is disposable dress Putting, comprise: a) have the nozzle of upstream extremity and downstream, described nozzle is adapted to allow at least some of location of described nozzle Nostril to experimenter；B) storage chamber, the powdered treatment preparation comprising doses and there is upstream extremity and downstream, can grasp It is connected to and is arranged in described nozzle with making；C) having the valve of upstream extremity and downstream, wherein said valve is suitable for accounting for According to the primary importance in device and the second position, and wherein said valve is suitable for when device activates causing powdered treatment The diffusion of preparation；D) being operably connected to the air source of valve downstream end, wherein said device is single use device.? In a kind of embodiment, the nozzle of device and storage chamber comprise transparent or semitransparent material and wherein said method comprises further Visual inspection powdered treatment preparation surplus in storage chamber and repeat described method until enough dosage is delivered.? In a kind of embodiment, described method comprises further and is moved to second from primary importance by described valve when a device is activated Position.In another embodiment, described method comprises activation air source further to produce at least along storage chamber The laminar air flow divided.In another embodiment, method further comprise deliver 1mg to 50mg powdered treatment preparation arrive The nostril of experimenter.In another embodiment, method also includes the single dose powdered treatment system of 80% to 99% Agent is delivered in experimenter nostril.In another embodiment, described method comprises the power with 5 to 30 kPas further Compression manual air pump.In another embodiment, described method is positioned to the nose of experimenter further contained in nozzle From nozzle removing caps before in hole.

Another aspect of the present invention relates to manufacturing for delivering the powdered treatment preparation method to the device of experimenter, Wherein said method comprises: powdered treatment preparation provides storage chamber and nozzle is connected to air source, Qi Zhongsuo subsequently Stating device to comprise: a) have the nozzle of upstream extremity and downstream, described nozzle is adapted to allow at least some of of described nozzle Navigate to the nostril of experimenter；B) storage chamber, the powdered treatment preparation comprising doses and there is upstream extremity and downstream, It is operably connected to and is arranged in described nozzle；C) having the valve of upstream extremity and downstream, wherein said valve is suitable for Primary importance in occupying device and the second position, and wherein said valve is suitable for when device activates causing powder The diffusion for the treatment of preparation；D) air source of valve downstream end it is operably connected to.

In one embodiment, when the removable cover being positioned at described nozzle downstream is not removed, described Device does not comprise air flow inlet.In one embodiment, when removable maybe can crush lid be not removed time, powdered treatment The storage chamber of preparation is the system closed, thus the stability of powdered treatment preparation in improve storage chamber.At a kind of embodiment In, when the removable cover being positioned at described nozzle downstream is removed, described device comprises air flow inlet.A kind of embodiment party In formula, nozzle downstream comprises nozzle bore further and described nozzle bore comprises air flow inlet.

In some embodiments, described valve comprises interior inlet part and described interior inlet is attached partially to One cylindrical portion, and the first cylindrical portion is connected to the first shelf, and the first shelf to be connected to second cylindric Part.In one embodiment, described valve also comprises interior inlet part and described interior inlet is attached partially to top End portion.In one embodiment, described valve comprises valve pocket.In one embodiment, described valve pocket comprises and is positioned at valve The chamber of the hollow in Men, the opening at described valve pocket upstream extremity, the opening of described valve pocket downstream end.At a kind of embodiment In, described valve pocket crosses over the whole length of described valve.In one embodiment, the opening quilt of valve pocket and valve pocket downstream end It is connected to the opening at storage chamber, and valve pocket upstream extremity and is connected to air source.

In one embodiment, when pump is activated, all air in pump enter storage chamber, thus increase powder The delivery for the treatment of preparation.

Accompanying drawing explanation

Described novel feature is specifically illustrated by appended claims.By with reference to following to make use of device, The specific descriptions of the illustrative embodiments of the principle of method and composition, and appended accompanying drawing may be better understood this Bright feature and benefit, in accompanying drawing:

[Fig. 1] Fig. 1 illustrates the sectional view of intranasal delivery device described herein.The lid (134) that can crush is permissible It it is removable lid.

[Fig. 2] Fig. 2 i-2vi illustrates the different views of the check valve in intranasal delivery device.

[Fig. 3] Fig. 3 illustrates the method using the intranasal delivery device shown in Fig. 1.The lid (134) that can crush is permissible It it is removable lid.

[Fig. 4] Fig. 4 illustrates outside drawing (left) and the sectional view (right) of intranasal delivery device as herein described and check valve. The lid (430) that can crush can be removable lid.

[Fig. 5] Fig. 5 illustrates the enlarged drawing of the check valve of the intranasal delivery device described in Fig. 4.

[Fig. 6] Fig. 6 illustrates the enlarged drawing of a kind of embodiment of the device shown in Fig. 1.A square frame in figure is dashed forward Go out is the powdered treatment preparation along nozzle (Y) interior wall.Highlight in another frame in figure is nozzle inner walls and list Powdery shape treatment preparation between valve (Z).

[Fig. 7 A] Fig. 7 A and 7B illustrates when the slit on first shelf (730) of check valve (700) is aclinal (figure 7A, 740) and when slit is to tilt (Fig. 7 B, 750), flow to along nozzle inner walls and the air along check valve (700) surface The difference entered.

[Fig. 7 B] Fig. 7 A and 7B illustrates when the slit on first shelf (730) of check valve (700) is aclinal (figure 7A, 740) and when slit is to tilt (Fig. 7 B, 750), flow to along nozzle inner walls and the air along check valve (700) surface The difference entered.

[Fig. 8] Fig. 8 A and Fig. 8 B show when slit on the first shelf (830) be aclinal (Fig. 8 A, 840) and When slit is to tilt (Fig. 8 B, 850), the difference that the air stream along check valve (800) enters.

[Fig. 8 B] Fig. 8 A and Fig. 8 B show when slit on the first shelf (830) be aclinal (Fig. 8 A, 840) and When slit is to tilt (Fig. 8 B, 850), the difference that the air stream along check valve (800) enters.

[Fig. 9] Fig. 9 illustrates the sectional view of intranasal delivery device described herein.

[Figure 10] Figure 10 i-vi illustrates the different views of the check valve in intranasal delivery device.

[Figure 11] Figure 11 illustrates and uses the method for intranasal delivery device shown in Fig. 9.

Detailed description of the invention

Detailed Description Of The Invention

This application describes intranasal delivery device.Intranasal delivery device can be used for using powder to the people needing treatment and controls Treat preparation.Can be by medical professional and/or people (such as patient) the delivery powdered treatment preparation needing treatment.Such as this paper institute State, the powdered treatment preparation that device can be pre-loaded with being dried.Intranasal delivery device can be disposable device. Device described herein can have several part.Such as, device described herein can comprise three parts, such as, air source, nozzle and Check valve.Powdered treatment preparation be directed into the nozzle of device, and it can be as storage chamber.Nozzle can join with air source Connect.The novel feature of single use intranasal delivery device disclosed herein can be to exist can allow from device high speed rate Remove the check valve of powdered treatment preparation.Device described herein can deliver powdered treatment preparation completely so that device activates The amount of rear residue powdered treatment preparation in a device is minimum.Check valve can take the of this device when device is not activated One position and occupy the second position when device is activated.Check valve is suitable for when device is activated regulating from air source to spray The air-flow of mouth.Check valve is suitably adapted for stoping the powdered treatment preparation shifting of air source in device in device upstream storage chamber Dynamic.Check valve can comprise can be used in storage chamber produce eddy current it is thus possible to efficiently deliver powdered treatment preparation slit (ditch or groove).Slit in check valve can be positioned so that air-flow laminar flow in permission storage chamber.Slit in check valve can be positioned Become and produce swirl airflow when air source is activated.

I. device

Summary

Provided herein is the intranasal delivery device comprising nozzle, check valve and air or gas source.Described nozzle can be with sky Gas or gas source connect, and check valve can be placed in nozzle.In some embodiments, when check valve is in primary importance Time nozzle be not in fluid communication with air or gas source, when check valve is in the second position, nozzle and air or gas source fluid are even Logical.

Device described herein is by being more fully understood with reference to figures provided herein.Fig. 1 illustrates once Property the sectional view of intranasal delivery device that uses.It can be the sky of flexible bladder (102) that intranasal delivery device (100) can comprise Source of the gas.Described flexible bladder can be as manual air pump (104).Described flexible bladder can comprise inflow entrance (not shown) and Flow export (106).Optionally, described flexible bladder is not required to comprise inflow entrance.Described flexible bladder can comprise be positioned at soft Property bottle top have than flexible bladder (110) bottom more narrow diameter throat (108).Described throat (108) can comprise For connect nozzle (114) external screw thread (112).

Check valve (116) can be positioned at flexible bladder when not being activated when device (such as when hand air pump is uncompressed) (102) throat (108) surface also blocks flow export (106).Check valve (116) leans against the surface of throat (108) at device not Powdered treatment compositions (M) can be stoped when being activated to enter flexible bladder (102).

Check valve (116) can comprise tip portion (118), the first cylindrical portion (120), the first shelf (122), Two cylindrical portion (124) and the second shelf (126).One or more slits (128) can be on the first shelf surfaces.One Or multiple slit (128) can be allowed air or gas to flow from flexible bladder (102) when manual air pump (104) compress To nozzle (114) (see for example Fig. 3).The embodiment of check valve (116) is shown in Figure 2.

Intranasal device (100) can also comprise nozzle (114), and it can comprise and can be inserted into or be inserted partially into experimenter Nasal cavity or nostril in blast tube (130).Nozzle (114) can also comprise nozzle bore (132), removable maybe can crush lid And the storage chamber of powdered treatment preparation (138) (134).The storage chamber of powdered treatment preparation can comprise powdery treatment preparation (M).Described nozzle (114) can comprise bottom (140), and it can comprise for being connected to flexible bladder (102) throat (108) Female thread (142).The female thread of described nozzle bottom can match with the external screw thread of bottle throat.

Fig. 2 illustrates the different views of check valve (116) embodiment corresponding with check valve shown in Fig. 1 (116).Fig. 2 i Illustrate check valve top point on the left of the side view of check valve (116).In this embodiment, check valve comprises top ends Divide the first cylindrical portion (120) that (118) and the bottom from tip portion (118) are extended.First cylindrical portion (120) bottom is the first shelf (122) outwardly and downwardly extended from the bottom of the first cylindrical portion (120).Here show Go out a slit (128) on the first shelf (122) top, and described slit has become non-90 degree relative to shelf any edge Angle.First shelf can have multiple slit.The bottom of the first shelf is connected to the top of the second cylindrical portion (124).Second The bottom of cylindrical portion be connected to relative to the bottom of the second cylindrical portion (124) can inwardly and downwardly extend second every Plate (126).In some embodiments, check valve can be integrally formed a single-piece.Such as, tip portion, the first cylinder Shape part, the first shelf, the second cylindrical portion and the second shelf can be integrally formed as a single-piece.Selectively, single Could be separately formed to one or more parts of valve.

It is unidirectional that Fig. 2 ii illustrates along Fig. 2 i midplane AA observed from the right side of check valve (116) shown in Fig. 2 i Valve sectional view.Described cross sectional view show is corresponding to multiple recesses along check valve the first shelf circumference of slit (128) (128).It can be hollow that middle circle (136) illustrates check valve (116).In other embodiments, check valve is permissible It is solid.In other embodiments, check valve is not hollow.

Fig. 2 iii illustrates the sectional view along Fig. 2 i midplane BB observed from the lower left of check valve shown in Fig. 2 i. Illustrate slit (128).

Fig. 2 iv-2vi illustrates the check valve along Fig. 2 i midplane AA observed from the right side of check valve shown in Fig. 2 i The sectional view of a part.Illustrate the different geometries of the slit that can be formed in the check valve top shelf of Fig. 2 i.Regard at this Slit geometry in figure can be formed by curved surface (Fig. 2 iv), two surfaces (Fig. 2 v) or three surfaces (Fig. 2 vi). The profile geometric shape of slit can be bending, angled or their combination in any.

Fig. 3 illustrates the structure being activated of intranasal delivery device shown in Fig. 1, and air or gas are from manual air Pump (104) is to the current path of nozzle (114).Remove can be removed from intranasal delivery device (100) and maybe can crush lid (134).Check valve (116) can lean against on the surface of bottle throat (108).User compresses as manual air pump (104) Flexible bladder (102) (flexible bladder deformed by arrow and the bottle relative to Fig. 1 illustrates compression).Air flows out soft The flow export (106) of property bottle (102).Air-flow causes check valve (116) to rise in nozzle (114).When check valve (116) exists When rising in nozzle, it can no longer stay in bottle throat (108).Check valve the first shelf (122) non-slit part and nozzle Pipe (130) contact, thus stop powdered treatment preparation to be upstream manoeuvred into flexible bladder (102).Air is along unidirectional Second shelf (126) of valve (116) and second cylindrical portion (124) of check valve (116) are advanced, and flow through check valve Slit (128) in (116) first shelves (122).Then, air the first cylindrical portion (120) and blast tube (130) it Between flow into storage chamber (138) and force powdered treatment preparation (M) rise through blast tube (130) and leave nozzle bore (132)。

Fig. 4 illustrates the another embodiment of intranasal delivery device.View left-half is that nozzle exterior part is cut Fall the portion of external view of the intranasal delivery device of a part, it is hereby achieved that outside check valve (414) a kind of embodiment Portion's view.View right half part is the sectional view of intranasal delivery device, including the sectional view of check valve (414).Intranasal delivery fills Putting that (400) can comprise can be as the flexible bladder (402) of manual air pump (404).Flexible bladder can comprise and is positioned at flexibility Bottle top, throat (406) that diameter is more narrower than bottom flexible bladder.Throat (406) can comprise for connecting nozzle (412) External screw thread (410).The female thread of nozzle bottom can match with bottle throat external screw thread (410).

Check valve (414) can partly be positioned at blast tube (416).Check valve can comprise tip portion (418), the first cylinder Shape part (420), the first shelf (422), the second cylindrical portion (424) and bottom (426).Bottom can be cylindric from second Part stretches out.Flat end can be arranged at bottom.Or, end that is that bending can be arranged at bottom or that tilt.Implement at some In mode, bottom can be rigid.Or, bottom can have one or more opening leading to check valve hollow space or Hole.One or more slits (428) can be on the surface (422) of the first shelf.When manual air pump is compressed, one Or multiple slit (428) can allow air or gas to flow to nozzle (412) from flexible bladder (402).

Intranasal delivery device (400) can also comprise nozzle (412), and it can comprise and can be inserted into or be partially inserted into The nasal cavity of experimenter or intranarial blast tube (416).Nozzle (412) can also comprise removable maybe can crush lid (430), The storage chamber (434) of nozzle bore (432) and powdered treatment preparation.Nozzle (412) can also comprise for being connected to flexible bladder (402) screw thread (436).

Fig. 5 is the enlarged drawing at Fig. 4, and left side illustrates check valve (414) external view, illustrates check valve (414) on right side Sectional view.Illustrate a part and throat's screw thread (408) of flexible bladder throat (406).Illustrate blast tube (416) and nozzle A part for bottom (436).

As directed, air intake (438) is in flexible bladder throat (406).Air can enter by being connected to air Interval (440) between nozzle bottom and the flexible bladder throat of mouth (438) enters bottle.As directed, nozzle bottom (436) A part be connected to flexible bladder throat (406), a part for nozzle threads (442) and a part for blast tube (416) and The storage chamber (434) of powdered treatment preparation is also shown as.

Check valve (414) can comprise tip portion (418), the first cylindrical portion (420), the first shelf (422), Two cylindrical portion (424) and bottom (426).Check valve (414) can also comprise lean against lower section protuberance (bulge) (446) on Spine (ridge) (444), to prevent powdered treatment preparation to be upstream manoeuvred in flexible bladder.Check valve is permissible It is hollow.

In the embodiment shown in Fig. 4 and Fig. 5, when manual air pump is activated, check valve (414) moves up, The spine (444) of check valve moves away lower section protuberance (446) of blast tube (416).First shelf of check valve (414) (422) the top spine (448) of contact nozzle pipe, prevents moving upward of check valve (414).Air or gas are at the second circle Flow through between barrel (424) and blast tube (416), flow through slit (428), and from the first cylindrical portion (420) and Blast tube flows through between (416), forces powdered treatment preparation in powdered treatment preparation storage chamber (434) along on nozzle Rise.

Device height

Device described herein can be that application any of powdered treatment preparation facilitates size.Such as, device height is permissible It is about 3-15cm, 4-15cm, 5-15cm, 6-15cm, 7-15cm, 8-15cm, 3-10cm, 3-9cm or 3-8cm.Device height can To be about 3cm, about 4cm, about 5cm, about 6cm, about 7cm, about 8cm, about 9cm, about 10cm, about 11cm, about 12cm, about 13cm, about 14cm or about 15cm.Device height can be greater than about 3cm, about 4cm, about 5cm, about 6cm, about 7cm, about 8cm, about 9cm, about 10cm, about 11cm, about 12cm, about 13cm, about 14cm or about 15cm.Device height can be less than about 3cm, about 4cm, about 5cm, about 6cm, about 7cm, about 8cm, about 9cm, about 10cm, about 11cm, about 12cm, about 13cm, about 14cm or about 15cm.Plant bulk is permissible Based on the amount of powdered treatment compositions to be delivered, comfort, carry comfortableness or manufacture on facility and select.

Device volume

As described herein, device can be configured to little size, so that it can store easily or transport. Device volume can be about 1 to 100cm³, about 5 to 90cm³, about 10 to 80cm³, about 25 to 80cm³, about 50 to 100cm³, about 1 to 50cm³, about 5 to 75cm³, about 1 to 25cm³, about 5 to 50cm³, about 10 to 50cm³Or about 25 to 50cm³.Device volume can be At least about 1,2,5,10,25,30,40,50,75 or 100cm³.Device volume can be less than about 250,200,175,150,125, 100,75,70,65,60,55,50,40,30,25,10,5,2 or 1cm³。

Device width

At its widest part, device width can be about 0.5-5cm.The device width of the widest part can be about 0.5,1,1.5, 2,2.5,3,3.5,4,4.5 or 5cm.The device width of the widest part may be greater than about 0.5,1,1.5,2,2.5,3,3.5,4, 4.5 or 5cm.The device width of the widest part can be less than about 0.5,1,1.5,2,2.5,3,3.5,4,4.5 or 5cm.

Device quality

Device can be configured to lightweight.Such as, the gross mass of device can not about 1 to about 50 gram, about 5 to about 40 grams, About 10 to about 35 grams, about 10 to about 30 grams, about 10 to about 25 grams, about 1 to about 10 gram, about 1 to about 5 gram or about 10 to about 20 grams. The gross mass of device can be less than about 100 grams, 90 grams, 80 grams, 75 grams, 70 grams, 65 grams, 60 grams, 55 grams, 50 grams, 45 grams, 40 Gram, 35 grams, 30 grams, 25 grams, 20 grams, 10 grams, 9 grams, 8 grams, 7 grams, 6 grams, 5 grams, 4 grams, 3 grams, 2 grams, 1 gram, 0.5 gram or less. The gross mass of device can be greater than about 0.5 gram, 1 gram, 2 grams, 3 grams, 4 grams, 5 grams, 6 grams, 7 grams, 8 grams, 9 grams, 10 grams, 11 grams, 12 grams, 13 grams, 14 grams, 15 grams, 16 grams, 17 grams, 18 grams, 19 grams, 20 grams, 25 grams, 30 grams, 35 grams, 40 grams, 45 grams, 50 grams, 55 Gram, 60 grams, 65 grams, 70 grams, 75 grams, 80 grams, 85 grams, 90 grams, 95 grams or 100 grams.The gross mass of device can be about 1 gram, 2 Gram, 3 grams, 4 grams, 5 grams, 6 grams, 7 grams, 8 grams, 9 grams, 10 grams, 11 grams, 12 grams, 13 grams, 14 grams, 15 grams, 16 grams, 17 grams, 18 grams, 19 grams, 20 grams, 25 grams, 30 grams, 35 grams, 40 grams, 45 grams, 50 grams, 55 grams, 60 grams, 65 grams, 70 grams, 75 grams, 80 grams, 85 grams, 90 Gram, 95 grams or 100 grams.Gross mass can be free from the device quality of powdered treatment preparation, or containing powdered treatment The device quality of preparation.

Device delivery efficiency

As described herein, device can be arranged to the single dose powdered treatment preparation of a sizable part (powdered composition) is delivered to the nostril of experimenter.Device can be configured to reside at dress by what a sizable part was measured Put the interior powdered treatment formulation delivered nostril to experimenter.Powdered treatment preparation or its sizable part are at device Can be delivered after single actuation.Activating device can be such as to compress the flexible bladder as manual air pump.Through such as 2, 3, after the repeatedly activation device of 4,5,6,7,8,9 or 10 times, the powdered treatment preparation of a sizable part can be delivered.Dress That puts repeatedly activates the first use that may be constructed device.The sizable a part of powdered treatment can being delivered by device Preparation can be at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5%, 99%, 99.1%, 99.2%, 99.3%, 99.4%, 99.5%, 99.5%, 99.6%, 99.7%, the amount of the powdered treatment preparation of 99.8%, 99.9%, 99.95% or 100%, such as amount in single dose or Person resides at the amount in device.The sizable a part of powdered treatment preparation can being delivered by device be can be about 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5%, 99%, 99.1%, 99.2%, 99.3%, 99.4%, 99.5%, 99.5%, 99.6%, 99.7%, 99.8%, 99.9%, The amount of the powdered treatment preparation of 99.95% or 100%, such as amount in single dose or reside at the amount in device.? In some cases, about 60-100%, 60-99%, 60-95%, 60-90%, 60-85%, 60-80%, 60-75%, 60- 70%, 70-100%, 70-99%, 70-95%, 70-90%, 70-85%, 70-80%, 75-100%, 75-99%, 75- 95%, 75-90%, 75-85%, 75-80%, 80-100%, 80-99%, 80-95%, 80-90%, 80-85%, 85- 100%, 85-99%, 85-95%, 85-90%, 90-100%, 90-99%, 90-95%, 95-100% or 95-99% Powdered treatment amount of formulation is discharged after activating for the first time from device.In this case, second time activates and can cause Discharge essentially all of powdered treatment preparation.In device, residual powder shape treatment preparation is 1% or less usual work The essentially all of powdered treatment preparation of delivery is may be constructed for the form of residual powder on chamber wall.

A. nozzle

Provided herein is the nozzle being suitable for delivering powdered treatment preparation to the nostril of experimenter.At a kind of embodiment In, nozzle is suitable for the most partially or even wholly being placed in the nostril of experimenter.Another kind of embodiment party In formula, nozzle is suitable for being placed to outside, nostril and next-door neighbour nostril, completely or partially covers outlet nostril.

Nozzle form

Nozzle disclosed herein is not limited to specific shape.Nozzle can have a uniform width, such as cylindric, Cubic, rhombohedron shape or parallelepiped.Nozzle can also be a funnel or frustum (frustum) shape, tool There are wide end and narrow end.The shape of nozzle can be wider narrower in downstream at upstream extremity.Nozzle can downstream wider Upstream extremity is narrower.But in other embodiments, the widest and narrowest part of nozzle is not in any one end.Such as, nozzle Widest portion can swim over to any position of downstream shaft on edge.In nozzle, in widest portion is located along the length of axis During point, widest portion can play pause effect to prevent nozzle to be further inserted in nostril.In some embodiments, spray Mouth is made up of the shape of any shape the most presented herein of two or more.Such as, nozzle can comprise cylindrical portion And cone portion.Nozzle can comprise the part (such as blast tube) being designed for inserting nostril, and is designed for connecting The part (such as nozzle bottom) of the throat of flexible bladder such as it is connected to air source.

Nozzle material

Nozzle can be by multiple polymers, plastics, rubber, silicones, metal, composite, applicable use described herein In manufacturing other material any of applicator device or being suitable as any other material of applicator nozzle and formed.Nozzle Can be made up of a kind of material or a class material.Nozzle can be by the different materials of two or more or material category institute group Become.All or part of nozzle can be biocompatible materials or by low irritability material.In some embodiments, nozzle is By silicones, styrene butadiene block copolymer (SBS), polyacetals, polyformaldehyde, acrylate, polyethylene, polyurethane, water Gel, polyester (such as, from E.I.Du Pont de Nemours and Company, Wilmington, Del.'s DACRONB), polypropylene, politef (PTFE), varicosity PTFE (e PTFE), polyether-ether-ketone (PEEK), nylon, extrusion Collagen protein, polymer foams, rubber, silicone rubber, polyethylene terephthalate, ultra-high molecular weight polyethylene, poly- Carbonic ester carbamate (polycarbonate urethane), polyimides, aluminum, rustless steel, Nitinol are (such as Nitinol), titanium, rustless steel or cochrome (such as, from Elgin Specialty Metals, Elgin, Ill.'s ELGILOYB；From Carpenter Metals Corp., the CONICHROMEB of Wyomissing, Pa.) composition.

Nozzle opacity

Nozzle can be made up of transparent or semitransparent material partially or completely.Use the transparent or semitransparent nozzle can To allow visual inspection nozzle whether there is the residual powder shape the perceived treatment residuing in storage chamber after determining use Preparation (powdered composition).If on inspection, experimenter notices has residual powder shape to treat preparation in storage chamber, experimenter can To activate air source again or in multiple times, then check whether to be enough to pass by the transparent or semitransparent nozzle of visual inspection Send.This process can repeat to guarantee to deliver enough dosage as required.This nozzle can be partially or completely by impermeable Bright or be substantially non-transparent material composition.Such as, if device contains light activated powdered treatment preparation, opaque nozzle Or be substantially non-transparent material photaesthesia powdered treatment preparation can be protected to avoid being exposed under light.

Nozzle rigidity

The material of nozzle can be soft, pliable and tough or ductile material so that this nozzle can meet experimenter's nose The shape in hole.Nozzle can be by rigidity, substantially rigid, flexibility or the material of substantial flexibility or combinations thereof Formed.Nozzle can be at one end rigid such as polymer, plastics, silicones, metal or composite, and The other end is that soft, ductile or pliable and tough material, such as nozzle are placed to that end intranarial.Soft, pliable and tough or Ductile material can provide minimizing advantage of injured probability in contact process between experimenter nostril and nozzle.If Device is by third party such as doctor, nurse, the service man of sanatorium, emergency medical technical personnel, paramedical personnel, family Length, guardian or other care-givers make for delivering powdered treatment preparation to experimenter (such as child or old man), and minimizing is subject to The probability of wound can be favourable.

Nozzle/nasal cavity inserts

In some embodiments, nozzle has the size substantially fitted within experimenter nostril.Such as, make During device, at least 10%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 90% or 95% Nozzle can fit into inside experimenter nostril.Using during device, less than about 10%, 20%, 25%, 30%, 40%, the nozzle of 50%, 60%, 70%, 75%, 80%, 90% or 95% can fit into inside experimenter nostril.Using During device, the device nozzle of about 5% to about 90% can fit into inside experimenter nostril.In other embodiments, During using device, about 5% to 75%, 10% to 50%, 10% to 30%, 20% to 60% or 30% to 90% Device nozzle can fit into inside experimenter nostril.Using during device, about 10%, 20%, 25%, 30%, 40%, 50%, the nozzle of 60%, 70%, 75%, 80%, 90% or 95% can fit into inside experimenter nostril.

Blast tube/nasal cavity inserts

Nozzle can comprise the blast tube for inserting nostril and such as being connected to the base section of air source.At some In embodiment, blast tube has the size substantially fitting into experimenter nostril.Such as, during using device, extremely The blast tube of few 10%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 90% or 95% be suitable for into Enter experimenter nostril.Using during device, less than 10%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 75%, the blast tube of 80%, 90% or 95% fits into experimenter nostril.During using device, about 5% to about The device nozzle pipe of 90% fits into experimenter nostril.In other embodiments, use during device, about 5% to 75%, the device nozzle pipe of 10% to 50%, 10% to 30%, 20% to 60% or 30% to 90% fits into experimenter Nostril.Use during device, about 10%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 90%, Or the blast tube of 95% fits into experimenter nostril.In some embodiments, nozzle bottom part can fit into and be subject to Examination person nostril.Such as, use during device, at least 10%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 75%, the nozzle bottom of 80%, 90% or 95% fits into experimenter nostril.During using device, less than 10%, 20%, the nozzle bottom of 25%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 90% or 95% fits into and is subject to Examination person nostril.During using device, bottom the device nozzle of about 5% to 90%, fit into experimenter nostril.At other In embodiment, during using device, about 5% to 75%, 10% to 50%, 10% to 30%, 20% to 60% or 30% Experimenter nostril is fitted into the device nozzle of 90%.Use during device, about 10%, 20%, 25%, 30%, 40%, the nozzle bottom of 50%, 60%, 70%, 75%, 80%, 90% or 95% fits into experimenter nostril.Or, In some embodiments, nozzle bottom part is not suitable for entering experimenter nostril.

Nozzle length

Nozzle length can be measured from upstream extremity to downstream, wherein upstream and downstream refer to device operation during gas or The flow direction (i.e. air or other propellant can be from upstream to downstream flow) of other propellants.The length of nozzle can comprise Blast tube and the length of nozzle bottom part.The length of nozzle can be the length of blast tube.Nozzle middle and upper reaches to downstream Length can be less than about 5cm, less than about 4.5cm, less than about 4cm, less than about 3.5cm, less than about 3cm, less than about 2.5cm, Less than about 2cm, less than about 1.5cm, less than about 1.0cm or less than about 0.5cm.The length of nozzle can be about 0.5cm to 5cm, Between about 1cm to 5cm, about 1cm to 4cm, about 1cm to 3cm, about 2cm to 5cm or about 2cm to 4cm.The length of nozzle can be About 0.5cm, 1cm, 1.5cm, 2cm, 2.5cm, 3cm, 3.5cm, 4cm, 4.5cm or 5cm.The length of nozzle can be greater than about 0.5cm, 1cm, 15cm, 2cm, 2.5cm, 3cm, 3.5cm, 4cm, 4.5cm or 5cm.

Blast tube length

Nozzle can comprise the blast tube for being inserted into nostril and for being connected to the throat portion of air source.Blast tube Length can be measured from upstream extremity to downstream, and wherein upstream and downstream refers to operate air or other propellants during device The direction (i.e. air or other propellant can be from upstream to downstream flow) of flowing.The length swimming over to downstream on blast tube is permissible It is less than about 5cm, less than about 4.5cm, less than about 4cm, less than about 3.5cm, less than about 3cm, less than about 2.5cm, less than about 2cm, less than about 1.5cm or less than about 1.0cm.The length of blast tube can be about between 0.5cm to 5cm, about 1cm to 5cm, About 1cm to 4cm, about 1cm to 3cm, about 2cm to 5cm or about 2cm to 4cm.Blast tube length can be about 0.5cm, 1cm, 1.5cm, 2cm, 2.5cm, 3cm, 3.5cm, 4cm, 4.5cm or 5cm.Blast tube length can be greater than about 0.5cm, 1cm, 1.5cm, 2cm, 2.5cm, 3cm, 3.5cm, 4cm, 4.5cm or 5cm.

External nozzles width

In some embodiments, be perpendicular to nozzle upstream to the external width widest portion of downstream shaft be about 0.1cm extremely 4cm, 1cm are to about 4cm, 1cm to about 3cm, 1cm to about 2cm, 2cm to about 4cm or 2cm to about 3cm, 0.1cm to 2cm, 0.5cm To 2cm or 1 to 2cm.In some embodiments, being perpendicular to nozzle upstream to the external width widest portion of downstream shaft is not surpass Cross about 0.5cm, 1cm, 1.5cm, 2cm, 2.5cm, 3cm, 3.5cm, 4cm, 4.5cm, 5cm width.In some embodiments, vertically External width widest portion in nozzle upstream to downstream shaft be about 0.1cm, 0.2cm, 0.3cm, 0.4cm, 0.5cm, 0.6cm, 0.7cm、0.8cm、0.9cm、1.0cm、1.2cm、1.4cm、1.6cm、1.8cm、2.0cm、2.2cm、2.4cm、2.6cm、 2.8cm, 3cm, 3.2cm, 3.4cm, 3.6cm, 3.8cm, 4cm, 4.2cm, 4.4cm, 4.6cm, 4.8cm or 5cm.Implement at some In mode, be perpendicular to nozzle upstream to the external width widest portion of downstream shaft exceed about 0.1cm, 0.2cm, 0.3cm, 0.4cm, 0.5cm、0.6cm、0.7cm、0.8cm、0.9cm、1.0cm、1.2cm、1.4cm、1.6cm、1.8cm、2.0cm、2.2cm、 2.4cm, 2.6cm, 2.8cm, 3cm, 3.2cm, 3.4cm, 3.6cm, 3.8cm, 4cm, 4.2cm, 4.4cm, 4.6cm, 4.8cm or 5cm。

In some embodiments, be perpendicular to nozzle upstream to downstream shaft external width narrowest part no more than about 0.1cm, 0.25cm, 0.5cm, 0.75cm, 1.0cm, 1.5cm, 2.0cm, 2.5cm or 3.0cm.In some embodiments, hang down Straight be positioned in the external width narrowest part of nozzle upstream to downstream shaft 0.5cm to 3.0cm, 1.0 to 2.5cm, 1.0 to 2.0cm, Within the scope of 0.1cm to 2.0cm, 0.5cm to 1.5cm.In some embodiments, nozzle upstream it is perpendicular to downstream shaft External width narrowest part be about 0.1cm, 0.2cm, 0.3cm, 0.4cm, 0.5cm, 0.6cm, 0.7cm, 0.8cm, 0.9cm, 1.0cm、1.2cm、1.4cm、1.6cm、1.8cm、2.0cm、2.2cm、2.4cm、2.6cm、2.8cm、3cm、3.2cm、3.4cm、 3.6cm, 3.8cm, 4cm, 4.2cm, 4.4cm, 4.6cm, 4.8cm or 5cm.In some embodiments, it is perpendicular to nozzle upstream External width narrowest part to downstream shaft be greater than about 0.1cm, 0.2cm, 0.3cm, 0.4cm, 0.5cm, 0.6cm, 0.7cm, 0.8cm、0.9cm、1.0cm、1.2cm、1.4cm、1.6cm、1.8cm、2.0cm、2.2cm、2.4cm、2.6cm、2.8cm、3cm、 3.2cm, 3.4cm, 3.6cm, 3.8cm, 4cm, 4.2cm, 4.4cm, 4.6cm, 4.8cm or 5cm.

Nozzle width can with consecutive variations, can be changed stepwise, not change or a combination thereof.The inner or outer width of nozzle Degree can with continually varying, can be changed stepwise, not change or a combination thereof.Nozzle upstream and downstream can be identical Or different width.In some embodiments, narrow end is to be placed to experimenter nostril middle-end before administration with period Portion.In some embodiments, nozzle is the widest and narrowest part is in end.Such as, nozzle widest portion can be in At upstream extremity, and nozzle narrowest part can be in downstream end, or vice versa as the same.In some embodiments, nozzle The widest and/or narrowest part is not in end.In some embodiments, nozzle widest portion is placed in powdered treatment preparation In storage chamber.In some embodiments, nozzle widest portion is the nozzle bottom for being connected to manual air pump.

Inwardly projecting orifice width

In some embodiments, being perpendicular to nozzle upstream to the inner width widest portion of downstream shaft is at about 0.1cm To 4cm, 1cm to about 4cm, 1cm to about 3cm, 1cm to about 2cm, 2cm to about 4cm or 2cm to about 3cm, 0.1cm to 2cm, 0.5cm to 2cm or 1 to 2cm.In some embodiments, the nozzle upstream inner width widest portion to downstream shaft it is perpendicular to No more than about 0.5cm, 1cm, 1.5cm, 2cm, 2.5cm, 3cm, 3.5cm, 4cm, 4.5cm or 5cm width.At some embodiments In, be perpendicular to nozzle upstream to downstream shaft inner width widest portion more than about 0.5cm, 1cm, 1.5cm, 2cm, 2.5cm, 3cm, 3.5cm, 4cm, 4.5cm or 5cm width.In some embodiments, the nozzle upstream inner width to downstream shaft it is perpendicular to Widest portion be about 0.1cm, 0.2cm, 0.3cm, 0.4cm, 0.5cm, 0.6cm, 0.7cm, 0.8cm, 0.9cm, 1.0cm, 1.2cm、1.4cm、1.6cm、1.8cm、2.0cm、2.2cm、2.4cm、2.6cm、2.8cm、3cm、3.2cm、3.4cm、3.6cm、 3.8cm, 4cm, 4.2cm, 4.4cm, 4.6cm, 4.8cm or 5cm.

In some embodiments, it is perpendicular to nozzle upstream be no more than about to the inner width narrowest part of downstream shaft 0.1cm, 0.25cm, 0.5cm, 0.75cm, 1.0cm, 1.5cm, 2.0cm, 2.5cm or 3.0cm.In some embodiments, hang down Straight in the inner width narrowest part of nozzle upstream to downstream shaft be more than about 0.1cm, 0.25cm, 0.5cm, 0.75cm, 1.0cm, 1.5cm, 2.0cm, 2.5cm or 3.0cm.In some embodiments, the nozzle upstream inside to downstream shaft it is perpendicular to Width narrowest part is positioned at about 0.5cm to 3.0cm；1.0 to 2.5cm or 1.0 to 2.0cm, 0.1cm to 2.0cm, 0.5cm are extremely Within the scope of 1.5cm.In some embodiments, being perpendicular to nozzle upstream to the inner width narrowest part of downstream shaft is about 0.1cm、0.2cm、0.3cm、0.4cm、0.5cm、0.6cm、0.7cm、0.8cm、0.9cm、1.0cm、1.2cm、1.4cm、 1.6cm、1.8cm、2.0cm、2.2cm、2.4cm、2.6cm、2.8cm、3cm、3.2cm、3.4cm、3.6cm、3.8cm、4cm、 4.2cm, 4cm, 4. or.

Nozzle interior volume

Nozzle can be hollow and can comprise internal capacity.Nozzle interior volume can be about 5cm³Or less, 4cm³ Or less, 3cm³Or less, 2cm³Or less, 1cm³Or less, 0.5cm³Or it is less.In some embodiments, nozzle interior Volume is about 1cm³To about 5cm³, about 1cm³To about 4cm³, about 1cm³To about 3cm³, about 1cm³To about 2cm³, about 0.1cm³To about 2cm³, about 0.1cm³To about 1cm³.Nozzle interior volume can be about 0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9, 1.0、1.2、1.3、1.4、1.5、1.6、1.7、1.8、1.9、2.0、2.1、2.2、2.3、2.4、2.5、2.6、2.7、2.8、2.9、 3,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9 or 5.0cm³.Nozzle interior volume can be more than about 0.5,1,1.5,2,2.5,3,3.5,4,4.5 or 5cm³.Nozzle interior volume Can less than about 0.5,1,1.5,2,2.5,3,3.5,4,4.5 or 5cm³。

Nozzle as storage chamber

Nozzle can comprise to be suitable for accommodating to be controlled for delivery to the powder of experimenter's intranarial powdered treatment preparation Treat preparation storage chamber.In some cases, powdered treatment agent storage chamber is formed by nozzle completely.In other cases, storage chamber is Formed by portion nozzle and the partially unidirectional valve of device and/or air source or its assembly.Such as, the downstream of storage chamber can be by spray Mouth is formed, and the upstream extremity of storage chamber can be formed (see for example Fig. 1) by check valve and air source and assembly thereof.Storage chamber is permissible Being the integral part of nozzle, removing or replacing of it can not be carried out independent of removing or replacing of nozzle itself.Storage chamber is permissible It it is unitary part replaceable, that can be inserted into or can be removed.In some embodiments, replaceable, can be inserted into or removable Storage chamber is capsule or the form of cylinder (cartridge).In some embodiments, replaceable storage chamber is not capsule.Can exist Check valve or other device regulate air, propellant or powdered treatment agent from the flowing of storage chamber.Can exist check valve or Other device regulates air, propellant or powdered treatment agent and enters the flowing of storage chamber.In some embodiments, nozzle Housing the single powdered treatment preparation storage chamber being placed in nozzle, it is suitable for accommodating for delivery to experimenter nostril Interior powdered treatment preparation.By by the design of medicine storage chamber in nozzle close at exit opening, device activate after residual Medication amount can be minimized, such as viscous medicaments or for being bonded on plastics due to such as the reason such as adhesiveness, electrostatic Powder.

Nozzle storage chamber volume

In some embodiments, powdered treatment preparation storage chamber volume can be about 5cm³Or less, 4cm³Or less, 3cm³Or less, 2cm³Or less, 1cm³Or less or 0.5cm³Or it is less.In some embodiments, powdered treatment preparation The volume of storage chamber can be about 1cm³To about 5cm³, about 1cm³To about 4cm³, about 1cm³To about 3cm³, about 1cm³To about 2cm³, about 0.1cm³To about 2cm³, about 0.1cm³To about 1cm³.The volume of powdered treatment preparation storage chamber can be about 0.1,0.2,0.3, 0.4、0.5、0.6、0.7、0.8、0.9、1.0、1.2、1.3、1.4、1.5、1.6、1.7、1.8、1.9、2.0、2.1、2.2、2.3、 24、25、26、27、2.8、2.9、3、3.1、3.2、3.3、3.4、3.5、3.6、3.7、 3.8、3.9、4.1、4.2、4.3、4.4、 4.5,4.6,4.7,4.8,4.9 or 5.0cm³.The volume of powdered treatment preparation storage chamber can be more than about 0.5,1,1.5,2, 2.5,3,3.5,4,4.5 or 5cm³.The volume of powdered treatment preparation storage chamber can be less than about 0.5,1,1.5,2,2.5,3, 3.5,4,4.5 or 5cm³。

The amount of powdered treatment preparation in storage chamber

In some embodiments, storage chamber be suitable for storage potion powdered treatment preparation be about 10mg to 2000mg, About 50mg to 1500mg, about 100mg to 1000mg, about 100mg and 500mg, about 500mg to 2000mg or about 1000mg are extremely 2000mg powdered treatment preparation.In some embodiments, storage chamber be suitable for storing at least 10mg, 50mg, 100mg, The powder of 200mg, 300mg, 400mg, 500mg, 600mg, 700mg, 800mg, 900mg, 1000mg, 1500mg or 2000mg Treatment preparation.In some embodiments, storage chamber be suitable for storing at most 10mg, 25mg, 50mg, 75mg, 100mg, 200mg, The powdered treatment system of 300mg, 400mg, 500mg, 600mg, 700mg, 800mg, 900mg, 1000mg, 1500mg, 2000mg Agent.Storage chamber can store about 10mg, 25mg, 50mg, 75mg, 100mg, 200mg, 300mg, 400mg, 500mg, 600mg, 700mg, The powdered treatment preparation of 800mg, 900mg, 1000mg, 1500mg or 2000mg.Storage chamber is set in some embodiments For preserving the powdered treatment preparation of single dose, and (such as, 2, storage chamber is arranged to preserve repeatedly in other embodiments 3,4,5,6,7,8,9,10) the powdered treatment preparation of dosage.Dosage is referred to experimenter's nonrecoverable powdery treatment system The amount of agent.

Storage chamber can treat preparation by powder filler shape during manufacturing device.Storage chamber being fixed by nozzle or can be connected to sky Powder filler shape treatment preparation before source of the gas.Storage chamber can be filled after nozzle being fixed or is connected to air source or a combination thereof.

Inwardly projecting orifice wall and slit

Inwardly projecting orifice wall also can comprise one or more slit (ditch or groove).Slit or groove can be by curved surfaces (such as semicircle；See for example Fig. 2 iv), two surfaces (see for example Fig. 2 v), three surfaces (see for example Fig. 2 vi), four Surface, five surfaces, six surfaces, seven surfaces, eight surfaces, nine surfaces or ten surfaces are formed.Inwardly projecting orifice wall Slit or groove can have at least 1,2,3,4,5,6,7,8,9 or 10 kind of multi-form.One or more slits can be used for Device storage chamber, rotation is produced when a device is activated (such as when air enters powdered treatment preparation storage chamber from air source) Whirlpool.Eddy current can make to deliver powdered treatment preparation completely.One or more slits can be positioned so that the laminar flow allowed in storage chamber Air-flow.

Slit or groove number

Inwardly projecting orifice wall can have at least 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18, 19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、 44、45、46、47、48、49、50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、 69、70、71、72、73、74、75、76、77、78、79、80、81、82、83、84、85、86、87、88、89、90、91、92、93、 94,95,96,97,98,99 or 100 slits or grooves.Inwardly projecting orifice wall energy has less than 1,2,3,4,5,6,7,8,9,10, 11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、 36、37、38、39、40、41、42、43、44、45、46、47、48、49、50、51、52、53、54、55、56、57、58、59、60、 61、62、63、64、65、66、67、68、69、70、71、72、73、74、75、76、77、78、79、80、81、82、83、84、85、 86,87,88,89,90,91,92,93,94,95,96,97,98,99 or individual 100 slit or groove.Inwardly projecting orifice wall can have About 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28, 29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、49、50、51、52、53、 54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、72、73、74、75、76、77、78、 79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99 or 100 slits or Groove.Inwardly projecting orifice wall energy has about 1-100,1-90,1-80,1-70,1-60,1-50,1-40,1-30,1-25,1-20 or 1- 10 slits or groove.

Slit or groove location

Slit or groove can be substantially parallel to each other on inwardly projecting orifice wall.In some embodiments, all of narrow Seam or groove are not substantially parallel to each other on inwardly projecting orifice wall.In some embodiments, all of slit or groove exist It is not evenly spaced apart on inwardly projecting orifice wall.In some embodiments, all of slit or groove are on inwardly projecting orifice wall It is evenly spaced apart.

Slit or the length of groove

Slit can have about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21, 22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、 47、48、49、50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、 72、73、74、75、76、77、78、79、80、81、82、83、84、85、86、87、88、89、90、91、92、93、94、95、96、 97, the length of 98,99 or 100 millimeters.Slit can have less than about 1,2,3,4,5,6,7,8,9,10,11,12,13,14, 15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、 40、41、42、43、44、45、46、47、48、49、50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、 65、66、67、68、69、70、71、72、73、74、75、76、77、78、79、80、81、82、83、84、85、86、87、88、89、 90, the length of 91,92,93,94,95,96,97,98,99 or 100 millimeters.Slit can have greater than about 1,2,3,4,5,6,7, 8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、 34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、49、50、51、52、53、54、55、56、57、58、 59、60、61、62、63、64、65、66、67、68、69、70、71、72、73、74、75、76、77、78、79、80、81、82、83、 84, the length of 85,86,87,88,89,90,91,92,93,94,95,96,97,98,99 or 100 millimeters.

The shape of powdered treatment preparation storage chamber

Powdered treatment preparation storage chamber is not limited to any specific shape, it is possible to be set to spherical, ellipse in nozzle Any other of spherical, cylindric, cubic, frustum (frustum) or any one shape the most described herein closes Suitable shape.In some embodiments, select storage chamber shape so that exist angle, sharp edges or other can upset air-flow Surface character minimize.In some embodiments, storage chamber shape is selected will not to experience in equipment operating process to eliminate Uniformly, laminar flow or the region of high gas flow.This can have minimizing powdered treatment preparation in bulk (clump) or thus gather The effect of the position in the storage chamber of the powdered treatment preparation total amount that reduction is delivered in experimenter nostril and nozzle.Example As, powdered treatment preparation storage chamber can be the shape of frustum or parallelepiped, and the most all corners are rounded.One In a little embodiments, powdered treatment preparation storage chamber is by the shape group of two or more the most any shapes Become.Such as, powdered treatment preparation storage chamber can comprise cylindrical portion and cone portion.Or, as just example, powder Shape treatment preparation storage chamber can be included in two cone portion of its widest end combination or by cylindrical portion between Two cone portion being connected.In some embodiments, powdered treatment preparation storage chamber inner surface is smooth.Or Person, interior surface can be coarse.In some embodiments, can provide in powdered treatment preparation storage chamber one or Multiple internal surface feature.One or more spine, groove, projection, projection can be provided on the inner surface of storage chamber (bump), passage or other surface character.These surface character can affect air-flow and the delivery of powdered treatment preparation.

Nozzle current limiter

Nozzle can comprise current limiter, is suitable for limiting by least one of air-flow of device, thus is increased or decreased Air velocity in device or the airflow direction in change device.In some embodiments, current limiter is the downstream at nozzle End.Current limiter can be at the upstream extremity of nozzle.Can have current limiter at nozzle upstream end and downstream simultaneously.Implement at some In mode, current limiter is arranged on nozzle downstream, and width smoothly shrinks to downstream from upstream extremity.Or, current limiter Can from upstream extremity to downstream Stepwize Shrink, or can with progressively with continuous print hybrid mode shrink.This contraction can be Device operating process improves air and/or the speed of powdered treatment agent entering experimenter nostril from nozzle.Real at some Executing in mode, the current limiter retracted downward being arranged on nozzle downstream leaves nozzle to air in operation and powdered treatment agent Nozzle bore.

Nozzle current limiter shape

Current limiter can provide from along nozzle inner walls to entering the air at air-flow fluid center or other propellants Redirect.Current limiter can be configured so that and guides air flowing in the way of similar laminar flow from along nozzle inner walls.Current limiter Can be configured to, with turbulent flow pattern, air-flow imports powdered treatment preparation storage chamber.Current limiter can be configured at device Vortex is provided at least partially in powdered treatment preparation storage chamber during use.The air being re-directed to that current limiter provides Stream can make the caking of powdered treatment preparation in storage chamber or at least some of broken of accumulation.The air stream being re-directed to is permissible During guaranteeing conventional use device, present in storage chamber, sizable a part of powdered treatment preparation is delivered to tested The nostril of person.Such as, the powder that the air stream being re-directed to that current limiter provides with turbulent closure scheme thus can be atomized effectively Shape therapeutic agent.Current limiter can be any one in various shape, comprises but is not limited to coniform, cylindric, taper cone barrel, truncate Head body and parallelepiped or other shape any provided in this article, comprise the combination of one or more shapes.

Nozzle current limiter width

Current limiter can be reduced to nozzle bore change width from slightly smaller than nozzle width on width.Such as, current limiter exists On width can from widest portion be at least about 0.1mm, 0.2mm, 0.3mm, 0.4mm, 0.5mm, 0.6mm, 0.7mm, 0.8mm, 0.9mm、1mm、1.5mm、2mm、2.5mm、3mm、4mm、5mm、6mm、7mm、8mm、9mm、10mm、11mm、12mm、13mm、 14mm or 15mm is less than about 0.1mm to current limiter narrowest part, 0.2mm, 0.3mm, 0.4mm, 0.5mm, 0.6mm, 0.7mm, 0.8mm, 0.9mm, 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm or 10mm.The widest point of current limiter can be about 5mm To about 15mm width or about 8mm to 12mm.The narrowest point of current limiter can be about 1mm to about 10mm width, about 2mm to 7mm width, about 0.1mm to 2mm width or about 0.5mm are to about 1.5mm width.

Nozzle current limiter length

Current limiter can have the upstream of at least 20mm, 15mm, 10mm, 5mm, 4mm, 3mm, 2mm or 1mm to lower brigade commander Degree.Current limiter can have the upstream less than 20mm, 15mm, 10mm, 5mm, 4mm, 3mm, 2mm or 1mm to downstream length.Current limliting Device can be to be about 5mm to about 20mm, be about 5mm to about 15mm, be about 5mm to about 10mm, be about 1mm and to about 5mm or be about 0.5mm to about 2.5mm.Current limiter can be long be about 0.5mm, 1mm, 1.5mm, 2mm, 2.5mm, 3mm, 3.5mm, 4mm, 4.5mm, 5mm, 5.5mm, 6mm, 6.5mm, 7mm, 7.5mm, 8mm, 8.5mm, 9mm, 9.5mm or 10mm.

Nozzle bore

Nozzle bore may adapt to the powdered treatment preparation allowing to discharge single logistics form from nozzle.Some embodiment party In formula, nozzle has multiple hole, can keep independent or can be to be merged into the powder of multiple logistics forms of single logistics to release Powder treatment preparation.In some embodiments, nozzle bore is arranged on the downstream of nozzle.In some embodiments, spray Nozzle aperture is also the downstream of current limiter.Nozzle bore can be any one in various shape, includes but not limited to circle, ellipse Shape, triangle, rectangle or combinations thereof.In some embodiments, nozzle is configured to provide at a high speed to experimenter nostril Degree propellant and/or powdered treatment agent.Such as, nozzle can be configured to provide peak velocity to be about 1m/s to about 10m/s, about The propellant of 2m/s to about 8m/s or about 3m/s to about 6m/s.

The width of nozzle bore

In some embodiments, when only existing a hole, the size of nozzle bore is measured as being less than in its widest portion 20mm, less than about 15mm, less than about 12mm, less than about 10mm, less than about 8mm, less than about 5mm, less than about 3mm, less than about 2mm, less than about 1mm or less than about 0.5mm.In the embodiment having more than one nozzle bore, the width in single hole is less than 10mm, less than about 8mm, less than about 6mm, less than about 5mm, less than about 4mm, less than about 3mm, less than about 2mm, less than about 1mm or Less than about 0.5mm.Nozzle bore the width of its widest portion can be about 0.1mm, 0.15mm, 0.2mm, 0.25mm, 0.3mm, 0.35mm、0.4mm、0.45mm、0.5mm、0.55mm、0.6mm、0.65mm、0.7mm、0.75mm、0.8mm、0.9mm、1mm、 1.1mm、1.2mm、1.3mm、1.4mm、1.5mm、1.6mm、1.7mm、1.8mm、1.9mm、2.0mm、2.1mm、2.2mm、 2.3mm、2.4mm、2.5mm、2.6mm、2.7mm、2.8mm、2.9mm、3.0mm.Nozzle bore can be big in its widest portion In about 0.1mm, 0.15mm, 0.2mm, 0.25mm, 0.3mm, 0.35mm, 0.4mm, 0.45mm, 0.5mm, 0.55mm, 0.6mm, 0.65mm、0.7mm、0.75mm、0.8mm、0.9mm、1mm、1.1mm、1.2mm、1.3mm、1.4mm、1.5mm、1.6mm、 1.7mm、1.8mm、1.9mm、2.0mm、2.1mm、2.2mm、2.3mm、2.4mm、2.5mm、2.6mm、2.7mm、2.8mm、 2.9mm、3.0mm.Nozzle bore its widest portion can be less than about 0.1mm, 0.15mm, 0.2mm, 0.25mm, 0.3mm, 0.35mm、0.4mm、0.45mm、0.5mm、0.55mm、0.6mm、0.65mm、0.7mm、0.75mm、0.8mm、0.9mm、1mm、 1.1mm、1.2mm、1.3mm、1.4mm、1.5mm、1.6mm、1.7mm、1.8mm、1.9mm、2.0mm、2.1mm、2.2mm、 2.3mm、2.4mm、2.5mm、2.6mm、2.7mm、2.8mm、2.9mm、3.0mm.Nozzle bore can be about in its widest portion In the range of 0.1mm to 2mm, 0.5mm to 1.5mm or 0.75mm to 1.25mm.

The nozzle bore degree of depth

In some embodiments, nozzle bore is swum over to the degree of depth in downstream, namely from the hole site of nozzle surface to storage The length of the passage that the tip of room or current limiter is formed, less than about 50mm, less than about 40mm, less than about 30mm, less than about 25mm, less than 20mm, less than about 15mm, less than about 10mm, less than about 7mm, less than about 5mm, less than about 3mm or less than about 1mm. In some embodiments, the hole site of nozzle surface is storage chamber or the downstream end effectively producing the 0mm degree of depth.Nozzle bore The degree of depth can exceed about 0.1mm, 0.25mm, 0.5mm, 0.75mm, 1mm, 1.5mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 15mm, 12.5mm, 17.5mm, 20mm, 22.5mm, 25mm, 27.5mm, 30mm, 35mm, 40mm, 45mm or 50mm.The degree of depth of nozzle bore can be about 0.1mm, 0.25mm, 0.5mm, 0.75mm, 1mm, 1.5mm, 2mm, 3mm, 4mm, 5mm, 6mm、7mm、8mm、9mm、10mm、12.5mm、15mm、17.5mm、20mm、22.5mm、25mm、27.5mm、30mm、35mm、 40mm, 45mm or 50mm.

Nozzle bottom

Nozzle can also comprise bottom.Bottom may adapt to provide from manual air room to powdered treatment preparation storage chamber Or the air flowing of nozzle.In some embodiments, bottom is positioned at nozzle upstream end.Throat can additionally or optional Ground is positioned at storage chamber upstream extremity.In some embodiments, bottom is a part for nozzle.Powdered treatment can be formed on bottom A part for preparation storage chamber upstream extremity.In some embodiments, base section is formed by nozzle, and part is formed by check valve. In some embodiments, bottom can accommodate all or part of check valve.

Bottom can be positioned to provide the outlet of the air from manual air pump or propellant, thus allows it to enter nozzle And/or powdered treatment preparation storage chamber.In some embodiments, bottom is configured to accommodate check valve or one of check valve Point.In some embodiments, throat is configured to slidably receive a part for check valve or check valve.Implement at some In mode, it is arranged at the check valve in bottom and stops the powdered treatment preparation upstream movement of nozzle interior such as to enter air Source.Bottom can be any number of shape, comprises but is not limited to coniform, cylindric, cone cylinder shape, frustum, peace Row hexahedron or other shape any provided in this article, including the combination of one or more shapes.

In some embodiments, the upstream of bottom to downstream length less than 20mm, less than 15mm, less than 12mm, be less than 11mm, less than 10mm, less than 9mm, less than 8mm, less than 6mm, 7mm, less than 5mm, less than 4mm or less than 2mm.At some In the case of, the upstream of bottom to downstream length is about 2mm to 20mm, about 5mm to 15mm or about 5mm to 10mm.

In some embodiments, the width being perpendicular to swim on bottom downstream shaft is that about 2mm is to about in widest portion 10mm, about 2mm are to about 8mm or about 2mm to about 5mm.In some embodiments, it is perpendicular to swim on bottom the width of downstream shaft Spend widest portion be at least 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm width, 11mm, 12mm, 13mm, 14mm、15mm、16mm、17mm、18mm、19mm、20mm、21mm、22mm、23mm、24mm、25mm、26mm、27mm、28mm、 29mm or 30mm.Be perpendicular on bottom to swim over to the width of downstream shaft widest portion can be about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm width, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm, 20mm, 21mm, 22mm, 23mm, 24mm, 25mm, 26mm, 27mm, 28mm, 29mm or 30mm.

Bottom throat can comprise one or more screw thread for being connected to such as hand air pump and/or flexible bladder. Can use one or more screw thread that nozzle and manual air pump are threaded together.

Lid

Nozzle can comprise lid.Lid can be positioned in the downstream of nozzle.Selectively, or additionally, lid can To be positioned in the downstream of nozzle bore.Lid can be configured to the unintentionally release of restraining device.Such as, lid can be energy Stop the bubble-tight of any air-flow mass flowing nozzle downstream thus eliminate Inadvertent activation air source and cause release powder to be controlled Treat preparation.This unexpected activation can such as store or transportation in rash-and-rough way of loading and unloading and occur.Lid can also be set Determine into and the environment being suitable to be stored in the powdered treatment preparation in powdered treatment shape preparation storage chamber is provided.Such as, lid is permissible Suppression or block extraneous air and/or water invade nozzle interior thus suppression or block air or water invade powder Medicine storage chamber.Lid can be that interchangeable lid is so that it can be removed and replaced.There is interchangeable lid Time, removable belt can be used to securely lid be tied up on nozzle.Selectively, lid can be to can be removed maybe can break Broken lid, so that it can be removed or (such as, it can be excluded or substituted one or many by breaking from nozzle Put back in situ).Lid can be removable maybe can crush label (tab), the removable film that maybe can crush or removable or can Broken lid (the most airtight lid).

B. check valve

Device described herein comprises at least one check valve.Check valve can be provided in adjusting means from air source And enter nozzle air flowing.Check valve is also configured to regulate the motion of powdered treatment preparation.Check valve energy The equipment that is provided in be not activated (such as hand air pump is uncompressed) time stop and flow to from air or the gas of air source Enter nozzle, and the air from air source or gas stream can be allowed when equipment is activated (such as compressing manual air pump) Enter nozzle.

In some embodiments, check valve is configured to stop powdered treatment preparation upstream direction (such as, to enter Air source) motion (such as passing through gravity).Check valve can be set so that (such as, air source does not has when device is not activated Have and be activated) time its position can being in device, when equipment is activated (such as, air source is activated), it can be in Another location in device.Check valve can be set to when equipment is not activated (such as, manual air pump is uncompressed) Time and when device be activated (such as, manual air pump is compressed) time stop (such as passing through gravity) powdered treatment preparation to The motion (such as, entering into flexible bladder and/or manual air pump) of updrift side.Check valve can comprise relative to device The slit (passage or groove) of inclined main axes, it can produce vortex along storage chamber wall.

Check valve composition

Check valve can by multiple polymers, plastics, rubber, silicones, metal, composite, as herein described be suitable for For manufacture other material any of intranasal delivery device or as herein described be suitable in intranasal delivery device any its Its material.Check valve can be made up of a kind of or a class material.Selectively, check valve can be by two or more different materials Material or different types of material composition.Part or all of check valve can be biocompatible materials or low irritability material Material.Check valve can be by rigidity, substantially rigid, flexible or that be substantially flexibility material or a combination thereof institute group Become.In some embodiments, check valve can be by one or more paper, silicones, styrene-butadiene block copolymer (SBS), polyacetals, polyformaldehyde, acrylate, polyethylene, polyureas alkane, hydrogel, polyester are (such as from E.I.Du Pont de Nemours and Company, the DACRONB of Wilmington, Del.), polypropylene, politef (PTFE), varicosity PTFE (ePTFE), polyether-ether-ketone (PEEK), nylon, the collagen protein of extrusion, polymer foams, rubber, silicone rubber, poly- Ethylene glycol terephthalate, ultra-high molecular weight polyethylene, polycarbonate urethane, polyimides, aluminum, rustless steel, nickel- Titanium alloy (such as, Nitinol), titanium, rustless steel or cochrome (such as, from Elgin Specialty Metals, The ELGILOYB of Elgin, Ill.；From Carpenter Metals Corp., the CONICHROMEB of Wyomissing, Pa.) Composition.

Check valve size

Check valve can be any number of shape, includes but not limited to, discoid, anchor ring (annulus), holder shape, Taper, cylindrical shape, cone cylinder shape, frustum, cubic, parallelepiped or other shape provided in this article any, bag Combination containing one or more shapes.Check valve can have narrow end and wide end.In some embodiments, check valve widest portion Upstream or downstream can not be positioned at.In some embodiments, check valve narrowest part is positioned at upstream or downstream.Check valve Can be hollow.Check valve can have opening in its one end.In some embodiments, check valve does not has in its one end Opening.

Swim on check valve the length in downstream can be less than about 30,29,28,27,26,25,24,23,22,21,20, 19,18,17,16,15,14,13,12,11,10,9,8,7,6 or 5mm.The length of check valve can be about 5mm to 30mm, about 5mm to 20mm, about 5mm to 15mm or about 5mm to 10mm.The length of check valve can be exceed about 5,6,7,8,9,10,11, 12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29 or 30mm.The length of check valve is permissible Be about 5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29 or 30mm。

It is perpendicular on check valve the width swimming over to downstream shaft and can be about 1mm to about 30mm, about 1mm extremely in its widest portion Between about 25mm, about 1mm are to about 20mm, about 1mm to about 15mm, about 1mm to about 10mm, about 1mm to about 5mm.It is perpendicular to unidirectional The width swimming over to downstream shaft on valve can exceed about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm in its widest portion Or 10mm width.Be perpendicular on check valve the width swimming over to downstream shaft its widest portion can be less than about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm or 10mm width.

It is perpendicular on check valve the width swimming over to downstream shaft and can be about 1mm to about 30mm, about 1mm extremely in its narrowest part Between about 25mm, about 1mm are to about 20mm, about 1mm to about 15mm, about 1mm to about 10mm, about 1mm to about 5mm.Implement at some In mode, check valve have be no more than about in its narrowest part 0.5mm, 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, The width that 9mm width, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm are wide.At some In embodiment, check valve have exceed in its narrowest part about 0.5mm, 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, The width that 9mm width, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm are wide.It is perpendicular to Swim on check valve the width of downstream shaft its widest portion or narrowest part can be about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm width.

Check valve is relative to the size of nozzle

Check valve can be configured to be slidably mounted in part or all of nozzle.The width of partially unidirectional valve is permissible It is less than the inner width of blast tube.Such as, at the width of tip portion (such as, such as Fig. 1 (118)) bottom with at the first cylinder The width of shape part (such as, Fig. 1 (120)) bottom can be less than the width of blast tube (such as, Fig. 1 (130)) widest portion.Single Difference to the width of valve the first cylindrical part Yu the inner width of blast tube widest portion can be about 0.01,0.02, 0.03、0.04、0.05、0.06、0.07、0.08、0.09、0.1、0.11、0.12、0.13、0.14、0.15、0.16、0.17、 0.18、0.19、0.2、0.21、0.22、0.23、0.24、0.25、0.26、0.27、0.28、0.29、0.30、0.31、0.32、 0.33、0.34、0.35、0.36、0.37、0.38、0.39、0.40、0.41、0.42、0.43、0.44、0.45、0.46、0.47、 0.48,0.49 or 0.5mm.The difference of the width of check valve the first cylindrical portion and the inner width of blast tube widest portion can With less than about 0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.11,0.12,0.13,0.14, 0.15、0.16、0.17、0.18、0.19、0.2、0.21、0.22、0.23、0.24、0.25、0.26、0.27、0.28、0.29、 0.30、0.31、0.32、0.33、0.34、0.35、0.36、0.37、0.38、0.39、0.40、0.41、0.42、0.43、0.44、 0.45,0.46,0.47,0.48,0.49 or 0.5mm.The width of check valve the first cylindrical portion and blast tube widest portion The difference of inner width can exceed about 0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1, 0.11、0.12、0.13、0.14、0.15、0.16、0.17、0.18、0.19、0.2、0.21、0.22、0.23、0.24、0.25、 0.26、0.27、0.28、0.29、0.30、0.31、0.32、0.33、0.34、0.35、0.36、0.37、0.38、0.39、0.40、 0.41,0.42,0.43,0.44,0.45,0.46,0.47,0.48,0.49 or 0.5mm.First cylindrical portion (see for example figure 3 (118)) width and the difference of the inner width of blast tube (such as Fig. 3 (130)) widest portion can work as manual air pump Allow air from manual air pump to Flow in Nozzle (such as, seeing Fig. 3) when being activated.

Tip portion

Check valve can have some (see for example Fig. 2 i).Check valve can have the most coniform, pyramid-shaped or The tip portion (see, e.g., Fig. 2 i (118)) of trapezoidal shape.Top is divided can a convex surface.Tip portion is passed at intranasal Powdered treatment preparation can be allowed when sending device to be activated to improve flow along the accumulation of nozzle tube wall and assist suitable air Circulation.In some embodiments, top is divided and can also be comprised other part.Part additionally may be connected to top ends Point top portion and can be the most coniform, pyramid-shaped or trapezoidal shape.

Tip portion height

The height of check valve tip portion can be about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.The height of check valve tip portion can be Exceed about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.The height of check valve tip portion can be less than about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.Check valve top The height of end portion can be about 1 to 20mm, about 1 to 10mm, about 1 to 5mm or about 1 to 2.5mm.

Tip portion width

Tip portion base diameter can be about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.Tip portion base diameter can be to exceed About 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, more than 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.Tip portion base diameter can be less than about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.Bottom tip portion Diameter can be about 1 to 20mm, from 1 to 10mm, from 1 to 7.5mm, 1mm to 5mm, from 2.5 to 20mm, from 2.5 to 10mm or 2.5 to 7.5mm.

Tip portion angle

By check valve tip portion surface with to be parallel to the angle that the plane bottom tip portion formed can be obtuse angle.By Check valve tip portion surface and the obtuse angle being parallel to the plane formation bottom tip portion can be from about 179 degree to about 91 Degree, from about 170 to 100 degree, from about 160 to about 110 degree, from about 150 to about 120 degree or from about 140 to about 130 degree.By unidirectional Valve tip portion surface and be parallel to the obtuse angle that plane bottom tip portion formed can be about 179,178,177,176, 175、174、173、172、171、170、169、168、167、166、165、164、163、162、161、160、159、158、157、 156、155、154、153、152、151、150、149、148、147、146、145、144、143、142、141、140、139、138、 137、136、135、134、133、132、131、130、129、128、127、126、125、124、123、122、121、120、119、 118、117、116、115、114、113、112、111、110、109、108、107、106、105、104、103、102、101、100、 99,98,97,96,95,94,93,92 or 91 degree.By check valve tip portion surface and be parallel to the plane bottom tip portion The obtuse angle formed can be less than about 179,178,177,176,175,174,173,172,171,170,169,168,167, 166、165、164、163、162、161、160、159、158、157、156、155、154、153、152、151、150、149、148、 147、146、145、144、143、142、141、140、139、138、137、136、135、134、133、132、131、130、129、 128、127、126、125、124、123、122、121、120、119、118、117、116、115、114、113、112、111、110、 109,108,107,106,105,104,103,102,101,100,99,98,97,96,95,94,93,92 or 91 degree.By unidirectional Valve tip portion surface and be parallel to the obtuse angle that plane bottom tip portion formed can be exceed about 179,178,177, 176、175、174、173、172、171、170、169、168、167、166、165、164、163、162、161、160、159、158、 157、156、155、154、153、152、151、150、149、148、147、146、145、144、143、142、141、140、139、 138、137、136、135、134、133、132、131、130、129、128、127、126、125、124、123、122、121、120、 119、118、117、116、115、114、113、112、111、110、109、 108、107、106、105、104、103、102、101、 100,99,98,97,96,95,94,93,92 or 91 degree.

Check valve the first cylindrical portion

Tip portion can be connected to the first cylindrical portion bottom it.First cylindrical portion (see for example Fig. 2 i's (120) width) can be identical with the width of tip portion (see for example (118) of Fig. 2 i) bottom.

First cylindrical portion height

The height of check valve the first cylindrical portion can be about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.Check valve first is cylindric Part height can be exceed about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.The height of check valve the first cylindrical portion can be less than About 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.The height of check valve the first cylindrical portion can be about 1 to 20mm, about 1 to 10mm, about 1mm to 7.5mm, about 1 to 5mm, about 2.5 to 20mm, about 2.5 to 10mm, about 2.5 to 7.5mm or about 2.5 to 5mm.

First cylindrical portion partial width

The diameter of the first cylindrical portion can be about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.The diameter of the first cylindrical portion can be Exceed about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.The diameter of the first cylindrical portion can be less than about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.First is cylindric Part diameter can be about 1 to 20mm, 1 to 10mm, 1 to 7.5mm, 1 to 5mm, 2.5 to 20mm, 2.5 to 10mm or 2.5 to 7.5mm。

Check valve the first shelf

Check valve can have the first shelf outwards downwardly extended from check valve (see for example (116) of Fig. 2 i) bottom (see for example Fig. 2 i (122)).First shelf may be embodied in slit or the groove regulating air mass flow when device is activated.The One shelf can be used to stop check valve in blast tube to move upward when equipment is activated.

Bottom the first cylindrical portion, the shortest length of the first shelf surfaces to the second cylindrical portion top is permissible About 0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8, 1.9、2.0、2.1、2.2、2.3、2.4、2.5、2.6、2.7、2.8、2.9、3.0、3.1、3.2、3.3、3.4、3.5、3.6、3.7、 3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9 or 5mm.To bottom the first cylindrical portion The shortest length of first shelf surfaces at two cylindrical portion tops can be exceed about 0.1,0.2,0.3,0.4,0.5,0.6, 0.7、0.8、0.9、1.0、1.1、1.2、1.3、1.4、1.5、1.6、1.7、1.8、1.9、2.0、2.1、2.2、2.3、2.4、2.5、 2.6、2.7、2.8、2.9、3.0、3.1、3.2、3.3、3.4、3.5、3.6、3.7、3.8、3.9、4.0、4.1、4.2、4.3、4.4、 4.5,4.6,4.7,4.8,4.9 or 5mm.To the first shelf table at the second cylindrical portion top bottom the first cylindrical portion The shortest length in face can be less than about 0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3, 1.4、1.5、1.6、1.7、1.8、1.9、2.0、2.1、2.2、2.3、2.4、2.5、2.6、2.7、2.8、2.9、3.0、3.1、3.2、 3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9 or 5mm.From Bottom one cylindrical portion the shortest length of the first shelf surfaces to the second cylindrical portion top can be about 0.1 to 5mm, 0.1 to 4mm, 0.1 to 3mm, 0.1 to 2mm, 0.1 to 1.75mm, 0.1 to 1.5mm, 0.1 to 1.25mm or 0.1 to 1mm.

Between side and the surface of the first shelf of the first cylindrical portion formed angle can be about 91 to 179 degree, Between 100 to 170 degree, 110 degree to 160 degree, 120 degree to 150 degree or 130 to 140 degree.The side of the first cylindrical portion and The angle formed between the surface of one shelf can be about 179,178,177,176,175,174,173,172,171,170, 169、168、167、166、165、164、163、162、161、160、159、158、157、156、155、154、153、152、151、 150、149、148、147、146、145、144、143、142、141、140、139、138、137、136、135、134、133、132、 131、130、129、128、127、126、125、124、123、122、121、120、119、118、117、116、115、114、113、 112,111,110,109,108,107,106,105,104,103,102,101,100,99,98,97,96,95,94,93,92 or 91 degree.The angle formed between side and the surface of the first shelf of the first cylindrical portion may be greater than about 179,178, 177、176、175、174、173、172、171、170、169、168、167、166、165、164、163、162、161、160、159、 158、157、156、155、154、153、152、151、150、149、148、147、146、145、144、143、142、141、140、 139、138、137、136、135、134、133、132、131、130、129、128、127、126、125、124、123、122、121、 120、119、118、117、116、115、114、113、112、111、110、109、108、107、106、105、104、103、102、 101,100,99,98,97,96,95,94,93,92 or 91 degree.The side of the first cylindrical portion and the surface of the first shelf it Between the angle that formed can be less than about 179,178,177,176,175,174,173,172,171,170,169,168,167, 166、165、164、163、162、161、160、159、158、157、156、155、154、153、152、151、150、149、148、 147、146、145、144、143、142、141、140、139、138、137、136、135、134、133、132、131、130、129、 128、127、126、125、124、123、122、121、120、119、118、117、116、115、114、113、112、111、110、 109,108,107,106,105,104,103,102,101,100,99,98,97,96,95,94,93,92 or 91 degree.First circle The angle formed between side and the surface of the first shelf of barrel can be obtuse angle.

First shelf is relative to the size of blast tube

First shelf can be configured to as having more broader diameter than blast tube internal diameter.First shelf can be configured to for The bottom of contact nozzle when device is activated.First shelf can be configured to as preventing whole check valve when device is activated Enter blast tube.First shelf can be configured to as preventing powdered treatment preparation in manual air pump when device is activated (such as flexible bladder) upstream moves.

The slit of the first shelf or groove

First shelf can have one or more slit or groove on shelf surfaces.Slit can be activated at device The air from manual air pump to nozzle is allowed to flow time (such as, by compression).One or more slits can be used for working as device (such as enter into powdered treatment preparation storage chamber when air from air source) when being activated device storage chamber and produce eddy current.Produced Raw eddy current can realize the delivery completely of powdered treatment preparation.Slit or groove can be positioned so that the laminar flow allowed in storage chamber Air-flow.

Gap or the length of groove

Slit or groove (for example, with reference to, Fig. 2 i (128)) can be at check valves (for example, with reference to, Fig. 2 i (116)) first Prolong from the first cylindrical portion (for example, with reference to, Fig. 2 i (120)) bottom on the surface of shelf (for example, with reference to, Fig. 2 i (122)) Reach the top of the second cylindrical portion (for example, with reference to, Fig. 2 i (124)).Slit or groove can be on the first shelf surfaces Extend about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26, 27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、49、50、51、 52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、72、73、74、75、76、 77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99 or 100% Bottom the first cylindrical portion to the shortest length at the second cylindrical portion top.Slit or groove can be at the first shelves Extend beyond about 1 on surface, 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23, 24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、 49、50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、72、73、 74、75、76、77、78、79、80、81、82、83、84、85、86、87、88、89、90、91、92、93、94、95、96、97、98、 99 or 100% bottom the first cylindrical portion to the second cylindrical portion top shortest length.Slit or groove can be Extend less than about 1 on first shelf surfaces, 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20, 21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、 46、47、48、49、50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、 71、72、73、74、75、76、77、78、79、80、81、82、83、84、85、86、87、88、89、90、91、92、93、94、95、 96,97,98,99 or 100% bottom the first cylindrical portion to the shortest length at the second cylindrical portion top.Slit Or groove can extend on the first shelf surfaces about 1-100%, 10-100%, 20-100%, 30-100%, 40-100%, 50-100%, 60-100%, 70-100%, 80-100% or 90-100% bottom the first cylindrical portion to the second cylinder The shortest length of shape atop part.

SlitOr the angle of groove

Slit or groove are relative to representing on the first shelf surfaces bottom the first cylindrical portion to the second cylindrical portion The straight line of point top shortest length becomes an angle of 90 degrees or non-90-degree angle.Slit or groove are relative to representing on the first shelf surfaces from Bottom one cylindrical portion straight line to the second cylindrical portion top shortest length can become about 0 to 90 degree, 5 to 90 degree, 10 To 80 degree, 15 degree to 75 degree, 20 to 70 degree, 25 to 65 degree, 30 degree to 60 degree, 35 degree to 55 degree or the angle of 40 to 50 degree.Narrow Seam or groove are the shortest to the second cylindrical portion top relative to representing on the first shelf surfaces bottom the first cylindrical portion The straight line of length can become about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22, 23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、 48、49、50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、72、 73, the angle of 74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89 or 90 degree.Slit or groove are relative Yu represents on the first shelf surfaces permissible to the line of the second cylindrical portion top shortest length bottom the first cylindrical portion Become greater than about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25, 26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、49、50、 51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、72、73、74、75、 76, the angle of 77,78,79,80,81,82,83,84,85,86,87,88 or 89 degree.Slit or groove are put relative to representing first On frame surface bottom the first cylindrical portion straight line to the second cylindrical portion top shortest length can become less than about 1, 2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、 30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、49、50、51、52、53、54、 55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、72、73、74、75、76、77、78、79、 80, the angle of 81,82,83,84,85,86,87,88,89 or 90 degree.When one or more slits are (parallel the angle of 0 degree Yu represents on the first shelf surfaces bottom the first cylindrical portion to the line of the second cylindrical portion top shortest length), empty Gas can along storage chamber wall straight flowing.When slit is in the angle more than 0 degree and less than 90 degree, can produce along storage chamber wall Eddy current, can make medicine be delivered out storage chamber completely.

Slit or depth of groove

The depth capacity of slit or groove can be gap or the 1 of groove length, 2,3,4,5,6,7,8,9,10,11,12, 13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、 38、39、40、41、42、43、44、45、46、47、48、49、50、51、52、53、54、55、56、57、58、59、60、61、62、 63、64、65、66、67、68、69、70、71、72、73、74、75、76、77、78、79、80、81、82、83、84、85、86、87、 88,89,90,91,92,93,94,95,96,97,98,99 or 100%.The depth capacity of slit or groove can exceed gap Or about the 1 of groove length, 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24, 25、26、27、28、29、30、 31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、49、 50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、72、73、74、 75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99 or 100%.The depth capacity of slit or groove can less than gap or about the 1 of groove length, 2,3,4,5,6,7,8,9,10,11, 12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、 37、38、39、40、41、42、43、44、45、46、47、48、49、50、51、52、53、54、55、56、57、58、59、60、61、 62、63、64、65、66、67、68、69、70、71、72、73、74、75、76、77、78、79、80、81、82、83、84、85、86、 87,88,89,90,91,92,93,94,95,96,97,98,99 or 100%.The depth capacity of slit or groove can be gap Or about the 1 to 50% of groove length, 1 to 40%, 1 to 30%, 1 to 25%, 1 to 20%, 1 to 15%, 1 to 10%, 1 to 5% Or 1 to 2.5%.

Slit or groove shapes

Slit or groove can be by curved surface (such as semicircles；See for example Fig. 2 iv), two surfaces (see for example figure 2v), three surfaces (see for example Fig. 2 vi), four surfaces, five surfaces, six surfaces, seven surfaces, eight surfaces, nine tables Face or ten surfaces are formed.First shelf can have and have at least 1,2,3,4,5,6,7,8,9 or 10 kind of difform slit Or groove.

Gap or groove number

Check valve the first shelf can have at least 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17, 18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、 43、44、45、46、47、48、49、50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、 68、69、70、71、72、73、74、75、76、77、78、79、80、81、82、83、84、85、86、87、88、89、90、91、92、 93,94,95,96,97,98,99 or 100 slits or grooves.Check valve the first shelf can have less than 1,2,3,4,5,6,7, 8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、 34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、49、50、51、52、53、54、55、56、57、58、 59、60、61、62、63、64、65、66、67、68、69、70、71、72、73、74、75、76、77、78、79、80、81、82、83、 84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99 or 100 slits or grooves.Check valve first is put Frame can have about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25, 26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、49、50、 51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、72、73、74、75、 76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99 or 100 Individual slit or groove.Check valve the first shelf have about 1-100,1-90,1-80,1-70,1-60,1-50,1-40,1-30,1-25, 1-20 or 1-10 slit or groove.

Slit or groove location

When the first shelf has more than one slit or groove, slit or groove can be substantially parallel to one another.At some In embodiment, not every slit or groove part are substantially parallel to one another.In certain embodiments, not all slit or recessed Groove is the most spaced apart on the first shelf.In certain embodiments, all of slit or groove are uniform on the first shelf Spaced apart.

Second cylindrical portion

Check valve can have second cylindrical portion (see, e.g., Fig. 2 i (124)) below the first shelf.

Second cylindrical portion height

The height of check valve the second cylindrical portion can be more longer than the height of the first cylindrical portion.Check valve the second circle The height of barrel can be more shorter than the height of the first cylindrical portion.The height of check valve the second cylindrical portion is permissible Be about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.The height of check valve the first cylindrical portion may be greater than about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm. The height of check valve the first cylindrical portion can be less than about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.Check valve the first cylindrical portion Height can be about 1 to 20mm, about 1 to 10mm, about 1mm to 7.5mm, about 1 to 5mm, about 1 to 4mm, about 1 to 3mm or about 1 To 2mm.

Second cylindrical portion partial width

Check valve the second cylindrical portion can be more wider than check valve the first cylindrical portion.Check valve the second cylindrical portion Dividing can be more wider than blast tube internal diameter.Check valve the second cylindrical portion can be more narrower than blast tube internal diameter.

The diameter of the second cylindrical portion can be about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.The diameter of the second cylindrical portion can be Exceed about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.The diameter of the second cylindrical portion can be less than about 1mm, 2mm, 3mm, 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm, 16mm, 17mm, 18mm, 19mm or 20mm.Second cylinder Shape part can be about 1 to 20mm, 1 to 10mm, 1 to 7.5mm, 1 to 5mm, 2.5 to 20mm, 2.5 to 10mm or 2.5 to 7.5mm。

In some embodiments, check valve the second cylindrical portion comprises spine's (see, e.g., Fig. 5 (444)).When Equipment is not activated, and spine can be still on the protuberance (such as, Fig. 5 (446)) of blast tube.Such location is possible to prevent Check valve is upstream manoeuvred into manual air pump.Such location is also possible to prevent powdered treatment preparation and upwards vacillates Move and enter into manual air pump.The combination of spine and the second cylindrical portion can be more wider than the width of the second cylindrical portion. Spine can be located in the optional position of the length along the second cylindrical portion.Spine can be formed around the second cylindrical portion Some or all of ring.Protuberance can be any one in various shape or size.

Second shelf

Check valve can have the bottom from the second cylindrical portion (see, e.g., Fig. 2 i (126)) inwardly and downwardly to extend The second shelf.Second shelf can be arranged to cover the flow export of manual air pump when hand air pump is uncompressed, in case Only powdered treatment preparation upstream moves into manual air pump.

Second shelf length

Bottom the second cylindrical portion shortest length to the second shelf surfaces bottom check valve can be about 0.1, 0.2、0.3、0.4、0.5、0.6、0.7、0.8、0.9、1.0、1.1、1.2、1.3、1.4、1.5、1.6、1.7、1.8、1.9、2.0、 2.1、2.2、2.3、2.4、2.5、2.6、2.7、2.8、2.9、3.0、3.1、3.2、3.3、3.4、3.5、3.6、3.7、3.8、3.9、 4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9 or 5mm.To bottom check valve bottom the second cylindrical portion The shortest length of the second shelf surfaces can be exceed about 0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0, 1.1、1.2、1.3、1.4、1.5、1.6、1.7、1.8、1.9、2.0、2.1、2.2、2.3、2.4、2.5、2.6、2.7、2.8、2.9、 3.0、3.1、3.2、3.3、3.4、3.5、3.6、3.7、3.8、3.9、4.0、4.1、4.2、4.3、4.4、4.5、4.6、4.7、4.8、 4.9 or 5mm.Bottom the second cylindrical portion, the shortest length to the second shelf surfaces bottom check valve can be less than about 0.1、0.2、0.3、0.4、0.5、0.6、0.7、0.8、0.9、1.0、1.1、1.2、1.3、1.4、1.5、1.6、1.7、1.8、1.9、 2.0、2.1、2.2、2.3、2.4、2.5、2.6、2.7、2.8、2.9、3.0、3.1、3.2、3.3、3.4、3.5、3.6、3.7、3.8、 3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9 or 5mm.To check valve bottom the second cylindrical portion The shortest length of the second shelf surfaces of bottom be about 0.1 to 5mm, 0.1 to 4mm, 0.1 to 3mm, 0.1 to 2mm, 0.1 to 1.75mm, 0.1 to 1.5mm, 0.1 to 1.25mm or 0.1 to 1mm.

Second shelf angle

Between second cylindrical portion side and the second shelf surfaces formed angle can be about 0 to 90 degree, 10 degree extremely 80 degree, 20 to 70 degree, 30 degree to 60 degree or 40 degree to 50 degree.Formed between second cylindrical portion side and the second shelf surfaces Angle can be about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24, 25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、49、 50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、72、73、74、 75,76,77,78,79,80,81,82,83,84,85,86,87,88,89 or 90 degree.Second cylindrical portion side and second is put The angle formed between frame surface can exceed about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18, 19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、 44、45、46、47、48、49、50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、 69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89 or 90 degree.Second cylinder The angle formed between shape surface and the second shelf surfaces can be less than about 1,2,3,4,5,6,7,8,9,10,11,12, 13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、 38、39、40、41、42、43、44、45、46、47、48、49、50、51、52、53、54、55、56、57、58、59、60、61、62、 63、64、65、66、67、68、69、70、71、72、73、74、75、76、77、78、79、80、81、82、83、84、85、86、87、 88,89 or 90 degree.The angle formed between second cylindrical portion side and the second shelf surfaces can be acute angle or right angle.

Bottom check valve

Check valve can be configured to as having than the second cylindrical portion (see, e.g., figure (426)) width broader end Portion.In some embodiments, when being activated when device or be not activated when device, bottom not contact nozzle pipe.

Selectable configuration

In some embodiments, check valve has top section, the first cylindrical portion, the first shelf, the second cylinder Shape part and the second shelf or bottom.In other embodiments, check valve need not have all these part.Such as, single Can be formed to be still at its inactive position independent cylinder or other shapes of bottle throat to valve, and be positioned at nozzle shoulder Below portion.Check valve can have one or more passage blocked by bottle throat when check valve is still in bottle throat or narrow Seam.When manual pump is compressed, check valve can be pushed upwardly in its activation position and prop up nozzle shoulder, and when air can flow Cross one or more passage not blocked by nozzle shoulder or slit and enter nozzle.

Check valve can have any shape, its with one or more check valve can be allowed to be still in bottle throat and not The part of bottle can be fallen into.Check valve can have with one or more that check valve can be allowed to move upward is limited when activating Measure any shape of the part to the second position.In some embodiments, check valve is takeed on by nozzle in it moves upward Other shape facilities of portion or nozzle are restricted.This check valve can have one or more when check valve is at inactive position The fluid flowing passage (such as, slit, passage, groove, tunnel, pipe) not being in fluid communication with air or gas source.Real at some Execute in mode, fluid flowing passage is directly blocked by nozzle shoulder, or fluid communication is still in the check valve of bottle shoulder A part is blocked.Fluid flowing passage can be when check valve is in activation position between air or gas source and nozzle interior Fluid communication is provided.Fluid flowing passage can be positioned so that as being in activation or during un-activated position not by nozzle when check valve Shoulder blocks.

Non-return valve operational

Check valve can be set to take primary importance in a device and the second position (such as, comparison diagram 1 and figure 3).In some embodiments, first position is closed construction, and it is possible to prevent the air from air source to flow, and In some embodiments, by flow export and/or throat.In some embodiments, primary importance prevents air further Flow nozzle and/or powdered treatment agent storage chamber.In some embodiments, the movable valve in primary importance is configured to make Air can not flow out and treat preparation and can not enter into air source from storage chamber flow upstream from flow export.Real at some Executing in mode, the check valve in primary importance connects so that air can not flow into air from flow export with flow export Source.In some embodiments, check valve is maintained at primary importance by gravity.Selectively, check valve can be by by partially The power of putting is maintained at primary importance.Bias force can be provided by compressible mechanism or tension mechanism.Bias force can pass through spring, pine Taut band, plastic foam or rubber part provide.In some embodiments, the second position of valve disc is open structure, and it is permitted Permitted to flow from the air of air source, flowed out flow export, and by gas channel and/or powdered treatment agent storage chamber.

Check valve motion from primary importance to the second position can be reversible, such as by gravity, pressure, air-flow, Control bar or spring mechanism or a combination thereof.In other embodiments, check valve movement from primary importance to the second position is Irreversible or be not easy reversible.In some embodiments, the position of check valve can be existed by air or other propellant The pressure of flow export and air or other propellant pressure differential between the pressure of storage chamber are regulated.At some embodiments In, check valve can be configured to as being maintained in the case of there is enough air mass flows from air source or flow velocity Two positions, and move to primary importance in the case of there is not enough air mass flows from air source or flow velocity.

C. air source

Device described herein can include air source.Air source can be set to provide air or other propellant or its group The air-flow closed is passed to powdered treatment preparation storage chamber, leaves nozzle and enters into nostril or the nasal cavity of experimenter.Air source can It is set to provide the air-flow flowing through the valve for regulating the air stream entering nozzle or storage chamber.

Air source can be by multiple polymers, plastics, rubber, silicones, metal, composite, applicable use described herein In manufacturing any other material of applicator or being suitable as any other material composition of applicator air source.Air source can To be made up of a kind of material or different materials.Selectively, air source can be by two or more different materials or different material Material type is formed.In some embodiments, part or all of air source can be biocompatible materials or low cause Sensitive materials.Air source can be by rigidity, or the most flexible material or its group It is combined into.In some embodiments, air source comprises one or more silicones, acrylate, polyethylene, polyurethane, gathers Urethane, hydrogel, polyester are (such as, from E.I.Du Pont de Nemours and Company, Wilmington, Del. DACRONB), polypropylene, politef (PTFE), varicosity PTFE (ePTEE), polyether-ether-ketone (PEEK), nylon, extrusion Collagen protein, polymer foams, rubber, silicone rubber, polyethylene terephthalate, ultra-high molecular weight polyethylene, Polycarbonate urethane, polyurethane, polyimides, aluminum, rustless steel, Nitinol (such as, Nitinol), titanium, stainless Steel, cochrome are (such as, from Elgin Specialty Metals, the ELGILOYB of Elgin, Ill.；From Carpenter Metals Corp., the CONICHROMEB of Wyomissing, Pa.).

Air source can be the one being suitable in the multiple air source of nose applicator, such as at U.S. Patent application US20090025720、US20090064997、US20080819617、US20080161771、US20080289629、 US20080142018、US20070129665US20060219240US20060024185US20060254585US200401878 68US20040149289US20040112378US20020174865；United States Patent (USP) US3856185, US4017007, US4200099、US5046493、US5683361、US5702362、US6488648、US6824080、US6866039、 US6938798、US6186141、US6345737、US6585172、US6543448、US6089228、US6427680、 US6644305、US6494204、US6290667、US7481218；International monopoly is asked WO2002/00282, WO2005/ 000477、WO2008/026730、WO2007/102089、WO1990/07351、WO/2003/000310；European patent EP1673123, EP1390091 and Japanese patent application JP2006122189, JP2001095918, JP3678955, JP11226127、JP3488624、JP11221280、JP11197245、JP3547605、JP10028735、JP9248342、 Air described in JP09028805, JP08322934, JP08280808, JP8206208, JP8103499 and JP8071152 Source, they are expressly incorporated herein by reference with entire contents.

Air source can be pressurizing vessel.In some embodiments, pressurizing vessel contains air or other propellant, example Such as the hydro carbons of one or more low-molecular-weights, such as butane or propane, dimethyl ether, methyl ethyl ether, nitrous oxide, titanium dioxide Carbon, nitrogen, hydrogen fluorohydrocarbon, compressed air, Chlorofluorocarbons (CFCs) or hydrofluoroalkane the most such as 1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-seven Fluoro-propane.Pressure vessel can comprise about 0.1 gram of propellant to about 5 grams of propellants, including at least about 4g, 3g, 2g, 1.5g, 1g, 0.75g, 0.5g, 0.25g, 0.2g or about 0.1 gram of propellant.Pressurizing vessel can be set to comprise maximum pressure for extremely Few about 1.5atm, 2atm, 2.5atm, 3atm, 3.5atm, 4atm, 4.5atm, 5atm, 5.5atm, 6atm, 7atm, 8atm, The propellant of 9atm, 10atm, 11atm or about 12atm.In some embodiments, pressurizing vessel can be set to comprise Maximum pressure is about 2atm to about 10atm, 3atm to about 9atm, 4atm to about 8atm, 4atm to about 7atm or about 4atm to about The propellant of 6atm.

Pressurizing vessel can be activated by any known devices in this area thus discharge propellant.Such as, pressure valve is permissible Make air source discharge propellant by applied compression power, or control bar can make air source discharge propellant by lever motion. In another embodiment, pressurizing vessel can discharge propellant by being activated in response to numeral or analogue signal.Example As, user can press the button controlling propellant release, such as by controlling servo motor or microprocessor control valve.? In some embodiments, container can be detected the mechanism activation of nasal inhalation.Such as, bar or other sensing device such as pressure are controlled Sensor, can enter experimenter nostril and the suction of experimenter by positioning device as described herein and be activated.Add Pressure vessel can be set to release control amount or the propellant of metered amount when each activation vessel.In other embodiments, Pressurizing vessel can continue to discharge propellant, until user stops providing activates input.

Air source can be the pump of such as electrodynamic pump or manual pump.Air source can comprise and is slidably disposed in outer container Inner pressurd vessel.Manually or other modes move in inside and outside container one or more outflow air source can be provided to enter Air stream to fluid passage.The inside and outside container of pump can be set to return in the case of not having external compressive force static State, the most such as by spring or the action of other gigbacks.In another embodiment, pump includes slidably living Plug.Can manually or piston driven electrically.Manually or the piston movement of other modes can provide outflow sky Source of the gas the air stream being flowed in fluid passage.Piston can be set to return to static shape in the absence of external forces State, such as by spring or the action of other gigbacks.

Pump can comprise deformable volume.Such as, pump can comprise plastics, rubber or the material of other deformation.Pump is also Radial type volume can be comprised, thus as the folding of accordion like allows compressor pump to provide air.Deformable volume can be by example As one or more fingers (between such as thumb and forefinger, middle finger, the third finger, little finger of toe) combination or by one or many The combination compression of hands.Selectively, deformable volume can be compressed by electronics or hydraulic means.In some embodiments, may be used Deformation volume is such as applied extruding or other compression stresses to compress, and returns to incompressible shape after compression stress discharges.? In some embodiments, revert to incompressible shape can by the intrinsic elastic force of shape and the shape of deformable volume and Material provides.Can assist to return by spring or other energy response agencies.

Air source can have any be suitable for device described herein shape, include but not limited to spherical, ellipsoid shape, Other suitable shape any of cylindrical shape, cubic, frustum (frustum) or any one shape the most described herein Shape or a combination thereof.The length in air source upstream to downstream can be less than about 10cm, 9cm, 8cm, 7cm, 6cm, 5cm, 4.5cm, 4cm, 3.5cm, 3cm or 2cm.In some embodiments, the length of air source can be about 2cm to 10cm, about 2cm to 8cm, About 2cm to 5cm, about 4cm to 10cm or about 4cm to 6cm.The length in air source upstream to downstream can be at least 1cm, 2cm, 3cm, 4cm, 5cm, 6cm, 7cm, 8cm, 9cm or 10cm.The length in air source upstream to downstream can be about 1cm, 2cm, 3cm, 4cm, 5cm, 6cm, 7cm, 8cm, 9cm or 10cm.

In some embodiments, air source be perpendicular to upstream to downstream shaft width its widest portion less than 1cm, 1.5cm, 2cm, 2.5cm, 3cm, 3.5cm, 4cm, 4.5cm, 5cm, 6cm, 7cm, 8cm, 9cm, 10cm, 12cm, 15cm or 20cm Wide.To source of the gas be perpendicular to upstream to downstream shaft width its widest portion be at least 1cm, 1.5cm, 2cm, 2.5cm, 3cm, 3.5cm, 4cm, 4.5cm, 5cm, 6cm, 7cm, 8cm, 9cm, 10cm, 12cm, 15cm or 20cm width.Air source is perpendicular to upstream extremely The width of downstream shaft its widest portion can be 1cm, 1.5cm, 2cm, 2.5cm, 3cm, 3.5cm, 4cm, 4.5cm, 5cm, 6cm, 7cm, 8cm, 9cm, 10cm, 12cm, 15cm or 20cm width.

In some embodiments, air source has less than 10cm³、9cm³、8cm³、7cm³、6cm³、5cm³、4cm³、3cm³、 2cm³, or 1cm³Volume.In some embodiments, air source includes about 1cm³To about 10cm³, or about 2cm³To about 10cm³、 2cm³To about 7cm³, or 4cm³To about 8cm³Volume.Air source can have more than 10cm³、9cm³、8cm³、7cm³、6cm³、 5cm³、4cm³、cm³、2cm³, or 1cm³Volume.Air source can have about 10cm³、9cm³、8cm³、7cm³、6cm、5cm³、 4cm³、3cm³、2cm³, or 1cm³Volume.

Air source can be set to during once activating deliver about 1mL to the air of about 10mL or other propellant extremely The nostril of experimenter.Air source can be set to once activate during deliver about 1mL to the air of about 10mL or other push away Enter agent to the powdered treatment preparation storage chamber of device.In some embodiments, air source can be set to deliver at least The air of 1mL, 2mL, 3mL, 4mL, 5mL, 6mL, 7mL, 8mL, 9mL or 10mL or other propellants are to the nostril of experimenter or dress The storage chamber put.In some cases, air source can be set to deliver at least 1mL to 10mL, 1mL to 8mL, 1mL to 5mL, The air of 2mL to 10mL, 2mL to 8mL, 2mL to 7mL, 2mL to 6mL, 2mL to 5mL, 3mL to 10mL or 3mL to 8mL or other The propellant nostril to experimenter or the storage chamber of device.Air source can be set to deliver less than 1mL, 2mL, 3mL, 4mL, Nostril to experimenter of the air of 5mL, 6mL, 7mL, 8mL, 9mL or 10mL or other propellant or the storage chamber of device.Air source Can be set to deliver the air of about 1mL, 2mL, 3mL, 4mL, 5mL, 6mL, 7mL, 8mL, 9mL or 10mL or other propellant Nostril or the storage chamber of device to experimenter.Air source can be set to be activated by the power of about 5kPa to 100kPa.Air Source can be set to by less than about 5kPa, 6kPa, 7kPa, 8kPa, 9kPa, 10kPa, 11kPa, 12kPa, 13kPa, 14kPa, 15kPa、16kPa、17kPa、18kPa、19kPa、20kPa、21kPa、22kPa、23kPa、24kPa、25kPa、26kPa、 The power institute of 28kPa, 30kPa, 32kPa, 33kPa, 35kPa, 38kPa, 40kPa, 42kPa, 45kPa, 48kPa or 50kPa pressure Activate.Air source can be set to provide air or other propellant pressures at flow export about 1kPa to about 100kPa, about 2kPa is to about 50kPa, about 4kPa to about 40kPa, about 5kPa to about 35kPa or about 10 to about 30kPa.

Inflow entrance

Air source could be included for the inflow entrance using air or other propellant to fill air source.In some embodiments In, inflow entrance connects with air source and connects with external environment condition.Inflow entrance can comprise further for regulation pass through inflow entrance The valve of air stream or other device.In certain embodiments, inflow entrance can be set to provide outside air source towards One-way air stream within air source.In some embodiments, inflow entrance is set to provide from by applied compression power institute The air source compressed format provided and the movement of the uncompressed form of air source provided by release compression stress.Such as, hands is passed through Dynamic extruding air source applied compression power can provide from air source through flow export the air movement of final mass flowing nozzle, same Time, release compression stress provides the air movement being entered air source by inflow entrance, and it partly or entirely provides non-compressed state The compensation of air source.

Inflow entrance can be any one of various shape, includes, but are not limited to, coniform, cylindric, taper cone barrel, truncate Head body and parallelepiped or other shape any provided in this article, comprise the group of one or more shapes provided in this article Close.In some embodiments, width or the diameter of inflow entrance is associated with width or the diameter of flow export.Such as, inflow entrance Width or diameter can be set to be less than flow export width or the 1% of diameter, 2%, 2%, 4%, 5%, 6%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80% or 90%.At some In the case of, the size of inflow entrance is associated with the size of flow export.Such as, the size of inflow entrance can be set to exceed outflow Mouthful the 1% of size, 2%, 3%, 4%, 5%, 6%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80% or 90%.

Inflow entrance diameter can be about 0.05 to 2 millimeter, about 0.05 millimeter to 1 millimeter, about 0.05 millimeter to 0.5 millimeter, About 0.05 millimeter to 0.1 millimeter.The diameter of inflow entrance can be about 0.05,0.06,0.07,0.08,0.09,0.1,0.15, 0.2、0.25、0.3、0.35、0.4、0.45、0.5、0.55、0.6、0.65、0.7、0.75、0.8、0.85、0.9、1、1.1、1.2、 1.3,1.4,1.5,1.6,1.7,1.8,1.9 and 2 millimeters.The diameter of inflow entrance can be exceed about 0.05,0.06,0.07, 0.08、0.09、0.1、0.15、0.2、0.25、0.3、0.35、0.4、0.45、0.5、0.55、0.6、0.65、0.7、0.75、0.8、 0.85,0.9,1,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9 and 2 millimeters.The diameter of inflow entrance can be less than About 0.05,0.06,0.07,0.08,0.09,0.1,0.15,0.2,0.25,0.3,0.35,0.4,0.45,0.5,0.55,0.6, 0.65,0.7,0.75,0.8,0.85,0.9,1,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9 and 2 millimeters.

Inflow entrance can be in air source.Inflow entrance may be located at air source throat.In certain embodiments, nozzle bore is also It can be inflow entrance.

Flow export

Flow export can be set to provide at about 1kPa to about 100kPa, about 2kPa to about 50kPa, about 4kPa to about 40kPa or about 5kPa are to the pressure between about 35kPa.Flow export can be any one shape in various shape, including but also It is not limited to, coniform, cylindric, taper cone barrel, frustum and parallelepiped or other shape any provided in this article, bag Combination containing one or more shapes.

In some embodiments, the length in flow export upstream to downstream is less than about 20mm, less than about 15mm, is less than about 10mm, less than about 8mm, less than about 7mm, less than about 6mm, less than about 5mm, less than about 4mm or less than about 3mm.At some In embodiment, the length of flow export is about 3mm to 20mm, about 3mm to 15mm, about 3mm to 10mm or at about 5mm to 10mm. Flow export can be about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24, 25,26,27,28,29 or the length of 30mm.In some embodiments, flow export is perpendicular to upstream to the width of downstream shaft and exists Its widest portion is about 5mm to about 20mm or about 5mm to 15mm.In some embodiments, flow export be perpendicular to upstream under Trip axle width its widest portion be at least about 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm or 20mm width.In some embodiments, flow export is perpendicular to upstream to the width of downstream shaft is little in its narrowest part In about 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm, 13mm, 14mm, 15mm or 20mm width.Flow export is vertical In upstream to downstream shaft width its widest portion can be about 4mm, 5mm, 6mm, 7mm, 8mm, 9mm, 10mm, 11mm, 12mm、13mm、14mm、15mm、16mm、17mm、18mm、19mm、20mm、21mm、22mm、23mm、24mm、25mm、26mm、 27mm, 28mm, 29mm or 30mm.

Check valve for airtight equipment

In some embodiments, check valve can be configured to for minimize or prevent powder formulation be exposed to air and In dampness, thus, it is possible to when device do not comprise air intake or when device is closed system increase be pre-filled in device or The stability of the powder formulation in storage chamber.Valve can be prepared by the manufacture method of device feature more simplified and can be caused more preferably Cost benefit.

Valve can be check valve for powder formulation, can be two-way valve for air.Valve can be set to allow from Powdered treatment preparation air in nozzle release and permission pump from nozzle release and allows air from external environment condition warp Crossing nozzle to enter, this is so that air enters pump.This can allow reconditioning device and without having inflow entrance on device pump.

In some embodiments, device can be gas-tight container or closed system.Such as when removable or can crushing lid When son is in place or is not removed, the most such as, on pump, can there is no entrance or hole.In some embodiments, pump is not Comprise air intake.The device (as mentioned above) comprising air intake on pump can contact extraneous air.When pump in a device After being activated, air can be escaped from device by the air intake of pump.Between pumped current from pump the air loss of air intake Can cause less than for from device discharge therapeutic agent from the maximum air capacity in pump.There is no the dress of air intake on pump In putting, do not exist by air intake air from pump internal loss to environment.Air loss energy in pump is stoped between pumped current The maximum amount of air in pump is made to be used for from device discharging therapeutic agent.In some embodiments, do not having on pump In the device of air intake, the whole air being extruded pump by the activation of pump can be for advancing treatment preparation.Compared on pump Having the device of air intake, the design of (not having air intake on pump) device can reduce pump volume and obtain less device. Compared to having the device of air intake on pump, pump there is no pump volume size and the dress of minimizing of the minimizing of atmospheric gas inlet unit Put size to reduce manufacturing cost and increase portability.

In some embodiments, when the removable lid that maybe can crush is in place or when not being removed, do not exist and air source Or the connection of external environment condition.In some embodiments, when removable maybe can crush lid be removed time, device can comprise stream Entrance.In some embodiments, when removable maybe can crush lid be removed time, inflow entrance can comprise jet hole.Nozzle Hole (inflow entrance) can be to be suitably for allowing powdered treatment preparation to discharge from nozzle with the form of single logistics.Implement at some In mode, nozzle has multiple hole (inflow entrance), can be as the most separate multiple logistics or permissible when device is activated It is merged into a single logistics to discharge powdered treatment preparation.In some embodiments, nozzle bore is placed in nozzle downstream End.In some embodiments, nozzle bore is also downstream end.Nozzle bore can be any one in various shape, bag Contain but be not limited to circle, ellipse, triangle, rectangle or a combination thereof.

In some embodiments, check valve be set to block (such as, passing through gravity) powdered treatment preparation is upwards Roam all around the would to motion (such as, enter air source).Check valve can be set to (such as, the air source when device is not activated When not being activated) it is a position, and when a device is activated (when such as air source is activated) its in another position. Check valve is set to when device is not activated (such as, manual air pump is uncompressed) or when a device is activated (such as, When manual air pump is compressed) block in (such as, passing through gravity) powdered treatment preparation upstream direction and (such as, to enter soft Property bottle and/or air pump) motion.

Check valve can be set to regulate the air stream entering device nozzle from air source.Check valve can further by It is set as regulating the motion of powdered treatment preparation.Check valve can be set to when device is not activated (such as, manually empty Air pump is uncompressed) block air or air-flow and enter nozzle, and (such as, manual air when a device is activated from air source Pump is compressed) allow air or air-flow to enter nozzle from air source.

In some embodiments, check valve can be set to when device is just in deexcitation that (such as, manual air pump is just When released) allow air to enter updrift side (such as, enter flexible bladder and/or manual air pump) from external environment condition, And when a device is activated (such as, manual air pump is compressed) time allow air into the motion of downstream direction.Going of pump Compression can draw air into nozzle storage chamber and through valve pocket entrance pump from external environment condition by nozzle bore (such as, inflow entrance).

In some embodiments, nozzle bore (inflow entrance) can be set to provide outside air source to inside air source And to the two-way airflow outside air source inside air source.In some embodiments, nozzle bore or inflow entrance are set For providing the uncompressed form of air source that the air source compressed format formed from applied compression power is formed to release compression stress Motion.Such as, manually extruding air source applied compression power can provide from air source by inflow entrance and final outflow The air movement of nozzle.The release of compression stress can provide and enter air via inflow entrance (nozzle bore) by valve pocket and flow export The air movement in source, it makes air source partly or entirely return back to non-compressed state.Such as, when compression stress is released, air Be moved into air source (such as pump) from external environment condition via nozzle bore (inflow entrance), enter nozzle storage chamber, through inner chamber across The more chamber of valve, and enter air source.

Check valve can comprise slit relative to device inclined main axes (or passage or groove), and it can swashed when device Eddy current is produced along storage chamber wall when living.

Device described herein is by being more fully understood with reference to figures provided herein.Fig. 9 illustrates once Property the sectional view of intranasal delivery device that uses.Intranasal delivery device (900) can comprise air source, and it can be flexible bladder (902).Flexible bladder can play the function of manual air pump (904).Flexible bladder can comprise flow export (906) and when moving Inflow entrance is not comprised except maybe crushing when lid (934) is not removed.Inflow entrance can comprise maybe can crush lid when removable (934) nozzle bore (932) of inflow entrance it is used as when being removed.Flexible bladder can comprise the throat being positioned at flexible bladder top (908), it has the diameter more narrower than flexible bladder (910) bottom.Throat (908) could be included for connecting nozzle (914) External screw thread (912).

Check valve (916) may be located at the surface of flexible bladder (902) throat (908), and when device is not activated (such as, being uncompressed when manual air pump) blocks flow export (906).Check valve be still in throat surface can when device not Powdered treatment preparation (M) is stoped to enter flexible bladder (902) when being activated.

Check valve (916) can comprise interior intake section (944), valve pocket (946), tip portion (918), the first cylindrical shape Partly (920), the first shelf (922), the second cylindrical portion (924) and the second shelf (926).In some embodiments, Tip portion comprises interior intake section.In some embodiments, valve does not comprise tip portion.One or more slits (928) Can be on the first shelf surfaces.One or more slits (928) can allow when manual air pump (904) is compressed (see, Such as Figure 11) air or gas flows to nozzle bore (914) from flexible bladder (902).The embodiment of check valve (916) is retouched It is set forth in Figure 10.

Intranasal device (900) can comprise nozzle (914) further, and it can include can being inserted into or be inserted partially into tested The blast tube (930) in person's nasal cavity or nostril.Nozzle (914) can comprise further removable maybe can crush lid (934), nozzle Hole (932), it can be as inflow entrance and powdered treatment preparation storage chamber when lid is removed removable maybe can crushing (938).Powdered treatment preparation storage chamber can comprise powdered treatment preparation (M).Nozzle (914) can comprise bottom (940), its energy Comprise the female thread (942) for being connected to flexible bladder (902) throat (908).Nozzle bottom female thread can be with bottle throat External screw thread match.

Figure 10 illustrates the view of the different embodiment of the check valve (916) corresponding to check valve shown in Fig. 9 (916).Figure 10i illustrates check valve (916) side view of sensing left, check valve top.In this embodiment, in check valve comprises Intake section (944), valve pocket (946), from interior intake section (944) bottom extend tip portion (918), from tip portion (918) the first cylindrical portion (920) that bottom extends.It is from the first cylindrical portion bottom the first cylindrical portion (922) the first shelf (922) outwards downwardly extended.Shown therein is the single slit on the first shelf (922) , and slit becomes non-90-degree angle relative to slit any side (928).First shelf can have multiple slit.Interior intake section (944) top of tip portion can be connected to.Interior intake section (944) can comprise and powdered treatment preparation storage chamber (938) opening being connected.In some embodiments, interior intake section (944) can be hollow.At some embodiment In, interior intake section (944) can comprise a part for valve pocket (946).The end of tip portion, can be connected to the first shelf (922) top.The bottom of the first shelf can be connected to the top of the second barrel (924).Second cylindrical portion Bottom can be connected to the second shelf (926) that can extend inwardly downward relative to the bottom of the second barrel (924).At certain In a little embodiments, check valve can be integrally formed as single part.Such as, tip portion, the first cylindrical portion, first Shelf, the second cylindrical portion and the second shelf can be integrally formed as single part.Selectively, of check valve Or some can be separately formed.

In some embodiments, interior intake section (944) forms valve pocket (946) top (upstream portion).Valve pocket is permissible Comprise two openings.Two openings can comprise upstream open and downstream opening.In some embodiments, upstream open with Powdered treatment preparation storage chamber (938) is connected.Downstream opening is connected with pump (904) in some embodiments.At some In embodiment, upstream open upstream extends into valve and forms valve pocket (946), and it can extend through valve to the second upstream open And enter pump.Valve pocket can intake section (944) downstream opening extend logical in being connected to powdered treatment preparation storage chamber (938) Cross valve to the downstream opening connecting pump.Valve pocket can connect two openings thus forms hollow space in valve and can allow air Two-way circulate and pass through.Valve pocket can be formed by valve tip portion, first and the second shelf, and first and second is cylindric The hollow space of part, thus form through contiguous chamber therein.In some embodiments, valve pocket is from interior intake section (944) opening extends, and extends and form hollow channel or the chamber being entered into manual air pump (904) by the whole length of valve. Interior intake section described herein is not limited to specific shape.Interior intake section can be uniform width such as cylindrical shape, cube Shape, rhombohedron shape or the shape of parallelepiped-shaped.Interior intake section can also be to have wide end and the funnel-form of narrow end or flat Frutum shape.Interior intake section shape can be wider at upstream extremity and narrower in downstream.Interior intake section can be under Trip end is wider and narrower at upstream extremity.

Figure 10 ii illustrates along Fig. 2 i midplane AA unidirectional looked over from the right of check valve (916) shown in Figure 10 i Valve sectional view.Cross sectional view show is corresponding to multiple recesses (928) around check valve the first shelf edge of slit (928). It can be hollow that middle circle (936) illustrates check valve (916).In some embodiments, check valve can be real The heart.In other embodiments, check valve is not hollow.

Figure 10 iii illustrates the sectional view along Figure 10 i plane BB looked over from check valve lower left shown in Figure 10 i. Illustrate slit (928).

Figure 10 iv-10vi illustrates the check valve along Figure 10 i plane AA looked on the right side of check valve shown in Figure 10 i The sectional view of a part.Illustrate the different geometries of the slit that may be formed at Figure 10 i check valve tip portion.In view narrow The geometry of seam can be by curved surface (Figure 10 iv), two surfaces (Figure 10 v), or three surfaces (Figure 10 vi) are formed.Narrow Seam sectional view geometry can be bending, angled or a combination thereof.

Figure 11 i illustrates the activation structure of the intranasal delivery device that Fig. 9 shows, and air or gas are from manual pump (904) to the stream of nozzle (914).Figure 11 ii illustrates the deexcitation structure of the intranasal delivery device that Fig. 9 shows, Yi Jikong Gas or gas enter powdered treatment preparation storage chamber (938) from external environment condition by nozzle bore (932), through interior intake section (944), through valve pocket (946), and entrance is the stream of manual air pump (904).Removable maybe can crush lid (934) by from Intranasal delivery device (900) removes.Check valve (916) can be still in bottle throat (908) surface.In order to activate device, User compression be used as manual air pump (904) flexible bladder (902) (by arrow and relative to Fig. 9 bottle deformation soft Property bottle illustrates compression).Air flows out the flow export (906) of flexible bladder (902).Air conductance causes check valve (916) and exists Rise in nozzle (914).When check valve (916) rises in nozzle, it is no longer still in bottle throat (908).Unidirectional Valve the first shelf (922) non-slit part contact blast tube (930) is soft to prevent powdered treatment preparation to be traveling upstream into Property bottle (902).Air is along check valve (916) second shelf (926) and check valve (916) second cylindrical portion (924) Advance and flow into check valve (916) first shelf (922) slit (928).Then air is in the first cylindrical portion (920) and spray Flow into storage chamber (938) between mouth pipe (930), and force powdered treatment preparation (M) rise through blast tube (930) and Mass flowing nozzle hole (932).Air is advanced also by valve pocket (946) and enters storage chamber (938).After activating device, then pump is loose Open.By unclamping pump, air is sucked and is entered storage chamber (938) by nozzle bore (inflow entrance) from external environment condition.Air flows The opening of intake section enter into pump by valve pocket and by valve pocket the second opening in entering, causes pump to re-compress.

Interior intake section length

Interior intake section length can be measured to downstream from upstream extremity, and wherein upstream extremity and downstream refer to operation dress Put period air or other propellant flow directions (i.e. air or other propellants can flow to the downstream) from upstream.Interior inlet portion Point length can be the length of powdered treatment preparation storage chamber (938).Interior intake section length can be the length of blast tube.In Intake section length can be the most about length of (downstream) bottom valve tip portion top (upstream extremity) to nozzle bore.When When powdered treatment preparation is present in powdered treatment preparation storage chamber (938), interior intake section length can be at least about from valve The top (upstream extremity) of tip portion is to the length higher than powdered treatment preparation height (upstream extremity) length.Interior intake section is long Degree can be at least about the top (upstream) from valve tip portion to the powdered treatment preparation storage chamber (938) can be made to exist Pump is activated or can not enter the length of length of pump during deexcitation.Interior intake section length can be at least about from valve top ends The top (upstream) divided is to being deactivated at device or can make the powdered treatment in storage chamber (938) when there is negative pressure in device Preparation can not enter or be inhaled into the length of the length of pump.

Interior intake section upstream to downstream length can be less than about 5cm, less than about 4.5cm, less than about 4cm, less than about 3.5cm, less than about 3cm, less than about 2.5cm, less than about 2cm, less than about 1.5cm, less than about 1.0cm or less than about 0.5cm. Interior intake section length can be about 0.5cm to 5cm, about 1cm to 5cm, about 1cm to 4cm, about 1cm to 3cm, about 2cm to 5cm, Or about 2cm to 4cm.Interior intake section length can be about 0.5cm, 1cm, 1.5cm, 2cm, 2.5cm, 3cm, 3.5cm, 4cm, 4.5cm or 5cm.Interior intake section length can be more than 0.5cm, 1cm, 1.5cm, 2cm, 2.5cm, 3cm, 3.5cm, 4cm, 4.5cm or 5cm.

The external width of interior intake section

In some embodiments, interior intake section be perpendicular to upstream to the external width of downstream shaft in its widest portion Be about 0.01cm to 0.2cm, 0.01cm to about 0.15cm, 0.01cm to about 0.1cm, 0.01cm to about 0.05cm, 0.02cm extremely 0.2cm, 0.02cm are to about 0.15cm, 0.02cm to about 0.1cm, 0.02cm to about 0.05cm, 0.03cm to 0.2cm, 0.03cm To about 0.15cm, 0.03cm to about 0.1cm, 0.03cm to about 0.05cm, 0.04cm to 0.2cm, 0.04cm to about 0.15cm, 0.04cm to about 0.1cm or 0.04cm to about 0.05cm.In some embodiments, interior intake section be perpendicular to upstream extremely The external width of downstream shaft its widest portion less than 0.01cm, 0.02cm, 0.03cm, 0.04cm, 0.05cm, 0.06cm, 0.07cm、0.08cm、0.09cm、0.1cm、0.11cm、0.12cm、0.13cm、0.14cm、0.15cm、0.16cm、0.17cm、 0.18cm, 0.19cm, 0.2cm, 0.3cm or 0.4cm width.In some embodiments, interior intake section be perpendicular to upstream extremely The external width of downstream shaft its widest portion be about 0.01cm, 0.02cm, 0.03cm, 0.04cm, 0.05cm, 0.06cm, 0.07cm、0.08cm、0.09cm、0.1cm、0.11cm、0.12cm、0.13cm、0.14cm、0.15cm、0.16cm、0.17cm、 0.18cm, 0.19cm, 0.2cm, 0.3cm or 0.4cm width.In some embodiments, interior intake section be perpendicular to upstream extremely The external width of downstream shaft its widest portion exceed about 0.01cm, 0.02cm, 0.03cm, 0.04cm, 0.05cm, 0.06cm, 0.07cm、 0.08cm、0.09cm、0.1cm、0.11cm、0.12cm、0.13cm、0.14cm、0.15cm、0.16cm、0.17cm、 0.18cm, 0.19cm, 0.2cm, 0.3cm or 0.4cm width.

In some embodiments, interior intake section be perpendicular to upstream to the external width of downstream shaft in its narrowest part No more than about 0.01cm, 0.02cm, 0.03cm, 0.04cm, 0.05cm, 0.06cm, 0.07cm, 0.08cm, 0.09cm, 0.1cm, 0.11cm, 0.12cm, 0.13cm, 0.14cm, 0.15cm, 0.16cm, 0.17cm, 0.18cm, 0.19cm, 0.2cm, 0.3cm or 0.4cm.In some embodiments, interior intake section be perpendicular to upstream to the external width of downstream shaft in its position, narrowest part In 0.01cm to 0.2cm, 0.01cm to about 0.15cm, 0.01cm to about 0.1cm, 0.01cm to about 0.05cm, 0.02cm extremely 0.2cm, 0.02cm are to about 0.15cm, 0.02cm to about 0.1cm, 0.02cm to about 0.05cm, 0.03cm to 0.2cm, 0.03cm To about 0.15cm, 0.03cm to about 0.1cm, 0.03cm to about 0.05cm, 0.04cm to 0.2cm, 0.04cm to about 0.15cm, In the range of 0.04cm to about 0.1cm or 0.04cm to about 0.05cm.In some embodiments, interior intake section is vertical In upstream to the external width of downstream shaft in its narrowest part be about 0.01cm, 0.02cm, 0.03cm, 0.04cm, 0.05cm, 0.06cm、0.07cm、0.08cm、0.09cm、0.1cm、0.11cm、0.12cm、0.13cm、0.14cm、0.15cm、0.16cm、 0.17cm, 0.18cm, 0.19cm, 0.2cm, 0.3cm or 0.4cm.In some embodiments, being perpendicular to of interior intake section Upstream to the external width of downstream shaft exceed in its narrowest part about 0.01cm, 0.02cm, 0.03cm, 0.04cm, 0.05cm, 0.06cm、0.07cm、0.08cm、0.09cm、0.1cm、0.11cm、0.12cm、0.13cm、0.14cm、0.15cm、0.16cm、 0.17cm, 0.18cm, 0.19cm, 0.2cm, 0.3cm or 0.4cm.

Interior intake section width can be changed stepwise with consecutive variations, not change, or a combination thereof.Interior intake section Insied width and outer width can be changed stepwise with consecutive variations, not change, or a combination thereof.Interior inlet upstream and downstream can With same widths or difference.In some embodiments, interior entrance is the widest and narrowest part is in end (that is: valve tip portion Top (upstream axle) and the upstream-end opening of valve pocket (946)).Such as, interior intake section widest portion can be upstream extremity with And interior intake section narrowest part can be in downstream, or vice versa as the same.In some embodiments, interior intake section is the widest And/or narrowest part is not in end.In some embodiments, interior intake section widest portion is for being connected to valve top Partly bottom the interior intake section of (918).

The inner width of intake section in outside

In some embodiments, interior intake section be perpendicular to upstream to the inner width of downstream shaft in its widest portion About 0.001cm to 0.2cm, 0.001cm to about 0.15cm, 0.001cm to about 0.1cm, 0.001cm to about 0.06cm, 0.001cm is to about 0.05cm, 0.005cm to 0.2cm, 0.005cm to about 0.15cm, 0.005cm to about 0.1cm, 0.005cm extremely About 0.06cm, 0.005cm to about 0.05cm, 0.01cm to 0.2cm, 0.01cm to about 0.15cm, 0.01cm to about 0.1cm, 0.01cm is to about 0.06cm, 0.01cm to about 0.05cm, 0.015cm to 0.2cm, 0.015cm to about 0.15cm, 0.015cm extremely About 0.1cm, 0.015cm to about 0.06cm, 0.015cm to about 0.05cm, 0.02cm to 0.2cm, 0.02cm to about 0.15cm, 0.02cm is to about 0.1cm, 0.02cm to about 0.06cm or 0.02cm to about 0.05cm.In some embodiments, interior inlet portion Point be perpendicular to upstream to downstream shaft inner width its widest portion be no more than about 0.001cm, 0.002cm, 0.003cm, 0.004cm、0.005cm、0.006cm、0.007cm、0.008cm、0.009cm、0.01cm、0.015cm、0.02cm、 0.025cm、0.03cm、0.035cm、0.04cm、0.045cm、0.05cm、0.055cm、0.06cm、0.065cm、0.07cm、 0.075cm、0.08cm、0.085cm、0.09cm、0.095cm、0.1cm、0.11cm、0.12cm、0.13cm、0.14cm、 0.15cm, 0.16cm, 0.17cm, 0.18cm, 0.19cm or 0.2cm width.In some embodiments, interior intake section is vertical Straight in upstream to downstream shaft inner width its widest portion exceed about 0.001cm, 0.002cm, 0.003cm, 0.004cm, 0.005cm、0.006cm、0.007cm、0.008cm、0.009cm、0.01cm、0.015cm、0.02cm、0.025cm、0.03cm、 0.035cm、0.04cm、0.045cm、0.05cm、0.055cm、0.06cm、0.065cm、0.07cm、0.075cm、0.08cm、 0.085cm、0.09cm、0.095cm、0.1cm、0.11cm、0.12cm、0.13cm、0.14cm、0.15cm、0.16cm、 0.17cm, 0.18cm, 0.19cm or 0.2cm width.In some embodiments, interior intake section be perpendicular to upstream to downstream The inner width of axle its widest portion be about 0.001cm, 0.002cm, 0.003cm, 0.004cm, 0.005cm, 0.006cm, 0.007cm、0.008cm、0.009cm、0.01cm、0.015cm、0.02cm、0.025cm、0.03cm、0.035cm、0.04cm、 0.045cm、0.05cm、0.055cm、0.06cm、0.065cm、0.07cm、0.075cm、0.08cm、0.085cm、0.09cm、 0.095cm、0.1cm、0.11cm、0.12cm、0.13cm、0.14cm、0.15cm、0.16cm、0.17cm、0.18cm、0.19cm、 Or 0.2cm width.

In some embodiments, interior intake section be perpendicular to upstream to the inner width of downstream shaft in its narrowest part No more than about 0.001cm, 0.002cm, 0.003cm, 0.004cm, 0.005cm, 0.006cm, 0.007cm, 0.008cm, 0.009cm、0.01cm、0.015cm、0.02cm、0.025cm、0.03cm、0.035cm、0.04cm、0.045cm、0.05cm、 0.055cm、0.06cm、0.065cm、0.07cm、0.075cm、0.08cm、0.085cm、0.09cm、0.095cm、0.1cm、 0.11cm, 0.12cm, 0.13cm, 0.14cm, 0.15cm, 0.16cm, 0.17cm, 0.18cm, 0.19cm or 0.2cm width.At certain In a little embodiments, upstream to the inner width of downstream shaft that is perpendicular to of interior intake section exceedes about in its narrowest part 0.001cm、0.002cm、0.003cm、0.004cm、0.005cm、0.006cm、0.007cm、0.008cm、0.009cm、 0.01cm、0.015cm、0.02cm、0.025cm、0.03cm、0.035cm、0.04cm、0.045cm、0.05cm、0.055cm、 0.06cm、0.065cm、0.07cm、0.075cm、0.08cm、0.085cm、0.09cm、0.095cm、0.1cm、0.11cm、 0.12cm, 0.13cm, 0.14cm, 0.15cm, 0.16cm, 0.17cm, 0.18cm, 0.19cm or 0.2cm width.Implement at some In mode, upstream to the inner width of downstream shaft that is perpendicular to of interior intake section is positioned at 0.001cm extremely in its narrowest part 0.2cm, 0.001cm to about 0.15cm, 0.001cm to about 0.1cm, 0.001cm to about 0.06cm, 0.001cm to about 0.05cm, 0.005cm to 0.2cm, 0.005cm are to about 0.15cm, 0.005cm to about 0.1cm, 0.005cm to about 0.06cm, 0.005cm extremely About 0.05cm, 0.01cm to 0.2cm, 0.01cm to about 0.15cm, 0.01cm to about 0.1cm, 0.01cm to about 0.06cm, 0.01cm is to about 0.05cm, 0.015cm to 0.2cm, 0.015cm to about 0.15cm, 0.015cm to about 0.1cm, 0.015cm extremely About 0.06cm, 0.015cm to about 0.05cm, 0.02cm to 0.2cm, 0.02cm to about 0.15cm, 0.02cm to about 0.1cm, In the range of 0.02cm to about 0.06cm or 0.02cm to about 0.05cm.In some embodiments, interior intake section is vertical In upstream to the inner width of downstream shaft in its narrowest part be about 0.001cm, 0.002cm, 0.003cm, 0.004cm, 0.005cm、0.006cm、0.007cm、0.008cm、0.009cm、0.01cm、0.015cm、0.02cm、0.025cm、0.03cm、 0.035cm、0.04cm、0.045cm、0.05cm、0.055cm、0.06cm、0.065cm、0.07cm、0.075cm、0.08cm、 0.085cm、0.09cm、0.095cm、0.1cm、0.11cm、0.12cm、0.13cm、0.14cm、0.15cm、0.16cm、 0.17cm, 0.18cm, 0.19cm or 0.2cm width.

The internal capacity of interior intake section

Interior intake section can be hollow and can comprise internal capacity.The internal capacity of interior intake section can be about 0.0001cm³Or more, 0.0005cm³Or more, 0.001cm³Or more, 0.005cm³Or more, 0.01cm³Or more, 0.02cm³Or more or 0.03cm³Or it is more.In some embodiments, the internal capacity of interior intake section is about 0.0001cm³To about 0.03cm³, about 0.0001cm³To about 0.02cm³, about 0.0001cm³To about 0.01cm³, about 0.0001cm³ To about 0.005cm³, about 0.0001cm³To about 0.001cm³, about 0.0001cm³To about 0.0005cm³, about 0.0005cm³To about 0.03cm³, about 0.0005cm³To about 0.02cm³, about 0.0005cm³To about 0.01cm³, about 0.0005cm³To about 0.005cm³、 About 0.0005cm³To about 0.001cm³, about 0.001cm³To about 0.03cm³, about 0.001cm³To about 0.02cm³, about 0.001cm³ To about 0.01cm³, about 0.001cm³To about 0.005cm³, about 0.005cm³To about 0.03cm³, about 0.005cm³To about 0.02cm³、 About 0.005cm³To about 0.01cm³, about 0.01cm³To about 0.03cm³, or about 0.01cm³To about 0.02cm³.In interior intake section Portion's volume can be about 0.0001cm³、0.0002cm³、0.0003cm³、0.0004cm³、0.0005cm³、0.0006cm³、 0.0007cm³、0.0008cm³、0.0009cm³、0.001cm³、0.002cm³、0.003cm³、0.004cm³、0.005cm³、 0.006cm³、0.007cm³、0.008cm³、0.009cm³、0.011cm³、0.012cm³、0.013cm³、0.014cm³、 0.015cm³、0.016cm³、0.017cm³、0.018cm³、0.019cm³、0.02cm³、0.021cm³、0.022cm³、0.023cm<3 >、0.024cm³、0.025cm³、0.026cm³、0.027cm³、0.028cm³、0.029cm³、0.03cm³、0.04cm³、0.05cm³、 0.06cm³、0.07cm³、0.08cm³、0.09cm³, or 1.0cm³.Interior intake section internal capacity can be more than 0.0001cm³、 0.0005cm³、0.001cm³、0.005cm³、0.01cm³、0.02cm³, or 0.03cm³.Interior intake section internal capacity can be Less than 0.0001cm³、0.0005cm³、0.001cm³、0.005cm³、0.01cm³、0.02cm³, or 0.03cm³。

Throat encloses

Air source flow export may be located at the throat of air source (such as manual air pump and/or bottle).Manual air pump Or bottle can comprise throat's circle of bottle manual air pump throat.Throat's circle can be fused to manual air pump or bottle larynx Portion.Throat's circle is inserted into manual air pump or bottle throat.Throat's circle can be set to limit manual air pump or little The width of bottle throat.Opening on throat's circle can be the width more narrower than check valve widest portion width.

1 to 20mm, 1 to 10mm, 1 to 7.5mm or 1 to 5mm is can be about by the width in the hole of throat's circle formation.Logical The width crossing the hole that throat's circle is formed can be about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 Or 20mm.The width in hole formed by throat's circle can exceed about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15, 16,17,18,19 or 20mm.By throat circle formed hole width can less than about 1,2,3,4,5,6,7,8,9,10,11, 12,13,14,15,16,17,18,19 or 20mm.

Throat's loop diameter can be about 1 to 20mm, 1 to 17.5mm, 1 to 15mm, 1 to 12.5mm, 1 to 10mm, 1 to 7.5mm or 1 to 5mm.Throat's loop diameter can be about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17, 18,19 or 20mm.Throat's loop diameter can more than about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17, 18,19 or 20mm.Throat's loop diameter can less than about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17, 18,19 or 20mm.

Throat circle highly can be about 1 to 20mm, 1 to 17.5mm, 1 to 15mm, 1 to 12.5mm, 1 to 10mm, 1 to 7.5mm or 1 to 5mm.Throat's circle highly can be about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17, 18,19 or 20mm.Throat's circle highly can more than about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17, 18,19 or 20mm.Throat circle highly can less than about 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17, 18,19 or 20mm width.Throat's circle highly can be identical or different with manual air pump or bottle throat height.

Throat's circle thickness (throat's circle inner edge is to the distance of outer rim) can be about 0.1 to 20mm, 0.1 to 15mm, 0.1 to 10mm, 0.1 to 7.5mm, 0.1 to 5mm or 0.1 to 2.5mm.Throat's circle thickness (distance of throat's circle inner edge to outer rim) is permissible About 0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8, 1.9、2、2.1、2.2、2.3、2.4、2.5、2.6、2.7、2.8、2.9、3、3.1、3.2、3.3、3.4、3.5、3.6、3.7、3.8、 3.9、4、4.1、4.2、4.3、4.4、4.5、4.6、4.7、4.8、4.9、5、5.1、5.2、5.3、5.4、5.55.6、5.7、5.8、 5.9、6、6.1、6.2、6.3、6.4、6.5、6.6、6.7、6.8、6.9、7.0、7.1、7.2、7.3、7.4、7.5、7.6、 7.7、 7.8、7.9、8.0、8.1、8.2、8.3、8.4、8.5、8.6、8.7、8.8、8.9、9、9.1、9.2、9.3、9.4、9.5、9.6、 9.7,9.8,9.9 or 10mm.Throat's circle thickness (throat's circle inner edge is to the distance of outer rim) can more than about 0.1,0.2,0.3, 0.4、0.5、0.6、0.7、0.8、0.9、1、1.1、1.2、1.3、1.4、1.5、1.6、1.7、1.8、1.9、2、2.1、2.2、2.3、 2.4、2.5、2.6、2.7、2.8、2.9、3、3.1、3.2、3.3、3.4、3.5、3.6、3.7、3.8、3.9、4、4.1、4.2、4.3、 4.4、4.5、4.6、4.7、4.8、4.9、5、5.1、5.2、5.3、5.4、5.55.6、5.7、5.8、5.9、6、6.1、6.2、6.3、 6.4、6.5、6.6、6.7、6.8、6.9、7.0、7.1、7.2、7.3、7.4、7.5、7.6、7.7、7.8、7.9、8.0、8.1、8.2、 8.3,8.4,8.5,8.6,8.7,8.8,8.9,9,9.1,9.2,9.3,9.4,9.5,9.6,9.7,9.8,9.9 or 10mm.Throat Circle thickness (throat's circle inner edge is to the distance of outer rim) can less than about 0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9, 1、1.1、1.2、1.3、1.4、1.5、1.6、1.7、1.8、1.9、2、2.1、2.2、2.3、2.4、2.5、2.6、2.7、2.8、2.9、 3、3.1、3.2、3.3、3.4、3.5、3.6、3.7、3.8、3.9、4、4.1、4.2、4.3、4.4、4.5、4.6、4.7、4.8、4.9、 5、5.1、5.2、5.3、5.4、5.5、5.6、5.7、5.8、5.9、6、6.1、6.2、6.3、6.4、6.5、6.6、6.7、6.8、6.9、 7.0、7.1、7.2、7.3、7.4、7.5、7.6、7.7、7.8、7.9、8.0、8.1、8.2、8.3、8.4、8.5、8.6、8.7、8.8、 8.9,9,9.1,9.2,9.3,9.4,9.5,9.6,9.7,9.8,9.9 or 10mm.

Throat circle can by multiple polymers, plastics, rubber, silicones, metal, composite, described herein as be suitable for For other material any manufacturing intranasal delivery device or any other material being suitable in nasal delivery device. Throat's circle can be made up of a kind of material or a class material.Selectively, throat's circle can be by two or more different materials Or different materials kind composition.Part or all of throat's circle can be biocompatible materials or by low irritability material. Throat's circle can by rigidity, substantially rigidity, flexible or the most flexible material, or combinations thereof.? In some embodiments, throat circle can by one or more paper, silicones, acrylate, polyethylene, polyurethane, polyurethane, Hydrogel, polyester (such as, from E.I.Du Pont de Nemours and Company, Wilmington, Del.'s DACRONB), polypropylene, politef (PTFE), varicosity PTFE (ePTFE), polyether-ether-ketone (PEEK), nylon, the glue of extrusion Former albumen, polymer foams, rubber, silicone rubber, polyethylene terephthalate, ultra-high molecular weight polyethylene, poly-carbon Acid esters carbamate, polyurethane, polyimides, aluminum, rustless steel, Nitinol (such as, Nitinol), titanium, rustless steel, cobalt Evanohm is (such as, from Elgin Specialty Metals, the ELGILOYB of Elgin, Ill.；From Carpenter Metals Corp., the CONICHROMEB of Wyomissing, Pa.) composition.

Device described herein may be used for delivering can any compositions of nasal delivery there.Such as, device can be used for Curative, trophism or other expectation compositionss dried powder preparation.

Method

Provided in this article is the method with intranasal delivery device described herein delivery powdered treatment preparation to experimenter. Medicine can be loaded to nozzle, and the nozzle with medicine can be connected to air source.If intranasal delivery device comprises Lid, such as, can be removed and maybe can crush lid, or cap, and lid can be removed from intranasal delivery device.Removing can be by broken Broken, mention, twist, compress or cap.When device is not activated, check valve can be still in bottle throat surface to be prevented Only powdered treatment preparation is traveling upstream into air source (such as, flexible bladder).Nozzle can be inserted into or partial insertion To experimenter nostril.User may be inserted into device or other people (such as, health care provider) may be inserted into device to being subject to Examination person nostril.Device can be activated (such as, by compressing the air source as flexible bladder, by activating forced air Source).Air flows out air source flow export and causes check valve to rise in device nozzle.When check valve rises in nozzle, It is no longer still in bottle throat.Check valve non-slit part can be with contact nozzle pipe to prevent powdered treatment preparation upstream It is moved into air source.Air can advance and flow through the slit of check valve along partially unidirectional valve.Then air can flow into storage Room and force powdered treatment preparation to rise to blast tube mass flowing nozzle hole.And enter experimenter nostril.Fig. 3 illustrate by The intranasal delivery device activated.

Storage indoor air flow

As shown in the partial view in device embodiments in Fig. 6, powdered treatment preparation can be found in nozzle Wall (Y) and being positioned between check valve (116) and nozzle inner walls (Z).When air source is activated, check valve can be adapted for Storage chamber allows flow rotation.Such as, in check valve, one or more slits (128) tiltable is orientated thus when air source is swashed Produce eddy airstream when living, and eddy airstream can take away powder from nozzle inner walls.

Fig. 7 A and 7B illustrate when the upper slit of first shelf (730) of check valve (700) be non-inclined (Fig. 7 A, 740) with And when slit be tilt (Fig. 7 B, 750) time along nozzle inner walls and along check valve (700) surface air enter difference Different.Shown in Fig. 7 A and 7B is tip portion (710), the first cylindrical portion (720), and the part of check valve (700) One shelf (730).When the one or more slits on the first shelf (730) be non-inclined (Fig. 7 A, 740) time, in air source When being activated, there is the region in the nozzle inner walls that air stream can not arrive.When air source is activated, there is air stream can not The region along the first cylindrical portion (720) (762) arrived.Also show when air source is activated, represent air stream The nozzle inner walls region that can arrive.

When slits one or more on the first shelf are tilted alignments (Fig. 7 B, 750), air stream can contact check valve Whole inwalls (768) of the nozzle in the first cylindrical portion (720) downstream.Air stream can not arrive along the first cylindrical portion Divide the region (766) of (726) if being minimum relative to one or more slits situation of non-inclined orientation on the first shelf (such as, in comparison diagram 7B in 766 regions and Fig. 7 A 762 regions) changed.Non-incline relative to having on check valve the first shelf The tiltedly device of slit, when a device is activated, on check valve the first shelf, the device of angled slots can have and is positioned at nozzle The delivery of the powdered treatment preparation between wall and check valve increases.

Fig. 8 A and 8B illustrates when the slit on the first shelf (830) is non-tilted alignment (Fig. 8 A, 840) and works as slit When being tilted alignment (Fig. 8 B, 850), the difference that air stream enters along check valve (800).When one or more on the first shelf When slit is tilted alignment (Fig. 8 B, 850), if relative to one or more slits at the first shelf being the feelings of non-tilted alignment The region along the first cylindrical portion (820) that under condition, air stream can not arrive minimizes (such as, 860th district of comparison diagram 8A Territory and 862 regions of 7B).Relative to having the device of non-inclined slit on check valve the first shelf, check valve the first shelf On there is the powder that the device of angled slots can have between nozzle inner walls and check valve when device is activated control The increase treating preparation delivers.

Assemble

Powdered treatment preparation can be loaded in nozzle.Nozzle can have cap, removable or removable lid Deng.Then nozzle can be coupled to air source.Nozzle can be screwed to nozzle in air source by such as, and clamping nozzle is to empty On source of the gas, fasten nozzle and be coupled in air source to air source.

II. compositions

Device described herein is suitable for delivering treatment preparation, includes but not limited to free alkali and the salt form of therapeutic agent.Control Treating agent can be crystal or amorphous form.Powdered treatment preparation can be made up of or it the only therapeutic agent of " without carrier " Can comprise further suitable carrier, filler, diluent, excipient, penetration enhancers, lytic agent and auxiliary agent or other Material.

Device described herein can protect powdered treatment preparation to exempt from dampness or air before device prepares to use.Logical Cross and remove or break protective cover, can be to be used with preparation device.Anhydrous composition can be provided that in storage chamber and device Can be known to prevent the material being exposed to dampness or water from packing by use further thus they can be contained in properly Formula medicine box.The example of suitable package, includes but not limited to the paper tinsel of hermetic seal, plastics etc., unit dosage container, blister pack It is filled with and divests packaging.

Medicine box

Provide the medicine box using therapeutic combination described herein.In some embodiments, medicine box comprises and is applicable to nose The dried powder inside used is treated preparation unit dosage and provides intranasal delivery device or allotter.At some embodiment In, therapeutic combination exists with therapeutic dose.In some embodiments, medicine box comprises carrier, packs or is divided into acceptance one Individual or the container of multiple blister package, bottle, pipe, capsule etc..In some embodiments, pharmaceutical composition is with containing comprising herein Presented in the packaging of one or more unit dosage forms of provided compound or allotter.At some embodiments In, comprise metal or plastic foil, such as blister package.In some embodiments, capsule, box, bottle or pipe are comprised. In other embodiment, packaging or distributor are with the description for using.In some embodiments, distribution Device is discardable or disposable, but in other embodiments, allotter is reusable.Real at some Executing in mode, pharmaceutical preparation is preloaded into device.In some embodiments, intranasal applicator have no more than about 3mL, The volume of 5mL, 10mL, 15mL, 20mL, 30mL, 40mL or 50mL.

In some embodiments, the government organs that packaging or disperser also use with management drug manufacture or sell Required notice.Notice set forth medicine by people with or management board for animals ratify.This notice, such as, is U.S.'s food The approval of product Drug Administration is for the mark prescribed for medicine or approval product.It is configured in compatible pharmaceutical carrier In the compositions containing compound described herein be also produced, be placed in suitable carrier, and indicate for treating prompting The mark of indication.

The product of preparation presented herein also comprises intranasal administration or dispersal device.Device may rely on patient and sucks Transport preparation, or pump can be provided that in or is implemented in device and helps aerosolization or transport preparation.Selectively, propellant Can be included in or it can be stored in device.

Medicine box selectively comprises the description for container or identification explanation.In further embodiment, mark It is to there is on container formation mark and be connected, cast or be etched in the letter of container self, numeral or other features.When It is present in when also holding in the storage of container or carrier, and mark is associated with container, such as, as package insert. In some embodiments, mark is used for pointing out its content to be used for a specific treatment use.Also in some other enforcement In mode, identify the instruction of also suggestion content thing purposes, such as in methods described herein.A set of instruction also can be generally with medicine The form of description is comprised.Information material can include how to disperse the instruction of therapeutic combination, including the disease that can be treated People's kind, application program (such as, dosage and frequency) etc..

Embodiment

Embodiment 1. delivers therapeutic agent and is used alone device to experimenter

Device is placed by user, so that the nozzle of device is at least partially disposed in experimenter nostril.User is with big The power of about 25kPa compressed air source between thumb and forefinger.Powder present in the storage chamber being configured in device nozzle Treatment preparation is delivered to the nostril of experimenter.User visual inspection nozzle also assert that the therapeutic agent of q.s is from nozzle Leave away and be delivered.

Embodiment 2. uses device to deliver single use therapeutic agent to experimenter

Device is placed by user, so that device nozzle is at least partially disposed in experimenter nostril.User compressed-bit Air source between thumb and forefinger.Check valve primary importance from device moves to the second position, and air movement is more Cross slit surface in check valve and enter the storage chamber comprising treatment preparation.Powder present in the storage chamber being configured in device nozzle Shape therapeutic agent is delivered entrance experimenter nostril.User visual inspection nozzle also assert that q.s therapeutic agent does not leaves nozzle And be delivered.User repeated compression air source is until the therapeutic agent of visual inspection display q.s has been moved off nozzle and passed Send.

Embodiment 3. intranasal delivery device

Fig. 1 illustrates the sectional view of disposable intranasal delivery device.Intranasal delivery device (100) can comprise sky Source of the gas, it can be flexible bladder (102).Flexible bladder can have the function of manual air pump (104).Flexible bladder can wrap Containing inflow entrance (not shown) and flow export (106).Flexible bladder may be embodied in the throat (108) at flexible bladder top, its tool There is the diameter more narrower than (110) bottom flexible bladder.Throat (108) could be included for being connected to the external screw thread of nozzle (114) (112)。

When device is not activated (such as, when manual air pump is uncompressed), check valve (116) may be located at flexible bladder (102) on throat (108) surface and block flow export (106).When device is not activated, check valve (116) is still in larynx Powdered treatment preparation (M) it is possible to prevent to enter flexible bladder (102) on portion (108) surface.

Check valve (116) can comprise tip portion (118), the first cylindrical portion (120), the first shelf (122), Two cylindrical portion (124) and the second shelf (126).One or more slits (128) can be on the first shelf surfaces.Work as hands When dynamic air pump (104) is compressed (see, e.g. Fig. 3), one or more slits (128) can allow air or gas from soft Property bottle (102) flows to nozzle (114).Check valve (116) embodiment is shown in Fig. 2.

Intranasal device (100) can comprise nozzle (114) further, and it contains and can be inserted into or be inserted partially into experimenter The blast tube (130) in nasal cavity or nostril.Nozzle (114) can comprise nozzle bore (132) further, removable maybe can crush lid And powdered treatment preparation storage chamber (138) (134).Powdered treatment preparation storage chamber can comprise powdered treatment preparation (M). Nozzle (114) can comprise bottom (140), and it contains the female thread for being connected to flexible bladder (102) throat (108) (142)。

Embodiment 4. check valve

Fig. 2 illustrates the view of the different embodiments of the check valve (116) corresponding to check valve shown in Fig. 1 (116). Fig. 2 i illustrates the side view of the check valve (116) with sensing left, check valve top.In this embodiment, check valve bag Containing tip portion (118) and the first cylindrical portion (120) from the extension of tip portion (118) bottom.At the first cylindrical portion Bottom point is the first shelf (122) outwards downwardly extending extension from the first cylindrical portion (120).Shown therein is The single slit at the first shelf (122) top, this slit becomes non-90-degree angle relative to any side of shelf.First shelf can have Multiple slits.The top of the second cylindrical portion (124) it is connected to bottom first shelf.The bottom of the second cylindrical portion connects To the second shelf (126) extended inwardly downward relative to the second cylindrical portion (124) bottom.

It is unidirectional that Fig. 2 ii illustrates along Fig. 2 i midplane AA observed from the right side of check valve (116) shown in Fig. 2 i Valve sectional view.Described cross sectional view show is corresponding to multiple recesses along check valve the first shelf circumference of slit (128) (128).It can be hollow that middle circle (136) illustrates check valve (116).

Fig. 2 iv-2vi illustrates the check valve along Fig. 2 i midplane AA observed from the right side of check valve shown in Fig. 2 i The sectional view of a part.Illustrate the different geometries of the slit that can be formed at Fig. 2 i check valve top shelf.At this view In slit geometry can pass through curved surface (Fig. 2 iv), two surfaces (Fig. 2 v), or three surfaces (Fig. 2 vi) are formed.

Embodiment 5: the intranasal delivery device of activation

Fig. 3 illustrates the activation form of intranasal delivery device shown in Fig. 1, and air or gas are from manual air pump (104) to the current path of nozzle (114).Remove can be removed from intranasal delivery device (100) and maybe can crush lid (134). User's compression as the flexible bladder (102) of manual air pump (104) (by arrow and soft relative to deform at Fig. 1 bottle Property bottle illustrates compression).Air flows out the flow export (106) of flexible bladder (102).Air-flow causes check valve (116) in spray Rise in mouth (114).Check valve the first shelf (122) non-slit part contacts with blast tube (130), thus stops powder to be controlled Treat preparation and be upstream manoeuvred into flexible bladder (102).Air is along second shelf (126) of check valve (116) and single Advance to second cylindrical portion (124) of valve (116), and narrow by first shelf (122) of check valve (116) Seam (128) flowing.Then, air flows into storage chamber (138) between the first cylindrical portion (120) and blast tube (130) And force powdered treatment preparation (M) rise through blast tube (130) and leave nozzle bore (132).

Embodiment 6. delivery apparatus: single use device

Intranasal preparation is delivered to nasal cavity by intranasal delivery device described herein.Intranasal delivery device described herein is empty Air driving device, it is designed to intranasal delivery TRG.As it is shown in figure 1, powder formulation is preloaded with in device.In use, Plastic pulling ring or airtight cap are removed, as it is shown on figure 3, thus remove the obstacle on powder formulation path, it is allowed to intranasal preparation quilt Release.Once removing plastic pulling ring or airtight cap from applicator described herein, patient i.e. can press-fit by manual pump easily Put, and be delivered to nasal cavity by the single nozzle of device.Intranasal preparation uses intranasal delivery device described herein to be applied to nose Chamber.Analyze the intranasal preparation powder secondary particles size and dimension from applicator release herein to assess and intranasal described herein Delivery apparatus combines the delivery properties of intranasal preparation powder produced.

While characterized as with illustrate preferred embodiment, clearly these embodiment party for by skilled person Formula is only used as example and provides.Those skilled in the art can find multiple change, change and substitute without departing from described herein Device, method and composition.It is to be understood that the various changes of embodiment described herein can be used for implementing device described herein, method And compositions.Following claims is intended to the scope of definition method, compositions and device and therefore covers these claim In the range of method, compositions device and their equivalent.

Claims

1. device, comprises:

The nozzle that is adapted to allow for a) with upstream extremity and downstream is placed on the intranarial nozzle of experimenter at least partially；

B) comprising the storage chamber of single dose powdered treatment preparation, storage chamber has upstream extremity and downstream, and is arranged at nozzle In；

C) have a valve of upstream extremity and downstream, wherein 1) valve is suitable in occupying device primary importance and the second position, 2) Valve is suitable for causing powdered treatment preparation to spread when a device is activated, and 3) valve comprises and is connected to the first cylindrical portion Tapered tip part, wherein the first cylindrical portion is connected to the first shelf, and the first shelf is connected to the second cylinder Shape part；With

D) being operably connected to the air source of the upstream extremity of described valve, wherein device is single use device, and

Wherein the first shelf comprises at least one slit.

2. the device in claim 1, wherein valve is suitable for when air source is activated producing eddy airstream in storage chamber.

3. the device in claim 1, wherein valve is suitable for when air source is activated, it is allowed to the whole wall of storage chamber is covered by air-flow Lid.

4. the device in claim 1, in wherein valve is at least partially disposed at nozzle.

5. the device in claim 4, wherein powdered treatment preparation is located along nozzle inner walls and between valve and nozzle inner walls.

6. the device in claim 5, wherein valve is suitable for when air source is activated, reduce reside in valve and nozzle inner walls it Between powdered treatment preparation.

7. the device in claim 1, wherein device is suitable for delivering the described powder of the single dose of 80% to 99% and controls Treat preparation to experimenter nostril.

8. the device in claim 1, wherein device is suitable for after single actuation air source, delivers the single of 80% to 99% The described powdered treatment preparation of dosage is to experimenter nostril.

9. the device in claim 1, wherein air source includes flow export.

10. the device in claim 9, wherein valve is suitable for when device is not activated, and prevents powdered treatment preparation from moving Pass through flow export.

Device in 11. claim 9, wherein valve is suitable for when a device is activated, it is allowed to powdered treatment preparation moves logical Cross flow export.

Device in 12. claim 9, wherein when device is not activated, valve covers flow export.

Device in 13. claim 9, valve does not cover flow export the most when a device is activated.

Device in 14. claim 1, wherein the surface of the first shelf comprises at least one slit.

Device in 15. claim 1, wherein the first shelf comprises 1 to 50 slit.

Device in 16. claim 1, wherein the first shelf comprises 1 to 20 slit.

Device in 17. claim 1, wherein the first shelf comprises 1 to 10 slit.

Device in 18. claim 1, at least one of which slit becomes 45 degree of angles relative to the edge of the first shelf.

Device in 19. claim 14, at least one of which slit is suitable for when air source is used, it is allowed to from air source Air to nozzle flows.

Device in 20. claim 1, wherein nozzle comprises blast tube.

Device in 21. claim 20, wherein valve portion is positioned at blast tube.

Device in 22. claim 21, wherein the first cylindrical portion and the tapered tip part of valve is positioned at blast tube.

Device in 23. claim 21, wherein the second cylindrical portion of valve is not located in blast tube.

Device in 24. claim 20, wherein when air source is activated, the first shelf contact nozzle pipe.

Device in 25. claim 1, wherein air source is suitable for delivering the air of 2 to 7mL.

Device in 26. claim 1, wherein device is suitable for delivering the described powdered treatment preparation of 1 to 50mg.

Device in 27. claim 1, wherein device volume is less than 50cm³。

Device in 28. claim 1, wherein the quality of device is less than 20 grams.

Device in 29. claim 14, wherein air source comprises flow export, and wherein air source is suitable for being activated by a user Thus force air from described air source by described flow export, in the first shelf, the surface of at least one slit enters storage Room, and leave the downstream of nozzle.

Device in 30. claim 1, wherein device be suitable for when device uses storage chamber at least partially in provide laminar flow Air-flow.

Device in 31. claim 1, wherein air source comprises pump.

Device in 32. claim 31, wherein device is adapted to pass through the compression stress of application 5 to 30kPa to pump, and delivers powder Powder treatment preparation enters experimenter nostril.

Device in 33. claim 31, wherein pump comprises the deformable volume being suitable for being activated by a user further.

Device in 34. claim 31, wherein pump comprises manual air pump.

Device in 35. claim 34, wherein manual air pump is adapted to pass through user at thumb and forefinger, middle finger, unknown Refer to, between little finger or a combination thereof extrusion pump and be activated.

Device in 36. claim 1, wherein storage chamber comprises the internal diameter less than 10mm.

Device in 37. claim 1, wherein nozzle comprises further and is perpendicular to upstream to the length of the 5mm to 20mm of downstream shaft Degree.

Device in 38. claim 1, wherein nozzle comprises further and is parallel to upstream to the length of the 5mm to 40mm of downstream shaft Degree.

Device in 39. claim 1, wherein air source comprises inflow entrance and flow export, and the width of wherein said inflow entrance Degree or diameter are less than described flow export width or the 10% of diameter.

Device in 40. claim 39, wherein inflow entrance diameter is 0.1mm to 2mm.

Device in 41. claim 1, wherein nozzle comprise further be positioned at nozzle upstream end be suitable for prevent extraneous air The airtight cap of contact powdered treatment preparation.

Device in 42. claim 1, wherein nozzle comprises that be positioned at nozzle downstream further and is suitable for preventing air-flow By the removable cover of nozzle.

Device in 43. claim 1, wherein nozzle downstream comprises nozzle bore further.

Device in 44. claim 1, wherein valve is suitable for providing laminar air flow at least partially along storage chamber.

Device in 45. claim 1, wherein said valve is suitable for moving to the second position from primary importance, wherein first Position, the upstream face of described valve connects the air-flow hence into storage chamber with the flow export of described air source and is blocked, and The second position, the air stream entering storage chamber is allowed to.

Device in 46. claim 1, wherein at least 20kPa compression stress by being applied to air source produces sufficient air Stream.

Device in 47. claim 1, wherein nozzle is made up of substantial transparent or trnaslucent materials.

Device in 48. claim 1, wherein nozzle comprises the screw thread being suitable for fastening nozzle to air source further.

Device in 49. claim 1, wherein the first shelf comprises 3 to 20 slits.

Device in 50. claim 1, wherein the first shelf comprises 8 slits.

51. preparations are for delivering powdered treatment preparation to the method for the device of experimenter, and wherein method comprises the described powder of offer Powder treatment preparation is to storage chamber, and subsequently nozzle is connected to air source, and wherein device comprises:

A) having the nozzle of upstream extremity and downstream, nozzle is adapted to allow for nozzle is put into described experimenter at least partially Nostril；

B) comprising the storage chamber of potion powdered treatment preparation, storage chamber has upstream extremity and downstream, is operably connected and places In nozzle；

D) the described air source of described valve upstream extremity it is operably connected to,

Wherein the first shelf comprises at least one slit.

Device in 52. claim 42, wherein when the removable cover being positioned at nozzle downstream is not removed, device does not wraps Containing inflow entrance.

Device in 53. claim 52, wherein when removable cover is not removed, powdered treatment preparation storage chamber is to close System, thus, the powdered treatment in it has the air source storage chamber containing inflow entrance with comparable distributor Preparation stability is compared, and in storage chamber, the stability of powdered treatment preparation increases.

Device in 54. claim 42, wherein when the removable cover being positioned nozzle downstream is removed, device comprises Inflow entrance.

Device in 55. claim 1, wherein nozzle downstream comprises nozzle bore further, and wherein nozzle bore comprises stream Entrance.

Device in 56. claim 1, wherein valve comprises interior intake section, and it is cylindric that interior intake section is connected to described first Part.

Device in 57. claim 1, wherein valve also comprises interior intake section, and interior intake section is connected to tapered tip portion Point.

Device in 58. claim 1,56 or 57, wherein valve comprises valve pocket.

Device in 59. claim 58, wherein valve pocket comprises the hollow chamber being positioned at valve, is positioned at opening of valve pocket upstream extremity Mouthful, and it is positioned at the opening of valve pocket downstream.

The device of 60. claim 58, wherein valve pocket crosses over the whole length of valve.

The device of 61. claim 58, wherein valve pocket and the opening being positioned at valve pocket downstream are connected to storage chamber, and are positioned at valve pocket The opening of upstream extremity is connected to air source.

The device of 62. claim 52, in air source, whole air enter storage chamber the most when a device is activated, thus, with logical Cross activate comparable distributor its time there is the air source containing inflow entrance the delivery of powdered treatment preparation compare, The delivery of powdered treatment preparation increases.