CN103610801A - Traditional Chinese medicine composition for treating typhia and heat syncope - Google Patents
Traditional Chinese medicine composition for treating typhia and heat syncope Download PDFInfo
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- CN103610801A CN103610801A CN201310582551.9A CN201310582551A CN103610801A CN 103610801 A CN103610801 A CN 103610801A CN 201310582551 A CN201310582551 A CN 201310582551A CN 103610801 A CN103610801 A CN 103610801A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention provides a traditional Chinese medicine composition for treating typhoid and heat syncope, relating to the technical field of Chinese medicinal herbs. The composition is composed of the following active pharmaceutical ingredients: 10-20g of radix bupleuri, 10-20g of radix paeoniae alba, 5-15g of immature bitter orange, 8-14g of Baikal skullcap root, 5-15g of fiveleaf akebia, 1-10g of safflower and 5-15g of licorice. The composition has the characteristics of accessible materials, simple manufacturing process, low cost, reasonable formula, small dosage, low content of harmful ingredients, no toxic or side effect, obvious curative effect and the like.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine composition that is used for the treatment of typhoid fever cold limbs due to intense heat in the interior disease.
Background technology
Eight comas cards in < < Treatise on Febrile Diseases > >, comprise that cold limbs, cold limbs due to intense heat in the interior, water are fainted, syncope due to accumulation of phlegm, lose consciousness, syncope due to excessive bleeding, the ascariasis of biliary tract, visceral shock due to extreme YIN-cold etc.The card of fainting is outer time, and its pathogenesis is that Yinyang is mutually along connecing.
Cold limbs due to intense heat in the interior is that yang-energy is solely high, and pathogenic heat is deep, and causes yang-energy pent-up, can not be sensible due to the extremity.< < Treatise on Febrile Diseases > > says: " typhoid fever rolling pulse with coldness on the extremities person, heat in the interior, Baihu Tang master it." this is volt in pathogenic heat, the heat also dark meaning of deeply fainting.< < Yizong Jinjian > > thinks: " rolling pulse with coldness on the extremities, sliding is YANG pulse, interior-heat is known, be cold limbs due to intense heat in the interior also." You Zaijing proposition, faint pulse with coldness on the extremites is YIN pathogen damaging the spleen and stomach, trembles with fear inner; Rolling pulse with coldness on the extremities, YANG pathogen is hindered, heat in the interior.From clinical practice, though cold limbs due to intense heat in the interior extremity are cold, and the hands that burns that breast abdomen is laid one's hand on, or see to wave one's hand and throw foot, aversion to cold is thirsty, and agitation is not peaceful, even unconsciousness and delirium; hot urination, order closes and blood vessel is filled with eyeball, and deep-rolling pulse is really done one's bit inside; yellowish fur on the tongue tongue is dry; or scorching tongue is black very plays the diseases such as thorn, therefore reach heat with Baihu Tang, goes out to show, and makes it heat and goes to faint back.
But it should be noted that and occur clinically cold limbs due to intense heat in the interior, belong to disease deeply with the passing of time more, because lying prostrate in pathogenic heat, also visible abdominal distention tenderness, does not defecate and waits excess syndrome caused by interior-heat card, and, when capturing internal organs reality with holding gas, removing burning wood away under the boiler, expels the heat-evil to control and faint.Therefore can not stick to the established practice with Baihu Tang.In a word, the heat of cold limbs due to intense heat in the interior is this, and fainting is mark, and heat is the starting point of pathogenesis, and fainting is outer time illusion, is real heat with pseudo-cold, should carefully distinguish.In addition, also must be pointed out,, though disease soon, also can there is the syndrome of coldness on the extremities caused by blockage of excessive heat of " rolling pulse with coldness on the extremities " in infantile hyperpyrexia clinically, as infantile pneumonia, pathogenic heat is gathered lung, rough panting, but that brothers faint is cold, and fingerprint is livid purple and stagnant, also belong to the card of fainting, control when the suitable lung of heat clearing away, reach heat and go out, its runback of fainting.As acute infectious diseases such as acute bacillary dysentery, epidemic encephalitis type B, epidemic cerebrospinal meningitis, all can there is cold limbs due to intense heat in the interior in him, when clearly dialectical, because card treats.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of cure rate high, the safe and reliable Chinese medicine composition that is used for the treatment of typhoid fever cold limbs due to intense heat in the interior disease.
Technical problem to be solved by this invention realizes by the following technical solutions:
A Chinese medicine composition that is used for the treatment of typhoid fever cold limbs due to intense heat in the interior disease, the medicament of being made by the crude drug of following weight,
Radix Bupleuri 10-20g, Radix Paeoniae Alba 10-20g, Fructus Aurantii Immaturus 5-15g, Radix Scutellariae 8-14g, Caulis Akebiae 5-15g, Flos Carthami 1-10g, Radix Glycyrrhizae 5-15g.
The preferred weight of each component is:
Radix Bupleuri 15g, Radix Paeoniae Alba 15g, Fructus Aurantii Immaturus 10g, Radix Scutellariae 12g, Caulis Akebiae 10g, Flos Carthami 5g, Radix Glycyrrhizae 10g.
The preferred ingredient of each component is:
Soft Radix Bupleuri 15g, Radix Paeoniae Alba 15g, Fructus Aurantii Immaturus (parched) 10g, Radix Scutellariae 12g, Chinese Caulis Akebiae 10g, Flos Carthami 5g, Radix Glycyrrhizae 10g.
The present invention's crude drug used can be bought and obtain from common Chinese shop, and its specification meets national Chinese crude drug standard.
Chinese medicine composition of the present invention can add various adjuvants required while preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., with conventional method of Chinese medicinal, be prepared into any conventional oral formulations, wherein, described oral formulations can be decoction, pill, capsule or tablet.
Another object of the present invention is to provide a kind of method of preparing the present composition, comprises the steps,
1) by following weight number, take each crude drug: soft Radix Bupleuri 15g, Radix Paeoniae Alba 15g, Fructus Aurantii Immaturus (parched) 10g, Radix Scutellariae 12g, Chinese Caulis Akebiae 10g, Flos Carthami 5g, Radix Glycyrrhizae 10g.
2) above-mentioned each taste material medicine is mixed be placed on and in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction.
Usage and consumption:
The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as age of patient, body weight, health status.Instruction: decoction, 1 dose of every day, decocting, minute morning, noon and afternoon clothes, know for 1 dose, and 2 doses are light, and 3 doses of work, rest 3, as usual and fully recover from an illness.
By Cheng Wuji day: " if all, faint and begin to obtain it, just brothers faint and warm person, is that yin channel is subject to heresy, YANG QI deficiency, available decoction for Resuscitation, if brothers' self-heating and the temperature that arrives, from the contrary and person of fainting that arrives, the heresy of transmission from one channel to another also, Sini San master it." this cold limbs due to intense heat in the interior disease, therefore thin its wood of Radix Bupleuri is strongly fragrant in side, Radix Paeoniae is led to its constipation of YIN type, the fire of the clear three warmers of Radix Scutellariae, and it is cold that Fructus Aurantii Immaturus is let out its painful abdominal mass, and gas during Radix Glycyrrhizae is in harmonious proportion, adds Caulis Akebiae and declares its latent heat, and Flos Carthami promoting the circulation of blood feeling pulse becomes silted up, and interior relieving the exterior syndrome reaches, and blood vessels pass unimpeded, and yang-energy is happy, and cold limbs due to intense heat in the interior spontaneous recovery.
Medicated diet prepared by the present invention has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and treatment disease, and the use link that this medicine is dropped into treatment disease provides science and objective foundation.Its test method and result of the test are as follows respectively:
1. the medicated diet that couple the present invention boils carries out animal acute toxicity test:
Medicine: the decoction being boiled by prescription of the present invention, saving backup ，You The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine in refrigerator provides.
Experimental animal: white mice, body weight is at 30-50g, and male and female select ，You Medical University Of Anhui to provide at random.
Method and result: get 50 of white mice, be divided into 5 groups, 10 every group, hungry about 15 hours, by every each 5ml, fill with medicine feed thing, in 24 hours, fill with respectively medicine feed thing 1,2,3,4,5 times, observe 5 days for the 1st, 2,3,4,5 groups, white mice is movable normal, and non-toxic reaction, without dead.Wherein white mice dosage is calculated by kg body weight dose, shows that oral liquid is without acute toxicity, clinical medicine dose safety.
2. the decoction that couple the present invention boils carries out long-term toxicity test for animals:
Experimental animal: rat, body weight, at 120-130g, all selects male white rat ，You Medical University Of Anhui to provide.
Method and result: get 50 of rat, be divided into 5 groups, every group 10, wherein the 1st, 2, 3, 4 groups as administration group, fill with respectively medicine feed thing 4ml for every group, 6ml, 8ml, 10ml, the 5th group of normal feeding as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the variation of tissues observed form, observe the effect of dosage, observe diet, movable variation, experimental results show that administration group and matched group are relatively without significant change, the visible kg body weight of pressing is calculated the equal non-toxic reaction of dosage doubly with respect to clinical 50-200, a kind of safe drugs.
3. in order to verify clinical efficacy, this prescription Jieshou City institute of traditional Chinese medicine tries out, and by choosing at random wherein 50 routine patients, the course for the treatment of is the shortest 1 day, and the longest is 5 days.
4. Therapeutic Method
According to drug ratios of the present invention, take raw material (dosage), according to the method for conventionally boiling medicine, obtain medicinal liquid, every day potion, the morning, noon and afternoon service once.
5. efficacy determination: adopt grade III Standard;
Effective 40 examples (subjective symptoms all disappears), effective 8 examples (subjective symptoms is obviously improved); Invalid 2 examples (subjective symptoms is without improving); Total effective rate 96%.
The invention has the beneficial effects as follows: the present invention draws materials easily, makes the features such as simple, with low cost, compatibility is reasonable, and taking dose is little, and Harmful ingredient content is low, has no side effect, evident in efficacy.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach object and effect is easy to understand, below in conjunction with specific embodiment, further set forth the present invention.
Embodiment 1
By following weight number, take each crude drug: Radix Bupleuri 15g, Radix Paeoniae Alba 15g, Fructus Aurantii Immaturus 10g, Radix Scutellariae 12g, Caulis Akebiae 10g, Flos Carthami 5g, Radix Glycyrrhizae 10g.
Above-mentioned each taste material medicine is mixed to be placed in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction.Instruction: decoction, get a pair and take herb liquid, three times on the one, morning, noon and afternoon sub-service, serve on 3 days.
Embodiment 2
By following weight number, take each crude drug: Radix Bupleuri 16g, Radix Paeoniae Alba 16g, Fructus Aurantii Immaturus 11g, Radix Scutellariae 13g, Caulis Akebiae 11g, Flos Carthami 6g, Radix Glycyrrhizae 11g.
Above-mentioned each taste material medicine is mixed to be placed in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction.Instruction: decoction, get a pair and take herb liquid, three times on the one, morning, noon and afternoon sub-service, serve on 3 days.
Embodiment 3
By following weight number, take each crude drug: Radix Bupleuri 14g, Radix Paeoniae Alba 14g, Fructus Aurantii Immaturus 9g, Radix Scutellariae 11g, Caulis Akebiae 9g, Flos Carthami 4g, Radix Glycyrrhizae 9g.
Above-mentioned each taste material medicine is mixed to be placed in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction.Instruction: decoction, get a pair and take herb liquid, three times on the one, morning, noon and afternoon sub-service, serve on 3 days.
Embodiment 4
By following weight number, take each crude drug: Radix Bupleuri 10g, Radix Paeoniae Alba 10g, Fructus Aurantii Immaturus 5g, Radix Scutellariae 8g, Caulis Akebiae 5g, Flos Carthami 1g, Radix Glycyrrhizae 5g.
Above-mentioned each taste material medicine is mixed to be placed in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction.Instruction: decoction, get a pair and take herb liquid, three times on the one, morning, noon and afternoon sub-service, serve on 3 days.
Model case
Case 1
Chen, man, is past sixty years of age, people from Jieshou City, Anhui Province.Just medical on July 11st, 2012, patient have latent heat, and excessively, sense body is sour in work in midsummer, and aversion to cold, is intended to sweating and exempts from medicine from taking Herba Alii fistulosi ginger decoction, then sends out headache to evening.Front doctor's mistaken diagnosis doctor anemopyretic cold, heavy lapidation cream, the Radix Rehmanniae, Radix Ophiopogonis and so on, counter the exacerbating of disease on the three more, deadly cold hand and foot, uncomfortable in chest, syncope, if ear without news, hundred lips are all white, only henna work, tongue fur is deep yellow, all volts in arteries and veins left and right and strong.It is critical that card belongs to, and front doctor wrongly takes the solidifying product of sweet Han Yin, holds back Re Guer.Plan is examined: typhoid fever syndrome of coldness on the extremities caused by blockage of excessive heat.Fa Dangda is strongly fragrant to activate yang, and a surname's painful abdominal mass expels the heat-evil.Take the embodiment of the present invention 1 water decoction, within 3 days, cure.
Case 2
Power people from Jieshou City of Mou， Nan，35， Anhui Province.The conscious body acid of patient, aversion to cold, is intended to sweating and exempts from medicine from taking Herba Alii fistulosi ginger decoction, then sends out headache to evening.Diagnosis: if ear without news, hundred lips are all white, only henna work, tongue fur is deep yellow, all volts in about arteries and veins and strong.It is critical that card belongs to, and intends examining: typhoid fever syndrome of coldness on the extremities caused by blockage of excessive heat.Fa Dangda is strongly fragrant to activate yang, and a surname's painful abdominal mass expels the heat-evil.Take the embodiment of the present invention 1 water decoction, within 3 days, cure.
Case 3
People from Jieshou City of Lee Mou， Nv，55， Anhui Province.The conscious body acid of patient, aversion to cold; Diagnosis: if ear without news, hundred lips are all white, only henna work, tongue fur is deep yellow, all volts in about arteries and veins and strong.It is critical that card belongs to, and intends examining: typhoid fever syndrome of coldness on the extremities caused by blockage of excessive heat.Fa Dangda is strongly fragrant to activate yang, and a surname's painful abdominal mass expels the heat-evil.Take the embodiment of the present invention 1 water decoction, within 3 days, cure.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (3)
1. a Chinese medicine composition that is used for the treatment of typhoid fever cold limbs due to intense heat in the interior disease, is characterized in that: the crude drug by following weight forms,
Radix Bupleuri 10-20g, Radix Paeoniae Alba 10-20g, Fructus Aurantii Immaturus 5-15g, Radix Scutellariae 8-14g, Caulis Akebiae 5-15g, Flos Carthami 1-10g, Radix Glycyrrhizae 5-15g.
2. a kind of Chinese medicine composition that is used for the treatment of typhoid fever cold limbs due to intense heat in the interior disease according to claim 1, is characterized in that: the crude drug by following weight forms,
Radix Bupleuri 15g, Radix Paeoniae Alba 15g, Fructus Aurantii Immaturus 10g, Radix Scutellariae 12g, Caulis Akebiae 10g, Flos Carthami 5g, Radix Glycyrrhizae 10g.
3. a kind of Chinese medicine composition that is used for the treatment of typhoid fever cold limbs due to intense heat in the interior disease according to claim 2, is characterized in that: the crude drug by following weight forms,
Soft Radix Bupleuri 15g, Radix Paeoniae Alba 15g, Fructus Aurantii Immaturus (parched) 10g, Radix Scutellariae 12g, Chinese Caulis Akebiae 10g, Flos Carthami 5g, Radix Glycyrrhizae 10g.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771628A (en) * | 2015-04-07 | 2015-07-15 | 陆开云 | Traditional Chinese medicine preparation for treating typhoid fever and heat syncope |
| CN105434616A (en) * | 2014-09-19 | 2016-03-30 | 李玉兰 | Traditional Chinese medicine composition treating typhoid |
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2013
- 2013-11-19 CN CN201310582551.9A patent/CN103610801B/en not_active Expired - Fee Related
Patent Citations (4)
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| CN1416880A (en) * | 2002-11-27 | 2003-05-14 | 北京中医药大学 | New use of powder for regulating liver and spleen and its active part |
| CN1430999A (en) * | 2003-01-28 | 2003-07-23 | 南京师范大学 | Chinese herbal medicine combination for treating disease of disorder of bowels's function and its product |
| EP2172207A1 (en) * | 2007-08-02 | 2010-04-07 | Tianjin Tasly Pharmaceutical Co. Ltd. | A pharmaceutical composition for treating diabetes and its process for preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434616A (en) * | 2014-09-19 | 2016-03-30 | 李玉兰 | Traditional Chinese medicine composition treating typhoid |
| CN104771628A (en) * | 2015-04-07 | 2015-07-15 | 陆开云 | Traditional Chinese medicine preparation for treating typhoid fever and heat syncope |
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