CN103610775B - A kind of medicine pill preparation method for the treatment of acute tonsillitis, acute pyogenic infection of skin - Google Patents
A kind of medicine pill preparation method for the treatment of acute tonsillitis, acute pyogenic infection of skin Download PDFInfo
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Abstract
The invention discloses a kind of medicine pill preparation method for the treatment of acute tonsillitis, acute pyogenic infection of skin, comprise the following steps of carrying out successively: the raw material pressing row weight portion is prepared burden: Borax (forging) 25 ~ 35 parts, Rhizoma Coptidis 15 ~ 25 parts, Galla Chinensis 2 ~ 4 parts, Concha 1 ~ 2 part, Margarita 1 ~ 2 part, Herba Asari 3 ~ 9 parts, artificial Calculus Bovis 2 ~ 4 parts, Borneolum Syntheticum 6 ~ 10 parts, Venenum Bufonis 8 ~ 12 parts, artificial Moschus 2 ~ 3 parts, Pulvis Cornus Bubali Concentratus 12 ~ 18 parts and Fel Ursi powder 0.5 ~ 1.5 part; Coarse crushing, be ground, Fel Ursi water processed, pill, plain ball are dry, select ball, the polishing of bag Pulvis Fumi Carbonisatus clothing, Pulvis Fumi Carbonisatus coated pill are dry and bag zein film-coat.Operation of the present invention is simple, medical material loss is little, can ensure that in every obtained pill, each component is all within the scope of prescription, the medicine pill adopting the present invention to prepare has effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, is applicable to treat laryngopharynx swelling and pain, single bilateral tonsillitis, carbuncle furuncle toxic swelling.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition preparation technology, specifically a kind of medicine pill preparation method for the treatment of acute tonsillitis, acute pyogenic infection of skin.
Background technology
Acute tonsillitis is exopathogen invasion and attack, and evil poison is jammed pharyngeal pharyngeal tonsils and cause the disease of pharyngeal pain, pharynx core redness, and disease causes manyly attacks lung meridian or exuberant lung-stomach heat because of heresy, is equivalent to the acute tonsillitis of modern medicine.Acute tonsillitis is one of clinical very common disease of pharynx, is also a part for common upper respiratory tract infection.Acute pyogenic infection of skin comprises furuncle, carbuncle, furuncle, cellulitis etc., it is local infection disease, the cause of disease can, stagnated fire malicious knot, damp and hot poison stagnant by wind heat poison accumulate and deficiency of YIN fire stagnant caused by, according to the different causes of disease, Chinese medical discrimination is divided into different pattern of syndrome: the stagnant disease of wind heat poison, stagnated fire poison combined symptoms, damp and hot poison accumulate disease and the stagnant disease of deficiency of YIN fire.
In the Chinese and western medicine medicine for the treatment of acute tonsillitis and acute pyogenic infection of skin, Chinese medicine side effect is little, is therefore more subject to the favor of people.Convenient in order to take, the Chinese medicine composition for the treatment of treatment acute tonsillitis and acute pyogenic infection of skin is prepared into pill by people usually.The Chinese medicine composition of existing treatment acute tonsillitis and acute pyogenic infection of skin is no lack of famous and precious Chinese crude drug, usually traditional mode is adopted to carry out pulverizing and mixing when the Chinese medicine composition pill of acute tonsillitis and acute pyogenic infection of skin is treated in preparation now, medical material waste is large, cost is high, and can not ensure that in every the pill obtained, each component is all within the scope of prescription.
Summary of the invention
The object of the present invention is to provide a kind of medicine pill preparation method for the treatment of acute tonsillitis, acute pyogenic infection of skin, the method has simple operation, coherent characteristic, be convenient to continuous prodution, medical material loss is little, and can ensure that in every obtained pill, each component is all within the scope of prescription; The medicine pill adopting the method to prepare, has effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, is applicable to treat laryngopharynx swelling and pain, single bilateral tonsillitis, carbuncle furuncle toxic swelling.
Object of the present invention is achieved through the following technical solutions: a kind of medicine pill preparation method for the treatment of acute tonsillitis, acute pyogenic infection of skin, comprises the following steps:
Step one, the raw material pressing row weight portion are prepared burden: Borax (forging) 25 ~ 35 parts, Rhizoma Coptidis 15 ~ 25 parts, Galla Chinensis 2 ~ 4 parts, Concha 1 ~ 2 part, Margarita 1 ~ 2 part, Herba Asari 3 ~ 9 parts, artificial Calculus Bovis 2 ~ 4 parts, Borneolum Syntheticum 6 ~ 10 parts, Venenum Bufonis 8 ~ 12 parts, artificial Moschus 2 ~ 3 parts, Pulvis Cornus Bubali Concentratus 12 ~ 18 parts and Fel Ursi powder 0.5 ~ 1.5 part;
Step 2, Borax (forging), Rhizoma Coptidis, Galla Chinensis, Concha, Margarita, Herba Asari are carried out coarse crushing and obtain coarse powder;
Step 3, coarse powder coarse crushing in artificial Calculus Bovis, Borneolum Syntheticum, Venenum Bufonis, artificial Moschus, Pulvis Cornus Bubali Concentratus and step 2 obtained drop into grinding in grinder and obtain fine powder after mixing, then are mixed by all powder after grinding;
Step 4, Fel Ursi powder to be added water, make Fel Ursi water;
Step 5, add in rustless steel sugar coating machine make plain ball by being ground the Fel Ursi water made in rear fine powder and step 4 in step 3;
Step 6, plain ball is dry;
Step 7, adopt medicine to screen on dried plain ball, select the qualified plain ball that aperture is 1.7 ~ 2.0mm.The following operation that step one of the present invention is carried out respectively to step 7: batching, coarse crushing, be ground, Fel Ursi water processed, pill, plain ball are dry and select ball, wherein, step 2, to the order interchangeable of step 3 and step 4, also can be carried out simultaneously.Grinding in the present invention is carried out in grinder, mixing is carried out in three-dimensional motion mixer, for the defective plain ball filtered out in step 7, the too small pill of particle diameter again can add in rustless steel sugar coating machine and strengthens molding, and special-shaped ball and excessive pill available water furnishing magma are again for pill.
Further, the raw material pressing row weight portion in described step one is prepared burden: Borax (forging) 30 parts, Rhizoma Coptidis 20 parts, Galla Chinensis 3 parts, Concha 2 parts, Margarita 2 parts, Herba Asari 5 parts, artificial Calculus Bovis 3 parts, Borneolum Syntheticum 8 parts, Venenum Bufonis 10 parts, artificial Moschus 3 parts, Pulvis Cornus Bubali Concentratus 15 parts and Fel Ursi powder 1 part.
Further, in described step 4, the concrete steps of Fel Ursi water processed are: the Fel Ursi powder after batching is put into container, and the boiling water adopting the water of Fel Ursi powder weight 3 ~ 9 times to be heated into dissolves Fel Ursi powder, and agitato vase dissolves completely to Fel Ursi powder gently, makes Fel Ursi water.
Further, make plain ball in described step 5 to comprise the following steps:
Step 5.1, the fine powder of fine powder gross weight 7% ~ 13% got in step 3 after ground and mixed put into rustless steel sugar coating machine, then add water by the form of spraying in rustless steel sugar coating machine, in rustless steel sugar coating machine, form rough pill;
Step 5.2, in rustless steel sugar coating machine, add the fine powder after being ground, and adopt the mode of spraying in rustless steel sugar coating machine, add the Fel Ursi water prepared, pill is continued to increase.In step 5.2, treat that Fel Ursi water adds in backward rustless steel sugar coating machine and spray water, until most of pill reaches particle diameter between 1.8 ~ 2.0mm in rustless steel sugar coating machine.Wherein, adding water in rustless steel sugar coating machine, add powder and should be suitable for, make pill keep hardness and roundness evenly to increase, until reach the pill of demand.It is because the recipe quantity of Fel Ursi powder is considerably less that the present invention selects Fel Ursi powder to add when pill, if directly ground and mixed together with other medical materials, its uniformity in medicated powder by the gross cannot be ensured, and Fel Ursi powder to be dissolved in water and spray uniformly in the mode of atomization when general ball, ensure that its uniformity of dosage units.
Further, a kind of medicine pill preparation method for the treatment of acute tonsillitis, acute pyogenic infection of skin, further comprising the steps of:
Steps A, the qualified plain ball selected is put into rustless steel sugar coating machine bag Pulvis Fumi Carbonisatus clothing, and in rustless steel sugar coating machine, make pill friction to surface-brightening;
Step B, the pill of bag Pulvis Fumi Carbonisatus clothing is dry;
Step C, the pill of the dried Pulvis Fumi Carbonisatus of bag clothing is put into rustless steel sugar coating machine, make thick solution by adding ethanol in zein, and this thick solution is sprayed in rustless steel sugar coating machine, make it be sprinkled upon pellet surface uniformly, discharging after ethanol volatilization, obtains medicinal finished product.The following operation that steps A of the present invention is carried out respectively to step C: the polishing of bag Pulvis Fumi Carbonisatus clothing, the drying of Pulvis Fumi Carbonisatus coated pill and bag zein film-coat.
Further, the drying of the bag Pulvis Fumi Carbonisatus clothing pill in described step 6 in the dry and step B of plain ball is vacuum dehydrating at lower temperature, and in step 5, the time of plain ball drying is 3 ~ 5 hours, and in described step B, the drying time of bag Pulvis Fumi Carbonisatus clothing pill is 8 ~ 10 hours.If carry out film coating to the present invention, wherein, the dried object of step 6 is convenient to screen pill, it needs to ensure pill hardness, so that in sieve ball process, pill there will not be pill to be out of shape, and the Pulvis Fumi Carbonisatus of bag clothing pill dry in step B completes the processing of pill substantially, only needs postorder to carry out film coating, therefore in step B, dry pill should ensure the aridity of pill entirety, so the drying time of step B is greater than the drying time in step 6.
Further, in described step B, bag Pulvis Fumi Carbonisatus clothing comprises the following steps: the qualified plain ball selected is put into rustless steel sugar coating machine, the form of spraying is adopted to add water in rustless steel sugar coating machine, make plain ball surface fully moistening, gradation adds Pulvis Fumi Carbonisatus again, and Pulvis Fumi Carbonisatus is evenly distributed on pill.
To adopt in the pill prepared of the present invention every 100 to nearly weigh 0.3g, pill entirety be the coated micropill of black, shows lark, the micro-perfume (or spice) of color after removing coating, bitter in the mouth, fiber crops, micro-pungent cool.Adopt the present invention prepare pill application time usage and consumption as follows: oral, be grown up one time 10; Children's one-year-old one time 1, two years old one time 2, three years old one time 3 ~ 4, four to eight years old one time 5 ~ 6, nine to ten five years old one time 7 ~ 9; 2 ~ 3 times on the one.External, at all furuncle furunculosis initial stages, the non-ulceration person of red and swollen heat pain, desirable more than 10 grains, tune into the melt with cold boiled water or vinegar, apply red and swollen surrounding, are coated with for several times day until swollenly to move back.
Compared with prior art, the present invention has following beneficial effect: (1) operation of the present invention comprises batching successively, is ground, Fel Ursi water processed, pill, plain ball are dry, select ball, the polishing of bag Pulvis Fumi Carbonisatus clothing, Pulvis Fumi Carbonisatus coated pill are dry and bag zein film-coat, overall operation is passed through repeatedly, simple operation, is convenient to serialization and produces in enormous quantities.
(2) Borax heat-clearing and toxic substances removing, sore-throat relievingization corruption in the medicine pill adopting the present invention to prepare, Rhizoma Coptidis clearing away heat-fire detoxifies, and Pulvis Cornus Bubali Concentratus clearing away heat,cooling blood and removing toxin is subsided a swelling, and three medicines are monarch drug altogether; Be aided with artificial Calculus Bovis's heat-clearing and toxic substances removing sore-throat relieving, Venenum Bufonis reducing swelling and alleviating pain, Fel Ursi powder heat-clearing and toxic substances removing, reducing swelling and alleviating pain, three medicines all kind heat-clearing and toxic substances removing, reducing swelling and alleviating pain, be ministerial drug altogether, coordinate monarch drug to strengthen effect of detoxification sore treatment, reducing swelling and alleviating pain; Help that partially cold and cool with Borneolum Syntheticum, pungent loose hardship is let out, fragrance is walked to alter, Moschus causing resuscitation with aromatic drugs passes through 12 warps, Margarita eliminating dampness and astringing sores, the detumescence of Galla Chinensis removing toxic substances astringing to arrest bleeding, Herba Asari falls apart wind cold relieving, understand things pain-stopping, Concha removing toxic substances, hemostasis, removing nebula, Pulvis Fumi Carbonisatus astringing to arrest bleeding, for making medicine, in pill prepared by the present invention, all medicines share, play effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain altogether, cure mainly laryngopharynx swelling and pain, single bilateral tonsillitis, carbuncle furuncle swells and ache, to reach clearing throat, conditioning lung system, gets rid of the object of virus, antibacterial and virus is all had to the inhibitory action of wide spectrum simultaneously.
(3) the present invention is prepared in the formula of pill containing artificial Moschus, Venenum Bufonis, Borneolum Syntheticum, the rare Chinese medicines such as artificial Calculus Bovis, in Borax (the easy moisture absorption) soluble in water and glycerol, can slow air slaking at air, Borneolum Syntheticum tool volatility, easy distillation, Venenum Bufonis is poisonous, feeble QI raw meat, taste just sweet then lasting spicy sense, what powder was smelt sneezes, if directly adopt traditional breaking method to pulverize, can to artificial Moschus, the rare Chinese medicines such as Borneolum Syntheticum cause certain loss, therefore the present invention grinds medical material when preparing pill in grinder, and be different from prior art required fine powder degree is directly crushed to medical material, so, dust pollution can be prevented, airtight nonhygroscopic, reduce waste of raw materials, avoid Venenum Bufonis broken time the intense stimulus sense (continuous sneeze) that brings to operator's respiratory tract, after grinding, fine powder degree improves (need not sieve), problem that before solving, the pill method of double differences is large (poisonous can not take) more, improve presentation quality, in the present invention, ball milling inherently has the effect of mixing, can ensure that in every obtained pill, each component is all within the scope of prescription.
(4) of the present invention in pelletizing process water with Fel Ursi water be all in mist spray, fine powder can be avoided like this to cross wet and cause pill shapeless, composition soluble in water can be avoided again to sink down into unnecessary moisture bottom material causes mixing of materials uneven, and then ensure that the uniformity of pill content.
(5) traditional many containing volatile ingredient, by heat-labile Chinese medicine preparation drying; the modes such as general employing is dried in the shade, silica gel static adsorption carry out drying; it is arid cycle long (general 20 ~ 30 days) not only, and drying effect is undesirable, is difficult to the needs adapting to the large production of scale.The present invention is prepared in the formula of pill containing Borneolum Syntheticum, the effumability compositions such as artificial Moschus, pill after the plain ball prepared the present invention by using vacuum dehydrating at lower temperature technology and bag Pulvis Fumi Carbonisatus clothing carries out drying, it is 3 ~ 5 hours to the time of the drying of plain ball, it is 8 ~ 10 hours to the time of the pill drying of bag Pulvis Fumi Carbonisatus clothing, compare traditional drying in the shade, the drying modes such as silica gel static adsorption drying times of 20 ~ 30 days, efficiency at least improves 30 times, improve production efficiency greatly, shorten the production cycle, also solve employing to dry in the shade, the drying mode floor spaces such as silica gel static adsorption are large, need workman repeatedly stir the problems such as pill.Adopt vacuum dehydrating at lower temperature technology, for the sensitive characteristic of Borneolum Syntheticum, artificial Moschus etc. in component of the present invention, science carry out cold drying, ensure that the stability of its physics and chemistry, and then ensure that the effectiveness of the pill prepared by the present invention.
Accompanying drawing explanation
Fig. 1 is process chart of the present invention.
Detailed description of the invention
Below in conjunction with embodiment and accompanying drawing, the present invention is described in further detail, but embodiments of the present invention are not limited thereto.
Embodiment 1
As shown in Figure 1, treat a medicine pill preparation method for acute tonsillitis, acute pyogenic infection of skin, comprise the following processing step carried out successively: batching, coarse crushing, be ground, Fel Ursi water processed, pill, plain ball are dry, select ball, the polishing of bag Pulvis Fumi Carbonisatus clothing, Pulvis Fumi Carbonisatus coated pill are dry and bag zein film-coat.
The concrete operations operation of batching is: the raw material pressing row weight portion is prepared burden: Borax (forging) 30 parts, Rhizoma Coptidis 20 parts, Galla Chinensis 3 parts, Concha 2 parts, Margarita 2 parts, Herba Asari 5 parts, artificial Calculus Bovis 3 parts, Borneolum Syntheticum 8 parts, Venenum Bufonis 10 parts, artificial Moschus 3 parts, Pulvis Cornus Bubali Concentratus 15 parts and Fel Ursi powder 1 part.
The concrete operations operation of coarse crushing is: adopt pulverizer to carry out coarse crushing Borax (forging), Rhizoma Coptidis, Galla Chinensis, Concha, Margarita and Herba Asari and obtain coarse powder.The concrete operations operation be ground is: mixed with artificial Calculus Bovis, Borneolum Syntheticum, Venenum Bufonis, artificial Moschus, Pulvis Cornus Bubali Concentratus by the coarse powder of Borax (forging), Rhizoma Coptidis, Galla Chinensis, Concha, Margarita and Herba Asari; drop into grinding in grinder again; if amount can be ground greatly in batches, then mix in all powder input three-dimensional motion mixer after grinding.
The concrete operations operation of Fel Ursi water processed is: the Fel Ursi powder after batching is put into container, and the boiling water adopting the water of Fel Ursi powder weight 3 ~ 9 times to be heated into dissolves Fel Ursi powder, and agitato vase dissolves completely to Fel Ursi powder gently, makes Fel Ursi water and cools.
The concrete operations operation of pill is: the fine powder getting the fine powder gross weight 7% ~ 13% after ground and mixed puts into rustless steel sugar coating machine, then adds water to rustless steel sugar coating machine, in rustless steel sugar coating machine, form rough pill; In rustless steel sugar coating machine, add the fine powder after being ground, and adopt the mode of spraying in rustless steel sugar coating machine, add the Fel Ursi water prepared, pill is continued to increase; Treat that Fel Ursi water adds in backward rustless steel sugar coating machine and spray into water, until most of pill reaches particle diameter between 1.8 ~ 2.0mm in rustless steel sugar coating machine.
The concrete operation of element ball drying is: plain ball is carried out vacuum dehydrating at lower temperature, and drying time is 3 ~ 5 hours, and the present embodiment preferred drying time is 4 hours.The concrete operation of ball is selected to be: to adopt medicine to screen on dried plain ball, select the qualified plain ball that aperture is 1.7 ~ 2.0mm.The concrete operations operation of bag Pulvis Fumi Carbonisatus clothing, polishing is: the qualified plain ball selected is put into rustless steel sugar coating machine, add water in rustless steel sugar coating machine, make plain ball surface fully moistening, gradation adds Pulvis Fumi Carbonisatus again, and Pulvis Fumi Carbonisatus is evenly distributed on pill, and in rustless steel sugar coating machine, make pill friction to surface-brightening, so repeatedly, until pellet sizes is even, color and luster is consistent, mellow and full, smooth.The concrete operations operation of Pulvis Fumi Carbonisatus coated pill drying is: the pill of bag Pulvis Fumi Carbonisatus clothing is carried out vacuum dehydrating at lower temperature, dry 8 ~ 10 hours, and the present embodiment preferred drying time is 9 hours.The concrete operations operation of bag zein film-coat is: the pill of the dried Pulvis Fumi Carbonisatus of bag clothing is put into rustless steel sugar coating machine, thick solution is made by adding ethanol in zein, and this thick solution is sprayed in rustless steel sugar coating machine, it is made to be sprinkled upon pellet surface uniformly, discharging after ethanol volatilization, obtains medicinal finished product.
The weight portion of preparing burden in the pill adopting the present invention to prepare is respectively: Borax (forging) 30 parts, Rhizoma Coptidis 20 parts, Galla Chinensis 3 parts, Concha 2 parts, Margarita 2 parts, Herba Asari 5 parts, artificial Calculus Bovis 3 parts, Borneolum Syntheticum 8 parts, Venenum Bufonis 10 parts, artificial Moschus 3 parts, Pulvis Cornus Bubali Concentratus 15 parts and Fel Ursi powder 1 part.
The effect that medicine pill prepared by the present invention has heat-clearing and toxic substances removing, reducing swelling and alleviating pain is further illustrated below by way of test.
One, animal experiment
According to " study of tcm new drug guide ", the pharmacodynamics of pill prepared by the present invention comprises the following aspects: the impact that the Chinese medicine composition observing various dose swells on Experimental Mice ear swelling, rat paw, mice thermostimulation and acetic acid stimulate.
1.1, mouse ear dimethylbenzene experiment
Animal: ICR mice (quality certification number: dynamic No. 001, the pipe word of river doctor), 18 ~ 22g, male and female half and half, are divided into 5 groups at random, often organize 10.
Medicine pill pulverization the present invention prepared, is made into 3mg crude drug/ml(high dose group with distilled water); Dosage group in 1mg crude drug/ml(); The suspension (low dose group) of 0.24mg crude drug/ml.
Method: high dose group, 0.5ml/20g, middle dosage group, 0.5ml/20g, low dose group, 0.5ml/20g, blank group (normal saline 0.5ml/20g) and positive controls (prednisone 20mg/kg), drip 1 melted paraxylene at the left ear of mice immediately after gavage l hour respectively, after 15 minutes, put to death animal, get the left and right ear of equal size at same position, precision takes weight, with left ear weight-auris dextra weight=ear difference heavily for Mus ear heavily rises in value calculating.The results are shown in Table 1.
Result shows through statistical procedures, and heavy dose of group mouse ear is heavily rised in value extremely remarkable in blank group (P<0.01), in, the left ear of small dose group mice heavily rises in value and is starkly lower than blank group (P<0.05).Illustrate that the mouse ear inflammation caused by Chinese medicine composition xylol of the present invention has obvious inhibitory action.
1.2, rat paw edema experiment
Animal: SD rat, (quality certification number, dynamic No. 001, the pipe word of river doctor)
Body weight: 150 ~ 250g, healthy rat male and female are not limit, and are divided into 5 groups at random, often organize 10.
Medicine pill pulverization the present invention prepared, makes the heavy dose of group of 15mg crude drug/ml(with distilled water), dosage group in 5mg crude drug/ml(), 1.2mg crude drug/ml(small dose group).
Method: select SD rat, is divided into the heavy dose of group of Chinese medicine composition of the present invention, 0.5ml/100g at random; Middle dosage group, 0.5ml/100g; Small dose group, 0.5ml/100g; Blank normal saline group 0.5ml/100g; Positive controls is prednisone 20mg/kg, by rat paw edema method, after measuring every rat with capillary tube method, ankle is to ankle volume, then gastric infusion is distinguished, after 1 hour in rat rear foot ankle subcutaneous injection 10% fresh albumen 0.lml/ only, then measure rat toe place volume respectively at 0.5 hour, 1 hour, 2 hours, 4 hours, with foot volume differences before and after administration for pedal swelling degree, observe the difference between matched group and administration group.The results are shown in Table 2.
Compared with matched group,
*p<0.05,
*p<0.01, result show only the present invention heavy dose of 1 hour rat paw edema degree compared with matched group, extremely remarkable in matched group, illustrate that pharmaceutical composition of the present invention swells to rat foot caused by Ovum Gallus domesticus album and has obvious inhibitory action when heavy dose, but acting duration is not long.
1.3, mouse hot-plate test
Animal: ICR mice (the animal quality certification, dynamic No. 001, the pipe word of river doctor), 100, female 18 ~ 20g.
Medicine pill pulverization the present invention prepared, makes the heavy dose of group of 3mg crude drug/ml(with distilled water), dosage group in lmg crude drug/ml(), 0.24mg crude drug/ml(small dose group) suspension.
Method: put by ICR mice on the hot plate being heated to 55 ± 0.5 DEG C, first surveys the wealthy value of normal pain, to lick metapedes for pain indicator reaction, surveys 2 times altogether, 5 minutes, interval.Select the mice that 2 averages are no more than 30 seconds, be divided into 5 groups at random by body weight, heavy dose of group, 0.5ml/20g; Middle dosage group 0.5ml/20g; Small dose group 0.5ml/20g, blank group, normal saline 0.5ml/20g; Positive drug control group, morphine hydrochloride 1mg/ml, 0.5ml/20g, respectively gastric infusion, the pain threshold of 20min, 40min, 60min, 120min after survey administration.The results are shown in Table 3.
Compared with before administration:
*p<0.05,
*p<0.01, result is through statistics, 40min, 60min, 120min after heavy dose of group medicine, all pole is had to significantly improve (P<0.01) compared with the wealthy value of matched group pain, in, after small dose group administration 40min, 60min, 120 people all comparatively blank group pain threshold be significantly increased (P<0.05), after pharmaceutical composition administration 40min of the present invention is described, there is significant analgesic activity to mice thermostimulation pain and acting duration is long.
Two, clinical efficacy
2.1, data and method
Medicine:
Treatment group: oral dose: 1 time 10, warm water is swallowed, 2 times on the 1st
Matched group: six clever balls, Tengchong Pharmaceutical Plant, Yunnan Province produce, authentication code: Z53020630, lot number: 071025, oral dose: 1 time 10, buccal, 2 times on the 1st.
Clinical test results is in table 4 ~ 5.
Two groups of treatments are put through statistical procedures, no significant difference, illustrate that two groups of acute tonsillitis (acute tonsillitis) total effectses are similar.
Two groups of curative effects are through statistical procedures, and no significant difference, illustrates that the tcm syndrome curative effect of two groups of treatments acute tonsillitis (acute tonsillitis) is similar.
3.3, treatment acute pyogenic infection of skin (furuncle, carbuncle) clinical test results in table 6 ~ 7.
Two groups of curative effects are through statistical procedures, and no significant difference, the total effects of two groups of Drug therapy acute pyogenic infection of skin is similar.
Two groups of curative effects are through statistical procedures, and no significant difference, the tcm syndrome curative effect of two groups of Drug therapy acute pyogenic infection of skin is similar.
Conclusion: medicine pill prepared by the present invention has that heat-clearing and toxic substances removing, pain relieving, effect of detumescence and good effect, short treating period, pathogenic fire reducing, antiinflammatory, pain relieving are fast, symptom disappears substantially in 3 days.
Embodiment 2
The present embodiment is the different of burden process from the difference of embodiment 1, and the present embodiment is prepared burden by the raw material of following weight portion when preparing burden: Borax (forging) 25 parts, Rhizoma Coptidis 25 parts, Galla Chinensis 2 parts, Concha 1 part, Margarita 1 part, Herba Asari 6 parts, artificial Calculus Bovis 2 parts, Borneolum Syntheticum 10 parts, Venenum Bufonis 8 parts, artificial Moschus 2.5 parts, Pulvis Cornus Bubali Concentratus 12 parts and Fel Ursi powder 0.5 part.Medicine pill prepared by the present embodiment adopts the test method of embodiment 1 to carry out animal experiment, the impact that the Chinese medicine composition observing various dose swells on Experimental Mice ear swelling, rat paw, mice thermostimulation and acetic acid stimulate, and carried out clinical trial, test proves that the medicine pill prepared of the present embodiment has effect of heat-clearing and toxic substances removing, pain relieving, detumescence, and good effect, short treating period, pathogenic fire reducing, antiinflammatory, pain relieving are fast.
Embodiment 3
The present embodiment is the different of burden process from the difference of embodiment 1, and the present embodiment is prepared burden by the raw material of following weight portion when preparing burden: Borax (forging) 35 parts, Rhizoma Coptidis 15 parts, Galla Chinensis 4 parts, Concha 1.5 parts, Margarita 1.5 parts, Herba Asari 4 parts, artificial Calculus Bovis 4 parts, Borneolum Syntheticum 6 parts, Venenum Bufonis 12 parts, artificial Moschus 2 parts, Pulvis Cornus Bubali Concentratus 18 parts and Fel Ursi powder 1.5 parts.Medicine pill prepared by the present embodiment adopts the test method of embodiment 1 to carry out animal experiment, the impact that the Chinese medicine composition observing various dose swells on Experimental Mice ear swelling, rat paw, mice thermostimulation and acetic acid stimulate, and carried out clinical trial, test proves that the medicine pill prepared of the present embodiment has effect of heat-clearing and toxic substances removing, pain relieving, detumescence, and good effect, short treating period, pathogenic fire reducing, antiinflammatory, pain relieving are fast.
Above content is the further description done the present invention in conjunction with concrete preferred implementation, can not assert that the specific embodiment of the present invention is confined to these explanations.For general technical staff of the technical field of the invention, not departing from other embodiments drawn under technical scheme of the present invention, all should be included in protection scope of the present invention.
Claims (7)
1. treat a medicine pill preparation method for acute tonsillitis, acute pyogenic infection of skin, it is characterized in that, comprise the following steps:
Step one, the raw material pressing row weight portion are prepared burden: Borax(calcined) 25 ~ 35 parts, Rhizoma Coptidis 15 ~ 25 parts, Galla Chinensis 2 ~ 4 parts, Concha 1 ~ 2 part, Margarita 1 ~ 2 part, Herba Asari 3 ~ 9 parts, artificial Calculus Bovis 2 ~ 4 parts, Borneolum Syntheticum 6 ~ 10 parts, Venenum Bufonis 8 ~ 12 parts, artificial Moschus 2 ~ 3 parts, Pulvis Cornus Bubali Concentratus 12 ~ 18 parts and Fel Ursi powder 0.5 ~ 1.5 part;
Step 2, Borax(calcined), Rhizoma Coptidis, Galla Chinensis, Concha, Margarita, Herba Asari are carried out coarse crushing and obtain coarse powder;
Step 3, coarse powder coarse crushing in artificial Calculus Bovis, Borneolum Syntheticum, Venenum Bufonis, artificial Moschus, Pulvis Cornus Bubali Concentratus and step 2 obtained drop into grinding in grinder and obtain fine powder after mixing, then are mixed by all powder after grinding;
Step 4, Fel Ursi powder to be added water, make Fel Ursi water;
Step 5, add in rustless steel sugar coating machine make plain ball by being ground the Fel Ursi water made in rear fine powder and step 4 in step 3;
Step 6, plain ball is dry;
Step 7, adopt medicine to screen on dried plain ball, select the qualified plain ball that aperture is 1.7 ~ 2.0mm.
2. a kind of medicine pill preparation method for the treatment of acute tonsillitis, acute pyogenic infection of skin according to claim 1; it is characterized in that, the raw material pressing row weight portion in described step one is prepared burden: Borax(calcined) 30 parts, Rhizoma Coptidis 20 parts, Galla Chinensis 3 parts, Concha 2 parts, Margarita 2 parts, Herba Asari 5 parts, artificial Calculus Bovis 3 parts, Borneolum Syntheticum 8 parts, Venenum Bufonis 10 parts, artificial Moschus 3 parts, Pulvis Cornus Bubali Concentratus 15 parts and Fel Ursi powder 1 part.
3. a kind of medicine pill preparation method for the treatment of acute tonsillitis, acute pyogenic infection of skin according to claim 1, it is characterized in that, in described step 4, the concrete steps of Fel Ursi water processed are: the Fel Ursi powder after batching is put into container, the boiling water adopting the water of Fel Ursi powder weight 3 ~ 9 times to be heated into dissolves Fel Ursi powder, agitato vase dissolves completely to Fel Ursi powder gently, makes Fel Ursi water.
4. a kind of medicine pill preparation method for the treatment of acute tonsillitis, acute pyogenic infection of skin according to claim 1, is characterized in that, make plain ball and comprise the following steps in described step 5:
Step 5.1, the fine powder of fine powder gross weight 7% ~ 13% got in step 3 after ground and mixed put into rustless steel sugar coating machine, then add water by the form of spraying in rustless steel sugar coating machine, in rustless steel sugar coating machine, form rough pill;
Step 5.2, in rustless steel sugar coating machine, add the fine powder after being ground, and adopt the mode of spraying in rustless steel sugar coating machine, add the Fel Ursi water prepared, pill is continued to increase.
5., according to a kind of medicine pill preparation method for the treatment of acute tonsillitis, acute pyogenic infection of skin in Claims 1 to 4 described in any one, it is characterized in that, further comprising the steps of:
Steps A, the qualified plain ball selected is put into rustless steel sugar coating machine bag Pulvis Fumi Carbonisatus clothing, and in rustless steel sugar coating machine, make pill friction to surface-brightening;
Step B, the pill of bag Pulvis Fumi Carbonisatus clothing is dry;
Step C, the pill of the dried Pulvis Fumi Carbonisatus of bag clothing is put into rustless steel sugar coating machine, make thick solution by adding ethanol in zein, and this thick solution is sprayed in rustless steel sugar coating machine, make it be sprinkled upon pellet surface uniformly, discharging after ethanol volatilization, obtains medicinal finished product.
6. a kind of medicine pill preparation method for the treatment of acute tonsillitis, acute pyogenic infection of skin according to claim 5, it is characterized in that, the drying of the bag Pulvis Fumi Carbonisatus clothing pill in described step 6 in the dry and step B of plain ball is vacuum dehydrating at lower temperature, in step 5, the time of plain ball drying is 3 ~ 5 hours, and in described step B, the drying time of bag Pulvis Fumi Carbonisatus clothing pill is 8 ~ 10 hours.
7. a kind of medicine pill preparation method for the treatment of acute tonsillitis, acute pyogenic infection of skin according to claim 5, it is characterized in that, in described step B, bag Pulvis Fumi Carbonisatus clothing comprises the following steps: the qualified plain ball selected is put into rustless steel sugar coating machine, the form of spraying is adopted to add water in rustless steel sugar coating machine, make plain ball surface fully moistening, gradation adds Pulvis Fumi Carbonisatus again, and Pulvis Fumi Carbonisatus is evenly distributed on pill.
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| CN1634490A (en) * | 2004-12-02 | 2005-07-06 | 北京正大绿洲医药科技有限公司 | Drop pills for treating throat diseases and preparation method thereof |
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| CN1634490A (en) * | 2004-12-02 | 2005-07-06 | 北京正大绿洲医药科技有限公司 | Drop pills for treating throat diseases and preparation method thereof |
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