CN103550816A - Preparation method for chitosan-based electrostatic spinning combined wound dressing - Google Patents
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Abstract
The invention discloses a preparation method for a chitosan-based electrostatic spinning combined wound dressing. The preparation method comprises the steps: (1) entirely dissolving a certain amount of chitosan into a 90% acetic acid solution, adding a certain amount of glycerol, then adding a lecithin and tea essential oil mixture solution prepared according to a certain proportion, and performing ultrasonic dispersion to obtain a spinning solution; (2) entirely dissolving a certain amount of chitosan into a 2% acetic acid solution, adding a certain amount of glycerol, and performing casting membrane forming to obtain a chitosan membrane; (3) applying a layer of chitosan membrane on an electrostatic spinning receiving slab, performing electrostatic spinning by adopting the spinning solution to obtain an essential oil chitosan fiber particle layer; (4) after electrostatic spinning is finished, covering a layer of chitosan membrane, performing compression moulding at a certain temperature to obtain the chitosan-based electrostatic spinning combined wound dressing. The dressing has durable and wide-spectrum antisepsis effects, as well as excellent controlled-release antisepsis and comfortable properties, is good in biocompatibility, has certain plant aroma, and can be widely applied in the fields of textile industry, health and medicine, and biomedicine and the like as a medical material, a textile garment material, an antisepsis material and the like.
Description
Technical field
The invention belongs to field of medical materials, be specifically related to a kind of preparation method of chitosan-based electrostatic spinning composite wound dressing.
Background technology
Chitosan is natural polymer biological polyoses de-acetyl chitin product; there is good solvent resistance and alkali resistance; good biocompatibility and skin affinity; biocidal property, film property, breathability, water absorption, moisture retention are good; can stop blooding, promote the advantages such as wound healing to can be used as medical material.But because chitosan fragility is large, poor mechanical property, makes it use and be restricted separately.At present, there are lot of documents chitosan and other polymer blended modification to make the dressing membrane of function admirable.Introduce other macromolecule compared with pure chistosan film, some performance can be affected.Electrostatic spinning technique is to realize one of main path that chitosan applies in field of medicaments.But because the dissolubility of chitosan is little, only can be dissolved in dilute acid solution, solution stickiness is very high and be the characteristic of polycation electrolyte, and chitosan solution has very high viscosity, increased the difficulty that electrospinning is prepared pure chitosan nano fibrous membrane.Pure chitosan nanofiber diameter generally arrives between hundreds of nanometers at tens nanometer, and its film has very high specific surface area, is applicable to doing slow-release material.
Tea tree ethereal oil, is the oiliness extract that Australia Melaleuca Alternifolia vanes vapor distillation obtains, and has special aromatic odor.Tea tree ethereal oil has significant bacteriostatic activity and antimicrobial spectrum scope widely, common gram positive bacteria, gram negative bacteria and fungus are all had to strong inhibitory action, compare the unique advantage that side effect and residual toxicity are little with chemical antibacterial, skin is had no stimulation.Tea tree ethereal oil have purify air, sterilize, immune, anticorrosion, the purposes such as cytotrophy are provided, can be used as medical dressing antibacterial safely and effectively.
Therefore, the chitosan emulsion that employing contains tea tree ethereal oil emulsion droplet is carried out electrostatic spinning as spinning liquid, make quintessence oil chitin fiber granule rete, and be sandwiched between two high-comfort chitosan films and make chitosan-based electrostatic spinning composite wound dressing, there is important using value and development prospect.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of preparation method of chitosan-based electrostatic spinning composite wound dressing.
For solving the problems of the technologies described above, the technical solution used in the present invention is as follows:
A preparation method for chitosan-based electrostatic spinning composite wound dressing, comprises the steps:
(1) mixing and stirring in water by tea tree ethereal oil and lecithin, ultrasonic dispersion is degassed, makes quintessence oil emulsion;
(2) chitosan is dissolved in 90% acetic acid solution, adds glycerol as plasticizer, add quintessence oil emulsion, stirring at room, to dissolving completely, makes spinning liquid;
(3) chitosan is dissolved in 2% acetic acid solution, adds glycerol as plasticizer, stirring at room, to dissolving completely, makes film forming liquid, utilizes casting filming therapy to make chitosan film;
(4) chitosan film is coated on electrostatic spinning dash receiver, utilizes spinning liquid to carry out electrostatic spinning, obtain quintessence oil chitin fiber granular layer.
(5) after electrostatic spinning completes, then one deck chitosan film is covered on quintessence oil chitin fiber granular layer, compressingly at a certain temperature obtain chitosan-based electrostatic spinning composite wound dressing.
In step (1), the ratio of tea tree ethereal oil (ml), lecithin (g) and water (ml) is 0.5～1:0.1～0.2:0.5～1.0.
In step (2) and (3), the specification of chitosan is that viscosity-average molecular weight is 5.0 * 10
5, deacetylation is 80～85%.
In step (2), 90% acetic acid solution mass concentration of chitosan is 1.5～3%.The addition of glycerol is 2～4%, and the addition of quintessence oil emulsion is 2～4%.
In step (3), 2% acetic acid solution mass concentration of chitosan is 1.5～2.5%.The addition of glycerol is 2～4%.
In step (4), electrostatic spinning specification of syringe is 10ml, and needle gauge is tack, No. 7 pins.
In step (4), electrostatic spinning condition is, voltage 12～20KV, distance 7～10cm, sample rate 0.3～1.0ml/h, 25～35 ℃ of temperature.
In step (5), first with 40～50 ℃ of compacting 10s, then suppress 10s with 100～120 ℃.
The preparation method of the chitosan-based electrostatic spinning composite wound dressing that the present invention obtains, can be used as medical material, textile garment material, anti-biotic material etc. and is widely used in the fields such as textile industry, medicines and health protection, biomedicine.
Beneficial effect: preparation method of the present invention compared with prior art, has the following advantages:
1, method of the present invention is simple to operate, and raw material is cheap and easy to get, consuming time less, can obtain at short notice the diameter of coated quintessence oil emulsion droplet and aperture at nano level chitosan film material;
2, the two large main materials that the present invention adopts are natural material: chitosan and tea tree ethereal oil.The wound dressing synthetic with other compared, its good biocompatibility, and environmental friendliness, does not add too much auxiliary agent, organic solvent, to human body skin yet nonirritant.
3, the chitosan-based electrostatic spinning composite wound dressing of preparation has certain plant fragrance taste, the abnormal flavour that wound suppuration produces can be to a certain degree hidden, the nervous of patient, relieving stress can also be accelerated to eliminate, pleasure, meets the spiritual enjoyment of people;
4, the outer chitosan film adopting through plastics processing of chitosan-based electrostatic spinning composite wound dressing, when supporting quintessence oil chitin fiber granular layer, its comfortableness also improves greatly, makes the dressing skin of more fitting.
Accompanying drawing explanation
Fig. 1 is principle schematic of the present invention.
The specific embodiment
According to following embodiment, the present invention may be better understood.Yet, those skilled in the art will readily understand, the described content of embodiment is only for the present invention is described, and should also can not limit the present invention described in detail in claims.
Embodiment 1:
A preparation method for chitosan-based electrostatic spinning composite wound dressing, comprises the steps:
(1) mixing and stirring in 0.5ml water by 0.5ml tea tree ethereal oil and 0.1g lecithin, ultrasonic dispersion is degassed, makes quintessence oil emulsion;
(2) by 0.75g chitosan, (viscosity-average molecular weight is 5.0 * 10
5, deacetylation is 80～85%) be dissolved in the acetic acid solution of 50ml90%, add 1ml glycerol as plasticizer, add 1ml quintessence oil emulsion, stirring at room, to dissolving completely, makes spinning liquid;
(3) 1g chitosan is dissolved in the acetic acid solution of 50ml2%, adds 1ml glycerol as plasticizer, stirring at room, to dissolving completely, makes film forming liquid, utilizes casting filming therapy to make chitosan film, takes off standby;
(4) chitosan film is coated on electrostatic spinning dash receiver, with 10ml syringe (7# tack pin), extract spinning liquid, be fixed on electrostatic spinning apparatus, fixing electrostatic pressure 20KV, receiving range is 7cm, sample rate is 0.3ml/h, at 25 ℃ of temperature, carries out electrospinning, obtains quintessence oil chitin fiber granular layer.
(5) after electrostatic spinning completes, then one deck chitosan film is covered on quintessence oil chitin fiber granular layer, first with 50 ℃ of compacting 10s, then with 120 ℃ of compacting 10s, obtain chitosan-based electrostatic spinning composite wound dressing.
Embodiment 2:
A preparation method for chitosan-based electrostatic spinning composite wound dressing, comprises the steps:
(1) mixing and stirring in 1ml water by 1ml tea tree ethereal oil and 0.2g lecithin, ultrasonic dispersion is degassed, makes quintessence oil emulsion;
(2) by 1.5g chitosan, (viscosity-average molecular weight is 5.0 * 10
5, deacetylation is 80～85%) be dissolved in the acetic acid solution of 50ml90%, add 2ml glycerol as plasticizer, add 2ml quintessence oil emulsion, stirring at room, to dissolving completely, makes spinning liquid;
(3) 1.25g chitosan is dissolved in the acetic acid solution of 50ml2%, adds 2ml glycerol as plasticizer, stirring at room, to dissolving completely, makes film forming liquid, utilizes casting filming therapy to make chitosan film, takes off standby;
(4) chitosan film is coated on electrostatic spinning dash receiver, with 10ml syringe (7# tack pin), extract spinning liquid, be fixed on electrostatic spinning apparatus, fixing electrostatic pressure 12KV, receiving range is 10cm, sample rate is 1ml/h, at 35 ℃ of temperature, carries out electrospinning, obtains quintessence oil chitin fiber granular layer.
(5) after electrostatic spinning completes, then one deck chitosan film is covered on quintessence oil chitin fiber granular layer, first with 40 ℃ of compacting 10s, then with 110 ℃ of compacting 10s, obtain chitosan-based electrostatic spinning composite wound dressing.
Embodiment 3:
A preparation method for chitosan-based electrostatic spinning composite wound dressing, comprises the steps:
(1) mixing and stirring in 0.75ml water by 0.75ml tea tree ethereal oil and 0.15g lecithin, ultrasonic dispersion is degassed, makes quintessence oil emulsion;
(2) by 1g chitosan, (viscosity-average molecular weight is 5.0 * 10
5, deacetylation is 80～85%) be dissolved in the acetic acid solution of 50ml90%, add 1.5ml glycerol as plasticizer, add 1.5ml quintessence oil emulsion, stirring at room, to dissolving completely, makes spinning liquid;
(3) 0.75g chitosan is dissolved in the acetic acid solution of 50ml2%, adds 0.75ml glycerol as plasticizer, stirring at room, to dissolving completely, makes film forming liquid, utilizes casting filming therapy to make chitosan film, takes off standby;
(4) chitosan film is coated on electrostatic spinning dash receiver, with 10ml syringe (7# tack pin), extract spinning liquid, be fixed on electrostatic spinning apparatus, fixing electrostatic pressure 15KV, receiving range is 8cm, sample rate is 0.5ml/h, at 30 ℃ of temperature, carries out electrospinning, obtains quintessence oil chitin fiber granular layer.
(5) after electrostatic spinning completes, then one deck chitosan film is covered on quintessence oil chitin fiber granular layer, first with 45 ℃ of compacting 10s, then with 100 ℃ of compacting 10s, obtain chitosan-based electrostatic spinning composite wound dressing.
Claims (8)
1. a preparation method for chitosan-based electrostatic spinning composite wound dressing, is characterized in that, comprises the steps:
(1) mixing and stirring in water by tea tree ethereal oil and lecithin, ultrasonic dispersion is degassed, makes quintessence oil emulsion;
(2) chitosan is dissolved in 90% acetic acid solution, adds glycerol as plasticizer, add quintessence oil emulsion, stirring at room, to dissolving completely, makes spinning liquid;
(3) chitosan is dissolved in 2% acetic acid solution, adds glycerol as plasticizer, stirring at room, to dissolving completely, makes film forming liquid, utilizes casting filming therapy to make chitosan film;
(4) chitosan film is coated on electrostatic spinning dash receiver, utilizes spinning liquid to carry out electrostatic spinning, obtain quintessence oil chitin fiber granular layer.
(5) after electrostatic spinning completes, then one deck chitosan film is covered on quintessence oil chitin fiber granular layer, compressingly at a certain temperature obtain chitosan-based electrostatic spinning composite wound dressing.
2. the preparation method of chitosan-based electrostatic spinning composite wound dressing according to claim 1, it is characterized in that, in step (1), the ratio of described tea tree ethereal oil (ml), lecithin (g) and water (ml) is 0.5～1:0.1～0.2:0.5～1.0.
3. the preparation method of chitosan-based electrostatic spinning composite wound dressing according to claim 1, is characterized in that, in step (2) and (3), the specification of chitosan used is viscosity-average molecular weight 5.0 * 10
5, deacetylation is 80～85%.
4. the preparation method of chitosan-based electrostatic spinning composite wound dressing according to claim 1, is characterized in that, in step (2), 90% acetic acid solution mass concentration of chitosan used is 1.5～3%.The addition of glycerol is 2～4%, and the addition of quintessence oil emulsion is 2～4%.
5. the preparation method of chitosan-based electrostatic spinning composite wound dressing according to claim 1, is characterized in that, in step (3), the viscosity-average molecular weight of chitosan used is 5.0 * 10
5, deacetylation is 80～85%, 2% acetic acid solution mass concentration of chitosan is 1.5～2.5%.The addition of glycerol is 2～4%.
6. the preparation method of chitosan-based electrostatic spinning composite wound dressing according to claim 1, is characterized in that, in step (4), electrostatic spinning specification of syringe is 10ml, and needle gauge is tack, No. 7 pins.
7. the preparation method of chitosan-based electrostatic spinning composite wound dressing according to claim 1, is characterized in that, in step (4), electrostatic spinning condition is, voltage 12～20KV, distance 7～10cm, sample rate 0.3～1.0ml/h, 25～35 ℃ of temperature.
8. the preparation method of chitosan-based electrostatic spinning composite wound dressing according to claim 1, is characterized in that, in step (5), first with 40～50 ℃ of compacting 10s, then suppresses 10s with 100～120 ℃.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103800939A (en) * | 2014-02-14 | 2014-05-21 | 武汉烺祺生物科技有限公司 | Antibacterial healing-functional dressing and preparation method thereof |
| CN104013450A (en) * | 2014-06-12 | 2014-09-03 | 张家港保税区冠祥贸易有限公司 | Tourniquet bandage |
| CN104069534A (en) * | 2014-06-12 | 2014-10-01 | 张家港保税区冠祥贸易有限公司 | Tourniquet |
| CN105734830A (en) * | 2016-04-05 | 2016-07-06 | 东华大学 | Method for preparing composite nanofiber felt of houttuynia cordata essential oil and chitosan |
| CN105970482A (en) * | 2014-11-07 | 2016-09-28 | 蔡留凤 | Biomedical electrostatic spinning membrane based on medical polymer material and preparation method of membrane |
| CN106172734A (en) * | 2016-07-27 | 2016-12-07 | 四川农业大学 | A kind of strawberry preservation composite package film and preparation method thereof |
| CN107620132A (en) * | 2016-07-13 | 2018-01-23 | 天津市职业大学 | Emulsion electrostatic spinning core shell structure antibacterial nanofiber membrane and preparation method thereof |
| CN108114307A (en) * | 2018-02-07 | 2018-06-05 | 苏州元禾医疗器械有限公司 | The preparation method of the medical dressing of high-biocompatibility |
| CN108159474A (en) * | 2018-02-07 | 2018-06-15 | 苏州元禾医疗器械有限公司 | A kind of preparation method for the dressing for being suitable for burn |
| CN108187123A (en) * | 2018-02-07 | 2018-06-22 | 苏州元禾医疗器械有限公司 | A kind of absorbable hemostasia dressing |
| CN108210977A (en) * | 2018-02-07 | 2018-06-29 | 苏州元禾医疗器械有限公司 | The absorption styptic dressing of high imbibition ability |
| CN109868525A (en) * | 2019-02-19 | 2019-06-11 | 青岛海赛尔新材料科技有限公司 | A kind of preparation method of high intensity seaweed and polyvinyl alcohol blending fiber |
| CN111557790A (en) * | 2020-05-16 | 2020-08-21 | 江苏德鲁克生物科技有限公司 | Antibacterial and disinfectant nanofiber medical dressing |
| CN113041031A (en) * | 2021-03-03 | 2021-06-29 | 山东恒鹏卫生用品有限公司 | Spun-bonded antibacterial non-woven fabric front waist tape for diaper and preparation method thereof |
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| CN103800939A (en) * | 2014-02-14 | 2014-05-21 | 武汉烺祺生物科技有限公司 | Antibacterial healing-functional dressing and preparation method thereof |
| CN103800939B (en) * | 2014-02-14 | 2015-09-02 | 武汉烺祺生物科技有限公司 | A kind of antibacterial healing functional dressing and preparation method thereof |
| CN104013450A (en) * | 2014-06-12 | 2014-09-03 | 张家港保税区冠祥贸易有限公司 | Tourniquet bandage |
| CN104069534A (en) * | 2014-06-12 | 2014-10-01 | 张家港保税区冠祥贸易有限公司 | Tourniquet |
| CN105970482A (en) * | 2014-11-07 | 2016-09-28 | 蔡留凤 | Biomedical electrostatic spinning membrane based on medical polymer material and preparation method of membrane |
| CN105734830A (en) * | 2016-04-05 | 2016-07-06 | 东华大学 | Method for preparing composite nanofiber felt of houttuynia cordata essential oil and chitosan |
| CN107620132A (en) * | 2016-07-13 | 2018-01-23 | 天津市职业大学 | Emulsion electrostatic spinning core shell structure antibacterial nanofiber membrane and preparation method thereof |
| CN106172734A (en) * | 2016-07-27 | 2016-12-07 | 四川农业大学 | A kind of strawberry preservation composite package film and preparation method thereof |
| CN108114307A (en) * | 2018-02-07 | 2018-06-05 | 苏州元禾医疗器械有限公司 | The preparation method of the medical dressing of high-biocompatibility |
| CN108159474A (en) * | 2018-02-07 | 2018-06-15 | 苏州元禾医疗器械有限公司 | A kind of preparation method for the dressing for being suitable for burn |
| CN108187123A (en) * | 2018-02-07 | 2018-06-22 | 苏州元禾医疗器械有限公司 | A kind of absorbable hemostasia dressing |
| CN108210977A (en) * | 2018-02-07 | 2018-06-29 | 苏州元禾医疗器械有限公司 | The absorption styptic dressing of high imbibition ability |
| CN109868525A (en) * | 2019-02-19 | 2019-06-11 | 青岛海赛尔新材料科技有限公司 | A kind of preparation method of high intensity seaweed and polyvinyl alcohol blending fiber |
| CN111557790A (en) * | 2020-05-16 | 2020-08-21 | 江苏德鲁克生物科技有限公司 | Antibacterial and disinfectant nanofiber medical dressing |
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| CN116763974A (en) * | 2023-07-11 | 2023-09-19 | 山东哈工生物科技有限公司 | Medical biodegradable application and preparation method thereof |
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