CN103518770A - Bactericidal composition containing fluopyram and triazole - Google Patents
Bactericidal composition containing fluopyram and triazole Download PDFInfo
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- CN103518770A CN103518770A CN201210229693.2A CN201210229693A CN103518770A CN 103518770 A CN103518770 A CN 103518770A CN 201210229693 A CN201210229693 A CN 201210229693A CN 103518770 A CN103518770 A CN 103518770A
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- Prior art keywords
- acid amides
- pyrrole bacterium
- bacterium acid
- fluorine pyrrole
- active component
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- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 21
- 150000003852 triazoles Chemical class 0.000 title claims abstract description 19
- 239000005783 Fluopyram Substances 0.000 title claims abstract description 14
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 34
- 201000010099 disease Diseases 0.000 claims abstract description 33
- ZMYFCFLJBGAQRS-IRXDYDNUSA-N (2R,3S)-epoxiconazole Chemical compound C1=CC(F)=CC=C1[C@@]1(CN2N=CN=C2)[C@H](C=2C(=CC=CC=2)Cl)O1 ZMYFCFLJBGAQRS-IRXDYDNUSA-N 0.000 claims abstract description 20
- LQDARGUHUSPFNL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(COC(F)(F)C(F)F)CN1C=NC=N1 LQDARGUHUSPFNL-UHFFFAOYSA-N 0.000 claims abstract description 20
- WKBPZYKAUNRMKP-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(CCC)CN1C=NC=N1 WKBPZYKAUNRMKP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000005767 Epoxiconazole Substances 0.000 claims abstract description 20
- 239000005813 Penconazole Substances 0.000 claims abstract description 20
- 239000005840 Tetraconazole Substances 0.000 claims abstract description 20
- FQKUGOMFVDPBIZ-UHFFFAOYSA-N flusilazole Chemical compound C=1C=C(F)C=CC=1[Si](C=1C=CC(F)=CC=1)(C)CN1C=NC=N1 FQKUGOMFVDPBIZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- JWUCHKBSVLQQCO-UHFFFAOYSA-N 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol Chemical compound C=1C=C(F)C=CC=1C(C=1C(=CC=CC=1)F)(O)CN1C=NC=N1 JWUCHKBSVLQQCO-UHFFFAOYSA-N 0.000 claims abstract description 19
- UFNOUKDBUJZYDE-UHFFFAOYSA-N 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Chemical compound C1=NC=NN1CC(O)(C=1C=CC(Cl)=CC=1)C(C)C1CC1 UFNOUKDBUJZYDE-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000005757 Cyproconazole Substances 0.000 claims abstract description 19
- 239000005787 Flutriafol Substances 0.000 claims abstract description 19
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- 241000894006 Bacteria Species 0.000 claims description 104
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- MNHVNIJQQRJYDH-UHFFFAOYSA-N 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-1,2,4-triazole-3-thione Chemical compound N1=CNC(=S)N1CC(C1(Cl)CC1)(O)CC1=CC=CC=C1Cl MNHVNIJQQRJYDH-UHFFFAOYSA-N 0.000 abstract 1
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- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 4
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 4
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- NDDVRXSINJWQDX-UHFFFAOYSA-N 1,2,2,3,3,4-hexafluoropyrrole Chemical compound FC=1C(C(N(C=1)F)(F)F)(F)F NDDVRXSINJWQDX-UHFFFAOYSA-N 0.000 description 1
- YBNQFFSHDBUNAA-UHFFFAOYSA-N 2,3,4-trifluoro-1h-pyrrole Chemical compound FC1=CNC(F)=C1F YBNQFFSHDBUNAA-UHFFFAOYSA-N 0.000 description 1
- UXPRZZZNGFVXRR-UHFFFAOYSA-N 2,3-difluoro-1h-pyrrole Chemical compound FC=1C=CNC=1F UXPRZZZNGFVXRR-UHFFFAOYSA-N 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
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- 241000219112 Cucumis Species 0.000 description 1
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- 241000233654 Oomycetes Species 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
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- 230000001954 sterilising effect Effects 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition containing fluopyram and triazole, which contains an active component A and an active component B, wherein the active component A is selected from fluopyram; the active component B is a triazole bactericide; the triazole bactericide is selected from any one of tetraconazole, epoxiconazole, penconazole, flusilazole, flutriafol, cyproconazole and prothioconazole; and the weight ratio of the active component A to the active component B is 1:80-60:1. The composition disclosed by the invention has higher activity for multiple diseases on multiple crops, and has obvious synergistic action, thereby widening the bactericidal spectrum. The composition has the characteristics of small dosage, rainfall erosion resistance and obvious synergistic action.
Description
Technical field
The invention belongs to technical field of pesticide, the application of the bactericidal composition that relates to a kind of containing fluopyram and triazole type in crop pest.
Technical background
The chloro-5-of fluorine pyrrole bacterium acid amides (Fluopyram) chemical name: N-{2-[3-(trifluoromethyl)-2-pyridine radicals) ethyl]-α, α, the fluoro-0-toluamide of α-tri-, molecular formula: C
16h
11clF
6n
2o.It is to suppress mitochondrial respiratory by hindering the electronics transfer of succinate dehydrogenase in respiratory chain.Reach the object of controlling pathogenic bacteria by several stages of suppressing in pathogen growth cycle, be mainly used in preventing and treating on broad leaf crop the microbial disease of ascus.
The triazole bactericidal agent sterilization wide spectrum-many kinds of disease funguses of sac fungi, basidiomycetes, imperfect fungus are had to very high activity, but to oomycetes non-activity; Efficiently-drug effect is high, dosage reduces; Lasting period length-blade face 15-20 days, seed treatment is about 80 days, and soil treatment 100 days is all long than general bactericide, and extends with the increase of dosage; Interior suction transporting is good, and infiltration rate is fast, dispenser after 2 hours the absorbed amount of triazolone can suppress the growth of powdery mildew; There is strong preventive effect, therapeutic action preferably, stifling and eradicant action.The mechanism of action, for to affect sterols biosynthesis, is damaged somatic cells film function.
In the real process of agricultural production, preventing and treating the problem that disease the most easily produces is the generation of disease drug resistance.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really has the seldom composite of synergistic effect, especially synergistic effect very obviously, synergy ratio very high composite just still less.Through inventor's research, discovery is mutually composite by fluorine pyrrole bacterium acid amides and tetraconazole, epoxiconazole, penconazole, Flusilazole, Flutriafol, Cyproconazole, prothioconazoles, there is within the specific limits good synergistic effect, and relevant composite about fluorine pyrrole bacterium acid amides and tetraconazole, epoxiconazole, penconazole, Flusilazole, Flutriafol, Cyproconazole, prothioconazoles, there is not yet relevant report at present at home and abroad.
Summary of the invention
The object of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect is good containing fluopyram and the bactericidal composition of triazole type.
The present invention is achieved through the following technical solutions:
The bactericidal composition of a kind of containing fluopyram and triazole type, it is characterized in that containing active components A and active component B, active components A and active component B weight ratio are 1 ︰ 80 ~ 60 ︰ 1, described active components A is selected from fluorine pyrrole bacterium acid amides, active component B is triazole bactericidal agent, and described triazole bactericidal agent is selected from following any one compound: a kind of in tetraconazole, epoxiconazole, penconazole, Flusilazole, Flutriafol, Cyproconazole, prothioconazoles; The preferred weight ratio of active components A and active component B is 1 ︰ 60 ~ 40 ︰ 1; More preferably the weight ratio of fluorine pyrrole bacterium acid amides and tetraconazole is 1 ︰ 20 ~ 20 ︰ 1, the weight ratio of fluorine pyrrole bacterium acid amides and epoxiconazole is 1 ︰ 30 ~ 15 ︰ 1, the weight ratio of fluorine pyrrole bacterium acid amides and penconazole is 1 ︰ 15 ~ 30 ︰ 1, the weight ratio of fluorine pyrrole bacterium acid amides and Flusilazole or Flutriafol or Cyproconazole is 1 ︰ 30 ~ 20 ︰ 1, and the weight ratio of fluorine pyrrole bacterium acid amides and prothioconazoles is 1 ︰ 40 ~ 10 ︰ 1; The weight ratio that most preferably is fluorine pyrrole bacterium acid amides and tetraconazole is 1 ︰ 10 ~ 10 ︰ 1, the weight ratio of fluorine pyrrole bacterium acid amides and epoxiconazole is 1 ︰ 10 ~ 5 ︰ 1, the weight ratio of fluorine pyrrole bacterium acid amides and penconazole is 1 ︰ 5 ~ 10 ︰ 1, the weight ratio of fluorine pyrrole bacterium acid amides and Flusilazole or Flutriafol or Cyproconazole is 1 ︰ 15 ~ 10 ︰ 1, and the weight ratio of fluorine pyrrole bacterium acid amides and prothioconazoles is 1 ︰ 15 ~ 5 ︰ 1.
Described containing fluopyram and the bactericidal composition of the triazole type disease for preventing and treating crops, described crops comprise cereal crops, legume crop, fiber crop, sugar [yielding, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crop, flowers crop, medicinal crop, raw material crop, green manure pasture crop; Described disease comprises powdery mildew, smut, rust, glume blight, moire disease, banded sclerotial blight, leaf spot, spot defoliation, scab, white rot, brown spot, gray mold, leaf blight, early blight, anthrachose of grape, spot blight, black spot, anthracnose, shot hole, rust, leaf mold, fusarium wilt, stalk break, net blotch, balck shank.
The amount of application when content of active component depends on independent use in the present composition, also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with target disease.Conventionally in composition, the weight percentage of active component is gross weight 1%～90%, is preferably 5%～80%.According to different preparation types, active component content scope is different.Conventionally, liquid preparation contains 1%～60% active substance by weight, is preferably 5%～50%; Solid pharmaceutical preparation contains 5%～80% active substance by weight, is preferably 10%～80%.
In bactericidal composition of the present invention, at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 2%～30% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, thickener or defoamer.According to different dosage form, in preparation, can also contain stabilizing agent known in those skilled in the art, antifreeze etc.
Bactericidal composition of the present invention can be by user before use through dilution or directly use.Its preparation can be prepared by processing method known in those skilled in the art, after being about to active component and mixing with liquid flux or solid carrier, then adds surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, defoamer etc.
Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein preferred dosage form is wetting powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspending agent.
The invention has the advantages that: (1) present composition has good synergy and lasting effect within the specific limits, and preventive effect is higher than single dose; (2) agricultural chemicals dosage reduces, and reduces the residual quantity of agricultural chemicals on crop, alleviates environmental pollution; (3) expanded fungicidal spectrum, multiple diseases has been had to greater activity.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Example 1～22 wetting powder
Fluorine pyrrole bacterium acid amides, active component B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into wetting powder product of the present invention.Specifically in Table 1,2.
Table 1 example 1～12 each component and content
Table 2 example 13～22 each component and content
Example 23～42 water dispersible granules
Fluorine pyrrole bacterium acid amides, active component B, dispersant, wetting agent, disintegrant, filler are obtained to the particle diameter needing through air-flow crushing together, then add other auxiliary agents such as binding agent (can add and can not add), obtain the materials of granulating.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, make water dispersible granules product of the present invention.Specifically in Table 3.
Table 3 example 23～42 each component and content
Example 43～62 suspending agents
Dispersant, wetting agent, thickener (can add and can not add), defoamer, antifreeze (can add and can not add) are mixed through high speed shear, add fluorine pyrrole bacterium acid amides, active component B, by deionized water, supply surplus, in ball mill, ball milling is 2 ~ 3 hours, make diameter of particle all below 5 μ m, make suspending agent product of the present invention.Specifically in Table 4.
Table 4 example 43～62 each component and content
Example 63～79 suspension emulsions
Dispersant, defoamer, thickener (can add and can not add), antifreeze (can add and can not add), deionized water are mixed through high speed shear, add fluorine pyrrole bacterium acid amides, in ball mill, ball milling is 2 ~ 3 hours, make diameter of particle all below 5 μ m, make fluorine pyrrole bacterium acid amides suspending agent, then by tetraconazole or penconazole or Flusilazole, solvent, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make suspension emulsion product of the present invention.
Dispersant, defoamer, thickener (can add and can not add), antifreeze (can add and can not add), deionized water are mixed through high speed shear, add epoxiconazole or Flutriafol or Cyproconazole or prothioconazoles, in ball mill, ball milling is 2 ~ 3 hours, make diameter of particle all below 5 μ m, make corresponding suspending agent, then by fluorine pyrrole bacterium acid amides, solvent, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make suspension emulsion product of the present invention.Specifically in Table 5,6,7.
Table 5 example 63～68 each component and content
Table 6 example 69～73 each component and content
Table 7 example 74～79 each component and content
Example 80～97 aqueous emulsions
Fluorine pyrrole bacterium acid amides, active component B, solvent, emulsifier are added together, make to be dissolved into even oil phase; Deionized water, antifreeze (can add and can not add), thickener (can add and can not add), defoamer are mixed, become homogeneous water.Under high-speed stirred, water is added to oil phase, make aqueous emulsion product of the present invention.Specifically in Table 8.
Table 8 example 80～97 each component and content
Table 1 to tetraconazole, epoxiconazole, penconazole, Flusilazole, Flutriafol, Cyproconazole, prothioconazoles in table 8 exchanged, can make novel formulation.
Example 98～100 microemulsions
Fluorine pyrrole bacterium acid amides, active component B are dissolved in the homogenizer that solvent is housed, emulsifier, antifreeze (can add and can not add), defoamer are joined in the homogenizer that above-mentioned solution is housed, after supplying surplus by deionized water, give strong mixing and homogenize, finally obtain the as clear as crystal microemulsion product of the present invention of outward appearance.Specifically in Table 9.
Table 9 example 98～100 each component and content
Example 101～103 microcapsule suspending agents
By fluorine pyrrole bacterium acid amides, active component B, macromolecule cyst material, solvent, make to be dissolved into even oil phase, under shearing condition, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent, dispersant, defoamer, by deionized water, supply surplus, bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the finely disseminated microcapsule suspending agent product of the present composition.Specifically in Table 10.
Table 10 example 101～103 each component and content
Example 94～96 microcapsule suspensions-suspending agent
By tetraconazole or penconazole or Flusilazole, macromolecule cyst material, solvent, make to be dissolved into even oil phase, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent under shearing condition, make finely disseminated microcapsule suspending agent.Dispersant, wetting agent, defoamer, thickener (can add and can not add) are mixed through high speed shear, add fluorine pyrrole bacterium acid amides, in ball mill, ball milling is 2 ~ 3 hours, make diameter of particle all below 5 μ m, make suspending agent, then suspending agent is joined in the aqueous phase solution of micro-capsule suspension, deionized water is supplied surplus, makes the finely disseminated microcapsule suspension-suspending agent of present composition product.
By fluorine pyrrole bacterium acid amides, macromolecule cyst material, solvent, make to be dissolved into even oil phase, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent under shearing condition, make finely disseminated microcapsule suspending agent.Dispersant, wetting agent, defoamer, thickener (can add and can not add) are mixed through high speed shear, add epoxiconazole or Flutriafol or Cyproconazole or prothioconazoles, in ball mill, ball milling is 2 ~ 3 hours, make diameter of particle all below 5 μ m, make suspending agent, then suspending agent is joined in the aqueous phase solution of micro-capsule suspension, deionized water is supplied surplus, makes the finely disseminated microcapsule suspension-suspending agent of present composition product.Specifically in Table 11.
Table 11 example 104～106 each component and content
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carries out field trial.
Test method: after the effective inhibition concentration scope of each medicament is determined in prerun, medicament is established respectively 5 dosage by active constituent content and processed, and establishes clear water contrast.With reference to " farm-chemical indoor determination test rule bactericide ", carry out, adopt mycelial growth rate method to measure the virulence of medicament to crop germ.After 72h, by right-angled intersection method, measure colony diameter, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value to (x), with method of least squares, tries to achieve virulence regression equation (y=a+bx), and calculates thus the EC of every kind of medicament
50value.According to Wadley method, calculate the different proportioning synergy ratio (SR) of two medicaments, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active components A and active component B shared ratio in combination; A is fluorine pyrrole bacterium acid amides; B selects a kind of in tetraconazole, epoxiconazole, penconazole, Flusilazole, Flutriafol, Cyproconazole, prothioconazoles.
Application Example two:
For trying disease: powdery mildew of cucumber; Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd; Experimental scheme: effective inhibition concentration scope of determining fluorine pyrrole bacterium acid amides and the former medicine of tetraconazole and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to powdery mildew of cucumber of table 12 fluorine pyrrole bacterium acid amides and tetraconazole
As shown in Table 12, the composite proportioning of preventing and treating powdery mildew of cucumber of fluorine pyrrole bacterium acid amides and tetraconazole is when 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both are mixed and all show synergistic effect in 1 ︰ 80 ~ 60 ︰ 1 scopes, when the proportioning of fluorine pyrrole bacterium acid amides and tetraconazole is during at 1 ︰ 20 ~ 20 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.35.The optimum ratio of finding fluorine pyrrole bacterium acid amides and tetraconazole through test is 20:1,15:1,10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:15,1:20, especially when fluorine pyrrole bacterium acid amides and tetraconazole weight ratio are 1:1, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example three:
For trying disease: sigatoka; Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd; Experimental scheme: effective inhibition concentration scope of determining fluorine pyrrole bacterium acid amides and epoxiconazole raw drug and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to sigatoka of table 13 fluorine pyrrole bacterium acid amides and epoxiconazole
As shown in Table 13, the composite proportioning of preventing and treating sigatoka of fluorine pyrrole bacterium acid amides and epoxiconazole is when 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both are mixed and all show synergistic effect in 1 ︰ 80 ~ 60 ︰ 1 scopes, when the proportioning of fluorine pyrrole bacterium acid amides and epoxiconazole is during at 1 ︰ 30 ~ 15 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.25.The optimum ratio of finding fluorine pyrrole bacterium acid amides and epoxiconazole through test is 15:1,10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:15,1:20,1:25,1:30, especially when fluorine pyrrole bacterium acid amides and epoxiconazole weight ratio are 1:2, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example four:
For trying disease: grape powdery mildew; Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd; Experimental scheme: effective inhibition concentration scope of determining fluorine pyrrole bacterium acid amides and the former medicine of penconazole and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to grape powdery mildew of table 14 fluorine pyrrole bacterium acid amides and penconazole
As shown in Table 14, the proportioning of fluorine pyrrole bacterium acid amides and the composite control grape powdery mildew of penconazole is when 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both are mixed and all show synergistic effect in 1 ︰ 80 ~ 60 ︰ 1 scopes, when the proportioning of fluorine pyrrole bacterium acid amides and penconazole is during at 1 ︰ 15 ~ 30 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.20.The optimum ratio of finding fluorine pyrrole bacterium acid amides and penconazole through test is 30:1,25:1,20:1,15:1,10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:15, especially when fluorine pyrrole bacterium acid amides and penconazole weight ratio are 2:1, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example five:
For trying disease: pear scab; Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd; Experimental scheme: effective inhibition concentration scope of determining fluorine pyrrole bacterium acid amides and flusilazole and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to pear scab of table 15 fluorine pyrrole bacterium acid amides and Flusilazole
As shown in Table 15, the proportioning of fluorine pyrrole bacterium acid amides and the composite control pear scab of Flusilazole is when 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both are mixed and all show synergistic effect in 1 ︰ 80 ~ 60 ︰ 1 scopes, when the proportioning of fluorine pyrrole bacterium acid amides and Flusilazole is during at 1 ︰ 30 ~ 20 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.20.The optimum ratio of finding fluorine pyrrole bacterium acid amides and Flusilazole through test is 20:1,15:1,10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1,2:3,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:15,1:20,1:25,1:30, especially when fluorine pyrrole bacterium acid amides and Flusilazole weight ratio are 2:3, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example six:
For trying disease: wheat powdery mildew; Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd; Experimental scheme: effective inhibition concentration scope of determining fluorine pyrrole bacterium acid amides and the former medicine of Flutriafol and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to wheat powdery mildew of table 16 fluorine pyrrole bacterium acid amides and Flutriafol
As shown in Table 16, the proportioning of fluorine pyrrole bacterium acid amides and the composite control wheat powdery mildew of Flutriafol is when 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both are mixed and all show synergistic effect in 1 ︰ 80 ~ 60 ︰ 1 scopes, when the proportioning of fluorine pyrrole bacterium acid amides and Flutriafol is during at 1 ︰ 30 ~ 20 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.20.Especially when fluorine pyrrole bacterium acid amides and Flutriafol weight ratio are 2:3, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example seven:
For trying disease: wheat rust; Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd; Experimental scheme: effective inhibition concentration scope of determining fluorine pyrrole bacterium acid amides and the former medicine of Cyproconazole and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to wheat rust of table 17 fluorine pyrrole bacterium acid amides and Cyproconazole
As shown in Table 17, the composite proportioning of preventing and treating wheat rust of fluorine pyrrole bacterium acid amides and Cyproconazole is when 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both are mixed and all show synergistic effect in 1 ︰ 80 ~ 60 ︰ 1 scopes, when the proportioning of fluorine pyrrole bacterium acid amides and Cyproconazole is during at 1 ︰ 30 ~ 20 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.30.Especially when fluorine pyrrole bacterium acid amides and Cyproconazole weight ratio are 2:3, synergy ratio is maximum, and synergistic effect is the most obvious.
Application Example eight:
For trying disease: wheat leaf blight; Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd; Experimental scheme: effective inhibition concentration scope of determining fluorine pyrrole bacterium acid amides and the former medicine of prothioconazoles and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to wheat leaf blight of table 18 fluorine pyrrole bacterium acid amides and prothioconazoles
As shown in Table 18, the proportioning of fluorine pyrrole bacterium acid amides and the composite control wheat leaf blight of prothioconazoles is when 1 ︰ 80 ~ 60 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both are mixed and all show synergistic effect in 1 ︰ 80 ~ 60 ︰ 1 scopes, when the proportioning of fluorine pyrrole bacterium acid amides and prothioconazoles is during at 1 ︰ 40 ~ 10 ︰ 1, synergistic effect is more outstanding, and synergy ratio is all greater than 2.30.Especially when fluorine pyrrole bacterium acid amides and prothioconazoles weight ratio are 1:4, synergy ratio is maximum, and synergistic effect is the most obvious.
Through test, find: after fluorine pyrrole bacterium acid amides and active component B are composite, the control of powdery mildew, smut, rust, glume blight, moire disease, banded sclerotial blight, leaf spot, spot defoliation, scab, white rot, brown spot, gray mold, leaf blight, early blight, anthrachose of grape, spot blight, black spot, anthracnose, shot hole, rust, leaf mold, fusarium wilt, stalk break, net blotch, balck shank is had to obvious synergistic effect, synergy ratio is all more than 1.50.
Test of pesticide effectiveness part
Test medicine is researched and developed, is provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd.Contrast medicament: 30% fluorine pyrrole bacterium acid amides suspending agent (autogamy), 4% tetraconazole aqueous emulsion (commercial), 12.5% epoxiconazole suspension concentrate (commercial), 10% penconazole missible oil (autogamy), 10% Flusilazole aqueous emulsion (commercial), 12.5% Flutriafol suspending agent (autogamy), 10% Cyproconazole wetting powder (autogamy), 5% prothioconazoles suspending agent (autogamy).
Application Example nine fluorine pyrrole bacterium acid amides and active component B and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
This test arrangement, in Jingyang County, Shaanxi Province, is investigated the powdery mildew of cucumber state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after last dispenser 10 days, 30 days, 45 days, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 19 fluorine pyrrole bacterium acid amides and active component B and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 19, after fluorine pyrrole bacterium acid amides and active component B are composite, can effectively prevent and treat powdery mildew of cucumber, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten fluorine pyrrole bacterium acid amides and active component B and the composite sigatoka test of pesticide effectiveness of preventing and treating thereof
This test arrangement, in Nanning, is investigated the sigatoka state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after last dispenser 10 days, 30 days, 45 days, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 20 fluorine pyrrole bacterium acid amides and active component B and the composite sigatoka test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 20, after fluorine pyrrole bacterium acid amides and active component B are composite, can effectively prevent and treat sigatoka, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 11 fluorine pyrrole bacterium acid amides and active component B and the composite control pear scab test of pesticide effectiveness thereof
This test arrangement, in Xianyang, Shanxi province city, is investigated the pear scab state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after last dispenser 10 days, 30 days, 60 days, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 21 fluorine pyrrole bacterium acid amides and active component B and the composite control pear scab test of pesticide effectiveness thereof
As can be seen from Table 21, after fluorine pyrrole bacterium acid amides and active component B are composite, can effectively prevent and treat pear scab, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten difluoro pyrrole bacterium acid amides and active component B and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
This test arrangement, in Xianyang, Shanxi province city, is investigated the alternaria leaf spot of apple state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after last dispenser 10 days, 30 days, 45 days, investigate respectively disease index and calculate preventive effect.Experimental result is as follows: table 22 fluorine pyrrole bacterium acid amides and active component B and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
As can be seen from Table 22, after fluorine pyrrole bacterium acid amides and active component B are composite, can effectively prevent and treat alternaria leaf spot of apple, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten trifluoro pyrrole bacterium acid amides and active component B and the composite control wheat powdery mildew test of pesticide effectiveness thereof
This test arrangement, at Shaanxi Province's Weinan City, is investigated the wheat powdery mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after last dispenser 10 days, 20 days, 30 days, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 23 fluorine pyrrole bacterium acid amides and active component B and the composite control wheat powdery mildew test of pesticide effectiveness thereof
As can be seen from Table 23, after fluorine pyrrole bacterium acid amides and active component B are composite, can effectively prevent and treat wheat powdery mildew, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten tetrafluoro pyrrole bacterium acid amides and active component B and the composite control flowers powdery mildew test of pesticide effectiveness thereof
This test arrangement, in Changan District, Xi'an City, Shanxi Province, is investigated the flowers powdery mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after last dispenser 10 days, 30 days, 45 days, investigate respectively disease index and calculate preventive effect.Experimental result is as follows: table 24 fluorine pyrrole bacterium acid amides and active component B and the composite control flowers powdery mildew test of pesticide effectiveness thereof
As can be seen from Table 24, after fluorine pyrrole bacterium acid amides and active component B are composite, can effectively prevent and treat flowers powdery mildew, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 15 fluorine pyrrole bacterium acid amides and active component B and the composite wheat rust test of pesticide effectiveness of preventing and treating thereof
This test arrangement, at Shaanxi Province's Weinan City, is investigated the wheat rust state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after last dispenser 10 days, 20 days, 30 days, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 25 fluorine pyrrole bacterium acid amides and active component B and the composite wheat rust test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 25, after fluorine pyrrole bacterium acid amides and active component B are composite, can effectively prevent and treat wheat rust, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten hexafluoro pyrrole bacterium acid amides and active component B and the composite control watermelon anthrax test of pesticide effectiveness thereof
This test arrangement, in Weinan City Dali County, Shaanxi Province, is investigated the watermelon anthrax state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after last dispenser 10 days, 30 days, 45 days, investigate respectively disease index and calculate preventive effect.Experimental result is as follows: table 26 fluorine pyrrole bacterium acid amides and active component B and the composite control watermelon anthrax test of pesticide effectiveness thereof
As can be seen from Table 26, after fluorine pyrrole bacterium acid amides and active component B are composite, can effectively prevent and treat watermelon anthrax, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 17 fluorine pyrrole bacterium acid amides and active component B and the composite cladosporium leaf and fruit mould of tomato test of pesticide effectiveness of preventing and treating thereof
This test arrangement, at Xian District, Shanxi Province suburban area, is investigated the cladosporium leaf and fruit mould of tomato state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after last dispenser 10 days, 30 days, 60 days, investigate respectively disease index and calculate preventive effect.Experimental result is as follows: table 27 fluorine pyrrole bacterium acid amides and active component B and the composite cladosporium leaf and fruit mould of tomato test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 27, after fluorine pyrrole bacterium acid amides and active component B are composite, can effectively prevent and treat cladosporium leaf and fruit mould of tomato, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten octafluoro pyrrole bacterium acid amides and active component B and the composite control grape powdery mildew test of pesticide effectiveness thereof
This test arrangement, in Weinan City suburb, Shaanxi Province, is investigated the grape powdery mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, once, dispenser is 2 times altogether in dispenser in every 7 days.Within after last dispenser 10 days, 30 days, 45 days, investigate respectively disease index and calculate preventive effect.Experimental result is as follows: table 28 fluorine pyrrole bacterium acid amides and active component B and the composite control grape powdery mildew test of pesticide effectiveness thereof
As can be seen from Table 28, after fluorine pyrrole bacterium acid amides and active component B are composite, can effectively prevent and treat grape powdery mildew, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
After through different local throughout the country tests, draw, fluorine pyrrole bacterium acid amides and tetraconazole, epoxiconazole, penconazole, Flusilazole, Flutriafol, Cyproconazole, prothioconazoles is composite rear to the powdery mildew in various crop, smut, rust, glume blight, moire disease, banded sclerotial blight, leaf spot, spot defoliation, scab, white rot, brown spot, gray mold, leaf blight, early blight, anthrachose of grape, spot blight, black spot, anthracnose, shot hole, rust, leaf mold, fusarium wilt, stalk break, net blotch, the preventive effect of the Common Diseases such as balck shank is all more than 95%, be better than single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. the bactericidal composition of a containing fluopyram and triazole type, it is characterized in that containing active components A and active component B, active components A and active component B weight ratio are 1 ︰ 80 ~ 60 ︰ 1, described active components A is selected from fluorine pyrrole bacterium acid amides, active component B is triazole bactericidal agent, and described triazole bactericidal agent is selected from following any one compound: a kind of in tetraconazole, epoxiconazole, penconazole, Flusilazole, Flutriafol, Cyproconazole, prothioconazoles.
2. the bactericidal composition of containing fluopyram according to claim 1 and triazole type, is characterized in that: the weight ratio of active components A and active component B is 1 ︰ 60 ~ 40 ︰ 1.
3. the bactericidal composition of containing fluopyram according to claim 2 and triazole type, is characterized in that:
The weight ratio of fluorine pyrrole bacterium acid amides and tetraconazole is 1 ︰ 20 ~ 20 ︰ 1;
The weight ratio of fluorine pyrrole bacterium acid amides and epoxiconazole is 1 ︰ 30 ~ 15 ︰ 1;
The weight ratio of fluorine pyrrole bacterium acid amides and penconazole is 1 ︰ 15 ~ 30 ︰ 1;
The weight ratio of fluorine pyrrole bacterium acid amides and Flusilazole or Flutriafol or Cyproconazole is 1 ︰ 30 ~ 20 ︰ 1;
The weight ratio of fluorine pyrrole bacterium acid amides and prothioconazoles is 1 ︰ 40 ~ 10 ︰ 1.
4. according to the bactericidal composition of the containing fluopyram described in any one in claim 1 ~ 3 and triazole type, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspending agent.
5. the bactericidal composition of containing fluopyram according to claim 4 and triazole type is for preventing and treating the application of corps diseases.
6. application according to claim 5, is characterized in that: described disease comprises powdery mildew, smut, rust, glume blight, moire disease, banded sclerotial blight, leaf spot, spot defoliation, scab, white rot, brown spot, gray mold, leaf blight, early blight, anthrachose of grape, spot blight, black spot, anthracnose, shot hole, rust, leaf mold, fusarium wilt, stalk break, net blotch, balck shank.
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| CN104872141A (en) * | 2015-05-25 | 2015-09-02 | 广东中迅农科股份有限公司 | Sterilization composition containing triticonazole and fluopyram |
| CN105265438A (en) * | 2014-05-27 | 2016-01-27 | 深圳诺普信农化股份有限公司 | Bactericidal composition |
| CN109068649A (en) * | 2016-04-24 | 2018-12-21 | 拜耳农作物科学股份公司 | Fluopyram and/or bacillus subtilis are used to prevent and treat the purposes of the wilt disease of Musaceae plant |
| US10827754B2 (en) | 2004-02-12 | 2020-11-10 | Bayer Cropscience Aktiengesellschaft | Fungicidal composition comprising a pyridylethylbenzamide derivative and a compound capable of inhibiting the ergosterol biosynthesis |
| WO2020231751A1 (en) * | 2019-05-10 | 2020-11-19 | Bayer Cropscience Lp | Active compound combinations |
| CN113287623A (en) * | 2021-05-25 | 2021-08-24 | 贵州道元生物技术有限公司 | Compound bactericide for preventing and treating tobacco root knot nematode disease |
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| WO2010000612A1 (en) * | 2008-07-01 | 2010-01-07 | Syngenta Participations Ag | Fungicidal compositions |
| WO2010108507A2 (en) * | 2009-03-25 | 2010-09-30 | Bayer Cropscience Ag | Synergistic combinations of active ingredients |
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| WO2010000612A1 (en) * | 2008-07-01 | 2010-01-07 | Syngenta Participations Ag | Fungicidal compositions |
| WO2010108507A2 (en) * | 2009-03-25 | 2010-09-30 | Bayer Cropscience Ag | Synergistic combinations of active ingredients |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10827754B2 (en) | 2004-02-12 | 2020-11-10 | Bayer Cropscience Aktiengesellschaft | Fungicidal composition comprising a pyridylethylbenzamide derivative and a compound capable of inhibiting the ergosterol biosynthesis |
| CN105265438A (en) * | 2014-05-27 | 2016-01-27 | 深圳诺普信农化股份有限公司 | Bactericidal composition |
| CN104872141A (en) * | 2015-05-25 | 2015-09-02 | 广东中迅农科股份有限公司 | Sterilization composition containing triticonazole and fluopyram |
| CN109068649A (en) * | 2016-04-24 | 2018-12-21 | 拜耳农作物科学股份公司 | Fluopyram and/or bacillus subtilis are used to prevent and treat the purposes of the wilt disease of Musaceae plant |
| WO2020231751A1 (en) * | 2019-05-10 | 2020-11-19 | Bayer Cropscience Lp | Active compound combinations |
| CN113287623A (en) * | 2021-05-25 | 2021-08-24 | 贵州道元生物技术有限公司 | Compound bactericide for preventing and treating tobacco root knot nematode disease |
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Address after: 715500 Pucheng high tech Industrial Development Zone, Weinan, Shaanxi Patentee after: SHAANXI MEIBANG PHARMACEUTICAL GROUP Co.,Ltd. Address before: 715500 Shaanxi Pucheng Weinan County agricultural base industrial park Patentee before: Shaanxi Meibang pesticide Co.,Ltd. |
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Commission number: 4W115745 Conclusion of examination: On the basis of claims 1-3 submitted by the patentee on October 20, 2023, the invention patent number 201210229693.2 is maintained as valid Decision date of declaring invalidation: 20231106 Decision number of declaring invalidation: 564691 Denomination of invention: A bactericidal combination containing fluoropyrazole amide and triazole Granted publication date: 20141224 Patentee: SHAANXI MEIBANG PHARMACEUTICAL GROUP Co.,Ltd. |
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