CN103495174A - Multi-effect external preparation used for treating superficial skin injury and application thereof - Google Patents
Multi-effect external preparation used for treating superficial skin injury and application thereof Download PDFInfo
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Abstract
The invention provides a multi-effect external preparation used for treating superficial skin injury and an application thereof. The multi-effect external preparation used for treating the superficial skin injury comprises the following components in mass fraction: 1-20% of coagulant, 0.2-10% of pain-easing medicine, 0.2-20% of healing accelerant, 0.005-10% of antibacterial material and 40-90% of pharmaceutical adjuvant. The multi-effect external preparation has multiple effects of stopping bleeding, easing pain, accelerating healing and fighting infection and can enhance treatment effect on superficial skin injury.
Description
Technical field
The invention belongs to medical technical field, hemostasis while being specifically related to for the shallow skin injury, analgesia, promoting healing, anti-infective multi-effect external formulation art.
Background technology
Hemostasis is the important step in trauma care and treatment, for patient's recovery and daily routines, important impact is arranged.Multiple hemostasis is arranged in the treatment of wound, as the application of compression hemostasis, perstriction, electric coagulation hemostasis method, blood vessel blocking method, vascular repair method and haemostatic medicament.In skin injury; usually use blood coagulation substance to be stopped blooding; clinical hemostatic substance commonly used or medicine comprise cattle or restructuring thrombin, plasma coagulation factors F II, VII, IX, X, tranexamic acid, protamine, remove amine vassopressin, aminocaproic acid etc. at present; the effect characteristics of these blood coagulation substances are that mechanism of action is clear and definite; can act on the links of coagulation process; the blood coagulation effect is powerful, can under low concentration, produce very strong blood coagulation effect.
Local anesthetic is as lignocaine, tetracaine, prilocaine, bupivacaine, levobupivacaine, ropivacaine, benzocaine, external has analgesia, itching-relieving action, these local anesthetic Transdermal absorption are good, can be applicable to clinically minor burn and the shallowⅱ°burn of small size.
The antibacterial action of nano level metal-oxide and metal simple-substance is paid close attention to more and more widely, and these inorganic material have the antibacterial ability of wide spectrum, and various antibacterials, mycete, yeast are had to effect; Inorganic material can Fast Stripping, volatilization, therefore has the effect of long acting antibiotic; A lot of metallic elements are all needed by human body in addition, and life-time service is little than antibiotic to the toxic and side effects of human body.The external preparation such as nanometer silver are life-time service clinically, and its safety and effectiveness are confirmed.
The shallow skin injury is damage common in daily life such as abrade, damage, shallowⅱ°burn etc., usually can cause the problems such as hemorrhage, pain, healing difficulty, infection.In the shallow skin injury, because teleneuron is exposed under stimulation, wound surface can produce and have an intense pain, and wound surface is hemorrhage as processed and also make troubles for patient's daily routines not in time in addition.External used medicine such as the silver sulfadiazine for the treatment of shallow skin injury, povidone iodine ointment, YUNNAN BAIYAO etc. are the preparation of single effect (infection or pain relieving) at present, are difficult to meet Treatment need.Therefore very an urgent demand is developed a class and is had the external preparation of hemostasis, analgesia, promoting healing, infection multi-efficiency concurrently to improve the treatment rate of trauma patient.
Summary of the invention
The object of the present invention is to provide a kind of multi-effect external preparation that is used for the treatment of the shallow skin injury and uses thereof, this external preparation has hemostasis, analgesia, promoting healing, the effect of anti-infective multiple-effect.
For achieving the above object, the present invention has adopted following technical scheme:
A kind of multi-effect external preparation that is used for the treatment of the shallow skin injury, this external preparation is comprised of the coagulation matters of 1-20%, the analgesic of 0.2-10%, the promoting healing thing of 0.2-20%, the anti-biotic material of 0.005-10% and the pharmaceutic adjuvant of 40-90% by mass fraction.
Described coagulation matters is one or both in thrombin or Fibrinogen, described analgesic is local anesthetic, described promoting healing thing is one or both in heparin sodium or allantoin, and described anti-biotic material is one or more in nano metal or nano-metal-oxide.
Described thrombin is through the Polyethylene Glycol covalent modification, and Fibrinogen is through the Polyethylene Glycol covalent modification.
Described analgesic is one or more in lignocaine, tetracaine, prilocaine, bupivacaine, levobupivacaine, ropivacaine or benzocaine.
Described anti-biotic material is nanometer silver, nano zine oxide, one or more in nano magnesia or nano calcium oxide, and described nanometer silver, nano zine oxide, the particle diameter of nano magnesia or nano calcium oxide is 1-100nm.
Described preparation is ointment, membrane, powder, Emulsion, solution or gel.
The preparation method of described gel is:
1. carbomer is added in ultra-pure water and carry out the nature swelling and obtain transparent colloid, in transparent colloid, add glycerol, colloidal sol then stirs to obtain; 2. analgesic is joined in described colloidal sol, then with triethanolamine, regulate pH to 6-8; 3. through step 2. after, coagulation matters, promoting healing thing and anti-biotic material are joined in described colloidal sol, add again ultra-pure water after being uniformly mixed and obtain mixture, by mixture stir rear degassed, sterilizing, embedding, packing.
Described external preparation is comprised of the thrombin through the Polyethylene Glycol covalent modification of 2-10%, the Fibrinogen through the Polyethylene Glycol covalent modification of 2-10%, local anesthetic, 0.013-0.067% heparin sodium, the allantoin of 0.5-2%, the nano metal of 0.01-2% or the pharmaceutic adjuvant of nano-metal-oxide and 70-90% of 0.2-2% by mass fraction.
Described local anesthetic is lignocaine, tetracaine, prilocaine or benzocaine, and described nano metal is nanometer silver, and described nano-metal-oxide is nano zine oxide, nano magnesia or nano calcium oxide.
The above-mentioned purposes of multi-effect external preparation in preparation treatment shallow skin injury medicine that is used for the treatment of the shallow skin injury.
Beneficial effect of the present invention is embodied in:
External preparation of the present invention is for the related link of the genesis of the shallow skin injurys such as burns, scald, trauma, effective prevent and avoid traumatic infection, analgesic activity is strong and lasting, antiinflammatory action is strong, and the effective wound healing of energy, having chosen the clinical active ingredient used in the prescription of external preparation of the present invention is combined, with compound Chinese medicinal preparation, to compare drug effect clearer and more definite, safety is better, and the drug regimen of external preparation of the present invention has synergism aspect promoting healing and infection.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described.
A kind of hemostasis during for the shallow skin injury, analgesia, promoting healing, anti-infective multi-effect external preparation, comprise medically acceptable coagulation matters, analgesic, promoting healing thing, infection material and pharmaceutic adjuvant.Above-mentioned pharmaceutic adjuvant comprises the carrier of pharmaceutical field routine, in preparation, can contain carbomer, glycerol, triethanolamine, PEG400 etc.
Embodiment 1 multi-effect external preparation (gel) prescription and preparation (in 100g)
Prescription: lignocaine 0.5g; Nanometer silver 35mg; Polyethyleneglycol modified thrombin of beef 5g; Polyethyleneglycol modified Fibrinogen 5g; Heparin sodium 5000U(tires as 150U in every 1mg); Allantoin 1g; Carbomer-940 1g; Glycerol 20mL; Triethanolamine 1.5mL; The ultra-pure water surplus.
Preparation technology:
1) get the recipe quantity Carbomer-940 and add in ultra-pure water after in 4 ± 2 ℃ of natural swellings (> 12h), make transparent colloid, add recipe quantity glycerol in transparent colloid, the colloidal sol that stirs to obtain, standby.
2) get the recipe quantity lignocaine and dissolve in ultra-pure water, then slowly join in above-mentioned colloidal sol, and dropwise add triethanolamine to regulate pH to 6-8.
3) through step 2) after, the coagulation matters of recipe quantity (polyethyleneglycol modified Fibrinogen and polyethyleneglycol modified thrombin of beef), promoting healing thing (heparin sodium and allantoin) and nanometer silver are dissolved respectively, then slowly join in colloidal sol, stirring makes it mix homogeneously, add ultra-pure water to 100g, rear degassed, cobalt-60 radiation sterilization that stirs, then embedding, packing, obtain.
Wherein, as follows through polyethyleneglycol modified thrombin of beef and fibrinogenic synthetic method:
Use mono methoxy polyethylene glycol (the Monomethoxypolyethylene glycol of activation, mPEG) thrombin of beef, Fibrinogen are carried out to covalent modification, concrete reaction condition is as follows: in the Tris-HCl of 0.05mM buffer (PH=7.8), hatched, the molecular proportion of mPEG and thrombin of beef is 6:1; MPEG and fibrinogenic molecule ratio are 7:1.With reference to [Zhou Jiangang, Tan Yuanyou. chemical modification and the effect analysis thereof of Polyethylene Glycol to pig thrombiase. hubei agricultural science [J], 2009,48 (6): 1432-1435].The reason of being modified is that protein is unstable, directly uses easily degraded, after modifying, makes its stability increase.
Embodiment 2 multi-effect external preparation (gel) prescription and preparations (in 100g)
Prescription: tetracaine 0.6g; Nanometer silver 35mg; Polyethyleneglycol modified thrombin of beef 5g; Polyethyleneglycol modified Fibrinogen 5g; Heparin sodium 5000U(tires as 150U in every 1mg); Allantoin 1g; Carbomer-940 1g; Glycerol 20mL; Triethanolamine 1.5mL; The ultra-pure water surplus.
Preparation technology is identical with embodiment 1.
Embodiment 3 multi-effect external preparation (gel) prescription and preparations (in 100g)
Prescription: prilocaine 0.5g; Nano zine oxide 100mg; Polyethyleneglycol modified pig thrombiase 5g; Polyethyleneglycol modified Fibrinogen 5g; Heparin sodium 5000U(tires as 150U in every 1mg); Allantoin 1g; Carbomer-9341g; Glycerol 20mL; Triethanolamine 1.5mL; The ultra-pure water surplus.
Preparation technology is identical with embodiment 1.
Embodiment 4 multi-effect external preparation (gel) prescription and preparations (in 100g)
Prescription: benzocaine 0.8g; Nano magnesia 100mg; Polyethyleneglycol modified pig thrombiase 5g; Polyethyleneglycol modified Fibrinogen 5g; Heparin sodium 5000U(tires as 150U in every 1mg); Allantoin 1g; Carbomer-9411g; Glycerol 20mL; Triethanolamine 1.5mL; The ultra-pure water surplus.
Preparation technology is identical with embodiment 1.
Embodiment 5 multi-effect external preparation (gel) prescription and preparations (in 100g)
Prescription: lignocaine 0.8g; Nano calcium oxide 100mg; Polyethyleneglycol modified pig thrombiase 5g; Polyethyleneglycol modified Fibrinogen 5g; Heparin sodium 5000U(tires as 150U in every 1mg); Allantoin 1g; Carbomer-9711g; Glycerol 20mL; Triethanolamine 1.5mL; The ultra-pure water surplus.
Preparation technology is identical with embodiment 1.
Pharmacodynamic experiment
1) analgesic experiment
Experiment material: 40 of SD rats, 180-220g, provided by The Fourth Military Medical University's Experimental Animal Center; Lincomycin hydrochloride and lidocaine hydrochloride gel (the bright Pharmaceutical in Shandong side); Full-automatic burning pain stimulation instrument; Prepared multi-effect external preparation in embodiment 1-5.
Experimental technique: respectively at 1,4,24 (h) after (0h) before scalding and scald, with scald position, BME-403Von Frey dolorimeter stimulation in rats vola periphery, contact 2～3s, reading when the contracting foot occurring or licking the foot reaction is machinery contracting sufficient threshold value (mechanical withdrawal threshold, MWT).Postoperative rat is positioned over laboratory rearing, before test, rat is placed in the lucite case and adapts to 15min.Threshold value respectively stimulates 3 times up and down, interval 5min, and triplicate, get its meansigma methods.Each stimulus intervals time at least is greater than 15s, and waits to stimulate the reaction that causes (as lick foot, swing one's legs etc.) to disappear fully.
Experimental result: as shown in table 1, the multi-effect external preparation can significantly improve the mechanicalness sufficient threshold value (mechanical withdrawal threshold, MWT) that contracts, and its drug effect is identical with the positive drug lincomycin hydrochloride and lidocaine hydrochloride gel.
The quick MWT of table 1 multi-effect external preparation shallowⅱ°burn rat machinery pain measures (n=5)
Annotate: with negative control group, compare
*p<0.01,
*p<0.05; Negative control is excipient.
2) burned rats infection experiment
Experiment material: 80 of SD rats, body weight 180-220g, male and female half and half, provided by The Fourth Military Medical University's Experimental Animal Center, silver sulfadiazine ointment (Guangdong Heng Jian pharmaceutical Co. Ltd), green ointment (new Asia, Shanghai pharmaceutical Co. Ltd); Pseudomonas aeruginosa reference culture ATCC27853(Xijing hospital clinical check laboratory provides); Prepared multi-effect external preparation in embodiment 1-5.
Experimental technique: back burns rat model: 24h before test, by rat being cut by hair of both sides, back of causing injury in advance, then lose hair or feathers with 8% sodium sulfide.Before causing injury, with pentobarbital sodium, anaesthetize sb. generally.Adopt 75 ℃ of thermostatted waters, continue 8s, diameter is about 20mm, sets up the light Ⅱ° Rat Scald Model.
80 SD rats are divided at random: matched group (inoculated bacteria is not processed), silver sulfadiazine group, green ointment group and each group of multi-effect external preparation.Inoculate respectively Pseudomonas aeruginosa reference culture ATCC27853(1 * 10 at each group rat wound surface after the modeling success
9cfu).After 30min, each group medicine is coated in to respective handling group burned rats position; Not medication of matched group, 1 time/d changes dressings, investigate bacterial content under crust: 24,48 after the wound surface inoculated bacteria, 72h asepsis are got Subeschar tissue, be placed in aseptic glass homogenizer, add the 2mL physiological saline solution, glass homogenizer is connected on motor stirrer, tissue is made to homogenate, the homogenate doubling dilution, get the 0.1mL diluent and carry out count plate, computing formula: every gram tissue bacterial content (cfu/g)=clump count (cfu) * extension rate/tissue weight (g), and the bacterium colony on the plate of making even carries out Gram's staining and biochemical reaction is identified strain.
Experimental result: with matched group, compare, the multi-effect external preparation can significantly suppress the Pseudomonas aeruginosa of burn wound, and effect is better than commercially available anti-infective Sulfadiazine Silver Cream and green ointment.
The results are shown in Table 2:
The impact (n=10) of table 2 multi-effect external preparation on each time point of Subeschar tissue
Annotate:
acompare P<0.05 with matched group;
bcompare P<0.05 with the silver sulfadiazine group;
ccompare P<0.05 with the green ointment group.
3) hemostasis experiment
Experiment material: SD rat 180-220g, by The Fourth Military Medical University's Experimental Animal Center, provided, YUNNAN BAIYAO is fallen apart (YUNNAN BAIYAO group), prepared multi-effect external preparation in embodiment 1-5.
Experimental technique: by 36 body weight 180-220g rat random packet, 6 every group, be respectively positive controls and each group of multi-effect external preparation.Preparation rats'liver middle period excision Hemorrhage Model.Lumbar injection 10% chloral hydrate 1mL anesthetized rat, cut off abdominal muscle along ventrimeson under arcus costarum, the extruding abdominal part is extruded the liver middle period from incision, blot liver and after peritoneal fluid, the sterile gauze after weighing is padded on to liver under the middle period on every side, in the above 2cm of liver middle period lower edge place, excise the liver middle period fast, evenly smear equivalent positive drug and Experimental agents in incision, start timing to stopped bleeding, take and ooze out as the stopped bleeding standard without BRB, observe each group hemostasis process of setting, record bleeding time and amount of bleeding.Bleeding time started to stopped bleeding for the excision liver middle period, and amount of bleeding is sterile gauze weight difference before and after excision.
Experimental result: result is as shown in table 3, and in rats'liver middle period excision Hemorrhage Model, the bleeding time of each group of multi-effect external preparation is compared without significant difference with positive controls with amount of bleeding, and haemostatic effect is identical with positive control drug.（P>0.05）
The haemostatic effect of table 3 multi-effect external preparation
4) promoting healing experiment
Experiment material: 80 of SD rats, body weight 180-220g, male and female half and half, provided by The Fourth Military Medical University's Experimental Animal Center; Silver sulfadiazine ointment (Guangdong Heng Jian pharmaceutical Co. Ltd), Contractubex (German MERZ); Prepared multi-effect external preparation in embodiment 1-5.
Experimental technique: 80 rats are divided into to 8 groups at random, 10 every group, male and female half and half.24h before test, by being cut by hair of rat back both sides, then, with 8% sodium sulfide depilation, area is 3cm * 3cm.Before causing injury, with pentobarbital sodium, anaesthetize sb. generally.Adopt 90 ℃ of thermostatted waters, continue 8s, set up light Ⅱ° rats after burn model.After the modeling success, the not medication of blank group, positive controls is evenly smeared silver sulfadiazine ointment in wound surface, and all the other each groups are evenly smeared respectively the described multi-effect external preparation of embodiment 1-5 in wound surface.Change dressings 1 times/day.Continuous Observation 14 days.Investigation project: 1. gross examination of skeletal muscle: a shallow II ° burn wound take incrustation come off after and grow virgin wool as standard.In case of necessity, the omnidistance vital signs such as anus temperature, breathing and heart rate of measuring of experiment.2. wound healing time: respectively form the contrast of face healing time.3. Wound healing rate:
Wound healing rate=((original wound surface area-the wound surface area does not heal)/original wound surface area) * 100%
Experimental result: 1. gross examination of skeletal muscle: after wound 1-2 days matched groups and Kang Ruibao form swelling of the face swollen, ooze out and redness the most obvious, all the other each groups are lighter; Within 3 days, respectively form face all dry later, form dry crusts, matched group formation dry crusts speed is the slowest, and the Contractubex group is equally very slow, and the silver sulfadiazine group is slightly fast, and each group of multi-effect external preparation is the fastest.2. wound healing time: matched group is 17.2 ± 0.81d, the Contractubex group is 16.4 ± 1.25d, the silver sulfadiazine group is 14.03 ± 0.72d, and each group of multi-effect external preparation is respectively 12.58 ± 0.85d, 13.18 ± 0.75d, 12.28 ± 0.45d, 11.64 ± 0.65d, 12.03 ± 0.72d.The wound healing time of each group of multi-effect external preparation significantly is shorter than matched group, Contractubex combination silver sulfadiazine group.3. Wound healing rate: in Table 4.
Table 4 is respectively formed face healing rate (x ± SD, %, n=6)
Annotate:
acompare P<0.05 with matched group;
bcompare P<0.05 with the Contractubex group;
ccompare P<0.05 with the silver sulfadiazine group.
Above experimental result shows, the prepared multi-effect external preparation of embodiment 1-5 has significant infection, analgesia, hemostasis and agglutinant effect, wherein, the non-marketed drugs green ointment that is inferior to of analgesic effect, have synergism aspect infection and promoting healing: its anti-infectious function is better than marketed drugs green ointment and Sulfadiazine Silver Cream, and the promoting healing effect is better than marketed drugs Kang Ruibao and Sulfadiazine Silver Cream.
The present invention has following features:
1. have hemostasis, analgesia, promoting healing, infection multiple action concurrently, can be used as skin superficial scratch, lacerated wound, wound, burn very first time medicine; 2. Transdermal absorption is good, has reduced medication number of times clinically, has reduced medical expense, has facilitated medication; 3. overcome Chinese medicine compound analgesic complicated component, dose is large, material base is indefinite, analgesic effect is not remarkable, and onset waits shortcoming slowly; 4. the characteristics that have broad-spectrum antiseptic, resistant rate is extremely low, aspect promoting healing and infection, has synergism, stronger than the drug effect of similar drugs.
Claims (10)
1. a multi-effect external preparation that is used for the treatment of the shallow skin injury, it is characterized in that: this external preparation is comprised of the coagulation matters of 1-20%, the analgesic of 0.2-10%, the promoting healing thing of 0.2-20%, the anti-biotic material of 0.005-10% and the pharmaceutic adjuvant of 40-90% by mass fraction.
2. a kind of multi-effect external preparation that is used for the treatment of the shallow skin injury according to claim 1, it is characterized in that: described coagulation matters is one or both in thrombin or Fibrinogen, described analgesic is local anesthetic, described promoting healing thing is one or both in heparin sodium or allantoin, and described anti-biotic material is one or more in nano metal or nano-metal-oxide.
3. a kind of multi-effect external preparation that is used for the treatment of the shallow skin injury according to claim 2, it is characterized in that: described thrombin is through the Polyethylene Glycol covalent modification, and Fibrinogen is through the Polyethylene Glycol covalent modification.
4. a kind of multi-effect external preparation that is used for the treatment of the shallow skin injury according to claim 1, it is characterized in that: described analgesic is one or more in lignocaine, tetracaine, prilocaine, bupivacaine, levobupivacaine, ropivacaine or benzocaine.
5. a kind of multi-effect external preparation that is used for the treatment of the shallow skin injury according to claim 1, it is characterized in that: described anti-biotic material is nanometer silver, nano zine oxide, one or more in nano magnesia or nano calcium oxide, described nanometer silver, nano zine oxide, the particle diameter of nano magnesia or nano calcium oxide is 1-100nm.
6. a kind of multi-effect external preparation that is used for the treatment of the shallow skin injury according to claim 1, it is characterized in that: described preparation is ointment, membrane, powder, Emulsion, solution or gel.
7. a kind of multi-effect external preparation that is used for the treatment of the shallow skin injury according to claim 6, it is characterized in that: the preparation method of described gel is:
1. carbomer is added in ultra-pure water and carry out the nature swelling and obtain transparent colloid, in transparent colloid, add glycerol, colloidal sol then stirs to obtain; 2. analgesic is joined in described colloidal sol, then with triethanolamine, regulate pH to 6-8; 3. through step 2. after, coagulation matters, promoting healing thing and anti-biotic material are joined in described colloidal sol, add again ultra-pure water after being uniformly mixed and obtain mixture, by mixture stir rear degassed, sterilizing, embedding, packing.
8. a kind of multi-effect external preparation that is used for the treatment of the shallow skin injury according to claim 1, it is characterized in that: described external preparation is comprised of the thrombin through the Polyethylene Glycol covalent modification of 2-10%, the Fibrinogen through the Polyethylene Glycol covalent modification of 2-10%, local anesthetic, 0.013-0.067% heparin sodium, the allantoin of 0.5-2%, the nano metal of 0.01-2% or the pharmaceutic adjuvant of nano-metal-oxide and 70-90% of 0.2-2% by mass fraction.
9. a kind of multi-effect external preparation that is used for the treatment of the shallow skin injury according to claim 8, it is characterized in that: described local anesthetic is lignocaine, tetracaine, prilocaine or benzocaine, described nano metal is nanometer silver, and described nano-metal-oxide is nano zine oxide, nano magnesia or nano calcium oxide.
10. a multi-effect external preparation that is used for the treatment of as claimed in claim 1 the shallow skin injury is treated the purposes in shallow skin injury medicine in preparation.
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| CN108272646A (en) * | 2018-04-11 | 2018-07-13 | 佳木斯大学 | A kind of antibacterial toothpaste and preparation method thereof of hydroxyl apatite |
| CN108744028A (en) * | 2018-08-01 | 2018-11-06 | 温州医科大学 | Antimicrobial antiphlogistic porous metals holder and its preparation method and application |
| CN109010906A (en) * | 2018-08-16 | 2018-12-18 | 陈明远 | A kind of biological glue and its working method for promoting postoperative wound local hemostasis and promoting postoperative wound epithelialization |
| CN111035791A (en) * | 2020-01-13 | 2020-04-21 | 曹传波 | Medical dressing and preparation method thereof |
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| CN1335757A (en) * | 1998-11-12 | 2002-02-13 | 聚合体生物科学公司 | Hemostatic polymer useful for rapid blood coagulation and hemostasis |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272646A (en) * | 2018-04-11 | 2018-07-13 | 佳木斯大学 | A kind of antibacterial toothpaste and preparation method thereof of hydroxyl apatite |
| CN108744028A (en) * | 2018-08-01 | 2018-11-06 | 温州医科大学 | Antimicrobial antiphlogistic porous metals holder and its preparation method and application |
| CN109010906A (en) * | 2018-08-16 | 2018-12-18 | 陈明远 | A kind of biological glue and its working method for promoting postoperative wound local hemostasis and promoting postoperative wound epithelialization |
| CN109010906B (en) * | 2018-08-16 | 2021-05-14 | 陈明远 | Biological glue for promoting postoperative wound local hemostasis and promoting postoperative wound epithelization and working method thereof |
| CN111035791A (en) * | 2020-01-13 | 2020-04-21 | 曹传波 | Medical dressing and preparation method thereof |
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| CN103495174B (en) | 2015-10-07 |
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