CN103432587B - Environmental-friendly film coating premix and preparation method thereof - Google Patents
Environmental-friendly film coating premix and preparation method thereof Download PDFInfo
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- CN103432587B CN103432587B CN201310380776.6A CN201310380776A CN103432587B CN 103432587 B CN103432587 B CN 103432587B CN 201310380776 A CN201310380776 A CN 201310380776A CN 103432587 B CN103432587 B CN 103432587B
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Abstract
The invention belongs to the technical field of pharmaceutical production and relates to an environmental-friendly film coating premix and a preparation method thereof. According to the environmental-friendly film coating premix and the preparation method thereof disclosed by the invention, different film-forming agents are compounded to improve the film-forming property and moisture resistance of a single film-forming agent, and meanwhile, existing artificial synthetic pigments are replaced by natural pigments, so that the environmental-friendly film coating premix is stable in color, has certain nutritive value and is good in liquidity and dispersibility; products of a part of model numbers are particularly suitable for coating healthcare food tablets.
Description
Technical field
The invention belongs to pharmaceutical production technical field, relate to a kind of environment-friendly type film coating pre-mix dose and preparation method thereof.The present invention is composite by film former of the same race not, film property and the moisture resistance of single film former have been improved, adopt natural pigment to replace existing synthetic food color simultaneously, its colour stable and there is certain nutritive value, mobility, good dispersion, the product of part model is particularly suitable for the coating of health caring food tablet.Test and also prove after the polyvidone that adds appropriate specific standard in this product, color and luster is more stable and bright-coloured, is a kind of environment-friendly type film coating pre-mix dose.
Background technology
Medicine coating is one of most crucial Technology of modern pharmaceutical, and film coating is current most widely used Technology, by spray coated technique, polymer solution or dispersion liquid are uniformly coated on to the surface of solid preparation, be formed with the plastic thin rete of certain thickness and intensity, have that good stability, coating time are short, weightening finish less and the advantage such as moisture resistance is good, become the main coating means of solid preparation.Stomach dissolution type coating material refers to that clothing film can dissolve in gastric juice or the thin film coating material of disintegrate release, and hydroxypropyl methylcellulose is conventional stomach dissolution type coating material film former.
Prior art weak point is:
1. the film coating formula of hypromellose series, moist after film forming, bright-colored stable, have very high hot strength, but coating overlong time is larger to the quality influence of some thermal sensitivity medicines.
2. there is the easy moisture absorption in the film coating product of solid preparation, covering power is undesirable, in product stock and transportation, often there is problem of appearance, and then affect the inherent quality of product, at present, the general aluminium of coloring agent color lake in the formula of thin film coating material, but long-term a large amount of use, especially for health food, long-term excessive use artificial color can bring healthy hidden danger.
Summary of the invention
In order to solve problems of the prior art, the present invention is directed to above problem, theoretical based on composite membrane-forming principle and natural pigment microencapsulation, lot of experiments passes through in my company, independent research environment-friendly type film coating pre-mix dose, the powder that employing starch sodium octenyl succinate, konjak starch and hydroxypropyl methylcellulose spraying are dried out, as film former, has effectively improved film properties, is difficult for the moisture absorption; Adopt natural pigment as coloring agent simultaneously, by the microencapsulation to natural pigment, process, improve its stability, there is good mobility and dispersibility, for coating materials, can reach and mix quick, the uniform effect of color and luster, more health environment-friendly.
In order to realize object of the present invention, the technical scheme of employing is summarized as follows:
An environment-friendly type film coating pre-mix dose, is characterized in that, the powder, natural pigment microcapsule and the additives that mainly by starch sodium octenyl succinate, konjak starch and hydroxypropyl methylcellulose spraying, are dried out form.
Described a kind of environment-friendly type film coating pre-mix dose, is characterized in that, preparation technology is: 1. by starch sodium octenyl succinate, konjak starch and hydroxypropyl methylcellulose with spray-dried forms mix homogeneously, obtain mixed-powder; 2. mixed-powder and natural pigment microcapsule and additives are uniformly mixed.
Described natural pigment microcapsule, its preparation technology is: 1. fat-soluble natural pigment is dissolved in certain density ethyl acetate solution, adds wherein the cross-linking sodium carboxymethyl cellulose of certain mass, fully standby as core after swelling; 2. core is slowly joined in ethyl cellulose alcoholic solution, by high pressure homogenize, be prepared into uniform emulsion liquid; 3. even emulsion liquid is slowly added in the water of certain volume, fully disperse, by the dry powder body after natural pigment microencapsulation that makes of spraying.
Described natural pigment microcapsule, is characterized in that, the mean diameter of microcapsule is below 10 microns.
Described natural pigment microcapsule, is characterized in that, insoluble or be insoluble in water, includes but not limited to natural tomato red pigment and natural chlorophyll.
Described additives, comprise fluidizer and plasticizer.
Compared with prior art, the good effect that the present invention has is:
(1) the mixed-powder that starch sodium octenyl succinate, konjak starch and hydroxypropyl methylcellulose spraying are dried out, as film former, has effectively improved film properties, has reduced the coating time;
(2) adopt natural pigment as coloring agent, by the microencapsulation to natural pigment, process, improve its stability, there is good mobility and dispersibility, for coating materials, can reach and mix quick, the uniform effect of color and luster, more health environment-friendly.
The specific embodiment
Demonstration example 1---environment-friendly type film coating pre-mix dose formula and application
(1) write out a prescription
Starch sodium octenyl succinate: 10%
Konjak starch: 50%
Hydroxypropyl methylcellulose: 36%
Fluidizer: micropowder silica gel 2%
Natural tomato red pigment: 2%
(2) preparation technology
1. by the abundant dispersing and dissolving in water of the starch sodium octenyl succinate of recipe quantity, konjak starch and hydroxypropyl emthylcellulose, mix homogeneously under stirring, dryly obtains mixed-powder by spraying, standby; 2. by recipe quantity natural tomato red pigment microcapsule, join 1., mix homogeneously, then add fluidizer, mix homogeneously, obtains.
This formula is applied to the film coating of medicine, coating quality and having good stability.
Demonstration example 2---the preparation of natural tomato red pigment microcapsule
(1) fill a prescription
Natural tomato red pigment 1.5g
Ethyl cellulose 10g
Cross-linking sodium carboxymethyl cellulose 4.5g
Ethyl acetate 60ml
Water 200ml
(2) preparation technology
Lycopene ethyl acetate saturated solution (the 10% ethyl acetate aqueous solution) 50ml of configuration 30mg/ml, adds 4.5g cross-linking sodium carboxymethyl cellulose, in 40 ℃, stirs 1h; Then according to the ratio of 1:2 (W/W), join in ethyl cellulose solution, after high pressure homogenize, be slowly added to the water, make solid content in 10% left and right, spraying is dry.Spray-dired condition is: 65 ℃ of feeding temperatures, 150 ℃ of intake air temperatures, air outlet temperature 60 C, feed rate 10ml/min.
Demonstration example 3---the preparation of natural chlorophyll microcapsule
(1) fill a prescription
Natural chlorophyll 1g
Ethyl cellulose 8g
Cross-linking sodium carboxymethyl cellulose 6g
Ethyl acetate 50ml
Water 200ml
(2) preparation technology
Chlorophyll ethyl acetate saturated solution (the 10% ethyl acetate aqueous solution) 50ml of configuration 20mg/ml, adds 6g cross-linking sodium carboxymethyl cellulose, in 40 ℃, stirs 1h; Then according to the ratio of 1:1 (W/W), join in ethyl cellulose solution, after high pressure homogenize, be slowly added to the water, make solid content in 10% left and right, spraying is dry.Spray-dired condition is: 70 ℃ of feeding temperatures, 140 ℃ of intake air temperatures, air outlet temperature 70 C, feed rate 15ml/min.
Exemplary scenario described here is only the explanation to the principle of the invention, and preferred embodiment of the present invention, should by any way, not utilize narration above to limit the scope of the invention.The professional person of this area, can utilize principle of the present invention, designs various embodiment, and does not exceed scope of the present invention.
Claims (6)
1. an environment-friendly type film coating pre-mix dose, is characterized in that, the powder, natural pigment microcapsule and the additives that mainly by starch sodium octenyl succinate, konjak starch and hydroxypropyl methylcellulose spraying, are dried out form.
2. a kind of environment-friendly type film coating pre-mix dose as claimed in claim 1, is characterized in that, preparation technology is: 1. by starch sodium octenyl succinate, konjak starch and hydroxypropyl methylcellulose with spray-dried forms mix homogeneously, obtain mixed-powder; 2. mixed-powder and natural pigment microcapsule and additives are uniformly mixed.
3. a kind of environment-friendly type film coating pre-mix dose as claimed in claim 1, it is characterized in that, described natural pigment microcapsule, its preparation technology is: 1. fat-soluble natural pigment is dissolved in certain density ethyl acetate solution, the cross-linking sodium carboxymethyl cellulose that adds wherein certain mass, fully standby as core after swelling; 2. core is slowly joined in ethyl cellulose alcoholic solution, by high pressure homogenize, be prepared into uniform emulsion liquid; 3. even emulsion liquid is slowly added in the water of certain volume, fully disperse, by the dry powder body after natural pigment microencapsulation that makes of spraying.
4. a kind of environment-friendly type film coating pre-mix dose as claimed in claim 1, is characterized in that, the mean diameter of described natural pigment microcapsule is below 10 microns.
5. a kind of environment-friendly type film coating pre-mix dose as claimed in claim 3, is characterized in that, described fat-soluble natural pigment is insoluble or be insoluble in water, is specially: a kind of or two kinds of mixture of natural tomato red pigment and natural chlorophyll.
6. a kind of environment-friendly type film coating pre-mix dose as claimed in claim 1, is characterized in that described additives comprise fluidizer and plasticizer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310380776.6A CN103432587B (en) | 2013-08-28 | 2013-08-28 | Environmental-friendly film coating premix and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310380776.6A CN103432587B (en) | 2013-08-28 | 2013-08-28 | Environmental-friendly film coating premix and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103432587A CN103432587A (en) | 2013-12-11 |
| CN103432587B true CN103432587B (en) | 2014-10-29 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3982939A1 (en) * | 2019-06-14 | 2022-04-20 | Folium Biosciences Europe B.V. | Method for micro-encapsulation of natural ingredients by means of contacting with supercritical gas |
| CN114957807A (en) * | 2022-01-24 | 2022-08-30 | 昆明理工大学 | Sodium starch octenyl succinate preservative film and preparation method thereof |
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| CA2770212C (en) * | 2009-08-28 | 2017-03-28 | Hercules Incorporated | Film coating composition from solid powder compounds |
| CN102579391A (en) * | 2012-03-05 | 2012-07-18 | 北京皇岛海洋生物科技有限公司 | Gastric soluble compound seaweed polysaccharide film coating premix and liquid preparation method adopting same |
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